5,965 results match your criteria Immunology Letters [Journal]


Salmonella SPI-2 type III secretion system-dependent inhibition of antigen presentation and T cell function.

Immunol Lett 2019 Feb 13. Epub 2019 Feb 13.

MRC Centre for Molecular Bacteriology and Infection, Imperial College London, SW7 2AZ, UK. Electronic address:

Salmonella enterica serovars infect a broad range of mammalian hosts, including humans, causing both gastrointestinal and systemic diseases. Effective immune responses to Salmonella infections depend largely on CD4 T cell activation by dendritic cells (DCs). Bacteria are internalised by intestinal DCs and respond by translocating effectors of the Salmonella pathogenicity island 2 (SPI-2) type III secretion system (T3SS) into host cells. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.imlet.2019.01.006DOI Listing
February 2019

The role of type I interferons in CD4 T cell differentiation.

Immunol Lett 2019 Feb 13. Epub 2019 Feb 13.

Division of Immunology, Transplantation and Infectious Diseases and Experimental Imaging Center, IRCCS San Raffaele Scientific Institute and Vita-Salute San Raffaele University, Milan, 20132, Italy. Electronic address:

Type I interferons (IFNs) released upon viral infections play different and opposing roles in disease outcome. This pleiotropic effect is mainly influenced by the cellular sources, timing and target cells for these molecules. The effect of type I IFN signaling on the activation and differentiation of antiviral CD4 T cells remains ill defined, with studies reporting either a beneficial or a detrimental role, depending on the context of infection. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.imlet.2019.01.013DOI Listing
February 2019

Monocyte clearance of apoptotic neutrophils is unhindered in the presence of NETosis, but proteins of NET trigger ETosis in monocytes.

Immunol Lett 2019 Feb 7;207:36-45. Epub 2019 Feb 7.

School of Biosciences, Mahatma Gandhi University, Kottayam, 686560 Kerala, India. Electronic address:

Resolution of inflammation needs effective and timely removal of dead cells and other toxic products of neutrophils, monocytes, and macrophages. In this study, we evaluated the role of monocytes in the clearance of neutrophil extracellular trap (NET) and apoptotic neutrophils in the inflammation site. For this, monocytes were observed microscopically after exposing them with NETs and/or apoptotic bodies. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.imlet.2019.02.001DOI Listing
February 2019

Negative regulation of innate lymphoid cell responses in inflammation and cancer.

Immunol Lett 2019 Jan 31. Epub 2019 Jan 31.

Department of Molecular Medicine, Sapienza University of Rome, Laboratory affiliated to Istituto Pasteur Italia - Fondazione Cenci Bolognetti, Rome, Italy; IRCCS Neuromed, 86077, Pozzilli, IS, Italy. Electronic address:

The immune system employs an array of effector cells to ensure tissue homeostasis and protection against pathogens. Lymphocytes belonging to both the adaptive and innate branches share several functions, comprising the ability to directly kill stressed or transformed cells, and to provide helper responses through specific production of cytokines. These properties are regulated by distinct sets of soluble molecules, receptors, and intracellular factors, which altogether tune the functional output of effector lymphocytes and their final activation state. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.imlet.2019.01.011DOI Listing
January 2019

A comparison between adjuvant and delivering functions of calcium phosphate, aluminum hydroxide and chitosan nanoparticles, using a model protein of Brucella melitensis Omp31.

Immunol Lett 2019 Jan 29;207:28-35. Epub 2019 Jan 29.

Nanomedicine and Nanobiology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran; Department of Medical Physics, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran. Electronic address:

Vaccination is the most efficient and economic approach used to hinder infection and intense consequences caused by viruses, bacteria, or other pathogenic organisms. Since the intrinsic immunogenicity of recombinant antigens is usually low, safe and potent vaccine adjuvants are needed to ensure the success of those recombinant vaccines. Nanoparticles (NPs) have attracted much interest as adjuvants and delivery systems. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.imlet.2019.01.010DOI Listing
January 2019

Intact bioactivities and improved pharmacokinetic of the SL335-IFN-β-1a fusion protein that created by genetic fusion of SL335, a human anti-serum albumin fab, and human interferon-β.

Immunol Lett 2019 Jan 23;207:46-55. Epub 2019 Jan 23.

Department of Systems Immunology, Division of Biomedical Convergence, College of Biomedical Science, Kangwon National University, Chuncheon, Gangwon 200-701, South Korea; AprilBio Co., Ltd, Kangwon National University, Rm. A202, Biomedical Science Building, Chuncheon, Gangwon 200-701, South Korea; Institute of Biological Technology, College of Biomedical Science, Kangwon National University, Chuncheon, Gangwon 200-701, South Korea. Electronic address:

Recombinant human interferon beta (rIFN-β) has long been used as a first-line treatment for multiple sclerosis (MS), and any attempt to develop a long-acting rIFN-β is desirable since only one pegylated version of long-acting rIFN-β-1a (Plegridy) is currently available in clinics. Previously, we reported that SL335, a human Fab molecule specific to serum albumin, exhibits an extended serum half-life via utilizing the FcRn recycling mechanism. With the ultimate goal of developing a long-acting rIFN-®, we generated a fusion construct by linking human IFN-β cDNA to the C-terminus of the SL335 H chain at the DNA level followed by expression of the fusion protein, referred to as SL335-IFN-β-1a, in Chinese hamster ovary-S (CHO-S) cells. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.imlet.2019.01.009DOI Listing
January 2019
1 Read

Mouse models of severe asthma for evaluation of therapeutic cytokine targeting.

