32,292 results match your criteria Immunology Endocrine & Metabolic Agents in Medicinal Chemistry [Journal]


Summary of the 2018 Alcohol and Immunology Research Interest Group (AIRIG) meeting.

Alcohol 2018 Aug 24;77:11-18. Epub 2018 Aug 24.

Department of Surgery, Alcohol Research Program, Burn & Shock Trauma Research Institute, Loyola University Chicago Health Sciences Division, Maywood, IL, United States. Electronic address:

On January 26, 2018, the 23rd annual Alcohol and Immunology Research Interest Group (AIRIG) meeting was held at the University of Colorado Denver, Anschutz Medical Campus, Aurora, Colorado. The meeting consisted of plenary sessions with oral presentations and a poster presentation session. There were four plenary sessions that covered a wide range of topics relating to alcohol use: Alcohol and Liver Disease; Alcohol, Inflammation and Immune Response; Alcohol and Organ Injury; Heath Consequences and Alcohol Drinking. Read More

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http://dx.doi.org/10.1016/j.alcohol.2018.08.010DOI Listing

Depressive symptoms in inflammatory bowel disease: an extraintestinal manifestation of inflammation?

Clin Exp Immunol 2019 Feb 14. Epub 2019 Feb 14.

Centre for Inflammation Biology and Cancer Immunology, King's College London.

Depressive symptoms are reported by more than 20% of people with inflammatory bowel disease (IBD), whilst sleep difficulties and fatigue are even more common. Comorbid depressive symptoms predict a poor IBD course, including increased risk of relapse and surgery, which is inconsistently improved by psychological treatments. Rather than being distinct systems, there is compelling evidence for bidirectional communication between gut and brain, driven by neural, metabolic, endocrine and inflammatory mediators. Read More

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http://dx.doi.org/10.1111/cei.13276DOI Listing
February 2019

Role of leptin and ghrelin in the regulation of gonadal function.

Expert Rev Endocrinol Metab 2007 Mar;2(2):239-249

e University of Santiago de Compostela, Department of Medicine, Faculty of Medicine, Complejo Hospitalario Universitario de Santiago, 15705 Santiago de Compostela, Spain.

Gonadal development and function is sustained by the complex interaction of an array of regulatory signals that operate directly on the gonads and/or indirectly via modulation of gonadotropin secretion. During the last decade, different factors primarily involved in the control of food intake and energy balance have been demonstrated as putative modulators of different elements of the reproductive axis, including the gonads, thus helping to define the neuroendocrine basis for the link between body energy stores and fertility. These factors include not only the adipocyte-derived hormone leptin, which is indispensable for proper energy balance and reproduction, but also a number of neuropeptides and hormones of central and peripheral origin. Read More

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http://dx.doi.org/10.1586/17446651.2.2.239DOI Listing

Tyrosine kinase receptors are crucial for normal β-cell development and function.

Expert Rev Endocrinol Metab 2007 Mar;2(2):175-183

b The Scripps Research Institute, Department of Immunology, IMM23, 10550 North Torrey Pines Road, La Jolla, CA, 92037, USA.

Signaling pathways play critical roles in most physiological and pathological processes and convert an extracellular stimulus into a change of function in the recipient cell. Intracellular messages originate from the activation of membrane receptors by a variety of ligands, such as hormones, nutrients or growth factors. The receptors subsequently interact with specific intracellular cascades, triggering the phosphorylation of cell effectors. Read More

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http://dx.doi.org/10.1586/17446651.2.2.175DOI Listing

Role of IGF-I in Type 2 diabetes: a focus on the mouse model.

Expert Rev Endocrinol Metab 2008 Jan;3(1):43-49

b Department of Microbiology and Immunology, Faculty of Health Sciences, Ben Gurion University of the Negev, Soroka University Medical Center, PO Box 151, Beer Sheva 84101, Israel.

Insulin resistance, the key mechanism in Type 2 diabetes mellitus (T2DM) is also associated with the deregulation of other glucose homeostasis pathways, such as the growth hormone (GH)-IGF-I system. In this review, we summarize the endocrine and renal GH-IGF axis changes in db/db mice, a model of T2DM, and compare it with the nonobese diabetic mouse model of T1DM. In the latter, elevated circulating GH levels (associated with kidney disease) could be ameliorated with the use of GH antagonists. Read More

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http://dx.doi.org/10.1586/17446651.3.1.43DOI Listing
January 2008

Drug sensitivity testing on patient-derived sarcoma cells predicts patient response to treatment and identifies c-Sarc inhibitors as active drugs for translocation sarcomas.

Br J Cancer 2019 Feb 12. Epub 2019 Feb 12.

Department of Breast cancer, Endocrine tumors and Sarcoma, Karolinska University Hospital, Stockholm, Sweden.

Background: Heterogeneity and low incidence comprise the biggest challenge in sarcoma diagnosis and treatment. Chemotherapy, although efficient for some sarcoma subtypes, generally results in poor clinical responses and is mostly recommended for advanced disease. Specific genomic aberrations have been identified in some sarcoma subtypes but few of them can be targeted with approved drugs. Read More

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http://dx.doi.org/10.1038/s41416-018-0359-4DOI Listing
February 2019
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Immunomodulatory effects of synthetic endocrine disrupting chemicals on the development and functions of human immune cells.

