119,475 results match your criteria Implanted Medical Devices


Left Atrial Appendage Closure Device Implantation in Patients with Prior Intracranial Hemorrhage.

Heart Rhythm 2018 Nov 19. Epub 2018 Nov 19.

Section of Cardiac Pacing and Electrophysiology, Heart and Vascular Institute, Cleveland Clinic Foundation, Cleveland, OH. Electronic address:

Background: The Watchman™ device (Boston Scientific, MN), used for left atrial appendage closure (LAAC) was approved for stroke prevention in patients with atrial fibrillation (AF) and an appropriate rationale to avoid long-term oral anticoagulation. Patients with AF and prior intracranial hemorrhage (ICH) were excluded from clinical trials due to perceived risks of peri-operative anticoagulation.

Objective: We studied the efficacy and safety of LAAC using Watchman™ in patients with AF and prior ICH. Read More

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November 2018

Carbon disulfide induces embryo loss by perturbing the expression of the mTOR signalling pathway in uterine tissue in mice.

Chem Biol Interact 2018 Dec 3. Epub 2018 Dec 3.

Department of Occupational and Environmental Health, School of Public Health, Shandong University, China. Electronic address:

Understanding of the mechanism of embryo loss is critical for successful pregnancy considering an increase in the incidence of infertility. In this study, we focus on the effect of alterations in the expression of the AKT/AMPK/mTOR signalling pathway in mouse uterine tissue after embryo loss induced by harmful environmental exposure to carbon disulfide (CS). CS is a material used in certain production processes, and women are sometimes exposed to it in occupational settings. Read More

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December 2018

[Interlocking femoral nail and total knee Arthroplasty in one stage for a patient with a femoral diaphyseal stress fracture].

Acta Ortop Mex 2018 May-Jun;32(3):163-166

Servicio de Cirugía Ortopédica y Traumatología, Hospital de Sabadell. Institut Universitari Parc Taulí Universitat Autònoma de Barcelona, España.

We present the case of an 81-year-old woman who was followed up by the Rheumatology Service for osteoporosis and treated with bisphosphonates for more than five years. She reported a fracture of the distal third of the contralateral femur by a low energy mechanism, treated with retrograde intramedullary nailing the previous year. She presented a clinic of cruralgia and left gonalgia, without previous trauma. Read More

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December 2018

Micro-ATR FTIR, SEM-EDS and X-ray micro-CT: an innovative multi-technique approach to investigate bone affected by peri-implantitis.

Int J Oral Maxillofac Implants 2018 Dec 5. Epub 2018 Dec 5.

Purpose: The aim of this work was to prove the synergic complementarity of attenuated total reflection Fourier transform infrared microspectroscopy (micro-ATR FTIR), scanning electron microscopy (SEM) coupled with energy-dispersive x-ray spectroscopy (EDS) and x-ray computed microtomography (micro-CT) by studying implant samples with bone affected by peri-implantitis.

Materials And Methods: Six samples of implanted bone affected by peri-implantitis and one control healthy bone were analyzed. Thick bone sections included in epoxy-resin and removed implants were analyzed by micro-ATR FTIR, SEM-EDS, and micro-CT. Read More

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December 2018

Regenerated Bone Pattern Around Exposed Implants with Various Designs.

Int J Oral Maxillofac Implants 2018 Dec 5. Epub 2018 Dec 5.

Purpose: The design and surface features of dental implants substantially affect the healing and remodeling of adjacent bones. This study aimed to investigate the impact of design and surface on bone regeneration using implants of two different pitches, each with three different surface features.

Materials And Methods: Custom-manufactured titanium implants (length, 10 mm; diameter, 3. Read More

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December 2018
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Knitted silk mesh-like scaffold incorporated with sponge-like regenerated silk fibroin/collagen I and seeded with mesenchymal stem cells for repairing Achilles tendon in rabbits.

Acta Bioeng Biomech 2018 ;20(4):77-87

Institute of Bioengineering, Zhejiang Academy of Medical Sciences, Hangzhou, Zhejiang Province, China.

A scaffold knit with natural sericin-free silk fibroin fiber possesses desirable mechanical properties, biocompatibility, ease of fabrication, and slow degradability. However, regenerated silk fibroin degrades faster than natural silk. In this study, natural silk fibroin fiber mesh-like scaffolds were prepared by a weft-knitting method and the pores were filled with sponge-like regenerated silk fibroin-collagen I. Read More

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January 2018
1 Read

Evaluation of the safety of users of active implantable medical devices (AIMD) in the working environment in terms of exposure to electromagnetic fields - practical approach to the requirements of European Directive 2013/35/EU.

Int J Occup Med Environ Health 2018 Nov 5. Epub 2018 Nov 5.

