1,701 results match your criteria Immunological Investigations [Journal]


Prognostic Values of CD38CD101PD1CD8 T Cells in Pancreatic Cancer.

Immunol Invest 2019 Jan 28:1-14. Epub 2019 Jan 28.

a Department of Pathophysiology , Third Military Medical University , Chongqing , PR China.

Programmed death-1 (PD-1), a key immune checkpoint molecule, has been developed as an oncotherapy target for various carcinomas. However, treatment with anti-PD-1 elicited only a minimal effect in pancreatic ductal adenocarcinoma (PDAC). Subsequent studies revealed the existence of a subset of PD-1 T cells coexpressing CD38 and CD101, representing a fixed dysfunctional subpopulation that are not able to be rescued by anti-PD-1 immunotherapy. Read More

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http://dx.doi.org/10.1080/08820139.2019.1566356DOI Listing
January 2019
1.903 Impact Factor

Neutrophil Functions in Immunodeficiency Due to DOCK8 Deficiency.

Immunol Invest 2019 Jan 28:1-9. Epub 2019 Jan 28.

a Pediatric Immunology Clinic.

Neutrophil chemotactic defects have been reported previously in patients with hyper-IgE syndrome. Bi-allelic mutations in dedicator of cytokinesis 8 (DOCK8) gene usually cause an autosomal recessive hyper-IgE syndrome phenotype. Data are lacking about expression of DOCK8 protein in neutrophils or the possible role of DOCK8 in neutrophil function. Read More

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https://www.tandfonline.com/doi/full/10.1080/08820139.2019.1
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http://dx.doi.org/10.1080/08820139.2019.1567533DOI Listing
January 2019
6 Reads

Serum Levels of OPG, RANKL, and RANKL/OPG Ratio in Patients with Ankylosing Spondylitis: A Systematic Review and Meta-analysis.

Immunol Invest 2019 Jan 28:1-15. Epub 2019 Jan 28.

a Department of Epidemiology and Biostatistics, School of Public Health , Anhui Medical University , Hefei , Anhui , China.

Objectives: To investigate the role of osteoprotegerin (OPG), receptor activator of nuclear factor-kB ligand (RANKL), and RANKL/OPG ratio in the pathogenesis of ankylosing spondylitis (AS).

Methods: Studies that compared serum levels of OPG, RANKL, and RANKL/OPG ratio between AS patients and healthy controls were gathered. Pooled standardized mean differences (SMDs) with 95% confidence intervals (CIs) were calculated by the random-effects model. Read More

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http://dx.doi.org/10.1080/08820139.2019.1567531DOI Listing
January 2019
1 Read
1.903 Impact Factor

LPS-induced Apoptosis is Partially Mediated by Hydrogen Sulphide in RAW 264.7 Murine Macrophages.

Immunol Invest 2019 Jan 28:1-15. Epub 2019 Jan 28.

a School BioSciences and Technology , Vellore Institute of Technology, VIT University , Vellore , India.

Lipopolysaccharide (LPS) induces apoptosis in murine macrophages through the autocrine secretion of tumor necrosis factor (TNF)-α and nitric oxide (NO). LPS-induced inflammation in murine macrophages is associated with hydrogen sulfide (HS) production. In this present study, we reported the novel role of HS in LPS-induced apoptosis and its underlying molecular mechanism specifically at late phases in murine macrophage cells. Read More

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https://www.tandfonline.com/doi/full/10.1080/08820139.2019.1
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http://dx.doi.org/10.1080/08820139.2019.1566355DOI Listing
January 2019
2 Reads

TNF May Negatively Regulate Phagocytosis of Devil Facial Tumour Disease Cells by Activated Macrophages.

Immunol Invest 2019 Jan 19:1-13. Epub 2019 Jan 19.

a Menzies Institute for Medical Research, College of Health and Medicine , University of Tasmania , Hobart , Tasmania , Australia.

Introduction: Macrophage phagocytosis of pathogens and tumour cells is an important early event in protection against infectious disease and cancer. As tumour necrosis factor α (TNF) is an important cytokine in macrophage activation, we investigated the involvement of TNF in macrophage phagocytosis of tumour cells.

Methods: We used Devil Facial Tumour Disease (DFTD) cancer cells as the target tumour cells. Read More

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http://dx.doi.org/10.1080/08820139.2018.1515222DOI Listing
January 2019
1 Read

Effects of Soluble Tumor Necrosis Factor (TNF) on Antibody-Dependent Cellular Cytotoxicity of Therapeutic anti-TNF-α Antibody.

Immunol Invest 2018 Dec 20:1-10. Epub 2018 Dec 20.

a Chemicals Assessment and Research Center , Chemicals Evaluation and Research Institute , Saitama , Japan.

Anti-TNF antibodies are major therapeutics for rheumatoid arthritis and have been approved for marketing in many countries. Antibody-dependent cellular cytotoxicity (ADCC) is considered to be a potential mechanism of action of anti-TNF antibodies, since some anti-TNF antibodies have been confirmed to induce cytotoxic effects on TNF-producing cells via ADCC and complement-dependent cytotoxicity (CDC) in in vitro experiments. In this study, we established a new stable effector cell line expressing human FcγRIIIa, CD16:KHYG-1, and compared the performance of this cell line with that of peripheral blood mononuclear cells (PBMCs) in ADCC assays against CHO-derived target cells expressing protease-sensitive pro-TNF. Read More

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http://dx.doi.org/10.1080/08820139.2018.1549067DOI Listing
December 2018
3 Reads

Decreased Gene Expression of Epstein-Barr Virus-Induced Gene 3 (EBI-3) may Contribute to the Pathogenesis of Rheumatoid Arthritis.

