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    Understanding the gender gap in antibiotic prescribing: a cross-sectional analysis of English primary care.
    BMJ Open 2018 Feb 22;8(2):e020203. Epub 2018 Feb 22.
    Modelling and Economics Unit, National Infection Service, Public Health England, London, UK.
    Objectives: To explore the causes of the gender gap in antibiotic prescribing, and to determine whether women are more likely than men to receive an antibiotic prescription per consultation.

    Design: Cross-sectional analysis of routinely collected electronic medical records from The Health Improvement Network (THIN).

    Setting: English primary care. Read More

    Autoinflammatory keratinization diseases: An emerging concept encompassing various inflammatory keratinization disorders of the skin.
    J Dermatol Sci 2018 Feb 1. Epub 2018 Feb 1.
    Department of Dermatology, Fujita Health University School of Medicine, Toyoake, Japan.
    Classifying inflammatory skin diseases is challenging, especially for the expanding group of disorders triggered by genetic factors resulting in hyperactivated innate immunity that result in overlapping patterns of dermal and epidermal inflammation with hyperkeratosis. For such conditions, the umbrella term "autoinflammatory keratinization diseases" (AIKD) has been proposed. AIKD encompasses diseases with mixed pathomechanisms of autoinflammation and autoimmunity, and includes IL-36 receptor antagonist (IL-36Ra)-related pustulosis, CARD14-mediated pustular psoriasis, pityriasis rubra pilaris (PRP) type V, and familial keratosis lichenoides chronica (KLC). Read More

    Streptococcal Cysteine Protease-Mediated Cleavage of Desmogleins Is Involved in the Pathogenesis of Cutaneous Infection.
    Front Cell Infect Microbiol 2018 24;8:10. Epub 2018 Jan 24.
    Department of Oral and Molecular Microbiology, Osaka University Graduate School of Dentistry, Osaka, Japan.
    is responsible for a wide variety of cutaneous infections ranging from superficial impetigo to fulminant invasive necrotizing fasciitis. Dysfunction of desmosomes is associated with the pathogenesis of cutaneous diseases. We identified streptococcal pyrogenic exotoxin B (SpeB) as a proteolytic factor that cleaves the extracellular domains of desmoglein 1 and 3. Read More

    Impact of climate change on dermatological conditions related to flooding: update from the International Society of Dermatology Climate Change Committee.
    Int J Dermatol 2018 Jan 29. Epub 2018 Jan 29.
    Department of Dermatology, Mayo Clinic in Minnesota, Rochester, Minnesota, USA.
    Climate change contributes to the increase in severity and frequency of flooding, which is the most frequent and deadly disaster worldwide. Flood-related damage can be very severe and include health effects. Among those health impacts, dermatological diseases are one of the most frequently encountered. Read More

    Building capacity in primary care: the implementation of a novel 'Pharmacy First' scheme for the management of UTI, impetigo and COPD exacerbation.
    Prim Health Care Res Dev 2018 Jan 24:1-11. Epub 2018 Jan 24.
    5Professor,Postgraduate Pharmacy Dean, NHS Education for Scotland,Scotland.
    Aim This service aimed to improve patient access to treatment for urinary tract infections (UTI), impetigo and exacerbation of chronic obstructive pulmonary disease (COPD) and relieve pressure on general practice and out of hours services.

    Background: In 2016, a service (Pharmacy First) was introduced in Forth Valley for the management of UTI, impetigo and exacerbation of COPD using patient group directions in community pharmacies. Trained pharmacists supplied a limited range of prescription medicines. Read More

    Unravelling the metabolic routes of retapamulin: insights into drug development of pleuromutilins.
    Antimicrob Agents Chemother 2018 Jan 22. Epub 2018 Jan 22.
    Institute of Apicultural Research, Chinese Academy of Agricultural Sciences, Key Laboratory of Bee Products for Quality and Safety Control; Laboratory of Risk Assessment for Quality and Safety of Bee Products; Bee Product Quality Supervision and Testing Center, Ministry of Agriculture, Beijing 100093, People's Republic of China
    Retapamulin, a semi-synthetic pleuromutilin derivative, is exclusively used for the topical short-term medication of impetigo and staphylococcal infections. In the present study, we report that retapamulin is adequately and rapidly metabolizedvia various metabolic pathways such as hydroxylation, including mono-, di- and tri-hydroxylation and demethylation. Like tiamulin and valnemulin, the major metabolic routes of retapamulin were hydroxylation at the 2β and 8α positions of the mutilin moiety. Read More