Central Institute for Labour Protection - National Research Institute, Warszawa, Poland (Laboratory of Electromagnetic Hazards).

Objectives: Electromagnetic fields (EMF) may cause malfunctions in electronic devices, in particular in active implantable medical devices (AIMD), along with discomfort or health hazards to users. The use of AIMD by workers is increasing (especially cardiac pacemakers, implantable cardioverter defibrillators and wearable insulin infusion pumps). Electromagnetic fields may be much stronger in the working environment than applied in basic immunity tests of AIMD (based on EN 60601- 1-2:2015 and EN 50527-1:2016). Read More

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November 2018
1 Read

Feasibility of closed-MLC tracking using high sensitivity and multi-layer electronic portal imagers.

Phys Med Biol 2018 Dec 6;63(23):235030. Epub 2018 Dec 6.

Department of Radiation Oncology, Division of Medical Physics and Biophysics, Brigham and Women's Hospital, Dana-Farber Cancer Institute, and Harvard Medical School, Boston, MA 02115, United States of America. Author to whom any correspondence should be addressed.

In radiation therapy, improvements in treatment conformality are often limited by movement of target tissue. To better treat the target, tumor tracking strategies involving beam's-eye-view (BEV) have been explored. However, localization surrogates like implanted fiducial markers may sometimes leave the field-of-view (FOV), as defined by the linear accelerator (LINAC) multi-leaf collimator (MLC). Read More

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December 2018
2 Reads

Comparison of Effects of Light Anesthetics, Diethyl Ether and Carbon Dioxide, on Hypothalamic Paraventricular Nucleus D and D Dopamine Receptors- and Glucosensitive Neurons-Induced Food Intake in Fasted Conscious Rats.

Basic Clin Neurosci 2018 Jul-Aug;9(4):269-274. Epub 2018 Jul 1.

Neurophysiology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Introduction: Carbon Dioxide (CO) and diethyl ether are used as light anesthetics. However, experimental data about their side effects are scarce. In addition, in all our previous works on regulatory mechanisms of hypothalamus during food intake, including the effect of Paraventricular Nucleus (PVN) D and D dopamine receptors and glucosensitive neurons, the drug injections were performed under brief diethyl ether anesthesia. Read More

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Performance of gimbal-based dynamic tumor tracking for treating liver carcinoma.

Radiat Oncol 2018 Dec 5;13(1):242. Epub 2018 Dec 5.

Department of Radiation Oncology, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Universitätsstraße 27, 91054, Erlangen, Germany.

Background: Since the introduction of tumor tracking in radiotherapy, it is possible to ensure a precise irradiation of moving targets. To follow the tumor movement, most systems rely on the detection of implanted markers and correlation models between the internal and external patient movement. This study reports the clinical workflow and first results of the dynamic tumor tracking (DTT) performance for patients with liver carcinoma at the Vero SBRT system of the University Hospital Erlangen regarding the detection of the internal marker and the changes of the determined correlation models. Read More

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December 2018

Evaluation of Continuous Lactate Monitoring Systems within a Heparinized In Vivo Porcine Model Intravenously and Subcutaneously.

Biosensors (Basel) 2018 Dec 4;8(4). Epub 2018 Dec 4.

Biocrede Inc., Plymouth, MI 48170, USA.

We present an animal model used to evaluate the in vivo performance of electrochemical amperometric continuous lactate sensors compared to blood gas instruments. Electrochemical lactate sensors were fabricated, placed into 5 Fr central venous catheters (CVCs), and paired with wireless potentiostat devices. Following in vivo evaluation and calibration, sensors were placed within the jugular and femoral veins of a porcine subject as a preliminary assessment of in vivo measurement accuracy. Read More

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December 2018

Outcomes of Repeat Left Ventricular Assist Device Exchange.

ASAIO J 2018 Nov 28. Epub 2018 Nov 28.

From the Division of Cardiothoracic Transplant and Assist Devices, Baylor College of Medicine.

Implantable continuous-flow left ventricular assist devices (CF-LVADs) are used for long-term LV support in bridging patients to heart transplantation or as destination therapy. With prolonged support times, some patients will have repeat complications necessitating multiple device exchanges. To elucidate the safety and efficacy of repeat device exchange, we retrospectively reviewed data from 25 patients who underwent two or more CF-LVAD implantations between July 2005 and August 2017. Read More

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November 2018

Evaluation of Space-Maintaining Sinus Membrane Using the Absorbable Screws in Sinus Lifting Bone Augmentation.

Implant Dent 2018 Nov 30. Epub 2018 Nov 30.

Professor, Division of Clinical Medicine, Department of Oral and Maxillofacial Surgery, Graduate Faculty of Interdisciplinary, University of Yamanashi, Yamanashi, Japan.

