2,016 results match your criteria Immunologic Research [Journal]


Patients with atopy exhibit reduced cortisol awakening response but not cortisol concentrations during the rest of the day.

Immunol Res 2019 Apr 22. Epub 2019 Apr 22.

Laboratory of Pharmacological Neuroendocrinology, Institute of Experimental Endocrinology, Biomedical Research Center of the Slovak Academy of Sciences, Bratislava, Slovakia.

It has been documented that cortisol release in response to acute stressors is reduced in patients with atopic dermatitis, allergic rhinitis, and other atopic diseases compared to that in healthy subjects. We aimed to test the hypothesis that atopic patients exert reduced salivary cortisol awakening response (CAR) in comparison with healthy subjects. The hypothesis was tested on a stressful and a relax day selected subjectively. Read More

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http://dx.doi.org/10.1007/s12026-019-09076-wDOI Listing

Putative loss of CD83 immunosuppressive activity in long-standing complication-free juvenile diabetic patients during disease progression.

Immunol Res 2019 Feb;67(1):70-76

Department of Medical Immunology, Laboratory of Experimental Immunology, Medical University of Gdańsk, Dębinki 1, 80-211, Gdańsk, Poland.

The CD83 molecule is a known marker of dendritic cell differentiation process, and its soluble form (sCD83) exerts immunosuppressive functions. In our research, we examined whether the sCD83 plasma concentration is impaired in DM1 children and if the expected changes are in line with the disturbed process of monocyte's transformation into mCD83 monocyte-derived cells. 28 newly diagnosed (ND-DM1) and 30 long-standing (LS-DM1) patients were enrolled into our study. Read More

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http://link.springer.com/10.1007/s12026-019-09074-y
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http://dx.doi.org/10.1007/s12026-019-09074-yDOI Listing
February 2019
2 Reads

The emerging role of STING-dependent signaling on cell death.

Immunol Res 2019 Mar 13. Epub 2019 Mar 13.

Department of Gastrointestinal Surgery, Nanjing Drum Tower Hospital, Nanjing University Medical School, 321 Zhongshan RD, Nanjing, 210008, China.

STING is a newly identified adaptor protein for sensing cytosolic nucleic acid. It is well established that STING plays a crucial role in innate immune response via inducing production of type I IFN. Emerging evidence suggests that the activation of STING-dependent signaling is also implicated in the process of cell death, such as apoptosis, pyroptosis, necroptosis, and autophagy. Read More

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http://dx.doi.org/10.1007/s12026-019-09073-zDOI Listing

Editorial: autoimmunity-the ever endless world.

Authors:
Elias Toubi

Immunol Res 2018 Dec;66(6):633-636

Division of Allergy and Clinical Immunology, Bnai-Zion Medical Center, Technion, Haifa, Israel.

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http://dx.doi.org/10.1007/s12026-019-09071-1DOI Listing
December 2018
1 Read

Monocytes of newly diagnosed juvenile DM1 patients are prone to differentiate into regulatory IL-10 M2 macrophages.

Immunol Res 2019 Feb;67(1):58-69

Department of Medical Immunology, Laboratory of Experimental Immunology, Medical University of Gdańsk, Dębinki 1, 80-211, Gdańsk, Poland.

Alternatively activated macrophages (M2) exert anti-inflammatory effects and are crucial for keeping balance between protective and destructive cell-mediated immunity in healing phase of inflammation. Two members of the interferon regulatory factors family, IRF5 and IRF4, are known to promote M1 or M2 phenotype, respectively. Our study aimed to analyse the effectiveness of the M2 differentiation process in vitro (achieved by IL-4 stimulation) and its relationship to the stage of type 1 diabetes mellitus (DM1) in juvenile patients. Read More

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http://dx.doi.org/10.1007/s12026-019-09072-0DOI Listing
February 2019

Consideration concerning similarities and differences between ANCA-associated vasculitis and IgG-4-related diseases: case series and review of literature.

Immunol Res 2019 Feb;67(1):99-107

Department of Rheumatology and Allergy, Japanese Red Cross Society Narita Hospital, 90-1, Iida-cho, Narita-shi, Chiba, 286-8523, Japan.

Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) and immunoglobulin G4-related diseases (IgG4-RD) are regarded as entirely different disease types with different etiological mechanisms. However, we experienced two cases that had clinical features of both AAV and IgG4-RD. The first case is an 81-year-old woman who showed periaortitis and retroperitoneal fibrosis and periarteritis with elevation of myeloperoxidase-anti-neutrophil cytoplasmic antibody and IgG4 levels. Read More

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http://dx.doi.org/10.1007/s12026-019-9070-7DOI Listing
February 2019
3 Reads
3.098 Impact Factor

Suspected adverse effects after human papillomavirus vaccination: a temporal relationship.

Immunol Res 2018 Dec;66(6):723-725

Department of Medicine (Neurology and Rheumatology), Shinshu University School of Medicine, Matsumoto, 390-8621, Japan.

In Japan, a significant number of adolescent girls complained unusual symptoms after human papillomavirus (HPV) vaccination, and the vast majority of them were initially diagnosed as having psychiatric illness because of the absence of pathologic findings, radiological images and specific abnormalities in laboratory test results. Later, these symptoms were supposed to be adverse effects after HPV vaccination, and the recommendation for HPV vaccination was withdrawn by Japanese Ministry of Public Health, Labour and Welfare 4 years and 9 months ago. However, a causal link has not been demonstrated between HPV vaccination and the development of these symptoms. Read More

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http://link.springer.com/10.1007/s12026-018-9063-y
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http://dx.doi.org/10.1007/s12026-018-9063-yDOI Listing
December 2018
7 Reads

Expression of human REG family genes in inflammatory bowel disease and their molecular mechanism.

Immunol Res 2018 Dec;66(6):800-805

Department of Diagnostic Pathology, Nara Medical University, Kashihara, Japan.

The pathophysiology of inflammatory bowel disease (IBD) reflects a balance between mucosal injury and reparative mechanisms. Some regenerating gene (Reg) family members have been reported to be expressed in Crohn's disease (CD) and ulcerative colitis (UC) and to be involved as proliferative mucosal factors in IBD. However, expression of all the REG family genes in IBD is still unclear. Read More

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http://dx.doi.org/10.1007/s12026-019-9067-2DOI Listing
December 2018
1 Read

A novel third-generation TSH receptor antibody (TRAb) enzyme-linked immunosorbent assay based on a murine monoclonal TSH receptor-binding antibody.

Immunol Res 2018 Dec;66(6):768-776

Department of Nuclear Medicine, University Hospital Carl Gustav Carus, Technische Universität Dresden, Fetscherstr 74, 01307, Dresden, Germany.

TSH receptor (TSHR) autoantibody (TRAb) is the serological hallmark of Graves' disease (GD). Third-generation enzyme-linked immunosorbent assays (ELISAs) using monoclonal TRAbs instead of TSH have been found useful for TRAb analysis recently. For the first time, a mouse monoclonal antibody (mAb) against TSHR was analyzed for TRAb detection and compared with human mAb M22 and TSH by the same competitive binding assay technique. Read More

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http://dx.doi.org/10.1007/s12026-018-9062-zDOI Listing
December 2018
1 Read

Tryptophan-kynurenine profile in pediatric autoimmune hepatitis.

Immunol Res 2019 Feb;67(1):39-47

Children's Memorial Health Institute, Warsaw, Poland.

The impairment of regulatory T cells (Tregs) is a characteristic feature of autoimmune hepatitis (AIH), and the degradation of tryptophan (Trp) to kynurenine (Kyn), by gamma interferon-induced indoleamine-2,3-dioxygenase-1 (IDO-1), is a central metabolomics check point in the differentiation of Tregs. For this reason, we investigate whether or not Kyn and IDO activity is potentially useful biomarkers in pediatric AIH.Between January 2016 and January 2017, children of AIH type-1 (AIH-1, n = 37), AIH type-2 with liver kidney microsome-1 autoantibodies (AIH-2-LKM-1, n = 8), and autoantibody-negative Wilsons Disease (WD, n = 8) and alpha-1 anti-trypsin deficiency (AATD, n = 10), were enrolled in a cross-sectional survey of Kyn and Trp levels and Kyn/Trp ratios (IDO activity) by HPLC, and neopterin levels by ELISA. Read More

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http://link.springer.com/10.1007/s12026-019-9068-1
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http://dx.doi.org/10.1007/s12026-019-9068-1DOI Listing
February 2019
10 Reads
3.098 Impact Factor

Macrophage phenotype bioengineered by magnetic, genetic, or pharmacologic interference.

Immunol Res 2019 Feb;67(1):1-11

The Houston Methodist Research Institute, Houston, TX, 77030, USA.