Immunol Invest 2018 Dec 4:1-11. Epub 2018 Dec 4.

a Department of Immunology , Kermanshah University of Medical Sciences , Kermanshah , Iran.

Background: Interleukin-35 (IL-35) is a member of the IL-12 family of heterodimeric cytokines produced by regulatory T (Treg) cells. This immunosuppressive cytokine can prevent exaggerated inflammatory responses like those responsible for the development of rheumatoid arthritis (RA). This study aims to determine the correlation between the gene expression of Epstein-Barr virus-induced gene 3 (EBI-3) and IL-12A (p35) subunits of IL-35 in peripheral blood leukocytes with immunological and clinical parameters in RA patients. Read More

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http://dx.doi.org/10.1080/08820139.2018.1549066DOI Listing
December 2018
1 Read
2.588 Impact Factor

Immune Correlates of Protection Induced by Virus-Like Particles Containing 2009 H1N1 Pandemic Influenza HA, NA or M1 Proteins.

Immunol Invest 2018 Nov 15:1-12. Epub 2018 Nov 15.

a Department of Medical Zoology , Kyung Hee University School of Medicine , Seoul , Korea.

Influenza virus-like particle (VLPs) vaccines are a promising alternative to conventional egg-based vaccines. Evaluation of vaccine efficacy induced by HA-M1 VLPs, NA-M1 VLPs or M1 VLPs against virus challenge infection would provide important insight into vaccine design strategy. In this study, we generated VLPs containing hemagglutinin (HA), neuraminidase (NA) or M1 proteins derived from the A/California/04/09. Read More

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http://dx.doi.org/10.1080/08820139.2018.1544640DOI Listing
November 2018
7 Reads

Body Mass Index and Mortality in Elderly Subjects from the Moli-Sani Study: A Possible Mediation by Low-Grade Inflammation?

Immunol Invest 2018 Nov 13;47(8):774-789. Epub 2018 Nov 13.

b Department of Epidemiology and Prevention , IRCCS Neuromed , Pozzilli (IS) , Italy.

The association between obesity and mortality in the elderly remains controversial. To test the association between BMI and mortality, with the hypothesis of a mediation by low-grade inflammation (LGI), a prospective study design (median follow-up 7.8 years) was used on a sample of 4,970 elderly subjects (age ≥ 65 years) from the Moli-sani Study cohort. Read More

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http://dx.doi.org/10.1080/08820139.2018.1538237DOI Listing
November 2018
3 Reads

Characterization of Natural Killer Cells in HIV Patients Beginning Therapy with a High Burden of Cytomegalovirus.

Immunol Invest 2018 Nov 13:1-10. Epub 2018 Nov 13.

a Faculty of Medicine, Virology and Cancer Pathobiology Research Center , Universitas Indonesia , Jakarta , Indonesia.

Background: Active infections with cytomegalovirus (CMV) increase NK cell expression of the inhibitory receptor LIR-1 and the activating receptor NKG2C in transplant recipients. However, the effects of CMV on NK cells are different in HIV patients stable on antiretroviral therapy (ART) and have not been analyzed in young HIV patients beginning ART.

Methodology: We followed a cohort of 78 Indonesian HIV patients beginning ART. Read More

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https://www.tandfonline.com/doi/full/10.1080/08820139.2018.1
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http://dx.doi.org/10.1080/08820139.2018.1538236DOI Listing
November 2018
12 Reads

PD-1 Haplotype Combinations and Susceptibility of Patients to Squamous Cell Carcinomas of Head and Neck.

Immunol Invest 2019 Jan 30;48(1):1-10. Epub 2018 Oct 30.

a Department of Immunology , School of Medicine, Shiraz University of Medical Sciences , Shiraz , Iran.

Introduction: Head and neck squamous cell carcinomas (HNSCCs) are the most common cancers of head and neck and the sixth most common malignancy worldwide. Programmed cell death 1 (PD-1) is an immune inhibitory molecule which through interaction with its ligands recruits protein phosphatase resulting in immune response inhibition. Expression of PD-1 ligands on tumor cells is considered as one of the crucial immune evasion mechanisms. Read More

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https://www.tandfonline.com/doi/full/10.1080/08820139.2018.1
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http://dx.doi.org/10.1080/08820139.2018.1538235DOI Listing
January 2019
2 Reads

Comparative Analysis of Bone Marrow-derived Mast Cell Differentiation in C57BL/6 and BALB/c Mice.

Immunol Invest 2018 Oct 18:1-18. Epub 2018 Oct 18.

a Host Defense for Animals , Nippon Veterinary and Life Science University , Musashino-shi, Tokyo , Japan.

Allergic diseases have increased in the last three decades. Mast cells play a critical role in allergic diseases along with allergen-specific immunoglobulin E (IgE). Following mast cell degranulation elicited by ligation of the IgE-FcεRI receptor complex with allergen, allergic reactions are followed by various symptoms such as vascular hyperpermeability, mucous secretion, itching, sneezing, wheezing, rashes, fever, and anaphylactic shock. Read More

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https://www.tandfonline.com/doi/full/10.1080/08820139.2018.1
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http://dx.doi.org/10.1080/08820139.2018.1523924DOI Listing
October 2018
11 Reads

Thyroglobulin Antibodies are Associated with Symptom Burden in Patients with Hashimoto's Thyroiditis: A Cross-Sectional Study.

