3,301 results match your criteria Immunopharmacology and Immunotoxicology[Journal]


Inhalation of the prodrug PI3K inhibitor CL27c improves lung function in asthma and fibrosis.

Nat Commun 2018 Dec 12;9(1):5232. Epub 2018 Dec 12.

Department of Molecular Biotechnology and Health Sciences, Molecular Biotechnology Center, University of Torino, Via Nizza 52, 10126, Torino, Italy.

PI3K activation plays a central role in the development of pulmonary inflammation and tissue remodeling. PI3K inhibitors may thus offer an improved therapeutic opportunity to treat non-resolving lung inflammation but their action is limited by unwanted on-target systemic toxicity. Here we present CL27c, a prodrug pan-PI3K inhibitor designed for local therapy, and investigate whether inhaled CL27c is effective in asthma and pulmonary fibrosis. Read More

View Article
December 2018

Ginsenoside Rg1 protects against H2O2‑induced neuronal damage due to inhibition of the NLRP1 inflammasome signalling pathway in hippocampal neurons in vitro.

Int J Mol Med 2018 Nov 30. Epub 2018 Nov 30.

Department of Pharmacology, Key Laboratory of Anti‑inflammatory and Immunopharmacology, Ministry of Education, Anhui Medical University, Hefei, Anhui 230032, P.R. China.

Oxidative stress and neuroinflammation are important in the pathogenesis of ageing and age‑related neurodegenerative diseases, including Alzheimer's disease. NADPH oxidase 2 (NOX2) is a major source of reactive oxygen species (ROS) in the brain. The nucleotide‑binding oligomerisation domain (NOD)‑like receptor protein 1 (NLRP1) inflammasome is responsible for the formation of pro‑inflammatory molecules in neurons. Read More

View Article
November 2018
1 Read

Corrigendum to "Caspase-independent cell death by allicin in human epithelial carcinoma cells: involvement of PKA."[Canc. Lett. (2005) 224 (1) 123-32].

Cancer Lett 2018 Dec 5. Epub 2018 Dec 5.

Division of Immunopharmacology, College of Pharmacy, Sungkyunkwan University, Suwon, Kyunggi-do, 440-746, South Korea. Electronic address:

View Article
December 2018

New Insights in Purinergic Therapy: Novel Antagonists for Uridine 5'-Triphosphate-Activated P2Y Receptors from Brazilian Flora.

J Med Food 2018 Dec 8. Epub 2018 Dec 8.

1 Laboratory of Cellular Communication, Oswaldo Cruz Institute , Oswaldo Cruz Foundation, Rio de Janeiro, Brazil .

P2Y2 and P2Y4 receptors are physiologically activated by uridine 5'-triphosphate (UTP) and are widely expressed in many cell types in humans. P2Y2 plays an important role in inflammation and proliferation of tumor cells, which could be attenuated with the use of antagonists. However, little is known about the physiological functions related to P2Y4, due to the lack of selective ligands for these receptors. Read More

View Article
December 2018

Chondroitin sulfate inhibits secretion of TNF and CXCL8 from human mast cells stimulated by IL-33.

Biofactors 2018 Dec 6. Epub 2018 Dec 6.

Laboratory of Molecular Immunopharmacology and Drug Discovery, Department of Immunology, Tufts University School of Medicine, Boston, MA, USA.

Glycosaminoglycans (GAGs) are linear, highly negatively charged carbohydrate chains present in connective tissues. Chondroitin sulfate (CS) and heparin (Hep) are also found in the numerous secretory granules of mast cells (MC), tissue immune cells involved in allergic and inflammatory reactions. CS and Hep may inhibit secretion of histamine from rat connective tissue MC, but their effect on human MC remains unknown. Read More

View Article
December 2018
1 Read

High plasma resistin associates with severe acute kidney injury in Puumala hantavirus infection.

PLoS One 2018 5;13(12):e0208017. Epub 2018 Dec 5.

Tampere University Hospital, Department of Internal Medicine, Tampere, Finland.

Background: Puumala hantavirus (PUUV) infected patients typically suffer from acute kidney injury (AKI). Adipokines have inflammation modulating functions in acute diseases including AKI. We examined plasma levels of three adipokines (resistin, leptin, and adiponectin) in acute PUUV infection and their associations with disease severity. Read More

View Article
December 2018
4 Reads

Total flavonoids from Semen Cuscutae target MMP9 and promote invasion of EVT cells via Notch/AKT/MAPK signaling pathways.

Sci Rep 2018 Nov 26;8(1):17342. Epub 2018 Nov 26.

Department of Gynecology, No. 1 Affiliated Hospital to Guangzhou University of Chinese Medicine, Guangzhou, China.