Immunol Lett 2019 Jan 16. Epub 2019 Jan 16.

Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, Russia; Lomonosov Moscow State University, Moscow, Russia.

Severe asthma is a heterogeneous inflammatory disease of the airways, which requires treatment with high-dose inhaled corticosteroids or their systemic administration, yet often remains uncontrolled despite this therapy. Over the past decades, research efforts into phenotyping of severe asthma and defining the pathological mechanisms of this disease were successful largely due to the development of appropriate animal models. Recent identification of distinct inflammatory patterns of severe asthma endotypes led to novel treatment approaches, including targeting specific cytokines or their receptors with neutralizing antibodies. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.imlet.2018.11.012DOI Listing
January 2019
1 Read

IL-10 T follicular regulatory cells are associated with the pathogenesis of IgG4-related disease.

Immunol Lett 2019 Jan 15;207:56-63. Epub 2019 Jan 15.

Department of Human Immunology, Research Institute for Frontier Medicine, Sapporo Medical University School of Medicine, Chuo-ku, Sapporo 060-8556, Japan.

IgG4-related disease (IgG4-RD) is a chronic fibroinflammatory disease characterized by elevation of serum IgG4 level as well as infiltration of IgG4 plasma cells in various affected organs. The etiology of IgG4-RD is still not fully understood. Since IgG4-RD is more prevalent in the elderly, aging in itself is considered to be an important risk factor of IgG4-RD. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S01652478183036
Publisher Site
http://dx.doi.org/10.1016/j.imlet.2019.01.008DOI Listing
January 2019
7 Reads

Genetic variants of SMAD2/3/4/7 are associated with susceptibility to ulcerative colitis in a Japanese genetic background.

Immunol Lett 2019 Jan 14. Epub 2019 Jan 14.

Department of Pharmacotherapeutics, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1 Sakamoto-machi, Nagasaki 852-8102, Japan.

Purpose: Inflammatory bowel disease (IBD), which includes Crohn's disease (CD) and ulcerative colitis (UC), is attributed to inappropriate inflammatory response in intestinal mucosa. Transforming growth factor β (TGF-β)/SMAD signaling plays key role in differentiation of naïve CD4 T cells to T helper 17 (Th17) cells or regulatory T (T) cells. This study aimed to investigate associations between single nucleotide polymorphisms (SNPs) of SMAD family genes and susceptibility to IBD in a Japanese cohort to elucidate genetic determinants of IBD. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S01652478183053
Publisher Site
http://dx.doi.org/10.1016/j.imlet.2019.01.007DOI Listing
January 2019
4 Reads

Co-expression of membrane-bound TNF-alpha type 1 and 2 receptors differ in the subsets of immunocompetent cells.

Immunol Lett 2019 Jan 11;207:1-5. Epub 2019 Jan 11.

Federal State Budgetary Scientific Institution "Research Institute of Fundamental and Clinical Immunology" (RIFCI), Novosibirsk, Russia.

The immunoregulatory cytokine tumor necrosis factor α plays crucial roles in the pathogenesis of a broad spectrum of disorders. However, its effect may depend on the expression and co-expression of receptors on the target cell. The aim of the present study was to evaluate the expression levels of type 1 and 2 tumor necrosis factor α receptors (TNFR1/2) on individual cell subsets from peripheral blood of healthy volunteers. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.imlet.2019.01.005DOI Listing
January 2019

Corrigendum to "Ro60 inhibits colonic inflammation and fibrosis in a mouse model of dextran sulfate sodium-induced colitis" [Immunol. Lett. 176 (2016) 81-89].

Immunol Lett 2019 Jan 9. Epub 2019 Jan 9.

The Rheumatism Research Center, Catholic Research Institute of Medical Science, The Catholic University of Korea, College of Medicine, Seoul, Republic of Korea; Department of Biomedicine & Health Sciences, College of Medicine, The Catholic University of Korea, 222, Banpo-daero, Seocho-gu, Seoul, 06591, Republic of Korea. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.imlet.2019.01.001DOI Listing
January 2019

Notch signaling induces lymphoproliferation, T helper cell activation and Th1/Th2 differentiation in leprosy.

Immunol Lett 2019 Jan 7;207:6-16. Epub 2019 Jan 7.

National JALMA Institute for Leprosy and Other Mycobacterial Diseases (ICMR), Agra, 282004, India. Electronic address:

The present study evaluates role of Notch1 signaling in the regulation of T cell immunity in leprosy. Peripheral blood mononuclear cells from leprosy patients and healthy controls were activated with Mycobacterium leprae antigens along with activation of Notch1 signaling pathway and then lymphoproliferation was analyzed by lymphocytes transformation test and the expression of Notch1 and its ligands DLL1, Jagged1 and Jagged 2, T cell activation marker and Th1-Th2 cytokines on Th cells in PBMCs of study subjects were analyzed by flow cytometry. Further, these parameters were also analyzed after inhibition of Notch1 signaling pathway. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.imlet.2019.01.003DOI Listing
January 2019
2 Reads

The multifaceted role of Notch signal in regulating T cell fate.