Immunol Invest 2019 Feb 17;48(2):198-209. Epub 2018 Oct 17.

b Department of Medical Biology , University of Split, School of Medicine , Split , Croatia.

Background: Hashimoto's thyroiditis (HT) is the most common form of autoimmune thyroid disorders characterized by lower production of thyroid hormones and positivity to autoantibodies to thyroglobulin (TgAb) and/or thyroid peroxidase (TPOAb). We performed a comprehensive phenotypic characterization of patients with HT, with specific focus on thyroid autoimmunity, to get better understanding of disease manifestation.

Methods: We collected information on thyroid-specific phenotypes (TSH, T3, T4, fT4, TgAb, TPOAb, thyroid volume) and other clinical phenotypes (age, body surface area, number of hypothyroidism symptoms, blood pressure) from 290 patients with HT without levothyroxine (LT4) therapy with the aim to test for correlations between thyroid-specific and clinical phenotypes. Read More

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http://dx.doi.org/10.1080/08820139.2018.1529040DOI Listing
February 2019
3 Reads

Association of KIR Genotypes and Haplotypes in HBeAg-positive Chronic Hepatitis B Patients Treated with Entecavir.

Immunol Invest 2018 Oct 16:1-12. Epub 2018 Oct 16.

e Department of Biochemistry and Molecular Biology , Medical college of Shandong University , Jinan , Shandong Province , P. R. China.

Background: A large proportion of patients with chronic hepatitis B (CHB) in China do not respond to entecavir (ETV) treatment. It remains unclear whether the Killer immunoglobulin-like receptor (KIR) genotypes and haplotypes were associated with the advantage of seroconversion in phepatitis B e-Antigen (HBeAg) positive CHB patients treated with ETV.

Methods: Polymerase chain reaction with sequence-specific primers (PCR-SSP) was used to analyze KIR genes in a Chinese Han population of 198 ETV-treated HBeAg-positive CHB patients and 200 healthy controls. Read More

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https://www.tandfonline.com/doi/full/10.1080/08820139.2018.1
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http://dx.doi.org/10.1080/08820139.2018.1529791DOI Listing
October 2018
3 Reads

Evaluation and characteristics of immunological adjuvant activity of purified fraction of Albizia julibrissin saponins.

Immunol Invest 2018 Oct 16:1-20. Epub 2018 Oct 16.

a College of Animal Sciences , Zhejiang University , Hangzhou , Zhejiang China.

Purpose: The purified fraction of Albizia julibrissin saponins (AJSAF) was evaluated and characterized for the adjuvant activity on porcine reproductive and respiratory syndrome virus (PRRSV) vaccine.

Methods: The effects of AJSAF on serum PRRSV N protein-specific antibody titers, splenocyte proliferation, natural killer (NK) cell activity, mRNA expression of cytokines and transcription factors, secretion of cytokines, T cells response in splenocytes, as well as delayed type hypersensitivity (DTH) in the mice immunized PRRSV vaccine were determined by ELISA, MTT assay, flow cytometry and quantitative real-time PCR (qRT-PCR).

Results: AJSAF not only significantly enhanced the serum PRRSV N protein-specific IgG, IgG1, IgG2a and IgG2b antibody titers in the mice immunized with PRRSV CH-1R modified live vaccine (CH-1R MLV), inactivated vaccine (CH-1R IAV), and highly pathogenic JXA1-R modified live vaccine (JXA1-R MLV), but promoted the concanavalin A (Con A)-, lipopolysaccharide (LPS)- and PRRSV N protein-stimulated splenocyte proliferation, the activities of NK cells and delayed type hypersensitivity (DTH) in the mice immunized CH-1R MLV. Read More

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https://www.tandfonline.com/doi/full/10.1080/08820139.2018.1
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http://dx.doi.org/10.1080/08820139.2018.1523923DOI Listing
October 2018
4 Reads

Regulatory T Cells and Their Association with Serum Markers and Symptoms in Systemic Lupus Erythematosus and Rheumatoid Arthritis.

Immunol Invest 2019 Jan 16;48(1):64-78. Epub 2018 Oct 16.

c Department of Biochemistry, Institute of Medical Sciences , Banaras Hindu University , Varanasi , India.

Purpose: Impairment in number and functions of regulatory T cells (Treg) has been found to be associated with many autoimmune diseases including systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA). This study was conducted to identify and compare Treg by flow cytometry using two different staining approaches.

Methods: Treg were identified by using CD4+CD25+high and CD4+CD25+CD127dim staining approaches in SLE and RA patients and healthy controls. Read More

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http://dx.doi.org/10.1080/08820139.2018.1527852DOI Listing
January 2019
1 Read
1.903 Impact Factor

Biological Markers of Oxidative Stress in Cardiovascular Diseases: After so Many Studies, What do We Know?

Immunol Invest 2018 Oct 15:1-21. Epub 2018 Oct 15.

c Department of Pathology , University of Louisville , Louisville , KY USA.

Numerous conditions, including cancer, diabetes, aging, and atherosclerosis, are thought to be associated with oxidative stress. Oxidative stress is defined as a persistent imbalance between oxidation and antioxidation, resulting in the damage of cellular macromolecules and is often considered to be involved in wide variety of human diseases. However, the current literature is very heterogeneous making it rather difficult to draw general conclusions. Read More

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http://dx.doi.org/10.1080/08820139.2018.1523925DOI Listing
October 2018

Association between Toll-Like Receptor 3 (TLR3) rs3775290, TLR7 rs179008, TLR9 rs352140 and Chronic HCV.