Miscarriage is a common condition during pregnancy and its mechanisms remain largely unknown. Extravillous trophoblast (EVT) cell invasion is required to maintain normal pregnancy and its malfunction has been proposed as a major cause for miscarriage. Homeostasis of matrix metalloproteinase 9 (MMP9) is a key to regulate EVT cell invasion. Read More

View Article
November 2018
1 Read

Wild-type LRRK2 as a new potential therapeutic target in idiopathic Parkinson's disease.

Mov Disord 2018 Nov 19. Epub 2018 Nov 19.

Neurology division, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.

View Article
November 2018

Tetramethoxyluteolin for the treatment of neurodegenerative diseases.

Curr Top Med Chem 2018 Nov 19. Epub 2018 Nov 19.

Molecular Immunopharmacology and Drug Discovery Laboratory, Department of Immunology, Tufts University School of Medicine, Boston, MA. United States.

Background Most neurodegenerative and other brain disorders, especially Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) and autism spectrum disorder (ASD) continue to elude objective biomarkers and effective treatments. Increasing evidence indicates that such diseases involve focal inflammation of the brain. Objective To review the role of cytokine-neuropeptide interactions in the pathogenesis of inflammation of the brain and the beneficial role of natural flavonoids. Read More

View Article
November 2018
4 Reads

Compound Astragalus and Salvia miltiorrhiza extract inhibits hepatocellular carcinoma progression via miR-145/miR-21 mediated Smad3 phosphorylation.

J Ethnopharmacol 2018 Nov 6;231:98-112. Epub 2018 Nov 6.

Department of Pharmacology, Anhui Medical University, Key Laboratory of Anti-inflammatory and Immunopharmacology, Ministry of Education, Hefei 230032, China. Electronic address:

Ethnopharmacological Relevance: Compound Astragalus and Salvia miltiorrhiza extract (CASE), containing astragalosides, astragalus polysaccharide extracted from Astragalus membranaceus (Fisch.) Bge. and salvianolic acids from Salvia miltiorhiza Bge. Read More

View Article
November 2018
3 Reads

Vaccination reduces fentanyl distribution to the brain and fentanyl-induced toxicity in mice and rats: a potential role for a prophylactic vaccine against fentanyl-induced overdose.

J Pharmacol Exp Ther 2018 Nov 8. Epub 2018 Nov 8.

Hennepin Healthcare Research Institute.

Fentanyl is an extremely potent synthetic opioid that has been increasingly used to adulterate heroin, cocaine and counterfeit prescription pills leading to an increase in opioid-induced fatal overdoses in the US, Canada, and Europe. A vaccine targeting fentanyl could offer protection against fatal overdoses in both recreational drug users and others in professions at risk of accidental exposure. This study focuses on the development of a vaccine consisting of a fentanyl hapten (F) conjugated to keyhole limpet hemocyanin (KLH) carrier protein or to GMP-grade subunit KLH (sKLH). Read More

View Article
November 2018
3 Reads

Brain volume loss and no evidence of disease activity over 3 years in multiple sclerosis patients under interferon beta 1a subcutaneous treatment.

J Clin Neurosci 2018 Nov 3. Epub 2018 Nov 3.

Multiple Sclerosis Center of Buenos Aires, Hospital Italiano de Buenos Aires, Argentina.

The objective of our study was to evaluate the relationship of percentage of annualized brain volume loss (aBVL) and no evidence of disease activity (NEDA) in multiple sclerosis (MS) patients under interferon beta 1-a subcutaneous treatment (IFN-beta) during 3 years of follow up. Relapsing remitting MS (RRMS) patients, with less than three years from disease onset, expanded disability status scale (EDSS) ≤3 and in which IFN beta 1-a 44 mcg was indicated, were included. Demographic, clinical and structural parameters from the magnetic resonance (MR) during the 3 years of follow up were analyzed and compared between patients with and without NEDA (defined as the absence of: (a) three-month confirmed disability progression defined as an increase in EDSS score of 1. Read More

View Article
November 2018
5 Reads

Protective effects of Astragaloside IV on endoplasmic reticulum stress-induced renal tubular epithelial cells apoptosis in type 2 diabetic nephropathy rats.

Biomed Pharmacother 2019 Jan 2;109:84-92. Epub 2018 Nov 2.

Key Laboratory of Anti-Inflammatory and Immunopharmacology, Ministry of Education, Department of Pharmacology, Anhui Medical University, Hefei 230032, Anhui, China; Anqing Medical and Pharmaceutical College, Anqing 246052, Anhui, China. Electronic address:

Diabetic nephropathy (DN) has become the leading cause of end-stage renal disease (ESRD) worldwide. Renal tubular injury plays an important role in the development and progression of DN. And apoptosis of renal tubular epithelial cells (RTEC) contribute to the loss of renal function, increased levels of serum creatinine (SCr), blood urea nitrogen (BUN), urine total protein to urine creatinine and microalbuminuria and reduction of creatinine clear rate (CCr). Read More

View Article
January 2019
4 Reads

Effect of IL-33 on de novo synthesized mediators from human mast cells.