Purpose: We investigated whether it was possible to perform a sinus lift maintaining absorbable screw material with biological activity.

Materials And Methods: Thirty rabbits were used. The screws used in this study were unsintered hydroxyapatite/poly-L-lactic acid (uHA/PLLA) (uHA/PLLA group) and titanium alloy (Ti group). Read More

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November 2018

Integrating 3D Printing and Biomimetic Mineralization for Personalized Enhanced Osteogenesis, Angiogenesis, and Osteointegration.

ACS Appl Mater Interfaces 2018 Dec 3. Epub 2018 Dec 3.

Department of Chemistry and Biochemistry, Stephenson Life Sciences Research Center, Institute for Biomedical Engineering, Science and Technology , University of Oklahoma , Norman , Oklahoma 73072 , United States.

Titanium (Ti) alloy implants can repair bone defects at load-bearing sites. However, they mechanically mismatch with the natural bone and lack customized adaption with the irregularly major-sized load-bearing bone defects, resulting in the failure of implant fixation. Mineralized collagen (MC), a building block in bone, can induce angiogenesis and osteogenesis, and 3D printing technology can be employed to prepare scaffolds with an overall shape customized to the bone defect. Read More

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December 2018

Effect of Early Sacral Neuromodulation on Bladder Function in a Rat Model of Incomplete Spinal Cord Injury Due to Focal Contusion.

Neuromodulation 2018 Dec 2. Epub 2018 Dec 2.

Department of Urology, Seoul National University Bundang Hospital, Seongnam, South Korea.

Objectives: Incomplete spinal cord injury (SCI) accounts for two-thirds of all SCIs in clinical practice. Preclinical research on the effect of sacral neuromodulation (SNM) on bladder function, however, has been focused only on animal models of complete SCI. We aimed to evaluate the effect of early SNM on bladder responses in a rat model of incomplete SCI. Read More

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December 2018

One-year follow-up study of iBTA-induced allogenic biosheet for repair of abdominal wall defects in a beagle model: a pilot study.

Hernia 2018 Nov 30. Epub 2018 Nov 30.

Biotube Co., Ltd, 2-13-11 Shinkawa, Chuo, Tokyo, 104-0033, Japan.

Purpose: We evaluated the usefulness of biosheet, an in-body tissue-engineered collagenous membrane, as a novel repair material for abdominal wall defects in a beagle model.

Methods: Biosheets were prepared by embedding molds into subcutaneous pouches in two beagle dogs for 2 months, with subsequent storage in 70% ethanol. The obtained biosheets (thickness 0. Read More

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November 2018

Plasma processing of PDMS based spinal implants for covalent protein immobilization, cell attachment and spreading.

J Mater Sci Mater Med 2018 Nov 30;29(12):178. Epub 2018 Nov 30.

School of Physics, University of Sydney, Sydney, NSW, 2006, Australia.

PDMS is widely used for prosthetic device manufacture. Conventional ion implantation is not a suitable treatment to enhance the biocompatibility of poly dimethyl siloxane (PDMS) due to its propensity to generate a brittle silicon oxide surface layer which cracks and delaminates. To overcome this limitation, we have developed new plasma based processes to balance the etching of carbon with implantation of carbon from the plasma source. Read More

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November 2018

Study of Percutaneous Stent Placement with Iodine-125 Seed Strand for Malignant Biliary Obstruction.

Cardiovasc Intervent Radiol 2018 Nov 30. Epub 2018 Nov 30.

Department of Interventional Radiology, The First Affiliated Hospital of Nanjing Medical University, 300 Guangzhou Road, Gulou District, Nanjing, 210029, China.

Purpose: To evaluate the effectiveness and safety of simultaneous placement of a self-expandable metallic stents (SEMS) and iodine-125 seed strand in the management of malignant obstructive jaundice (MOJ).

Materials And Methods: This study included 132 patients with MOJ treated from November 2015 to October 2017. Forty-five patients underwent insertion of SEMS with iodine-125 seed strands (Seeds group); the remaining 87 patients underwent SEMS placement alone (Control group). Read More

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November 2018

Glial responses to implanted electrodes in the brain.

Nat Biomed Eng 2017 Nov 10;1(11):862-877. Epub 2017 Nov 10.

Department of Biomedical Engineering, Michigan State University, East Lansing, MI, USA.

The use of implants that can electrically stimulate or record electrophysiological or neurochemical activity in nervous tissue is rapidly expanding. Despite remarkable results in clinical studies and increasing market approvals, the mechanisms underlying the therapeutic effects of neuroprosthetic and neuromodulation devices, as well as their side effects and reasons for their failure, remain poorly understood. A major assumption has been that the signal-generating neurons are the only important target cells of neural-interface technologies. Read More

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November 2017

Results and limits of posterior cranial vault expansion by osteotomy and internal distractors.