In all eukaryotes, the cell shape depends on the actin filament cytoskeleton, which is regulated by the small GTPase RhoA. It is well known that the cell shape determines cell function and behavior. Inversely, any change in the cell behavior and/or function reverberates at the cell shape. Read More

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http://link.springer.com/10.1007/s12026-019-9066-3
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http://dx.doi.org/10.1007/s12026-019-9066-3DOI Listing
February 2019
14 Reads

Potential roles of neutrophils in maintaining the health and productivity of dairy cows during various physiological and physiopathological conditions: a review.

Immunol Res 2019 Feb;67(1):21-38

Lactation and Immuno-Physiology Laboratory, ICAR-National Dairy Research Institute, Karnal, Haryana, 132 001, India.

Neutrophils represent the first line of innate immunity and are the most prominent line of cellular defence against invading microorganisms. On stimulation, they can quickly move through the walls of veins and into the tissues of the body to immediately attack or monitor the foreign antigens. Neutrophils are highly versatile and sophisticated cells which are endowed with highly sensitive receptor-based perception systems. Read More

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http://dx.doi.org/10.1007/s12026-019-9064-5DOI Listing
February 2019
4 Reads

The relationship between pemphigus and systemic lupus erythematosus: a cross-sectional study, systematic review, and meta-analysis.

Immunol Res 2019 Feb;67(1):116-122

Department of Quality Measurements and Research, Chief Physician's Office, Clalit Health Services, Tel Aviv, Israel.

The coexistence of pemphigus and systemic lupus erythematosus (SLE) had been reported anecdotally. Anti-desmoglein (Dsg)1 and anti-Dsg3 antibodies were detected concomitantly with antinuclear autoantibodies among blood donors. The aim of the current study was to study the association between pemphigus and SLE in Israeli patients and to synthesize existing data on this association in the current literature. Read More

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http://link.springer.com/10.1007/s12026-019-9065-4
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http://dx.doi.org/10.1007/s12026-019-9065-4DOI Listing
February 2019
12 Reads

Concentrations of immunoglobulin free light chains in cerebrospinal fluid predict increased level of brain atrophy in multiple sclerosis.

Immunol Res 2018 Dec;66(6):761-767

City Center of Multiple Sclerosis and Autoimmune Diseases, Municipal Clinical Hospital No 31, Saint Petersburg, Russian Federation.

Recent studies showed that B cells play a major role in the pathogenesis of neurodegeneration in multiple sclerosis (MS). In this study, we aimed to determine the possible link between immunoglobulin free light chains (FLC) and brain atrophy in patients with MS. Ninety-two patients (32 males and 60 females) with MS were included. Read More

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http://dx.doi.org/10.1007/s12026-018-9058-8DOI Listing
December 2018
4 Reads

From the bluetongue vaccination campaigns in sheep to overimmunization and ovine ASIA syndrome.

Immunol Res 2018 Dec;66(6):777-782

Department of Animal Pathology, Veterinary Faculty, University of Zaragoza, 177 Miguel Servet street, 50013, Zaragoza, Spain.

The use of vaccines has proven to be very effective in controlling and eradicating infectious diseases, both in veterinary and human medicine; however, vaccines can be also the source of an array of problems caused by procedures such as overimmunization. Bluetongue, an orbiviral disease that affects ruminants, is best controlled by the use of inactivated vaccines. During the last years of the past decade, these vaccines were applied all over Europe to control the spreading of the disease, a goal that was accomplished; however, at the same time, several adverse effects related to the vaccination were reported. Read More

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http://link.springer.com/10.1007/s12026-018-9059-7
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http://dx.doi.org/10.1007/s12026-018-9059-7DOI Listing
December 2018
11 Reads

The paramount role of cytokines and chemokines in papillary thyroid cancer: a review and experimental results.

Immunol Res 2018 Dec;66(6):710-722

Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.

Our study demonstrates that (C-X-C motif) ligand 9 and 11 (CXCL9, CXCL11) chemokines were absent basally in non-neoplastic thyroid (TFC) and papillary thyroid carcinoma (PTC) cells. Interferon (IFN)γ induced the chemokine secretion in TFC and PTC, while tumor necrosis factor (TNF)α induced it only in PTC. IFNγ+TNFα induced a synergistic chemokines release in PTC, and at a lower level in TFC. Read More

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http://link.springer.com/10.1007/s12026-018-9056-x
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http://dx.doi.org/10.1007/s12026-018-9056-xDOI Listing
December 2018
6 Reads

Correlations between TLR polymorphisms and inflammatory bowel disease: a meta-analysis of 49 case-control studies.

