16,293 results match your criteria Immunology[Journal]


Intestinal overexpression of IL-18 promotes eosinophils-mediated allergic disorders.

Immunology 2019 Feb 19. Epub 2019 Feb 19.

Department of Medicine, Section of Pulmonary Diseases, Tulane Eosinophilic Disorder Center, Tulane University School of Medicine, New Orleans, LA, 70112.

Baseline eosinophils reside in the gastrointestinal tract; however, in several allergic disorders, excessive eosinophils accumulate in the blood as well in the tissues. Recently, we showed in vitro that interleukin (IL)-18 matures and transforms IL-5 generated eosinophils into the pathogenic eosinophils that are detected in human allergic diseases. To examine the role of local induction of IL-18 in promoting eosinophil-associated intestinal disorders. Read More

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http://dx.doi.org/10.1111/imm.13051DOI Listing
February 2019

T17 cells thirsty for calcium.

Authors:
Kirsty Minton

Nat Rev Immunol 2019 Feb 18. Epub 2019 Feb 18.

Nature Reviews Immunology, .

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http://dx.doi.org/10.1038/s41577-019-0138-3DOI Listing
February 2019

At the intersection of DNA damage and immune responses.

Nat Rev Immunol 2019 Feb 18. Epub 2019 Feb 18.

Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY, USA.

DNA damage occurs on exposure to genotoxic agents and during physiological DNA transactions. DNA double-strand breaks (DSBs) are particularly dangerous lesions that activate DNA damage response (DDR) kinases, leading to initiation of a canonical DDR (cDDR). This response includes activation of cell cycle checkpoints and engagement of pathways that repair the DNA DSBs to maintain genomic integrity. Read More

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http://dx.doi.org/10.1038/s41577-019-0135-6DOI Listing
February 2019

Daily Variation in Macrophage Phagocytosis is Clock-independent and Dispensable for Cytokine Production.

Immunology 2019 Feb 18. Epub 2019 Feb 18.

Immunoregulation Section, Autoimmunity Branch, NIAMS, National Institutes of Health, Bethesda, MD, 20892, USA.

Innate immune responses vary in a circadian manner, and more recent investigations aim to understand the underlying molecular mechanisms. Cytokine production varies significantly over the course of a day depending on the time of stimulation by pathogens or Toll-Like Receptor ligands, and multiple signalling pathways linked to the cell-autonomous circadian clock modulate innate immunity. Recognition of foreign material, especially by innate immune cells, engages a myriad of receptors which trigger inflammatory responses, as well as endocytosis and degradation and/or processing for antigen presentation. Read More

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http://dx.doi.org/10.1111/imm.13053DOI Listing
February 2019

Cytokine-mediated communication: a quantitative appraisal of immune complexity.

Nat Rev Immunol 2019 Feb 15. Epub 2019 Feb 15.

Immunodynamics Section, Cancer and Inflammation Program, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA.

Intercellular communication mediated by cytokines is the main mechanism by which cells of the immune system talk to each other. Many aspects of cytokine signalling in the immune system have been explored in great detail at the structural, biophysical, biochemical and cellular levels. However, a systematic understanding of the quantitative rules that govern cytokine-mediated cell-to-cell communication is still lacking. Read More

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http://dx.doi.org/10.1038/s41577-019-0131-xDOI Listing
February 2019

Higher levels of B-cell mutation in the early germinal centres of an inefficient secondary antibody response to a variant Influenza Haemagglutinin.

Immunology 2019 Feb 15. Epub 2019 Feb 15.

Department of Biosciences, University of Exeter, Exeter, EX4 4QD, UK.