J Allergy Clin Immunol 2018 Oct 31. Epub 2018 Oct 31.

Department of Pharmacology, Boston University School of Medicine, Boston, Mass.

View Article
October 2018

Mitochondrial dysfunction in affected skin and increased mitochondrial DNA in serum from patients with psoriasis.

Exp Dermatol 2018 Nov 3. Epub 2018 Nov 3.

Molecular Immunopharmacology and Drug Discovery Laboratory, Department of Immunology, Tufts University School of Medicine, Boston, MA, USA.

Psoriasis is characterized by keratinocyte proliferation and chronic inflammation, but the pathogenesis is still unclear. Dysregulated mitochondria (mt) could lead to reduced apoptosis and extracellular secretion of mtDNA, acting as "innate pathogen" triggering inflammation. Serum was obtained from healthy volunteers and psoriatic patients. Read More

View Article
November 2018
7 Reads

Antioxidative, inflammatory and immune responses in hydrogen peroxide-induced liver injury of tilapia (GIFT, Oreochromis niloticus).

Fish Shellfish Immunol 2018 Oct 31;84:894-905. Epub 2018 Oct 31.

Key Laboratory of Freshwater Fisheries and Germplasm Resources Utilization, Ministry of Agriculture and Rural Affairs, Freshwater Fisheries Research Center, Chinese Academy of Fishery Sciences, Wuxi, 214081, China; International Joint Research Laboratory for Fish Immunopharmacology, Freshwater Fisheries Research Center, Chinese Academy of Fishery Sciences, Wuxi, 214081, China. Electronic address:

Oxidative stress has been implicated in the pathogenesis of many liver diseases in fish, but the molecular mechanism is still obscure. Here, we used hydrogen peroxide (HO) as a reactive oxygen species (ROS) to induce liver injury and assess underlying molecular mechanism linking oxidative stress and liver injury in fish. Tilapia were injected with various concentrations of HO (0, 40, 120, 200, 300 and 400 mM) for 72 h. Read More

View Article
October 2018
2 Reads
2.670 Impact Factor

MKP-1 Promotes Anti-inflammatory M(IL-4/IL-13) Macrophage Phenotype and Mediates the Anti-inflammatory Effects of Glucocorticoids.

Basic Clin Pharmacol Toxicol 2018 Nov 2. Epub 2018 Nov 2.

The Immunopharmacology Research Group Faculty of Medicine and Life Sciences, University of Tampere and Tampere University Hospital, Tampere, Finland.

Macrophage polarization refers to the ability of these cells to adopt different functional phenotypes according to their environment. Mitogen-activated protein kinase phosphatase-1 (MKP-1) is known to regulate the classical lipopolysaccharide (LPS) -induced pro-inflammatory macrophage activation and the inflammatory response. Here, we investigated the effects of MKP-1 on the anti-inflammatory and healing-promoting macrophage phenotype induced by cytokines IL-4 and IL-13 and examined the potential mediator role of MKP-1 in glucocorticoid effects on the two macrophage phenotypes. Read More

View Article
November 2018
8 Reads

Indirubin derivatives are potent and selective anti-Trypanosoma cruzi agents.

Virulence 2018 ;9(1):1658-1668

b Laboratory of Tissue Engineering and Immunopharmacology , Instituto Gonçalo Moniz, Fundação Oswaldo Cruz (FIOCRUZ) , Salvador , BA , Brazil.

Current treatment for combatting Chagas disease, a life-threatening illness caused by the kinetoplastid protozoan parasite Trypanosoma cruzi is inadequate, and thus the discovery of new antiparasitic compounds is of prime importance. Previous studies identified the indirubins, a class of ATP kinase inhibitors, as potent growth inhibitors of the related kinetoplastid Leishmania. Herein, we evaluated the inhibitory activity of a series of 69 indirubin analogues screened against T. Read More

View Article
January 2018
1 Read

Phosphodiesterase-4 Inhibitors for the Treatment of Inflammatory Diseases.

Front Pharmacol 2018 17;9:1048. Epub 2018 Oct 17.

Laboratory of Anti-inflammation, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China.

Phosphodiesterase-4 (PDE4), mainly present in immune cells, epithelial cells, and brain cells, manifests as an intracellular non-receptor enzyme that modulates inflammation and epithelial integrity. Inhibition of PDE4 is predicted to have diverse effects via the elevation of the level of cyclic adenosine monophosphate (cAMP) and the subsequent regulation of a wide array of genes and proteins. It has been identified that PDE4 is a promising therapeutic target for the treatment of diverse pulmonary, dermatological, and severe neurological diseases. Read More

View Article
October 2018
2 Reads

Immunopharmacology of Post-Myocardial Infarction and Heart Failure Medications.

J Clin Med 2018 Oct 31;7(11). Epub 2018 Oct 31.

National Heart and Lung Institute, Imperial College London, London W12 0NN, UK.