Immunol Res 2019 Feb;67(1):142-150

Department of Immunology and Rheumatology, Gansu Provincial Hospital, No. 204 Donggang West Road, Lanzhou, 730000, Gansu, China.

Recently, the roles of toll-like receptor (TLR) polymorphisms in inflammatory bowel disease (IBD) were intensively explored, with conflicting results. Therefore, we performed this study to better assess the relationship between TLR polymorphisms and the risk of IBD. Eligible studies were searched in PubMed, Medline, Embase, and Web of Science. Read More

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http://link.springer.com/10.1007/s12026-018-9061-0
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http://dx.doi.org/10.1007/s12026-018-9061-0DOI Listing
February 2019
10 Reads

Altered expression of regulatory molecules in the skin of psoriasis.

Immunol Res 2018 Dec;66(6):649-654

Division of Allergy & Clinical Immunology, Bnai-Zion medical Center, Haifa, Israel.

The presence of T regulatory cells (Tregs) is highly required in normal skin in order to maintain immune tolerance to commensal microbes and to prevent the development of immune-mediated inflammation. Psoriasis is a chronic inflammatory skin disease in which effector T cells, namely, Th17 and their relevant pro-inflammatory cytokines are increased in peripheral blood as well as in the inflamed skin. The status of Tregs in psoriatic skin is continuously studied. Read More

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http://link.springer.com/10.1007/s12026-018-9057-9
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http://dx.doi.org/10.1007/s12026-018-9057-9DOI Listing
December 2018
2 Reads

Correction to: Role of microRNAs in host defense against Echinococcus granulosus infection: a preliminary assessment.

Immunol Res 2019 Feb;67(1):98

Unit of Infectious and Tropical Diseases, San Matteo Hospital Foundation, Pavia, Italy.

The published article unfortunately contained mistake. After replacing the image from colored version to black and white, the Fig. 1 caption, unfortunately, was left unupdated. Read More

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http://dx.doi.org/10.1007/s12026-018-9060-1DOI Listing
February 2019
1 Read

Microparticles and autophagy: a new frontier in the understanding of atherosclerosis in rheumatoid arthritis.

Immunol Res 2018 Dec;66(6):655-662

Arthritis Center, Department of Internal Medicine and Medical Specialties, Sapienza University of Rome, Rome, Italy.

Microparticles (MPs) are small membrane vesicles released by many cell types under physiological and pathological conditions. In the last years, these particles were considered as inert cell debris, but recently many studies have demonstrated they could have a role in intercellular communication. Increased levels of MPs have been reported in various pathological conditions including infections, malignancies, and autoimmune diseases, such as rheumatoid arthritis (RA). Read More

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http://dx.doi.org/10.1007/s12026-018-9053-0DOI Listing
December 2018
1 Read

Correction to: Autonomic dysfunction and HPV immunization: an overview.

Immunol Res 2018 Dec;66(6):755

Rheumatology Department, National Institute of Cardiology, Mexico City, Mexico.

In the recently published paper, "Autonomic dysfunction and HPV immunization: an overview", the last name of the lead author is listed incorrectly. The author's name is Svetlana Blitshteyn. Read More

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http://dx.doi.org/10.1007/s12026-018-9055-yDOI Listing
December 2018
2 Reads

Plant and human aquaporins: pathogenesis from gut to brain.

Immunol Res 2019 Feb;67(1):12-20

Immunosciences Lab, Inc, 822 S. Robertson Blvd, Ste 312, Los Angeles, CA, 90035, USA.

Corn, soybean, spinach leaf, and tomato aquaporins have been shown to share homology with human aquaporin-4, which is abundantly expressed by brain astrocytic endfeet. Thus, antibodies formed against the dietary aquaporins may potentially cross-react with brain aquaporin, leading to blood-brain barrier permeability and setting the stage for neuroautoimmunity and neurodegeneration. Here, we review the role of aquaporins in plants and humans in maintaining a healthy organism and mechanisms by which dietary aquaporins may contribute to neurological disorders. Read More

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http://link.springer.com/10.1007/s12026-018-9046-z
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http://dx.doi.org/10.1007/s12026-018-9046-zDOI Listing
February 2019
15 Reads

Routinely utilized in-house assays for infliximab, adalimumab and their anti-drug antibody levels.