    Clinical Guidelines for the Antibiotic Treatment for Community-Acquired Skin and Soft Tissue Infection.
    Infect Chemother 2017 Dec;49(4):301-325
    Department of Internal Medicine, Inje University Ilsan Paik Hospital, Goyang, Korea.
    Skin and soft tissue infection (SSTI) is common and important infectious disease. This work represents an update to 2012 Korean guideline for SSTI. The present guideline was developed by the adaptation method. Read More

    Sulfamethoxazole-Trimethoprim (Cotrimoxazole) for Skin and Soft Tissue Infections Including Impetigo, Cellulitis, and Abscess.
    Open Forum Infect Dis 2017 2;4(4):ofx232. Epub 2017 Nov 2.
    Menzies School of Health Research, Charles Darwin University, North Territory, Australia.
    Skin and soft tissue infections (SSTI) affect millions of people globally, which represents a significant burden on ambulatory care and hospital settings. The role of sulfamethoxazole-trimethoprim (SXT) in SSTI treatment, particularly when group A(GAS) is involved, is controversial. We conducted a systematic review of clinical trials and observational studies that address the utility of SXT for SSTI treatment, caused by either GAS or, including methicillin-resistant (MRSA). Read More

    What's eating you? scabies in the developing world.
    Cutis 2017 Nov;100(5):287-289
    Department of Dermatology and Dermatologic Surgery, Medical University of South Carolina, Charleston, USA.
    Scabies infestation is a major cause of impetigo and subsequent renal failure in the developing world, and efforts to eradicate widespread infestation are underway. Ivermectin, topical sulfur, and topical benzyl benzoate often are used to treat widespread outbreaks. Read More

    Hospital admissions for skin infections among Western Australian children and adolescents from 1996 to 2012.
    PLoS One 2017 30;12(11):e0188803. Epub 2017 Nov 30.
    Wesfarmers Centre for Vaccines and Infectious Diseases, Telethon Kids Institute, The University of Western Australia, Perth, Western Australia, Australia.
    The objective of this study was to describe the occurrence of skin infection associated hospitalizations in children born in Western Australia (WA). We conducted a retrospective cohort study of all children born in WA between 1996 and 2012 (n = 469,589). Of these, 31,348 (6. Read More

    The Selective Interaction ofOil vs. Human Streptococci, an Old Functional Food Revisited with New Tools.
    Front Microbiol 2017 24;8:2067. Epub 2017 Oct 24.
    National Research Council of Italy, Sassari, Italy.
    berry oil (LBO) represents a typical vegetal product of the Mediterranean basin that has been formally used in traditional cuisine for 100s of years. In addition to its interesting alimentary properties, this product could represent an interesting candidate in the field of research on the study of new anti-infective agents. In fact, in Mediterranean countries, lentisk oil still continues to be widely used in folk medicine for oral and skin affections, in particular, acute gingivitis, pediatric skin infections such as impetigo and foot plaques, and biofilm related infections often associated withspp. Read More

    Erythematous plaques and papules on a premature infant.
    J Am Acad Dermatol 2017 Apr;76(4):e111-e112
    Department of Medicine (Dermatology), Vanderbilt University Medical Center, Nashville, TN.
    A 2240 gram boy was born at 33.2 weeks gestation with nonblanching, deeply erythematous plaques and papules on the back, flanks, and scalp (Figure 1). His mother was GBS positive and on antibiotic suppression for prior cutaneous MRSA and urinary tract infections. Read More

    Impetigo: A need for new therapies in a world of increasing antimicrobial resistance.
    J Clin Pharm Ther 2018 Feb 23;43(1):150-153. Epub 2017 Oct 23.
    Faculty of Health, University of Canberra, Bruce, ACT, Australia.
    What Is Known And Objective: Impetigo is a highly contagious bacterial skin infection and is one of the most common skin infections in children. Antibiotics are the first-line treatment when multiple lesions exist, but with an increasing prevalence of antibiotic-resistant bacteria the successful management of impetigo in the future is an area of concern.