The immune system responds to acute tissue damage after myocardial infarction (MI) and orchestrates healing and recovery of the heart. However, excessive inflammation may lead to additional tissue damage and fibrosis and exacerbate subsequent functional impairment, leading to heart failure. The appreciation of the immune system as a crucial factor after MI has led to a surge of clinical trials investigating the potential benefits of immunomodulatory agents previously used in hyper-inflammatory conditions, such as autoimmune disease. Read More

View Article
October 2018
2 Reads

Ginger (Zingiber officinale Rosc.) Ameliorated Metabolic and Inflammatory Dysfunction Induced by High-Refined Carbohydrate-Containing Diet in Mice.

J Med Food 2018 Oct 26. Epub 2018 Oct 26.

3 Department of Nutrition, Nursing School , Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, Brazil .

This study aimed to evaluate the effects and the mechanisms of ginger extract intake in the adiposity gain, metabolic and inflammatory disturbances induced by a high-refined carbohydrate (HC) diet in mice. Ginger extract at doses of 200, 600, and 1800 mg/kg was supplemented in the daily food of obese Balb/c mice during an 8-week experiment. Our findings indicate that consumption of high doses of ginger extracts prevents the increase of adiposity induced by HC diet, improves lipid profile, and promotes decrease of inflammatory markers in mice. Read More

View Article
October 2018
5 Reads

Virgin coconut oil is effective to treat metabolic and inflammatory dysfunction induced by high refined carbohydrate-containing diet in mice.

J Nutr Biochem 2018 Sep 1;63:117-128. Epub 2018 Sep 1.

Department of Nutrition, Nursing School, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil. Electronic address:

The global rise in obesity rates is alarming since this condition is associated with chronic low-grade inflammation and secondary comorbidities as glucose intolerance, cardiovascular disease and liver damage. Therefore, a lot of dietary approaches are proposed to prevent and to treat obesity and its associated disorders. Virgin coconut oil (VCO) is well known as a functional food due to its significant amounts of medium-chain triglycerides. Read More

View Article
September 2018
4 Reads

Therapeutic treatment of Zika virus infection using a brain-penetrating antiviral peptide.

Nat Mater 2018 Nov 22;17(11):971-977. Epub 2018 Oct 22.

School of Materials Science and Engineering, Nanyang Technological University, Singapore, Singapore.

Zika virus is a mosquito-borne virus that is associated with neurodegenerative diseases, including Guillain-Barré syndrome and congenital Zika syndrome. As Zika virus targets the nervous system, there is an urgent need to develop therapeutic strategies that inhibit Zika virus infection in the brain. Here, we have engineered a brain-penetrating peptide that works against Zika virus and other mosquito-borne viruses. Read More

View Article
November 2018
28 Reads

Corrigendum to "Fisetin induces Sirt1 expression while inhibiting early adipogenesis in 3T3-L1 cells" [Biochem. Biophys. Res. Commun. 467 (4) (2015) 638-644].

Biochem Biophys Res Commun 2018 Nov 16;506(1):306. Epub 2018 Oct 16.

Department of Molecular Cell Biology, Samsung Biomedical Research Institute, Sungkyunkwan University School of Medicine, Suwon, Gyeonggi-do, 16419, Republic of Korea; Department of Health Sciences and Technology, Samsung Advanced Institute for Health Sciences and Technology, Samsung Medical Center, Sungkyunkwan University, Seoul, 06351, Republic of Korea. Electronic address:

View Article
November 2018

Decreases in TGF-β1 and PDGF levels are associated with echocardiographic changes during adjuvant radiotherapy for breast cancer.

Radiat Oncol 2018 Oct 19;13(1):201. Epub 2018 Oct 19.

Faculty of Medicine and Life Sciences, University of Tampere, PO Box 100, 33014, Tampere, Finland.

Background: Radiation-induced heart disease is mainly caused by activation of the fibrotic process. Transforming growth factor-beta 1 (TGF-β1) and platelet-derived growth factor (PDGF) are pro-fibrotic mediators. The aim of our study was to evaluate the behavior of TGF-β1 and PDGF during adjuvant radiotherapy (RT) for breast cancer and the association of these cytokines with echocardiographic changes. Read More

View Article
October 2018

Antioxidative, anti-inflammatory and hepatoprotective effects of resveratrol on oxidative stress-induced liver damage in tilapia (Oreochromis niloticus).

Comp Biochem Physiol C Toxicol Pharmacol 2019 Jan 15;215:56-66. Epub 2018 Oct 15.

