1,896 results match your criteria Immunopharmacology and Immunotoxicology[Journal]


Meta-analysis on pharmacological therapies in the management of xerostomia in patients with Sjogren's syndrome.

Immunopharmacol Immunotoxicol 2019 Apr 1:1-7. Epub 2019 Apr 1.

b Department of Oral Medicine and Radiology , Government Dental College and Hospital , Hyderabad , India.

Introduction: Sjogren's syndrome is an immunologic disorder, characterized by symptoms of dry mouth and dry eyes. Management of xerostomia is more difficult and challenging, various pharmacologic agents have been tried and evaluated in the management of xerostomia in these patients, but the results were inconsistent and variable. Hence, the present study is aimed at evaluation and comparison of different pharmacological agents in the management of xerostomia in patients with Sjogren's syndrome. Read More

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http://dx.doi.org/10.1080/08923973.2019.1593448DOI Listing
April 2019
1 Read

Effects of sitagliptin and vitamin D3 on T helper cell transcription factors and cytokine production in clinical subgroups of type 2 diabetes mellitus: highlights upregulation of FOXP3 and IL-37.

Immunopharmacol Immunotoxicol 2019 Mar 25:1-13. Epub 2019 Mar 25.

a Department of Immunology, School of Medicine , Hamadan University of Medical Sciences , Hamadan , Iran.

Objective: Gene expression level of T helper cell transcription factors and cytokines production in type-2 diabetes mellitus (T2DM) patients treated with mono- or combined sitagliptin and vitamin D3 (VitD3) were evaluated.

Methods: Fifty-four nephropathic and 57 non-nephropathic T2DM patients were divided into the subgroups based on their treatment with/without sitagliptin and VitD3. The expression of T-bet, RORγt, BCL6, and FOXP3 was evaluated using real-time PCR. Read More

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https://www.tandfonline.com/doi/full/10.1080/08923973.2019.1
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http://dx.doi.org/10.1080/08923973.2019.1593447DOI Listing
March 2019
5 Reads
1.109 Impact Factor

Sinomenine regulates CD14/TLR4, JAK2/STAT3 pathway and calcium signal via α7nAChR to inhibit inflammation in LPS-stimulated macrophages.

Immunopharmacol Immunotoxicol 2019 Mar 21:1-6. Epub 2019 Mar 21.

a Department of Immunology, Institute of Clinical Pharmacology , Guangzhou University of Chinese Medicine , Guangzhou , P.R. China.

Objective: To investigate the cellular mechanism that sinomenine (SIN) inhibits inflammation in macrophages induced by LPS through α7 nicotinic acetylcholine receptor (α7nAChR).

Materials And Methods: RAW264.7 cells were stimulated with LPS and treated by SIN or nicotine (Nic). Read More

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http://dx.doi.org/10.1080/08923973.2019.1568451DOI Listing
March 2019
3 Reads

Morphine consumption is associated with systemic inflammation in children undergoing allogeneic hematopoietic stem cell transplantation.

Immunopharmacol Immunotoxicol 2019 Mar 20:1-7. Epub 2019 Mar 20.

a Department of Pediatrics and Adolescent Medicine , Copenhagen University Hospital, Rigshospitalet , Copenhagen , Denmark.

Background: The majority of children undergoing allogenic hematopoietic stem cell transplantation (HSCT) experience severe pain due to chemotherapy-induced gastrointestinal toxicity. Inter-individual differences in pain perceived and opioid consumption remain unexplained, limiting the possibility for individualized pain control. The aim of this study was to investigate the associations between opioid consumption and markers of gastrointestinal toxicity (plasma citrulline) and systemic inflammation (plasma CRP and IL-6) in these patients. Read More

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http://dx.doi.org/10.1080/08923973.2019.1590846DOI Listing
March 2019
1 Read

From the editors.

Immunopharmacol Immunotoxicol 2018 Dec;40(6):445

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http://dx.doi.org/10.1080/08923973.2019.1572270DOI Listing
December 2018

Effect of omega-3 fatty acid supplementation on resolvin (RvE1)-mediated suppression of inflammation in a mouse model of asthma.

Immunopharmacol Immunotoxicol 2019 Mar 8:1-8. Epub 2019 Mar 8.

a Division of Pharmaceutical Sciences, Arnold and Marie Schwartz College of Pharmacy and Health Sciences , Long Island University , Brooklyn , NY , USA.

Objective: ResolvinE1 (RvE1), an endogenous lipid mediator derived from omega 3 fatty acids contributes to resolution of allergic inflammatory responses. We investigated effects of RvE1 (R) and omega 3 fatty acids (O) on airway reactivity and inflammation using allergic mice.

Methods: Mice were divided into control (nonasthmatic; CON) and allergen sensitized-challenged (asthmatic; SEN) groups, and were sensitized i. Read More

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http://dx.doi.org/10.1080/08923973.2019.1584903DOI Listing
March 2019
1 Read

Inhibition of tumor necrosis factor alpha and increased of interleukin 10 by Lactobacillus: a molecular mechanism protection against TNBS-induced ulcerative colitis in chicks.

Immunopharmacol Immunotoxicol 2019 Mar 1:1-6. Epub 2019 Mar 1.

a Heilongjiang Key Laboratory of Laboratory Animal and Comparative Medicine , College of Veterinary Medicine, Northeast Agricultural University , Harbin , PR China.

