32,480 results match your criteria Immunology Endocrine & Metabolic Agents in Medicinal Chemistry [Journal]


Regulation of estrogen signaling and breast cancer proliferation by an ubiquitin ligase TRIM56.

Oncogenesis 2019 Apr 18;8(5):30. Epub 2019 Apr 18.

Henan Key Laboratory of Immunology and Targeted Therapy, School of Laboratory Medicine, Henan Collaborative Innovation Center of Molecular Diagnosis and Laboratory Medicine, Xinxiang Medical University, 453003, Xinxiang, Henan, P.R. China.

Breast cancer ranks no. 1 in women cancer worldwide, while 60-70% are estrogen receptor alpha positive. The estrogen selective modulators, such as tamoxifen, become the effective drugs for controlling ER alpha breast cancer progression. Read More

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http://www.nature.com/articles/s41389-019-0139-x
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http://dx.doi.org/10.1038/s41389-019-0139-xDOI Listing
April 2019
1 Read

Undifferentiated spermatogonia regulate expression through NOTCH signaling and drive germ cell differentiation.

FASEB J 2019 Apr 16:fj201802361R. Epub 2019 Apr 16.

Department of Endocrine Neoplasia and Hormonal Disorders, University of Texas MD Anderson Cancer Center, Houston, Texas, USA.

Cytochrome P450 family 26 subfamily B member 1 (CYP26B1) regulates the concentration of all-trans retinoic acid (RA) and plays a key role in germ cell differentiation by controlling local distribution of RA. The mechanisms regulating expression in postnatal Sertoli cells, the main components of the stem cell niche, are so far unknown. During gonad development, expression of is maintained by Steroidogenic Factor 1 (SF-1) and Sex-Determining Region Y Box-9 (SOX9), which ensure that RA is degraded and germ cell differentiation is blocked. Read More

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http://dx.doi.org/10.1096/fj.201802361RDOI Listing
April 2019
1 Read

High prevalence of benign mammary tumors in a rat model of polycystic ovary syndrome during postmenopausal period.

Gynecol Endocrinol 2019 Apr 16:1-6. Epub 2019 Apr 16.

a Reproductive Endocrinology Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences , Tehran , Iran.

Polycystic ovary syndrome (PCOS) is one of the most common endocrine disorders in reproductive-age women. Significant associations between PCOS and benign breast diseases (BBD) and a possibly potential association between PCOS and breast cancer have been reported. The etiology of these events of mammary glands in PCOS remains unclear. Read More

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http://dx.doi.org/10.1080/09513590.2019.1576613DOI Listing
April 2019
1 Read

The absolute counts of peripheral T lymphocyte subsets in patient with ankylosing spondylitis and the effect of low-dose interleukin-2.

Medicine (Baltimore) 2019 Apr;98(15):e15094

Department of Rheumatology and Immunology, The Second Hospital of Shanxi Medical University, Taiyuan.

The aim of this analysis is to investigate the level of T cell subsets in ankylosing spondylitis (AS) and the effect of low-dose interleukin 2 (IL-2).This is a retrospective cohort study, we collected basic information, inflammatory markers, BASDAI scores, and T lymphocyte subsets of peripheral blood in patients with AS, baseline analysis, correlation analysis and comparative analysis before and after treatment were performed.Data from 73 patients (of these, 36 patients were treated with IL-2) and 85 the health were included. Read More

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http://dx.doi.org/10.1097/MD.0000000000015094DOI Listing
April 2019
1 Read

MIR205HG Is a Long Noncoding RNA that Regulates Growth Hormone and Prolactin Production in the Anterior Pituitary.

Dev Cell 2019 Apr 3. Epub 2019 Apr 3.

Department of Immunology University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA; Department of Microbiology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA; Department of Pediatrics, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA. Electronic address:

MicroRNAs (miRNAs) are processed from primary miRNA transcripts (pri-miRNAs), many of which are annotated as long noncoding RNAs (lncRNAs). We assessed whether MIR205HG, the host gene for miR-205, has independent functions as an lncRNA. Comparing mice with targeted deletions of MIR205HG and miR-205 revealed a functional role for the lncRNA in the anterior pituitary. Read More

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http://dx.doi.org/10.1016/j.devcel.2019.03.012DOI Listing

SET domain containing 1B gene (SETD1B) is mutated in primary hepatic neuroendocrine tumors.

Int J Cancer 2019 Apr 11. Epub 2019 Apr 11.

Beijing 302 Hospital/5th Medical Center of Chinese PLA General of Hospital, Beijing 100039, China.

Primary hepatic neuroendocrine tumors (PHNETs) are extremely rare NETs originating from the liver. These tumors are associated with heterogeneous prognosis, and few treatment targets for PHNETs have been identified. Because the major genetic alterations in PHNET are still largely unknown, we performed whole-exome sequencing of 22 paired tissues from PHNET patients and identified 22 recurring mutations of somatic genes involved in the following activities: epigenetic modification (BPTF, MECP2 and WDR5), cell cycle (TP53, ATM, MED12, DIDO1 and ATAD5) and neural development (UBR4, MEN1, GLUL and GIGYF2). Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/ijc.32334
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http://dx.doi.org/10.1002/ijc.32334DOI Listing
April 2019
3 Reads

Use of extracellular vesicles from lymphatic drainage as surrogate markers of melanoma progression and mutation.