Wuxi Fisheries College, Nanjing Agricultural University, Wuxi 214081, China; Key Laboratory of Freshwater Fisheries and Germplasm Resources Utilization, Ministry of Agriculture and Rural Affairs, Freshwater Fisheries Research Center, Chinese Academy of Fishery Sciences, Wuxi 214081, China; International Joint Research Laboratory for Fish Immunopharmacology, Freshwater Fisheries Research Center, Chinese Academy of Fishery Sciences, Wuxi 214081, China. Electronic address:

Resveratrol, a dietary polyphenol, has been shown to exert antioxidation, hepatoprotection, anti-inflammation and immunostimulation. However, the effects and underlying mechanism of resveratrol on liver injury in fish are still unclear. In the present study, we investigated the potential protective effects and mechanism of resveratrol on oxidative stress-induced liver damage in tilapia. Read More

View Article
January 2019
9 Reads
2.300 Impact Factor

A new guide to immunopharmacology.

Nat Rev Immunol 2018 Dec;18(12):729

Deanery of Biomedical Sciences, University of Edinburgh, Edinburgh, UK.

View Article
December 2018

Protection against Gut Inflammation and Sepsis in Mice by the Autodigested Product of the Lingzhi Medicinal Mushroom, Ganoderma lingzhi (Agaricomycetes).

Int J Med Mushrooms 2018 ;20(9):809-823

Laboratory for Immunopharmacology of Microbial Products, Tokyo University of Pharmacy and Life Science, Tokyo, Japan.

Ganoderma lingzhi (reishi) (GL) is a widely used medicinal mushroom in the treatment of several diseases, including metabolic syndrome and cancer. We recently performed autodigestion of GL and found enhanced release of hypotensive peptides and immunomodulating beta-1,3-glucan. In the present study, we examined the protective effects of G. Read More

View Article
January 2018
1 Read

Effect of electroconvulsive therapy on brain-derived neurotrophic factor levels in patients with major depressive disorder.

Brain Behav 2018 Nov 1;8(11):e01101. Epub 2018 Oct 1.

Department of Psychiatry, Tampere University Hospital, Tampere, Finland.

Objectives: Brain-derived neurotrophic factor (BDNF) has been associated with depression and its treatment response. The aim of the present study was to explore the effect of electroconvulsive therapy (ECT) on serum and plasma BDNF levels and change of Montgomery-Asberg Depression Rating Scale (MADRS) and their associations in patients with major depressive disorder (MDD).

Methods: The study included thirty patients suffering from MDD. Read More

View Article
November 2018

Astragalosides IV protected the renal tubular epithelial cells from free fatty acids-induced injury by reducing oxidative stress and apoptosis.

Biomed Pharmacother 2018 Dec 21;108:679-686. Epub 2018 Sep 21.

Key Laboratory of Anti-Inflammatory and Immunopharmacology, Ministry of Education, Department of Pharmacology, Anhui Medical University, Hefei 230032, Anhui, China; Anqing Medical and Pharmaceutical College, Anqing 246052, Anhui, China. Electronic address:

Renal tubular injury is associated with the development of diabetic nephropathy (DN) and the end-stage renal disease (ESRD). Free fatty acids (FFAs)-associated lipotoxicity contributes to injury of proximal renal tubular epithelial (HK-2) cells in diabetes. Palmitic acid (PA) which is the most abundant saturated fatty acid in FFAs is closely associated with the gradual decline of renal function. Read More

View Article
December 2018
2 Reads

The ATP Transporter VNUT Mediates Induction of Dectin-1-Triggered Candida Nociception.

iScience 2018 Aug 15;6:306-318. Epub 2018 Aug 15.

Thermal Biology group, Exploratory Research Center on Life and Living Systems National Institutes of Natural Sciences, Okazaki Aichi 444-8787, Japan; Division of Cell Signaling, National Institute for Physiological Sciences, National Institutes of Natural Sciences, Okazaki, Aichi 444-8787, Japan; Department of Physiological Sciences, the Graduate University for Advanced Studies, Aichi 444-8787, Japan; Institute for Environmental and Gender Specific Medicine, Juntendo University, 2-1-1 Tomioka, Urayasu, Chiba 279-0021, Japan. Electronic address:

Candida albicans infection can cause skin, vulvar, or oral pain. Despite the obvious algesic activity of C. albicans, the molecular mechanisms of fungal nociception remain largely unknown. Read More

View Article
August 2018
5 Reads

Substance P and IL-33 administered together stimulate a marked secretion of IL-1β from human mast cells, inhibited by methoxyluteolin.

Proc Natl Acad Sci U S A 2018 10 19;115(40):E9381-E9390. Epub 2018 Sep 19.

Laboratory of Molecular Immunopharmacology and Drug Discovery, Department of Immunology, Tufts University School of Medicine, Boston, MA 02111;

Mast cells are critical for allergic and inflammatory responses in which the peptide substance P (SP) and the cytokine IL-33 are involved. SP (0.01-1 μM) administered together with IL-33 (30 ng/mL) to human cultured LAD2 mast cells stimulates a marked increase ( < 0. Read More

View Article
October 2018
1 Read

Light-enhanced VEGF/rGel: A tumor targeted modality with vascular and immune-mediated efficacy.

J Control Release 2018 Oct 11;288:161-172. Epub 2018 Sep 11.