The purpose of this study was to evaluate the effects and mechanism of Lactobacillus on ameliorating ulcerative colitis chicks induced by 2,4,6-trinitrobenzene sulfonic acid (TNBS). There are three groups in this study, control, Lactobacillus and ulcerative colitis groups. 1-day-old chicks were fed with microcapsules containing Lactobacillus LA-5 daily for Lactobacillus group and clustered with 2,4,6-trinitrobenzene sulfonic acid (TNBS) to make the model of ulcerative colitis at ten-day-old. Read More

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http://dx.doi.org/10.1080/08923973.2019.1566360DOI Listing

Agmatine ameliorates acetic acid-induced colitis in rats: involvement of nitrergic system.

Immunopharmacol Immunotoxicol 2019 Mar 1:1-8. Epub 2019 Mar 1.

a Department of Pharmacology, School of Medicine , Tehran University of Medical Sciences , Tehran , Iran.

Aim: The aim of the present study is to investigate the anti-inflammatory effect of agmatine through the inhibition of iNOS enzyme in acetic acid-induced rat colitis.

Methods: Acute colitis was induced by administration of 2 mL of diluted acetic acid (4%) solution rectally. Two hours after colitis induction, animals were treated with normal saline, dexamethasone (2 mg/kg), agmatine (2, 5, 10 mg/kg), L-NAME (30 mg/kg), Aminoguanidine (20 mg/kg), agmatine (2 mg/kg) with L-NAME (30 mg/kg) and agmatine (2 mg/kg) with aminoguanidine (20 mg/kg) intraperitoneally and continued for 3 consecutive days. Read More

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http://dx.doi.org/10.1080/08923973.2019.1578973DOI Listing
March 2019
7 Reads

Tachykinin upregulation in atopic dermatitis.

Immunopharmacol Immunotoxicol 2019 Feb 18:1-6. Epub 2019 Feb 18.

a Department of Medicine Solna, Dermatology and Venereology Unit , Karolinska Institutet , Stockholm , Sweden.

Context: Atopic dermatitis (AD) is a chronic, inflammatory, itching skin disorder, which may worsen due to stress, depression and anxiety. Tachykinins may be involved in inflammation signaling as well as they may have a role in stress, depression and anxiety.

Objective: This study aimed to measure the expression of tachykinin markers, in the skin of patients with AD, and the correlation of these tachykinins with clinical and psychodemographic parameters. Read More

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http://dx.doi.org/10.1080/08923973.2018.1558235DOI Listing
February 2019
1 Read

Protective effect of a topical sunscreen formulation fortified with melatonin against UV-induced photodermatitis: an immunomodulatory effect via NF-κB suppression.

Immunopharmacol Immunotoxicol 2019 Feb 11:1-10. Epub 2019 Feb 11.

a Division of Pharmaceutical Technology , Defence Research Laboratory , Tezpur , India.

Objective: Melatonin and pumpkin seed oil, along with US FDA approved UV filters were incorporated into a formulation for enhancement of UV protection by exerting an antioxidant effect. The objective of this study was to assess the protective effect of this formulation against ultraviolet (UV) radiation-induced photo dermatitis in rats, which is an established model to study the aetiopathogenic mechanisms in psoriasis vulgaris, as the former exhibits the same features to those of clinical psoriasis vulgaris in humans.

Materials And Methods: The animals were segregated into five groups (6/group) and all received their respective formulations dermally prior to chronic UV irradiation for 28 days. Read More

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http://dx.doi.org/10.1080/08923973.2019.1566358DOI Listing
February 2019
1.109 Impact Factor

Silica nanoparticles as an enhancer in the IL-1β-induced inflammation cycle of A549 cells.

Immunopharmacol Immunotoxicol 2019 Feb 6:1-8. Epub 2019 Feb 6.

a Department of Pathogen Biology, School of Medicine , Jinan University , Guangzhou , China.

Objective: The industrial production and combustion of coal can produce silica nanoparticles (nano-SiO). It enters the human body mainly through the respiratory tract and exerts a toxic effect. However, whether nano-SiO can increase the IL-1β-induced inflammatory expression in A549 cells has not been tested. Read More

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http://dx.doi.org/10.1080/08923973.2019.1569046DOI Listing
February 2019
3 Reads
1.109 Impact Factor

Dehydroxymethylepoxyquinomicin suppresses atopic dermatitis-like lesions in a stratum corneum-removed murine model through NF-κB inhibition.

Immunopharmacol Immunotoxicol 2019 Feb 6:1-8. Epub 2019 Feb 6.

a School of Life Science and Biopharmaceutics , Shenyang Pharmaceutical University , Shenyang , China.

Background: Dehydroxymethylepoxyquinomicin (DHMEQ) is a specific and potent inhibitor of nuclear factor-kappa B (NF-κB) and has been shown to possess promising potential as an anti-inflammation including anti-atopic dermatitis (AD)-like skin lesions.

Objective: To further evaluate the activity of DHMEQ in vivo modified AD-like lesion model in BALB/c mice and in vitro AD-like lesion cell model in human keratinocytes.

Materials And Methods: In this study, in vivo modified AD-like lesion model in BALB/c mice was chronically induced by the repetitive and alternative application of 2,4-dinitrochlorobenzene (DNCB) and oxazolone (OX) on ears, and stratum corneum of the ear skin was additionally stripped off with surgical tapes before each challenge with DNCB/OX. Read More

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http://dx.doi.org/10.1080/08923973.2018.1510962DOI Listing
February 2019
3 Reads

Phillygenin exhibits anti-inflammatory activity through modulating multiple cellular behaviors of mouse lymphocytes.

Immunopharmacol Immunotoxicol 2019 Feb 5:1-10. Epub 2019 Feb 5.

a State Key Laboratory of Generic Manufacture Technology of Chinese Traditional Medicine , Linyi , PR China.

