132,670 results match your criteria Immunological Reviews [Journal]


Recombinant Staphylococcal Antigen-F (r-ScaF), a novel vaccine candidate against methicillin resistant Staphylococcus aureus infection: Potency and efficacy studies.

Microb Pathog 2018 Dec 3. Epub 2018 Dec 3.

Department of Pathobiology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran. Electronic address:

Staphylococcus aureus is a human commensal and pathogen, its clinical importance is exacerbated by the spread of multi-drug resistant strains. The potential future failure of antibiotic therapy necessitates the development of novel control regimes, including new immunotherapeutic approaches. S. Read More

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December 2018

Short communication: Targeted proteomic analysis detects acute T cell-mediated kidney allograft rejection in belatacept-treated patients.

Ther Drug Monit 2018 Dec 4. Epub 2018 Dec 4.

Departments of Internal Medicine, Division of Nephrology and Transplantation and.

Background: There is an unmet need for reliable minimally invasive diagnostic biomarkers for immunological allograft monitoring and for the detection of acute kidney transplant rejection. Here, targeted proteomic analysis was applied to compare 92 proteins in sera of belatacept-treated patients who had biopsy-proven, acute T cell-mediated rejection (aTCMR) with patients without aTCMR.

Methods: Proximity extension immunoassay (PEA) was used to measure 92 inflammation-related protein concentrations in the pre-rejection and rejection sera of 11 patients with aTCMR and 9 patients without aTCMR. Read More

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December 2018
1 Read

Everything in its right place: resident memory CD8+ T cell immunosurveillance of HIV infection.

Curr Opin HIV AIDS 2018 Dec 4. Epub 2018 Dec 4.

Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.

Purpose Of Review: To introduce emerging concepts in tissue resident CD8 T cell immunosurveillance and their relevance to control HIV infection.

Recent Findings: It is well appreciated that HIV preferentially infects and persists in CD4 T cells located in gut and in lymphoid tissue, yet the majority of known immunological correlates of HIV control are derived from peripheral blood. Instead, tissue-based immunological surveillance likely dictates the course of infection. Read More

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December 2018
1 Read

The dynamics of individual whey protein concentrations in cows' mammary secretions during the colostral and early lactation periods.

J Dairy Res 2018 Dec 6:1-6. Epub 2018 Dec 6.

Departamento de Medicina Veterinária, Faculdade de Zootecnia e Engenharia de Alimentos,Universidade de São Paulo,Sao Paulo,Brazil.

The bovine whey consists of more than 200 different types of proteins, of which β-lactoglobulin, α-lactalbumin, serum albumin, immunoglobulins and lactoferrin predominate. However, their concentrations are not stable due to the existence of protein dynamics during a transition from colostrum secretion to mature milk. To evaluate the dynamics of whey proteins of Jersey cows during a colostral phase and first month of lactation and an influence of the number of lactations, 268 milk samples from 135 Jersey cows were selected through a clinical evaluation. Read More

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December 2018

Chinese society of cardiology expert consensus statement on the diagnosis and treatment of adult fulminant myocarditis.

Sci China Life Sci 2018 Dec 3. Epub 2018 Dec 3.

Department of Cardiology, Changzheng Hospital, The Second Military Medical University, Shanghai, 200003, China.

Fulminant myocarditis is primarily caused by infection with any number of a variety of viruses. It arises quickly, progresses rapidly, and may lead to severe heart failure or circulatory failure presenting as rapid-onset hypotension and cardiogenic shock, with mortality rates as high as 50%-70%. Most importantly, there are no treatment options, guidelines or an expert consensus statement. Read More

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December 2018
2 Reads

Immunoscore System for Predicting Clinical Outcome of Metastatic Renal Cell Carcinoma Patients Treated with Tyrosine Kinase Inhibitors.

J Cancer 2018 18;9(22):4099-4107. Epub 2018 Oct 18.

Department of Urology, Zhongshan Hospital, Fudan University, Shanghai 200032, China.

We conducted this study to determine whether immunoscore system (IS) predicts survival in patients with metastatic renal cell carcinoma (mRCC). A total of 218 mRCC patients treated with sunitinib or sorafenib in Zhongshan Hospital, Fudan University were recruited during 2007-2017, retrospectively. CD8, CD4, Treg, PD-1 and PD-L1 expression were evaluated by immunohistochemical staining of paraffin embedded slide. Read More

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October 2018
2 Reads

Host Adaptive Immune Status Regulates Expression of the Schistosome AMP-Activated Protein Kinase.

Front Immunol 2018 21;9:2699. Epub 2018 Nov 21.

Department of Microbiology and Immunology, F. Edward Hébert School of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD, United States.

