5,993 results match your criteria Immunology Letters [Journal]


In vivo deuterium labelling in mice supports a dynamic model for memory T-cell maintenance in the bone marrow.

Immunol Lett 2019 Apr 17. Epub 2019 Apr 17.

Laboratory of Translational Immunology, University Medical Center Utrecht, the Netherlands. Electronic address:

The maintenance and dynamics of memory T-cells in the bone marrow are a matter of ongoing debate. It has been suggested that memory T-cells in the bone marrow are maintained as long-lived, quiescent cells. We have recently shown that memory T-cells isolated from goat bone marrow undergo self-renewal and recirculate via the blood and lymph. Read More

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http://dx.doi.org/10.1016/j.imlet.2019.04.004DOI Listing

Inhibiting phosphatase SHIP-1 enhances suboptimal IgE-mediated activation of human blood basophils but inhibits IgE-mediated activation of cultured human mast cells.

Immunol Lett 2019 Apr 17. Epub 2019 Apr 17.

Department of Clinical Medicine, Aarhus University, Denmark. Electronic address:

IgE-mediated activation of basophil granulocytes and mast cells follows a bell-shaped dose-response curve. The decreased activation at supraoptimal allergen stimulation is thought to be associated with SH2-containing inositol-5'-phosphatase 1 (SHIP-1). SHIP-1 phosphorylation is inversely related to IgE-mediated releasability of basophils. Read More

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http://dx.doi.org/10.1016/j.imlet.2019.04.003DOI Listing

Analysis of interleukin-17 and interleukin-23 for estimating disease activity and predicting the response to treatment in active lupus nephritis patients.

Immunol Lett 2019 Apr 17. Epub 2019 Apr 17.

Department of Infectious Diseases, the 900(th) Hospital of the PLA of China, No.156 North Road West 2nd Ring Road Fuzhou, 350013, China; Clinical educational Institute of the 900(th) Hospital of the PLA affiliated Fujian Medical University, Fuzhou, China. Electronic address:

Renal biopsy is a "gold standard" for establishing the diagnosis and assessing prognosis and monitoring therapy in lupus nephritis (LN) patients, but it is an invasive and inconvenient procedure. Evidences showed that interleukin-17(IL-17) and interleukin-23(IL-23) may be as alternative biomarkers for diagnosing LN, monitoring LN activity and predicting the response to treatment of LN. To analyze the roles of IL-17 and IL-23 in evaluation activity of LN and predicting active LN response to immunosuppressive treatment, by comparison between IL-17, IL-23 and clinical data of LN. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01652478183043
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http://dx.doi.org/10.1016/j.imlet.2019.04.002DOI Listing
April 2019
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Leishmania infantum LeIF and its recombinant polypeptides induce the maturation of dendritic cells in vitro: an insight for dendritic cells based vaccine.

Immunol Lett 2019 Apr 15. Epub 2019 Apr 15.

Laboratory of Molecular Epidemiology and Experimental Pathology, Institut Pasteur de Tunis, Université Tunis El Manar, 13 Place Pasteur, BP 74, 1002 Tunis-Belvedère, Tunisia. Electronic address:

We previously showed that recombinant Leishmania infantum eukaryotic initiation factor (LieIF) was able to induce the secretion of cytokines IL-12, IL-10 and TNF-α by human monocytes. In this study, we explored in vitro the potential of LieIF to induce phenotypic maturation and functional differentiation of murine bone - marrow derived dendritic cells (BM-DCs). Moreover, in order to identify potential immunnomodulatory regions of LieIF, eight recombinant overlapping protein fragments covering the whole amino acid sequence ofprotein; were constructed and assessed in vitro for their ability to induce maturation of BM-DCs. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01652478183041
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http://dx.doi.org/10.1016/j.imlet.2019.04.001DOI Listing
April 2019
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Allergy to Mus m 1: Allergy to Mus m 1: A review of structural, and immunological features.

Immunol Lett 2019 Apr 9;209:1-3. Epub 2019 Apr 9.

Medical Research Group (GINUMED) Universitary Corporation Rafael Nuñez, Colombia.

The prevalence of allergies to pets has been increasing over the past decades. Some of the most important animal-derived allergens are members of the lipocalin protein family, which are found in dander, saliva, and urine. These allergens disperse effectively and are widely present in indoor environments. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01652478193005
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http://dx.doi.org/10.1016/j.imlet.2019.03.012DOI Listing
April 2019
2 Reads

Differential effects of anaphylatoxin C5a on antigen presenting cells, roles for C5aR1 and C5aR2.

Immunol Lett 2019 Apr 5;209:45-52. Epub 2019 Apr 5.

Department of Immunopathology, Sanquin Research, Amsterdam, the Netherlands and Landsteiner Laboratory, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands. Electronic address:

The anaphylatoxin C5a is well-known for its role as chemoattractant and contributes to immune cell recruitment into inflamed tissue and local inflammation. C5a has recently been implicated in modulation of antigen presenting cell function, such as macrophages and dendritic cells, which are pivotal for T cell activation and final T cell effector function. The published data on the effect of C5a on APC function and subsequent adaptive immune responses are in part conflicting, as both pro and anti-inflammatory effects have been described. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01652478193007
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http://dx.doi.org/10.1016/j.imlet.2019.03.014DOI Listing
April 2019
2 Reads

Mechanisms of polarized cell-cell communication of T lymphocytes.