Context: Phillygenin (PHI) is an intestinal metabolite of phillyrin from the genus Forsythia. Although the regulatory activity of Forsythia on immune system has been investigated, the effect of PHI on activated lymphocytes is poorly understood.

Objective: This study was aimed to discuss the possible anti-inflammation potential of PHI on mitogen-activated stimulated lymphocytes in vitro. Read More

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http://dx.doi.org/10.1080/08923973.2018.1547742DOI Listing
February 2019
2 Reads

Fluconazole induces genotoxicity in cultured human peripheral blood mononuclear cells via immunomodulation of TNF-α, IL-6, and IL-10: new challenges for safe therapeutic regimens.

Immunopharmacol Immunotoxicol 2019 Feb 5:1-7. Epub 2019 Feb 5.

a Graduate Program in Pharmaceutical Sciences, Federal University of Pampa , Uruguaiana , Brazil.

Context: Fluconazole (FNZ) is a drug used in antifungal therapy. However, the minimum FNZ dose to interfering with immune responses or inducing DNA damage is still unknown.

Objective: This study investigated the toxicological profile of FNZ on cultured human peripheral blood mononuclear cells (PBMCs) treated with different concentrations of this azole. Read More

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http://dx.doi.org/10.1080/08923973.2019.1566357DOI Listing
February 2019

The antagonistic effect of tamoxifen against d-galactosamine/lipopolysaccharide-induced acute liver failure is associated with reactivation of hepatic nuclear factor-κB.

Immunopharmacol Immunotoxicol 2019 Feb 5:1-7. Epub 2019 Feb 5.

a The Affiliated Ganzhou Hospital of Nanchang University , Ganzhou , Jiangxi , China.

Context: Tamoxifen (TAM) ameliorates D-galactosamine/lipopolysaccharide (Gal/LPS)-induced acute liver failure (ALF) through its antioxidative effect; thus, this study was designed to determine whether the effectiveness of TAM is related to nuclear factor-κB (NF-κB) reactivation.

Materials And Methods: Experimental mice were injected with TAM once daily for 3 consecutive days intraperitoneally (i.p). Read More

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http://dx.doi.org/10.1080/08923973.2019.1569044DOI Listing
February 2019
1 Read

Anti-TNF effect of combined pravastatin and cilostazol treatment in an in vivo mouse model.

Immunopharmacol Immunotoxicol 2019 Feb 4:1-6. Epub 2019 Feb 4.

a Laboratory of Pharmaco-Immunology, Integrated Research Institute of Pharmaceutical Sciences, BK21 PLUS Team for Creative Leader Program for Pharmacomics-Based Future Pharmacy, College of Pharmacy , The Catholic University of Korea , Bucheon , Republic of Korea.

Objectives: Pravastatin and cilostazol are used as lipid-lowering and antiplatelet agents, respectively. Regarding their well-known anti-inflammatory effects, the additive effect of the two drugs on anti-TNF functions has not yet been investigated. In the present investigation, the beneficial effect of combined pravastatin and cilostazol on their anti-TNF activities was assessed using an in vivo mouse model. Read More

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http://dx.doi.org/10.1080/08923973.2019.1569045DOI Listing
February 2019
1 Read

Survival of lymphocytes is not restricted by IDO-expressing fibroblast from rheumatoid arthritis patients.

Immunopharmacol Immunotoxicol 2019 Feb 4:1-10. Epub 2019 Feb 4.

a Department of Pathophysiology and Immunology , National Institute of Geriatrics, Rheumatology, and Rehabilitation , Warsaw , Poland.

Objective: Rheumatoid arthritis (RA) is characterized by expansion of fibroblast-like synoviocytes (FLS) in inflamed joints and activation of lymphocytes. Tryptophan (trp) is an essential amino acid indispensable for the biosynthesis of proteins and critical for survival of lymphocytes. Indoleamine 2,3-dioxygenase (IDO) that initiates the degradation of trp and tryptophanyl-tRNA synthetase (TTS) essential for tryptophan synthesis, regulate trp bioavailability. Read More

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http://dx.doi.org/10.1080/08923973.2019.1569048DOI Listing
February 2019
3 Reads

Preclinical evidences of safety of a new synthetic adjuvant to formulate with the influenza human vaccine: absence of subchronic toxicity and mutagenicity.

Immunopharmacol Immunotoxicol 2019 Feb 4:1-10. Epub 2019 Feb 4.

a Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México , Ciudad de México , Mexico.

Context: Influenza is a severe, life-threatening viral disease that can be prevented by vaccination. However, the anti-influenza human vaccine failed to show the required efficacy both in infants under 5 years old and in the elder population, who are among those with the highest risk of developing severe complications after influenza infection. Therefore, it is of high importance to improve the vaccine efficacy and ensure its safety in these susceptible populations. Read More

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http://dx.doi.org/10.1080/08923973.2019.1566359DOI Listing
February 2019
1 Read

The role of T helper 17 and regulatory T cells in tumor microenvironment.

Immunopharmacol Immunotoxicol 2019 Feb 4:1-9. Epub 2019 Feb 4.

b Department of Immunology , School of Public Health, Tehran University of Medical Sciences , Tehran , Iran.

T helper 17 (Th17) cells were first described as a novel T helper cell lineage independent from Th1 and Th2 subsets. Th17 cells play vital roles in inflammation and tumor immunity. It causes the dissipation of antitumor immunity and contribution to the survival of tumor cells, worsening tumor growth and metastasis. Read More

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http://dx.doi.org/10.1080/08923973.2019.1566925DOI Listing
February 2019
1 Read
1.109 Impact Factor

The germ-free mice monocolonization with Bacteroides fragilis improves azoxymethane/dextran sulfate sodium induced colitis-associated colorectal cancer.