Schistosomes exhibit profound developmental adaptations in response to the immune status of their mammalian host, including significant attenuation of parasite growth, development and reproduction in response to deficits in host adaptive immunity. These observations led us to hypothesize that schistosomes regulate the utilization of energy resources in response to immunological conditions within the host. To test this hypothesis, we identified and characterized the AMP-activated protein kinase (AMPK), a heterotrimeric enzyme complex that is central to regulating energy metabolism at the cellular and organismal level in eukaryotes. Read More

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November 2018

Immunization of Experimental Dogs With Salivary Proteins From , Using DNA and Recombinant Canarypox Virus Induces Immune Responses Consistent With Protection Against .

Front Immunol 2018 16;9:2558. Epub 2018 Nov 16.

Fundação Oswaldo Cruz, Instituto Gonçalo Moniz, Salvador, Brazil.

Metacyclic promastigotes are transmitted by sand flies that inject parasites and saliva into the host's skin. Previous studies have demonstrated that DNA plasmids encoding salivary proteins LJM17 and LJL143, when used to immunize dogs, resulted in a systemic and local Th1 cell-mediated immunity that interfered in parasite survival . Here we evaluated the ability of these same salivary antigens to induce anti- immunity and to confer protection by immunizing dogs using a novel vaccination strategy more suitable for use in the field. Read More

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November 2018
4 Reads

Sex differences of inflammation in target organs, induced by intraperitoneal injection of lipopolysaccharide, depend on its dose.

J Inflamm Res 2018 8;11:431-445. Epub 2018 Nov 8.

Department of Pathology, Federal State Budgetary Institution "Science Research Institute of Human Morphology", Moscow, Russia.

Purpose: The aim of our research was to study sex differences and the severity of inflammatory changes in target organs and the peculiarities of immunological disorders when low and high doses of lipopolysaccharide (LPS) were administered to rats.

Methods: Male and female 2- to 3-month-old Wistar rats (200-250 g) were injected intraperitoneally with LPS in one of two doses: 1.5 or 15 mg/kg. Read More

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November 2018
1 Read

Robust adaptive immune response against infection marked by low parasitemia in a murine model of sickle cell disease.

Blood Adv 2018 Dec;2(23):3462-3478

Laboratory of Complement Biology and.

The intraerythrocytic parasite is the number 1 cause of transfusion-transmitted infection and can induce serious, often life-threatening complications in immunocompromised individuals including transfusion-dependent patients with sickle cell disease (SCD). Despite the existence of strong long-lasting immunological protection against a second infection in mouse models, little is known about the cell types or the kinetics of protective adaptive immunity mounted following infection, especially in infection-prone SCD that are thought to have an impaired immune system. Here, we show, using a mouse infection model, that infected wild-type (WT) mice mount a very strong adaptive immune response, characterized by (1) coordinated induction of a robust germinal center (GC) reaction; (2) development of follicular helper T (T) cells that comprise ∼30% of splenic CD4 T cells at peak expansion by 10 days postinfection; and (3) high levels of effector T-cell cytokines, including interleukin 21 and interferon γ, with an increase in the secretion of antigen (Ag)-specific antibodies (Abs). Read More

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December 2018

Immunological analysis of phase II glioblastoma dendritic cell vaccine (Audencel) trial: immune system characteristics influence outcome and Audencel up-regulates Th1-related immunovariables.

Acta Neuropathol Commun 2018 Dec 5;6(1):135. Epub 2018 Dec 5.

Activartis Biotech GmbH, Wilhelminenstraße 91/IIf, 1160, Vienna, Austria.

Audencel is a dendritic cell (DC)-based cellular cancer immunotherapy against glioblastoma multiforme (GBM). It is characterized by loading of DCs with autologous whole tumor lysate and in vitro maturation via "danger signals". The recent phase II "GBM-Vax" trial showed no clinical efficacy for Audencel as assessed with progression-free and overall survival in all patients. Read More

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December 2018
1 Read

Tumour associated lymphocytes in the pleural effusions of patients with mesothelioma express high levels of inhibitory receptors.

BMC Res Notes 2018 Dec 5;11(1):864. Epub 2018 Dec 5.

National Centre for Asbestos Related Diseases, School of Medicine and Pharmacology, University of Western Australia, Nedlands, Western Australia, Australia.

Objective: Pleural effusion (PE) is a common feature of malignant pleural mesothelioma. These effusions typically contain lymphocytes and malignant cells. We postulated that the PE would be a source of lymphocytes for analysis of tumor immune milieu. Read More

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December 2018

Recurrent Implantation Failure-update overview on etiology, diagnosis, treatment and future directions.

Reprod Biol Endocrinol 2018 Dec 5;16(1):121. Epub 2018 Dec 5.

Department of Obstetrics and Gynecology, Chaim Sheba Medical Center, Tel-Hashomer, 52621, Ramat Gan, Israel.