Surg Neurol Int 2018 30;9:217. Epub 2018 Oct 30.

Craniofacial Unit, Department of Pediatric Neurosurgery, Hôpital Necker-Enfants Malades, Paris, France.

Background: Expanding the posterior cranial vault has become a common procedure in the treatment of complex craniosynostosis. Several techniques are available to remodel the posterior vault. Aim of this study was to analyze the posterior vault distraction osteogenesis. Read More

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October 2018

Remote Monitoring of Atrial High Rate Episodes in Pacemaker Patients. The Rapid Study Design.

J Atr Fibrillation 2018 Aug 31;11(2):2075. Epub 2018 Aug 31.

Departmental Unit of Electrophysiology, Evaluation and Treatment of Arrhythmias, Monaldi Hospital, Naples, Italy.

Background: Remote Monitoring (RM) has been introduced for several years and nowadays most pacemakers are equipped with such a technology. RM can provide early detection of high atrial rate episodes (AHREs) onset and enable prompt medical intervention. However, there are still little data on the clinical reactions triggered by the AHRE detected by RM of pacemaker recipients and on their possible benefit on patients' outcome. Read More

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Long-term results after open repair of inflammatory infrarenal aortic aneurysms.

J Vasc Surg 2018 Jun 28. Epub 2018 Jun 28.

Department of Vascular and Endovascular Surgery, University Hospital Heidelberg, Heidelberg, Germany.

Objective: The objective of this study was to investigate the long-term outcome after open repair of inflammatory infrarenal aortic aneurysms.

Methods: A total of 62 patients (mean age, 68.9 ± 8. Read More

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June 2018
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A phase IIb, randomised, double-blind, placebo-controlled, dose-ranging investigation of the safety and efficacy of NTCELL [immunoprotected (alginate-encapsulated) porcine choroid plexus cells for xenotransplantation] in patients with Parkinson's disease.

Parkinsonism Relat Disord 2018 Nov 13. Epub 2018 Nov 13.

Department of Neurology, Auckland City Hospital, 2 Park Road, Grafton, Auckland, 1023, New Zealand; Centre for Brain Research, University of Auckland, New Zealand. Electronic address:

Introduction: Regenerative therapies in Parkinson's disease aim to slow neurodegeneration and re-establish damaged neuronal circuitry. Neurotrophins are potent endogenous regulators of neuronal survival, development and regeneration. They represent an attractive regenerative treatment option in Parkinson's disease. Read More

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November 2018

Direct Electrical Stimulation of Lateral Orbitofrontal Cortex Acutely Improves Mood in Individuals with Symptoms of Depression.

Curr Biol 2018 Nov 21. Epub 2018 Nov 21.

Weill Institute for Neurosciences, University of California, San Francisco, 675 Nelson Rising Ln, San Francisco, CA 94158, USA; Department of Neurological Surgery, University of California, San Francisco, 400 Parnassus Ave, San Francisco, CA 94143, USA. Electronic address:

Mood disorders cause significant morbidity and mortality, and existing therapies fail 20%-30% of patients. Deep brain stimulation (DBS) is an emerging treatment for refractory mood disorders, but its success depends critically on target selection. DBS focused on known targets within mood-related frontostriatal and limbic circuits has been variably efficacious. Read More

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November 2018
3 Reads

A mating plug in a squid? Sneaker spermatophores can block the female sperm-storage organ in Doryteuthis plei.

Zoology (Jena) 2018 Oct 8;130:47-56. Epub 2018 Sep 8.

Department of Zoology, Institute of Biosciences, University of São Paulo, Rua do Matão, Travessa 14, n. 101, 05508-090, São Paulo, SP, Brazil. Electronic address:

Males from numerous animal taxa have evolved strategies for obstructing the female genitalia with copulatory plugs, reducing the risk of sperm competition and thus resulting in an advantage in sexual selection. Several lines of evidence suggest that sperm competition is a common feature in the complex squid mating systems, which include the evolution of alternative mating tactics (consort vs. sneaker). Read More

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October 2018

Evaluation of a dual signal subspace projection algorithm in magnetoencephalographic recordings from patients with intractable epilepsy and vagus nerve stimulators.

Neuroimage 2018 Nov 28. Epub 2018 Nov 28.