J Exp Med 2019 Apr 11. Epub 2019 Apr 11.

Microenvironment and Metastasis Laboratory, Molecular Oncology Program, Spanish National Cancer Research Center, Madrid, Spain

Liquid biopsies from cancer patients have the potential to improve diagnosis and prognosis. The assessment of surrogate markers of tumor progression in circulating extracellular vesicles could be a powerful non-invasive approach in this setting. We have characterized extracellular vesicles purified from the lymphatic drainage also known as exudative seroma (ES) of stage III melanoma patients obtained after lymphadenectomy. Read More

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http://dx.doi.org/10.1084/jem.20181522DOI Listing
April 2019
12.515 Impact Factor

Sperm DNA fragmentation valued by SCSA and its correlation with conventional sperm parameters in male partner of recurrent spontaneous abortion couple.

Biosci Trends 2019 Apr 11. Epub 2019 Apr 11.

Laboratory for Reproductive Immunology, Hospital & Institute of Obstetrics and Gynecology, Shanghai Medical College, Fudan University.

The objective of this study is to evaluate the predictive value of sperm DNA fragmentation Index (DFI) in unexplained recurrent spontaneous abortion (RSA) and to investigate its correlation with conventional sperm parameters. Besides, we aimed to reveal the necessity of establishing a DFI clinical threshold of each laboratory for the prognostic diagnosis of RSA and establish our own DFI threshold. Semen samples were collected from male partners of RSA patients (n = 139) and healthy recent fathers (control, n = 200). Read More

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http://dx.doi.org/10.5582/bst.2018.01292DOI Listing
April 2019
2 Reads

Variants in the BACH2 and CLEC16A gene may be associated with susceptibility to insulin-triggered type 1 diabetes.

J Diabetes Investig 2019 Apr 10. Epub 2019 Apr 10.

Department of Diabetes and Molecular Genetics, Ehime University Graduate School of Medicine, To-on, Ehime, Japan.

Aim/introduction: Insulin administration was found to trigger type 1 diabetes (T1D) in six cases of Japanese type 2 diabetes patients (T2D) with T1D high-risk HLA class II (IDDM1) and the class I allele of the insulin gene VNTR genotype (IDDM2). The objective of this study was to assess the contribution of non-HLA single nucleotide polymorphisms (SNPs) to the risk of developing insulin-triggered T1D.

Materials And Methods: We genotyped thirteen T1D susceptible SNPs in the six cases and compared them with those in Japanese controls (Hap Map3-JPT). Read More

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http://dx.doi.org/10.1111/jdi.13057DOI Listing
April 2019
5 Reads

Papillary thyroid carcinoma behavior: clues in the tumor microenvironment.

Endocr Relat Cancer 2019 Apr 1. Epub 2019 Apr 1.

V Weiss, Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, 37232-2102, United States.

The prevalence of thyroid carcinoma is increasing and represents the most common endocrine malignancy, with papillary thyroid carcinoma (PTC) being the most frequent subtype. The genetic alterations identified in PTCs fail to distinguish tumors with different clinical behaviors, such as extra-thyroidal extension and lymph node metastasis. We hypothesize that the immune microenvironment may play a critical role in tumor invasion and metastasis. Read More

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http://dx.doi.org/10.1530/ERC-19-0074DOI Listing
April 2019
1 Read

Targeted deletion of Tcf7l2 in adipocytes promotes adipocyte hypertrophy and impaired glucose metabolism.

Mol Metab 2019 Mar 14. Epub 2019 Mar 14.

Department of Biochemistry, University of Utah School of Medicine, Salt Lake City, UT, USA. Electronic address:

Objective: Activation of the Wnt-signaling pathway is known to inhibit differentiation in adipocytes. However, there is a gap in our understanding of the transcriptional network regulated by components of the Wnt-signaling pathway during adipogenesis and in adipocytes during postnatal life. The key intracellular effectors of the Wnt-signaling pathway occur through TCF transcription factors such as TCF7L2 (transcription factor-7-like 2). Read More

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http://dx.doi.org/10.1016/j.molmet.2019.03.003DOI Listing
March 2019
3 Reads

Gut T Cells Feast on GLP-1 to Modulate Cardiometabolic Disease.

Cell Metab 2019 Apr;29(4):787-789

Division of Cellular & Molecular Biology, Diabetes Research Group, Toronto General Hospital Research Institute (TGHRI), University Health Network, Toronto, ON M5G 1L7, Canada; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON M5S 1A8, Canada; Department of Immunology, University of Toronto, Toronto, ON M5S 1A8, Canada; Department of Pathology, University Health Network, Toronto, ON M5G 2C4, Canada; Buck Institute for Research on Aging, 8001 Redwood Boulevard, Novato, CA 94945, USA. Electronic address:

Glucagon-like peptide-1 (GLP-1) is an enteroendocrine hormone that controls insulin secretion, intestinal function, and food intake. Recently in Nature, He et al. (2019) reported that gut intraepithelial T cells regulate GLP-1 bioavailability by capturing it on GLP-1 receptors and impacting L-cell numbers. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S15504131193013
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http://dx.doi.org/10.1016/j.cmet.2019.03.002DOI Listing
April 2019
6 Reads

Thyroid Cancer in Ecuador, a 16 years population-based analysis (2001-2016).