Immunopharmacol Immunotoxicol 2019 Feb 1:1-7. Epub 2019 Feb 1.

h National Laboratory Animal Center , National Applied Research Laboratories , Taipei , Taiwan.

Objective: Inflammatory bowel disease (IBD) is generally considered as a major risk factor in the progression of colitis-associated colorectal cancer (CAC). Previous studies have indicated that the composition of gut microflora may be involved in CAC induction and progress. Bacteroides fragilis (BF) is a Gram-negative anaerobe belonging to colonic symbiotic bacteria of the host. Read More

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http://dx.doi.org/10.1080/08923973.2019.1569047DOI Listing
February 2019
1 Read

Carvacrol ameliorates the progression of liver fibrosis through targeting of Hippo and TGF-β signaling pathways in carbon tetrachloride (CCl)-induced liver fibrosis in rats.

Immunopharmacol Immunotoxicol 2019 Feb 1:1-9. Epub 2019 Feb 1.

c Department of Pathobiology , Veterinary Medicine Faculty Razi University , Kermanshah , Iran.

Objective: Little is known about the exact underlying molecular mechanisms of the hepatoprotective effect of carvacrol against liver fibrosis. In the current study, we aimed to investigate the effect of carvacrol on the suppression of liver fibrosis progression via regulation of yes-associated protein (YAP) and transcriptional coactivators with a PDZ-binding motif (TAZ) and transforming growth factor beta (TGF-β) pathway.

Materials And Methods: To fulfill our target, rats received carbon tetrachloride (CCl) and carvacrol intraperitoneally, and orally, respectively for 10 weeks. Read More

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http://dx.doi.org/10.1080/08923973.2019.1566926DOI Listing
February 2019
1 Read

Hematological and immunological impairment following in-utero and postnatal exposure to aluminum sulfate in female offspring of albino rats.

Authors:
Ghada A Omran

Immunopharmacol Immunotoxicol 2019 Feb 1:1-8. Epub 2019 Feb 1.

a Faculty of Medicine, Forensic Medicine and Clinical toxicology department , Assiut University , Assiut , Egypt.

Aim: Aluminum (Al) is a ubiquitous element extensively utilized in many products like food additives, pharmaceuticals, and vaccines, but its hematotoxic and immunotoxic effects are not entirely clarified. The present study explored the developmental hematotoxic and immunotoxic properties of aluminum sulfate (AS) in rats' offspring.

Methods: Forty female offspring (10 rats each) were given three incremental AS doses plus a control group, from conception through lactation and after weaning until reached eight weeks old (near adults). Read More

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http://dx.doi.org/10.1080/08923973.2018.1533967DOI Listing
February 2019
1 Read

Sclareol attenuates the development of atopic dermatitis induced by 2,4-dinitrochlorobenzene in mice.

Immunopharmacol Immunotoxicol 2019 Feb 1:1-8. Epub 2019 Feb 1.

f Department of Medical Research , China Medical University Hospital , Taichung , Taiwan.

Context: Atopic dermatitis is a common chronic inflammatory skin disease affecting up to 20% of children and 1% of adults worldwide. Treatment of atopic dermatitis include corticosteroids and immunosuppressants, such as calcineurin inhibitors and methotrexate. However, these treatments often bring about adverse effects including skin atrophy, osteoporosis, skin cancer, and metabolic syndrome. Read More

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http://dx.doi.org/10.1080/08923973.2018.1555846DOI Listing
February 2019
4 Reads

Modulating acute neuroinflammation in intracerebral hemorrhage: the potential promise of currently approved medications for multiple sclerosis.

Immunopharmacol Immunotoxicol 2019 Jan 31:1-9. Epub 2019 Jan 31.

b Department of Emergency Medicine , University of Cincinnati , Cincinnati , OH , USA.

The secondary inflammatory injury following intracerebral hemorrhage (ICH) results in increased morbidity and mortality. White blood cells have been implicated as critical mediators of this inflammatory injury. Currently, no medications have been clinically proven to ameliorate or beneficially modulate inflammation, or to improve outcomes by any mechanism, following ICH. Read More

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http://dx.doi.org/10.1080/08923973.2019.1566361DOI Listing
January 2019
1 Read

Effects of tacrolimus (FK506) and mycophenolate mofetil (MMF) on regulatory T cells and co-inhibitory receptors in the peripheral blood of human liver allograft patients.

Immunopharmacol Immunotoxicol 2019 Jan 11:1-6. Epub 2019 Jan 11.

d Department of General Surgery , Fourth Hospital of Hebei Medical University , Shijiazhuang , China.

Context: Recent studies have shown that a combination treatment of mycophenolate mofetil (MMF) and tacrolimus (FK506) may be an option for organ transplantation patients.

Objective: In this study, we detected the effects of FK506 and MMF on the expressions of regulatory T cells (Tregs) and co-inhibitory receptors on Tregs in peripheral blood mononuclear cells (PBMC) of patients with stable phase after liver transplantation.

Materials And Methods: A total of 35 patients with stable stage after 6 months of liver transplantation were divided into two groups including 20 patients were treated with FK506 monotherapy (FK506 group), and 15 patients with FK506 and MMF combination (FK506 + MMF group). Read More

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http://dx.doi.org/10.1080/08923973.2018.1533026DOI Listing
January 2019
16 Reads
1.109 Impact Factor

Anti-inflammatory potential of pyocyanin in LPS-stimulated murine macrophages.