Immunol Res 2018 Dec;66(6):726-736

Department of Rheumatology, University Medical Centre Ljubljana, SI-1000, Ljubljana, Slovenia.

By monitoring serum concentrations of infliximab (IFX) and adalimumab (ADL) and levels of their antibodies in patients with inflammatory diseases, clinicians can adjust dose and increase safety and effectiveness of treatment. The aim was to develop and validate in-house enzyme-linked immunosorbent assays (ELISAs) for IFX and ADL, together with anti-IFX and anti-ADL ELISAs for routine detection and further analysis with acid dissociation of immune complexes. Furthermore, the objectives were to compare in-house assays with commercial ELISAs and reporter gene assays (RGAs) and to determine cross-reactivity between original Remicade®/Remsima™ and their antibodies. Read More

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http://dx.doi.org/10.1007/s12026-018-9050-3DOI Listing
December 2018
17 Reads

Intravenous immunoglobulins for rheumatic disorders and thromboembolic events-a case series and review of the literature.

Immunol Res 2018 Dec;66(6):668-674

Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.

To report the temporal association between a series of thromboembolic events and intravenous immunoglobulin infusion in patients with rheumatic diseases, and to review the literature on the subject. The clinical presentation, course, and outcome of thromboembolic events occurring post-immunoglobulin infusion in nine patients is described. A web-based literature review using the PubMed database from 1996 to 2017 was performed, searching for the keywords: thrombosis, thromboembolism, intravenous immunoglobulin, pulmonary embolism, deep vein thrombosis, cerebrovascular event, and acute myocardial infarction. Read More

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http://dx.doi.org/10.1007/s12026-018-9047-yDOI Listing
December 2018
5 Reads

Tuftsin phosphorylcholine-a novel compound harnessing helminths to fight autoimmunity.

Immunol Res 2018 Dec;66(6):637-641

Zabludowicz Center for Autoimmune Diseases, Sheba Medical Center, Tel-Hashomer, affiliated with the Sackler Faculty of Medicine, Tel-Aviv University, Tel Aviv, Israel.

The distinction that in areas where helminthic infections are common, autoimmune diseases are less prevalent, led to the investigation of immune modulatory properties of helminths and their derivatives. Such are phosphorylcholine (PC) moieties which are a component of secreted products of helminths. PC has been broadly studied for its attenuating effects on the human immune system. Read More

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http://link.springer.com/10.1007/s12026-018-9051-2
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http://dx.doi.org/10.1007/s12026-018-9051-2DOI Listing
December 2018
21 Reads

Molecular mimicry, genetic homology, and gene sharing proteomic "molecular fingerprints" using an EBV (Epstein-Barr virus)-derived microarray as a potential diagnostic method in autoimmune disease.

Immunol Res 2018 Dec;66(6):686-695

Rheumatology, Boston University School of Medicine, Arthritis Center, 72 E. Concord Street, E-5, Boston, MA, 02118, USA.

EBV (Epstein-Barr Virus) and other human DNA viruses are associated with autoimmune syndromes in epidemiologic studies. In this work, immunoglobulin G response to EBV-encoded proteins which share regions with human immune response proteins from the human host including ZEBRA (BZLF-1 encoded protein), BALF-2 recombinase expressed primarily during the viral lytic replication cycle, and EBNA-1 (Epstein-Barr Virus Nuclear Antigen) expressed during the viral latency cycle respectively were characterized using a laser-printed micro-array ( PEPperprint.com ). Read More

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http://link.springer.com/10.1007/s12026-018-9045-0
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http://dx.doi.org/10.1007/s12026-018-9045-0DOI Listing
December 2018
18 Reads

FcRγ deficiency improves survival in experimental sepsis by down-regulating TLR4 signaling pathway.

Immunol Res 2019 Feb;67(1):77-83

Department of Oncology, General Hospital of Chinese PLA, 28 Fuxing Road, Beijing, 100853, China.

Fc receptor common γ signaling chain (FcRγ), a common subunit shared by Fc receptors (FcγRI, III, IV, FcαRI, and FcεRI), is an important immune regulator both in innate and adaptive immunity. Previous studies have shown that FcRγ was a potential target of inflammatory diseases, whereas the role of FcRγ in sepsis has been poorly understood. In this study, we found that deficiency of FcRγ resulted in increased survival in lipopolysaccharide (LPS)/D-galactosamine and E. Read More

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http://dx.doi.org/10.1007/s12026-018-9039-yDOI Listing
February 2019
1 Read

Specific features of immune complexes in patients with sarcoidosis and pulmonary tuberculosis.