    Comment: Current treatment options that favour the use of oral antibiotic therapy are increasingly problematic. Read More

    Immune Cross-Opsonization Within emm Clusters Following Group A Streptococcus Skin Infection: Broadening the Scope of Type-Specific Immunity.
    Clin Infect Dis 2017 Oct;65(9):1523-1531
    Group A Streptococcus Research Group, Murdoch Childrens Research Institute, Melbourne, Australia.
    Background: Group A Streptococcus (GAS) skin infections are particularly prevalent in developing nations. The GAS M protein, by which strains are differentiated into >220 different emm types, is immunogenic and elicits protective antibodies. A major obstacle for vaccine development has been the traditional understanding that immunity following infection is restricted to a single emm type. Read More

    Efficacy and tolerability of liposomal polyvinylpyrrolidone-iodine hydrogel for the localized treatment of chronic infective, inflammatory, dermatoses: an uncontrolled pilot study.
    Clin Cosmet Investig Dermatol 2017 22;10:373-384. Epub 2017 Sep 22.
    Mundipharma Research GmbH & Co.KG, Limburg (Lahn), Germany.
    Infection is common in many chronic, inflammatory skin conditions but is often difficult to treat, in part due to growing bacterial resistance to antibiotics. Liposomal polyvinyl-pyrrolidone (PVP)-iodine hydrogel has a unique mode of action, combining the antiseptic and anti-inflammatory actions of PVP-iodine with the drug delivery and moisturizing properties of liposomes. We investigated the utility of liposomal PVP-iodine to treat infective dermatoses. Read More

    Recurrent impetigo herpetiformis: case report.
    Pan Afr Med J 2017 24;27:219. Epub 2017 Jul 24.
    Faculty of Health Sciences, Egerton University, Njoro, Kenya.
    Impetigo herpetiformis (pustular psoriasis of pregnancy) is a rare dermatosis of pregnancy that typically starts in the 2half of pregnancy and resolves postpartum. It may recur in subsequent pregnancies. I present a case of 23 year old female gravida 4 para 3 with recurrent impetigo herpetiformis at 26 weeks gestation. Read More

    Assessment of Cpa, Scl1 and Scl2 in clinical group A streptococcus isolates and patients from north India: an evaluation of the host pathogen interaction.
    Res Microbiol 2018 Jan 30;169(1):11-19. Epub 2017 Sep 30.
    Department of Experimental Medicine and Biotechnology, Postgraduate Institute of Medical Education and Research, Chandigarh 160012, India. Electronic address:
    Group A streptococcus (GAS) infection remains a major concern due to multiple diseases including pharyngitis, impetigo, acute rheumatic fever (ARF) and rheumatic heart disease (RHD). It uses different adhesins and virulence factors like Cpa (collagen binding protein) and Scl (collagen-like protein) in its pathogenicity. Scl having similarities with human collagen may contribute to inducing autoimmunity in the host. Read More

    [Acute skin infections and their imitators in children : A photo quiz].
    Hautarzt 2017 Oct;68(10):774-783
    Abteilung pädiatrische Dermatologie, Universitäts-Kinderspital Zürich, Steinwiesstrasse 75, 8032, Zürich, Schweiz.
    Background: Skin infections account for 40% of emergency visits in pediatric dermatology. It is important to promptly recognize skin infections with potential complications and initiate treatment. However some characteristic skin findings may imitate skin infections and are often misdiagnosed. Read More

    A 5-year randomized trial on the safety and efficacy of pimecrolimus in atopic dermatitis: a critical appraisal.
    Br J Dermatol 2017 Oct 4;177(4):999-1003. Epub 2017 Sep 4.
    Center for Evidence-based Healthcare, Medizinische Fakultät Carl Gustav Carus, TU Dresden, Dresden, Germany.
    Aim: The PETITE study (Sigurgeirsson et al.) aimed to compare safety and efficacy of pimecrolimus 1% cream (PIM) and low-to-medium-potency topical corticosteroids (TCS) in children with mild-to-moderate atopic dermatitis (AD).

