1,958 results match your criteria Impetigo
J Med Microbiol 2018 Nov 12. Epub 2018 Nov 12.
42nd Department of Paediatrics, School of Medicine, National and Kapodistrian University of Athens, Greece.
A sharp increase in staphylococcal scalded skin syndrome (SSSS) cases has been recorded in our settings since 2015, with 31 cases having been documented during the period 2014-2017. The molecular investigation of strains from the above period showed the emergence of a methicillin-susceptible, mupirocin- and fusidic acid-resistant Staphyloccocus aureus clone that belongs to the ST121 complex and carries both epidermolysin (eta/etb) genes. We concluded that the SSSS caused by the newly emerged, highly virulent community-associated-methicillin sensitive S. Read More
Hong Kong Med J 2018 Nov 9. Epub 2018 Nov 9.
Department of Paediatrics, Alberta Children's Hospital, The University of Calgary, Calgary, Alberta, Canada.
Group A β-haemolytic or is a gram-positive coccus that tends to grow in chains. is the cause of many important human diseases, ranging from pharyngitis and mild superficial skin infections to life-threatening systemic diseases. Infections typically begin in the throat or skin. Read More
Vaccine 2018 Nov 3;36(50):7618-7624. Epub 2018 Nov 3.
Murdoch Children's Research Institute, The Royal Children's Hospital, Melbourne, Australia; Centre for International Child Health, University of Melbourne, Australia; Department of Paediatrics, University of Melbourne, Royal Children's Hospital Melbourne, Parkville, Australia.
Sustained control of group A Streptococcus (GAS) infections in settings of poverty has proven to be challenging, and an effective vaccine may be the most practical long-term strategy to reduce GAS-related disease burden. Candidate GAS vaccines based on the J8 peptide have demonstrated promising immunogenicity in mice, however, less is known about the role of J8 antibodies in the human immune response to GAS infection. We analysed the stimulation of J8 antibodies in response to infection, and the role of existing J8 antibodies in protection against subsequent infection, using data collected in the Fijian population: (1) cross sectional population serosurvey; (2) paired serum collection for assessment of M-specific and J8 antibody responses; and (3) longitudinal assessment of GAS infection and immunity. Read More
J Drugs Dermatol 2018 Oct;17(10):1051-1057
Ozenoxacin is a novel topical antibacterial agent with potent bactericidal activity against Gram-positive bacteria that has been developed as a 1% cream for treatment of impetigo. This article presents pooled results of pivotal clinical trials of ozenoxacin with the objective of evaluating the efficacy, safety, and tolerability of ozenoxacin 1% cream after twice-daily topical treatment for 5 days in patients with impetigo. A pooled analysis was performed of individual patient data from two multicenter, randomized, double-blind, vehicle-controlled phase 3 registration studies conducted in patients with impetigo. Read More
Fam Pract 2018 Oct 19. Epub 2018 Oct 19.
Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands.
Background: There is a lack of recently published data on impetigo presentation incidence and treatment practices in the routine Western European primary care setting.
Objectives: To investigate impetigo incidence, treatments and recurrence in primary care in the Netherlands.
Methods: A retrospective, observational study. Read More
Emerg Med Clin North Am 2018 Nov;36(4):723-750
Department of Emergency Medicine, Highland Hospital, 1411 East 31st Street, Oakland, CA 94602, USA. Electronic address:
This article covers the diagnosis and treatment of skin and soft tissue infections commonly encountered in the emergency department: impetigo, cutaneous abscesses, purulent cellulitis, nonpurulent cellulitis, and necrotizing skin and soft tissue infections. Most purulent infections in the United States are caused by methicillin-resistant Staphylococcus aureus. For abscesses, we emphasize the importance of incision and drainage. Read More
J Infect Chemother 2018 Sep 29. Epub 2018 Sep 29.
Department of Microbiology, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, 1432-1 Horinouchi, Hachioji, Tokyo 192-0392, Japan.
Community-onset methicillin-resistant Staphylococcus aureus (CO-MRSA) is a causative agent of intractable skin infections. In general, clinical symptoms of hospital outpatients with skin infections are severer than those of clinic patients. Hence, molecular epidemiological features of the CO-MRSA strains from hospital outpatients are predicted to be different from those of clinic patients. Read More
Trop Med Infect Dis 2018 Sep 5;3(3). Epub 2018 Sep 5.