Immunol Lett 2019 Apr 5;209:11-20. Epub 2019 Apr 5.

Servicio de Inmunología, Hospital Universitario de la Princesa, UAM, IIS-IP, 28006 Madrid, Spain; Area of Vascular Pathophysiology, Laboratory of Intercellular Communication Fundación Centro Nacional de Investigaciones Cardiovasculares-Carlos III, 28029 Madrid, Spain; Centro de Investigación Biomédica en Red de Enfermedades Cardiovasculares (CIBERCV), 28029 Madrid, Spain. Electronic address:

Cell-cell communication comprises a variety of molecular mechanisms that immune cells use to respond appropriately to diverse pathogenic stimuli. T lymphocytes polarize in response to different stimuli, such as cytokines, adhesion to specific ligands and cognate antigens presented in the context of MHC. Polarization takes different shapes, from migratory front-back polarization to the formation of immune synapses (IS). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01652478193010
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http://dx.doi.org/10.1016/j.imlet.2019.03.009DOI Listing
April 2019
1 Read

Effector memory regulatory T cells were most effective at suppressing RANKL but their frequency was downregulated in tibial fracture patients with delayed union.

Immunol Lett 2019 Apr 1;209:21-27. Epub 2019 Apr 1.

Department of Orthopedics, Jinling School of Clinical Medicine, Nanjing Medical University, Jinling Hospital, Nanjing, 210002, Jiangsu Province, China. Electronic address:

Delayed union and nonunion occur in a minor subject of bone fractures, presenting ongoing challenges to treatment. RANKL, which promotes the differentiation of bone-resorbing osteoclasts, is thought to negatively impact bone healing. In this study, we recruited patients with isolated closed tibial fracture, who were later categorized into normal healing and delayed healing groups based on their healing progression. Read More

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http://dx.doi.org/10.1016/j.imlet.2019.03.018DOI Listing
April 2019
2 Reads

The molecular and clinical evidence of vitamin D signaling as a modulator of the immune system: Role in Behçet's disease.

Immunol Lett 2019 Mar 29;210:10-19. Epub 2019 Mar 29.

Connective Tissue Diseases Research Center, Tabriz University of Medical Science, Tabriz, Iran. Electronic address:

Various tissues and cell types are the targets of vitamin D. However, the major targets of vitamin D in the immune system are monocytes/macrophages, dendritic cells (DCs), as well as B and T cells. Vitamin D plays an important role in the immune system modulation via regulating the expression of genes that generate pro-inflammatory mediators and inhibiting the proliferation of pro-inflammatory cells, both of which have been implicated in the pathophysiology of the inflammatory diseases. Read More

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http://dx.doi.org/10.1016/j.imlet.2019.03.017DOI Listing
March 2019
2.512 Impact Factor

The role of ocular dendritic cells in uveitis.

Immunol Lett 2019 Mar 26;209:4-10. Epub 2019 Mar 26.

Eye Institute of Shandong University of Traditional Chinese Medicine, Jinan, 250002, China. Electronic address:

Dendritic cells (DCs) act as a bridge between innate and adoptive immunity. They are widely distributed in various tissues and organs. Resident ocular DCs are found in the peripheral margins and juxtapapillary areas of the retina, usually in an immature state. Read More

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http://dx.doi.org/10.1016/j.imlet.2019.03.016DOI Listing

Role of plasminogen activator inhibitor - 1 (PAI-1) in regulating the pathogenesis of S. aureus arthritis via plasminogen pathway.

Immunol Lett 2019 Mar 25;209:53-66. Epub 2019 Mar 25.

Department of Physiology, Immunology and Microbiology Laboratory, University of Calcutta, University Colleges of Science and Technology, 92 APC Road, Calcutta, 700 009, West Bengal, India. Electronic address:

uPA/tPA-mediated activation of plasminogen/plasmin pathway during S. aureus arthritis facilitates the invasion of phagocytes in the affected joint, induces production of cytokines and triggers inflammatory pathways. PAI-1, an effective inhibitor of both uPA and tPA, attenuates plasmin activity. Read More

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http://dx.doi.org/10.1016/j.imlet.2019.03.015DOI Listing

TNFR2 but not TNFR1 is the main TNFR expressed by B and T lymphocytes in breast cancer draining lymph nodes.

Immunol Lett 2019 Mar 22;209:36-44. Epub 2019 Mar 22.

Shiraz Institute for Cancer Research, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran. Electronic address:

Tumor necrosis factor-α (TNF-α) is a key cytokine in inflammation and a driving force for leukocyte migration and recruitment. However, it may exert contrasting effects on the immune responses depend on its differential binding to its receptors (TNFR1 or TNFR2). The expression of TNF receptors by lymphocytes in the tumor draining lymph nodes (TDLNs) has not been thoroughly investigated. Read More

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http://dx.doi.org/10.1016/j.imlet.2019.03.013DOI Listing

The repertoire features of T cell receptor β-chain of different age and gender groups in healthy Chinese individuals.

Immunol Lett 2019 Apr 21;208:44-51. Epub 2019 Mar 21.