Immunol Lett 2019 Feb 7;206:59-64. Epub 2019 Jan 7.

Virology Section, Regional Medical Research Centre, NE Region, Indian Council of Medical Research, Dibrugarh, Assam, 786001, India. Electronic address:

Notch signaling pathway facilitates important cellular functions of the host. Notch signal is essential for the development of T cells, and the role of Notch in fine tuning of αβ versus γδ T cell lineage commitment is fundamentally different in mice and human. The Notch family of cell surface receptor likewise plays a critical role in regulating T cell activation, and influences T cell response both intrinsically and through the local environment. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.imlet.2019.01.004DOI Listing
February 2019
1 Read

Haptoglobin improves acute phase response and endotoxin tolerance in response to bacterial LPS.

Immunol Lett 2019 Jan 6;207:17-27. Epub 2019 Jan 6.

Department of Microbiology, Osmania University, Hyderabad 500007, Telangana, India. Electronic address:

Sepsis is characterized by delayed acute phase response and lowered immune tolerance in patients. Acute phase serum proteins, like Haptoglobin (Hp), have been associated with increased mortality in bacteria mediated acute lung inflammation and sepsis in neonates. However, it's direct role in modulating the immune response by regulating pro-inflammatory mediators leading to immune tolerant state and if gender affects its expression levels during bacterial infection, especially in blood has not been fully explored. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S01652478183038
Publisher Site
http://dx.doi.org/10.1016/j.imlet.2019.01.002DOI Listing
January 2019
8 Reads

Distinctly regulated functions and mobilization of CD11c-positive cells elicited by TLR3- and IPS-1 signaling in the cornea.

Immunol Lett 2019 Feb 17;206:49-53. Epub 2018 Dec 17.

Department of Frontier Medical Science and Technology for Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto, Japan.

The human ocular surface epithelium expresses TLR3, which recognizes double-stranded (ds) RNA mimicking polyinosine-polycytidylic acid (polyI:C). Its stimulation induces the secretion of the inflammatory cytokines such as interleukin (IL)-6, IL-8, and type I interferon. The cytoplasmic helicase proteins RIG-I and MDA5 are also expressed on the ocular surface. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S01652478183046
Publisher Site
http://dx.doi.org/10.1016/j.imlet.2018.12.004DOI Listing
February 2019
7 Reads

Identification and immune-related analysis of SNPs in Litopenaeus vannamei Toll3 receptor.

Immunol Lett 2019 Feb 11;206:19-27. Epub 2018 Dec 11.

Department of Biology and Guangdong Provincial Key Laboratory of Marine Biotechnology, Shantou University, Shantou, 515063, China. Electronic address:

Tolls and Toll-like receptors (TLRs), as innate immune-recognition receptors that recognize molecular patterns associated with microbial pathogens, play a critical role in antimicrobial immune responses. Here, we report on single nucleotide polymorphisms (SNPs) of Litopenaeus vannamei Toll3 (LvToll3). Multiple sequence alignment of the L. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.imlet.2018.12.002DOI Listing
February 2019
2.512 Impact Factor

A dual role of TGF-β in human osteoclast differentiation mediated by Smad1 versus Smad3 signaling.

Immunol Lett 2019 Feb 10;206:33-40. Epub 2018 Dec 10.

Rheumatology, College of Medicine, Korea University, Seoul, South Korea. Electronic address:

TGF-β1 is highly expressed in the synovial tissue of patients with rheumatoid arthritis and is known as a cytokine that plays an important role in tissue repair and immune cell regulation. However, the role of TGF-β1 is still unclear in osteoclastogenesis. In this study, we examined the effect of TGF-β1 on osteoclast differentiation and the underlying mechanism using healthy human peripheral blood monocytes. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S01652478183042
Publisher Site
http://dx.doi.org/10.1016/j.imlet.2018.12.003DOI Listing
February 2019
3 Reads

Soluble mannose receptor levels in blood correlate to disease severity in patients with community-acquired pneumonia.

Immunol Lett 2019 Feb 4;206:28-32. Epub 2018 Dec 4.

Department of R&D, Hycult Biotechnology, Uden, the Netherlands. Electronic address:

Purpose: Community-acquired pneumonia (CAP) is the most common form of pneumonia and is a leading infectious cause worldwide. Identification of patients that are at risk to develop severe disease has proven to be a major challenge. Soluble mannose receptor (sMR; sCD206) is a new serum marker for macrophage activation. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.imlet.2018.12.001DOI Listing
February 2019
8 Reads

Impact of activated invariant natural killer T cells on the expansion of regulatory T cell precursors in murine thymocytes in vitro.

Immunol Lett 2019 Feb 29;206:41-48. Epub 2018 Nov 29.

Department of Urology, Tokyo Women's Medical University, Kawadacho, Shinjuku-ku, Tokyo, 162-8666, Japan. Electronic address:

Tolerance induction is a goal of clinical transplantation to prevent graft rejection without the lifelong use of immunosuppressive drugs. In a series of mouse studies, we previously reported that the establishment of mixed chimerism by treatment with a ligand for invariant natural killer T (iNKT) cells with CD40 signal blockade makes it possible to prevent allograft rejection without immunosuppressants, and this approach fails in thymectomized recipient mice. In this study, we showed that iNKT cells in murine thymocyte cultures are indispensable for the expansion of CD4CD25Foxp3 regulatory T (Treg) cells as well as CD4CD25Foxp3 cells, which contained precursor Tregs (preTregs). Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S01652478183043
Publisher Site
http://dx.doi.org/10.1016/j.imlet.2018.11.013DOI Listing
February 2019
7 Reads
2.512 Impact Factor

miR-181b regulates ER stress induced neuron death through targeting Heat Shock Protein A5 following intracerebral haemorrhage.

