1,715 results match your criteria Immunological Investigations [Journal]


A Meta-Analysis of Cardiovascular Events in Systemic Lupus Erythematosus.

Immunol Invest 2019 Apr 8:1-16. Epub 2019 Apr 8.

a Department of Epidemiology and Health Statistics , School of Public Health, Anhui Medical University , Hefei , Anhui , China.

Objective: To identify accurate occurrence and risk of cardiovascular (CV) events (stroke and myocardial infarction [MI]) in patients with systemic lupus erythematosus (SLE).

Methods: Systemic literature search in PubMed and additional manual search were performed to obtain interested studies until March 31, 2018. The pooled incidences and risk of stroke and MI were calculated. Read More

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http://dx.doi.org/10.1080/08820139.2019.1567534DOI Listing
April 2019
3 Reads

Analysis of Inflammatory Gene Expression Profile of Peripheral Blood Leukocytes in Type 2 Diabetes.

Immunol Invest 2019 Apr 8:1-14. Epub 2019 Apr 8.

c National Institute of Diabetes and Endocrinology , Dow University Health Sciences , Karachi , Pakistan.

The pathophysiology of type 2 diabetes (T2DM) is associated with perturbation of innate immune response. Several studies indicated alteration of pro-inflammatory and anti-inflammatory cytokines, chemokines and other mediators of innate immune response in T2DM. This study was designed to perform quantitative PCR-based expression profiling of genes involved in inflammation (i. Read More

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http://dx.doi.org/10.1080/08820139.2019.1586917DOI Listing

The Effects of Silymarin and Cyclosporine A on the Proliferation and Cytokine Production of Regulatory T Cells.

Immunol Invest 2019 Apr 4:1-16. Epub 2019 Apr 4.

c Department of Immunology, School of Medicine , Isfahan University of Medical Sciences , Isfahan , Iran.

Background: Immunosuppressive agents are necessary to enhance allograft tolerance after transplantation and the treatment of autoimmune disorders. Regulatory T cells (Tregs) play a pivotal role in improving allograft tolerance and determining the fate of transplanted organs. Therefore, the aim of this study was to investigate the immunomodulatory effects of cyclosporine A (CsA) and silymarin on the proliferation and cytokine production of Tregs. Read More

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https://www.tandfonline.com/doi/full/10.1080/08820139.2019.1
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http://dx.doi.org/10.1080/08820139.2019.1571506DOI Listing
April 2019
2 Reads

The Impact of HLA-G 3'UTR Polymorphisms in Breast Cancer in a Tunisian Population.

Immunol Invest 2019 Apr 4:1-12. Epub 2019 Apr 4.

d INSERM, U955, Translational Psychiatry , Paris-East University , Creteil , France.

Human leukocyte antigens G and E (HLA-G and HLA-E) are nonclassical major histocompatibility complex (MHC) class I molecules. These molecules play an important role in immune surveillance by inhibiting natural killer and cytotoxic T cells responsible for immune escape. The expression of HLA-G and HLA-E has been associated with several diseases including tumor. Read More

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http://dx.doi.org/10.1080/08820139.2019.1569043DOI Listing
April 2019
2 Reads
1.903 Impact Factor

The Immuno-Enhancement Effects of Tubiechong (Eupolyphaga sinensis) Lyophilized Powder in Cyclophosphamide-Induced Immunosuppressed Mice.

Immunol Invest 2019 Mar 27:1-16. Epub 2019 Mar 27.

a College of Pharmaceutical science , Zhejiang Chinese Medical University , Hangzhou , China.

Tubiechong (Eupolyphaga sinensis) is an important material used in traditional Chinese medicine (TCM). However, the immunoregulation effects of E. sinensis Lyophilized Powder (ESL) are unclear. Read More

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http://dx.doi.org/10.1080/08820139.2019.1588291DOI Listing
March 2019
1 Read

The Effect of IL-26 on TNF-α-Induced CXCL8 Responses by Colonic Epithelial Cell Lines.

Immunol Invest 2019 Mar 27:1-13. Epub 2019 Mar 27.

a Department of Biological Sciences , Binghamton University (SUNY) , Binghamton , New York USA.

Th17 cells of the intestine and colon can produce several important cytokines during mucosal inflammation. However, few studies have focused on the role of IL-26 in intestinal inflammations. Colonic epithelial cells express receptors for IL-26, and this cytokine has been shown to induce the HT-29 colonic epithelial cell line to produce the chemokine CXCL8. Read More

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http://dx.doi.org/10.1080/08820139.2019.1594247DOI Listing

Autophagy-Related 5 Gene rs510432 Polymorphism Is Associated with Hepatocellular Carcinoma in Patients with Chronic Hepatitis B Virus Infection.

Immunol Invest 2019 Mar 25:1-14. Epub 2019 Mar 25.

a Department of Infectious Diseases , First Affiliated Hospital of Xi'an Jiaotong University , Xi'an , Shaanxi , People's Republic of China.

Background: Despite the identification of autophagy-related protein 5 (ATG5) as a molecule involved in the activated autophagy machinery during hepatitis B virus (HBV) infection and hepatocarcinogenesis, the consequences of ATG5 mutation carriage for patients with chronic HBV infection remain unclear. This study examined the association of ATG5 polymorphisms with HBV-related diseases including hepatocellular carcinoma (HCC).

Patients And Methods: Two functionally relevant polymorphisms ATG5 rs573775 and rs510432 were genotyped by ligase detection reaction-polymerase chain reaction in 403 patients with chronic HBV infection (171 chronic hepatitis, 119 cirrhosis and 113 HCC) and 196 healthy controls. Read More

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http://dx.doi.org/10.1080/08820139.2019.1567532DOI Listing
March 2019
1 Read

Exogenous Melatonin Up-Regulates Expression of CD62L by Lymphocytes in Aged Mice under Inflammatory and Non-Inflammatory Conditions.