Designing improved vaccines against mutable viruses such as Dengue and Influenza would be helped by a better understanding of how the B-cell memory compartment responds to variant antigens. Towards this we have recently shown after secondary immunization of mice with a widely variant Dengue envelope protein, with only 63% amino-acid identity, that IgM+ memory B-cells with few mutations supported an efficient secondary germinal centre (GC) and serum response, superior to a primary response to the same protein. Here, further investigation of memory responses to variant proteins, using more closely related Influenza haemagglutinins (HA), that were 82% identical, produced a variant-induced boost response in the GC dominated by highly mutated B-cells that failed, not efficiently improving serum avidity even in the presence of extra adjuvant, and that was worse than a primary response. Read More

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http://dx.doi.org/10.1111/imm.13052DOI Listing
February 2019
1 Read

The immune regulatory role of neutrophils.

Authors:
Daniel M Altmann

Immunology 2019 Mar;156(3):215-216

Department of Medicine, Hammersmith Hospital, London, UK.

Neutrophils are appreciated to perform a wide range of pro- and anti-inflammatory effector functions in diverse settings. These go far beyond the response to acute infection, encompassing sterile injury, autoimmunity, allergy and tumours. There is growing appreciation of the nuances of their modes of action, especially elucidation of the nature and consequences of NETosis. Read More

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http://dx.doi.org/10.1111/imm.13049DOI Listing

Active immunization with norovirus P particle-based amyloid-β chimeric protein vaccine induces high titers of anti-Aβ antibodies in mice.

BMC Immunol 2019 Feb 12;20(1). Epub 2019 Feb 12.

National Engineering Laboratory for AIDS Vaccine, School of Life Sciences, Jilin University, Changchun, 130012, China.

Background: Active immunotherapy targeting amyloid-β (Aβ) is a promising treatment for Alzheimer's disease (AD). Numerous preclinical studies and clinical trials demonstrated that a safe and effective AD vaccine should induce high titers of anti-Aβ antibodies while avoiding the activation of T cells specific to Aβ.

Results: An untagged Aβ1-6 chimeric protein vaccine against AD based on norovirus (NoV) P particle was expressed in Escherichia coli and obtained by sequential chromatography. Read More

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http://dx.doi.org/10.1186/s12865-019-0289-9DOI Listing
February 2019

Pain killers.

Authors:
Yvonne Bordon

Nat Rev Immunol 2019 Feb 7. Epub 2019 Feb 7.

Nature Reviews Immunology, .

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http://dx.doi.org/10.1038/s41577-019-0137-4DOI Listing
February 2019

T cells feel the heat.

Authors:
Lucy Bird

Nat Rev Immunol 2019 Feb 6. Epub 2019 Feb 6.

Nature Immunology, .

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http://dx.doi.org/10.1038/s41577-019-0134-7DOI Listing
February 2019
1 Read

Sleeping off sickness.

Authors:
Kirsty Minton

Nat Rev Immunol 2019 Feb 6. Epub 2019 Feb 6.

Nature Reviews Immunology, .

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http://www.nature.com/articles/s41577-019-0136-5
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http://dx.doi.org/10.1038/s41577-019-0136-5DOI Listing
February 2019
2 Reads

Gut IELs slow metabolism.

Authors:
Yvonne Bordon

Nat Rev Immunol 2019 Feb 5. Epub 2019 Feb 5.

Nature Reviews Immunology, .

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http://dx.doi.org/10.1038/s41577-019-0133-8DOI Listing
February 2019
1 Read

Butyrate boosts microbicidal macrophages.

Nat Rev Immunol 2019 Feb 5. Epub 2019 Feb 5.

Nature Reviews Immunology, .

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http://dx.doi.org/10.1038/s41577-019-0132-9DOI Listing
February 2019

The aryl hydrocarbon receptor: an environmental sensor integrating immune responses in health and disease.

Nat Rev Immunol 2019 Feb 4. Epub 2019 Feb 4.

Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

The environment, diet, microbiota and body's metabolism shape complex biological processes in health and disease. However, our understanding of the molecular pathways involved in these processes is still limited. The aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor that integrates environmental, dietary, microbial and metabolic cues to control complex transcriptional programmes in a ligand-specific, cell-type-specific and context-specific manner. Read More

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http://dx.doi.org/10.1038/s41577-019-0125-8DOI Listing
February 2019
1 Read

Macrophages as regulators of tumour immunity and immunotherapy.