Immunol Lett 2019 Feb 29;206:1-10. Epub 2018 Nov 29.

Department of Neurology, Yongchuan Hospital, Chongqing Medical University, Chongqing, 402160, China. Electronic address:

Endoplasmic reticulum (ER) stress acts as a protein folding and contributes to neuronal damage and neurological deterioration following intracerebral hemorrhage (ICH). Heat Shock Protein A5 (HSPA5) serves as an essential regulator of the endoplasmic reticulum (ER) stress response. However, the specific mechanism has not been will identified. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.imlet.2018.11.014DOI Listing
February 2019
1 Read
2.512 Impact Factor

Interaction and involvement of cellular adhesion molecules in the pathogenesis of Schistosomiasis mansoni.

Immunol Lett 2019 Feb 29;206:11-18. Epub 2018 Nov 29.

Departamento de Análises Clínicas e Toxicológicas, Faculdade de Farmácia, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil. Electronic address:

Parasites from genus Schistosoma currently infect more than 200 million people worldwide. Infection with Schistosoma mansoni causes intestinal schistosomiasis with geographical distribution across Africa, Middle East, Caribbean, Brazil, Venezuela and Suriname. People with Schistosomiasis mansoni suffer from a chronic disease as result of an exacerbated immune response to the eggs deposited in hepatic tissue. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.imlet.2018.11.011DOI Listing
February 2019
2 Reads

Passive immunotherapy with specific IgG fraction against autolysin: Analogous protectivity in the MRSA infection with antibiotic therapy.

Immunol Lett 2018 Nov 26. Epub 2018 Nov 26.

Recombinant Vaccine Research Center, Tehran University of Medical Sciences, Tehran, Iran.

Staphylococcus aureus is a leading infectious cause of life-threatening diseases in human beings, with no effective vaccine available to date against this bacterium. Treatment of methicillin-resistant S. aureus (MRSA) infections has become increasingly difficult because of the emergence of multidrug-resistant isolates. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.imlet.2018.11.010DOI Listing
November 2018

Anti-rheumatoid arthritis effects in adjuvant-induced arthritis in rats and molecular docking studies of Polygonum orientale L. extracts.

Immunol Lett 2018 Sep 22;201:59-69. Epub 2018 Nov 22.

College of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, 611137, China; Guizhou Yibai Pharmaceutical Co., Ltd., Guizhou, 550008, China. Electronic address:

Background And Purpose: Polygonum orientale L. (family: Polygonaceae), named Hongcao in China, has effects of dispelling wind and dampness, promoting blood circulation, and relieving pain. Our group has already studied and confirmed that POEa and POEe (ethyl acetate and ethyl ether extract of P. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.imlet.2018.11.009DOI Listing
September 2018
10 Reads

Impact of the GK-1 adjuvant on peritoneal macrophages gene expression and phagocytosis.

Immunol Lett 2018 Sep 14;201:20-30. Epub 2018 Nov 14.

Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, Av. Universidad 3000, CP 04510, Ciudad de México, Mexico. Electronic address:

Purpose: The synthetic peptide GK-1 potentiates protective immunity elicited by the influenza vaccine in mice. In order to understand its adjuvant properties, this study was designed to determine the impact of GK-1 on gene expression and phagocytosis of peritoneal macrophages (PMa).

Methods: Increased gene expression of chemokines involved in leukocyte recruitment and of pro-inflammatory mediators was detected by microarray analysis of control and GK-1 treated PMa macrophages. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S01652478183021
Publisher Site
http://dx.doi.org/10.1016/j.imlet.2018.10.010DOI Listing
September 2018
13 Reads

Interleukin-33 gene expression and rs1342326 polymorphism in Behçet's disease.

Immunol Lett 2018 Nov 14. Epub 2018 Nov 14.

Connective Tissue Research Center, Tabriz University of Medical Science, Iran; Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran; Drug Applied Research Center, Tabriz University of Medical Sciences, Iran; Department of Immunology, School of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran. Electronic address:

Objective: Behçet's disease (BD) is a chronic multi-factorial inflammatory disease with the important role of genetic in activation of its inflammatory response. Interleukin (IL)-33 is a member of the IL-1 family of cytokines that affects innate and adaptive immune systems to promote inflammatory responses. In the current study, we investigated the association of IL-33 gene rs1342326 polymorphism and expression levels of this gene in peripheral blood mononuclear cells (PBMCs) with the susceptibility to BD in Azari population of Iran. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.imlet.2018.11.005DOI Listing
November 2018
15 Reads
2.512 Impact Factor

Functional insights into nucleotide-metabolizing ectoenzymes expressed by bone marrow-resident cells in patients with multiple myeloma.

Immunol Lett 2018 Nov 15. Epub 2018 Nov 15.

Laboratory of Immunogenetics, Department of Medical Sciences, University of Torino, Italy; CeRMS, University of Torino, Torino, Italy.