Tropical Diseases, Murdoch Children's Research Institute, Parkville VIC 3052, Australia.
Scabies is a neglected tropical disease of the skin, causing severe itching and stigmatizing skin lesions. Further, scabies leads to impetigo, severe bacterial infections, and post-infectious complications. Around 200 million people are affected, particularly among disadvantaged populations living in crowded conditions in tropical areas. Read More
Front Pediatr 2018 11;6:248. Epub 2018 Sep 11.
Department of Immunology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil.
Chronic granulomatous disease (CGD) is an innate immune deficiency of phagocytic cells caused by mutations that affect components of the NADPH oxidase system, with resulting impairment in reactive oxygen species production. Patients with CGD are susceptible to recurrent infections and hyperinflammatory responses. Mutations in lead to the X-linked form of CGD and are responsible for ~ 70% of cases. Read More
Int J Dermatol 2018 Sep 24. Epub 2018 Sep 24.
Head of the Pediatrics Department, Hospital Interzonal General de Agudos Presidente Perón, Sarandí, Avellaneda, Buenos Aires, Argentina.
Background: Infectious skin disorders (ISDs) are commonly seen in pediatric emergency departments (PED), however the exact frequency is unknown. We provide an accurate evaluation of the incidence and characteristics of ISDs diagnosed in a PED from Buenos Aires, Argentina, over a 1-year period.
Methods: Prospectively, descriptive study of children evaluated in the PED with ISDs during 2016. Read More
G Ital Dermatol Venereol 2018 Sep 18. Epub 2018 Sep 18.
Department of Pathophysiology and Transplantation, Università degli Studi di Milano, I.R.C.C.S. Foundation, Cà Granda Ospedale Maggiore Policlinico, Milan, Italy.
Clin Dermatol 2018 Sep - Oct;36(5):631-640. Epub 2018 Jun 1.
Department of Dermatology, Mt Sinai West, Icahn School of Medicine at Mt Sinai, New York, NY. Electronic address:
Atopic dermatitis is a common chronic pruritic inflammatory skin disorder, characterized by an abnormal skin barrier, immune dysfunction, and an altered skin microbiome. Atopic dermatitis may be seen in conjunction with a variety of other skin disorders due to the complex pathogenesis of atopic dermatitis, involving genetic and environmental factors that are associated with immune dysfunction, barrier defects, and altered skin microbiomes. Skin disorders associated with atopic dermatitis include diseases sharing similar genetic origins like ichthyosis vulgaris, infectious diseases such as impetigo, and eczema herpeticum, in addition to the cutaneous autoimmune diseases, alopecia areata, and vitiligo. Read More
BMJ Case Rep 2018 Sep 12;2018. Epub 2018 Sep 12.
Department of Ophthalmology, Penn State Health Milton S Hershey Medical Center, Hershey, Pennsylvania, USA.
A 26-year-old Caucasian man with no previous history of chemical injury presenting with an inability to open his right eye was investigated for mucous membrane pemphigoid and treated. Examination was notable for symblepharon of the right eye and impetigo-like lesions on the face and neck. A biopsy with immunohistochemical analysis was significant for linear deposits of C3 and immunoglobulin G at the level of the epithelial basement membrane, confirming the diagnosis of mucous membrane pemphigoid. Read More
N Z Med J 2018 Aug 31;131(1481):78-81. Epub 2018 Aug 31.
Medical Officer, Auckland Regional Public Health Service, Greenlane Clinical Centre, Greenlane West, Auckland.
Mikrobiyol Bul 2018 Jul;52(3):233-246
Selçuk University Faculty of Medicine, Department of Medical Microbiology, Konya, Turkey.
Streptococcus pyogenes is an important bacterial pathogen that colonizes the throat and skin of human beings and causes a wide variety of diseases ranging from mild infections like pharyngitis, tonsillitis and impetigo to severe invasive infections such streptococcal toxic shock syndrome, septicemia, and necrotizing fasciitis, and produces a wide variety of virulence factors. The aim of this study was to investigate the antibiotic resistance, virulence genes; [pyrogenic exotoxin genes (speA, C, G, H, I, J, K, L, M, smeZ and ssa), deoxyribonuclease genes (sdaB, spd3, sdc ve sdaD), protease genes (speB, spyCEP ve scpA) and inhibitor genes (mac and sic)] of S.pyogenes strains isolated from throat cultures of patients with symptomatic tonsillo-pharyngitis and typing by multiple locus variable number tandem repeat fingerprinting (MLVF) method. Read More
Prim Care 2018 Sep;45(3):433-454
Department of Family Medicine, Tidelands Health MUSC Family Medicine Residency Program, 4320 Holmestown Road, Myrtle Beach, SC 29588, USA.