Recurrent implantation failure (RIF) refers to cases in which women have had three failed in vitro fertilization (IVF) attempts with good quality embryos. The definition should also take advanced maternal age and embryo stage into consideration. The failure of embryo implantation can be a consequence of uterine, male, or embryo factors, or the specific type of IVF protocol. Read More

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December 2018

Immunological effects of the intraparenchymal administration of allogeneic and autologous adipose-derived mesenchymal stem cells after the acute phase of middle cerebral artery occlusion in rats.

J Transl Med 2018 Dec 5;16(1):339. Epub 2018 Dec 5.

Department of Pediatrics, Navy General Hospital, No. 6, Fucheng Road, Haidian District, Beijing, 100048, China.

Background: Adipose-derived mesenchymal stem cell (ADMSC) therapy can promote recovery from cerebral ischemia; however, more information regarding appropriate sources of ADMSCs is required. This study was aimed at analyzing the immunogenicity of rat ADMSCs by comparing the immunological effects of intraparenchymal administration of allogeneic ADMSCs (allo-ADMSCs) and autologous ADMSCs (auto-ADMSCs) after the acute phase of middle cerebral artery occlusion (MCAO) in rats.

Methods: Allo- or auto-ADMSCs from rats (1 × 10 cells) were transplanted into Lewis rats 8 days post MCAO. Read More

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December 2018

Suspension culture of Marek's disease virus and evaluation of its immunological effects.

Avian Pathol 2018 Dec 6:1-35. Epub 2018 Dec 6.

a College of Veterinary Medicine , South China Agricultural University , Guangzhou 510642 , China.

Marek's disease virus (MDV) is a cell-associated α-herpesvirus of chickens. It is difficult to perform its complete suspension culture. Therefore, MDV vaccines are currently produced using adherent primary chicken embryo fibroblasts and on a large scale is labor intensive and costly. Read More

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December 2018

Pseudane-VII Regulates LPS-Induced Neuroinflammation in Brain Microglia Cells through the Inhibition of iNOS Expression.

Molecules 2018 Dec 4;23(12). Epub 2018 Dec 4.

Department of Life Science, Immunology Research Lab, BK21-plus Research Team for Bioactive Control Technology, College of Natural Sciences, Chosun University, Dong-gu, Gwangju 61452, Korea.

We previously isolated pseudane-VII from the secondary metabolites of sp. M2 in marine water, and demonstrated its anti-inflammatory efficacy on macrophages. However, the molecular mechanism by which pseudane-VII suppresses neuroinflammation has not yet been elucidated in brain microglia. Read More

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December 2018
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Simple and Novel Assay of the Host-Guest Complexation of Homocysteine with Cucurbit[7]uril.

J Microbiol Biotechnol 2018 Nov 28. Epub 2018 Nov 28.

Department of Applied Chemistry, Kumoh National Institute of Technology, Gumi 39177, Korea.

This paper introduces three ways to determine host-guest complexation of cucurbit[7]uril (CB[7]) with homocysteine (Hcy). After preincubating Hcy and cysteine (Cys) with CB[7], Ellman's reagent (DTNB) was used to detect Hcy and Cys. Only Cys reacted with DTNB and Hcy gave a retarded color change. Read More

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November 2018

Sublingual allergen immunotherapy with a liquid birch pollen product in seasonal allergic rhinoconjunctivitis with/without asthma.

J Allergy Clin Immunol 2018 Nov 30. Epub 2018 Nov 30.

HAL Allergy BV, Leiden, The Netherlands.

Background: Sublingual allergen immunotherapy (SLIT) has been demonstrated to be both clinical efficacious and safe. However, in line with the current regulatory guidance from the European Medicines Agency, allergen immunotherapy (AIT) products must demonstrate their efficacy and safety in pivotal, phase III trials for registration.

Objective: To investigate the efficacy and safety of sublingual high-dose liquid birch pollen extract (40,000 AUN/ml) in birch pollen allergic adult patients. Read More

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November 2018

Positive Luminex and negative flow cytometry in kidney transplantation: a systematic review and meta-analysis.

Nephrol Dial Transplant 2018 Nov 30. Epub 2018 Nov 30.

Faculty of Health and Life Science, Institute of Learning and Teaching, University of Liverpool, Liverpool, UK.

The presence of pre-formed donor-specific antibodies (DSAs) in kidney transplantation is associated with worse overall outcomes compared with DSA-negative transplantation. A positive complement-dependant cytotoxic crossmatch presents a high immunological risk, while a negative flow cytometry crossmatch is at the lower end of the risk spectrum. Yet, the presence of low-level DSA detected by Luminex alone, that is, positive Luminex and negative flow (PLNF) cytometry crossmatch lacks robust scientific exploration. Read More

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November 2018
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Tumor necrosis factor-driven cell death in donor organ as a barrier to immunological tolerance.