Human myeloma cells grow in a hypoxic acidic niche in the bone marrow. Cross talk among cellular components of this closed niche generates extracellular adenosine, which promotes tumor cell survival. This is achieved through the binding of adenosine to purinergic receptors into complexes that function as an autocrine/paracrine signal factor with immune regulatory activities that i) down-regulate the functions of most immune effector cells and ii) enhance the activity of cells that suppress anti-tumor immune responses, thus facilitating the escape of malignant myeloma cells from immune surveillance. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S01652478183048
Publisher Site
http://dx.doi.org/10.1016/j.imlet.2018.11.007DOI Listing
November 2018
8 Reads

Designing a diagnostic kit for Oxalyl CoA Decarboxylase enzyme by ELISA method.

Immunol Lett 2018 Nov 14. Epub 2018 Nov 14.

Department of Biotechnology, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran; Cellular and Molecular Biology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran; Departments of Biotechnology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Electronic address:

Urinary stones are the third most commonly reported urinary tract disease. Kidney stones are one of the most common types of urinary stones that most of them (70-80%) are calcium oxalate. Oxalic acid is highly oxidized organic compounds, which found in dietary and produced by the intestinal microflora. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S01652478183040
Publisher Site
http://dx.doi.org/10.1016/j.imlet.2018.11.008DOI Listing
November 2018
10 Reads

Human natural killer cells and other innate lymphoid cells in cancer: Friends or foes?

Immunol Lett 2018 Sep 12;201:14-19. Epub 2018 Nov 12.

Department of Immunology, IRCCS Bambino Gesù Children's Hospital, Rome, Italy. Electronic address:

Innate lymphoid cells (ILC) including NK cells (cytotoxic) and the recently identified "helper" ILC1, ILC2 and ILC3, play an important role in innate defenses against pathogens. Notably, they mirror analogous T cell subsets, regarding the pattern of cytokine produced, while the timing of their intervention is few hours vs days required for T cell-mediated adaptive responses. On the other hand, the effectiveness of ILC in anti-tumor defenses is controversial. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S01652478183045
Publisher Site
http://dx.doi.org/10.1016/j.imlet.2018.11.004DOI Listing
September 2018
21 Reads

Extracellular nucleotides and nucleosides as signalling molecules.

Immunol Lett 2018 Nov 12. Epub 2018 Nov 12.

Department of Morphology, Surgery and Experimental Medicine, University of Ferrara, Ferarra, Italy. Electronic address:

Extracellular nucleotides, mainly ATP, but also ADP, UTP, UDP and UDP-sugars, adenosine, and adenine base participate in the "purinergic signalling" pathway, an ubiquitous system of cell-to-cell communication. Fundamental pathophysiological processes such as tissue homeostasis, wound healing, neurodegeneration, immunity, inflammation and cancer are modulated by purinergic signalling. Nucleotides can be released from cells via unspecific or specific mechanisms. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S01652478183035
Publisher Site
http://dx.doi.org/10.1016/j.imlet.2018.11.006DOI Listing
November 2018
10 Reads

Cross-talk between signal transduction and metabolism in B cells.

Authors:
Julia Jellusova

Immunol Lett 2018 Sep 12;201:1-13. Epub 2018 Nov 12.

BIOSS Centre for Biological Signalling Studies, Albert-Ludwigs-University of Freiburg, Schänzlestr. 18, 79104, Freiburg, Germany; Department of Molecular Immunology, Institute of Biology III at the Faculty of Biology, Albert-Ludwigs-University of Freiburg, Schänzlestr. 1, 79104, Freiburg, Germany. Electronic address:

Mounting evidence demonstrates that specific metabolic adaptations are needed to support B cell development and differentiation and to enable B cells to thrive in different environments. Mitogen induced activation of intracellular signaling pathways triggers nutrient uptake and metabolic remodeling to meet the cells' current needs. Reciprocally, changes in the metabolic composition of the environment, or in intracellular metabolite levels, can modulate signal transduction and thus shape cell fate and function. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S01652478183043
Publisher Site
http://dx.doi.org/10.1016/j.imlet.2018.11.003DOI Listing
September 2018
6 Reads

Association analysis of ERAP1 gene single nucleotide polymorphism in susceptibility to ankylosing spondylitis in Iranian population.

Immunol Lett 2018 Sep 6;201:52-58. Epub 2018 Nov 6.

Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran; Connective Tissue Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran; Department of Immunology, School of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran. Electronic address:

Background Ankylosing spondylitis (AS) is a debilitating spondyloarthropathy that has been associated with variation in several genes. Human leukocyte antigen (HLA)-B27 constructs an impaired structure, culminating in recognition and activation of immune system. Impaired function of Endoplasmic reticulum aminopeptidase (ERAP) 1, which primes peptides to be loaded in HLA molecules, has strongly been associated with AS proneness. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S01652478183029
Publisher Site
http://dx.doi.org/10.1016/j.imlet.2018.11.002DOI Listing
September 2018
14 Reads
2.512 Impact Factor

Ro60 Inhibits Colonic Inflammation and Fibrosis in a Mouse Model of Dextran Sulfate Sodium-Induced Colitis.

Immunol Lett 2018 Sep 3;201:45-51. Epub 2018 Nov 3.