BMC Cancer 2019 Apr 2;19(1):294. Epub 2019 Apr 2.

OneHealth Research Group, Faculty of Medicine, Universidad de las Americas, Calle de los Colimes y Avenida De los Granados, 170137, Quito, Ecuador.

Background: Thyroid cancer is the most frequent endocrine neoplasia worldwide. Information from Andean countries is scarce. In Ecuador there is no reports available of the epidemiology of this type of cancer. Read More

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http://dx.doi.org/10.1186/s12885-019-5485-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6444541PMC
April 2019
2 Reads

Developmental exposure to chemicals associated with unconventional oil and gas extraction alters immune homeostasis and viral immunity of the amphibian Xenopus.

Sci Total Environ 2019 Mar 26;671:644-654. Epub 2019 Mar 26.

Department of Microbiology and Immunology, University of Rochester, United States of America.

Although aquatic vertebrates and humans are increasingly exposed to water pollutants associated with unconventional oil and gas extraction (UOG), the long-term effects of these pollutants on immunity remains unclear. We have established the amphibian Xenopus laevis and the ranavirus Frog Virus 3 (FV3) as a reliable and sensitive model for evaluating the effects of waterborne pollutants. X. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00489697193139
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http://dx.doi.org/10.1016/j.scitotenv.2019.03.395DOI Listing
March 2019
3 Reads

Therapeutic approaches for targeting ROR-1 in cancer cells.

Expert Opin Ther Targets 2019 Apr 1. Epub 2019 Apr 1.

d Stem Cell Research Center , Tabriz University of Medical Sciences , Tabriz , Iran.

Introduction: There is a high expression of ROR1, a tyrosine kinase receptor, in various tumor-cell types. ROR1 is involved in many key processes in cancer including proliferation, survival and metastasis. Hence, ROR1 is an attractive and promising therapeutic target. Read More

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http://dx.doi.org/10.1080/14728222.2019.1602608DOI Listing
April 2019
1 Read

Chinese herbal medicine for acute upper respiratory tract infections and reproductive safety: A systematic review.

Biosci Trends 2019 Mar 31. Epub 2019 Mar 31.

Laboratory for Reproductive Immunology, Hospital & Institute of Obstetrics and Gynecology, Shanghai Medical College, Fudan University.

Acute upper respiratory tract infections (AURTIs) are common and self-limited in people with normal immunity but sometimes lead to poor clinical outcomes under specific conditions such as pregnancy if not treated appropriately. Chinese herbal medicines (CHM), which are widely used to treat AURTIs, have proven to be effective in preclinical and clinical studies. This review focuses on the bioactivities of typical CHM and the adverse reactions they cause, and especially issues with reproductive safety when treating AURTIs. Read More

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http://dx.doi.org/10.5582/bst.2018.01298DOI Listing
March 2019
2 Reads

Leveraging Prior Knowledge of Endocrine Immune Regulation in the Therapeutically Relevant Phenotyping of Women With Chronic Fatigue Syndrome.

Clin Ther 2019 Mar 28. Epub 2019 Mar 28.

Institute for Neuro Immune Medicine, Nova Southeastern University, Fort Lauderdale, FL, USA; Miami Veterans Affairs Medical Center, Miami, FL, USA.

Purpose: The complex and varied presentation of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) has made it difficult to diagnose, study, and treat. Its symptoms and likely etiology involve multiple components of endocrine and immune regulation, including the hypothalamic-pituitary-adrenal axis, the hypothalamic-pituitary-gonadal axis, and their interactive oversight of immune function. We propose that the persistence of ME/CFS may involve changes in the regulatory interactions across these physiological axes. Read More

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http://dx.doi.org/10.1016/j.clinthera.2019.03.002DOI Listing
March 2019
3 Reads

FGF19 subfamily members: FGF19 and FGF21.

J Physiol Biochem 2019 Mar 29. Epub 2019 Mar 29.

Department of Laboratory Diagnostics, Independent Public Clinical Hospital No. 2, Pomeranian Medical University, Szczecin, Poland.

Fibroblast growth factors (FGF) constitute a large family of proteins with pleiotropic effects on development, organogenesis, and metabolism. The FGF19 subclass includes growth factors circulating with the blood referred to as endocrine FGF. Representatives of the FGF19 subclass, including FGF19, FGF21, and FGF23, act via FGFR receptors. Read More

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http://dx.doi.org/10.1007/s13105-019-00675-7DOI Listing
March 2019
1 Read

Cyclosporine A improves pregnancy outcomes in women with recurrent pregnancy loss and elevated Th1/Th2 ratio.

J Cell Physiol 2019 Mar 28. Epub 2019 Mar 28.

Stem Cell Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.

Recurrent pregnancy loss (RPL) is a one of the most common obstetrical complications. Since, the successful pregnancy occurs in T helper 2 (Th2)-dominant situation and since, Th1 type immunity is related to pregnancy failure, we investigated the effects of cyclosporine on Th1 and Th2 cells in RPL women. Totally, 76 RPL patients (38 women as treated group and 38 as control group) were included in this study. Read More

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http://dx.doi.org/10.1002/jcp.28543DOI Listing
March 2019
1 Read
3.839 Impact Factor

Dog appeasing pheromone prevents the androgen surge and may reduce contact dominance and active submission after stressful interventions in African wild dogs (Lycaon pictus).