Biotherapy Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China; School of Life Sciences, Zhengzhou University, Zhengzhou, China. Electronic address:

T cell immunity is dependent on T cell receptor (TCR) recognition of large numbers of antigenic peptides presented in the context of major histocompatibility complex (MHC) class I and II molecules. To explore whether the TCR β-chain repertoire changes with different ages and genders in healthy Chinese individuals, we analyzed the TCR β-chain repertoire in 154 healthy Chinese individuals by High-throughput sequencing (HTS) with age (age range: 6-70) and each age group contains about 20 individuals (male and female). Here we report that the extent of TCR diversity was not dependent on gender but it was significantly different between age groups. Read More

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http://dx.doi.org/10.1016/j.imlet.2019.03.007DOI Listing
April 2019
1 Read
2.512 Impact Factor

Mast cells: A double-edged sword in cancer.

Immunol Lett 2019 Mar 21;209:28-35. Epub 2019 Mar 21.

Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran. Electronic address:

Mast cells (MCs), a type of innate immune cells, are derived from myeloid stem cells, sometimes known as mastocytes or labrocytes, and contain many granules rich in histamine and heparin. The mentioned cells are able to release various mediators such as cytokines, leukotrienes, and a large number of proteases into the environment. Many studies and experiments have established the infiltration of MCs into the tumor site. Read More

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http://dx.doi.org/10.1016/j.imlet.2019.03.011DOI Listing
March 2019
2 Reads

Tuft cells: From the mucosa to the thymus.

Immunol Lett 2019 Mar 21;210:1-9. Epub 2019 Mar 21.

Department of Immunology, Weizmann Institute of Science, Rehovot 76100, Israel. Electronic address:

Tuft cells are epithelial chemosensory cells with unique morphological and molecular characteristics, the most noticeable of which is a tuft of long and thick microvilli on their apical side, as well as expression of a very distinct set of genes, including genes encoding various members of the taste transduction machinery and pro-inflammatory cyclooxygenases. Initially discovered in rat trachea, tuft cells were gradually identified in various mucosal tissues, and later also in non-mucosal tissues, most recent of which is the thymus. Although tuft cells were discovered more than 60 years ago, their functions in the various tissues remained a mystery until recent years. Read More

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http://dx.doi.org/10.1016/j.imlet.2019.02.003DOI Listing

Gene variants in the NF-KB pathway (NFKB1, NFKBIA, NFKBIZ) and risk for early-onset coronary artery disease.

Immunol Lett 2019 Apr 19;208:39-43. Epub 2019 Mar 19.

Genética Molecular, Hospital Universitario Central Asturias, Oviedo, Spain.

The nuclear-factor kappa-beta (NF-KB) is a driver of inflammation, and plays an important role in the pathogenesis of atherosclerosis and coronary artery disease (CAD). Early-onset CAD is defined as a coronary ischaemic episode at an age ≤55 years, and in our population was strongly associated with male sex and smoking. Our aim was to determine whether common variants in three NF-KB genes were associated with early-onset CAD. Read More

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http://dx.doi.org/10.1016/j.imlet.2019.02.007DOI Listing

Exploration of some new secretory proteins to be employed for companion diagnosis of Mycobacterium tuberculosis.

Immunol Lett 2019 Mar 18. Epub 2019 Mar 18.

Department of Microbiology, CSIR-Central Drug Research Institute, Lucknow, 226031, India. Electronic address:

Tuberculosis (TB) is a highly infectious disease and its early and precise diagnosis is essential to reduce morbidity and mortality of patients. Since the routine diagnostic tests (like Monteux, AFB smear microscopy, chest X-Ray) do not give infallible results, additional tests are always recommended. Therefore to address the concerns about non-specificity of the present battery of diagnostic tests, we have attempted to analyze some unique secretory antigens which could be able to identify the stage specific infection of MTB. Read More

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http://dx.doi.org/10.1016/j.imlet.2019.03.010DOI Listing

Targeting the tumor microenvironment to overcome immune checkpoint blockade therapy resistance.

Immunol Lett 2019 Mar 15. Epub 2019 Mar 15.

Center of Systems Medicine, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100005, Suzhou Institute of Systems Medicine, Suzhou, Jiangsu, China. Electronic address:

The ability of immune checkpoint inhibitors (ICIs) to reactivate the killing function of the immune system to tumor cells has led to long lasting immune response presenting highly promising clinical advances. Recently, immune checkpoint inhibitors related resistance due to the specialized tumor microenvironment has also drawn a widely attention. To overcome resistance to immune checkpoint blockade therapy, understanding the relationship of this type of therapy and tumor microenvironment is necessary and critical. Read More

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http://dx.doi.org/10.1016/j.imlet.2019.03.006DOI Listing
March 2019
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Identification of a neoantigen epitope in a melanoma patient with good response to anti-PD-1 antibody therapy.

Immunol Lett 2019 Apr 14;208:52-59. Epub 2019 Mar 14.

Immunotherapy Division, Shizuoka Cancer Center Research Institute, 1007 Shimonagakubo, Nagaizumi-cho, Sunto-gun, Shizuoka 411-8777, Japan. Electronic address:

Recent advances in next-generation sequencing have enabled rapid and efficient evaluation of the mutational landscape of cancers. As a result, many cancer-specific neoantigens, which can generate antitumor cytotoxic T-cells inside tumors, have been identified. Previously, we reported a metastatic melanoma case with high tumor mutation burden, who obtained complete remission after anti-PD-1 therapy and surgical resection. Read More

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http://dx.doi.org/10.1016/j.imlet.2019.02.004DOI Listing

The adaptive immune and stress responses of adult female CD1 mice following exposure to a viral mimetic.

Immunol Lett 2019 Apr 14;208:30-38. Epub 2019 Mar 14.