The primary care provider will commonly see skin and soft tissue infections in the outpatient setting. Skin and soft tissue infections range from the uncomplicated impetigo to the potentially lethal necrotizing fasciitis. This article reviews these infections based on their underlying etiology: bacterial, fungal, and viral causes. Read More
Eur J Dermatol 2018 Jun;28(3):381-382
Department of Dermatology, Yamanashi Prefectural Central Hospital, Yamanashi, Japan.
Int J Dermatol 2018 11 10;57(11):e141-e142. Epub 2018 Aug 10.
Department of Dermatology, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Biochem J 2018 Sep 11;475(17):2847-2860. Epub 2018 Sep 11.
Department of Biological Sciences, 14 Science Drive 4, National University of Singapore, Singapore 117543
Group A Streptococcus (GAS; ) causes a wide range of infections, including pharyngitis, impetigo, and necrotizing fasciitis, and results in over half a million deaths annually. GAS ScpC (SpyCEP), a 180-kDa surface-exposed, subtilisin-like serine protease, acts as an essential virulence factor that helps evade the innate immune response by cleaving and inactivating C-X-C chemokines. ScpC is thus a key candidate for the development of a vaccine against GAS and other pathogenic streptococcal species. Read More
PLoS Negl Trop Dis 2018 07 25;12(7):e0006668. Epub 2018 Jul 25.
Victorian Infectious Disease Reference Laboratory, The Royal Melbourne Hospital and The University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, Australia.
Background: Skin sores caused by Group A streptococcus (GAS) infection are a major public health problem in remote Aboriginal communities. Skin sores are often associated with scabies, which is evident in scabies intervention programs where a significant reduction of skin sores is seen after focusing solely on scabies control. Our study quantifies the strength of association between skin sores and scabies among Aboriginal children from the East Arnhem region in the Northern Territory. Read More
Int J Dermatol 2018 Jul 20. Epub 2018 Jul 20.
Department of Dermatology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, Japan.
Clin Infect Dis 2018 Jul 7. Epub 2018 Jul 7.
Group A Streptococcal Research Group, Murdoch Children's Research Institute, Melbourne, Victoria, Australia.
Background: Scabies is a public health problem in many countries, with impetigo and its complications important consequences. Ivermectin based mass drug administration (MDA) reduces the prevalence of scabies and, to a lesser extent, impetigo. We studied the impact of co-administering azithromycin on the prevalence of impetigo and antimicrobial resistance. Read More
Ann Pharmacother 2018 Dec 2;52(12):1233-1237. Epub 2018 Jul 2.
1 Auburn University Harrison School of Pharmacy, Auburn, AL, USA.
Objective: To review the data supporting Food and Drug Administration (FDA) labeling of ozenoxacin and evaluate its place in therapy for impetigo.
Data Sources: A literature search was conducted using PubMed (1966 to May 2018) and Google Scholar (2000 to May 2018) with the search terms ozenoxacin, T-3912, and GF-001001-00. Other resources included clinicaltrials. Read More
Dermatol Clin 2018 Jul 1;36(3):301-308. Epub 2018 May 1.
Dermatology Department, AP-HP, Hôpital Henri Mondor, 51 avenue du Maréchal de Lattre de Tassigny, 94010 Créteil, France; EpiDermE, Epidé miologie en Dermatologie et Evaluation des Thé rapeutiques, Université Paris-Est Créteil, EA 7379, 9400 Créteil, France.
Itch is the cardinal symptom of scabies, present in more than 90% of the cases, generalized and intense, worsening at night, and often sparing the head. The primary complications of the itch in scabies are secondary bacterial infections and psychosocial issues leading to impairment on life quality. Currently, there are no specific data analyzing mechanisms of the itch in scabies, but the latest progress made in the understanding of host-mite interactions may help to improve understanding. Read More
JAMA Dermatol 2018 Jul;154(7):806-813
John P. and Katherine G. McGovern Medical School, Houston, Texas.