Environ Int 2019 Feb 7;125:350-364. Epub 2019 Feb 7.

Department of Immunology, Medical University of Bialystok, Poland.

Endocrine disrupting chemicals (EDCs) are added to food, cosmetics, plastic packages, and children's toys and have thus become an integral part of the human environment. In the last decade, there has been increasing interest in the effect of EDCs on human health, including their impact on the immune system. So far, researchers have proved that EDCs (e. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01604120183196
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http://dx.doi.org/10.1016/j.envint.2019.01.078DOI Listing
February 2019
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Genetic Characteristics of Aldosterone-Producing Adenomas in Blacks.

Hypertension 2019 Feb 11:HYPERTENSIONAHA11812070. Epub 2019 Feb 11.

From the Department of Molecular and Integrative Physiology (K.N., W.E.R.), University of Michigan, Ann Arbor.

Somatic mutations have been identified in aldosterone-producing adenomas (APAs) in genes that include KCNJ5, ATP1A1, ATP2B3, and CACNA1D. Based on independent studies, there appears to be racial differences in the prevalence of somatic KCNJ5 mutations, particularly between East Asians and Europeans. Despite the high cardiovascular disease mortality of blacks, there have been no studies focusing on somatic mutations in APAs in this population. Read More

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http://dx.doi.org/10.1161/HYPERTENSIONAHA.118.12070DOI Listing
February 2019
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MYC promotes the development of papillary thyroid carcinoma by inhibiting the expression of lncRNA PAX8‑AS1:28.

Oncol Rep 2019 Feb 1. Epub 2019 Feb 1.

Department of Immunology, Wenzhou Medical University, Wenzhou, Zhejiang 325000, P.R. China.

As a common malignancy of the endocrine system, papillary thyroid carcinoma (PTC) seriously affects the quality of life of patients. lncRNA PAX8‑AS1:28, or lnc‑PSD4‑1:14 has been reported to be abnormally expressed in PTC. However, the function of PAX8‑AS1:28 in PTC is still unknown. Read More

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http://dx.doi.org/10.3892/or.2019.6996DOI Listing
February 2019
1 Read
2.191 Impact Factor

Concise Review: Canine Diabetes Mellitus as a Translational Model for Innovative Regenerative Medicine Approaches.

Stem Cells Transl Med 2019 Feb 5. Epub 2019 Feb 5.

Department of Pathology, Microbiology, and Immunology, School of Veterinary Medicine, University of California, Davis, Davis, California, USA.

Diabetes mellitus (DM) is a common spontaneous endocrine disorder in dogs, which is defined by persistent hyperglycemia and insulin deficiency. Like type 1 diabetes (T1D) in people, canine DM is a complex and multifactorial disease in which genomic and epigenomic factors interact with environmental cues to induce pancreatic β-cell loss and insulin deficiency, although the pathogenesis of canine DM is poorly defined and the role of autoimmunity is further controversial. Both diseases are incurable and require life-long exogenous insulin therapy to maintain glucose homeostasis. Read More

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http://dx.doi.org/10.1002/sctm.18-0163DOI Listing
February 2019
2 Reads

Clinical significance of filamin A in patients with acromegaly and its association with somatostatin and dopamine receptor profiles.

Sci Rep 2019 Feb 4;9(1):1122. Epub 2019 Feb 4.

Neuroendocrinology Research Center/Endocrinology Division, Medical School and Hospital Universitário Clementino Fraga Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.

Filamin-A (FLNA) plays a crucial role in somatostatin receptor (sst) subtype-2 signaling in somatotropinomas. Our objective was to investigate the in vivo association between FLNA and sst2 expression, sst5 expression, dopamine receptor subtype-2 (D2) expression, somatostatin receptor ligand (SRL) responsiveness and tumor invasiveness in somatotropinomas. Quantitative real-time PCR was used to evaluate the absolute mRNA copy numbers of FLNA/sst2/sst5/D2 in 96 somatotropinomas. Read More

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http://www.nature.com/articles/s41598-018-37692-3
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http://dx.doi.org/10.1038/s41598-018-37692-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6361919PMC
February 2019
2 Reads

Subclinical Lipopolysaccharide from Enteritidis Induces Dysregulation of Bioactive Substances from Selected Brain Sections and Glands of Neuroendocrine Axes.

Toxins (Basel) 2019 Feb 2;11(2). Epub 2019 Feb 2.

Department of Food Immunology and Microbiology, Institute of Animal Reproduction and Food Research, Polish Academy of Sciences in Olsztyn, 10-748 Olsztyn, Poland.

Bacterial lipopolysaccharide (LPS) can contribute to the pathogenesis and the clinical symptoms of many diseases such as cancer, mental disorders, neurodegenerative as well as metabolic diseases. The asymptomatic carrier state of spp. is a very important public health problem. Read More

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http://dx.doi.org/10.3390/toxins11020091DOI Listing
February 2019
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A Map of Human Type 1 Diabetes Progression by Imaging Mass Cytometry.

Cell Metab 2019 Jan 11. Epub 2019 Jan 11.