The Rheumatism Research Center, Catholic Research Institute of Medical Science, The Catholic University of Korea, College of Medicine, Seoul, Republic of Korea; Department of Biomedicine & Health Sciences, College of Medicine, The Catholic University of Korea, 222, Banpo-daero, Seocho-gu, Seoul, 06591, Republic of Korea.

Inflammatory bowel disease (IBD) is caused by chronic inflammation of the gastrointestinal tract. The pathogenesis of IBD remains unclear. The inflammation is associated with activation of T helper (Th) lymphocytes and chronic production of inflammatory cytokines. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.imlet.2018.11.001DOI Listing
September 2018
5 Reads

Anti-inflammatory role of CD11bLy6G neutrophilic cells in allergic airway inflammation in mice.

Immunol Lett 2018 Dec 28;204:67-74. Epub 2018 Oct 28.

Children's Hospital of the University of Tübingen, Pediatric Infectiology, Immunology & Cystic Fibrosis, Hoppe-Seyler-Str. 1, Tübingen, Germany; Department of Pharmacology and Experimental Therapy, Institute of Experimental and Clinical Pharmacology and Toxicology and ICePhA, University of Tübingen, Tübingen, Germany. Electronic address:

Asthma is a chronic inflammatory disease driven by overactivation of T helper cell type 2 (Th2) responses. In the present study, we investigated the functional relevance of CD11bLy6G neutrophilic cells in allergic airway inflammation in vivo. Allergic airway inflammation in mice was induced by house dust mite (HDM) or ovalbumin (OVA) sensitization and challenge. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S01652478183026
Publisher Site
http://dx.doi.org/10.1016/j.imlet.2018.10.007DOI Listing
December 2018
8 Reads

Critical regulation of Th17 cell differentiation by serum amyloid-A signalling in Behcet's disease.

Immunol Lett 2018 Sep 29;201:38-44. Epub 2018 Oct 29.

Department of Emergency and Organ Transplantation, Rheumatology Unit, Bari, Italy.

The current understandings on cellular and molecular biology suggest that Th17 axis plays a pivotal role in Behcet's disease (BD) pathogenesis. Recently the role of serum amyloid-A (SAA) as a potential marker of disease activity in BD patients has been explored, and it has been reported that the occurrence of specific clinical features are significantly associated with high serum levels of this inflammatory mediator. The aim of this study was to investigate the cytokine-like activity of SAA in inducing Th17 differentiation from CD4 + T naive cells in BD. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.imlet.2018.10.013DOI Listing
September 2018
3 Reads

The involvement of multifunctional TGF-β and related cytokines in pathogenesis of endometriosis.

Immunol Lett 2018 Sep 25;201:31-37. Epub 2018 Oct 25.

Department of Immunology and Serology, School of Pharmacy with the Division of Medical Analytics in Sosnowiec, Medical University of Silesia in Katowice, Poland.

Purpose: Transforming growth factor β (TGF-β) is one of the major immune and inflammation factors responsible for regulating cell proliferation, differentiation, angiogenesis, and immune responses. Deregulated TGF-β activity, especially its influence in peritoneal cytokine cross-talk, has been implicated in pathologies of endometriosis. The aim of this study was to determine whether TGF-β could be involved in the pathogenesis of endometriosis. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S01652478183035
Publisher Site
http://dx.doi.org/10.1016/j.imlet.2018.10.011DOI Listing
September 2018
7 Reads

Determination of mir-155 and mir-146a expression rates and its association with expression level of TNF-α and CTLA4 genes in patients with Behcet's disease.

Immunol Lett 2018 Dec 23;204:55-59. Epub 2018 Oct 23.

Connective Tissue Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran. Electronic address:

Introduction: MicroRNAs (miRNAs) are involved in the pathogenesis of inflammatory diseases. MiR-146 and miR-155 emerged as key regulators of the immune response. This study designed to analyze the miR-146a and miR-155 expression in patients with Behcet's disease (BD) and investigated their association with the expression of tumor necrosis factor-alpha (TNF-α) and cytotoxic T lymphocyte associated antigen-4 (CTLA-4) genes. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.imlet.2018.10.012DOI Listing
December 2018
16 Reads

Generation of cancer vaccine immunogens derived from major histocompatibility complex (MHC) class I molecules using variable epitope libraries.

Immunol Lett 2018 Dec 16;204:47-54. Epub 2018 Oct 16.

Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México (UNAM), AP 70228, Cuidad Universitaria, CDMX, 04510, Mexico. Electronic address:

Although various immune checkpoint inhibitors (ICIs), used for the treatment of advanced cancer, showed remarkably durable tumor regression in a subset of patients, there are important limitations in a large group of non-responders, and the generation of novel immunogens capable of inducing protective cellular immune responses is a priority in cancer immunotherapy field. During the last decades, several types of vaccine immunogens have been used in numerous preclinical studies and clinical trials. However, although immunity to tumor Ags can be elicited by most vaccines tested, their clinical efficacy remains modest. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.imlet.2018.10.008DOI Listing
December 2018

Does a carrot a day keep the allergy away?

Immunol Lett 2019 Feb 16;206:54-58. Epub 2018 Oct 16.