Immunol Invest 2019 Mar 19:1-12. Epub 2019 Mar 19.

d Department of New Technologies , Saint-Petersburg Pasteur Institute , Saint-Petersburg , Russia.

It is well documented that age-related impaired functioning of immunocompetent cells is associated with an increase in the rates of chronic inflammatory diseases. Recently, an ability of melatonin to modulate inflammatory processes by regulating leucocyte recruitment has been demonstrated. However, to date, no studies have attempted to determine the impact of melatonin on the expression of CD62L by lymphocytes. Read More

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http://dx.doi.org/10.1080/08820139.2019.1586918DOI Listing
March 2019
2 Reads
1.903 Impact Factor

The First Purine Nucleoside Phosphorylase Deficiency Patient Resembling IgA Deficiency and a Review of the Literature.

Immunol Invest 2019 Mar 19:1-21. Epub 2019 Mar 19.

a Research Center for Immunodeficiencies, Pediatrics Center of Excellence, Children's Medical Center , Tehran, and the University of Medical Science , Tehran , Iran.

Purine nucleoside phosphorylase (PNP) deficiency is a rare autosomal recessive primary immunodeficiency disorder characterized by decreased numbers of T-cells, variable B-cell abnormalities, decreased amount of serum uric acid and PNP enzyme activity. The affected patients usually present with recurrent infections, neurological dysfunction and autoimmune phenomena. In this study, whole-exome sequencing was used to detect mutation in the case suspected of having primary immunodeficiency. Read More

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https://www.tandfonline.com/doi/full/10.1080/08820139.2019.1
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http://dx.doi.org/10.1080/08820139.2019.1570249DOI Listing
March 2019
3 Reads
1.903 Impact Factor

ECTV Abolishes the Ability of GM-BM Cells to Stimulate Allogeneic CD4 T Cells in a Mouse Strain-Independent Manner.

Immunol Invest 2019 Mar 19:1-18. Epub 2019 Mar 19.

a Department of Preclinical Sciences, Faculty of Veterinary Medicine , Warsaw University of Life Sciences , Warsaw , Poland.

Ectromelia virus (ECTV) is the etiological agent of mousepox, an acute and systemic disease with high mortality rates in susceptible strains of mice. Resistance and susceptibility to mousepox are triggered by the dichotomous T-helper (Th) immune response generated in infected animals, with strong protective Th1 or nonprotective Th2 profile, respectively. Th1/Th2 balance is influenced by dendritic cells (DCs), which were shown to differ in their ability to polarize naïve CD4 T cells in different mouse strains. Read More

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http://dx.doi.org/10.1080/08820139.2019.1569676DOI Listing

MALAT1 Genomic Variants and Risk of Multiple Sclerosis.

Immunol Invest 2019 Mar 1:1-6. Epub 2019 Mar 1.

d Urogenital Stem Cell Research Center , Shahid Beheshti University of Medical Sciences , Tehran , Iran.

Metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) is a long noncoding RNA (lncRNA) with a possible role in the regulation of immune responses. A previous study has demonstrated down-regulation of this lncRNA in multiple sclerosis (MS) patients. In the current study, we genotyped two MALAT1 single nucleotide polymorphisms (SNPs) in 428 Iranian MS patients and 505 healthy subjects. Read More

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http://dx.doi.org/10.1080/08820139.2019.1576728DOI Listing
March 2019
1 Read

Relative Expression of OX40, OX40L mRNA, and OX40L Serum Levels in Women with Recurrent Spontaneous Abortion.

Immunol Invest 2019 Feb 22:1-10. Epub 2019 Feb 22.

b Abortion Research Centre, Reproductive Sciences Institute , Shahid Sadoughi University of Medical Sciences , Yazd , Iran.

This study determined the roles of OX40 and OX40L in women with recurrent spontaneous abortion (RSA). We compared the expression of OX40 and OX40L genes in peripheral blood mRNA levels and serum levels of OX40L in women with a history of RSA to the control group. In this case-control study, 40 women with a history of RSA (case group), and 40 others with no history of abortion (control group) were investigated. Read More

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http://dx.doi.org/10.1080/08820139.2019.1567530DOI Listing
February 2019
1 Read
1.903 Impact Factor

Cloning and Analysis of the Multiple Transcriptomes of Serine Protease Homologs in Crayfish (Procambarus clarkii).

Authors:
Yong Zeng

Immunol Invest 2019 Feb 22:1-9. Epub 2019 Feb 22.

a College of Life Sciences , Yantai University , Yantai , Shandong , PR China.

Five different serine protease homologs (SPH) transcripts presumably or possibly resulting from alternative splicing were cloned from the hemocytes of crayfish (Procambarus clarkii) in this paper. Although different deletions of cDNA of SPH-2 and SPH-4 were found in the 5' untranslated regions, they shared the same open reading frame and encoded a 424 amino acids protein with a calculated molecular weight of 45.84 kDa compared with SPH-5. Read More

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http://dx.doi.org/10.1080/08820139.2018.1509870DOI Listing
February 2019

Maternal Serum sEndoglin and Cell-Free Fetal DNA as Probable Markers of Preeclampsia: A Study in Single Center, Egypt.

Immunol Invest 2019 Feb 22:1-10. Epub 2019 Feb 22.

b Obstetrics and Gynecology Department, Faculty of Medicine , Mansoura University , Mansoura , Egypt.