Institute of Molecular Life Sciences, University of Zurich, Zurich, Switzerland. Electronic address:

Type 1 diabetes (T1D) results from the autoimmune destruction of insulin-producing β cells. A comprehensive picture of the changes during T1D development is lacking due to limited sample availability, inability to sample longitudinally, and the paucity of technologies enabling comprehensive tissue profiling. Here, we analyzed 1,581 islets from 12 human donors, including eight with T1D, using imaging mass cytometry (IMC). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S15504131183069
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http://dx.doi.org/10.1016/j.cmet.2018.11.014DOI Listing
January 2019
1 Read

Changes of γδT cell subtypes during pregnancy and their influences in spontaneous abortion.

J Reprod Immunol 2019 Feb 25;131:57-62. Epub 2019 Jan 25.

Obstetrics and Gynecology Hospital, Fudan University, Shanghai, 200011, China; Department of Obstetrics and Gynecology of Shanghai Medical College, Fudan University, Shanghai, 200011, China; Shanghai Key Laboratory of Female Reproductive Endocrine Related Diseases, Shanghai, 200032, China; Key Laboratory of Reproduction Regulation of NPFPC, SIPPR, IRD, Shanghai 200032, China. Electronic address:

A successful pregnancy is a complicated process that involves the precisely timed regulation of endocrine as well as immune system. Despite increasing knowledge about immunology in gestation, the studies of immune cells in endometrium and decidua are still fragmented. Dynamic data is lacking on the transition of pre-pregnancy endometrial lymphocytes to initial pregnancy states as well as to second/third-trimester status. Read More

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http://dx.doi.org/10.1016/j.jri.2019.01.003DOI Listing
February 2019
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Association between CD16 monocytes in peripheral blood and clinical features and short-term therapeutic effects of polycystic ovary syndrome.

Int J Gynaecol Obstet 2019 Feb 2. Epub 2019 Feb 2.

Laboratory for Reproductive Immunology, Hospital and Institute of Obstetrics and Gynecology, Shanghai Medical School, Fudan University, Shanghai, China.

Objective: To evaluate the association between CD16 monocytes in peripheral blood and the clinical features and short-term therapeutic effects of polycystic ovary syndrome (PCOS).

Methods: This prospective cross-sectional study included women diagnosed with PCOS at a university hospital in Shanghai, China, between June 4 and November 28, 2016. Patients received Diane-35, metformin, or both combined for 3 months. Read More

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http://dx.doi.org/10.1002/ijgo.12779DOI Listing
February 2019
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Application of hairpin DNA-based biosensors with various signal amplification strategies in clinical diagnosis.

Biosens Bioelectron 2019 Mar 15;129:164-174. Epub 2019 Jan 15.

Aging Research Institute, Tabriz University of Medical Sciences, Tabriz, Iran; Department of Immunology, Faculty of Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran. Electronic address:

Biosensors have been commonly used in biomedical diagnostic tools in recent years, because of a wide range of application, such as point-of-care monitoring of treatment and disease progression, drug discovery, commonly use food control, environmental monitoring and biomedical research. Additionally, development of DNA biosensors has been increased enormously over the past few years as confirmed by the large number of scientific publications in this field. A wide range of techniques can be used for the development of DNA biosensors, such as DNA nano-machines and various signal amplification strategies. Read More

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http://dx.doi.org/10.1016/j.bios.2019.01.008DOI Listing

Effects of vitamin D supplements on frequency of CD4 T-cell subsets in women with Hashimoto's thyroiditis: a double-blind placebo-controlled study.

Eur J Clin Nutr 2019 Jan 29. Epub 2019 Jan 29.

Department of Immunology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.

Background: Vitamin D is a modulator of immune functions. Investigations on the mechanisms of vitamin D action and pathogenesis of Hashimoto's thyroiditis (HT) have revealed that vitamin D can reduce damages to thyroid cells caused by autoreactive immune cells.

Methods: Totally, 48 female patients with HT disease were introduced to the study by endocrinologists. Read More

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http://dx.doi.org/10.1038/s41430-019-0395-zDOI Listing
January 2019
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Survivin as a diagnostic and therapeutic marker for thyroid cancer.

Pathol Res Pract 2019 Jan 18. Epub 2019 Jan 18.

Department of Immunology, Faculty of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran. Electronic address:

Thyroid cancer (TC) is known as the most prevalent form of endocrine malignancy. With regard to high heterogeneity of the nodules, problem of discriminating between benign and malignant ones in terms of pathological characteristics, as well as lack of appropriate molecular markers; significant efforts are being made to identify molecular markers that able to detect tumorous lesions. Survivin, the newest member of the family of proteins inhibiting cell apoptosis, has been recently considered as a novel molecule marker for cancer. Read More

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http://dx.doi.org/10.1016/j.prp.2019.01.025DOI Listing
January 2019

Nanocurcumin improves regulatory T-cell frequency and function in patients with multiple sclerosis.

J Neuroimmunol 2019 Feb 17;327:15-21. Epub 2019 Jan 17.

Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran; Department of Immunology, School of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran. Electronic address:

Background: Multiple sclerosis is a chronic incapacitating disease of the central nervous system, it has been reported that the disturbance in the development and function of Treg subpopulations is associated with the disability status in the RRMS. Accordingly, in the current study, the objective was to specify nanocurcumin effects on Treg cells frequency, and function in patients with RRMS.