    Setting And Design: Participants of this 5-year drug-company sponsored multicentre, open-label, parallel-group trial were recruited between April 2004 and October 2005. Read More

    Acanthamoeba castellanii interactions with Streptococcus pneumoniae and Streptococcus pyogenes.
    Exp Parasitol 2017 Dec 17;183:128-132. Epub 2017 Aug 17.
    Department of Biological Sciences, School of Science and Technology, Sunway University, Malaysia.
    Among the genus Streptococcus, S. pyogenes and S. pneumoniae are the major causes of pharyngitis, impetigo, pneumonia and meningitis in humans. Read More

    Analysis of Post Earthquake Disease Pattern in a Camp at Gyampesal Gorkha.
    Kathmandu Univ Med J (KUMJ) 2016 Jul-Sept.;14(55):249-253
    Department of Pediatrics, Manipal College of Medical Science, Pokhara, Nepal.
    Background A major earthquake occurred in Nepal on 25th April 2015 with magnitude of 7.8 causing mass panic amongst people. Objective To analyze scenario, experience and disease pattern of Post Earthquake camp at Gyampesal, Gorkha. Read More

    Incremental Contributions of FbaA and Other Impetigo-Associated Surface Proteins to Fitness and Virulence of a Classical Group A Streptococcal Skin Strain.
    Infect Immun 2017 Nov 18;85(11). Epub 2017 Oct 18.
    Department of Microbiology and Immunology, New York Medical College, Valhalla, New York, USA
    Group A streptococci (GAS) are highly prevalent human pathogens whose primary ecological niche is the superficial epithelial layers of the throat and/or skin. Many GAS strains with a strong tendency to cause pharyngitis are distinct from strains that tend to cause impetigo; thus, genetic differences between them may confer host tissue-specific virulence. In this study, the FbaA surface protein gene was found to be present in most skin specialist strains but largely absent from a genetically related subset of pharyngitis isolates. Read More

    A Red Blood Cell Membrane-Camouflaged Nanoparticle Counteracts Streptolysin-Mediated Virulence Phenotypes of Invasive Group A.
    Front Pharmacol 2017 18;8:477. Epub 2017 Jul 18.
    Biomedical Sciences Graduate Program, University of California, San Diego, La JollaCA, United States.
    Group A(GAS), an important human-specific Gram-positive bacterial pathogen, is associated with a broad spectrum of disease, ranging from mild superficial infections such as pharyngitis and impetigo, to serious invasive infections including necrotizing fasciitis and streptococcal toxic shock syndrome. The GAS pore-forming streptolysin O (SLO) is a well characterized virulence factor produced by nearly all GAS clinical isolates. High level expression of SLO is epidemiologically linked to intercontinental dissemination of hypervirulent clonotypes and poor clinical outcomes. Read More

    The increasing relevance of biofilms in common dermatological conditions.
    J Dermatolog Treat 2018 Mar 9;29(2):202-207. Epub 2017 Aug 9.
    b Department of Dermatologic Surgery and Laser Unit, St. Thomas' Hospital , St. John's Institute of Dermatology , London , UK.
    Background: Biofilms are diverse groups of microorganisms encased in a self-produced matrix that offers protection against unfavorable conditions and antibiotics.

    Methods: We performed a literature search using the MEDLINE electronic database. Only original articles published in English were considered for review. Read More

    Community-Based Prescribing for Impetigo in Remote Australia: An Opportunity for Antimicrobial Stewardship.
    Front Public Health 2017 12;5:158. Epub 2017 Jul 12.
    Kimberley Population Health Unit, Western Australia Country Health Service (WACHS)-Kimberley, Broome, WA, Australia.
    Background: To support antibiotic prescribing for both hospital and community-based health professionals working in remote North Western Australia, a multidisciplinary Antimicrobial Stewardship (AMS) Committee was established in 2013. This Committee is usually focused on hospital-based prescribing. A troubling increase in sulfamethoxazole/trimethoprim resistance inantibiograms from 9 to 18% over 1 year prompted a shift in gaze to community prescribing. Read More

    Skin and soft tissue infections, active component, U.S. Armed Forces, 2013-2016.
    MSMR 2017 Jul;24(7):2-11
    During the 4-year surveillance period, there were 282,571 incident cases of skin and soft tissue infection (SSTI) among active component U.S. military members diagnosed in inpatient or outpatient settings, corresponding to an overall incidence of 558. Read More

    Infectious Complications of Circumcision and Their Prevention.
    Eur Urol Focus 2016 Oct 19;2(4):453-459. Epub 2016 Feb 19.
    Departments of Pediatrics and Medicine, Georgetown University School of Medicine, Washington, DC, USA. Electronic address:
    Context: A growing body of evidence supports the health benefits of circumcision, but the occurrence of infectious complications is of concern.