The Interuniversity Messerli Research Institute of the University of Veterinary Medicine Vienna, Medical University Vienna and University Vienna, Vienna, Austria; Institute of Pathophysiology and Allergy Research, Center for Pathophysiology, Infectiology and Immunology, Medical University Vienna, Vienna, Austria. Electronic address:

Vitamin A is an important micronutrient, from plants diet taken up as carotenoids, from animal food sources as retinol. Its active metabolite retinoic acid (RA) binds to nuclear hormone receptors, thereby regulating gene transcription programs in various cells. Adequate nutritional intake of vitamin A is essential for pre- and postnatal development, eyesight and reproduction, and it contributes to the maintenance and regulation of the immune system. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.imlet.2018.10.009DOI Listing
February 2019
6 Reads

Pyrogens, a polypeptide produces fever by metabolic changes in hypothalamus: Mechanisms and detections.

Immunol Lett 2018 Dec 15;204:38-46. Epub 2018 Oct 15.

Toxicology Division, Biomedical Technology Wing, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Poojapura, Trivandrum 695 012, Kerala, India. Electronic address:

Fever is one of the cardinal symptoms of onset of an infection or inflammation and is the common clinical indicator for medical consultation in mammalian host worldwide. Simply, fever manifested with elevation of body temperature from normal physiological range represents adaptive response of immune system on challenge with an infectious and non-infectious circumstance. Fever usually initiated in the periphery as a result of interaction of immune cells with exogenous or endogenous pyrogens. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S01652478183033
Publisher Site
http://dx.doi.org/10.1016/j.imlet.2018.10.006DOI Listing
December 2018
6 Reads

Regulatory T cells were recruited by CCL3 to promote cryo-injured muscle repair.

Immunol Lett 2018 Dec 12;204:29-37. Epub 2018 Oct 12.

Biotherapy Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, Henan, China; Cancer Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, Henan, China; School of Life Sciences, Zhengzhou University, Zhengzhou, 450001, Henan, China; Henan Key Laboratory for Tumor Immunology and Biotherapy, Zhengzhou, Henan 450052, China. Electronic address:

Skeletal muscle injury is a common symptom in daily life. After injury, a distinct population of regulatory T cells (Tregs) will infiltrate skeletal muscle in acute and chronic injury sites. However, the mechanism by which Tregs rapidly accumulate to the site of acute injury remains unclear. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S01652478183025
Publisher Site
http://dx.doi.org/10.1016/j.imlet.2018.10.004DOI Listing
December 2018
14 Reads
2.512 Impact Factor

Identification of key genes in Ankylosing spondylitis.

Immunol Lett 2018 Dec 12;204:60-66. Epub 2018 Oct 12.

Department of Orthopaedics, Sandong University Qilu Hospital, China. Electronic address:

Ankylosing spondylitis (AS) is a common form of seronegative spondyloarthritis. We had identified differentially expressed genes (DEGs) in AS based on our previous RNA-sequencing results. Our study aimed to identify key genes in AS by integrated microarray analysis. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S01652478183001
Publisher Site
http://dx.doi.org/10.1016/j.imlet.2018.03.016DOI Listing
December 2018
8 Reads

Genome-wide analysis of gene expression after one year of venom immunotherapy.

Immunol Lett 2018 Dec 10;204:23-28. Epub 2018 Oct 10.

Department of Genetics, Wroclaw Medical University, Wroclaw, Poland.

Background Insect venom immunotherapy (VIT) is used to protect patients against Hymenoptera insects' venom allergy (HVA), which can result in severe systemic or even life-threatening conditions. Molecular mechanisms triggered by VIT remain largely unknown. Objective To compare genome-wide gene expression of patients with severe HVA prior to VIT and 12 months after. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S01652478183033
Publisher Site
http://dx.doi.org/10.1016/j.imlet.2018.10.005DOI Listing
December 2018
12 Reads

Impact of alterations in X-linked IRAK1gene and miR-146a on susceptibility and clinical manifestations in patients with systemic sclerosis.

Immunol Lett 2018 Dec 9;204:1-8. Epub 2018 Oct 9.

Institute of Molecular Genetics and Genetic Engineering, University of Belgrade, Vojvode Stepe 444a, 11000, Belgrade, Serbia. Electronic address:

Systemic sclerosis (SSc) is a heterogeneous multisystem autoimmune disease with unknown etiology. Numerous studies have indicated that the disease heterogeneity implies various genetic abnormalities. Considering that SSc is characterized by a strong sex bias and that the position of IRAK1 gene is on the X chromosome, we assume that variations in IRAK1 gene could explain female predominance of SSc. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.imlet.2018.10.002DOI Listing
December 2018
1 Read

Antigen-presenting cells and T-lymphocytes homing to the thymus shape T cell development.

Immunol Lett 2018 Dec 9;204:9-15. Epub 2018 Oct 9.

Centre de Physiopathologie Toulouse Purpan (CPTP), Université de Toulouse, CNRS, Inserm, UPS, Toulouse, France.

Hematopoietic precursors entering the thymus undergo a maturation process leading to the generation of a variety of T cell subsets that migrate to the periphery to perform their effector functions. This maturation process is strictly regulated by multiple interactions of developing T cells with thymic stroma cells. Signals received via the T cell receptor for antigen, co-stimulatory molecules and cytokines will determine, through thymic selection and lineage choice, thymocyte-fate. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S01652478183031
Publisher Site
http://dx.doi.org/10.1016/j.imlet.2018.10.003DOI Listing
December 2018
4 Reads

Polymorphism of Foxp3 gene affects the frequency of regulatory T cells and disease activity in patients with rheumatoid arthritis in Iranian population.