Methods And Materials: 50 patients with RRMS were enrolled in this study in which 25 were treated for at least six months with nanocurcumin capsules while the other half received placebo capsules as the control group. Read More

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http://dx.doi.org/10.1016/j.jneuroim.2019.01.007DOI Listing
February 2019
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2.467 Impact Factor

Editorial: Activation and de-activation of inflammatory pathways. The disequilibrium of immune-neuro-endocrine networks in psychiatric disorders.

Authors:
Hemmo A Drexhage

Brain Behav Immun 2019 Jan 22. Epub 2019 Jan 22.

Dept of Immunology, Erasmus Medical Center, Rotterdam, The Netherlands. Electronic address:

In this issue of BBI Melbourne et al describe a reduced activity of the JAK-STAT1 pathway in leukocytes of early and acute schizophrenia patients. This editorial discusses the report of Melbourne et al as being in accord with the view that active forms of schizophrenia are characterized by a de-activation of the Th1 driven M1/JAK-STAT1 mediated pro-inflammatory pathway in myeloid cells (macrophages, dendritic cells and microglia). Myeloid cells can be inflammatory activated and de-activated via various different molecular pathways (leading to various types of macrophages, such as e. Read More

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http://dx.doi.org/10.1016/j.bbi.2019.01.007DOI Listing
January 2019

Intervals between bone mineral density testing with dual-energy X-ray absorptiometry scans in clinical practice.

Osteoporos Int 2019 Jan 24. Epub 2019 Jan 24.

Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Boston, MA, USA.

Intervals between dual-energy X-ray absorptiometry (DXA) scans were evaluated in a large cohort of typical clinical practice. Intensive DXA scanning (intervals < 23 months) decreased substantially, from 16.7% in 2006 to 6. Read More

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http://dx.doi.org/10.1007/s00198-019-04847-5DOI Listing
January 2019
1 Read

Steroid-Free Immune Suppression Impairs Glycemic Control in a Healthy Cynomolgus Monkey.

Cell Transplant 2019 Jan 24:963689718823505. Epub 2019 Jan 24.

1 Diabetes Research Institute, Miller School of Medicine, University of Miami, FL, USA.

The need for chronic immune suppression (IS) is one of the hurdles precluding widespread use of islet cell transplantation to restore glycemic control in patients with type 1 diabetes. We report the case of a healthy nonhuman primate (NHP) treated on and off for over 2.5 years with steroid-free IS, consisting of daclizumab induction and maintenance therapy with rapamycin and low dose tacrolimus. Read More

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http://dx.doi.org/10.1177/0963689718823505DOI Listing
January 2019

Integrating multiple of the median values of serological markers with the risk cut-off value in Down syndrome screening.

Biosci Trends 2018 ;12(6):613-619

Obstetrics and Gynecology Hospital of Fudan University.

To assess the predictive value of integrating multiple of the median (MOM) with the risk cut-off value for serological screening of Down syndrome. In this retrospective study, women with singleton pregnancies who underwent triple serological screening for Down syndrome were followed, and their screening results and pregnancy outcomes were recorded. The range of MoM value of each indicator was calculated, different protocols integrating various MoM values with the risk cut-off value were compared. Read More

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https://www.jstage.jst.go.jp/article/bst/12/6/12_2018.01232/
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http://dx.doi.org/10.5582/bst.2018.01232DOI Listing
January 2018
3 Reads

Advanced Age Impairs Intestinal Antimicrobial Peptide Response and Worsens Fecal Microbiome Dysbiosis Following Burn Injury in Mice.

Shock 2019 Jan 18. Epub 2019 Jan 18.

Department of Surgery, Division of GI, Trauma and Endocrine Surgery, and Burn Research Program, University of Colorado Denver, Anschutz Medical Campus, Aurora, CO 80045.

Maintenance of the commensal bacteria that comprise the gut microbiome is essential to both gut and systemic health. Traumatic injury, such as burn, elicits a number of changes in the gut, including a shift in the composition of the microbiome (dysbiosis), increased gut leakiness, and bacterial translocation into the lymphatic system and bloodstream. These effects are believed to contribute to devastating secondary complications following burn, including pneumonia, acute respiratory distress syndrome, multi-organ failure, and septic shock. Read More

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http://dx.doi.org/10.1097/SHK.0000000000001321DOI Listing
January 2019
11 Reads

Correction: Trophoblast-derived CXCL16 induces M2 macrophage polarization that in turn inactivates NK cells at the maternal-fetal interface.

Cell Mol Immunol 2019 Jan 22. Epub 2019 Jan 22.

Laboratory for Reproductive Immunology, Key Laboratory of Reproduction Regulation of NPFPC, SIPPR, Shanghai Key Laboratory of Female Reproductive Endocrine Related Diseases, Hospital and Institute of Obstetrics and Gynecology, IRD, Fudan University, Shanghai Medical College, Shanghai, China.

In this article, published online 27 March 2018, in the "ACKNOWLEDGEMENTS", it should be supplemented as follows: "This study was funded by a grant from the National Natural Science Foundation of China, number 81490744, awarded to Da-Jin Li." The authors regret the omission. Read More

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http://dx.doi.org/10.1038/s41423-018-0194-9DOI Listing
January 2019

Adjuvant rituximab, a potential treatment for the young patient with Graves' hyperthyroidism (RiGD): study protocol for a single-arm, single-stage, phase II trial.

BMJ Open 2019 Jan 21;9(1):e024705. Epub 2019 Jan 21.