School of Psychology, Faculty of Social Sciences, University of Ottawa, Canada. Electronic address:

Exposure to a bacterial endotoxin during puberty induces long-term changes to reproductive and non-reproductive behaviours. While the underlying mechanisms remain unknown, we have recently shown that there are age and sex differences in acute immune and stress responses following immune challenge. Given that it is unclear whether viral infections result in similar age and sex differences, the objective of this study was to examine the acute immune and stress responses following exposure to polyinosinic:polycytidylic acid (poly(I:C)), a viral mimetic, in CD1 mice and to investigate the role of gonadal hormones in these responses. Read More

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http://dx.doi.org/10.1016/j.imlet.2019.03.005DOI Listing

Interactions between cancer stem cells, immune system and some environmental components: Friends or foes?

Immunol Lett 2019 Apr 9;208:19-29. Epub 2019 Mar 9.

Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran. Electronic address:

Cancer stem cells (CSCs) are a subgroup of tumor cells that are characterized by their tumor initiating capacity, low proliferation rate, self-renewal capacity, pluripotency and chemoresistance. The immune system, including innate and adaptive immune cells, plays pro-tumorigenic and anti-tumorigenic roles in cancer biology. Immunosurveillance often initially successfully eradicates tumor cells. Read More

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http://dx.doi.org/10.1016/j.imlet.2019.03.004DOI Listing

Medullary thymic epithelial cells: Deciphering the functional diversity beyond promiscuous gene expression.

Immunol Lett 2019 Mar 7. Epub 2019 Mar 7.

i3S - Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Portugal; IBMC - Instituto de Biologia Molecular e Celular, Universidade do Porto, Portugal. Electronic address:

Within the thymus, cortical and medullary thymic epithelial cells (cTECs and mTECs, respectively) provide unique microenvironments for the development of T cells that are responsive to diverse foreign antigens while self-tolerant. Essential for tolerance induction, mTECs play a critical role in negative selection and T regulatory cell differentiation. In this article, we review the current knowledge on the functional diversity within mTECs and discuss how these novel subsets contribute to tolerance induction and are integrated in the complex blueprint of mTEC differentiation. Read More

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http://dx.doi.org/10.1016/j.imlet.2019.01.012DOI Listing

Circulating CXCR3-CCR6-CXCR5CD4 T cells are associated with acute allograft rejection in liver transplantation.

Immunol Lett 2019 Mar 5. Epub 2019 Mar 5.

Treatment and Research Center for Infectious Disease, Beijing 302 Hospital, Beijing, China. Electronic address:

Circulating T follicular helper (cTFH) cells have been demonstrated to be involved in B-cell-mediated alloreactive responses in kidney and liver transplantation; however, whether these cells are involved in acute liver allograft rejection after liver transplantation, and which subsets are involved, remains to be clarified. The present study aimed to investigate the profiles of cTFH cells in acute liver allograft rejection, including the C-X-C motif receptor 3 (CXCR3) chemokine receptor 6 (CCR6)- subset, the CXCR3-CCR6- subset, and the CXCR3-CCR6 subset. Twelve liver transplant patients with acute rejection (AR) and 20 with no acute rejection (NAR) were enrolled in the study. Read More

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http://dx.doi.org/10.1016/j.imlet.2019.03.003DOI Listing
March 2019
2 Reads

Antinuclear antibodies in patients with cervical lesions and invasive cervical cancer.

Immunol Lett 2019 Apr 5;208:8-10. Epub 2019 Mar 5.

Evangelical Mackenzie University, Medicine Department, Curitiba, Brazil; Immunopathology Laboratory, Clinical Hospital, Federal University of Paraná, Curitiba,Brazil; Positivo University, Medicine Department, Curitiba, Brazil. Electronic address:

Background: Antinuclear antibodies (ANA) have been found in several types of cancer although the meaning of its presence is not completely known.

Aim: To study the prevalence of ANA in patients with cervical intraepithelial lesion and invasive cervical cancer.

Methods: A total of 205 women who underwent screening for cervical cancer or treatment at the Erasto Gaertner Cancer Hospital in Curitiba - Brazil, were enrolled in the study. Read More

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http://dx.doi.org/10.1016/j.imlet.2019.03.002DOI Listing
April 2019
2 Reads

Impact of B cell/lymphoid stromal cell crosstalk in B-cell physiology and malignancy.

Immunol Lett 2019 Mar 4. Epub 2019 Mar 4.

UMR_S 1236, Université Rennes 1, INSERM, Etablissement Français du Sang, F-35000, Rennes, France; SITI, Pôle de Biologie, CHU Pontchaillou, F-35000, Rennes, France. Electronic address:

Stromal cells have been considered for a long time essentially as a structural component organizing tissue architecture, including those of secondary lymphoid organs. More recently, highly specialized stromal cell subsets were shown to differentially organize immune cell recruitment, survival, and differentiation within lymph nodes. In particular, mature B cells interact with different lymphoid stromal cell networks through bidirectional interactions involving cell-cell contact and soluble factors. Read More

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http://dx.doi.org/10.1016/j.imlet.2019.02.005DOI Listing
March 2019
4 Reads

Inflammasomes and their roles in the pathogenesis of viral hepatitis and their related complications: An updated systematic review.

Immunol Lett 2019 Apr 1;208:11-18. Epub 2019 Mar 1.