PLoS One 2019 27;14(3):e0212551. Epub 2019 Mar 27.

Gamete and Embryology (GAME) Laboratory, College of Public Health, Medical and Veterinary Sciences, James Cook University, Townsville, QLD, Australia.

The endangered African wild dog (AWD; Lycaon pictus) is a highly social canid living in packs with a separate male and female hierarchy. Immobilisation, handling and translocations are acute stressors for AWDs, however such interventions are often needed for species management. In addition, new pack formation or temporary pack separation can lead to an increase in intra-pack aggression. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0212551PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6436694PMC
March 2019
3 Reads

A novel mutation in INS gene linked to permanent neonatal diabetes mellitus.

Endocrine 2019 Mar 26. Epub 2019 Mar 26.

Department of Endocrinology, The Second Affiliated Hospital of Soochow University, 215004, Suzhou, China.

Purpose: Neonatal diabetes mellitus (NDM) is caused by mutations in the genes responsible for pancreatic β cell mass or function. This study aimed to screen the mutations in the KCNJ11, ABCC8, and INS genes in a Chinese patient with clinical features of NDM.

Methods: The entire coding sequence and exon/intron boundaries of KCNJ11, ABCC8, and INS genes were detected by Sanger sequencing. Read More

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http://dx.doi.org/10.1007/s12020-019-01905-0DOI Listing
March 2019
1 Read

Physiological Regulation of Innate Lymphoid Cells.

Front Immunol 2019 12;10:405. Epub 2019 Mar 12.

Molecular Immunology Division, Walter and Eliza Hall Institute of Medical Research, Melbourne, VIC, Australia.

Discovery of innate lymphoid cells (ILCs) have provoked a paradigm shift in our understanding of the immune protection. Their constitutive presence and activity at the body's barrier surfaces ensure the maintenance of the tissue homeostasis and immune protection. This complex family has distinct and non-redundant functions that can have both beneficial and detrimental effects on disease outcome. Read More

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http://dx.doi.org/10.3389/fimmu.2019.00405DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6422966PMC

Novel therapeutic approaches in utilizing platelet lysate in regenerative medicine: Are we ready for clinical use?

J Cell Physiol 2019 Mar 25. Epub 2019 Mar 25.

Stem Cell Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.

Hemoderivative materials are used to treat different diseases. These derivatives include platelet-rich plasma, serum, platelet gel, and platelet lysate (PL). Among them, PL contains more growth factors than the others and its production is inexpensive and easy. Read More

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http://dx.doi.org/10.1002/jcp.28496DOI Listing
March 2019
2 Reads

Detection of neoantigen-specific T cells following a personalized vaccine in a patient with glioblastoma.

Oncoimmunology 2019 25;8(4):e1561106. Epub 2019 Jan 25.

Andrew M. and Jane M. Bursky Center for Human Immunology and Immunotherapy Programs, Washington University School of Medicine, St. Louis, MO, USA.

Neoantigens represent promising targets for personalized cancer vaccine strategies. However, the feasibility of this approach in lower mutational burden tumors like glioblastoma (GBM) remains unknown. We have previously reported the use of an immunogenomics pipeline to identify candidate neoantigens in preclinical models of GBM. Read More

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https://www.tandfonline.com/doi/full/10.1080/2162402X.2018.1
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http://dx.doi.org/10.1080/2162402X.2018.1561106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6422384PMC
January 2019
3 Reads

Decidual stromal cells promote the differentiation of CD56 CD16 NK cells by secreting IL-24 in early pregnancy.

Am J Reprod Immunol 2019 Mar 23:e13110. Epub 2019 Mar 23.

Laboratory of Reproductive Immunology, Hospital of Obstetrics and Gynecology, Fudan University, Shanghai, China.

Problem: Decidual stromal cells (DSCs) are important origins of cytokines to modulate maternal-fetal immunotolerance and provide a feasible environment for embryo implantation and development. Interleukin (IL)-24 is a multifunctional cancer killing cytokine and a pleiotropic immunoregulator with complex potency according to tissue or cell types. Its role in establishment and maintenance of normal pregnancy is largely unknown. Read More

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http://dx.doi.org/10.1111/aji.13110DOI Listing
March 2019
1 Read

Modeling gut-brain interactions in zebrafish.

Brain Res Bull 2019 Mar 16;148:55-62. Epub 2019 Mar 16.

School of Pharmacy, Southwest University, Chongqing, China; Scientific Research Institute of Physiology and Basic Medicine, Novosibirsk, Russia; Ural Federal University, Ekaterinburg, Russia; Institute of Translational Biomedicine, St. Petersburg State University, St. Petersburg, Russia; Institute of Experimental Medicine, Almazov National Medical Research Centre, Ministry of Healthcare of Russian Federation, St. Petersburg, Russia; Granov Russian National Research Center of Radiology and Surgical Technologies, Ministry of Healthcare of Russian Federation, St. Petersburg, Russia. Electronic address:

Mounting clinical and experimental evidence suggests the gut-brain interplay as a novel important paradigm in translational neuroscience, including the critical role for gut microbiota in modulating brain development and behavior, as well as neuroimmune and neuroendocrine responses. Animal models are an indispensable tool in studying the central nervous system (CNS) disorders and their mechanisms. Recently, the zebrafish (Danio rerio) has become a powerful new model organism in neuroscience, including studying the gut-brain axis. Read More

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http://dx.doi.org/10.1016/j.brainresbull.2019.03.003DOI Listing
March 2019
2 Reads

Hyperprolactinemia is associated with a high prevalence of serum autoantibodies, high levels of inflammatory cytokines and an abnormal distribution of peripheral B-cell subsets.