Curr Opin Organ Transplant 2018 Nov 30. Epub 2018 Nov 30.

Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, USA.

Purpose Of Review: Regulated cell death (RCD) is likely to play a role in organ rejection but it is unclear how it may be invoked. A well-known trigger of regulated cell death is tumor necrosis factor-alpha (TNF), which activates both caspase-dependent apoptosis and caspase-independent necroptosis. TNF is best known as a pro-inflammatory cytokine because it activates NFκB and MAPK signaling to induce expression of pro-inflammatory genes. Read More

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November 2018

Measuring alloantibodies: a matter of quantity and quality.

Curr Opin Organ Transplant 2018 Nov 30. Epub 2018 Nov 30.

Regional HLA Laboratory, Laboratory Medicine Program, University Health Network.

Purpose Of Review: This review is intended to describe both the usefulness and limitations of mean fluorescence intensity (MFI) as a semiquantitative measure for assessing the presence, relative strength, and clinical impact of human leukocyte antigen (HLA) alloantibodies, as well as the other qualitative features of antibodies that are important considerations in assessing patient risk.

Recent Findings: Using MFI as a quantitative measure is complicated by procedural variation between HLA laboratories. Standardized serum manipulations such as EDTA treatment or serum dilution results in better definition of relationships between MFI and antibody titer or complement activation, bringing the HLA community closer to consensus regarding strategies for defining positivity. Read More

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November 2018

Rush desensitization with a single antigen induces subclinical activation of mast cells and protects against bystander challenge in dually sensitized mice.

Clin Exp Allergy 2018 Dec 2. Epub 2018 Dec 2.

Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Road, Bethesda, MD, 20814, United States.

Background: Rush desensitization can provide short-term tolerance to individuals who are allergic to certain medications in instances where other therapeutic interventions are limited. While rush DS is typically successful in preventing adverse type I hypersensitivity reactions, the mechanism of allergic protection remains unknown. Given the rise in prevalence of individuals displaying multiple allergies, understanding the impact of rush DS on "bystander" allergens, or additional allergens to which an individual is sensitized, could help inform clinical recommendations. Read More

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December 2018

Impact of immune-related adverse events on survival in patients with advanced non-small cell lung cancer treated with nivolumab: long-term outcomes from a multi-institutional analysis.

J Cancer Res Clin Oncol 2018 Dec 1. Epub 2018 Dec 1.

Medical Oncology, Santa Maria della Misericordia Hospital, Piazzale Menghini, 06129, Perugia, Italy.

Purpose: Immune-checkpoint inhibitors (ICIs) represent the standard of care for platinum-pretreated advanced non-small cell lung cancer patients. Patients treated with ICIs may experience immune-related adverse events (irAEs), that might reflect antitumor responses. Here we evaluated nivolumab efficacy according to the development of irAEs. Read More

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December 2018

Immunological status of chronically exposed persons with increased level of TCR mutations.

Radiat Environ Biophys 2018 Dec 1. Epub 2018 Dec 1.

South Ural State Medical University, Chelyabinsk, Russia.

Dose- and dose rate-dependent increase in the number of СD3СD16CD56-lymphocytes and lysosomal activity of neutrophils was noted in peripheral blood of the Techa riverside residents with increased level of TCR gene-mutated T lymphocytes long after chronic exposure of predominantly red bone marrow (mean exposure dose was 0.89 ± 0.09 Gy, individual dose range was 0. Read More

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December 2018

Immunological modulation following bone marrow-derived mesenchymal stromal cells and Th17 lymphocyte co-cultures.

Inflamm Res 2018 Nov 30. Epub 2018 Nov 30.

Osteoarthritis Research Unit, Department of Medicine, University of Montreal Hospital Research Center (CRCHUM), 900 rue Saint-Denis, R11.424, Montreal, QC, H2X 0A9, Canada.

Objective And Design: The objective of the study is to uncover the influence of human bone marrow-derived mesenchymal stem cells (BM-MSCs) on the generation of Th17 lymphocytes in co-cultures of both BM-MSCs and T cells.

Materials And Methods: BM-MSCs, characterized according to the international society for cellular therapy (ISCT) criteria, were co-cultured with T cells isolated from peripheral blood. The expression levels of IL-17 receptor, RORγt and IL-23 receptor were evaluated using flow cytometry. Read More

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November 2018

Immunometabolism: Another Road to Sepsis and Its Therapeutic Targeting.

Authors:
Vijay Kumar

Inflammation 2018 Dec 1. Epub 2018 Dec 1.

Children's Health Queensland Clinical Unit, Department of Paediatrics and Child Care, School of Clinical Medicine, Mater Research, Faculty of Medicine, University of Queensland, ST Lucia, Brisbane, QLD, 4078, Australia.