    Objective: To review literature presenting past data and studies of infectious complications of circumcision and their prevention.

    Evidence Acquisition: A literature search was conducted of the Cochrane Library, Embase, Turning Research into Practice, PubMed, and Medline databases from their inception through June 25, 2015. Read More

    The Epidemiology of Scabies and Impetigo in Relation to Demographic and Residential Characteristics: Baseline Findings from the Skin Health Intervention Fiji Trial.
    Am J Trop Med Hyg 2017 Sep 19;97(3):845-850. Epub 2017 Jul 19.
    Murdoch Children's Research Institute, Melbourne, Australia.
    Scabies and associated impetigo are under-recognized causes of morbidity in many developing countries. To strengthen the evidence base for scabies control we undertook a trial of mass treatment for scabies. We report on the occurrence and predictors of scabies and impetigo in participants at baseline. Read More

    Are scabies and impetigo "normalised"? A cross-sectional comparative study of hospitalised children in northern Australia assessing clinical recognition and treatment of skin infections.
    PLoS Negl Trop Dis 2017 Jul 3;11(7):e0005726. Epub 2017 Jul 3.
    Department of Infectious Diseases, Princess Margaret Hospital for Children, Perth, Western Australia.
    Background: Complications of scabies and impetigo such as glomerulonephritis and invasive bacterial infection in Australian Aboriginal children remain significant problems and the overall global burden of disease attributable to these skin infections remains high despite the availability of effective treatment. We hypothesised that one factor contributing to this high burden is that skin infection is under-recognised and hence under-treated, in settings where prevalence is high.

    Methods: We conducted a prospective, cross-sectional study to assess the burden of scabies, impetigo, tinea and pediculosis in children admitted to two regional Australian hospitals from October 2015 to January 2016. Read More

    A Screening Study on Dermatoses in Pregnancy.
    J Clin Diagn Res 2017 May 1;11(5):WC01-WC05. Epub 2017 May 1.
    Associate Professor, Department of Dermatology, Venereology and Leprosy, Villupuram Medical College, Villupuram, Tamil Nadu, India.
    Introduction: Pregnancy produces many cutaneous changes, some of which are specifically related to pregnancy (dermatoses of pregnancy), some are modifiable by pregnancy and others that are common are named physiologic. These physiologic skin changes, usually do not impair the health of the mother or the fetus but some of them can be cosmetically significant and of importance to the dermatologist.

    Aim: The present study was undertaken to find out the prevalence of the physiological and pathological skin changes in pregnancy, and to correlate the prevalence of the major cutaneous changes and diseases in relation to different trimesters of pregnancy and with gravidity. Read More

    Emergence of a Staphylococcus aureus Clone Resistant to Mupirocin and Fusidic Acid Carrying Exotoxin Genes and Causing Mainly Skin Infections.
    J Clin Microbiol 2017 Aug 7;55(8):2529-2537. Epub 2017 Jun 7.
    Second Department of Pediatrics, National and Kapodistrian University of Athens, School of Medicine, P. & A. Kyriakou Children's Hospital, Athens, Greece.
    Skin and soft tissue infections (SSTIs) caused by mupirocin-resistantstrains have recently increased in number in our settings. We sought to evaluate the characteristics of these cases over a 43-month period. Data for all community-acquired staphylococcal infections caused by mupirocin-resistant strains were retrospectively reviewed. Read More

    Current and Emerging Topical Antibacterials and Antiseptics: Agents, Action, and Resistance Patterns.
    Clin Microbiol Rev 2017 Jul;30(3):827-860
    Microbiological Diagnostic Unit Public Health Laboratory, Department of Microbiology & Immunology, The University of Melbourne at The Doherty Institute for Infection and Immunity, Melbourne, Victoria, Australia.
    Bacterial skin infections represent some of the most common infectious diseases globally. Prevention and treatment of skin infections can involve application of a topical antimicrobial, which may be an antibiotic (such as mupirocin or fusidic acid) or an antiseptic (such as chlorhexidine or alcohol). However, there is limited evidence to support the widespread prophylactic or therapeutic use of topical agents. Read More