Department of Radiology and Biomedical Imaging, University of California, San Francisco, CA, 94143-0628, USA; Department of Neurology, University of California, San Francisco, CA 94143-0628, USA. Electronic address:

Magnetoencephalography (MEG) data is subject to many sources of environmental noise, and interference rejection is a necessary step in the processing of MEG data. Large amplitude interference caused by sources near the brain have been both common in clinical settings and difficult to reject. Artifacts from vagal nerve stimulators (VNS) are a common and difficult example. Read More

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November 2018
1 Read

Cannabinoid receptor type-1 partially mediates metabolic endotoxemia-induced inflammation and insulin resistance.

Physiol Behav 2018 Nov 29;199:282-291. Epub 2018 Nov 29.

Department of Foods and Nutrition, University of Georgia, Athens, GA 30602, USA. Electronic address:

Circulating levels of bacterial lipopolysaccharide (LPS) or endotoxin are chronically elevated in obesity (metabolic endotoxemia), resulting in low-grade inflammation. Metabolic endotoxemia has been identified as a triggering factor for obesity-associated metabolic complications such as insulin resistance. Furthermore, LPS has been shown to modulate endocannabinoid synthesis and notably to induce cannabinoid receptor type-1 (CB1) ligand synthesis. Read More

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November 2018

Influence of Elevated Intra-abdominal Pressure on Suture Tension Dynamics in a Porcine Model.

J Surg Res 2019 Jan 31;233:207-212. Epub 2018 Aug 31.

Department of Surgery, Rhenish-Westphalian Technical University of Aachen, Aachen, Germany. Electronic address:

Background: Inadequate suture tension is a risk factor for the failure of laparotomy closure. Suture tension dynamics in the abdominal wall are still obscure due to the lack of measuring devices. To answer the questions if intra-abdominal hypertension (IAH) influences suture tension in midline laparotomies and if IAH leads to a permanent loss of suture tension, microsensors were applied in a porcine model of IAH. Read More

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January 2019

Dissected Aorta Repair Through Stent Implantation trial: Canadian results.

J Thorac Cardiovasc Surg 2018 Oct 26. Epub 2018 Oct 26.

Division of Cardiac Surgery, University of Alberta, Edmonton, Alberta, Canada. Electronic address:

Objectives: We describe the Canadian results of the Ascyrus Medical Dissection Stent (AMDS), a novel partially uncovered aortic arch hybrid graft implanted antegrade during hypothermic circulatory arrest to promote true lumen expansion and enhance aortic remodeling.

Methods: From March 2017 to February 2018, 16 consecutive patients (66 ± 12 years; 38% female) presented with acute type A aortic dissections and underwent emergent surgical aortic repair with AMDS implantation. All patients presented with DeBakey I aortic dissection, with evidence of malperfusion in 50% (n = 8) of patients. Read More

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October 2018

Vertical bone regeneration with synthetic biomimetic calcium phosphate onto the calvaria of rats.

Tissue Eng Part C Methods 2018 Dec 1. Epub 2018 Dec 1.

University of Nantes , Faculty of Medicine , Inserm UMR 957 - Lab. pathophsyiology of bone resorption , 1 rue Gaston Veil , Nantes, France , 44035 ;

Bone regeneration is often required to provide adequate oral rehabilitation before dental implants. Vertical ridge augmentation is the most challenging of all situations and often requires the use of autologous bone grafting. However, autologous bone grafting induces morbidity and the harvestable bone is limited in quantity. Read More

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December 2018

Implantation of defined activities of phosphorus 32 with reduced target damage.

Rev Sci Instrum 2018 Nov;89(11):113304

Central Unit for Ionbeams and Radionuclides (RUBION), Ruhr-University Bochum, Universitätsstraße 150, D-44801 Bochum, Germany.

Materials doped with the unstable isotope phosphorus 32 are promising candidates for use in brachytherapeutic applications. One way to dope a material with P is by ion implantation. However, the bombardment of the target with ions other than P due to impurities of the ion beam leads to unnecessary damages of the target, which might reduce its potential for medical applications. Read More

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November 2018

Nanoindentation and TEM to Study the Cavity Fate after Post-Irradiation Annealing of He Implanted EUROFER97 and EU-ODS EUROFER.

Micromachines (Basel) 2018 Nov 29;9(12). Epub 2018 Nov 29.

Centro Nacional de Microscopía Electrónica, Universidad Complutense de Madrid, 28040 Madrid, Spain.

The effect of post-helium irradiation annealing on bubbles and nanoindentation hardness of two reduced activation ferritic martensitic steels for nuclear fusion applications (EUROFER97 and EU-ODS EUROFER) has been studied. Helium-irradiated EUROFER97 and EU-ODS EUROFER were annealed at 450 °C for 100 h in an argon atmosphere. The samples were tested by nanoindentation and studied by transmission electron microscopy extracting some focused ion beam lamellae containing the whole implanted zone (≈50 µm). Read More

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November 2018

Transcatheter Closure of Perimembranous Ventricular Septal Defects in Children using a Wire-Drifting Technique.