Importance: Ozenoxacin, a novel topical antibacterial agent with potent bactericidal activity against gram-positive bacteria, has been developed as a cream with 1% active drug for the treatment of impetigo, a highly contagious bacterial skin infection.
Objectives: To evaluate the efficacy, safety, and tolerability of ozenoxacin cream, 1%, after 5-day twice-daily topical treatment in patients with impetigo.
Design, Setting, And Participants: This randomized, double-blind, vehicle-controlled clinical trial included patients 2 months or older with impetigo who were enrolled at centers in 6 countries from June 2, 2014, through May 30, 2015. Read More
J Dermatol 2018 Aug 13;45(8):994-999. Epub 2018 Jun 13.
Department of Dermatology, Rambam Health Care Campus, Technion, Haifa, Israel.
Staphylococcus lugdunensis is an emerging pathogen in skin and soft tissue infections that was previously considered a commensal. The aim of this study was to elucidate the characteristics of skin infections by S. lugdunensis and its appropriate management, in a tertiary referral medical center. Read More
Clin Exp Dermatol 2019 Jan 12;44(1):52-57. Epub 2018 Jun 12.
Department of Dermatology, Peking Union Medical College Hospital, Beijing, China.
Background: Palmoplantar pustulosis (PPP) is a refractory, nonbacterial impetigo confined to the palms and soles. Its pathogenesis is still obscure, but it may be associated with the large eccrine sweat glands and pores of palmoplantar skin. PPP is considered to be a localized pustular psoriasis. Read More
PLoS Negl Trop Dis 2018 05 31;12(5):e0006400. Epub 2018 May 31.
Paediatric Department, Royal Darwin Hospital, Darwin, Australia.
Introduction: Scabies and impetigo are common and important skin conditions which are often neglected in developing countries. Limited data have been published on the prevalence of scabies and impetigo in Timor-Leste. Sequelae including cellulitis, bacteraemia, nephritis, acute rheumatic fever and rheumatic heart disease contribute significantly to the burden of disease. Read More
Dermatol Res Pract 2018 4;2018:5801280. Epub 2018 Apr 4.
Skin Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Impetigo herpetiformis (IH) is among rare dermatosis of pregnancy, which is currently considered as a form of generalized pustular psoriasis. It is diagnosed by characteristic lesions of erythematous patches and grouped pustules mostly in the third trimester of pregnancy and may have systemic associations. A variety of complications have been reported in the course of IH. Read More
Recent Pat Antiinfect Drug Discov 2018 May 28. Epub 2018 May 28.
University Institute of Pharmaceutical Sciences, UGC Centre of Advanced Studies, Panjab University, Chandigarh. India.
Background: Topical infections, involving a number of diseases such as impetigo, eczema, pustular acne, psoriasis and infected seborrheic dermatitis are one among the many challenges to health which stand out for their profound impact on human species. The treatment of topical infections has always been a difficult proposition because of the lack of efficacy of existing anti-infectives, longer period of treatment and yet incomplete recovery. The increasing emergence of antibiotic resistant bacterial strains like Staphylococcus aureus, Methicillin-Resistant Staphylococcus aureus (MRSA) and Pseudomonas aeruginosa undermine the need of development of new delivery systems to enhance the therapeutic efficacy of existing topical anti-infectives. Read More
Ophthalmology 2018 Jun;125(6):798
Massachusetts Eye and Ear Infirmary, Boston, Massachusetts.
BMJ Case Rep 2018 May 14;2018. Epub 2018 May 14.
Department of Medicine, Faculty of Medicine, Dalhousie University, Halifax, Nova Scotia, Canada.
We present the case of a 3-month-old infant with atopic dermatitis who developed severe impetigo. The child was born to Syrian refugees shortly after they arrived in Canada. The case demonstrates the rapid and nearly complete resolution of dramatic skin findings after a course of hydrocortisone ointment and oral antibiotics with adjuvant measures. Read More
Cutis 2018 Apr;101(4):278-280
Department of Dermatology, University of Rochester, New York, USA.
Pustular psoriasis of pregnancy (PPP), also known as impetigo herpetiformis, is a rare condition that affects women in the third trimester of pregnancy through the postpartum period. The relative infrequency of PPP presents both clinical and pathologic challenges in the diagnosis and management of this condition. We report a case of a woman who presented at 32 weeks' gestation with a generalized rash demonstrating clinicopathologic features consistent with PPP. Read More
Future Microbiol 2018 05;13:3-19
Medical Department, Ferrer Internacional, Barcelona, Spain.