Endocrine 2019 Mar 18. Epub 2019 Mar 18.

Department of Rheumatology and Immunology, Shanghai Changzheng Hospital, Second Military Medical University, Shanghai, China.

Purpose: Hyperprolactinemia (HPRL) has been reported in many autoimmune diseases. However, the serum autoantibody profile and peripheral B-cell subset distribution in women with HPRL are largely unknown. The current study aimed to investigate the autoantibody prevalence and cytokine levels as well as to further explore the B-cell subset distribution in women with HPRL. Read More

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http://dx.doi.org/10.1007/s12020-019-01896-yDOI Listing
March 2019
1 Read
3.527 Impact Factor

A long-term growth hormone treatment stimulates growth and lipolysis in gilthead sea bream juveniles.

Comp Biochem Physiol A Mol Integr Physiol 2019 Jun 15;232:67-78. Epub 2019 Mar 15.

Department of Cell Biology, Physiology and Immunology, Faculty of Biology, University of Barcelona, 08028 Barcelona, Spain. Electronic address:

The enhancement of the endocrine growth hormone (GH)/insulin-like growth factor I (IGF-I) system by the treatment with a sustained release formulation of a recombinant bovine GH (rBGH), is a good strategy to investigate growth optimization in aquaculture fish species. To further deepen into the knowledge of rBGH effects in fish and to estimate the growth potential of juveniles of gilthead sea bream, the present work evaluated rBGH injection on growth, GH/IGF-I axis and lipid metabolism modulation, and explored the conservation of GH effects provoked by the in vivo treatment using in vitro models of different tissues. The rBGH treatment increased body weight and specific growth rate (SGR) in juveniles and potentiated hyperplastic muscle growth while reducing circulating triglyceride levels. Read More

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http://dx.doi.org/10.1016/j.cbpa.2019.03.012DOI Listing
June 2019
2 Reads
2.371 Impact Factor

Baseline levels determine magnitude of increment in 25 hydroxy vitamin D following vitamin D3 prescription in healthy subjects.

Endocrine 2019 Mar 14. Epub 2019 Mar 14.

Department of Internal Medicine, Ali-EbneAbitaleb Hospital, Zahedan University of Medical Sciences, Zahedan, Iran.

Introduction: Vitamin D deficiency is a major health problem which affects about one billion people in the world. Although, vitamin D supplementation is recommended as standard treatment of vitamin D deficiency, there are controversies on dose response relationship. In this regard, the present study aimed to determine the impact of vitamin D3 supplement on raising of serum 25 hydroxyvitamin D[25(OH)D] in healthy subjects with varying degrees of vitamin D deficiency. Read More

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http://dx.doi.org/10.1007/s12020-019-01881-5DOI Listing
March 2019
1 Read

Acute effect of an amino acid mixture in the rat glycemic profile.

J Cell Biochem 2019 Mar 14. Epub 2019 Mar 14.

Faculdade de Ciências da Nutrição e Alimentação, Universidade do Porto, Porto, Portugal.

Amino acid mixtures (AAM) are protein substitutes used for phenylketonuria treatment, but their metabolic effects have not been well characterized. The objective of this study was to compare the acute glycemic response to free amino acids (free AA) from AAM with the response to intact protein (iProtein). Male Wistar rats (n = 14) were administered by gavage a bolus of free AA (n = 7) or iProtein as albumin (n = 7) containing equivalent amounts of nitrogen. Read More

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http://dx.doi.org/10.1002/jcb.28576DOI Listing
March 2019
1 Read

Pharmaceutical Interventions in Chronic Fatigue Syndrome: A Literature-based Commentary.

Clin Ther 2019 Mar 11. Epub 2019 Mar 11.

Institute for Neuro Immune Medicine, Nova Southeastern University, Fort Lauderdale, FL, USA; Department of Clinical Immunology, Nova Southeastern University, Fort Lauderdale, FL, USA.

Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a debilitating disorder characterized by prolonged periods of fatigue, chronic pain, depression, and a complex constellation of other symptoms. Currently, ME/CFS has no known cause, nor are the mechanisms of illness well understood. Therefore, with few exceptions, attempts to treat ME/CFS have been directed mainly toward symptom management. Read More

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http://dx.doi.org/10.1016/j.clinthera.2019.02.011DOI Listing
March 2019
1 Read

Combined inhibition of STAT3 and DNA repair in palbociclib-resistant ER-positive breast cancer.

Clin Cancer Res 2019 Mar 13. Epub 2019 Mar 13.

Experimental Radiation Oncology, University of Texas MD Anderson Cancer Center

Purpose: CDK4/6 inhibitors are currently used in combination with endocrine therapy to treat advanced hormone receptor-positive, HER2-negative breast cancer. While this treatment doubles time to progression compared to endocrine therapy alone, about 25-35% of patients do not respond, and almost all patients eventually acquire resistance. Discerning the mechanisms of resistance to CDK4/6 inhibition is crucial in devising alternative treatment strategies. Read More

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http://dx.doi.org/10.1158/1078-0432.CCR-18-3274DOI Listing
March 2019
5 Reads
8.722 Impact Factor

Prognostic impact of TP53INP1 gene expression in estrogen receptor α-positive breast cancer patients.