Nat Rev Immunol 2019 Feb 4. Epub 2019 Feb 4.

Department of Immunology, Department of Breast Oncology, H. Lee Moffitt Cancer Center, Tampa, FL, USA.

Macrophages are critical mediators of tissue homeostasis, with tumours distorting this proclivity to stimulate proliferation, angiogenesis and metastasis. This had led to an interest in targeting macrophages in cancer, and preclinical studies have demonstrated efficacy across therapeutic modalities and tumour types. Much of the observed efficacy can be traced to the suppressive capacity of macrophages, driven by microenvironmental cues such as hypoxia and fibrosis. Read More

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http://dx.doi.org/10.1038/s41577-019-0127-6DOI Listing
February 2019

Breaking the law: unconventional strategies for antibody diversification.

Nat Rev Immunol 2019 Feb 4. Epub 2019 Feb 4.

Sorbonne Universités, UPMC Univ Paris 06, UMR_S 1138, Centre de Recherche des Cordeliers, Paris, France.

Antibodies are essential components of adaptive immunity. A typical antibody repertoire comprises an enormous diversity of antigen-binding specificities, which are generated by the genetic processes of recombination and mutation. Accumulating evidence suggests that the immune system can exploit additional strategies to diversify the repertoire of antigen specificities. Read More

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http://www.nature.com/articles/s41577-019-0126-7
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http://dx.doi.org/10.1038/s41577-019-0126-7DOI Listing
February 2019
6 Reads

Complex dietary-polysaccharide modulates gut immune function and microbiota, and promotes protection from autoimmune diabetes.

Immunology 2019 Feb 3. Epub 2019 Feb 3.

Department of Microbiology and Immunology, College of Medicine, Medical University of South Carolina, Charleston, SC-29425.

Since the dietary supplement and prebiotic value of β-glucan-rich products have been widely recognized and the dietary approaches for modulating autoimmunity have been increasingly explored, we assessed the impact of oral administration of high-pure yeast β-glucan (YBG) on gut immune function, microbiota and type 1 diabetes (T1D) using mouse models. Oral administration of this non-digestible complex polysaccharide caused a Dectin-1-dependent immune response involving increased expression of IL10, retinaldehyde dehydrogenase (Raldh) and pro-inflammatory cytokines in the gut mucosa. YBG-exposed intestinal DCs induced/expanded primarily Foxp3+, IL10+ and IL17+ T cells, ex vivo. Read More

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http://dx.doi.org/10.1111/imm.13048DOI Listing
February 2019

Itaconate: the poster child of metabolic reprogramming in macrophage function.

Nat Rev Immunol 2019 Jan 31. Epub 2019 Jan 31.

Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO, USA.

Itaconate is one of the best examples of the consequences of metabolic reprogramming during immunity. It is made by diverting aconitate away from the tricarboxylic acid cycle during inflammatory macrophage activation. The main reason macrophages exhibit this response currently appears to be for an anti-inflammatory effect, with itaconate connecting cell metabolism, oxidative and electrophilic stress responses and immune responses. Read More

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http://www.nature.com/articles/s41577-019-0128-5
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http://dx.doi.org/10.1038/s41577-019-0128-5DOI Listing
January 2019
3 Reads

Commensal cocktail for CD8s.

Authors:
Lucy Bird

Nat Rev Immunol 2019 Jan 30. Epub 2019 Jan 30.

Nature Reviews Immunology, .

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http://dx.doi.org/10.1038/s41577-019-0130-yDOI Listing
January 2019

Seeing through the parasites' eyes.

Nat Rev Immunol 2019 Jan 30. Epub 2019 Jan 30.

Fundação Oswaldo Cruz, Belo Horizonte, Brazil.

