Expert Rev Neurother 2021 09 26;21(9):1051-1058. Epub 2021 Aug 26.
Director Of Rehabilitation Neuropsychology; Director, SRN Disorders Of Consciousness Program; Project Director, Spaulding-Harvard TBI Model System, Spaulding Rehabilitation Hospital, Charlestown, MA; And Consulting Neuropsychologist, Department Of Psychiatry, Massachusetts General Hospital, Boston, MA; And Professor, Department Of Physical Medicine And Rehabilitation, Harvard Medical School, Boston, MA, USA.
Objective: To determine minimally clinically important differences (MCIDs) for Disability Rating Scale (DRS), Fugl-Meyer Upper Extremity Subscale (FM-UE), Fugl-Meyer Lower Extremity Subscale (FM-LE), and Fugl-Meyer Motor Scale (FMMS) in patients with chronic motor deficits secondary to traumatic brain injury (TBI).
Methods: Retrospective analysis from the 1-year, double-blind, randomized, surgical sham-controlled, Phase 2 STEMTRA trial (NCT02416492), in which patients with chronic motor deficits secondary to TBI (N = 61) underwent intracerebral stereotactic implantation of modified bone marrow-derived mesenchymal stromal (SB623) cells. MCIDs for DRS, FM-UE, FM-LE, and FMMS were triangulated with distribution-based, anchor-based, and Delphi panel estimates. Read More