Immunopharmacol Immunotoxicol 2019 Jan 9:1-7. Epub 2019 Jan 9.

a Departamento de Biologia Celular e Molecular , Universidade Federal da Paraíba , João Pessoa , Brazil.

Context: Pyocyanin is a typical Pseudomonas aeruginosa virulence factor, a common Gram-negative rod responsible for a wide range of severe nosocomial infections. There is evidence indicating that pyocyanin has multiple biological activities, but little is known about anti-inflammatory properties.

Objective: This study investigated pyocyanin effect on nitric oxide and cytokine production in lipopolysaccharide (LPS)-activated murine peritoneal macrophages. Read More

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http://dx.doi.org/10.1080/08923973.2018.1555845DOI Listing
January 2019
3 Reads

A randomized clinical trial for the assessment of the efficacy and safety of guluronic acid (G2013) in patients with rheumatoid arthritis.

Immunopharmacol Immunotoxicol 2019 Jan 9:1-7. Epub 2019 Jan 9.

a Department of Immunology, School of Public Health , Tehran University of Medical Sciences , Tehran , Iran.

Objective: To evaluate the safety, efficacy and tolerability of guluronic acid (G2013) in order to treat the rheumatoid arthritis patients who had inadequate response to conventional drugs.

Methods: A randomized, 12-week clinical trial with two treatment arms: guluronic acid (G2013) and conventional treatment was performed. The diagnosed RA patients according to the ACR/European League against Rheumatism 2010 classification criteria, with an active disease at baseline that had inadequate response to conventional therapy were considered for the study. Read More

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https://www.tandfonline.com/doi/full/10.1080/08923973.2018.1
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http://dx.doi.org/10.1080/08923973.2018.1555844DOI Listing
January 2019
10 Reads
1.109 Impact Factor

A new triple chimeric protein as a high immunogenic antigen against anthrax toxins: theoretical and experimental analyses.

Immunopharmacol Immunotoxicol 2019 Jan 9:1-7. Epub 2019 Jan 9.

b Faculty of Biological Sciences , Tarbiat Modares University , Tehran , Iran.

Background: Anthrax is a zoonotic disease caused by Bacillus anthracis and it can be deadly in 6 days. Considerable efforts have been conducted toward developing more effective veterinary and human anthrax vaccines because these common vaccines have several limitations. B. Read More

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https://www.tandfonline.com/doi/full/10.1080/08923973.2018.1
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http://dx.doi.org/10.1080/08923973.2018.1510419DOI Listing
January 2019
13 Reads
1.109 Impact Factor

Differential effect of NDGA on cisplatin-induced nephrotoxicity in Spargue-Dawley rats.

Immunopharmacol Immunotoxicol 2019 Jan 3:1-8. Epub 2019 Jan 3.

d Department of Pharmacology, Gauhati Medical College and Hospital , Bhangagarh , Guwahati, Assam , India.

Context: Nephrotoxicity is a highly manifested complication in cancer patients undergoing cisplatin therapy. Oxidative stress, nitrosative stress, and inflammation are the major patho-mechanisms of cisplatin-induced nephrotoxicity.

Objective: The purpose of this study was to determine the protective effect of pretreatment and post-treatment of nordihydroguaiarectic acid (NDGA) on cisplatin-induced nephrotoxicity. Read More

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https://www.tandfonline.com/doi/full/10.1080/08923973.2018.1
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http://dx.doi.org/10.1080/08923973.2018.1547741DOI Listing
January 2019
8 Reads

Inhibition of LPS-induced brain injury by NR2B antagonists through reducing assembly of NR2B-CaMKII-PSD95 signal module.

Immunopharmacol Immunotoxicol 2019 Jan 3:1-9. Epub 2019 Jan 3.

f Department of Anatomy , Xuzhou Medical University , Xuzhou , Jiangsu, People's Republic of China.

Background: Accumulating evidence suggests that inflammation is a contributor to the cause and progression of neurodegenerative disease, such as Alzheimer's disease (AD) and Parkinson disease (PD). However, the exact mechanisms of neuroinflammation are still unclear. Here, we discussed the potential mechanisms of lipopolysaccharide (LPS)-induced brain injury via NR2B antagonists (Ro25-6981) treatment in mice. Read More

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http://dx.doi.org/10.1080/08923973.2018.1549566DOI Listing
January 2019
1 Read

Phyllanthin and hypophyllanthin from Phyllanthus amarus ameliorates immune-inflammatory response in ovalbumin-induced asthma: role of IgE, Nrf2, iNOs, TNF-α, and IL's.

Immunopharmacol Immunotoxicol 2018 Dec 12:1-13. Epub 2018 Dec 12.

a Department of Pediatrics , The First Affiliated Hospital of Nanjing Medical University , Nanjing , Jiangsu , P.R. China.

Background: Asthma is a chronic airway immunoinflammatory disorder characterized by airway remodeling. Phyllanthus amarus has been reported to possess antioxidant and anti-inflammatory potential.

Aim: To evaluate the possible mechanism of action of isolated phytoconstituents from P. Read More

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http://dx.doi.org/10.1080/08923973.2018.1545788DOI Listing
December 2018
2 Reads

Autologous canine immunotherapy: short-time generated dendritic cells loaded with canine transmissible venereal tumor-whole lysate.

Immunopharmacol Immunotoxicol 2018 Oct 3;40(5):437-443. Epub 2018 Dec 3.

a Virology and Immunology Laboratory, Biological Science Faculty , Autonomous University of Nuevo León (AUNL) , San Nicolás de los Garza , México.

Objective: The aim of the present study was to evaluate the therapeutic potential of autologous DCs loaded with whole tumor cell lysate of CTVT generated under a simplified and rapid procedure in vitro production process, in a vulvar submucosal model of CTVT in dogs.