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http://dx.doi.org/10.1038/s41577-019-0129-4DOI Listing
January 2019

Expression of ligands for activating natural killer cell receptors on cell lines commonly used to assess natural killer cell function.

BMC Immunol 2019 Jan 29;20(1). Epub 2019 Jan 29.

Research Institute of the McGill University Health Center, Glen Site, 1001 Décarie Boulevard, Block E, Rm EM3.3238, Montréal, Québec, H4A 3J1, Canada.

Background: Natural killer cell responses to virally-infected or transformed cells depend on the integration of signals received through inhibitory and activating natural killer cell receptors. Human Leukocyte Antigen null cells are used in vitro to stimulate natural killer cell activation through missing-self mechanisms. On the other hand, CEM. Read More

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https://bmcimmunol.biomedcentral.com/articles/10.1186/s12865
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http://dx.doi.org/10.1186/s12865-018-0272-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6352444PMC
January 2019
6 Reads

Sialomucin CD43 regulates T helper type 17 cell intercellular adhesion molecule 1 dependent adhesion, apical migration and transendothelial migration.

Immunology 2019 Jan 28. Epub 2019 Jan 28.

Department of Immunology, Tufts University School of Medicine, Boston, MA, USA.

T helper type 17 lymphocytes (Th17 cells) infiltrate the central nervous system (CNS), induce inflammation and demyelination and play a pivotal role in the pathogenesis of multiple sclerosis. Sialomucin CD43 is highly expressed in Th17 cells and mediates adhesion to endothelial selectin (E-selectin), an initiating step in Th17 cell recruitment to sites of inflammation. CD43 mice have impaired Th17 cell recruitment to the CNS and are protected from experimental autoimmune encephalomyelitis (EAE), the mouse model of multiple sclerosis. Read More

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http://dx.doi.org/10.1111/imm.13047DOI Listing
January 2019
1 Read

Interleukin 35 in Immune-Related Diseases: Protection, or Destruction.

Immunology 2019 Jan 25. Epub 2019 Jan 25.

Department of Medicine, Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.

Interleukin 35 (IL-35) is a recently identified heterodimeric cytokine in the IL-12 family. It consists of an IL-12 subunit α chain (P35) and IL-27 subunit Epstein-Barr virus-induced gene 3 (EBI3) β chain. Unlike the other IL-12 family members, it signals through four unconventional receptors: IL-12Rβ2-IL-27Rα, IL-12Rβ2-IL-12Rβ2, IL-12Rβ2-GP130, and GP130-GP130. Read More

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http://dx.doi.org/10.1111/imm.13044DOI Listing
January 2019
1 Read
3.795 Impact Factor

Adaptive immune responses to primary and secondary dengue virus infections.

Nat Rev Immunol 2019 Jan 24. Epub 2019 Jan 24.

Department of Pathology, Duke University Medical Center, Durham, NC, USA.

Dengue is the leading mosquito-borne viral illness infecting humans. Owing to the circulation of multiple serotypes, global expansion of the disease and recent gains in vaccination coverage, pre-existing immunity to dengue virus is abundant in the human population, and secondary dengue infections are common. Here, we contrast the mechanisms initiating and sustaining adaptive immune responses during primary infection with the immune pathways that are pre-existing and reactivated during secondary dengue. Read More

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http://www.nature.com/articles/s41577-019-0123-x
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http://dx.doi.org/10.1038/s41577-019-0123-xDOI Listing
January 2019
8 Reads

Immunometabolism at the interface between macrophages and pathogens.

Nat Rev Immunol 2019 Jan 24. Epub 2019 Jan 24.

Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, NY, USA.

It is generally regarded that the progression of an infection within host macrophages is the consequence of a failed immune response. However, recent appreciation of macrophage heterogeneity, with respect to both development and metabolism, indicates that the reality is more complex. Different lineages of tissue-resident macrophages respond divergently to microbial, environmental and immunological stimuli. Read More

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http://dx.doi.org/10.1038/s41577-019-0124-9DOI Listing
January 2019

CEACAM1 regulates the IL-6 mediated fever response to LPS through the RP105 receptor in murine monocytes.