Infectious Diseases Research Center, Aja University of Medical Sciences, Tehran, Iran; Department of Immunology, Medical School, Aja University of Medical Sciences, Tehran, Iran. Electronic address:

Inflammasomes are a set of innate receptors which are the responsible molecules for activation of pro-interleukin (IL)-1β and IL-18 and induction of inflammation. Due to the key roles of the inflammasomes in the induction of inflammation, it has been hypothesized that the molecules may be the main parts of immune responses against viral infections and the tissue damage. Because some cases of viral hepatitis infections, including hepatitis B and C, are diagnosed as chronic and may be associated with various complications such as liver cirrhosis and hepatocellular carcinoma (HCC), several studies focused on the roles played by the inflammation on the pathogenesis of viral hepatitis. Read More

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http://dx.doi.org/10.1016/j.imlet.2019.03.001DOI Listing
April 2019
3 Reads

Reprint of "Immunomodulatory effects of CD38-targeting antibodies".

Immunol Lett 2019 Jan 28;205:71-77. Epub 2019 Feb 28.

Department of Hematology, VU University Medical Center, De Boelelaan 1117, 1081HV Amsterdam, The Netherlands. Electronic address:

The fist in class CD38-targeting antibody, daratumumab, is currently approved as single agent and in combination with standards of care for the treatment of relapsed and refractory multiple myeloma. Based on the high activity and favorable toxicity profile of daratumumab, other CD38 antibodies, such as isatuximab, MOR202, and TAK-079, are being evaluated in MM and other malignancies. The CD38-targeting antibodies have classic Fc-dependent immune effector mechanisms, including antibody-dependent cellular cytotoxicity (ADCC), antibody-dependent cellular phagocytosis (ADCP), and complement-dependent cytotoxicity (CDC). Read More

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http://dx.doi.org/10.1016/j.imlet.2019.02.002DOI Listing
January 2019
3 Reads

Prolongation of skin graft survival in mice by an azaphenothiazine derivative.

Immunol Lett 2019 Apr 27;208:1-7. Epub 2019 Feb 27.

The Medical University of Silesia, School of Pharmacy with the Division of Laboratory Medicine, Department of Organic Chemistry, Jagiellońska 4 Str, 41-200, Sosnowiec, Poland.

Azaphenothiazines are predominantly immunosuppressive compounds. We evaluated the efficacy of an azaphenothiazine derivative, 6-chloroethylureidoethyldiquino[3,2-b;2',3'-e][1,4]thiazine (DQT) in prolongation of survival of skin allografts between BALB/c and C57Bl/6 mice. The mice were treated intraperitoneally (i. Read More

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http://dx.doi.org/10.1016/j.imlet.2019.02.006DOI Listing
April 2019
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Salmonella SPI-2 type III secretion system-dependent inhibition of antigen presentation and T cell function.

Immunol Lett 2019 Feb 13. Epub 2019 Feb 13.

MRC Centre for Molecular Bacteriology and Infection, Imperial College London, SW7 2AZ, UK. Electronic address:

Salmonella enterica serovars infect a broad range of mammalian hosts, including humans, causing both gastrointestinal and systemic diseases. Effective immune responses to Salmonella infections depend largely on CD4 T cell activation by dendritic cells (DCs). Bacteria are internalised by intestinal DCs and respond by translocating effectors of the Salmonella pathogenicity island 2 (SPI-2) type III secretion system (T3SS) into host cells. Read More

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http://dx.doi.org/10.1016/j.imlet.2019.01.006DOI Listing
February 2019

The role of type I interferons in CD4 T cell differentiation.

Immunol Lett 2019 Feb 13. Epub 2019 Feb 13.

Division of Immunology, Transplantation and Infectious Diseases and Experimental Imaging Center, IRCCS San Raffaele Scientific Institute and Vita-Salute San Raffaele University, Milan, 20132, Italy. Electronic address:

Type I interferons (IFNs) released upon viral infections play different and opposing roles in disease outcome. This pleiotropic effect is mainly influenced by the cellular sources, timing and target cells for these molecules. The effect of type I IFN signaling on the activation and differentiation of antiviral CD4 T cells remains ill defined, with studies reporting either a beneficial or a detrimental role, depending on the context of infection. Read More

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http://dx.doi.org/10.1016/j.imlet.2019.01.013DOI Listing
February 2019

Monocyte clearance of apoptotic neutrophils is unhindered in the presence of NETosis, but proteins of NET trigger ETosis in monocytes.

Immunol Lett 2019 Mar 7;207:36-45. Epub 2019 Feb 7.

School of Biosciences, Mahatma Gandhi University, Kottayam, 686560 Kerala, India. Electronic address:

Resolution of inflammation needs effective and timely removal of dead cells and other toxic products of neutrophils, monocytes, and macrophages. In this study, we evaluated the role of monocytes in the clearance of neutrophil extracellular trap (NET) and apoptotic neutrophils in the inflammation site. For this, monocytes were observed microscopically after exposing them with NETs and/or apoptotic bodies. Read More

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http://dx.doi.org/10.1016/j.imlet.2019.02.001DOI Listing

Negative regulation of innate lymphoid cell responses in inflammation and cancer.

Immunol Lett 2019 Jan 31. Epub 2019 Jan 31.