Aim: To compare the in vitro activity of the anti-impetigo agent, ozenoxacin, and other antimicrobial agents against Gram-positive clinical isolates from skin and soft tissue infections.
Materials & Methods: Isolates were collected in two studies: 1097 isolates from 49 centers during 2009-2010 and 1031 isolates from ten centers during 2014. Minimum inhibitory concentrations were determined for 18 and 11 antimicrobials in these studies, respectively, using standard broth microdilution methods. Read More
Future Microbiol 2018 05;13:1-2
Spherium Biomed, Barcelona, Spain.
Future Microbiol 2018 05;13:21-30
Medical Department, Ferrer Internacional, Barcelona, Spain.
Aim: To assess different concentrations and formulations of topical ozenoxacin using a mouse model of Staphylococcus aureus dermal infection for identification of the best formulation for treating patients with impetigo.
Materials & Methods: The efficacy of ozenoxacin formulations was compared with vehicle control, mupirocin and retapamulin ointments in a mouse model.
Results: The most effective concentrations of ozenoxacin for reducing S. Read More
Future Microbiol 2018 05;13:31-40
Medical Department, Ferrer Internacional SA, Barcelona, Spain.
Aim: Ozenoxacin is a nonfluorinated quinolone antibacterial approved for topical treatment of impetigo. Because quinolones have known chondrotoxic effects in juvenile animals, the potential toxicity of ozenoxacin was assessed in preclinical studies.
Materials & Methods: Ozenoxacin or ofloxacin (300 mg/kg/day for 5 days, for each compound) was orally administered to juvenile rats, and oral ozenoxacin (10-100 mg/kg/day for 14 days) was administered to juvenile dogs. Read More
Curr Drug Discov Technol 2018 May 2. Epub 2018 May 2.
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, IFTM University, Moradabad - 244102. India.
Objective: Ozenoxacin is one of the potent quinolone antibiotics, recently approved by the United States Food and Drug Administration (USFDA) with reported pharmacology to treat the impetigo. The demand for better acting topical formulation is increasing day by day. The present review is an attempt to summarize the facts behind the chemistry and biological applications of Ozenoxacin. Read More
Contact Dermatitis 2018 May;78(5):359-361
Lund University, Skane University Hospital, Department of Occupational and Environmental Dermatology, Malmö, 205 02, Sweden.
Ann Dermatol 2018 Apr 21;30(2):186-191. Epub 2018 Feb 21.
Department of Dermatology, SMG-SNU Boramae Medical Center, Seoul, Korea.
Background: Bacterial skin infections occur secondarily in conditions involving a vulnerable skin barrier such as atopic eczema, as well as primarily such as impetigo. They are mainly caused by and . Recently, the prevalence of methicillin-resistant has been increasing. Read More
J Eur Acad Dermatol Venereol 2018 Oct 11;32(10):1645-1651. Epub 2018 Apr 11.
Department of Dermatology, Rutgers-New Jersey Medical School, Newark, NJ, USA.
Generalized pustular psoriasis (GPP) is a subtype of pustular psoriasis characterized by painful and occasionally disfiguring cutaneous manifestations with sepsis-like systemic symptoms. Affecting any age and race, GPP can occur with other forms of psoriasis or by itself. Stimuli for flares include medications, infections and environmental triggers. Read More
Clin Dermatol 2018 Mar - Apr;36(2):188-196. Epub 2017 Oct 3.
Sector of Dermatology and Post-Graduation Course in Dermatology, University Hospital and School of Medicine, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil. Electronic address:
Dermatologists must be familiar with the peculiarities of the micro-organisms that may affect the elderly, in order to optimize the diagnosis and treatment of infections, which may affect their skin, especially because the world population is rapidly aging. It is estimated that there will be 434 million individuals over 80 years of age in 2050. Since the elderly population is rapidly increasing and their infections are usually more severe and different from those observed in younger adults, it leads to a statistical increase of the rates regarding hospitalization and mortality caused by infectious diseases among people over 85 years. Read More
Int J Womens Health 2018 26;10:109-115. Epub 2018 Feb 26.
Department of Dermatology, University of California, San Francisco, CA, USA.