Jpn J Clin Oncol 2019 Mar 11. Epub 2019 Mar 11.

Department of Breast Surgery, Nagoya City University Graduate School of Medical Sciences.

Background: Tumor protein 53-induced nuclear protein 1 (TP53INP1) is a key stress protein with tumor suppressor function. Several studies have demonstrated TP53INP1 downregulation in many cancers. In this study, we investigated the correlations of TP53INP1 mRNA expression in breast cancer tissues with prognosis and the correlations of microRNAs that regulate TP53INP1 expression in breast cancer patients with long follow-up. Read More

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http://dx.doi.org/10.1093/jjco/hyz029DOI Listing
March 2019
2 Reads

The Wolbachia mobilome in Culex pipiens includes a putative plasmid.

Nat Commun 2019 03 5;10(1):1051. Epub 2019 Mar 5.

Graduate Program in the Biophysical Sciences, University of Chicago, Chicago, IL, 60637, USA.

Wolbachia is a genus of obligate intracellular bacteria found in nematodes and arthropods worldwide, including insect vectors that transmit dengue, West Nile, and Zika viruses. Wolbachia's unique ability to alter host reproductive behavior through its temperate bacteriophage WO has enabled the development of new vector control strategies. However, our understanding of Wolbachia's mobilome beyond its bacteriophages is incomplete. Read More

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http://dx.doi.org/10.1038/s41467-019-08973-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6401122PMC
March 2019
2 Reads

The anti-hyperglycemia effects of Rhizoma Coptidis alkaloids: A systematic review of modern pharmacological studies of the traditional herbal medicine.

Fitoterapia 2019 Mar 2;134:210-220. Epub 2019 Mar 2.

School of Life Sciences, Southwest University, Chongqing 400715, China. Electronic address:

Hyperglycemia is a common endocrine system disease, which seriously affects people's health with a increasing morbidity in recent years. Rhizoma Coptidis (RC), one of the most commonly used traditional Chinese medicines, has been applied to treat diabetes in clinic for thousands of years. Since scientists demonstrated that alkaloids from RC owned the amazing anti-hyperglycemia activities 30 years ago, these compounds have been widely used for the treatment of diabetes and hyperglycemia with unconspicuous toxicities and side effects. Read More

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http://dx.doi.org/10.1016/j.fitote.2019.03.003DOI Listing
March 2019
5 Reads

GNAI1 and GNAI3 Reduce Colitis-Associated Tumorigenesis in Mice by Blocking IL6 Signaling and Downregulating Expression of GNAI2.

Gastroenterology 2019 Mar 2. Epub 2019 Mar 2.

Cancer Biology Program, University of Hawaii Cancer Center, 701 Ilalo Street, Honolulu, HI 96813; The Second Affiliated Hospital, The State Key Laboratory of Respiratory Disease, Guangdong Provincial Key Laboratory of Allergy & Clinical Immunology, Guangzhou Medical University, Guangzhou 510260, Guangdong, China. Electronic address:

Background & Aims: Interleukin 6 (IL6) and tumor necrosis factor (TNF) contribute to the development of colitis-associated cancer (CAC). We investigated these signaling pathways and the involvement of G protein subunit alpha i1 (GNAI1), GNAI2, and GNAI3 in the development of CAC in mice and humans.

Methods: B6;129 wild-type (control) or mice with disruption of Gnai1, Gnai2, and/or Gnai3 or conditional disruption of Gnai2 in CD11c+ or epithelial cells were given dextran sulfate sodium (DSS) to induce colitis followed by azoxymethane (AOM) to induce carcinogenesis; some mice were given an antibody against IL6. Read More

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http://dx.doi.org/10.1053/j.gastro.2019.02.040DOI Listing
March 2019
6 Reads

HCV-Induced Epigenetic Changes Associated With Liver Cancer Risk Persist After Sustained Virologic Response.

Gastroenterology 2019 Mar 2. Epub 2019 Mar 2.

INSERM U1110, Institut de Recherche sur les Maladies Virales et Hépatiques, Strasbourg, France; Université de Strasbourg, Strasbourg, France; Institut Hospitalo-Universitaire, Pôle Hépato-digestif, Nouvel Hôpital Civil, Strasbourg, France; Institut Universitaire de France (IUF), Paris, France. Electronic address:

Background & Aims: Chronic hepatitis C virus (HCV) infection is an important risk factor for hepatocellular carcinoma (HCC). Despite effective antiviral therapies, the risk for HCC is decreased but not eliminated after a sustained virologic response (SVR) to direct-acting antiviral (DAA) agents, and the risk is higher in patients with advanced fibrosis. We investigated HCV-induced epigenetic alterations that might affect risk for HCC after DAA treatment in patients and mice with humanized livers. Read More

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http://dx.doi.org/10.1053/j.gastro.2019.02.038DOI Listing

A transcriptomic regulatory network among miRNAs, piRNAs, circRNAs, lncRNAs and mRNAs regulates microcystin-leucine arginine (MC-LR)-induced male reproductive toxicity.

Sci Total Environ 2019 Jun 28;667:563-577. Epub 2019 Feb 28.