BMC Immunol 2019 Jan 23;20(1). Epub 2019 Jan 23.

Department of Molecular Imaging and Therapy, Beckman Research Institute of City of Hope, 1500E Duarte Road, Duarte, CA91010, USA.

Background: Systemic inflammation and the fever response to pathogens are coordinately regulated by IL-6 and IL-1β. We previously showed that CEACAM1 regulates the LPS driven expression of IL-1β in murine neutrophils through its ITIM receptor.

Results: We now show that the prompt secretion of IL-6 in response to LPS is regulated by CEACAM1 expression on bone marrow monocytes. Read More

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http://dx.doi.org/10.1186/s12865-019-0287-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6345024PMC
January 2019
2.481 Impact Factor

Monoclonal antibody against EV71 3D inhibits the polymerase activity of RdRp and virus replication.

BMC Immunol 2019 Jan 22;20(1). Epub 2019 Jan 22.

Mucosal Immunity Research Group, State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, 430071, People's Republic of China.

Background: Enterovirus A 71 (EV71) is a neurotropic virus that may lead to acute flaccid paralysis, encephalitis, cardiopulmonary failure or even death. No vaccine and defensive drug controlling EV71 is currently available, novel and efficient antiviral drug or vaccine is therefore urgently needed. 3D (RNA-dependent RNA polymerase (RdRp)) has been an important target for anti-EV71 drug development. Read More

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http://dx.doi.org/10.1186/s12865-019-0288-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6343263PMC
January 2019
3 Reads

Attenuation of IRF7 activity in local infectious sites of trachea and lung for preventing the development of acute lung injury caused by influenza A virus.

Immunology 2019 Jan 22. Epub 2019 Jan 22.

Department of Molecular Biology in College of Basic Medical Sciences and Institute of Pediatrics in, The First Hospital of Jilin University, Jilin University, Changchun, Jilin, 130021, P.R. China.

The excessive activation of interferon regulatory factor 7 (IRF7) promotes the development of acute lung injury (ALI) caused by influenza A virus (IAV). However, the deficiency of IRF7 increases the susceptibility to deadly IAV infection in both human and mice. To test whether the attenuation rather than the abolishment of IRF7 activity in local infectious sites could alleviate IAV-induced ALI, we established IAV-infected mouse model and trachea/lung tissue culture systems, and designed two IRF7-interfering oligodeoxynucleotides (IRF7-rODNs), IRF7-rODN M1 and IRF7-rODN A1, based on the mouse and human consensus sequences of IRF7 binding sites of Ifna/IFNA genes, respectively. Read More

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http://dx.doi.org/10.1111/imm.13045DOI Listing
January 2019
3 Reads

Differential role of the NLRP3 inflammasome in infection and tumorigenesis.

Immunology 2019 Jan 21. Epub 2019 Jan 21.

Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN, USA.

Dysregulated inflammation is one of the hallmarks of cancer initiation and progression. Emerging evidence indicates that inflammasomes play a central role in regulating immune cell functions in various infections and cancer. Inflammasomes are multimeric complexes consisting of nucleotide-binding oligomerization domain (NOD) -like receptors (NLRs). Read More

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http://doi.wiley.com/10.1111/imm.13046
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http://dx.doi.org/10.1111/imm.13046DOI Listing
January 2019
3 Reads

Comparative analysis of thymic subpopulations during different modes of atrophy identifies the reactive oxygen species scavenger, N-acetyl cysteine, to increase the survival of thymocytes during infection-induced and lipopolysaccharide-induced thymic atrophy.

Immunology 2019 Jan 19. Epub 2019 Jan 19.

Department of Biochemistry, Indian Institute of Science, Bangalore, India.