Immunol Invest 2018 Oct 15:1-12. Epub 2018 Oct 15.

a Clinical Immunology Unit, Clinical Pathology Department, Mansoura Faculty of Medicine , Mansoura University , Mansoura , Egypt.

Background: Inconsistent results were reported on the association of TLRs polymorphisms with the risk of HCV infection and HCV-related diseases.

Objective: to assess the relation between TLR3 rs3775290, TLR7 rs17900 and TLR9 rs352140 SNPs and chronic HCV in the Egyptian cohort and to study their relation to interferon response.

Methods: TLR3 rs3775290, TLR7 rs179008 and TLR9 rs352140 gene polymorphisms were typed by RFLP for 100 patients with chronic HCV and 25 with HCC in addition to 100 healthy controls. Read More

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http://dx.doi.org/10.1080/08820139.2018.1527851DOI Listing
October 2018

Antigen-Presenting Cell Characteristics of Human γδ T Lymphocytes in Chronic Myeloid Leukemia.

Immunol Invest 2019 Jan 15;48(1):11-26. Epub 2018 Oct 15.

a Center for Research and Innovation, Faculty of Medical Technology , Mahidol University , Bangkok , Thailand.

Human γδ T lymphocytes play a role in the immune system defense against cancer. Their broad anti-cancer activity against different types of cancers makes them outstanding candidates for cancer immunotherapy. An issue of recent interest is whether their antigen presentation features are similar to mature dendritic cells. Read More

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https://www.tandfonline.com/doi/full/10.1080/08820139.2018.1
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http://dx.doi.org/10.1080/08820139.2018.1529039DOI Listing
January 2019
4 Reads

Adipokines in Multiple Sclerosis Patients with and without Optic Neuritis as the First Clinical Presentation.

Immunol Invest 2019 Feb 15;48(2):190-197. Epub 2018 Oct 15.

c Department of Neuroscience Institute for Experimental Medicine , Istanbul University , Istanbul , Turkey.

Background: Adipocytokines have been implied to be involved in multiple sclerosis (MS) pathogenesis. MS patients whose first clinical episode is optic neuritis (ON) have been reported to display a milder disease course. In this study, we aimed to show whether this milder disease course is related to reduced adipokine production. Read More

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http://dx.doi.org/10.1080/08820139.2018.1528270DOI Listing
February 2019
1 Read

The Relationship of COX-2 Gene Polymorphisms and Susceptibility to Kawasaki Disease in Chinese Population.

Immunol Invest 2019 Feb 15;48(2):181-189. Epub 2018 Oct 15.

a Department of Pediatrics , The Third Xiangya Hospital of Central South University , Changsha , Hunan China.

Background: Kawasaki disease (KD) is an acute systemic vasculitis that predominantly affects children, and it can result in coronary artery lesions. Cyclooxygenase-2 (COX-2) is involved in the conversion of arachidonic acid to prostaglandin H2, an important precursor of several prostaglandins. The aim of this study was to examine the association between COX-2 gene polymorphisms and susceptibility to KD. Read More

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http://dx.doi.org/10.1080/08820139.2018.1529790DOI Listing
February 2019
1 Read

Genetic Relationship Between IL-6 rs1800796 Polymorphism and Susceptibility to Periodontitis.

Immunol Invest 2018 Oct 9:1-15. Epub 2018 Oct 9.

a Dental Department , Tianjin First Center Hospital , Tianjin , People's Republic of China.

Background: There are accumulating reports for the potential role of Interleukin-6 (IL-6) rs1800796 polymorphism in the risk of periodontitis. However, distinct conclusions are observed. In this study, we have an interest in comprehensively analyzing the genetic relationship between IL-6 rs1800796 and the susceptibility to periodontitis. Read More

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https://www.tandfonline.com/doi/full/10.1080/08820139.2018.1
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http://dx.doi.org/10.1080/08820139.2018.1517365DOI Listing
October 2018
2 Reads

Analysis of the Association of Polymorphisms rs5743708 in TLR2 and rs4986790 in TLR4 with Atopic Dermatitis Risk.

Immunol Invest 2019 Feb 1;48(2):169-180. Epub 2018 Oct 1.

a Department of Dermatology , Shengli Oilfield Central Hospital , Shandong , China.

Background: We carried out a meta-analysis to assess whether Toll-like receptor 2 (TLR2) rs5743708 and Toll-like receptor 4 (TLR4) rs4986790 polymorphisms are associated with the risk of atopic dermatitis.

Methods: A systematic search of PubMed, Embase, and Web of Science was performed to identify eligible case-control studies on the association of rs5743708 and rs4986790 with the risk of atopic dermatitis. Statistical analyses of the odds ratio (OR), 95% confidence interval (CI), and p value were performed using STATA software. Read More

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http://dx.doi.org/10.1080/08820139.2018.1508228DOI Listing
February 2019
1 Read
1.903 Impact Factor

HLA Class I in Egyptian patients with Behçet's disease: new association with susceptibility, protection, presentation and severity of manifestations.

Immunol Invest 2019 Feb 27;48(2):121-129. Epub 2018 Sep 27.

a Rheumatology and Rehabilitation Department , Cairo University , Cairo , Egypt.

Introduction: Behçet's disease is an autoimmune disease with diverse clinical manifestations with vasculitis being the hallmark of the disease. The aim of this work is to study the genetic association between human leukocyte antigen (HLA) class-I molecules of Egyptians with Behçet's disease and the disease susceptibility and clinical patterns.