Immunology and Reproduction Biology Laboratory & State Key Laboratory of Analytical Chemistry for Life Science, Medical School, Nanjing University, Nanjing, Jiangsu 210093, China; Jiangsu Key Laboratory of Molecular Medicine, Nanjing University, Nanjing, Jiangsu 210093, China. Electronic address:

Microcystin-leucine arginine (MC-LR) which is produced by cyanobacteria is a potent toxin for the reproductive system. Our previous work has demonstrated that both acute and chronic reproductive toxicity engendered by MC-LR can result in the decline of sperm quality and damage of testicular structures in male mice. The present study was designed to investigate the impact of chronic low-dose exposure to MC-LR on the regulation of RNA networks including mRNA, microRNA (miRNA), piwi-associated RNA (piRNA), covalently closed circular RNA (circRNA) and long non-coding RNA (lncRNA) in testicular tissues. Read More

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http://dx.doi.org/10.1016/j.scitotenv.2019.02.393DOI Listing
June 2019
3 Reads
4.099 Impact Factor

Effects of divergent selection upon adrenocortical activity on immune traits in pig.

BMC Vet Res 2019 Mar 4;15(1):71. Epub 2019 Mar 4.

IECM, INRA, Oniris, La Chantrerie, CS 40706, F-44307, Nantes Cedex 3, France.

Background: The sustainability of farming and animal welfare requires the reconsideration of current selection schemes. In particular, implementation of new selection criteria related to animal health and welfare should help to produce more robust animals and to reduce anti-microbial use. The hypothalamo-pituitary-adrenocortical (HPA) axis plays a major role in metabolic regulation and adaptation processes and its activity is strongly influenced by genetic factors. Read More

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http://dx.doi.org/10.1186/s12917-019-1809-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6398250PMC
March 2019
6 Reads

Anti-inflammatory cytokines in endometriosis.

Cell Mol Life Sci 2019 Mar 2. Epub 2019 Mar 2.

Laboratory for Reproductive Immunology, NHC Key Lab of Reproduction Regulation (Shanghai Institute of Planned Parenthood Research), Hospital of Obstetrics and Gynecology, Fudan University, Shanghai, 200090, People's Republic of China.

Although the pathogenesis of endometriosis is not fully understood, it is often considered to be an inflammatory disease. An increasing number of studies suggest that differential expression of anti-inflammatory cytokines (e.g. Read More

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http://dx.doi.org/10.1007/s00018-019-03056-xDOI Listing
March 2019
2 Reads

Intestinal transcriptional profiling reveals fava bean-induced immune response in DBA/1 mice.

Biol Res 2019 Mar 1;52(1). Epub 2019 Mar 1.

Department of Biochemistry and Molecular Biology, Hainan Medical College, Haikou, 571199, China.

Background: Fava beans (FBs) have long been used as food, and their principal disadvantage is derived from their haemotoxicity. We hypothesized that FB ingestion alters the intestinal gene expression pattern, thereby inducing an immune response.

Results: In-depth sequence analysis identified 769 differentially expressed genes (DEGs) associated with the intestine in FB-treated DBA/1 mouse intestines. Read More

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https://biolres.biomedcentral.com/articles/10.1186/s40659-01
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http://dx.doi.org/10.1186/s40659-019-0216-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6396536PMC
March 2019
7 Reads

Estrogen-mediated protection against coronary heart disease: The role of the Notch pathway.

J Steroid Biochem Mol Biol 2019 Feb 26;189:87-100. Epub 2019 Feb 26.

Maria Cecilia Hospital, GVM Care & Research, Cotignola, RA, Italy; Department of Morphology, Surgery and Experimental Medicine, University of Ferrara, Ferrara, Italy; Laboratory for Technologies of Advanced Therapies (LTTA), University of Ferrara, Ferrara, Italy. Electronic address:

Estrogen regulates a plethora of biological processes, under physiological and pathological conditions, by affecting key pathways involved in the regulation of cell proliferation, fate, survival and metabolism. The Notch receptors are mediators of communication between adjacent cells and are key determinants of cell fate during development and in postnatal life. Crosstalk between estrogen and the Notch pathway intervenes in many processes underlying the development and maintenance of the cardiovascular system. Read More

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http://dx.doi.org/10.1016/j.jsbmb.2019.02.008DOI Listing
February 2019
8 Reads

Dendritic Cells Exposed to Triiodothyronine Deliver Pro-Inflammatory Signals and Amplify IL-17-Driven Immune Responses.

Cell Physiol Biochem 2019 28;52(2):354-367. Epub 2019 Feb 28.

Centro de Investigaciones en Bioquímica Clínica e Inmunología (CIBICI-CONICET) and Departamento de Bioquímica Clínica, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, Córdoba, Argentina,

Background/aims: Although a cross-talk between immune and endocrine systems has been well established, the precise pathways by which these signals co-regulate pro- and antiinflammatory responses on antigen-presenting cells remain poorly understood. In this work we investigated the mechanisms by which triiodothyronine (T3) controls T cell activity via dendritic cell (DC) modulation.

Methods: DCs from wild-type (WT) and IL-6-deficient mice were pulsed with T3. Read More

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http://dx.doi.org/10.33594/000000025DOI Listing
March 2019
2 Reads

Bidirectional regulation between 1st trimester HTR8/SVneo trophoblast cells and in vitro differentiated Th17/Treg cells suggest a fetal-maternal regulatory loop in human pregnancy.