The development of immunocompetent T cells entails a complex pathway of differentiation in the thymus. Thymic atrophy occurs with ageing and during conditions such as malnutrition, infections and cancer chemotherapy. The comparative changes in thymic subsets under different modes of thymic atrophy and the mechanisms involved are not well characterized. Read More

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http://dx.doi.org/10.1111/imm.13043DOI Listing
January 2019
1 Read
3.795 Impact Factor

Phenotypic and functional stability of leukocytes from human peripheral blood samples: considerations for the design of immunological studies.

BMC Immunol 2019 Jan 18;20(1). Epub 2019 Jan 18.

Centro Internacional de Entrenamiento e Investigaciones Médicas-CIDEIM, Cali, Colombia.

Background: Human peripheral blood mononuclear cells (PBMCs) are extensively used for research of immune cell functions, identification of biomarkers and development of diagnostics and therapeutics for human diseases, among others. The assumption that "old blood samples" are not appropriate for isolation of PBMCs for functional assays has been a dogma in the scientific community. However, partial data on the impact of time after phlebotomy on the quality and stability of human PBMCs preparations impairs the design of studies in which time-controlled blood sampling is challenging such as field studies involving multiple sampling centers/sites. Read More

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http://dx.doi.org/10.1186/s12865-019-0286-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6339328PMC
January 2019
1 Read

Sodium in the microenvironment regulates immune responses and tissue homeostasis.

Nat Rev Immunol 2019 Jan 15. Epub 2019 Jan 15.

Department of Neurology, University of Regensburg, Regensburg, Germany.

During tissue inflammation, immune cells infiltrate the interstitial space of target organs, where they sense and adapt to local environmental stimuli. Such stimuli include not only pathogens but also local factors such as the levels of oxygenation, nutrients and electrolytes. An important electrolyte in this regard is sodium (Na). Read More

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http://www.nature.com/articles/s41577-018-0113-4
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http://dx.doi.org/10.1038/s41577-018-0113-4DOI Listing
January 2019
4 Reads

Containment strategy.

Authors:
Yvonne Bordon

Nat Rev Immunol 2019 Feb;19(2):71

Nature Reviews Immunology, .

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http://dx.doi.org/10.1038/s41577-019-0122-yDOI Listing
February 2019
1 Read

Neuronal itaconate restricts viral infection.

Authors:
Kirsty Minton

Nat Rev Immunol 2019 Feb;19(2):67

Nature Reviews Immunology, .

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http://dx.doi.org/10.1038/s41577-019-0121-zDOI Listing
February 2019
1 Read

DNA-stimulated cell death: implications for host defence, inflammatory diseases and cancer.

Nat Rev Immunol 2019 Jan 15. Epub 2019 Jan 15.

Gene Center and Department of Biochemistry, Ludwig-Maximilians-Universität München, Munich, Germany.

The immune system detects disturbances in homeostasis that occur during infection, sterile tissue damage and cancer. This initiates immune responses that seek to eliminate the trigger of immune activation and to re-establish homeostasis. At the same time, these mechanisms can also play a crucial role in the progression of disease. Read More

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http://www.nature.com/articles/s41577-018-0117-0
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http://dx.doi.org/10.1038/s41577-018-0117-0DOI Listing
January 2019
13 Reads

Organismal immunometabolism: advances in both directions.

Authors:
Diane Mathis

Nat Rev Immunol 2019 Feb;19(2):83-84

Department of Immunology, Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1038/s41577-018-0118-zDOI Listing
February 2019
1 Read

Correlate tumor mutation burden with immune signatures in human cancers.

BMC Immunol 2019 Jan 11;20(1). Epub 2019 Jan 11.

Biomedical Informatics Research Lab, School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing, 211198, China.

Background: Tumor mutation burden (TMB) has been associated with cancer immunotherapeutic response and cancer prognosis. Although many explorations have revealed that high TMB may yield many neoantigens to incite antitumor immune response, a systematic exploration of the correlation between TMB and immune signatures in different cancer types is lacking.