Sepsis is a major health problem all over the world. Despite its existence since the time of Hippocrates (470 BC), sepsis is still a serious medical problem for physicians working in both pediatric and adult intensive care units. The most current US FDA-approved drug called recombinant human activated protein C or Drotrecogin-α is also failed in clinical trials and showed similar effects as placebo. Read More

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December 2018

The Early Phases of Ankylosing Spondylitis: Emerging Insights From Clinical and Basic Science.

Front Immunol 2018 16;9:2668. Epub 2018 Nov 16.

Section of Musculoskeletal Disease, Leeds Institute of Molecular Medicine, University of Leeds, NIHR Leeds Musculoskeletal Biomedical Research Unit, Chapel Allerton Hospital, Leeds, United Kingdom.

In our paper, we discuss how the early phases of ankylosing spondylitis (AS) are linked to peri-firbocartilagenous osteitis in the sacroiliac joint and entheseal bone related anchoring sites. This skeletal proclivity is linked to an abnormal immunological response to skeletal biomechanical stress and associated microdamage. A key event in the early stages of AS appears to be the association with subclinical Crohn's-like colitis with this gut inflammation being pivotal to the osteitis reaction. Read More

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November 2018
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Autologous Hematopoietic Stem Cell Transplantation for Autoimmune Diseases: From Mechanistic Insights to Biomarkers.

Front Immunol 2018 16;9:2602. Epub 2018 Nov 16.

Center for Cell-based Therapy, Regional Hemotherapy Center of Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, Brazil.

Phase I/II clinical trials of autologous hematopoietic stem cell transplantation (AHSCT) have led to increased safety and efficacy of this therapy for severe and refractory autoimmune diseases (AD). Recent phase III randomized studies have demonstrated that AHSCT induces long-term disease remission in most patients without any further immunosuppression, with superior efficacy when compared to conventional treatments. Immune monitoring studies have revealed the regeneration of a self-tolerant T and B cell repertoire, enhancement of immune regulatory mechanisms, and changes toward an anti-inflammatory milieu in patients that are responsive to AHSCT. Read More

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November 2018
2 Reads

Marginal Zone B Cells Induce Alloantibody Formation Following RBC Transfusion.

Front Immunol 2018 16;9:2516. Epub 2018 Nov 16.

Department of Laboratory Medicine and Pathology, Center for Transfusion Medicine and Cellular Therapies, Emory University School of Medicine, Atlanta, GA, United States.

Red blood cell (RBC) alloimmunization represents a significant immunological challenge for some patients. While a variety of immune constituents likely contribute to the initiation and orchestration of alloantibodies to RBC antigens, identification of key immune factors that initiate alloantibody formation may aid in the development of a therapeutic modality to minimize or prevent this process. To define the immune factors that may be important in driving alloimmunization to an RBC antigen, we determined the specific immune compartment and distinct cells that may initially engage transfused RBCs and facilitate subsequent alloimmunization. Read More

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November 2018

Tumor-infiltrating Immune Cells in H&E-stained Sections of Colorectal Cancer Tissue as a Reasonable Immunological Biomarker.

Anticancer Res 2018 Dec;38(12):6721-6727

Department of Surgical Oncology, Osaka City University Graduate School of Medicine, Osaka, Japan.

Background: The density of tumor-infiltrating lymphocytes has been reported to reflect the antitumor immune status, and many reports have shown that tumor-infiltrating CD8 and total T-lymphocytes may be strong prognostic biomarkers in colorectal cancer. We previously reported that the density of tumor-infiltrating immune cells in hematoxylin and eosin (H&E)-stained sections may be an easily available prognostic biomarker. However, it remains unclear whether the density of tumor-infiltrating immune cells in H&E-stained sections accurately reflects the antitumor immune status. Read More

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December 2018
1 Read

A high throughput bead-based affinity assay enables analysis of genital protein signatures in women at risk of HIV infection.

Mol Cell Proteomics 2018 Nov 30. Epub 2018 Nov 30.

Karolinska Institutet, Sweden.

Women at high risk of HIV infection, including sex workers and those with active genital inflammation, have molecular signatures of immune activation and epithelial barrier remodeling in samples of their genital mucosa. These alterations in the local immunological milieu are likely to impact HIV susceptibility. We here analyze host genital protein signatures in HIV uninfected women, with high frequency of condom use, living in HIV-serodiscordant relationships. Read More

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November 2018
2 Reads

Thinking outside the cereal box: non-carbohydrate routes for dietary manipulation of the gut microbiota.

Appl Environ Microbiol 2018 Nov 30. Epub 2018 Nov 30.

Department of Human Evolutionary Biology, Harvard University, Cambridge, MA 02138.