Background: This study was conducted to compare the levels of maternal serum soluble endoglin (sEng) and cell-free fetal DNA (cffDNA) in pregnant females with PE to normotensive pregnant ones, together with relating these levels to preeclampsia (PE) severity and onset. Method of the study: It was a comparative study in Mansoura University Hospital, Egypt, to detect the levels of serum sEng by ELISA besides the levels of cffDNA by quantitative real-time polymerase chain reaction in 80 pregnant females suffering from PE in addition to 80 normotensive pregnant ones that were included as control.

Results: Levels of serum sEng and cffDNA were higher in PE cases than control (p < 0. Read More

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http://dx.doi.org/10.1080/08820139.2019.1578790DOI Listing
February 2019
2 Reads

Prognostic Values of CD38CD101PD1CD8 T Cells in Pancreatic Cancer.

Immunol Invest 2019 Jan 28:1-14. Epub 2019 Jan 28.

a Department of Pathophysiology , Third Military Medical University , Chongqing , PR China.

Programmed death-1 (PD-1), a key immune checkpoint molecule, has been developed as an oncotherapy target for various carcinomas. However, treatment with anti-PD-1 elicited only a minimal effect in pancreatic ductal adenocarcinoma (PDAC). Subsequent studies revealed the existence of a subset of PD-1 T cells coexpressing CD38 and CD101, representing a fixed dysfunctional subpopulation that are not able to be rescued by anti-PD-1 immunotherapy. Read More

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http://dx.doi.org/10.1080/08820139.2019.1566356DOI Listing
January 2019
1 Read
1.903 Impact Factor

Neutrophil Functions in Immunodeficiency Due to DOCK8 Deficiency.

Immunol Invest 2019 Jan 28:1-9. Epub 2019 Jan 28.

a Pediatric Immunology Clinic.

Neutrophil chemotactic defects have been reported previously in patients with hyper-IgE syndrome. Bi-allelic mutations in dedicator of cytokinesis 8 (DOCK8) gene usually cause an autosomal recessive hyper-IgE syndrome phenotype. Data are lacking about expression of DOCK8 protein in neutrophils or the possible role of DOCK8 in neutrophil function. Read More

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https://www.tandfonline.com/doi/full/10.1080/08820139.2019.1
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http://dx.doi.org/10.1080/08820139.2019.1567533DOI Listing
January 2019
13 Reads

Serum Levels of OPG, RANKL, and RANKL/OPG Ratio in Patients with Ankylosing Spondylitis: A Systematic Review and Meta-analysis.

Immunol Invest 2019 Jan 28:1-15. Epub 2019 Jan 28.

a Department of Epidemiology and Biostatistics, School of Public Health , Anhui Medical University , Hefei , Anhui , China.

Objectives: To investigate the role of osteoprotegerin (OPG), receptor activator of nuclear factor-kB ligand (RANKL), and RANKL/OPG ratio in the pathogenesis of ankylosing spondylitis (AS).

Methods: Studies that compared serum levels of OPG, RANKL, and RANKL/OPG ratio between AS patients and healthy controls were gathered. Pooled standardized mean differences (SMDs) with 95% confidence intervals (CIs) were calculated by the random-effects model. Read More

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http://dx.doi.org/10.1080/08820139.2019.1567531DOI Listing
January 2019
2 Reads
1.903 Impact Factor

LPS-induced Apoptosis is Partially Mediated by Hydrogen Sulphide in RAW 264.7 Murine Macrophages.

Immunol Invest 2019 Jan 28:1-15. Epub 2019 Jan 28.

a School BioSciences and Technology , Vellore Institute of Technology, VIT University , Vellore , India.

Lipopolysaccharide (LPS) induces apoptosis in murine macrophages through the autocrine secretion of tumor necrosis factor (TNF)-α and nitric oxide (NO). LPS-induced inflammation in murine macrophages is associated with hydrogen sulfide (HS) production. In this present study, we reported the novel role of HS in LPS-induced apoptosis and its underlying molecular mechanism specifically at late phases in murine macrophage cells. Read More

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https://www.tandfonline.com/doi/full/10.1080/08820139.2019.1
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http://dx.doi.org/10.1080/08820139.2019.1566355DOI Listing
January 2019
2 Reads

TNF May Negatively Regulate Phagocytosis of Devil Facial Tumour Disease Cells by Activated Macrophages.

Immunol Invest 2019 Jan 19:1-13. Epub 2019 Jan 19.

a Menzies Institute for Medical Research, College of Health and Medicine , University of Tasmania , Hobart , Tasmania , Australia.

Introduction: Macrophage phagocytosis of pathogens and tumour cells is an important early event in protection against infectious disease and cancer. As tumour necrosis factor α (TNF) is an important cytokine in macrophage activation, we investigated the involvement of TNF in macrophage phagocytosis of tumour cells.

Methods: We used Devil Facial Tumour Disease (DFTD) cancer cells as the target tumour cells. Read More

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http://dx.doi.org/10.1080/08820139.2018.1515222DOI Listing
January 2019
2 Reads

Effects of Soluble Tumor Necrosis Factor (TNF) on Antibody-Dependent Cellular Cytotoxicity of Therapeutic anti-TNF-α Antibody.

Immunol Invest 2018 Dec 20:1-10. Epub 2018 Dec 20.

a Chemicals Assessment and Research Center , Chemicals Evaluation and Research Institute , Saitama , Japan.