Results: We classified cancer into the lower-TMB subtype and the higher-TMB subtype for each of 32 cancer types based on their somatic mutation data from the Cancer Genome Atlas (TCGA), and compared the expression levels of immune-related genes and gene-sets between both subtypes of cancers in each cancer type. Read More

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https://bmcimmunol.biomedcentral.com/articles/10.1186/s12865
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http://dx.doi.org/10.1186/s12865-018-0285-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6329192PMC
January 2019
5 Reads

Natural killer cell transcriptional control, subsets, receptors and effector function.

Authors:
Daniel M Altmann

Immunology 2019 Feb;156(2):109-110

Department of Medicine, Hammersmith Hospital, London, UK.

There have been considerable advances in characterization of the complexities of natural killer (NK) cell ligand recognition, activation, subsets and effector functions. The nature of the transcription factors that act to define distinctive functional programmes of NK cell subsets are now starting to be clarified as a consequence of studies in knockouts. Importantly, this is being extended to improved understanding of the nature of NK cell memory. Read More

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http://doi.wiley.com/10.1111/imm.13041
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http://dx.doi.org/10.1111/imm.13041DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6329198PMC
February 2019
4 Reads

Corrigendum.

Authors:

Immunology 2019 Feb 26;156(2):213. Epub 2018 Nov 26.

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http://dx.doi.org/10.1111/imm.13014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6328986PMC
February 2019

CAR T cell therapy: inroads to response and resistance.

Nat Rev Immunol 2019 Feb;19(2):73-74

Ernest and Amelia Gallo Family Professor of Pediatrics and Medicine, Stanford University, Stanford, CA, USA.

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http://dx.doi.org/10.1038/s41577-018-0119-yDOI Listing
February 2019
1 Read

Treatment of established TH2 cells with 4μ8c, an inhibitor of IRE1α, blocks IL-5 but not IL-4 secretion.

BMC Immunol 2019 Jan 10;20(1). Epub 2019 Jan 10.

Department of Natural Sciences, Northeastern State University, 3100 New Orleans Street, Broken Arrow, OK, 74014, USA.

Background: T cell activation induces ER stress and upregulates Inositol Requiring Enzyme 1 alpha (IRE1α), an activator of the unfolded protein response (UPR) pathway. Inhibition of IRE1α RNase activity in activated CD4 splenocytes from naïve mice, via treatment of the cells with the commercially available drug 4μ8c upon activation, results in the reduction of the secretion of proteins IL-5, IL-4, and IL-13. Prior to this work, it was unknown if 4μ8c could inhibit TH2 cytokines in established TH2 cells, cells that are crucial in promoting disease in severe asthma. Read More

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https://bmcimmunol.biomedcentral.com/articles/10.1186/s12865
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http://dx.doi.org/10.1186/s12865-018-0283-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6327572PMC
January 2019
7 Reads

21st century natural killers.

Authors:
Cristina M Tato

Nat Rev Immunol 2019 Feb;19(2):69

Chan Zuckerberg Biohub, San Francisco, CA, USA.

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http://dx.doi.org/10.1038/s41577-019-0120-0DOI Listing
February 2019
2 Reads

Novel connections and precision approaches.

Nat Rev Immunol 2019 Feb;19(2):75-76

Joan and Sanford I. Weill Department of Medicine, Division of Gastroenterology, Department of Microbiology and Immunology, and the Jill Roberts Institute for Research in Inflammatory Bowel Disease, Weill Cornell Medicine, Cornell University, New York, NY, USA.

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http://www.nature.com/articles/s41577-018-0114-3
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http://dx.doi.org/10.1038/s41577-018-0114-3DOI Listing
February 2019
6 Reads

Calcium signalling in T cells.

Nat Rev Immunol 2019 Jan 8. Epub 2019 Jan 8.

Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.