Am J Reprod Immunol 2019 May 11;81(5):e13106. Epub 2019 Apr 11.

Laboratory for Reproductive Immunology, NHC Key Lab of Reproduction Regulation (Shanghai Institute of Planned Parenthood Research), Shanghai Key Laboratory of Female Reproductive Endocrine Related Diseases, Hospital of Obstetrics and Gynecology, Fudan University Shanghai Medical College, Shanghai, China.

Problem: During normal pregnancy, delicate crosstalk is established between fetus-derived trophoblasts and maternal immune cells to ensure maternal-fetal tolerance and successful placentation. Dysfunction in these interactions has been highly linked to certain pregnancy complications.

Method Of Study: Naïve CD4 T cells were cultivated with or without 1st trimester derived trophoblast cell line HTR8/SVneo cells in the absence or presence of T helper 17 (Th17) or regulatory (Treg)cell-inducing differentiation conditions. Read More

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http://dx.doi.org/10.1111/aji.13106DOI Listing

Diversity and association of HLA/KIR receptors with type 2 diabetes in South India.

Int J Immunogenet 2019 Feb 27. Epub 2019 Feb 27.

Department of Immunology, School of Biological Sciences, Madurai Kamaraj University, Madurai, Tamil Nadu, India.

The present study was undertaken to delineate the association(s) of KIR-HLA combination in South Indian Type 2 diabetes mellitus (T2DM) patients. The T2DM patients (n = 343) and healthy controls (n = 309) were genotyped for KIR/HLA ligands by PCR-SSP method. The increased frequency of activatory KIR (aKIR) 2DS2 (OR = 1. Read More

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http://dx.doi.org/10.1111/iji.12417DOI Listing
February 2019
1.338 Impact Factor

Nanocurcumin: A novel strategy in treating ankylosing spondylitis by modulating Th17 cells frequency and function.

J Cell Biochem 2019 Feb 25. Epub 2019 Feb 25.

Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.

Ankylosing spondylitis (AS) is a chronic rheumatic disease which mainly affects the axial skeleton and sacroiliac joints. T-helper 17 (Th17) cells have been reportedly involved in AS pathogenesis. Nanocurcumin is considered to be beneficial, as an anti-inflammatory compound, in AS patients treatment. Read More

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http://dx.doi.org/10.1002/jcb.28488DOI Listing
February 2019
3 Reads
3.263 Impact Factor

The involvement of the progesterone receptor in PIBF and Gal-1 expression in the mouse endometrium.

Am J Reprod Immunol 2019 May 22;81(5):e13104. Epub 2019 Mar 22.

Department of Medical Biology and Central Electron Microscope Laboratory, Medical School, Pecs University, Pecs, Hungary.

Problem: The progesterone-regulated genes, PIBF and Gal-1, are key players in the feto-maternal immunological interaction. This study aims to investigate the expression of PIBF and Gal-1 in WT and progesterone receptor KO models as well as subsequent effects of PIBF on decidualization of stromal cells.

Method Of The Study: PRAKO, PRBKO and PRKO BALB/c mice were used for assessing the role of PR isoforms in PIBF induction. Read More

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http://dx.doi.org/10.1111/aji.13104DOI Listing

Endothelial dysfunction in pregnancy metabolic disorders.

Biochim Biophys Acta Mol Basis Dis 2019 Feb 19. Epub 2019 Feb 19.

Departamento de Ciencias Biologicas, Facultad de Ciencias de la Vida, Universidad Andres Bello, 8370146 Santiago, Chile; Millennium Institute on Immunology and Immunotherapy, 8331150 Santiago, Chile. Electronic address:

In recent years, the vascular endothelium has gained attention as a key player in the initiation and development of pregnancy disorders. Endothelium acts as an endocrine organ that preserves the homeostatic balance by responding to changes in metabolic status. However, in metabolic disorders, endothelial cells adopt a dysfunctional function, losing their normal responsiveness. Read More

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http://dx.doi.org/10.1016/j.bbadis.2019.02.009DOI Listing
February 2019
1 Read

A 61 year old man with pancreatitis, pituitary dysfunction, and painful exophthalmos.

BMJ 2019 Feb 21;364:l93. Epub 2019 Feb 21.

Imperial Centre for Endocrinology, Imperial College Healthcare NHS Trust, London, UK.

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http://dx.doi.org/10.1136/bmj.l93DOI Listing
February 2019

Developmental fluoxetine exposure in zebrafish reduces offspring basal cortisol concentration via life stage-dependent maternal transmission.

PLoS One 2019 21;14(2):e0212577. Epub 2019 Feb 21.

Department of Biology, University of Ottawa, Ottawa, Ontario, Canada.

Fluoxetine (FLX) is a pharmaceutical used to treat affective disorders in humans, but as environmental contaminant also affects inadvertently exposed fish in urban watersheds. In humans and fish, acute FLX treatment and exposure are linked to endocrine disruption, including effects on the reproductive and stress axes. Using the zebrafish model, we build on the recent finding that developmental FLX exposure reduced cortisol production across generations, to determine possible parental and/or life-stage-dependent (age and/or breeding experience) contributions to this phenotype. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0212577PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6383989PMC
February 2019