Anti-TNF antibodies are major therapeutics for rheumatoid arthritis and have been approved for marketing in many countries. Antibody-dependent cellular cytotoxicity (ADCC) is considered to be a potential mechanism of action of anti-TNF antibodies, since some anti-TNF antibodies have been confirmed to induce cytotoxic effects on TNF-producing cells via ADCC and complement-dependent cytotoxicity (CDC) in in vitro experiments. In this study, we established a new stable effector cell line expressing human FcγRIIIa, CD16:KHYG-1, and compared the performance of this cell line with that of peripheral blood mononuclear cells (PBMCs) in ADCC assays against CHO-derived target cells expressing protease-sensitive pro-TNF. Read More

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http://dx.doi.org/10.1080/08820139.2018.1549067DOI Listing
December 2018
5 Reads

Decreased Gene Expression of Epstein-Barr Virus-Induced Gene 3 (EBI-3) may Contribute to the Pathogenesis of Rheumatoid Arthritis.

Immunol Invest 2018 Dec 4:1-11. Epub 2018 Dec 4.

a Department of Immunology , Kermanshah University of Medical Sciences , Kermanshah , Iran.

Background: Interleukin-35 (IL-35) is a member of the IL-12 family of heterodimeric cytokines produced by regulatory T (Treg) cells. This immunosuppressive cytokine can prevent exaggerated inflammatory responses like those responsible for the development of rheumatoid arthritis (RA). This study aims to determine the correlation between the gene expression of Epstein-Barr virus-induced gene 3 (EBI-3) and IL-12A (p35) subunits of IL-35 in peripheral blood leukocytes with immunological and clinical parameters in RA patients. Read More

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http://dx.doi.org/10.1080/08820139.2018.1549066DOI Listing
December 2018
4 Reads
2.588 Impact Factor

Immune Correlates of Protection Induced by Virus-Like Particles Containing 2009 H1N1 Pandemic Influenza HA, NA or M1 Proteins.

Immunol Invest 2018 Nov 15:1-12. Epub 2018 Nov 15.

a Department of Medical Zoology , Kyung Hee University School of Medicine , Seoul , Korea.

Influenza virus-like particle (VLPs) vaccines are a promising alternative to conventional egg-based vaccines. Evaluation of vaccine efficacy induced by HA-M1 VLPs, NA-M1 VLPs or M1 VLPs against virus challenge infection would provide important insight into vaccine design strategy. In this study, we generated VLPs containing hemagglutinin (HA), neuraminidase (NA) or M1 proteins derived from the A/California/04/09. Read More

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http://dx.doi.org/10.1080/08820139.2018.1544640DOI Listing
November 2018
14 Reads

Body Mass Index and Mortality in Elderly Subjects from the Moli-Sani Study: A Possible Mediation by Low-Grade Inflammation?

Immunol Invest 2018 Nov 13;47(8):774-789. Epub 2018 Nov 13.

b Department of Epidemiology and Prevention , IRCCS Neuromed , Pozzilli (IS) , Italy.

The association between obesity and mortality in the elderly remains controversial. To test the association between BMI and mortality, with the hypothesis of a mediation by low-grade inflammation (LGI), a prospective study design (median follow-up 7.8 years) was used on a sample of 4,970 elderly subjects (age ≥ 65 years) from the Moli-sani Study cohort. Read More

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http://dx.doi.org/10.1080/08820139.2018.1538237DOI Listing
November 2018
4 Reads

Characterization of Natural Killer Cells in HIV Patients Beginning Therapy with a High Burden of Cytomegalovirus.

Immunol Invest 2018 Nov 13:1-10. Epub 2018 Nov 13.

a Faculty of Medicine, Virology and Cancer Pathobiology Research Center , Universitas Indonesia , Jakarta , Indonesia.

Background: Active infections with cytomegalovirus (CMV) increase NK cell expression of the inhibitory receptor LIR-1 and the activating receptor NKG2C in transplant recipients. However, the effects of CMV on NK cells are different in HIV patients stable on antiretroviral therapy (ART) and have not been analyzed in young HIV patients beginning ART.

Methodology: We followed a cohort of 78 Indonesian HIV patients beginning ART. Read More

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https://www.tandfonline.com/doi/full/10.1080/08820139.2018.1
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http://dx.doi.org/10.1080/08820139.2018.1538236DOI Listing
November 2018
18 Reads

PD-1 Haplotype Combinations and Susceptibility of Patients to Squamous Cell Carcinomas of Head and Neck.

Immunol Invest 2019 Jan 30;48(1):1-10. Epub 2018 Oct 30.

a Department of Immunology , School of Medicine, Shiraz University of Medical Sciences , Shiraz , Iran.

Introduction: Head and neck squamous cell carcinomas (HNSCCs) are the most common cancers of head and neck and the sixth most common malignancy worldwide. Programmed cell death 1 (PD-1) is an immune inhibitory molecule which through interaction with its ligands recruits protein phosphatase resulting in immune response inhibition. Expression of PD-1 ligands on tumor cells is considered as one of the crucial immune evasion mechanisms. Read More

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https://www.tandfonline.com/doi/full/10.1080/08820139.2018.1
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http://dx.doi.org/10.1080/08820139.2018.1538235DOI Listing
January 2019
3 Reads

Comparative Analysis of Bone Marrow-derived Mast Cell Differentiation in C57BL/6 and BALB/c Mice.

Immunol Invest 2019 Apr 18;48(3):303-320. Epub 2018 Oct 18.

a Host Defense for Animals , Nippon Veterinary and Life Science University , Musashino-shi, Tokyo , Japan.