Calcium (Ca) signalling is of paramount importance to immunity. Regulated increases in cytosolic and organellar Ca concentrations in lymphocytes control complex and crucial effector functions such as metabolism, proliferation, differentiation, antibody and cytokine secretion and cytotoxicity. Altered Ca regulation in lymphocytes leads to various autoimmune, inflammatory and immunodeficiency syndromes. Read More

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http://www.nature.com/articles/s41577-018-0110-7
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http://dx.doi.org/10.1038/s41577-018-0110-7DOI Listing
January 2019
7 Reads

Human-like NSG mouse glycoproteins sialylation pattern changes the phenotype of human lymphocytes and sensitivity to HIV-1 infection.

BMC Immunol 2019 Jan 7;20(1). Epub 2019 Jan 7.

Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE, 68198, USA.

Background: The use of immunodeficient mice transplanted with human hematopoietic stem cells is an accepted approach to study human-specific infectious diseases such as HIV-1 and to investigate multiple aspects of human immune system development. However, mouse and human are different in sialylation patterns of proteins due to evolutionary mutations of the CMP-N-acetylneuraminic acid hydroxylase (CMAH) gene that prevent formation of N-glycolylneuraminic acid from N-acetylneuraminic acid. How changes in the mouse glycoproteins' chemistry affect phenotype and function of transplanted human hematopoietic stem cells and mature human immune cells in the course of HIV-1 infection are not known. Read More

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http://dx.doi.org/10.1186/s12865-018-0279-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6322283PMC
January 2019
4 Reads
2.481 Impact Factor

Poised plasticity of skin T cells.

Authors:
Lucy Bird

Nat Rev Immunol 2019 Feb;19(2):70-71

Nature Reviews Immunology, .

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http://www.nature.com/articles/s41577-018-0116-1
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http://dx.doi.org/10.1038/s41577-018-0116-1DOI Listing
February 2019
4 Reads

Microglia take centre stage in neurodegenerative disease.

Authors:
Michael T Heneka

Nat Rev Immunol 2019 Feb;19(2):79-80

Department of Neurodegenerative Disease and Geriatric Psychiatry, University of Bonn, Bonn, Germany.

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http://www.nature.com/articles/s41577-018-0112-5
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http://dx.doi.org/10.1038/s41577-018-0112-5DOI Listing
February 2019
15 Reads

Mannose-binding lectin concentrations in people living with HIV/AIDS infected by HHV-8.

BMC Immunol 2019 Jan 3;20(1). Epub 2019 Jan 3.

Virology Division, Laboratory of Immunopathology Keizo Asami (LIKA), Federal University of Pernambuco, Recife, Pernambuco, Brazil.

Background: Mannose-binding lectin (MBL) plays an important role in the innate immune response by activating the complement system via the lectin pathway, and it has been studied in several viral infections; however, the influence of MBL in PLWHA infected with HHV-8 is unknown. The objective of this study was to verify the association of MBL deficient plasma concentrations in HIV/HHV-8 coinfected and HIV monoinfected patients and to correlate these concentrations with HIV viral load and CD4 counts in both groups.

Results: This was an analytical study of case-controls consisting of PLWHA monitored at the medical outpatient of Infectious and Parasitic Diseases of the clinical hospital in the Federal University of Pernambuco. Read More

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https://bmcimmunol.biomedcentral.com/articles/10.1186/s12865
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http://dx.doi.org/10.1186/s12865-018-0284-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6318849PMC
January 2019
6 Reads

Deciphering the gut-brain link in NEC.

Nat Rev Immunol 2019 Feb;19(2):70-71

Nature Reviews Immunology, .

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http://dx.doi.org/10.1038/s41577-018-0115-2DOI Listing
February 2019
1 Read

Systems-level patterns emerge.

Authors:
Petter Brodin

Nat Rev Immunol 2019 Feb;19(2):87-88

Science for Life Laboratory, Department of Women's and Children's Health, Karolinska Institutet, Stockholm, Sweden.

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http://dx.doi.org/10.1038/s41577-018-0106-3DOI Listing
February 2019
1 Read