Methods: Fifty-seven patients diagnosed with Behçet's disease according to the 1990 International Study Group (ISG) criteria for Behçet's disease coming from Egyptian origin up to the third grandfather were included in the study. Read More

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http://dx.doi.org/10.1080/08820139.2018.1517364DOI Listing
February 2019
1 Read
1.903 Impact Factor

miR-350-3p Contributes to Age-Associated Impairment of IL-6 Production by Macrophages.

Immunol Invest 2018 Sep 27:1-11. Epub 2018 Sep 27.

a Department of Cardiology , The First Affiliated Hospital, Cardiovascular Institute, Harbin Medical University , Harbin , P.R. China.

Aging-associated dysfunction of the immune system contributes to the increase in pathophysiological processes that occur with age. Numerous studies have shown that microRNAs regulate immune responses, although their role in age-related macrophage dysfunction remains elusive. Here, we found that miR-350-3p is expressed at lower levels in peritoneal macrophages from aged mice compared with young mice, and that lipopolysaccharide (LPS) stimulation downregulates miR-350-3p expression to a greater extent in young macrophages compared with aged macrophages. Read More

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http://dx.doi.org/10.1080/08820139.2018.1508227DOI Listing
September 2018
1 Read

Direct Engagement of TLR9 Ligand with T Helper Cells Leads to Cell Proliferation & Up-regulation of Cytokines.

Immunol Invest 2019 Jan 21;48(1):79-95. Epub 2018 Sep 21.

a Advanced Eye Center , Post graduate Institute of Medical Education and Research , Chandigarh , India.

Purpose: Toll like receptor (TLR) engagement is primarily a function of the innate immune cells. The purpose of the study was to assess direct uptake of ODN 2216 in T helper cells and effects on cell proliferation and cytokine expression.

Methods: We isolated CD4+ CD25- T helper cells by magnetic sorting and studied the uptake of ODN 2216 using flow cytometry and confocal microscopy. Read More

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http://dx.doi.org/10.1080/08820139.2018.1515223DOI Listing
January 2019
1 Read
1.903 Impact Factor

Enhanced Anti-Leukemic Effects through Induction of Immunomodulating Microenvironment by Blocking CXCR4 and PD-L1 in an AML Mouse Model.

Immunol Invest 2019 Jan 11;48(1):96-105. Epub 2018 Sep 11.

a Leukemia Research Institute, Seoul St. Mary's Hospital, College of Medicine , The Catholic University of Korea , Seoul , Korea.

Previously, we found that dual therapy by the CXCR4 inhibitor Plerixafor and cytosine arabinoside (Ara-C) effectively eradicated leukemia cells and concurrently activated immune cells in acute myeloid leukemia (AML). To reveal the significance of programmed death-ligand1 (PD-L1) in AML and as a strategic approach, we investigated the anti-leukemic effect of a triple combinational therapy by utilizing Plerixafor and anti-PD-L1 in combination with chemotherapy in an AML mouse model. We examined leukemic myeloid blast cells in multiple organs after the successive treatment with Ara-C, Plerixafor, and anti-PD-L1. Read More

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http://dx.doi.org/10.1080/08820139.2018.1497057DOI Listing
January 2019
13 Reads
1.903 Impact Factor

Impact of IL-27p28 (rs153109) and TNF-α (rs1800629) Genetic Polymorphisms on the Progression of HCV Infection in Egyptian Patients.

Immunol Invest 2018 Sep 11:1-13. Epub 2018 Sep 11.

a Department of Biochemistry, Pharmacy , Minia University , Minia , Egypt.

Background: Hepatitis C virus (HCV) is a universal health problem. HCV infection may proceed to liver fibrosis, cirrhosis, and eventually hepatocellular carcinoma (HCC). The latest is the third leading global cause of cancer-related mortality. Read More

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http://dx.doi.org/10.1080/08820139.2018.1510958DOI Listing
September 2018
2 Reads

Mussel adhesive Protein-conjugated Vitronectin (fp-151-VT) Induces Anti-inflammatory Activity on LPS-stimulated Macrophages and UVB-irradiated Keratinocytes.

Immunol Invest 2018 Sep 6:1-13. Epub 2018 Sep 6.

a Biotechnology & Business Center , Incheon Business Information Technopark , Incheon , Republic of Korea.

Background: Skin inflammation and dermal injuries are a major clinical problem because current therapies are limited to treating established scars, and there is a poor understanding of healing mechanisms. Mussel adhesive proteins (MAPs) have great potential in many tissue engineering and biomedical applications. It has been successfully demonstrated that the redesigned hybrid type MAP (fp-151) can be utilized as a promising adhesive biomaterial. Read More

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https://www.tandfonline.com/doi/full/10.1080/08820139.2018.1
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http://dx.doi.org/10.1080/08820139.2018.1506476DOI Listing
September 2018
23 Reads

Circulating Levels of Osteoprotegerin, Osteocalcin and Osteopontin in Patients with Rheumatoid Arthritis: A Systematic Review and Meta-Analysis.

Immunol Invest 2019 Feb 6;48(2):107-120. Epub 2018 Sep 6.

a Department of Epidemiology and Biostatistics , School of Public Health, Anhui Medical University , Hefei , Anhui , China.

Objective: Currently published data regarding the potential role of osteoprotegerin (OPG), osteocalcin (OCN) and osteopontin (OPN) for the discrimination between rheumatoid arthritis (RA) and osteoarthritis (OA) are contradictory. To derive a more precise evaluation, a meta-analysis was performed.