Immunol Lett 2018 Dec 4;204:16-22. Epub 2018 Oct 4.

Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran; Department of Immunology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran; Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran. Electronic address:

Rheumatoid arthritis (RA) is a chronic autoimmune disease that mainly affects joints and characterized by chronic joint inflammation and infiltration of various immune cells in the synovium. Forkhead box P3 (Foxp3)-expressing regulatory T cells (Tregs) play a crucial role in preventing autoimmunity and undesirable T cell responses. However, there are controversial reports regarding the defective function or frequency of these cells in various studies, which may be in part related to different polymorphisms of FoxP3 and influence of ethnicity on these differences. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S01652478183024
Publisher Site
http://dx.doi.org/10.1016/j.imlet.2018.10.001DOI Listing
December 2018
3 Reads
2.512 Impact Factor

Low-dose multicomponent medication modulates humoral and cellular immune response in an ex-vivo study on children subjected to adenoid surgery.

Immunol Lett 2018 Nov 25;203:95-101. Epub 2018 Sep 25.

Department of Pediatrics, University of Parma, Parma, Italy.

Respiratory infections, mainly in children, are a demanding challenge for physicians. Commonly, a relative immune-defect sustains their recurrence. At present, there is no standardized treatment for their prevention acting on the immune system. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.imlet.2018.09.014DOI Listing
November 2018
1 Read

Opinion: Virtual memory CD8 T cells and lymphopenia-induced memory CD8 T cells represent a single subset: Homeostatic memory T cells.

Immunol Lett 2018 Nov 20;203:57-61. Epub 2018 Sep 20.

Laboratory of Adaptive Immunity, Institute of Molecular Genetics of the Czech Academy of Sciences, Prague, Czech Republic. Electronic address:

It is well established that lymphopenia induces the formation of the memory-phenotype T cells without the exposure to foreign antigens. More recently, the memory-phenotype antigen-inexperienced memory T cells were described in lymphoreplete mice and called virtual memory T cells. In this review, we compare multiple aspects of the biology of lymphopenia-induced memory T cells and virtual memory T cells, including cytokine requirements, the role of T-cell receptor specificity in the differentiation process, gene expression signature, and the immune response. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S01652478183025
Publisher Site
http://dx.doi.org/10.1016/j.imlet.2018.09.003DOI Listing
November 2018
1 Read

Cucurbitacin E ameliorates acute graft-versus-host disease by modulating Th17 cell subsets and inhibiting STAT3 activation.

Immunol Lett 2018 Nov 18;203:62-69. Epub 2018 Sep 18.

The Rheumatism Research Center, Catholic Research Institute of Medical Science, The Catholic University of Korea, College of Medicine, Seoul, South Korea; Department of Biomedicine & Health Sciences, College of Medicine, The Catholic University of Korea, Seoul, South Korea. Electronic address:

Cucurbitacin E (CuE) is a biochemical compound found in plants that are members of the family CuE has been studied for its roles in anti-inflammation and the inhibition of angiogenesis as well as for its properties as an antioxidant. CuE is a new agent that was identified as a selective inhibitor of the signal transducer and activator of transcription 3 (STAT3)-related pathway. STAT3, a pivotal transcription factor for Th17 differentiation, is critical for T cell alloactivation in acute graft-versus-host disease (aGvHD). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.imlet.2018.09.012DOI Listing
November 2018
3 Reads

Increased levels of soluble co-stimulatory molecule PD-L1 (B7-H1) in the plasma of viraemic HIV-1 individuals.

Immunol Lett 2018 Nov 17;203:70-79. Epub 2018 Sep 17.

Departamento de Investigación en Enfermedades Infecciosas, Instituto Nacional de Enfermedades Respiratorias, "Ismael Cosío Villegas", Ciudad de Mexico, Mexico. Electronic address:

Recent evidence has revealed that PD-L1 is expressed in two functional forms, namely, a membrane-bound form (mPD-L1) and a soluble form (sPD-L1). The identification of the soluble form of PD-L1 represents the discovery of a new potential mechanism for the activation of the PD-1 pathway that may mediate a physiological apoptotic mechanism through a cell-cell signalling-independent pathway and may also favour T cell dysfunction during HIV infection. Since the presence of sPD-L1 has not been well established in the scenario of chronic viral infection, we investigated the presence of sPD-L1 in the plasma of viraemic HIV individuals and the potential mechanism that promotes its production. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.imlet.2018.09.007DOI Listing
November 2018

Carbon monoxide ameliorates Staphylococcus aureus-elicited COX-2/IL-6/MMP-9-dependent human aortic endothelial cell migration and inflammatory responses.

Immunol Lett 2018 Nov 17;203:40-49. Epub 2018 Sep 17.

Department of Medical Research, Taichung Veterans General Hospital, Taichung, Taiwan; Department of Nursing, College of Nursing, Hungkuang University, Taichung, Taiwan. Electronic address:

Staphylococcus aureus (S. aureus) can often lead to many life-threatening diseases. It has the ability to invade normal endovascular tissue. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.imlet.2018.09.010DOI Listing
November 2018
14 Reads