Allergic diseases have increased in the last three decades. Mast cells play a critical role in allergic diseases along with allergen-specific immunoglobulin E (IgE). Following mast cell degranulation elicited by ligation of the IgE-FcεRI receptor complex with allergen, allergic reactions are followed by various symptoms such as vascular hyperpermeability, mucous secretion, itching, sneezing, wheezing, rashes, fever, and anaphylactic shock. Read More

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https://www.tandfonline.com/doi/full/10.1080/08820139.2018.1
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http://dx.doi.org/10.1080/08820139.2018.1523924DOI Listing
April 2019
12 Reads

Thyroglobulin Antibodies are Associated with Symptom Burden in Patients with Hashimoto's Thyroiditis: A Cross-Sectional Study.

Immunol Invest 2019 Feb 17;48(2):198-209. Epub 2018 Oct 17.

b Department of Medical Biology , University of Split, School of Medicine , Split , Croatia.

Background: Hashimoto's thyroiditis (HT) is the most common form of autoimmune thyroid disorders characterized by lower production of thyroid hormones and positivity to autoantibodies to thyroglobulin (TgAb) and/or thyroid peroxidase (TPOAb). We performed a comprehensive phenotypic characterization of patients with HT, with specific focus on thyroid autoimmunity, to get better understanding of disease manifestation.

Methods: We collected information on thyroid-specific phenotypes (TSH, T3, T4, fT4, TgAb, TPOAb, thyroid volume) and other clinical phenotypes (age, body surface area, number of hypothyroidism symptoms, blood pressure) from 290 patients with HT without levothyroxine (LT4) therapy with the aim to test for correlations between thyroid-specific and clinical phenotypes. Read More

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http://dx.doi.org/10.1080/08820139.2018.1529040DOI Listing
February 2019
5 Reads

Association of KIR Genotypes and Haplotypes in HBeAg-positive Chronic Hepatitis B Patients Treated with Entecavir.

Immunol Invest 2018 Oct 16:1-12. Epub 2018 Oct 16.

e Department of Biochemistry and Molecular Biology , Medical college of Shandong University , Jinan , Shandong Province , P. R. China.

Background: A large proportion of patients with chronic hepatitis B (CHB) in China do not respond to entecavir (ETV) treatment. It remains unclear whether the Killer immunoglobulin-like receptor (KIR) genotypes and haplotypes were associated with the advantage of seroconversion in phepatitis B e-Antigen (HBeAg) positive CHB patients treated with ETV.

Methods: Polymerase chain reaction with sequence-specific primers (PCR-SSP) was used to analyze KIR genes in a Chinese Han population of 198 ETV-treated HBeAg-positive CHB patients and 200 healthy controls. Read More

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https://www.tandfonline.com/doi/full/10.1080/08820139.2018.1
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http://dx.doi.org/10.1080/08820139.2018.1529791DOI Listing
October 2018
6 Reads

Evaluation and characteristics of immunological adjuvant activity of purified fraction of Albizia julibrissin saponins.

Immunol Invest 2019 Apr 16;48(3):283-302. Epub 2018 Oct 16.

a College of Animal Sciences , Zhejiang University , Hangzhou , Zhejiang China.

Purpose: The purified fraction of Albizia julibrissin saponins (AJSAF) was evaluated and characterized for the adjuvant activity on porcine reproductive and respiratory syndrome virus (PRRSV) vaccine.

Methods: The effects of AJSAF on serum PRRSV N protein-specific antibody titers, splenocyte proliferation, natural killer (NK) cell activity, mRNA expression of cytokines and transcription factors, secretion of cytokines, T cells response in splenocytes, as well as delayed type hypersensitivity (DTH) in the mice immunized PRRSV vaccine were determined by ELISA, MTT assay, flow cytometry and quantitative real-time PCR (qRT-PCR).

Results: AJSAF not only significantly enhanced the serum PRRSV N protein-specific IgG, IgG1, IgG2a and IgG2b antibody titers in the mice immunized with PRRSV CH-1R modified live vaccine (CH-1R MLV), inactivated vaccine (CH-1R IAV), and highly pathogenic JXA1-R modified live vaccine (JXA1-R MLV), but promoted the concanavalin A (Con A)-, lipopolysaccharide (LPS)- and PRRSV N protein-stimulated splenocyte proliferation, the activities of NK cells and delayed type hypersensitivity (DTH) in the mice immunized CH-1R MLV. Read More

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https://www.tandfonline.com/doi/full/10.1080/08820139.2018.1
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http://dx.doi.org/10.1080/08820139.2018.1523923DOI Listing
April 2019
5 Reads

Regulatory T Cells and Their Association with Serum Markers and Symptoms in Systemic Lupus Erythematosus and Rheumatoid Arthritis.

Immunol Invest 2019 Jan 16;48(1):64-78. Epub 2018 Oct 16.

c Department of Biochemistry, Institute of Medical Sciences , Banaras Hindu University , Varanasi , India.

Purpose: Impairment in number and functions of regulatory T cells (Treg) has been found to be associated with many autoimmune diseases including systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA). This study was conducted to identify and compare Treg by flow cytometry using two different staining approaches.

Methods: Treg were identified by using CD4+CD25+high and CD4+CD25+CD127dim staining approaches in SLE and RA patients and healthy controls. Read More

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http://dx.doi.org/10.1080/08820139.2018.1527852DOI Listing
January 2019
2 Reads
1.903 Impact Factor

Biological Markers of Oxidative Stress in Cardiovascular Diseases: After so Many Studies, What do We Know?

Immunol Invest 2018 Oct 15:1-21. Epub 2018 Oct 15.

c Department of Pathology , University of Louisville , Louisville , KY USA.