Department of Paediatric Endocrinology, Institute of Genetic Medicine, Newcastle University, Great North Children's Hospital, Newcastle upon Tyne, UK.

Introduction: Graves' disease (Graves' hyperthyroidism) is a challenging condition for the young person and their family. The excess thyroid hormone generated by autoimmune stimulation of the thyroid stimulating hormone receptor on the thyroid gland can have a profound impact on well-being. Managing the young person with Graves' hyperthyroidism is more difficult than in older people because the side effects of conventional treatment are more significant in this age group and because the disease tends not to resolve spontaneously in the short to medium term. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-024705DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6347892PMC
January 2019
2 Reads

Quantitative Proteomics by SWATH-MS of Maternal Plasma Exosomes Determine Pathways Associated with Term and Preterm Birth.

Endocrinology 2019 Jan 21. Epub 2019 Jan 21.

Department of Obstetrics and Gynecology, Ochsner Baptist Hospital, New Orleans, Louisiana, USA.

Introduction: Exosomes are membrane-bound nanovesicles that transport molecular signals between cells. This study determined changes in maternal plasma exosome proteomics contents in term and preterm births.

Methods: Maternal plasma (MP) samples were collected from group 1: term not-in labor (TNIL, n=13); group 2: term in labor (TL, n= 11), group 3: preterm premature rupture of membranes (pPROM, n=8); and group 4: preterm birth (PTB, n=13). Read More

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http://dx.doi.org/10.1210/en.2018-00820DOI Listing
January 2019
2 Reads

Case of reversible diabetes mellitus in the setting of benign Pheochromocytoma.

J Clin Transl Endocrinol Case Rep 2018 Dec 2;10:1-3. Epub 2018 Aug 2.

Department of Medicine, Division of Diabetes, Endocrinology, and Metabolism, Vanderbilt University Medical Center, Nashville, TN, USA.

Pheochromocytomas have been shown to impair glucose tolerance and, rarely, to precipitate overt diabetes mellitus. We report here a case of a large pheochromocytoma in a woman with a recent diagnosis of diabetes mellitus that proved difficult to control despite high-dose insulin therapy who had complete resolution of her hyperglycemia following adrenalectomy. Her dramatic presentation demonstrates the need to consider this etiology in patients with new-onset insulin resistance and hypertension. Read More

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http://dx.doi.org/10.1016/j.jecr.2018.07.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6338797PMC
December 2018

Genome-wide association study of body fat distribution identifies adiposity loci and sex-specific genetic effects.

Nat Commun 2019 01 21;10(1):339. Epub 2019 Jan 21.

Department of Immunology, Genetics and Pathology, Science for Life Laboratory, Uppsala University, Box 256, 751 05, Uppsala, Sweden.

Body mass and body fat composition are of clinical interest due to their links to cardiovascular- and metabolic diseases. Fat stored in the trunk has been suggested to be more pathogenic compared to fat stored in other compartments. In this study, we perform genome-wide association studies (GWAS) for the proportion of body fat distributed to the arms, legs and trunk estimated from segmental bio-electrical impedance analysis (sBIA) for 362,499 individuals from the UK Biobank. Read More

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http://dx.doi.org/10.1038/s41467-018-08000-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341104PMC
January 2019
1 Read

Metabolic syndrome and endocrine status in HIV-infected transwomen.

AIDS 2019 Jan 16. Epub 2019 Jan 16.

Infectious and Tropical Diseases Department, Hôpitaux Universitaires Paris Nord Val de Seine (HUPNVS), AP-HP, Paris, France.

Background: HIV-infected transwomen face multiple specific issues. Economic and social marginalization, sex work, substance abuse, hormonal consumption and silicone injection may affect the course of HIV infection and lead to metabolic and endocrine complications.

Methods: A matched case-control study was performed between 2013 and 2015 in a University Hospital and compared metabolic syndrome, thyroid and adrenal functions in HIV-infected transwomen (i. Read More

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http://dx.doi.org/10.1097/QAD.0000000000002152DOI Listing
January 2019
2 Reads

HS promotes proliferation of endometrial stromal cells via activating the NF-κB pathway in endometriosis.

Am J Transl Res 2018 15;10(12):4247-4257. Epub 2018 Dec 15.

Department of Cervical Disease, Shanghai First Maternity and Infant Hospital, Tongji University School of Medicine Shanghai, People's Republic of China.

Hydrogen sulfide (HS) is substantially converted from cysteine by the enzymes cystathionine β-synthase (CBS) and cystathionine γ-lyase (CSE). HS can profoundly affect most organ systems in animals and humans by inducing a wide range of physiological functions. However, the roles of HS in the progression of endometriosis remain unknown. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6325523PMC
December 2018
2 Reads

Rare case of Hashimoto's encephalitis mimicking grief reaction.

BMJ Case Rep 2019 Jan 14;12(1). Epub 2019 Jan 14.

Department of Diabetes and Endocrinology, Royal Glamorgan Hospital, Llantrisant, UK.

A 46-year-old woman was admitted with tonic-clonic seizures. She was noticed to be withdrawn and low in mood for few months. She had reduced level of consciousness with hyper-reflexia and myoclonus. Read More

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http://dx.doi.org/10.1136/bcr-2018-227190DOI Listing
January 2019
6 Reads

Clinical, Histochemical, and Molecular Study of Three Turkish Siblings Diagnosed with H Syndrome, and Literature Review.