Pustular psoriasis of pregnancy (PPP) is a life-threatening condition for both the pregnant mother and fetus, and must be efficiently and accurately diagnosed and treated. This condition has historically been classified as a unique, separate dermatosis of pregnancy. However, current opinion and data suggest that it may be a variant of generalized pustular psoriasis. Read More
J Zoo Wildl Med 2018 Mar;49(1):206-209
Impetigo is a bacterial infection of the superficial layer of the epidermis with crusting or bullae caused by Streptococcus spp., Staphylococcus spp., or both. Read More
Vaccine 2018 06 26;36(24):3397-3405. Epub 2018 Feb 26.
Group A Streptococcal Research Group, Murdoch Children's Research Institute, Melbourne 3052, Australia.
While progress towards a Group A Streptococcus (GAS) vaccine has been stalled by a combination of scientific, regulatory, and commercial barriers, the problem persists. The high and globally-distributed burden of disease attributable to GAS makes vaccination an imperative global public health goal. Advances across a range of scientific disciplines in understanding GAS diseases have made the goal a realistic one and focused attention on the need for coordinated global action. Read More
J Antimicrob Chemother 2018 Feb;73(suppl_2):ii11-ii18
Modelling and Economics Unit, National Infection Service, Public Health England, London NW9 5EQ, UK.
Objectives: To assess the appropriateness of prescribing systemic antibiotics for different clinical conditions in primary care, and to quantify 'ideal' antibiotic prescribing proportions in conditions for which antibiotic treatment is sometimes but not always indicated.
Methods: Prescribing guidelines were consulted to define the appropriateness of antibiotic therapy for the conditions that resulted in antibiotic prescriptions between 2013 and 2015 in The Health Improvement Network (THIN) primary care database. The opinions of subject experts were then formally elicited to quantify ideal antibiotic prescribing proportions for 10 common conditions. Read More
J Antimicrob Chemother 2018 Feb;73(suppl_2):19-26
Modelling and Economics Unit, National Infection Service, Public Health England, London, UK.
Objectives: Previous work based on guidelines and expert opinion identified 'ideal' prescribing proportions-the overall proportion of consultations that should result in an antibiotic prescription-for common infectious conditions. Here, actual condition-specific prescribing proportions in primary care in England were compared with ideal prescribing proportions identified by experts.
Methods: All recorded consultations for common infectious conditions (cough, bronchitis, exacerbations of asthma or chronic obstructive pulmonary disease, sore throat, rhinosinusitis, otitis media, lower respiratory tract infection, upper respiratory tract infection, influenza-like illness, urinary tract infection, impetigo, acne, gastroenteritis) for 2013-15 were extracted from The Health Improvement Network (THIN) database. Read More
BMJ Open 2018 02 22;8(2):e020203. Epub 2018 Feb 22.
Modelling and Economics Unit, National Infection Service, Public Health England, London, UK.
Objectives: To explore the causes of the gender gap in antibiotic prescribing, and to determine whether women are more likely than men to receive an antibiotic prescription per consultation.
Design: Cross-sectional analysis of routinely collected electronic medical records from The Health Improvement Network (THIN).
Setting: English primary care. Read More
J Dermatol Sci 2018 May 1;90(2):105-111. Epub 2018 Feb 1.
Department of Dermatology, Fujita Health University School of Medicine, Toyoake, Japan.
Classifying inflammatory skin diseases is challenging, especially for the expanding group of disorders triggered by genetic factors resulting in hyperactivated innate immunity that result in overlapping patterns of dermal and epidermal inflammation with hyperkeratosis. For such conditions, the umbrella term "autoinflammatory keratinization diseases" (AIKD) has been proposed. AIKD encompasses diseases with mixed pathomechanisms of autoinflammation and autoimmunity, and includes IL-36 receptor antagonist (IL-36Ra)-related pustulosis, CARD14-mediated pustular psoriasis, pityriasis rubra pilaris (PRP) type V, and familial keratosis lichenoides chronica (KLC). Read More
Front Cell Infect Microbiol 2018 24;8:10. Epub 2018 Jan 24.
Department of Oral and Molecular Microbiology, Osaka University Graduate School of Dentistry, Osaka, Japan.
is responsible for a wide variety of cutaneous infections ranging from superficial impetigo to fulminant invasive necrotizing fasciitis. Dysfunction of desmosomes is associated with the pathogenesis of cutaneous diseases. We identified streptococcal pyrogenic exotoxin B (SpeB) as a proteolytic factor that cleaves the extracellular domains of desmoglein 1 and 3. Read More