Methods: Published literatures comparing plasma/serum OPG, OCN and OPN levels between RA group and OA controls were searched in PubMed, Embase and the Cochrane Library. Read More

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http://dx.doi.org/10.1080/08820139.2018.1510957DOI Listing
February 2019
3 Reads

Therapeutic Use of Intrathecal Mesenchymal Stem Cells in patients with Multiple Sclerosis: A Pilot Study with Booster Injection.

Immunol Invest 2019 Feb 29;48(2):160-168. Epub 2018 Aug 29.

a MS Research Center, Neuroscience Institute , Tehran University of Medical sciences , Tehran , Iran.

Background: Mesenchymal stem cells (MSCs) are a potential therapy for various diseases. Here, the results of intrathecal injection of MSCs in multiple sclerosis (MS) patients are reported.

Materials And Methods: Four patients were enrolled in the study. Read More

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http://dx.doi.org/10.1080/08820139.2018.1504301DOI Listing
February 2019
2 Reads

Genetic Analysis of Patients with Two Different Types of Hyper IgM Syndrome.

Immunol Invest 2018 Oct 6;47(7):745-753. Epub 2018 Aug 6.

a Immunology, Asthma & Allergy Research Institute , Tehran University of Medical Sciences , Tehran , Iran.

Background: Hyper IgM Syndrome (HIGM) is a rare primary immunodeficiency in which impairment of class switching recombination (CSR) and somatic hyper-mutation (SHM) leads to recurrent infections.

Objectives: The aim of this study is to report the clinical and genetic features of six Iranian HIGM patients.

Methods: Six patients, who suspected to have HIGM based on two clinical findings, including recurrent infections and low levels of IgG and IgA and normal or elevated levels of IgM, were entered this study to undergo genetic studies. Read More

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https://www.tandfonline.com/doi/full/10.1080/08820139.2018.1
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http://dx.doi.org/10.1080/08820139.2018.1493052DOI Listing
October 2018
4 Reads

Anti-α-galactoside and Anti-β-glucoside Antibodies are Partially Occupied by Either of Two Albumin-bound O-glycoproteins and Circulate as Ligand-binding Triplets.

Immunol Invest 2018 Aug 6:1-20. Epub 2018 Aug 6.

a Department of Biochemistry , Sree Chitra Tirunal Institute for Medical Sciences and Technology , Thiruvananthapuram - India.

Two heavily O-glycosylated proteins and albumin co-purified with anti-α-galactoside (anti-Gal), the chief xenograft-rejecting antibody and anti-β-glucan (ABG) antibody isolated from human plasma by affinity chromatography on respective ligand-bearing matrices. Both antibodies and O-glycoproteins co-purified with plasma albumin eluted from albumin-specific matrix. Using components of affinity-purified antibody samples separated by electrophoresis binding of either albumin or antibody to the affinity matrix of the other or binding of O-glycoprotein to either matrix was ruled out. Read More

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http://dx.doi.org/10.1080/08820139.2018.1502299DOI Listing

IL-17A and IL-23: plausible risk factors to induce age-associated inflammation in Alzheimer's disease.

Immunol Invest 2018 Aug 6:1-11. Epub 2018 Aug 6.

a Immunology of Infectious Diseases Research Center, Research Institute of Basic Medical Sciences , Rafsanjan University of Medical Sciences , Rafsanjan , Iran.

Background: Aging and its complications such as Alzheimer's disease (AD) are associated with chronic low-grade inflammation entitled age-associated inflammation. However, the main mechanisms whichinduce age-associated inflammation in aging and AD are yet to beclarified. L-23/IL-17A axis plays important roles in the induction of inflammation and consequently autoimmune disease. Read More

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http://dx.doi.org/10.1080/08820139.2018.1504300DOI Listing
August 2018
1 Read

RNA protein kinase SNP at -226 C

Immunol Invest 2018 Aug 6:1-11. Epub 2018 Aug 6.

e Department of Microbiology and Immunology, Faculty of Medicine , Minia University , Minia , Egypt.

Background: RNA-dependant protein kinase R (PKR) is a primary mediator in the defence mechanism of interferon against viral replication and pathogenesis during Hepatitis C virus (HCV) infection. In the present study, we have examined the role of Single Nucleotide Polymorphisms (SNPs) in the promoter region of PKR and the serum level of the same protein on the outcome of HCV-infected Egyptian patients.

Patients And Methods: Genomic DNA was extracted from a total of 135 subjects, including 15 healthy controls, 40 HCV spontaneous resolvers (SRs), and 80 patients with chronic HCV infection. Read More

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http://dx.doi.org/10.1080/08820139.2018.1493496DOI Listing
August 2018
1 Read

Comparison of the Percentage of Regulatory T cells and their p-STAT5 Expression in Allergic and Non-Allergic Common Variable Immunodeficiency Patients.

Immunol Invest 2019 Jan 31;48(1):52-63. Epub 2018 Jul 31.

a Department of Immunology, Faculty of medicine , Isfahan University of Medical Sciences , Isfahan , Iran.

Background: Common Variable Immunodeficiency (CVID) is a primary immunodeficiency characterized by an immunologic deficiency in immunoglobulin production. Regulatory T cells (Tregs) play a key role in preventing the development allergic disorders. p-STAT5 is a known factor for the function and survival of Tregs. Read More

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http://dx.doi.org/10.1080/08820139.2018.1498882DOI Listing
January 2019
5 Reads

A Positive Feedback Loop Between Th17 Cells and Dendritic Cells in Patients with Endplate Inflammation.