Numerous conditions, including cancer, diabetes, aging, and atherosclerosis, are thought to be associated with oxidative stress. Oxidative stress is defined as a persistent imbalance between oxidation and antioxidation, resulting in the damage of cellular macromolecules and is often considered to be involved in wide variety of human diseases. However, the current literature is very heterogeneous making it rather difficult to draw general conclusions. Read More

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http://dx.doi.org/10.1080/08820139.2018.1523925DOI Listing
October 2018
1 Read

Association between Toll-Like Receptor 3 (TLR3) rs3775290, TLR7 rs179008, TLR9 rs352140 and Chronic HCV.

Immunol Invest 2019 Apr 15;48(3):321-332. Epub 2018 Oct 15.

a Clinical Immunology Unit, Clinical Pathology Department, Mansoura Faculty of Medicine , Mansoura University , Mansoura , Egypt.

Background: Inconsistent results were reported on the association of TLRs polymorphisms with the risk of HCV infection and HCV-related diseases.

Objective: to assess the relation between TLR3 rs3775290, TLR7 rs17900 and TLR9 rs352140 SNPs and chronic HCV in the Egyptian cohort and to study their relation to interferon response.

Methods: TLR3 rs3775290, TLR7 rs179008 and TLR9 rs352140 gene polymorphisms were typed by RFLP for 100 patients with chronic HCV and 25 with HCC in addition to 100 healthy controls. Read More

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http://dx.doi.org/10.1080/08820139.2018.1527851DOI Listing
April 2019
1 Read

Antigen-Presenting Cell Characteristics of Human γδ T Lymphocytes in Chronic Myeloid Leukemia.

Immunol Invest 2019 Jan 15;48(1):11-26. Epub 2018 Oct 15.

a Center for Research and Innovation, Faculty of Medical Technology , Mahidol University , Bangkok , Thailand.

Human γδ T lymphocytes play a role in the immune system defense against cancer. Their broad anti-cancer activity against different types of cancers makes them outstanding candidates for cancer immunotherapy. An issue of recent interest is whether their antigen presentation features are similar to mature dendritic cells. Read More

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https://www.tandfonline.com/doi/full/10.1080/08820139.2018.1
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http://dx.doi.org/10.1080/08820139.2018.1529039DOI Listing
January 2019
5 Reads

Adipokines in Multiple Sclerosis Patients with and without Optic Neuritis as the First Clinical Presentation.

Immunol Invest 2019 Feb 15;48(2):190-197. Epub 2018 Oct 15.

c Department of Neuroscience Institute for Experimental Medicine , Istanbul University , Istanbul , Turkey.

Background: Adipocytokines have been implied to be involved in multiple sclerosis (MS) pathogenesis. MS patients whose first clinical episode is optic neuritis (ON) have been reported to display a milder disease course. In this study, we aimed to show whether this milder disease course is related to reduced adipokine production. Read More

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http://dx.doi.org/10.1080/08820139.2018.1528270DOI Listing
February 2019
3 Reads

The Relationship of COX-2 Gene Polymorphisms and Susceptibility to Kawasaki Disease in Chinese Population.

Immunol Invest 2019 Feb 15;48(2):181-189. Epub 2018 Oct 15.

a Department of Pediatrics , The Third Xiangya Hospital of Central South University , Changsha , Hunan China.

Background: Kawasaki disease (KD) is an acute systemic vasculitis that predominantly affects children, and it can result in coronary artery lesions. Cyclooxygenase-2 (COX-2) is involved in the conversion of arachidonic acid to prostaglandin H2, an important precursor of several prostaglandins. The aim of this study was to examine the association between COX-2 gene polymorphisms and susceptibility to KD. Read More

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http://dx.doi.org/10.1080/08820139.2018.1529790DOI Listing
February 2019
2 Reads

Genetic Relationship Between IL-6 rs1800796 Polymorphism and Susceptibility to Periodontitis.

Immunol Invest 2019 Apr 9;48(3):268-282. Epub 2018 Oct 9.

a Dental Department , Tianjin First Center Hospital , Tianjin , People's Republic of China.

Background: There are accumulating reports for the potential role of Interleukin-6 (IL-6) rs1800796 polymorphism in the risk of periodontitis. However, distinct conclusions are observed. In this study, we have an interest in comprehensively analyzing the genetic relationship between IL-6 rs1800796 and the susceptibility to periodontitis. Read More

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https://www.tandfonline.com/doi/full/10.1080/08820139.2018.1
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http://dx.doi.org/10.1080/08820139.2018.1517365DOI Listing
April 2019
3 Reads

Analysis of the Association of Polymorphisms rs5743708 in TLR2 and rs4986790 in TLR4 with Atopic Dermatitis Risk.

Immunol Invest 2019 Feb 1;48(2):169-180. Epub 2018 Oct 1.

a Department of Dermatology , Shengli Oilfield Central Hospital , Shandong , China.

Background: We carried out a meta-analysis to assess whether Toll-like receptor 2 (TLR2) rs5743708 and Toll-like receptor 4 (TLR4) rs4986790 polymorphisms are associated with the risk of atopic dermatitis.

Methods: A systematic search of PubMed, Embase, and Web of Science was performed to identify eligible case-control studies on the association of rs5743708 and rs4986790 with the risk of atopic dermatitis. Statistical analyses of the odds ratio (OR), 95% confidence interval (CI), and p value were performed using STATA software. Read More

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http://dx.doi.org/10.1080/08820139.2018.1508228DOI Listing
February 2019
2 Reads
1.903 Impact Factor

HLA Class I in Egyptian patients with Behçet's disease: new association with susceptibility, protection, presentation and severity of manifestations.

Immunol Invest 2019 Feb 27;48(2):121-129. Epub 2018 Sep 27.

a Rheumatology and Rehabilitation Department , Cairo University , Cairo , Egypt.