Department of Radiation Biology, Institute for Cancer Research, Norwegian Radium Hospital, Oslo University hospital, Norway.

Interactions between stromal cells and tumor cells pay a major role in cancer growth and progression. This is reflected in the composition of anticancer drugs which includes compounds directed towards the immune system and tumor-vasculature in addition to drugs aimed at the cancer cells themselves. Drug-based treatment regimens are currently designed to include compounds targeting the tumor stroma in addition to the cancer cells. Read More

View Article
October 2018
6 Reads

Effects of Polyphenols on Thermogenesis and Mitochondrial Biogenesis.

Int J Mol Sci 2018 Sep 13;19(9). Epub 2018 Sep 13.

Laboratory of Immunopharmacology and Molecular Biology, Sao Francisco University Medical School, Av Sao Francisco de Assis, 218, Braganca Paulista, São Paulo 12916-900, Brazil.

Obesity is a health problem worldwide, and energy imbalance has been pointed out as one of the main factors responsible for its development. As mitochondria are a key element in energy homeostasis, the development of obesity has been strongly associated with mitochondrial imbalance. Polyphenols are the largest group of phytochemicals, widely distributed in the plant kingdom, abundant in fruits and vegetables, and have been classically described as antioxidants owing to their well-established ability to eliminate free radicals and reactive oxygen species (ROS). Read More

View Article
September 2018
1 Read
2.860 Impact Factor

NLRP3 inflammasome in colitis and colitis-associated colorectal cancer.

Mamm Genome 2018 Sep 11. Epub 2018 Sep 11.

Menzies Institute for Medical Research, University of Tasmania, MS2, 17 Liverpool St, Hobart, TAS, 7000, Australia.

A low level of inflammation is an integral part of the balance between the immune system and the microbiota in the high antigen environment of the gastrointestinal tract and maintains homeostasis. A failure of this balance can lead to chronic intestinal inflammation and increase the chances to develop colorectal cancer significantly. The underlying mechanisms that link inflammation and carcinogenesis are not clear but the molecular platforms of the inflammasomes have been implicated. Read More

View Article
September 2018
3 Reads

GYY4137 Promotes Mice Feeding Behavior via Arcuate Nucleus Sulfur-Sulfhydrylation and AMPK Activation.

Front Pharmacol 2018 21;9:966. Epub 2018 Aug 21.

Department of Pharmacology, School of Basic Medical Sciences, Key Laboratory of Anti-inflammatory and Immunopharmacology, Anhui Medical University, Hefei, China.

Hydrogen sulfide (HS) is an endogenous gaseous molecule and plays important biological and neurochemical roles in many processes such as the neural activity and immunity. The arcuate nucleus (ARC) of hypothalamus is a control center for appetite and energy metabolism. AMPK is a gage kinase in the monitoring of energy status and regulation of energy metabolism, and it can be activated by HS via CaMKKβ/AMPK pathway. Read More

View Article
August 2018
5 Reads

Tyrosine kinase receptor TIE-1 mediates platinum resistance by promoting nucleotide excision repair in ovarian cancer.

Sci Rep 2018 Sep 4;8(1):13207. Epub 2018 Sep 4.

Department of Obstetrics and Gynecology, Tohoku University Graduate School of Medicine, Sendai, Japan.

Platinum resistance is one of the most challenging problems in ovarian cancer treatment. High-throughput functional siRNA screening identified tyrosine kinase with immunoglobulin-like and EGF-like domains 1 (TIE-1) as a gene that confers cells resistant to cisplatin. Conversely enforced over-expression of TIE-1 was validated to decrease cisplatin sensitivity in multiple ovarian cancer cell lines and up-regulation of TIE-1 was correlated with poor prognosis and cisplatin resistance in patients with ovarian cancer. Read More

View Article
September 2018

Ficolin-1 is a promising therapeutic target for autoimmune diseases.

Int Immunol 2018 Aug 28. Epub 2018 Aug 28.

Department of Respiratory Medicine and Clinical Immunology, Graduate School of Medicine, Osaka University, Osaka, Japan.

Previously, we reported that mRNA expression of ficolin-1 (FCN1), a component of the complement lectin pathway, is elevated in peripheral blood mononuclear cells of patients with vasculitis syndrome, and that FCN1-positive cells infiltrate into inflamed regions in patient specimens. In addition, we reported that serum FCN1 concentration is elevated in patients with Kawasaki disease (KD), a pediatric vasculitis, but dramatically decreases after intravenous immunoglobulin (IVIG) treatment. Furthermore, we showed that FCN1 binds to IgG1 in a pull-down assay. Read More

View Article
August 2018
8 Reads

Structural basis of cross-reactivity of anti-citrullinated protein antibodies.

Arthritis Rheumatol 2018 Aug 27. Epub 2018 Aug 27.

Section for Medical Inflammation Research, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden.