Immunol Invest 2019 Jan 17;48(1):39-51. Epub 2018 Jul 17.

c Department of Orthopedics , Putuo Hospital, Shanghai University of Traditional Chinese Medicine , Shanghai , China.

Background: Endplate inflammation remains a difficult disease to treat, in part due to its unclear pathology. Previous experiments showed that patients with idiopathic inflammation presented a systemic upregulation of Th17 cells. Here, we investigated how this change might affect the inflammatory environment in endplate inflammation. Read More

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http://dx.doi.org/10.1080/08820139.2018.1496097DOI Listing
January 2019
6 Reads

Association of HLA-DRB1 and -DQB1 alleles with type 1 (autoimmune) diabetes in African Arabs: systematic review and meta-analysis.

Immunol Invest 2019 Feb 13;48(2):130-146. Epub 2018 Jul 13.

a Department of Immunogenetics , National Blood Transfusion Center , Tunis , Tunisia.

Several studies confirmed the association of HLA-DRB1 and -DQB1 alleles with altered risk of type 1 diabetes (T1D). However, data from individual studies based on small sample sizes yielded often conflicting findings in African Arabs. This is a systematic review and meta-analysis aimed at comprehensively evaluating this association with T1D, using molecular HLA data. Read More

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http://dx.doi.org/10.1080/08820139.2018.1493498DOI Listing
February 2019
3 Reads
1.903 Impact Factor

The Effect of Intravenous Selenium on Oxidative Stress in Critically Ill Patients with Acute Respiratory Distress Syndrome.

Immunol Invest 2019 Feb 12;48(2):147-159. Epub 2018 Jul 12.

d Department of Anesthesiology , University at Buffalo , Buffalo , NY , USA.

Objective: To modulate the inflammatory response in respiratory distress syndrome (ARDS) with selenium.

Background: Selenium replenishes the glutathione peroxidase proteins that are the first line of defense for an oxidative injury to the lungs.

Methods: Forty patients with ARDS were randomized into two groups: the SEL group being administered sodium selenite and the SEL group receiving normal saline for 10 days. Read More

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http://dx.doi.org/10.1080/08820139.2018.1496098DOI Listing
February 2019
7 Reads

Letter from the Editor June 2018.

Immunol Invest 2018 08;47(6):543-546

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http://dx.doi.org/10.1080/08820139.2018.1473920DOI Listing

Interleukin-4 and Interleukin-4 Receptor Alpha Gene Polymorphisms in Recurrent Aphthous Stomatitis.

Immunol Invest 2018 Oct 9;47(7):680-688. Epub 2018 Jul 9.

i Research Center for Immunodeficiencies, Children's Medical Center , Tehran University of Medical Sciences , Tehran , Iran.

Background: Recurrent aphthous stomatitis (RAS) is a common oral condition with a major impact on the quality of life. The condition is thought to be due to the overexpression of T helper-1(Th1)-related cytokines. Since interleukin-4 (IL-4) and its receptor (IL-4Rα) are antagonistic to Th-1 pathways, polymorphisms in their genes may also be involved in the pathogenesis of aphthous stomatitis. Read More

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http://dx.doi.org/10.1080/08820139.2018.1480033DOI Listing
October 2018
7 Reads
1.903 Impact Factor

Defective Treg response in acute kidney injury was caused by a reduction in TIM-3 Treg cells.

Immunol Invest 2019 Jan 9;48(1):27-38. Epub 2018 Jul 9.

c Department of Critical Care Medicine , Shanghai Corps Hospital, Chinese People's Armed Police Forces , Shanghai , China.

Background: Despite years of research, the treatment of acute kidney injury (AKI) remains a significant challenge. Animal studies presented causal links between elevated regulatory T cell (Treg) response and better prognosis in AKI. Previous studies in mice and humans showed that TIM-3+ Treg cells were more potent than TIM-3- Treg cells. Read More

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https://www.tandfonline.com/doi/full/10.1080/08820139.2018.1
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http://dx.doi.org/10.1080/08820139.2018.1493497DOI Listing
January 2019
14 Reads

Association of IL17 and IL23R gene polymorphisms with rheumatic heart disease in South Indian population.

Immunol Invest 2018 Oct 9;47(7):754-764. Epub 2018 Jul 9.

a Department of Immunology , School of Biological Sciences, Madurai Kamaraj University , Madurai , Tamil Nadu , India.

Background: IL-23/Th17 signaling pathway plays a crucial role in the cell-mediated immune response against bacterial infections and also in the pathogenesis of inflammatory and autoimmune diseases. Recent studies indicate that Th17 cell-associated cytokines are involved in the progression and maintenance of valvular lesions in rheumatic heart disease (RHD). Variants in the genes of cytokines that are potentially involved in Th17 response may influence interindividual differences in their expression levels, thereby contributing to the pathogenesis of immune-mediated diseases such as RHD. Read More

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http://dx.doi.org/10.1080/08820139.2018.1493053DOI Listing
October 2018
17 Reads

Serum of Patients with Psoriasis Modulates the Production of MMP-9 and TIMP-1 in Cells of Monocytic Lineage.

Immunol Invest 2018 Oct 6;47(7):725-734. Epub 2018 Jul 6.

a Department of Immunology , Instituto Nacional de Cardiología Ignacio Chávez , Mexico City , Mexico.