Introduction: Behçet's disease is an autoimmune disease with diverse clinical manifestations with vasculitis being the hallmark of the disease. The aim of this work is to study the genetic association between human leukocyte antigen (HLA) class-I molecules of Egyptians with Behçet's disease and the disease susceptibility and clinical patterns.

Methods: Fifty-seven patients diagnosed with Behçet's disease according to the 1990 International Study Group (ISG) criteria for Behçet's disease coming from Egyptian origin up to the third grandfather were included in the study. Read More

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http://dx.doi.org/10.1080/08820139.2018.1517364DOI Listing
February 2019
3 Reads
1.903 Impact Factor

miR-350-3p Contributes to Age-Associated Impairment of IL-6 Production by Macrophages.

Immunol Invest 2018 Sep 27:1-11. Epub 2018 Sep 27.

a Department of Cardiology , The First Affiliated Hospital, Cardiovascular Institute, Harbin Medical University , Harbin , P.R. China.

Aging-associated dysfunction of the immune system contributes to the increase in pathophysiological processes that occur with age. Numerous studies have shown that microRNAs regulate immune responses, although their role in age-related macrophage dysfunction remains elusive. Here, we found that miR-350-3p is expressed at lower levels in peritoneal macrophages from aged mice compared with young mice, and that lipopolysaccharide (LPS) stimulation downregulates miR-350-3p expression to a greater extent in young macrophages compared with aged macrophages. Read More

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http://dx.doi.org/10.1080/08820139.2018.1508227DOI Listing
September 2018
2 Reads

Direct Engagement of TLR9 Ligand with T Helper Cells Leads to Cell Proliferation & Up-regulation of Cytokines.

Immunol Invest 2019 Jan 21;48(1):79-95. Epub 2018 Sep 21.

a Advanced Eye Center , Post graduate Institute of Medical Education and Research , Chandigarh , India.

Purpose: Toll like receptor (TLR) engagement is primarily a function of the innate immune cells. The purpose of the study was to assess direct uptake of ODN 2216 in T helper cells and effects on cell proliferation and cytokine expression.

Methods: We isolated CD4+ CD25- T helper cells by magnetic sorting and studied the uptake of ODN 2216 using flow cytometry and confocal microscopy. Read More

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http://dx.doi.org/10.1080/08820139.2018.1515223DOI Listing
January 2019
7 Reads
1.903 Impact Factor

Enhanced Anti-Leukemic Effects through Induction of Immunomodulating Microenvironment by Blocking CXCR4 and PD-L1 in an AML Mouse Model.

Immunol Invest 2019 Jan 11;48(1):96-105. Epub 2018 Sep 11.

a Leukemia Research Institute, Seoul St. Mary's Hospital, College of Medicine , The Catholic University of Korea , Seoul , Korea.

Previously, we found that dual therapy by the CXCR4 inhibitor Plerixafor and cytosine arabinoside (Ara-C) effectively eradicated leukemia cells and concurrently activated immune cells in acute myeloid leukemia (AML). To reveal the significance of programmed death-ligand1 (PD-L1) in AML and as a strategic approach, we investigated the anti-leukemic effect of a triple combinational therapy by utilizing Plerixafor and anti-PD-L1 in combination with chemotherapy in an AML mouse model. We examined leukemic myeloid blast cells in multiple organs after the successive treatment with Ara-C, Plerixafor, and anti-PD-L1. Read More

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http://dx.doi.org/10.1080/08820139.2018.1497057DOI Listing
January 2019
14 Reads
1.903 Impact Factor

Impact of IL-27p28 (rs153109) and TNF-α (rs1800629) Genetic Polymorphisms on the Progression of HCV Infection in Egyptian Patients.

Immunol Invest 2019 Apr 11;48(3):255-267. Epub 2018 Sep 11.

a Department of Biochemistry, Pharmacy , Minia University , Minia , Egypt.

Background: Hepatitis C virus (HCV) is a universal health problem. HCV infection may proceed to liver fibrosis, cirrhosis, and eventually hepatocellular carcinoma (HCC). The latest is the third leading global cause of cancer-related mortality. Read More

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http://dx.doi.org/10.1080/08820139.2018.1510958DOI Listing
April 2019
5 Reads

Mussel adhesive Protein-conjugated Vitronectin (fp-151-VT) Induces Anti-inflammatory Activity on LPS-stimulated Macrophages and UVB-irradiated Keratinocytes.

Immunol Invest 2019 Apr 6;48(3):242-254. Epub 2018 Sep 6.

a Biotechnology & Business Center , Incheon Business Information Technopark , Incheon , Republic of Korea.

Background: Skin inflammation and dermal injuries are a major clinical problem because current therapies are limited to treating established scars, and there is a poor understanding of healing mechanisms. Mussel adhesive proteins (MAPs) have great potential in many tissue engineering and biomedical applications. It has been successfully demonstrated that the redesigned hybrid type MAP (fp-151) can be utilized as a promising adhesive biomaterial. Read More

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https://www.tandfonline.com/doi/full/10.1080/08820139.2018.1
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http://dx.doi.org/10.1080/08820139.2018.1506476DOI Listing
April 2019
27 Reads

Circulating Levels of Osteoprotegerin, Osteocalcin and Osteopontin in Patients with Rheumatoid Arthritis: A Systematic Review and Meta-Analysis.

Immunol Invest 2019 Feb 6;48(2):107-120. Epub 2018 Sep 6.

a Department of Epidemiology and Biostatistics , School of Public Health, Anhui Medical University , Hefei , Anhui , China.