Materials And Methods: We generated a model of intravulvar CTVT in dogs. A CTVT lysate antigen was prepared according to the method of 1-butanol and after administered with complete Freund's adjuvant via subcutaneous in female healthy dogs and challenge with CTVT cells to corroborate the immunogenicity. Read More

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https://www.tandfonline.com/doi/full/10.1080/08923973.2018.1
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http://dx.doi.org/10.1080/08923973.2018.1523928DOI Listing
October 2018
19 Reads

Protective effect of sesamin in lipopolysaccharide-induced mouse model of acute kidney injury via attenuation of oxidative stress, inflammation, and apoptosis.

Immunopharmacol Immunotoxicol 2018 Oct 29;40(5):423-429. Epub 2018 Nov 29.

d Department of Physiology, Neurophysiology Research Center , Shahed University , Tehran , Iran.

Context: Acute kidney injury (AKI) is considered a major public health concern in today's world. Sepsis-induced AKI is large as a result of exposure to lipopolysaccharide (LPS) that is the major outer membrane component of Gram-negative bacteria. Sesamin is the main lignan of sesame seeds with multiple protective effects. Read More

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https://www.tandfonline.com/doi/full/10.1080/08923973.2018.1
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http://dx.doi.org/10.1080/08923973.2018.1523926DOI Listing
October 2018
20 Reads
1.109 Impact Factor

miR-130b participates in wear particle-induced inflammation and osteolysis via FOXF2/NF-κB pathway.

Immunopharmacol Immunotoxicol 2018 Oct 29;40(5):408-414. Epub 2018 Nov 29.

a Department of Joint Surgery , Tianjin Hospital , Tianjin , P.R. China.

Objective: To reveal other miR-130b-mediated signaling pathway in the involvement of wear particle-induced inflammation and osteolysis.

Materials And Methods: Particle-induced osteolysis (PIO) mice model was established. Secretion levels of TNF-α, IL-1β, IL-6, and IL-10 were measured by ELISA. Read More

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http://dx.doi.org/10.1080/08923973.2018.1514626DOI Listing
October 2018
16 Reads

Stem cells therapy: a review on approaches that can be used for treatment of respiratory failures in sulfur mustard-injured patients.

Immunopharmacol Immunotoxicol 2018 Oct 29;40(5):359-367. Epub 2018 Nov 29.

c Chemical Injuries Research Center, Systems Biology and Poisonings Institute , Baqiyatallah University of Medical Sciences , Tehran , Iran.

Sulfur mustard (SM) is a toxic agent which causes severe abnormalities in an airway system such as necrosis and inflammation, oxidative stress, chronic bronchitis, shortness of breath, and chronic obstructive pulmonary disease. Although possible mechanisms of SM toxicity have been extensively considered, there is still need to find an appropriate clinical treatment to decrease chronic lung injuries caused by SM. Due to extensive progresses and achievement in tissue repairing through stem cells therapy, the importance of cell therapy for the treatment of lung injuries has been increased. Read More

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https://www.tandfonline.com/doi/full/10.1080/08923973.2018.1
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http://dx.doi.org/10.1080/08923973.2018.1510961DOI Listing
October 2018
11 Reads
1.109 Impact Factor

XAV939, a Wnt/β-catenin pathway modulator, has inhibitory effects on LPS-induced inflammatory response.

Immunopharmacol Immunotoxicol 2018 Nov 22:1-9. Epub 2018 Nov 22.

a Department of Microbiology , Chung-Ang University College of Medicine , Seoul , Republic of Korea.

Aim: In this study, we report the anti-inflammatory activity of XAV939, a modulator of the Wnt/β-catenin pathway.

Methods: WNT/β-catenin pathway and NF-κB signaling pathway were examined in LPS-stimulated human bronchial epithelial cells and effects of XAV939 on these pathways were analyzed. The effect of XAV939 was confirmed in human umbilical vein endothelial cells. Read More

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http://dx.doi.org/10.1080/08923973.2018.1536984DOI Listing
November 2018
1 Read

Radiation-induced lung injury: impact on macrophage dysregulation and lipid alteration - a review.

Immunopharmacol Immunotoxicol 2018 Nov 16:1-10. Epub 2018 Nov 16.

b School of Biomedical Informatics , The University of Texas Health Sciences Center , Houston , TX , USA.

Lung cancer continues to be the leading cause of cancer deaths and more than one million lung cancer patients will die every year worldwide. Radiotherapy (RT) plays an important role in lung cancer treatment, but the side effects of RT are pneumonitis and pulmonary fibrosis. RT-induced lung injury causes damage to alveolar-epithelial cells and vascular endothelial cells. Read More

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http://dx.doi.org/10.1080/08923973.2018.1533025DOI Listing
November 2018
6 Reads

Alpha- and gamma-mangostins exhibit anti-acne activities via multiple mechanisms.

Immunopharmacol Immunotoxicol 2018 Nov 13:1-8. Epub 2018 Nov 13.

a Institute of Life Science , Wenzhou University , Wenzhou , China.

Objective: Acne is a chronic skin disease that involves four key pathogenic factors: excess sebum production, ductal epidermal hyperproliferation, Propionibacterium acnes (P. acnes) colonization, and skin inflammation. Mangostins are well-known for their anti-bacterial and anti-inflammatory effects, suggesting that mangostins may have therapeutic potential for acne. Read More

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https://www.tandfonline.com/doi/full/10.1080/08923973.2018.1
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http://dx.doi.org/10.1080/08923973.2018.1519831DOI Listing
November 2018
26 Reads

Polydatin protects against ovalbumin-induced bronchial asthma in rats; involvement of urocortin and surfactant-D expression.