Horm Res Paediatr 2019 Jan 9:1-10. Epub 2019 Jan 9.

Department of Paediatric Allergy and Immunology, Eskisehir Osmangazi University School of Medicine, Eskisehir, Turkey.

Background: The term "H syndrome" was coined to denote the major clinical findings, which include hyperpigmentation, hypertrichosis, hearing loss, hepatosplenomegaly, hyperglycaemia, hypogonadism, hallux flexion contractures, and short height.

Objective: To report the clinical, endocrinological, histochemical, and genetic findings of three siblings.

Methods: Skin and liver biopsies were taken to investigate the histochemical characteristics of hyperpigmented hypertrichotic skin lesions and massive hepatomegaly. Read More

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https://www.karger.com/Article/FullText/495190
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http://dx.doi.org/10.1159/000495190DOI Listing
January 2019
5 Reads

Blockade of CTLA-4 and Tim-3 pathways induces fetal loss with altered cytokine profiles by decidual CD4T cells.

Cell Death Dis 2019 Jan 8;10(1):15. Epub 2019 Jan 8.

Laboratory for Reproductive Immunology, NHC Key Lab of Reproduction Regulation(Shanghai Institute of Planned Parenthood Research), Shanghai Key Laboratory of Female Reproductive Endocrine Related Diseases, Hospital of Obstetrics and Gynecology, Fudan University Shanghai Medical College, Shanghai, P.R. China.

The single and/or combination use of immune checkpoint blockade therapies in human infectious diseases and cancer are rapidly expanding. Despite early efforts, substantial uncertainty remains about the safety and efficacy of immune checkpoint blockade in some populations. Cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) and T-cell immunoglobulin mucin-3 (Tim-3) are the major targetable co-inhibitory receptors on T cells. Read More

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http://www.nature.com/articles/s41419-018-1251-0
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http://dx.doi.org/10.1038/s41419-018-1251-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6325160PMC
January 2019
11 Reads

Neurog3-Independent Methylation Is the Earliest Detectable Mark Distinguishing Pancreatic Progenitor Identity.

Dev Cell 2019 Jan;48(1):49-63.e7

Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA; Program in Developmental Biology and Center for Stem Cell Biology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA. Electronic address:

In the developing pancreas, transient Neurog3-expressing progenitors give rise to four major islet cell types: α, β, δ, and γ; when and how the Neurog3 cells choose cell fate is unknown. Using single-cell RNA-seq, trajectory analysis, and combinatorial lineage tracing, we showed here that the Neurog3 cells co-expressing Myt1 (i.e. Read More

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http://dx.doi.org/10.1016/j.devcel.2018.11.048DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6327977PMC
January 2019
2 Reads

Regulation of GDNF expression in Sertoli cells.

Reproduction 2019 Jan 1. Epub 2019 Jan 1.

M Hofmann , Endocrine Neoplasia and Hormonal Disorders, University of Texas MD Anderson Cancer Center, Houston, United States.

Sertoli cells regulate male germ cell proliferation and differentiation and are a critical component of the spermatogonial stem cell (SSC) niche, where homeostasis is maintained by the interplay of several signaling pathways and growth factors. These factors are secreted by Sertoli cells located within the seminiferous epithelium, and by interstitial cells residing between the seminiferous tubules. Sertoli cells and peritubular myoid cells produce glial cell line-derived neurotrophic factor (GDNF), which binds to the RET/GFRA1 receptor complex at the surface of undifferentiated spermatogonia. Read More

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http://dx.doi.org/10.1530/REP-18-0239DOI Listing
January 2019
1 Read

The Role of Extracellular Vesicles and PIBF in Embryo-Maternal Immune-Interactions.

Front Immunol 2018 13;9:2890. Epub 2018 Dec 13.

Department of Physiology and Immunology, Faculty of Medicine, University of Rijeka, Rijeka, Croatia.

Pregnancy represents a unique immunological situation. Though paternal antigens expressed by the conceptus are recognized by the immune system of the mother, the immune response does not harm the fetus. Progesterone and a progesterone induced protein; PIBF are important players in re-adjusting the functioning of the maternal immune system during pregnancy. Read More

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http://dx.doi.org/10.3389/fimmu.2018.02890DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6300489PMC
December 2018

Gene expression profiling identifies potential molecular markers of papillary thyroid carcinoma.

Cancer Biomark 2018 Dec 22. Epub 2018 Dec 22.

Department of Microbiology and Immunology, New York Medical College, Valhalla, NY, USA.

Background: Thyroid cancer is the most common endocrine malignancy worldwide, with the predominant form papillary thyroid carcinoma (PTC) representing approximately 80% of cases.

Objective: This study was addressed to identify potential genes and pathways involved in the pathogenesis of PTC and potential novel biomarkers for this disease.

Methods: Gene expression profiling was carried out by DNA microarray technology. Read More

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https://www.medra.org/servlet/aliasResolver?alias=iospress&a
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http://dx.doi.org/10.3233/CBM-181758DOI Listing
December 2018
6 Reads

Insights of Efferocytosis in Normal and Pathological Pregnancy.

Am J Reprod Immunol 2019 Jan 4:e13088. Epub 2019 Jan 4.