Objective: Currently published data regarding the potential role of osteoprotegerin (OPG), osteocalcin (OCN) and osteopontin (OPN) for the discrimination between rheumatoid arthritis (RA) and osteoarthritis (OA) are contradictory. To derive a more precise evaluation, a meta-analysis was performed.

Methods: Published literatures comparing plasma/serum OPG, OCN and OPN levels between RA group and OA controls were searched in PubMed, Embase and the Cochrane Library. Read More

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http://dx.doi.org/10.1080/08820139.2018.1510957DOI Listing
February 2019
4 Reads

Therapeutic Use of Intrathecal Mesenchymal Stem Cells in patients with Multiple Sclerosis: A Pilot Study with Booster Injection.

Immunol Invest 2019 Feb 29;48(2):160-168. Epub 2018 Aug 29.

a MS Research Center, Neuroscience Institute , Tehran University of Medical sciences , Tehran , Iran.

Background: Mesenchymal stem cells (MSCs) are a potential therapy for various diseases. Here, the results of intrathecal injection of MSCs in multiple sclerosis (MS) patients are reported.

Materials And Methods: Four patients were enrolled in the study. Read More

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http://dx.doi.org/10.1080/08820139.2018.1504301DOI Listing
February 2019
3 Reads

Genetic Analysis of Patients with Two Different Types of Hyper IgM Syndrome.

Immunol Invest 2018 Oct 6;47(7):745-753. Epub 2018 Aug 6.

a Immunology, Asthma & Allergy Research Institute , Tehran University of Medical Sciences , Tehran , Iran.

Background: Hyper IgM Syndrome (HIGM) is a rare primary immunodeficiency in which impairment of class switching recombination (CSR) and somatic hyper-mutation (SHM) leads to recurrent infections.

Objectives: The aim of this study is to report the clinical and genetic features of six Iranian HIGM patients.

Methods: Six patients, who suspected to have HIGM based on two clinical findings, including recurrent infections and low levels of IgG and IgA and normal or elevated levels of IgM, were entered this study to undergo genetic studies. Read More

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https://www.tandfonline.com/doi/full/10.1080/08820139.2018.1
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http://dx.doi.org/10.1080/08820139.2018.1493052DOI Listing
October 2018
5 Reads

Anti-α-galactoside and Anti-β-glucoside Antibodies are Partially Occupied by Either of Two Albumin-bound O-glycoproteins and Circulate as Ligand-binding Triplets.

Immunol Invest 2019 Apr 6;48(3):222-241. Epub 2018 Aug 6.

a Department of Biochemistry , Sree Chitra Tirunal Institute for Medical Sciences and Technology , Thiruvananthapuram - India.

Two heavily O-glycosylated proteins and albumin co-purified with anti-α-galactoside (anti-Gal), the chief xenograft-rejecting antibody and anti-β-glucan (ABG) antibody isolated from human plasma by affinity chromatography on respective ligand-bearing matrices. Both antibodies and O-glycoproteins co-purified with plasma albumin eluted from albumin-specific matrix. Using components of affinity-purified antibody samples separated by electrophoresis binding of either albumin or antibody to the affinity matrix of the other or binding of O-glycoprotein to either matrix was ruled out. Read More

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http://dx.doi.org/10.1080/08820139.2018.1502299DOI Listing
April 2019
2 Reads

IL-17A and IL-23: plausible risk factors to induce age-associated inflammation in Alzheimer's disease.

Immunol Invest 2018 Aug 6:1-11. Epub 2018 Aug 6.

a Immunology of Infectious Diseases Research Center, Research Institute of Basic Medical Sciences , Rafsanjan University of Medical Sciences , Rafsanjan , Iran.

Background: Aging and its complications such as Alzheimer's disease (AD) are associated with chronic low-grade inflammation entitled age-associated inflammation. However, the main mechanisms whichinduce age-associated inflammation in aging and AD are yet to beclarified. L-23/IL-17A axis plays important roles in the induction of inflammation and consequently autoimmune disease. Read More

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http://dx.doi.org/10.1080/08820139.2018.1504300DOI Listing
August 2018
2 Reads

RNA protein kinase SNP at -226 C

Immunol Invest 2019 Apr 6;48(3):211-221. Epub 2018 Aug 6.

e Department of Microbiology and Immunology, Faculty of Medicine , Minia University , Minia , Egypt.

Background: RNA-dependant protein kinase R (PKR) is a primary mediator in the defence mechanism of interferon against viral replication and pathogenesis during Hepatitis C virus (HCV) infection. In the present study, we have examined the role of Single Nucleotide Polymorphisms (SNPs) in the promoter region of PKR and the serum level of the same protein on the outcome of HCV-infected Egyptian patients.

Patients And Methods: Genomic DNA was extracted from a total of 135 subjects, including 15 healthy controls, 40 HCV spontaneous resolvers (SRs), and 80 patients with chronic HCV infection. Read More

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http://dx.doi.org/10.1080/08820139.2018.1493496DOI Listing
April 2019
2 Reads

Comparison of the Percentage of Regulatory T cells and their p-STAT5 Expression in Allergic and Non-Allergic Common Variable Immunodeficiency Patients.

Immunol Invest 2019 Jan 31;48(1):52-63. Epub 2018 Jul 31.

a Department of Immunology, Faculty of medicine , Isfahan University of Medical Sciences , Isfahan , Iran.

Background: Common Variable Immunodeficiency (CVID) is a primary immunodeficiency characterized by an immunologic deficiency in immunoglobulin production. Regulatory T cells (Tregs) play a key role in preventing the development allergic disorders. p-STAT5 is a known factor for the function and survival of Tregs. Read More

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http://dx.doi.org/10.1080/08820139.2018.1498882DOI Listing
January 2019
7 Reads