Immunopharmacol Immunotoxicol 2018 Nov 13:1-10. Epub 2018 Nov 13.

a Department of Pharmacology and Toxicology Faculty of Pharmacy , Nahda University , Beni-Suef , Egypt.

Context: Prevalence of bronchial asthma massively increases worldwide, while the frequent therapies are still not sufficient. Polydatin, a naturally occurring glycoside, was known as to have anti-inflammatory and anti-oxidant effects.

Objective: The current study aimed to investigate the possible protective effect of polydatin against experimental bronchial asthma in rats. Read More

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https://www.tandfonline.com/doi/full/10.1080/08923973.2018.1
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http://dx.doi.org/10.1080/08923973.2018.1536985DOI Listing
November 2018
17 Reads

Identification of discrepancy between CTLA4 expression and CTLA4 activation in gastric cancer.

Immunopharmacol Immunotoxicol 2018 Nov 13:1-8. Epub 2018 Nov 13.

e Department of Gastrointestinal Surgery , The General Hospital of Ningxia Medical University , Yinchuan , China.

Objective: Recently, immune checkpoints blockers showed higher anti-tumor activity for advanced gastric cancer (GC). The purpose of the study is to find out predictive biomarkers related to anti-cytotoxic lymphocyte antigen 4 (CTLA4) therapy.

Materials And Methods: Datasets of gene expression omnibus (GEO), the cancer genome atlas (TCGA), and gene set enrichment analysis (GESA) were extracted. Read More

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https://www.tandfonline.com/doi/full/10.1080/08923973.2018.1
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http://dx.doi.org/10.1080/08923973.2018.1533968DOI Listing
November 2018
15 Reads

Suppressive oligodeoxynucleotide-induced dendritic cells rein the aggravation of osteoarthritis in mice.

Immunopharmacol Immunotoxicol 2018 Oct 26;40(5):430-436. Epub 2018 Oct 26.

a Department of Orthopedics , Affiliated Hospital of Guangdong Medical University , Zhanjiang , Guangdong , People's Republic of China.

Objective: To explore the effect of suppressive oligodeoxynucleotide-induced dendritic cells (S-DCs) in the osteoarthritis (OA) therapy.

Methods: S-DCs were prepared from splenic CD11c + cells by in vitro culture with suppressive oligodeoxynucleotide. The function and phenotypes of S-DCs were measured by ELISA and flow cytometry. Read More

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https://www.tandfonline.com/doi/full/10.1080/08923973.2018.1
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http://dx.doi.org/10.1080/08923973.2018.1523927DOI Listing
October 2018
26 Reads

Immunotherapy for the treatment of canine transmissible venereal tumor based in dendritic cells pulsed with tumoral exosomes.

Immunopharmacol Immunotoxicol 2018 Oct 18:1-21. Epub 2018 Oct 18.

a Virology and Immunology Laboratory, Biological Science Faculty , Autonomous University of Nuevo León (UANL) , San Nicolás de los Garza , N. L. México . PO BOX 46 "F" Zip Code 66455.

Exosomes secreted by tumor cells are a good source of cellular components that stimulate the immune response, such as alarmins (mRNA, tetraspanins (CD9, CD63, CD81), heat-shock proteins, major histocompatibility complex class I molecules) and tumor-associated antigens. These properties permit to pulsed dendritic cells in the immunotherapy for many cancers types. The aim of this study was to demonstrate the use of exosomes derived from canine transmissible venereal tumor (CTVT) as an antigen to pulsed dendritic cells and its administration in dogs with CTVT as treatment against this disease. Read More

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https://www.tandfonline.com/doi/full/10.1080/08923973.2018.1
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http://dx.doi.org/10.1080/08923973.2018.1533969DOI Listing
October 2018
11 Reads
1.110 Impact Factor

Increased inflammatory responsiveness of peripheral blood mononuclear cells (PBMCs) to in vitro NOD2 ligand stimulation in patients with ankylosing spondylitis.

Immunopharmacol Immunotoxicol 2018 Sep 28:1-8. Epub 2018 Sep 28.

b Rheumatology Research Center, Tehran University of Medical Sciences , Tehran , Iran.

Background: Ankylosing spondylitis (AS) is a common debilitating rheumatic disease in which the innate immune components especially the Interleukin (IL)-23/IL-17 axis related genes play important role in its pathogenesis. Nucleotide binding oligomerization domain-containing protein (NOD)2, as an innate receptor, is critical for IL-23 production in cells. Therefore, we aimed to stimulate NOD2 signaling and study its effects on cytokine production in peripheral blood mononuclear cells (PBMC) of these patients. Read More

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http://dx.doi.org/10.1080/08923973.2018.1510963DOI Listing
September 2018
4 Reads

Enhanced CD40 and ICOSL expression on dendritic cells surface improve anti-tumor immune responses; effectiveness of mRNA/chitosan nanoparticles.

Immunopharmacol Immunotoxicol 2018 Sep 28:1-12. Epub 2018 Sep 28.

b Department of Biotechnology, Faculty of Medical Sciences , Tarbiat Modares University , Tehran , Iran.

Objective: To improve dendritic cells (DCs) function, we targeted DCs to over express CD40 and inducible costimulator ligand (ICOSL) costimulatory molecules along with total messenger RNA (mRNA) of tumor cells to achieve a safe and effective system for treatment of tumor.

Materials And Methods: We generated CD40 and ICOSL mRNA in vitro and manipulated DCs using chitosan nanoparticles and also lipofectamine transfection system then examined in vitro and in vivo.