Clinics (Sao Paulo) 2018 Nov 29;73:e371. Epub 2018 Nov 29.

Department of Structural Heart Disease, The First Affiliated Hospital of Xi'an Jiaotong University, Shaanxi Province, China.

Objective: Explore the feasibility and safety of transcatheter closure of perimembranous ventricular septal defects using a wire-drifting technique (WT) in children.

Methods: We retrospectively analyzed 121 pediatric patients diagnosed with perimembranous ventricular septal defects who underwent interventional treatment at the First Affiliated Hospital of Xi'an Jiaotong University from Dec 2011 to Dec 2014. Based on the method used for arteriovenous loop establishment during the procedure, the patients were divided into a conventional technique (CT) group and a WT group. Read More

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November 2018

Updated Meta-analysis on the Closure of Patent Foramen Ovale in Reduction of Stroke Rates: the DEFENSE-PFO Trial Does not Change the Scenario.

Braz J Cardiovasc Surg 2018 Sep-Oct;33(5):511-521

Department of Cardiovascular Surgery of the Pronto Socorro Cardiológico de Pernambuco (PROCAPE), Recife, PE, Brazil.

Objective: We aimed to analyze whether patent foramen ovale (PFO) closure reduces the risk of stroke, assessing also some safety outcomes after the publication of a new trial.

Introduction: The clinical benefit of closing a PFO has been an open question, so it is necessary to review the current state of published medical data in regards to this subject.

Methods: MEDLINE, EMBASE, CENTRAL/CCTR, SciELO, LILACS, Google Scholar and reference lists of relevant articles were used to search for randomized controlled trials (RCTs) that reported any of the following outcomes: stroke, death, major bleeding or atrial fibrillation. Read More

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June 2018
3 Reads

Direct CNS delivery of proteins using thermosensitive liposome-in-gel carrier by heterotopic mucosal engrafting.

PLoS One 2018 5;13(12):e0208122. Epub 2018 Dec 5.

Department of Pharmaceutical Sciences, School of Pharmacy, Northeastern University, Boston, MA, United States of America.

Delivering therapeutics across the blood-brain barrier (BBB) for treating central nervous system (CNS) diseases is one of the biggest challenges today as the BBB limits the uptake of molecules greater than 500 Da into the CNS. Here we describe a novel trans-nasal mucosal drug delivery as an alternative to the intranasal drug delivery to overcome its limitations and deliver high molecular weight (HMW) therapeutics efficiently to the brain. This approach is based on human endoscopic skull base surgical techniques in which a surgical defect is repaired by engrafting semipermeable nasal mucosa over a skull base defect. Read More

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December 2018

Altering alpha-frequency brain oscillations with rapid analog feedback-driven neurostimulation.

PLoS One 2018 5;13(12):e0207781. Epub 2018 Dec 5.

Picower Institute for Learning & Memory, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America.

Oscillations of the brain's local field potential (LFP) may coordinate neural ensembles and brain networks. It has been difficult to causally test this model or to translate its implications into treatments, because there are few reliable ways to alter LFP oscillations. We developed a closed-loop analog circuit to enhance brain oscillations by feeding them back into cortex through phase-locked transcranial electrical stimulation. Read More

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December 2018

Mid-term clinical outcomes of new generation drug-eluting stents for treatment of diffuse coronary artery disease.

Turk Kardiyol Dern Ars 2018 Dec;46(8):659-666

Department of Cardiology, Başkent University Hospital, Alanya Medical and Research Center, Alanya, Turkey.

Objective: Diffuse coronary artery disease (CAD) is a challenging issue in clinical cardiology practice. There are limited data about percutaneous revascularization in these patients.

Methods: This study was an observational clinical evaluation. Read More

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December 2018

IMPROVEMENT OF THE DERMATENSION METHOD IN THE RECONSTRUCTIVE-RECOVERY SURGERY OF DEFECTS OF SOFT TISSUES OF VARIOUS ETIOLOGY.

Georgian Med News 2018 Oct(283):7-10

Kharkov Medical Academy of Postgraduate Education, Ukraine.

The problem of treating patients with loss of the skin and with a complicated course of the wound process remains topical. The problem is that, despite the relative technical simplicity of the dermatension method, the most significant complication is the decubitus of the stretchable flap, which is associated with a relatively high incidence of acute blood circulatory disturbances in the stretch tissues due to vascular compression with an excessive amount of injected fluid. The aim of the work is to improve the method of dermatension in reconstructive and recovery surgery of soft tissue defects of various genesis by planning and implementing dermatension at all its steps with instrumental control of the process using ultrasound and ICT in a complex. Read More

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October 2018
2 Reads

THE EFFECTS OF BONE MICROSTRUCTURE ON SUBSIDENCE RISK FOR ALIF, LLIF, PLIF, AND TLIF SPINE CAGES.