Laboratory for Reproductive Immunology, Hospital of Obstetrics and Gynecology, Fudan University, Shanghai, 200011, People's Republic of China.

Efferocytosis, which is known as the phagocytic clearance of dying cells by professional as well as non-professional phagocytes, including a great number of intracellular/extracellular factors and signals, is interrelated with the immune system, contributing to local and systemic homeostasis, especially in tissues with high constitutive rates of apoptosis. Accumulating studies have indicated that immune dysregulation is associated with the pathogenesis of the female reproductive system, which causes Pre-eclampsia(PE), Recurrent Spontaneous Abortion (RSA), ruptured ectopic pregnancy, and so on. And some studies have revealed the pleiotropic and essential role of efferocytosis in these obstetrical disorders. Read More

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http://dx.doi.org/10.1111/aji.13088DOI Listing
January 2019
2 Reads

Metabolic syndrome mediates proinflammatory responses of inflammatory cells in preeclampsia.

Am J Reprod Immunol 2019 Jan 5:e13086. Epub 2019 Jan 5.

Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.

Problem: To investigate whether metabolic syndrome (MetS) is associated with exacerbation of inflammatory responses in preeclamptic (PE) patients, the dynamic changes of Th17 and Treg cells, monocytes, cytokines, and transcription pattern of inflammasome-related genes were analyzed in 35 women with PE suffering from MetS in comparison to 38 PE women without MetS and healthy pregnant women.

Method Of Study: Expression of inflammasome-related genes, cytokines, and also TLR4 was measured using real-time PCR. Serum and medium supernatant cytokines levels of PBMCs and serum levels of HMGB1 and Caspase-1 were also evaluated by ELISA. Read More

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http://dx.doi.org/10.1111/aji.13086DOI Listing
January 2019
2 Reads

Trophoblast-derived hyaluronan promotes the regulatory phenotype of decidual macrophages.

Reproduction 2019 Feb;157(2):189-198

The Affiliated Suzhou Hospital of Nanjing Medical University/Suzhou Municipal Hospital, Suzhou, China.

There is delicate crosstalk between fetus-derived trophoblasts (Tros) and maternal cells during normal pregnancy. Dysfunctions in interaction are highly linked to some pregnancy complications, such as recurrent spontaneous abortion (RSA), pre-eclampsia and fetal growth restriction. Hyaluronan (HA), the most abundant component of extracellular matrix, has been reported to act as both a pro- and an anti-inflammatory molecule. Read More

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https://rep.bioscientifica.com/view/journals/rep/157/2/REP-1
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http://dx.doi.org/10.1530/REP-18-0450DOI Listing
February 2019
10 Reads

Polycystic Ovarian Condition May Be a Risk Factor for Ovarian Tumor Development in the Laying Hen Model of Spontaneous Ovarian Cancer.

J Immunol Res 2018 25;2018:2590910. Epub 2018 Nov 25.

Department of Pathology, Rush University Medical Center, Chicago, IL, USA.

Chronic inflammation and long-standing oxidative stress are potential predisposing factors for developing malignancies, including ovarian cancer (OVCA). Information on the association of ovarian chronic abnormal conditions, including polycystic ovarian syndrome (PCOS), with the development of OVCA is unknown. The goal of this study was to examine if polycystic ovarian conditions are associated with OVCA development. Read More

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http://dx.doi.org/10.1155/2018/2590910DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6286744PMC
January 2019
9 Reads

Pre-exposure with influenza A virus A/WSN/1933(H1N1) resulted in viral shedding reduction from pigs challenged with either swine H1N1 or H3N2 virus.

Vet Microbiol 2019 Jan 16;228:26-31. Epub 2018 Nov 16.

Department of Biology and Microbiology, South Dakota State University, Brookings, SD, 57007, USA; BioSNTR, Brookings, SD, 57007, USA. Electronic address:

There is an urgent need to develop a broad-spectrum vaccine that can effectively prevent or eliminate the spread of co-circulating swine influenza virus strains in multiple lineages or subtypes. We describe here that pre-exposure with a live virus generated via a A/WSN/1933(H1N1) reverse genetics system resulted in a significant reduction of viral shedding from pigs exposed to either a swine H1N1 virus or a swine H3N2 virus. At 3-day post challenge (DPC), approximately 1 log and 1. Read More

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http://dx.doi.org/10.1016/j.vetmic.2018.11.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6314213PMC
January 2019
1 Read
2.511 Impact Factor

Temporal relationships between systemic lupus erythematosus and comorbidities.

Rheumatology (Oxford) 2018 Dec 19. Epub 2018 Dec 19.

Division of Rheumatology, Orthopaedics, and Dermatology, School of Medicine, University of Nottingham, Nottingham, UK.

Objective: To examine the burden of comorbidities prior to and after the diagnosis of SLE and its impact on mortality.

Methods: We identified 1605 incident cases of SLE and 6284 matched controls from the UK primary care. The risks of comorbidities before (prevalence; odds ratios) and after SLE diagnosis (incidence; hazard ratios) and the impact of comorbidities at diagnosis on all-cause mortality were estimated. Read More

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http://dx.doi.org/10.1093/rheumatology/key335DOI Listing
December 2018
3 Reads
4.475 Impact Factor

Cognitive costs of reproduction: life-history trade-offs explain cognitive decline during pregnancy in women.