Objectives: Anti-citrullinated protein antibodies (ACPAs) develop many years before the clinical onset of rheumatoid arthritis. Here we addressed the molecular basis of the specificity and cross-reactivity of ACPAs from patients with rheumatoid arthritis (RA).

Methods: Antibodies isolated from RA patients were expressed as monoclonal chimeric antibodies with mouse Fc and characterized for glycosylation using mass-spectrometry and cross-reactivity using Biacore and Luminex immunoassay. Read More

View Article
August 2018
7 Reads

Barbiturates enhance itch-associated scratching in atopic dermatitis mice: A possible clue to understanding nocturnal pruritus in atopic dermatitis.

Eur J Pharmacol 2018 Oct 18;836:57-66. Epub 2018 Aug 18.

Department of Pharmacology, Division of Pathological Sciences, Kyoto Pharmaceutical University, 5 Nakauchi-cho, Misasagi, Yamashina, Kyoto 607-8414, Japan; Department of Pharmacology, Graduate School of Medical Sciences, Nagoya City University, 1 Kawasumi, Mizuho-cho, Mizuho, Nagoya 467-8601, Japan.

In chronic pruritic diseases such as atopic dermatitis, pruritus is exacerbated during nocturnal sleep; however, the underlying mechanism remains unclear. We previously demonstrated that acute administration of the sedative-hypnotics ethanol markedly enhanced itch-associated spontaneous scratching in a diet-induced mouse model of atopic dermatitis. In the present study, to expand our previous finding and provide a general mechanism for the central modulation of chronic itch, we examined whether other hypnotic drugs, such as barbiturates and benzodiazepines, also enhance scratching, and further investigated the underlying mechanism. Read More

View Article
October 2018
13 Reads

Anti-inflammatory constituents from Perilla frutescens on lipopolysaccharide-stimulated RAW264.7 cells.

Fitoterapia 2018 Oct 16;130:61-65. Epub 2018 Aug 16.

Department of Natural medicinal Chemistry, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China. Electronic address:

Perilla frutescens (L.) Britt. (Lamiaceae) is a traditionally medicinal herb in East Asian countries to treat various diseases. Read More

View Article
October 2018
1 Read

Corrigendum to 'Toll-like receptors in immunity and inflammatory diseases: Past, present, and future' [International Immunopharmacology 59 (2018) 391-412].

Authors:
Vijay Kumar

Int Immunopharmacol 2018 09 7;62:338. Epub 2018 Jul 7.

Children's Health Clinical Unit, School of Clinical Medicine, Faculty of Medicine, Mater Research, University of Queensland, ST Lucia, Brisbane, Queensland 4078, Australia; School of Biomedical Sciences, Faculty of Medicine, University of Queensland, ST Lucia, Brisbane, Queensland 4078, Australia. Electronic address:

View Article
September 2018
2.470 Impact Factor

Design of the GutHeart-targeting gut microbiota to treat heart failure-trial: a Phase II, randomized clinical trial.

ESC Heart Fail 2018 10 7;5(5):977-984. Epub 2018 Aug 7.

Department of Cardiology, Oslo University Hospital, Rikshospitalet, Oslo, Norway.

Aims: Heart failure (HF) is a multifactorial disease. Current treatments target only a fraction of the putative pathophysiological pathways. In patients with HF, reduced cardiac output and congestion cause increased gut wall permeability. Read More

View Article
October 2018
1 Read

Myalgic Encephalomyelitis/Chronic Fatigue Syndrome-Metabolic Disease or Disturbed Homeostasis due to Focal Inflammation in the Hypothalamus?

J Pharmacol Exp Ther 2018 Oct 3;367(1):155-167. Epub 2018 Aug 3.

Second Department of Internal Medicine, Attikon General Hospital, Athens Medical School, Athens, Greece (E.H., M.A., G.D.); Laboratory of Molecular Immunopharmacology and Drug Discovery, Department of Immunology (I.T., T.C.T.) and Sackler School of Graduate Biomedical Sciences (T.C.T.), Tufts University School of Medicine, Boston, Massachusetts; and Departments of Internal Medicine and Psychiatry, Tufts University School of Medicine and Tufts Medical Center, Boston, Massachusetts (T.C.T.)

Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a complex disease characterized by debilitating fatigue, lasting for at least 6 months, with associated malaise, headaches, sleep disturbance, and cognitive impairment, which severely impacts quality of life. A significant percentage of ME/CFS patients remain undiagnosed, mainly due to the complexity of the disease and the lack of reliable objective biomarkers. ME/CFS patients display decreased metabolism and the severity of symptoms appears to be directly correlated to the degree of metabolic reduction that may be unique to each individual patient. Read More

View Article
October 2018
22 Reads

Critical role of inflammatory mast cell in fibrosis: Potential therapeutic effect of IL-37.

Cell Prolif 2018 Oct 30;51(5):e12475. Epub 2018 Jul 30.