    Two highly divergent lineages of exfoliative toxin B-encoding plasmids revealed in impetigo strains of Staphylococcus aureus.
    Int J Med Microbiol 2017 Sep 29;307(6):291-296. Epub 2017 May 29.
    Department of Experimental Biology, Faculty of Science, Masaryk University, Kotlářská 2, 611 37 Brno, Czech Republic.
    Exfoliative toxin B (ETB) encoded by some large plasmids plays a crucial role in epidermolytic diseases caused by Staphylococcus aureus. We have found as yet unknown types of etb gene-positive plasmids isolated from a set of impetigo strains implicated in outbreaks of pemphigus neonatorum in Czech maternity hospitals. Plasmids from the strains of clonal complex CC121 were related to archetypal plasmid pETB. Read More

    Prevalence of skin infections caused by Panton-Valentine leukocidin-positive methicillin-resistant Staphylococcus aureus in Japan, particularly in Ishigaki, Okinawa.
    J Infect Chemother 2017 Nov 25;23(11):800-803. Epub 2017 May 25.
    Department of Microbiology, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, 1432-1 Horinouchi, Hachioji, Tokyo 192-0392, Japan. Electronic address:
    The prevalence of Panton-Valentine leukocidin gene (pvl)-positive community-acquired methicillin-resistant Staphylococcus aureus USA300 clone, which is designated as the ST8-staphylococcal cassette chromosome (SCC) mec type IV (ST8-IV) lineage, is a major public health concern worldwide. Thus, to elucidate the prevalence and characteristics of pvl-positive community-onset MRSA in Japan, we conducted a molecular epidemiological analysis for 854 S. aureus isolates obtained from outpatients with skin infections during 2013 and 2014. Read More

    Differences in SpeB protease activity among group A streptococci associated with superficial, invasive, and autoimmune disease.
    PLoS One 2017 17;12(5):e0177784. Epub 2017 May 17.
    Department of Microbiology and Immunology, New York Medical College, Valhalla, New York, United States of America.
    The secreted cysteine proteinase SpeB is an important virulence factor of group A streptococci (GAS), whereby SpeB activity varies widely among strains. To establish the degree to which SpeB activity correlates with disease, GAS organisms were recovered from patients with pharyngitis, impetigo, invasive disease or acute rheumatic fever (ARF), and selected for analysis using rigorous sampling criteria; >300 GAS isolates were tested for SpeB activity by casein digestion assays, and each GAS isolate was scored as a SpeB-producer or non-producer. Highly significant statistical differences (p < 0. Read More

    Transition Metal Homeostasis in Streptococcus pyogenes and Streptococcus pneumoniae.
    Adv Microb Physiol 2017 20;70:123-191. Epub 2017 Feb 20.
    School of Chemistry and Molecular Biosciences and Australian Infectious Diseases Research Centre, The University of Queensland, Brisbane, QLD, Australia. Electronic address:
    Trace metals such as Fe, Mn, Zn and Cu are essential for various biological functions including proper innate immune function. The host immune system has complicated and coordinated mechanisms in place to either starve and/or overload invading pathogens with various metals to combat the infection. Here, we discuss the roles of Fe, Mn and Zn in terms of nutritional immunity, and also the roles of Cu and Zn in metal overload in relation to the physiology and pathogenesis of two human streptococcal species, Streptococcus pneumoniae and Streptococcus pyogenes. Read More

    Whole genome sequencing of group A: development and evaluation of an automated pipeline forgene typing.
    PeerJ 2017 27;5:e3226. Epub 2017 Apr 27.
    Respiratory and Vaccine Preventable Bacterial Reference Unit, Public Health England, London, United Kingdom.
    group A(GAS) is the most common cause of bacterial throat infections, and can cause mild to severe skin and soft tissue infections, including impetigo, erysipelas, necrotizing fasciitis, as well as systemic and fatal infections including septicaemia and meningitis. Estimated annual incidence for invasive group A streptococcal infection (iGAS) in industrialised countries is approximately three per 100,000 per year. Typing is currently used in England and Wales to monitor bacterial strains ofcausing invasive infections and those isolated from patients and healthcare/care workers in cluster and outbreak situations. Read More