Psoriasis is triggered by several stimuli that share a systemic production of interferon (IFN)-γ and other inflammatory mediators, which are key to regulate the production of matrix metalloproteinase (MMP)-9 and its inhibitor (TIMP)-1 by cells of monocytic lineage. This study evaluates the effect of the sera of 55 patients with psoriasis and 41 non-psoriatic individuals on the production of MMP-9 and TIMP-1 in cultured monocytes from a single healthy blood donor and in U937 cells. The effect of IFN-γ stimulation was also evaluated. Read More

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http://dx.doi.org/10.1080/08820139.2018.1489831DOI Listing
October 2018

Association between HLA class II alleles and hepatitis B virus infection in Transylvania, Romania.

Immunol Invest 2018 Oct 6;47(7):735-744. Epub 2018 Jul 6.

b Molecular Biology Laboratory , Legal Medicine Institute , Cluj-Napoca , Romania.

Infection with hepatitis B virus (HBV) is a major problem worldwide. The major histocompatibility complex plays an essential role in host immunity and can help eliminate the HBV of infected hepatocytes. Our study aimed to determine the role of certain human leukocyte antigen (HLA) class II molecules (i. Read More

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http://dx.doi.org/10.1080/08820139.2018.1489832DOI Listing
October 2018
5 Reads

Genetic variant association of PTPN22, CTLA4, IL2RA, as well as HLA frequencies in susceptibility to alopecia areata.

Immunol Invest 2018 Oct 6;47(7):666-679. Epub 2018 Jul 6.

c Urogenital Stem Cell Research Center , Shahid Beheshti University of Medical Sciences , Tehran , Iran.

Alopecia areata (AA) is characterized by a genetically complex inheritance. HLA frequencies, as well as the single nucleotide polymorphism (SNP) in PTPN22, CTLA4, and IL2RA genes, have been described to be associated with AA susceptibility. So far, no independent replication of these studies has been reported, and no data exist on a possible association between AA disease and these SNPs or influence of HLA frequencies in Iranian population. Read More

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http://dx.doi.org/10.1080/08820139.2018.1480032DOI Listing
October 2018

Association between HLA-G 14bp Gene Polymorphism and Serum sHLA-G Protein Concentrations in Preeclamptic Patients and Normal Pregnant Women.

Immunol Invest 2018 Aug 28;47(6):558-568. Epub 2018 Jun 28.

c Department of Medical Genetics, School of Medicine , Ahvaz Jundishapur University of Medical Sciences , Ahvaz , Iran.

Background: Preeclampsia (PE) is a multisystem syndrome that is a primary source of fetal-maternal morbidity and mortality. Human leukocyte antigen-G (HLA-G) is a nonclassical Major histocompatibility complex (MHC) class-Ib molecule expressed on the extravillous trophoblast and seems to have immunomodulatory functions during pregnancy. The purpose of our study was to investigate whether HLA-G may be a vital marker in the modulation of the pregnancy. Read More

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http://dx.doi.org/10.1080/08820139.2018.1467925DOI Listing
August 2018
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Exogenous IL-9 Ameliorates Experimental Autoimmune Myasthenia Gravis Symptoms in Rats.

Immunol Invest 2018 Oct 26;47(7):712-724. Epub 2018 Jun 26.

b Department of Neurobiology, Heilongjiang Province Key Lab of Neurobiology , Harbin Medical University , Harbin , Heilongjiang , China.

Interleukin-9 (IL-9) is a multifunctional cytokine involved in protective immunity or immunopathology depending on the microenvironment and specific disease settings. Our early study determined that IL-9 and Th9 cells participate in and promote the progression of experimental autoimmune myasthenia gravis (EAMG). The data from this study showed that exogenous recombinant rat IL-9 (rrIL-9) acted as an IL-9 receptor antagonist, reduced the incidence of EAMG in rats, alleviated the severity of the disease, and reduced the anti-acetylcholine receptor (AChR) IgG antibody levels by altering the Th-subset distribution. Read More

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https://www.tandfonline.com/doi/full/10.1080/08820139.2018.1
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http://dx.doi.org/10.1080/08820139.2018.1487976DOI Listing
October 2018
19 Reads

Intensified Th9 Response is Associated with the Immunopathogenesis of Active Ulcerative Colitis.

Immunol Invest 2018 Oct 21;47(7):700-711. Epub 2018 Jun 21.

c Department of Internal Medicine , Shahrekord University of Medical Sciences , Shahrekord , Iran.

Background: Ulcerative colitis (UC) is a chronic inflammatory disorder of the large intestine histologically characterized by indistinct sustained inflammatory responses. Genetical susceptibility and environmental factors' effects play the roles in disease occurrence and it can be life threatening if remains untreated. It seems that intensification of inflammatory responses in this condition is not restricted to a specific cell line of T lymphocytes. Read More

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http://dx.doi.org/10.1080/08820139.2018.1486411DOI Listing
October 2018
3 Reads

Immunological examination of peripheral blood in patients with colorectal cancer compared to healthy controls.

Immunol Invest 2018 Oct 20;47(7):643-653. Epub 2018 Jun 20.

a Department of Oncology, First Faculty of Medicine , Charles University , Prague , Czech Republic.

Background: The objective of this study was to investigate serum levels of immunosuppressive cytokines TGF beta 1 and VEGF and count of immune cells in peripheral blood in stage II and III colorectal cancer patients.

Methods: Blood samples were collected from 22 colorectal patients and 25 healthy controls before the start of treatment. All patients were examined by a clinical immunologist to exclude patients with immune disorders and autoimmune diseases. Read More

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https://www.tandfonline.com/doi/full/10.1080/08820139.2018.1
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http://dx.doi.org/10.1080/08820139.2018.1480030DOI Listing
October 2018
4 Reads