The gut microbiota is a diverse and dynamic ecological community that is increasingly recognized to play important roles in host metabolic, immunological, and behavioral functioning. As such, identifying new routes for manipulating the microbiota may provide valuable additional methods for improving host health. Dietary manipulations and prebiotic supplementation are active targets of research for altering the microbiota, but, to date, this work has disproportionately focused on carbohydrates. Read More

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November 2018

PTEN Hamartoma Tumor Syndrome and Immune Dysregulation.

Transl Oncol 2018 Nov 29;12(2):361-367. Epub 2018 Nov 29.

Department of Human Genetics, Radboud University Medical Center, Geert Grooteplein Zuid 10, 6525, GA, Nijmegen, The Netherlands; Radboud Institute for Molecular Life Sciences, Geert Grooteplein Zuid 28, 6525, GA, Nijmegen, The Netherlands. Electronic address:

Carriers of a pathogenic germline mutations in the PTEN gene, a well-known tumor suppressor gene, are at increased risk of multiple benign and malignant tumors, e.g. breast, thyroid, endometrial and colon cancer. Read More

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November 2018
1 Read

State-associated changes in longitudinal [F]-PBR111 TSPO PET Imaging of psychosis patients: evidence for the accelerated ageing hypothesis?

Brain Behav Immun 2018 Nov 29. Epub 2018 Nov 29.

Collaborative Antwerp Psychiatric Research Institute, Faculty of Medicine and Health Sciences, University of Antwerp, Antwerp, Belgium; University Department of Psychiatry, Campus Duffel, Duffel, Belgium.

Objective: To determine whether state-associated changes in microglial activity, measured with translocator-protein positron emission tomography (TSPO PET), can be identified in psychosis patients through longitudinal evaluation of their regional tracer uptake over the clinical course from acute psychosis to post-treatment follow-up, and comparison to healthy controls. We also evaluated the relation between tracer uptake, clinical symptoms and peripheral immunological markers.

Method: Second-generation radioligand [F]-PBR111 TSPO PET-CT was used for longitudinal dynamic imaging in 14 male psychosis patients and 17 male age-matched healthy control subjects. Read More

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November 2018

A new chemotherapeutic approach using doxorubicin simultaneously with geopropolis favoring monocyte functions.

Life Sci 2018 Nov 29. Epub 2018 Nov 29.

São Paulo State University (UNESP), Institute of Biosciences, Botucatu, Brazil. Electronic address:

Aims: Chemotherapy has been widely used to treat cancer although it may affect non-target cells involved in the immune response. This work aimed at elucidating whether the chemotherapeutic agent doxorubicin in combination with geopropolis produced by Melipona fasciculata Smith could affect nontumor immune cells, evaluating their immunomodulatory effects on human monocytes.

Main Methods: Cell viability, expression of cell markers (HLA-DR, TLR-2, TLR-4, C80 and CD40), cytokine production (TNF-α, IL-1β, IL-6 and IL-10), intracellular pathways (NF-κB and autophagy), the microbicidal activity of monocytes and hydrogen peroxide (HO) production were analyzed. Read More

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November 2018

Causal relationship between immunological responses and adverse reactions following vaccination.

Authors:
Tetsuo Nakayama

Vaccine 2018 Nov 29. Epub 2018 Nov 29.

Kitasato Institute for Life Sciences, Laboratory of Viral Infection, 5-9-1 Shirokane Minato-ku, Tokyo 108-8641, Japan. Electronic address:

Vaccine adverse events and controversial safety issues have occurred in recent decades in Japan: aseptic meningitis following the measles-mumps-rubella combined vaccine (MMR), anaphylaxis after immunization with live virus vaccines and inactivated split influenza vaccine, an increased incidence of febrile illness following the simultaneous administration of inactivated vaccines, and chronic pain with neurological illness after immunization with the human papilloma virus vaccine (HPV). Vaccine adverse events are a matter of concern for the public as well as general practitioners; some are within the range of assumptions that adverse reactions after live attenuated vaccines are related to the nature of their parental wild-type viruses. Vaccines stimulate the innate immunity of host immunological defense mechanisms and induce the development of specific acquired immunity. Read More

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November 2018

Early-Life Formation of the Microbial and Immunological Environment of the Human Airways.

Cell Host Microbe 2018 Nov 19. Epub 2018 Nov 19.

Service de Pneumologie, Centre Hospitalier Universitaire Vaudois (CHUV), 1066 Epalinges, Switzerland; Department of Immunology and Pathology, Central Clinical School, Monash University, Melbourne, VIC 3004, Australia. Electronic address:

Crosstalk between immune cells and the microbiota in mucosal tissues can set an individual on a trajectory toward health or disease. Little is known about these early-life events in the human respiratory tract. We examined bacterial colonization and immune system maturation in the lower airways over the first year of life. Read More

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November 2018
2 Reads

Boer goats appear to lack a functional IgA and eosinophil response against natural nematode infection.