Department of Molecular Medicine, Sapienza University of Rome, Laboratory affiliated to Istituto Pasteur Italia - Fondazione Cenci Bolognetti, Rome, Italy; IRCCS Neuromed, 86077, Pozzilli, IS, Italy. Electronic address:

The immune system employs an array of effector cells to ensure tissue homeostasis and protection against pathogens. Lymphocytes belonging to both the adaptive and innate branches share several functions, comprising the ability to directly kill stressed or transformed cells, and to provide helper responses through specific production of cytokines. These properties are regulated by distinct sets of soluble molecules, receptors, and intracellular factors, which altogether tune the functional output of effector lymphocytes and their final activation state. Read More

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http://dx.doi.org/10.1016/j.imlet.2019.01.011DOI Listing
January 2019

A comparison between adjuvant and delivering functions of calcium phosphate, aluminum hydroxide and chitosan nanoparticles, using a model protein of Brucella melitensis Omp31.

Immunol Lett 2019 Mar 29;207:28-35. Epub 2019 Jan 29.

Nanomedicine and Nanobiology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran; Department of Medical Physics, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran. Electronic address:

Vaccination is the most efficient and economic approach used to hinder infection and intense consequences caused by viruses, bacteria, or other pathogenic organisms. Since the intrinsic immunogenicity of recombinant antigens is usually low, safe and potent vaccine adjuvants are needed to ensure the success of those recombinant vaccines. Nanoparticles (NPs) have attracted much interest as adjuvants and delivery systems. Read More

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http://dx.doi.org/10.1016/j.imlet.2019.01.010DOI Listing

Intact bioactivities and improved pharmacokinetic of the SL335-IFN-β-1a fusion protein that created by genetic fusion of SL335, a human anti-serum albumin fab, and human interferon-β.

Immunol Lett 2019 Mar 23;207:46-55. Epub 2019 Jan 23.

Department of Systems Immunology, Division of Biomedical Convergence, College of Biomedical Science, Kangwon National University, Chuncheon, Gangwon 200-701, South Korea; AprilBio Co., Ltd, Kangwon National University, Rm. A202, Biomedical Science Building, Chuncheon, Gangwon 200-701, South Korea; Institute of Biological Technology, College of Biomedical Science, Kangwon National University, Chuncheon, Gangwon 200-701, South Korea. Electronic address:

Recombinant human interferon beta (rIFN-β) has long been used as a first-line treatment for multiple sclerosis (MS), and any attempt to develop a long-acting rIFN-β is desirable since only one pegylated version of long-acting rIFN-β-1a (Plegridy) is currently available in clinics. Previously, we reported that SL335, a human Fab molecule specific to serum albumin, exhibits an extended serum half-life via utilizing the FcRn recycling mechanism. With the ultimate goal of developing a long-acting rIFN-®, we generated a fusion construct by linking human IFN-β cDNA to the C-terminus of the SL335 H chain at the DNA level followed by expression of the fusion protein, referred to as SL335-IFN-β-1a, in Chinese hamster ovary-S (CHO-S) cells. Read More

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http://dx.doi.org/10.1016/j.imlet.2019.01.009DOI Listing
March 2019
2 Reads

Mouse models of severe asthma for evaluation of therapeutic cytokine targeting.

Immunol Lett 2019 Mar 16;207:73-83. Epub 2019 Jan 16.

Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, Russia; Lomonosov Moscow State University, Moscow, Russia. Electronic address:

Severe asthma is a heterogeneous inflammatory disease of the airways, which requires treatment with high-dose inhaled corticosteroids or their systemic administration, yet often remains uncontrolled despite this therapy. Over the past decades, research efforts into phenotyping of severe asthma and defining the pathological mechanisms of this disease were successful largely due to the development of appropriate animal models. Recent identification of distinct inflammatory patterns of severe asthma endotypes led to novel treatment approaches, including targeting specific cytokines or their receptors with neutralizing antibodies. Read More

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http://dx.doi.org/10.1016/j.imlet.2018.11.012DOI Listing
March 2019
2 Reads

IL-10 T follicular regulatory cells are associated with the pathogenesis of IgG4-related disease.

Immunol Lett 2019 Mar 15;207:56-63. Epub 2019 Jan 15.

Department of Human Immunology, Research Institute for Frontier Medicine, Sapporo Medical University School of Medicine, Chuo-ku, Sapporo 060-8556, Japan.

IgG4-related disease (IgG4-RD) is a chronic fibroinflammatory disease characterized by elevation of serum IgG4 level as well as infiltration of IgG4 plasma cells in various affected organs. The etiology of IgG4-RD is still not fully understood. Since IgG4-RD is more prevalent in the elderly, aging in itself is considered to be an important risk factor of IgG4-RD. Read More

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http://dx.doi.org/10.1016/j.imlet.2019.01.008DOI Listing
March 2019
14 Reads

Genetic variants of SMAD2/3/4/7 are associated with susceptibility to ulcerative colitis in a Japanese genetic background.

Immunol Lett 2019 Mar 14;207:64-72. Epub 2019 Jan 14.

Department of Pharmacotherapeutics, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1 Sakamoto, Nagasaki 852-8102, Japan.

Purpose: Inflammatory bowel disease (IBD), which includes Crohn's disease (CD) and ulcerative colitis (UC), is attributed to inappropriate inflammatory response in intestinal mucosa. Transforming growth factor β (TGF-β)/SMAD signaling plays key role in differentiation of naïve CD4 T cells to T helper 17 (Th17) cells or regulatory T (T) cells. This study aimed to investigate associations between single nucleotide polymorphisms (SNPs) of SMAD family genes and susceptibility to IBD in a Japanese cohort to elucidate genetic determinants of IBD. Read More

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http://dx.doi.org/10.1016/j.imlet.2019.01.007DOI Listing
March 2019
29 Reads

Co-expression of membrane-bound TNF-alpha type 1 and 2 receptors differ in the subsets of immunocompetent cells.