J Biomech Eng 2018 Dec 5. Epub 2018 Dec 5.

U.S. Food and Drug Administration, Center for Devices and Radiological Health, Office of Science and Engineering Laboratories, Division of Applied Mechanics, Silver Spring, Maryland, 20993 USA.

Several approaches (anterior, posterior, lateral, and transforaminal) are used in lumbar fusion surgery. However, it is unclear whether one of these approaches has the greatest subsidence risk as published clinical rates of cage subsidence vary widely (7-70%). Specifically, there is limited data on how a patient's endplate morphometry and trabecular bone quality influences cage subsidence risk. Read More

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December 2018
1 Read

Design and evaluation of the Micra Transcatheter Pacing System for bradyarrhythmia management.

Future Cardiol 2018 Dec 5. Epub 2018 Dec 5.

Cardiac Rhythm Management Research Department, University Hospital Southampton NHS Foundation Trust, Southampton, UK.

Permanent cardiac pacemakers have traditionally comprised a surgically implanted subcutaneous pulse generator affixed to at least one transvenous pacing lead. Despite technological advances, implant-related complications and transvenous-lead failure rates have remained high. The Micra Transcatheter Pacing System is a miniaturized single chamber pacemaker that is implanted directly into the right ventricle, eliminating the subcutaneous pocket and creating a leadless pacemaker system. Read More

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December 2018
1 Read

Biocompatibility and immunohistochemical evaluation of a new calcium silicate-based cement, Bio-C Pulpo.

Int Endod J 2018 Dec 4. Epub 2018 Dec 4.

Department of Clinics and Surgery, School of Dentistry, Federal University of Alfenas (UNIFAL-MG), Alfenas, MG.

Aim: To evaluate the inflammatory response and ability to induce mineral deposition through histological and immunohistochemical analysis for osteocalcin (OCN), osteopontin (OPN), and bone sialoprotein (BSP) of a new calcium silicate-based cement, Bio-C Pulpo (Angelus), compared to white mineral trioxide aggregate (White MTA-Ang) (Angelus).

Methodology: Polyethylene tubes containing Bio-C Pulpo and White MTA-Ang as well as empty tubes were implanted into the dorsal connective tissue of 30 Wistar rats, which were arranged in 5 groups according to the period of analysis: 7, 15, 30, 60, and 90 days. After each experimental period, the tubes with surrounding tissue were removed and histologically processed to be analysed using haematoxylin-eosin and immunohistochemistry for the detection of OCN, OPN, and BSP. Read More

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December 2018

Primary cemented bipolar radial head prostheses for acute elbow injuries with comminuted radial head fractures: mid-term results of 37 patients.

Musculoskelet Surg 2018 Dec 4. Epub 2018 Dec 4.

Department of Trauma and Handsurgery, Heinrich Heine University Hospital Duesseldorf, Moorenstr. 5, 40225, Düsseldorf, Germany.

Background: Radial head arthroplasty represents a widely accepted treatment for elbow injuries with non-reconstructible radial head fractures. The aim of this retrospective multicenter study was to assess mid-term results of patients with clearly defined elbow injuries including type III fractures of the radial head according to Mason's classification type III after primary arthroplasty using a cemented bipolar design.

Materials And Methods: In 45 cases a primary cemented bipolar arthroplasty of the radial head was implanted for elbow injuries combined with an acute Mason type III radial head fracture. Read More

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December 2018
2 Reads

Basic Measures of Prosody in Spontaneous Speech of Children With Early and Late Cochlear Implantation.

J Speech Lang Hear Res 2018 Dec 3:1-20. Epub 2018 Dec 3.

Leiden University Centre for Linguistics, the Netherlands.

Purpose: Relative to normally hearing (NH) peers, the speech of children with cochlear implants (CIs) has been found to have deviations such as a high fundamental frequency, elevated jitter and shimmer, and inadequate intonation. However, two important dimensions of prosody (temporal and spectral) have not been systematically investigated. Given that, in general, the resolution in CI hearing is best for the temporal dimension and worst for the spectral dimension, we expected this hierarchy to be reflected in the amount of CI speech's deviation from NH speech. Read More

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December 2018

Multiple genetic mutations caused by NKX6.3 depletion contribute to gastric tumorigenesis.

Sci Rep 2018 Dec 4;8(1):17609. Epub 2018 Dec 4.

Department of Pathology, College of Medicine, The Catholic University of Korea, 222 Banpo-daero, Seocho-gu, Seoul, 06591, South Korea.