Vet Parasitol 2018 Dec 22;264:18-25. Epub 2018 Oct 22.

Institute of Biodiversity, Animal Health and Comparative Medicine, University of Glasgow, Bearsden Road, Glasgow G61 1QH, United Kingdom; Department of Animal, Plant and Soil Sciences, AgriBio, 5 Ring Road, Bundoora, Victoria 3086, Melbourne, Australia.

Gastrointestinal nematode infection is one of the major diseases affecting small ruminants. Although some breeds of goats are quite resistant, many breeds of goats are relatively susceptible. This study used a combined parasitological, immunological, bioinformatic and statistical approach to examine the role of goat IgA and eosinophils in protection against Teladorsagia circumcincta. Read More

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December 2018

Heterogeneous early immune responses to the S. aureus EapH2 antigen induced by gastrointestinal tract colonisation impact the response to subsequent vaccination.

Vaccine 2018 Nov 28. Epub 2018 Nov 28.

Jenner Institute, University of Oxford, Centre for Cellular and Molecular Physiology, Oxford, UK. Electronic address:

Introduction: S. aureus is a pathogen to which individuals are exposed shortly after birth, with immune responses to S. aureus increasing during childhood. Read More

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November 2018
1 Read

Comparative proteomics identified immune response proteins involved in response to vaccination with heat-inactivated Mycobacterium bovis and mycobacterial challenge in cattle.

Vet Immunol Immunopathol 2018 Dec 29;206:54-64. Epub 2018 Oct 29.

SaBio, Instituto de Investigación en Recursos Cinegéticos IREC CSIC-UCLM-JCCM, Ronda de Toledo s/n, 13005 Ciudad Real, Spain; Department of Veterinary Pathobiology, Center for Veterinary Health Sciences, Oklahoma State University, Stillwater, OK 74078, USA.

There is an imperative need for effective control of bovine tuberculosis (BTB) on a global scale and vaccination of cattle may prove to be pivotal in achieving this. The oral and parenteral use of a heat-inactivated Mycobacterium bovis (M. bovis) vaccine has previously been found to confer partial protection against BTB in several species. Read More

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December 2018

Immunological responses of European badgers (Meles Meles) to infection with Mycobacterium bovis.

Comp Immunol Microbiol Infect Dis 2018 Dec 24;61:9-15. Epub 2018 Sep 24.

Animal and Plant Health Agency, Woodham Lane, New Haw, KT15 3NB, United Kingdom. Electronic address:

Mycobacterium bovis is the main cause of bovine tuberculosis and its eradication is proving difficult in many countries because of wildlife reservoirs, including European badgers (Meles meles) in the UK Ireland. Following the development of badger specific immunological reagents, many studies have shown that some aspects of the cellular and serological immune responses of badgers to virulent M. bovis and the attenuated M. Read More

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December 2018
1 Read

Immunomodulatory effects of probiotics: Can they be used to treat allergies and autoimmune diseases?

Maturitas 2019 Jan 12;119:25-38. Epub 2018 Nov 12.

Institute for Health and Sport, Victoria University, Melbourne, Australia. Electronic address:

As a person ages, physiological, immunological and gut microbiome changes collectively result in an array of chronic conditions. According to the 'hygiene hypothesis' the increasing prevalence of immune-mediated disorders may be related to intestinal dysbiosis, leading to immune dysfunction and associated conditions such as eczema, asthma, allergies and autoimmune diseases. Beneficial probiotic bacteria can be utilized by increasing their abundance within the gastrointestinal lumen, which in turn will modulate immune cells, such as, T helper (Th)-1, Th2, Th17, regulatory T (Treg) cells and B cells, which have direct relevance to human health and the pathogenesis of immune disorders. Read More

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January 2019

Kidney transplantation in systemic lupus erythematosus: Outcomes and prognosis.

Med Clin (Barc) 2018 Nov 27. Epub 2018 Nov 27.

Servicio de Nefrología, Instituto Ramón y Cajal de Investigación Sanitaria (IRYCIS), Hospital Universitario Ramón y Cajal, Madrid, España; Red de Investigación Renal (REDinREN), Madrid, España.

Introduction: The outcome and prognosis of systemic lupus erythematosus (SLE) in long-term kidney transplantation (KT) is variable. The objective of this study was to analyse the survival of the graft and the patient, comparing rates with a control group (primary glomerulonephritis [PGN]).

Materials And Methods: Forty-three patients receiving a KT with diagnosis of lupus nephritis (LN) and 367 patients with PGN were compared between January 1980 and December 2014. Read More

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November 2018

Probable reinfection with Legionella pneumophila - A case report.

Int J Hyg Environ Health 2018 Nov 27. Epub 2018 Nov 27.