Biol Rev Camb Philos Soc 2018 Dec 26. Epub 2018 Dec 26.

Department of Environmental Health, Faculty of Health Sciences, Jagiellonian University Medical College, Krakow 31-531, Poland.

Life-history theory predicts that access to limited resources leads to trade-offs between competing body functions. Women, who face higher costs of reproduction when compared to men, should be especially vulnerable to these trade-offs. We propose the 'cognitive costs of reproduction hypothesis', which states that energy trade-offs imposed by reproduction may lead to a decline in maternal cognitive function during gestation. Read More

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http://dx.doi.org/10.1111/brv.12494DOI Listing
December 2018
1 Read

The development of a GPR44 targeting radioligand [C]AZ12204657 for in vivo assessment of beta cell mass.

EJNMMI Res 2018 Dec 27;8(1):113. Epub 2018 Dec 27.

Science for Life Laboratory, Department of Medicinal Chemistry, Uppsala University, Uppsala, Sweden.

Background: The G-protein-coupled receptor 44 (GPR44) is a beta cell-restricted target that may serve as a marker for beta cell mass (BCM) given the development of a suitable PET ligand.

Methods: The binding characteristics of the selected candidate, AZ12204657, at human GPR44 were determined using in vitro ligand binding assays. AZ12204657 was radiolabeled using C- or H-labeled methyl iodide ([C/H]CHI) in one step, and the conversion of [C/H]CHI to the radiolabeled product [C/H]AZ12204657 was quantitative. Read More

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https://ejnmmires.springeropen.com/articles/10.1186/s13550-0
Publisher Site
http://dx.doi.org/10.1186/s13550-018-0465-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6306373PMC
December 2018
4 Reads

Gestational Diabetes and T-cell (Th1/Th2/Th17/Treg) Immune Profile.

In Vivo 2019 Jan-Feb;33(1):31-40

2nd Department of Obstetrics and Gynecology, Medical School, Aretaieion University Hospital, National and Kapodistrian University of Athens, Athens, Greece.

Background/aim: Gestational diabetes mellitus (GDM) is a common pregnancy complication, characterized by insulin resistance and low-grade systemic inflammation with a pro-inflammatory immune system response. Our objective was to study the peripheral Th1, Th2, Th17 and Treg response in GDM compared to normal pregnancy.

Materials And Methods: Th1, Th2, Th17 and Treg subsets was determined by flow cytometry based on staining for specific intracellular cytokines, as well as C-reactive protein (CRP) and total IgE circulating levels. Read More

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http://iv.iiarjournals.org/lookup/doi/10.21873/invivo.11435
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http://dx.doi.org/10.21873/invivo.11435DOI Listing
October 2018
6 Reads

Senescent Phenotype Induced by p90RSK-NRF2 Signaling Sensitizes Monocytes and Macrophages to Oxidative Stress in HIV Individuals: Implications for Atherogenesis.

Circulation 2018 Oct 26. Epub 2018 Oct 26.

Department of Cardiology, University of Texas MD Anderson Cancer Center, UNITED STATES.

Background: The incidence of cardiovascular disease (CVD) is higher in HIV patients than it is in the average population, and combination antiretroviral therapy (cART) is a recognized risk factor for CVD. However, the molecular mechanisms that link cART and CVD are currently unknown. Our study explores the role of the activation of p90RSK, a reactive oxygen species (ROS)-sensitive kinase, in engendering senescent phenotype in macrophages and accelerating atherogenesis in patients undergoing cART. Read More

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http://dx.doi.org/10.1161/CIRCULATIONAHA.118.036232DOI Listing
October 2018
15 Reads

Correction of Hyperglycemia in Diabetic Rats With the Use of Microencapsulated Young Market Pig Islets.

Transplant Proc 2018 Dec 11;50(10):3895-3899. Epub 2018 Sep 11.

Department of Surgery, Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, People's Republic of China. Electronic address:

Objective: The aim of this work was to investigate the transplantation efficacy of microencapsulated young market pig islets in a diabetic rat model.

Methods: Islets were isolated and purified from young market pigs obtained from a local slaughterhouse. The islets were encapsulated in barium alginate and subjected to a glucose-induced insulin release functional assay in culture. Read More

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http://dx.doi.org/10.1016/j.transproceed.2018.09.017DOI Listing
December 2018

Insulin autoimmune syndrome: Three case reports.

Medicine (Baltimore) 2018 Dec;97(51):e13486

Department of Endocrinology, the People's Hospital of China Three Gorges University & The First People's Hospital of Yichang, Yichang, Hubei Province, China.

Rationale: Insulin autoimmune syndrome (IAS) is a rare endocrine disease characterized by repeated fasting hypoglycemia or episodes of hypoglycemia late after meals, elevated serum insulin, and positivity for insulin autoantibody (IAA) or insulin receptor antibody (IRA). We summarize the clinical manifestations and treatment experiences of 3 patients with IAS.

Patient Concerns: One patient with >20-year history of type 2 diabetes mellitus had irregular episodes of hypoglycemia 2 years of after treatment with insulin. Read More

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http://Insights.ovid.com/crossref?an=00005792-201812210-0002
Publisher Site
http://dx.doi.org/10.1097/MD.0000000000013486DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6320147PMC
December 2018
11 Reads
5.723 Impact Factor