Results: Mice bone marrow derived DCs pulsed with total tumor mRNA/CD40 mRNA or ICOSL mRNA showed higher expression of DCs maturation markers (CD40, ICOSL, CD86, and MHC-II) and accelerated secretion of pro-inflammatory cytokines. Read More

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https://www.tandfonline.com/doi/full/10.1080/08923973.2018.1
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http://dx.doi.org/10.1080/08923973.2018.1510959DOI Listing
September 2018
4 Reads

Cordycepin ameliorates skin inflammation in a DNFB-challenged murine model of atopic dermatitis.

Immunopharmacol Immunotoxicol 2018 Oct 5;40(5):401-407. Epub 2018 Sep 5.

c Department of Food Science & Technology and Research Institute for Basic Science , Hoseo University , Chungnam , Republic of Korea.

Objectives: Atopic dermatitis (AD) is an allergic and inflammatory skin disorder caused by a combination of itching and skin sensitization by allergens. This article investigated whether cordycepin modulates AD symptoms by using an AD murine model.

Material And Methods: We evaluated a regulatory effect and specific molecular mechanism of cordycepin on AD induced by the repeated local exposure of 2,4-dinitrochlorobenzene to dorsal skin of mice. Read More

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http://dx.doi.org/10.1080/08923973.2018.1510964DOI Listing
October 2018
3 Reads

An antibody fragment against human delta-like ligand-4 for inhibition of cell proliferation and neovascularization.

Immunopharmacol Immunotoxicol 2018 Oct 5;40(5):368-374. Epub 2018 Sep 5.

d National Cell Bank of Iran, Pasteur Institute of Iran , Tehran , Iran.

Objectives: Angiogenesis targeting is an attractive approach for cancer treatment. Delta-like ligand 4 (DLL4) plays a pivotal role in neovascular development and its inhibitors have recently entered clinical trials for solid tumors. The aim of this study was to evaluate the possibilities of using anti-DLL4 antibody fragment as an angiogenesis maturation inhibitor. Read More

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http://dx.doi.org/10.1080/08923973.2018.1505907DOI Listing
October 2018
3 Reads

Concanavalin-A displays leishmanicidal activity by inducing ROS production in human peripheral blood mononuclear cells.

Immunopharmacol Immunotoxicol 2018 Sep 5:1-6. Epub 2018 Sep 5.

a Department of Pathological Sciences , Center of Biological Sciences, State University of Londrina , Londrina , Paraná , Brasil.

The context of the article: Leishmania amazonensis has a wide geographical distribution throughout South American countries and can cause self-healing to severe cases as mucocutaneous or visceral forms. Leishmaniasis presents a balance of inflammatory and anti-inflammatory cytokines which is responsible for promoting the activation of phagocytes, essential to control the infection and lead to tissue repair/resolution of the disease, respectively.

Results And Discussion: Our model revealed that the treatment with Con-A was capable to stimulate human PBMC cells by increasing the phagocytic capacity and promoting parasite elimination. Read More

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http://dx.doi.org/10.1080/08923973.2018.1510960DOI Listing
September 2018
5 Reads

Enhancement of anti-tumor effect of plasmid DNA-carrying MUC1 by the adjuvanticity of FLT3L in mouse model.

Immunopharmacol Immunotoxicol 2018 Aug 15;40(4):353-357. Epub 2018 Aug 15.

a Department of Medicine , Beijing Tongren Hospital, Capital Medical University , Beijing , China.

Aim: DNA vaccines have emerged as a promising strategy for cancer immunotherapy; however, their immunogenicity is weak. Fms-like tyrosine kinase 3-ligand (Flt3L) has been exploited for its ability to increase the proliferation of dendritic cells (DCs). The aim of the present study was to investigate whether co-administration of an adjuvant plasmid expressing mouse Flt3L and a DNA vaccine of the Mucin 1 (MUC1) antigen enhances immune responses. Read More

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http://dx.doi.org/10.1080/08923973.2018.1498099DOI Listing
August 2018
2 Reads

Ketamine delays progression of oxidative and damaged cataract through regulating HMGB-1/NF-κB in lens epithelial cells.

Immunopharmacol Immunotoxicol 2018 Aug 15;40(4):303-308. Epub 2018 Aug 15.

a Department of Ophthalmology , The Second Affiliated Hospital of Zhejiang Chinese Medical University , Hangzhou , Zhejiang , China.

Objective: Lens epithelial cell (LEC) membrane damage is one of the pathogenesis of cataract. High mobility group box-1 (HMGB-1) and nuclear factor-κB (NF-κB) play vital roles in a variety of diseases, such as inflammation. Ketamine has numerous pharmacological effects that can inhibit inflammation. Read More

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http://dx.doi.org/10.1080/08923973.2018.1478851DOI Listing
August 2018
17 Reads

Curcumin as a therapeutic agent for blocking NF-κB activation in ulcerative colitis.

Immunopharmacol Immunotoxicol 2018 Dec 15;40(6):476-482. Epub 2018 Aug 15.

d Department of Oncology , Jiangsu Province Hospital of Traditional Chinese Medicine , Nanjing , Jiangsu , China.

Ulcerative colitis (UC) is a chronic, relapsing, remitting, and inflammatory disorder that afflicts millions of people around the world. It carries a substantial economic burden, reducing the quality of life, ability to work, and increasing disability. Conventional medical treatment of UC includes the use of aminosalicylates, corticosteroids, and immunosuppressive drugs. Read More

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http://dx.doi.org/10.1080/08923973.2018.1469145DOI Listing
December 2018
4 Reads