NKX family members are involved in a variety of developmental processes such as cell fate determination in the central nervous system, gastrointestinal tract, and pancreas. However, whether NKX6.3 contributes to gastric carcinogenesis remains unclear. Read More

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December 2018

Sudden-onset severe presyncope in a 67-year-old man.

Heart 2018 Dec 4. Epub 2018 Dec 4.

Cardiology Department, Addenbrooke's Hospital, Cambridge, UK.

A 67-year-old man presented to the emergency department with sudden onset of severe presyncope. He reported that he had a permanent pacemaker implanted in 2006 following atrioventricular node ablation for persistent atrial fibrillation (AF). After suffering increasing shortness of breath, he underwent upgrade to cardiac resynchronisation therapy (CRT) in 2016. Read More

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December 2018

Inferior thalamic peduncle deep brain stimulation for treatment-refractory obsessive-compulsive disorder: A phase 1 pilot trial.

Brain Stimul 2018 Nov 27. Epub 2018 Nov 27.

Division of Neurosurgery, University of Toronto, Canada. Electronic address:

Background: Several different surgical procedures targeting the limbic circuit have been utilized for severe, treatment resistant obsessive-compulsive disorder; however, there has only been limited exploration of the inferior thalamic peduncle (ITP). The aim of this study was to determine the safety and initial efficacy of ITP deep brain stimulation (DBS) in patients with severe obsessive-compulsive disorder.

Methods: Patients with severe, treatment-refractory obsessive-compulsive disorder were enrolled into this open-label phase 1 DBS pilot study. Read More

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November 2018
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Midterm Single-Center Results of Endovascular Aneurysm Repair With Additional EndoAnchors.

J Endovasc Ther 2018 Dec 4:1526602818816099. Epub 2018 Dec 4.

4 Department of Vascular Surgery, University Medical Centre Groningen, the Netherlands.

Purpose: To review midterm clinical outcomes of EndoAnchor placement during or after endovascular aneurysm repair (EVAR) or chimney EVAR (ch-EVAR).

Materials And Methods: A retrospective analysis was conducted of 51 consecutive patients [median age 75 years; 38 men] who underwent EVAR/ch-EVAR with EndoAnchor placement between June 2010 and December 2016 to prevent seal failures (31, 61%) or to treat type Ia endoleak and/or migration (20, 39%). Median aortic neck diameter was 27. Read More

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December 2018

[Comparison of the effect of navigation template assisted spinal pedicle fixation and traditional pedicle screw fixation:a Meta-analysis].

Zhongguo Gu Shang 2018 Nov;31(11):1069-1076

Department of Orthopaedics, the Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710004, Shaanxi, China;

Objective: To systematically evaluate the efficacy of rapid prototyping drill navigation template-assisted pedicle screw fixation and traditional anatomic landmark-based fixation in the treatment of spinal disease by accessing and searching some relevant literatures home and abroad.

Methods: Randomized Controlled Trials (RCTs) and prospective case-control studies or retrospective case-control studies about rapid prototyping drill templates-assisted pedicle screw fixation and traditional anatomic landmark-based fixation for the treatment of spinal disease were searched electronically in PubMed, The Cochrane Library(Issue 5, 2017), Clinical Trial, Google Scholar, Web of Science, CNKI, Wanfang database and VIP database before June 2017. According to the inclusion and exclusion criteria, two researchers independently screened the literatures, and extracted the data. Read More

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November 2018
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Potent anti-cancer activity of Alnus nitida against lung cancer cells; in vitro and in vivo studies.

Biomed Pharmacother 2018 Nov 30;110:254-264. Epub 2018 Nov 30.

Department of Biochemistry, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad, 45320, Pakistan. Electronic address:

Alnus nitida is used for multiple disorders in norther areas of Pakistan. In this study we have evaluated methanol extract of leaf (ANL) and stem bark (ANB) of A. nitida against two lung cancer cell lines; A-549 and H460 (Human non-small lung cancer cell lines) during in vitro assays for growth inhibition. Read More

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November 2018
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Hemodynamic and neuronal responses to cocaine differ in awake versus anesthetized animals: Optical brain imaging study.

Neuroimage 2018 Dec 1. Epub 2018 Dec 1.

Department of Biomedical Engineering, Stony Brook University, Stony Brook, NY, 11794, USA. Electronic address:

Cocaine is a highly addictive drug with complex pharmacological effects. Most preclinical imaging studies investigating the effects of cocaine in the brain have been performed under anesthesia, which confounds findings. To tackle this problem, we used optical imaging to compare the effects of cocaine in the awake versus the anesthetized state. Read More

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December 2018
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