Robert Koch Institute, Seestr. 10, Berlin, Germany. Electronic address:

In Germany community-acquired Legionnaires' disease is usually caused by the species Legionella pneumophila. Recurrent cases of Legionnaires' disease are rarely reported and are due either to a second infection (reinfection) or a relapse of a previous case. We report a case of recurrent Legionnaires' disease in an 86-year-old female patient infected with Legionella pneumophila serogroup 1, monoclonal antibody-subtype Knoxville, sequence type unknown. Read More

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November 2018

[Characteristics of CD180 Expression and Its Diagnostic Value in B Cell Chronic Lymphoproliferative Disorders].

Zhongguo Shi Yan Xue Ye Xue Za Zhi 2018 Dec;26(6):1811-1815

Shanghai Institute of Hematology,Ruijin Hospital Affiliated Shanghai Jiaotong University School of

Objective: To investigate the charactcristics of CD180 expression and differentiation diagnostic value in B cell chronic lymphoproliferative disorders (B-CLPD) through detecting the mean fluorescence intensity(MFI)of CD180 in different sub types of B-CLPD,using multiparameter flow cytometry (FCM).

Methods: The CD180 MFI of malignant B cells in 178 patients with B-CLPD was detected by FCM. The level of CD180 MFI in various types of B-CLPD was compared to the normal control group. Read More

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December 2018
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Dendritic cell-expressed common gamma-chain recruits IL-15 for trans-presentation at the murine immunological synapse.

Wellcome Open Res 2018 17;3:84. Epub 2018 Oct 17.

Great Ormond Street Hospital for Children NHS Foundation Trust, London, WC1N 3JH, UK.

Mutations of the common cytokine receptor gamma chain (γc) cause Severe Combined Immunodeficiency characterized by absent T and NK cell development. Although stem cell therapy restores these lineages, residual immune defects are observed that may result from selective persistence of γc-deficiency in myeloid lineages. However, little is known about the contribution of myeloid-expressed γc to protective immune responses. Read More

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October 2018

Pattern recognition receptor polymorphisms in early periodontitis.

J Periodontol 2018 Dec 5. Epub 2018 Dec 5.

Section of Periodontology, Department of Dentistry and Oral Health, Faculty of Health Sciences, Aarhus University, Denmark.

Background: Even though bacteria trigger inflammation, most of the tissue destruction in periodontitis is due to the host inflammatory response. In addition to immunological events that drive development of early periodontitis, numerous environmental factors like genetics and smoking play a role. We investigated whether the carriage of selected single nucleotide polymorphisms (SNP) of toll-like receptors (TLR), NOD-like receptors (NLR) and RIG-I-like receptors (RLR) was associated with the diagnosis of early periodontitis in a case-control study. Read More

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December 2018
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Welfare indicators for laying Japanese quails caged at different densities.

An Acad Bras Cienc 2018 Oct-Dec;90(4):3791-3797

Granja Kakimoto, Estrada Seção Cascata, Km 7, 17690-000 Bastos, SP, Brazil.

In the way to reduce costs in the poultry production, high densities of birds are adopted in the production systems. Such high densities can lead to an inappropriate environment, compromising the welfare and decreasing the animal performance. In this work we aimed to evaluate the effects of different densities on the productive yield, egg quality and immunological aspects of Japanese quails. Read More

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March 2018
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Differential expression of DLG1 as a common trait in different human diseases: an encouraging issue in molecular pathology.

Biol Chem 2018 Dec 1. Epub 2018 Dec 1.

Instituto de Biología Molecular y Celular de Rosario-CONICET, Facultad de Ciencias Bioquímicas y Farmacéuticas, Universidad Nacional de Rosario, Suipacha, Rosario, Argentina.

Human Disc large (DLG1) is a scaffolding protein that through the interaction with diverse cell partners participates in the control of key cellular processes such as polarity, proliferation and migration. Experimental data have mainly identified DLG1 as a tumor suppressor. An outstanding point for DLG1 protein is that altered DLG1 expression and DLG1 gene mutations were observed in different pathologies, including cancer and neurological and immunological disorders. Read More

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December 2018
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Bronchiectasis and asthma: a dangerous liaison?

Curr Opin Allergy Clin Immunol 2018 Dec 3. Epub 2018 Dec 3.

Respiratory Medicine Unit, A.O.U. 'Policlinico-Vittorio Emanuele', Department of Clinical and Experimental Medicine, University of Catania, Catania, Italy.

Purpose Of Review: To explore the latest insight of the literature on the asthma/bronchiectasis phenotype providing an updated overview about epidemiological, clinical and biological evidence linking these two conditions.

Recent Findings: An increasing body of literature has shown that the association of asthma and bronchiectasis is a frequent phenomenon leading to a more severe disease with frequent exacerbations. The mechanisms by which the two diseases are linked are still not well established but they share several clinical and immunological features and many comorbidities. Read More

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December 2018