    Advances in pharmacotherapeutic management of common skin diseases in neonates and infants.
    Expert Opin Pharmacother 2017 May 21;18(7):717-725. Epub 2017 Apr 21.
    a Dermatology, Department of Experimental, Diagnostic and Specialty Medicine , Sant'Orsola-Malpighi Hospital, University of Bologna , Bologna , Italy.
    Introduction: neonatal and infantile skin diseases are frequently encountered in the clinical practice and represent worldwide a socioeconomic issue. They encompass a wide range of acquired or congenital conditions, including infections, vascular lesions and inflammatory diseases and can present with different degrees of severity, leading in some cases to dramatic complications. Areas covered: In this paper we report the most recent evidences on the management of some common skin diseases in neonates and infants. Read More

    [Evaluation of practices in the management of scabies in children].
    Ann Dermatol Venereol 2017 May 10;144(5):341-348. Epub 2017 Apr 10.
    UMR 911, Inserm CRO2, « centre de recherche en oncologie biologique et oncopharmacologie », service de dermatologie, hôpital Timone, Aix-Marseille université, Assistance publique des Hôpitaux de Marseille, 13005 Marseille, France.
    Background: Scabies has been on the rise in France in recent years and has posed therapeutic problems, mainly due to the withdrawal of benzyl benzoate. The objective of this study was to describe prescribing practices for scabies in children.

    Methods: A national survey was conducted by means of a standardized questionnaire covering various clinical situations of scabies and the drugs used preferentially according to age, which was sent out between December 2014 and March 2015 to members of the clinical research group of the French Society of Paediatric Dermatology. Read More

    Skin diseases of the vulva: Infectious diseases.
    J Obstet Gynaecol 2017 Oct 11;37(7):840-848. Epub 2017 Apr 11.
    a Department of Dermatology , Bispebjerg Hospital , Copenhagen , Denmark.
    A multitude of infectious diseases of viral (genital herpes, herpes zoster, genital warts and molluscum contagiosum), bacterial (syphilis, chancroid, lymphogranuloma venereum, donovanosis, erysipelas, cellulitis and necrotising fasciitis, folliculitis, impetigo, bartholin gland abscess, trichomycosis and erythrasma), fungal (candidiasis and dermatophytosis) and parasitic (pediculosis pubis) origin may affect the vulvar area. Herein, we review the infections and their skin manifestations in the vulvar area. Read More

    [An rare complication of scarlet fever : invasive group A streptococcal infection with streptococcal toxic shock syndrome].
    Rev Med Liege 2017 Mar;72(3):132-137
    Service de Pédiatrie, CHU de Liège, Site NDB, Liège, Belgique.
    Invasive Group A Streptococcus infections and streptococcal toxic shock syndrome are rare complications of common diseases in children such as scarlet fever or impetigo. These invasive diseases are particulary challenging because of their rapid progression and the lack of predisposing factors in most cases. Prompt diagnosis and treatment are mandatory to reduce the mortality associated with these severe diseases. Read More

    Immunization with a streptococcal multiple-epitope recombinant protein protects mice against invasive group A streptococcal infection.
    PLoS One 2017 29;12(3):e0174464. Epub 2017 Mar 29.
    Department of Biological Science and Technology, College of Medicine, I-Shou University, Kaohsiung, Taiwan.
    Streptococcus pyogenes (group A Streptococcus; GAS) causes clinical diseases, including pharyngitis, scarlet fever, impetigo, necrotizing fasciitis and streptococcal toxic shock syndrome. A number of group A streptococcus vaccine candidates have been developed, but only one 26-valent recombinant M protein vaccine has entered clinical trials. Differing from the design of a 26-valent recombinant M protein vaccine, we provide here a vaccination using the polyvalence epitope recombinant FSBM protein (rFSBM), which contains four different epitopes, including the fibronectin-binding repeats domain of streptococcal fibronectin binding protein Sfb1, the C-terminal immunogenic segment of streptolysin S, the C3-binding motif of streptococcal pyrogenic exotoxin B, and the C-terminal conserved segment of M protein. Read More

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