Immunol Lett 2019 Mar 11;207:1-5. Epub 2019 Jan 11.

Federal State Budgetary Scientific Institution "Research Institute of Fundamental and Clinical Immunology" (RIFCI), Novosibirsk, Russia.

The immunoregulatory cytokine tumor necrosis factor α plays crucial roles in the pathogenesis of a broad spectrum of disorders. However, its effect may depend on the expression and co-expression of receptors on the target cell. The aim of the present study was to evaluate the expression levels of type 1 and 2 tumor necrosis factor α receptors (TNFR1/2) on individual cell subsets from peripheral blood of healthy volunteers. Read More

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http://dx.doi.org/10.1016/j.imlet.2019.01.005DOI Listing
March 2019
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Corrigendum to "Ro60 inhibits colonic inflammation and fibrosis in a mouse model of dextran sulfate sodium-induced colitis" [Immunol. Lett. 176 (2016) 81-89].

Immunol Lett 2019 Jan 9. Epub 2019 Jan 9.

The Rheumatism Research Center, Catholic Research Institute of Medical Science, The Catholic University of Korea, College of Medicine, Seoul, Republic of Korea; Department of Biomedicine & Health Sciences, College of Medicine, The Catholic University of Korea, 222, Banpo-daero, Seocho-gu, Seoul, 06591, Republic of Korea. Electronic address:

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http://dx.doi.org/10.1016/j.imlet.2019.01.001DOI Listing
January 2019
2 Reads

Notch signaling induces lymphoproliferation, T helper cell activation and Th1/Th2 differentiation in leprosy.

Immunol Lett 2019 Mar 7;207:6-16. Epub 2019 Jan 7.

National JALMA Institute for Leprosy and Other Mycobacterial Diseases (ICMR), Agra, 282004, India. Electronic address:

The present study evaluates role of Notch1 signaling in the regulation of T cell immunity in leprosy. Peripheral blood mononuclear cells from leprosy patients and healthy controls were activated with Mycobacterium leprae antigens along with activation of Notch1 signaling pathway and then lymphoproliferation was analyzed by lymphocytes transformation test and the expression of Notch1 and its ligands DLL1, Jagged1 and Jagged 2, T cell activation marker and Th1-Th2 cytokines on Th cells in PBMCs of study subjects were analyzed by flow cytometry. Further, these parameters were also analyzed after inhibition of Notch1 signaling pathway. Read More

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http://dx.doi.org/10.1016/j.imlet.2019.01.003DOI Listing
March 2019
4 Reads

The multifaceted role of Notch signal in regulating T cell fate.

Immunol Lett 2019 Feb 7;206:59-64. Epub 2019 Jan 7.

Virology Section, Regional Medical Research Centre, NE Region, Indian Council of Medical Research, Dibrugarh, Assam, 786001, India. Electronic address:

Notch signaling pathway facilitates important cellular functions of the host. Notch signal is essential for the development of T cells, and the role of Notch in fine tuning of αβ versus γδ T cell lineage commitment is fundamentally different in mice and human. The Notch family of cell surface receptor likewise plays a critical role in regulating T cell activation, and influences T cell response both intrinsically and through the local environment. Read More

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http://dx.doi.org/10.1016/j.imlet.2019.01.004DOI Listing
February 2019
2 Reads

Haptoglobin improves acute phase response and endotoxin tolerance in response to bacterial LPS.

Immunol Lett 2019 Mar 6;207:17-27. Epub 2019 Jan 6.

Department of Microbiology, Osmania University, Hyderabad 500007, Telangana, India. Electronic address:

Sepsis is characterized by delayed acute phase response and lowered immune tolerance in patients. Acute phase serum proteins, like Haptoglobin (Hp), have been associated with increased mortality in bacteria mediated acute lung inflammation and sepsis in neonates. However, it's direct role in modulating the immune response by regulating pro-inflammatory mediators leading to immune tolerant state and if gender affects its expression levels during bacterial infection, especially in blood has not been fully explored. Read More

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http://dx.doi.org/10.1016/j.imlet.2019.01.002DOI Listing
March 2019
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Distinctly regulated functions and mobilization of CD11c-positive cells elicited by TLR3- and IPS-1 signaling in the cornea.

Immunol Lett 2019 Feb 17;206:49-53. Epub 2018 Dec 17.

Department of Frontier Medical Science and Technology for Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto, Japan.

The human ocular surface epithelium expresses TLR3, which recognizes double-stranded (ds) RNA mimicking polyinosine-polycytidylic acid (polyI:C). Its stimulation induces the secretion of the inflammatory cytokines such as interleukin (IL)-6, IL-8, and type I interferon. The cytoplasmic helicase proteins RIG-I and MDA5 are also expressed on the ocular surface. Read More

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http://dx.doi.org/10.1016/j.imlet.2018.12.004DOI Listing
February 2019
15 Reads

Identification and immune-related analysis of SNPs in Litopenaeus vannamei Toll3 receptor.

Immunol Lett 2019 Feb 11;206:19-27. Epub 2018 Dec 11.