Department of Integrative Physiology and Pathobiology, Molecular Immunopharmacology and Drug Discovery Laboratory, Tufts University School of Medicine, Boston, MA, USA.

Background: Fibrosis involves the activation of inflammatory cells, leading to a decrease in physiological function of the affected organ or tissue.

Aims: To update and synthesize relevant information concerning fibrosis into a new hypothesis to explain the pathogenesis of fibrosis and propose potential novel therapeutic approaches.

Materials And Methods: Literature was reviewed and relevant information is discussed in the context of the pathogenesis of fibrosis. Read More

View Article
October 2018
6 Reads

Activity of rheumatoid arthritis correlates with oral inflammatory burden.

Rheumatol Int 2018 09 24;38(9):1661-1669. Epub 2018 Jul 24.

Department of Rheumatology, Helsinki University Hospital, University of Helsinki, Helsinki, Finland.

To study oral health in patients with rheumatoid arthritis (RA) with emphasis on disease activity and treatment of RA. In this prospective cohort study 81 RA patients [53 early untreated RA (EURA) and 28 chronic RA (CRA) patients with inadequate response to synthetic disease modifying antirheumatic drugs (DMARDs)], underwent rheumatological [Disease Activity Score (28-joint) DAS28] and dental examinations [Total Dental Index (TDI), Decayed Missing Filled Teeth (DMFT) and Decayed Missing Filled Surfaces (DMFS)]. For controls, 43 volunteers were examined. Read More

View Article
September 2018
2 Reads

Accessing Expert-Curated Pharmacological Data in the IUPHAR/BPS Guide to PHARMACOLOGY.

Curr Protoc Bioinformatics 2018 Mar;61(1):1.34.1-1.34.46

Deanery of Biomedical Sciences, University of Edinburgh, Edinburgh, United Kingdom.

The IUPHAR/BPS Guide to PHARMACOLOGY is an expert-curated, open-access database of information on drug targets and the substances that act on them. This unit describes the procedures for searching and downloading ligand-target binding data and for finding detailed annotations and the most relevant literature. The database includes concise overviews of the properties of 1,700 data-supported human drug targets and related proteins, divided into families, and 9,000 small molecule and peptide experimental ligands and approved drugs that bind to those targets. Read More

View Article

Polymorphisms in the DAD1 and OXA1L genes are associated with asthma and atopy in a South American population.

Mol Immunol 2018 Sep 19;101:294-302. Epub 2018 Jul 19.

Laboratory of Immunopharmacology and Molecular Biology, Federal University of Bahia, Salvador, Brazil. Electronic address:

Atopic asthma, which is characterized by the chronic inflammation and morbidity of airways, is a disease of great complexity, and multiple genetic and environmental factors are involved in its etiology. In the first genome-wide association study (GWAS) conducted in Brazil for asthma, a positive association was found between atopic asthma and a variant (rs1999071), which is located between the DAD1 and OXA1L genes, although neither gene has previously been reported to be associated with asthma or allergies. The DAD1 gene is involved in the regulation of programmed cell death, and OXA1L is involved in biogenesis and mitochondrial oxidative phosphorylation. Read More

View Article
September 2018
7 Reads

PGL I expression in live bacteria allows activation of a CD206/PPARγ cross-talk that may contribute to successful Mycobacterium leprae colonization of peripheral nerves.

PLoS Pathog 2018 07 6;14(7):e1007151. Epub 2018 Jul 6.

Laboratory of Cellular Microbiology, Oswaldo Cruz Institute, Rio de Janeiro, RJ, Brazil.

Mycobacterium leprae, an obligate intracellular bacillus, infects Schwann cells (SCs), leading to peripheral nerve damage, the most severe leprosy symptom. In the present study, we revisited the involvement of phenolic glycolipid I (PGL I), an abundant, private, surface M. leprae molecule, in M. Read More

View Article
July 2018
8 Reads

Anti-rheumatic medication and salivary MMP-8, a biomarker for periodontal disease.

Oral Dis 2018 Nov 18;24(8):1562-1571. Epub 2018 Jul 18.

Department of Oral and Maxillofacial Diseases, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.

Objective: To investigate the impact of anti-rheumatic medications on salivary matrix metalloproteinase (MMP)-8 levels and MMP-8/TIMP (tissue inhibitor of MMPs)-1 ratio in patients with rheumatoid arthritis (RA) and periodontal findings during a 1-year follow-up.

Materials And Methods: Salivary MMP-8 was measured by an immunofluorometric assay and TIMP-1 by an enzyme-linked immunosorbent assay of 53 patients with early untreated RA (ERA), naïve to synthetic disease modifying anti-rheumatic drugs (DMARDs), of 28 patients with chronic RA (CRA), candidates for biologic DMARDs and of 43 age- and sex-matched controls. Periodontal health was evaluated by bleeding on probing (BOP), pocket depth (PD), and periodontal inflammatory burden index (PIBI). Read More

View Article
November 2018
11 Reads