Department of Biology and Guangdong Provincial Key Laboratory of Marine Biotechnology, Shantou University, Shantou, 515063, China. Electronic address:

Tolls and Toll-like receptors (TLRs), as innate immune-recognition receptors that recognize molecular patterns associated with microbial pathogens, play a critical role in antimicrobial immune responses. Here, we report on single nucleotide polymorphisms (SNPs) of Litopenaeus vannamei Toll3 (LvToll3). Multiple sequence alignment of the L. Read More

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http://dx.doi.org/10.1016/j.imlet.2018.12.002DOI Listing
February 2019
2.512 Impact Factor

A dual role of TGF-β in human osteoclast differentiation mediated by Smad1 versus Smad3 signaling.

Immunol Lett 2019 Feb 10;206:33-40. Epub 2018 Dec 10.

Rheumatology, College of Medicine, Korea University, Seoul, South Korea. Electronic address:

TGF-β1 is highly expressed in the synovial tissue of patients with rheumatoid arthritis and is known as a cytokine that plays an important role in tissue repair and immune cell regulation. However, the role of TGF-β1 is still unclear in osteoclastogenesis. In this study, we examined the effect of TGF-β1 on osteoclast differentiation and the underlying mechanism using healthy human peripheral blood monocytes. Read More

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http://dx.doi.org/10.1016/j.imlet.2018.12.003DOI Listing
February 2019
4 Reads

Soluble mannose receptor levels in blood correlate to disease severity in patients with community-acquired pneumonia.

Immunol Lett 2019 Feb 4;206:28-32. Epub 2018 Dec 4.

Department of R&D, Hycult Biotechnology, Uden, the Netherlands. Electronic address:

Purpose: Community-acquired pneumonia (CAP) is the most common form of pneumonia and is a leading infectious cause worldwide. Identification of patients that are at risk to develop severe disease has proven to be a major challenge. Soluble mannose receptor (sMR; sCD206) is a new serum marker for macrophage activation. Read More

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http://dx.doi.org/10.1016/j.imlet.2018.12.001DOI Listing
February 2019
16 Reads

Impact of activated invariant natural killer T cells on the expansion of regulatory T cell precursors in murine thymocytes in vitro.

Immunol Lett 2019 Feb 29;206:41-48. Epub 2018 Nov 29.

Department of Urology, Tokyo Women's Medical University, Kawadacho, Shinjuku-ku, Tokyo, 162-8666, Japan. Electronic address:

Tolerance induction is a goal of clinical transplantation to prevent graft rejection without the lifelong use of immunosuppressive drugs. In a series of mouse studies, we previously reported that the establishment of mixed chimerism by treatment with a ligand for invariant natural killer T (iNKT) cells with CD40 signal blockade makes it possible to prevent allograft rejection without immunosuppressants, and this approach fails in thymectomized recipient mice. In this study, we showed that iNKT cells in murine thymocyte cultures are indispensable for the expansion of CD4CD25Foxp3 regulatory T (Treg) cells as well as CD4CD25Foxp3 cells, which contained precursor Tregs (preTregs). Read More

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http://dx.doi.org/10.1016/j.imlet.2018.11.013DOI Listing
February 2019
13 Reads
2.512 Impact Factor

miR-181b regulates ER stress induced neuron death through targeting Heat Shock Protein A5 following intracerebral haemorrhage.

Immunol Lett 2019 Feb 29;206:1-10. Epub 2018 Nov 29.

Department of Neurology, Yongchuan Hospital, Chongqing Medical University, Chongqing, 402160, China. Electronic address:

Endoplasmic reticulum (ER) stress acts as a protein folding and contributes to neuronal damage and neurological deterioration following intracerebral hemorrhage (ICH). Heat Shock Protein A5 (HSPA5) serves as an essential regulator of the endoplasmic reticulum (ER) stress response. However, the specific mechanism has not been will identified. Read More

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http://dx.doi.org/10.1016/j.imlet.2018.11.014DOI Listing
February 2019
2 Reads
2.512 Impact Factor

Interaction and involvement of cellular adhesion molecules in the pathogenesis of Schistosomiasis mansoni.

Immunol Lett 2019 Feb 29;206:11-18. Epub 2018 Nov 29.

Departamento de Análises Clínicas e Toxicológicas, Faculdade de Farmácia, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil. Electronic address:

Parasites from genus Schistosoma currently infect more than 200 million people worldwide. Infection with Schistosoma mansoni causes intestinal schistosomiasis with geographical distribution across Africa, Middle East, Caribbean, Brazil, Venezuela and Suriname. People with Schistosomiasis mansoni suffer from a chronic disease as result of an exacerbated immune response to the eggs deposited in hepatic tissue. Read More

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http://dx.doi.org/10.1016/j.imlet.2018.11.011DOI Listing
February 2019
4 Reads

Passive immunotherapy with specific IgG fraction against autolysin: Analogous protectivity in the MRSA infection with antibiotic therapy.

Immunol Lett 2018 Nov 26. Epub 2018 Nov 26.

Recombinant Vaccine Research Center, Tehran University of Medical Sciences, Tehran, Iran.

Staphylococcus aureus is a leading infectious cause of life-threatening diseases in human beings, with no effective vaccine available to date against this bacterium. Treatment of methicillin-resistant S. aureus (MRSA) infections has become increasingly difficult because of the emergence of multidrug-resistant isolates. Read More

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http://dx.doi.org/10.1016/j.imlet.2018.11.010DOI Listing
November 2018
1 Read