Immunol Res 2018 Dec;66(6):737-743

FGBU "St. Petersburg Scientific Research Institute of Phthisiopulmonology" of the Ministry of Health of Russia, St. Petersburg, Russia.

Clinical and radiological features of tuberculosis and sarcoidosis are quite overlapping, and therefore, a diagnostic dilemma often persists. There are no commonly accepted criteria for the diagnosis of sarcoidosis due to the lack of data on the etiology of the disease. The exclusion of tuberculosis in every patient with suspected sarcoidosis is a mandatory stage of diagnosis, especially in countries with a high burden of tuberculosis. Read More

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http://link.springer.com/10.1007/s12026-018-9052-1
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http://dx.doi.org/10.1007/s12026-018-9052-1DOI Listing
December 2018
20 Reads

Organochlorine pesticides exposure in female adolescents: potential impact on sexual hormones and interleukin-1 levels.

Immunol Res 2018 Dec;66(6):756-760

Department of Obstetrics and Gynecology, National Research Center of Mother and Child Health, University Medical Center, 32 Turan Avenue, Astana, 010000, Kazakhstan.

The objective of this study was to assess the potential impact of organochlorine pesticides (OCPs) on IL-1 axis in exposed female adolescents through an observational cross-sectional study. The study was conducted in Sary-Agach District (OCPs exposed girls) and Sairam District (OCPs unexposed controls), South Kazakhstan. The study included 524 female adolescents aged 10-17 years (OCPs exposed, n = 253; OCPs unexposed, n = 271). Read More

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http://dx.doi.org/10.1007/s12026-018-9049-9DOI Listing
December 2018
11 Reads

Review of the "X chromosome-nucleolus nexus" hypothesis of autoimmune diseases with an update explaining disruption of the nucleolus.

Authors:
Wesley H Brooks

Immunol Res 2018 Dec;66(6):790-799

Department of Chemistry, University of South Florida, 4202 E. Fowler Ave, CHE205, Tampa, FL, 33620, USA.

The "X chromosome-nucleolus nexus" hypothesis provides a comprehensive explanation of how autoantibodies can develop following cellular stress. The hypothesis connects autoimmune diseases with the impact of environmental factors, such as viruses, through epigenetic disruption. The inactive X chromosome, a major epigenetic structure in the female cell's nucleus, is a key component of the hypothesis. Read More

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http://dx.doi.org/10.1007/s12026-018-9044-1DOI Listing
December 2018
2 Reads

Autoimmunity, inflammation, and dysbiosis mutually govern the transition from the preclinical to the clinical stage of rheumatoid arthritis.

Immunol Res 2018 Dec;66(6):696-709

Human Population Biology Research Unit, Department of Anatomy and Anthropology, Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel.

Currently, it is well recognized that in the natural history of rheumatoid arthritis (RA), an at-risk phase, characterized by the development of autoimmunity, precedes the onset of clinical symptoms in a large proportion of patients. For individuals who later develop seropositive RA, this manifests as autoantibodies directed against proteins that have undergone specific post-translational modifications (PTM). These anti-PTM autoantibodies (APMA) are an important biomarker and risk factor for future RA. Read More

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http://dx.doi.org/10.1007/s12026-018-9048-xDOI Listing
December 2018
4 Reads

Role of microRNAs in host defense against Echinococcus granulosus infection: a preliminary assessment.

Immunol Res 2019 Feb;67(1):93-97

Unit of Infectious and Tropical Diseases, San Matteo Hospital Foundation, Pavia, Italy.

Cystic echinococcosis (CE) is a neglected helminthic zoonosis caused by the larval stage of the tapeworm Echinococcus granulosus s.l. MicroRNAs (miRNAs) are regulators of gene expression that have been linked with the pathogenesis of several human diseases, but little exists in the available literature about miRNAs in CE. Read More

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http://dx.doi.org/10.1007/s12026-018-9041-4DOI Listing
February 2019
6 Reads

Autonomic dysfunction and HPV immunization: an overview.

Immunol Res 2018 Dec;66(6):744-754

Rheumatology Department, National Institute of Cardiology, Mexico City, Mexico.

This article reviews the case series reported from several countries describing patients with suspected severe side effects to the HPV vaccines. The described symptom clusters are remarkably similar and include disabling fatigue, headache, widespread pain, fainting, gastrointestinal dysmotility, limb weakness, memory impairment episodes of altered awareness, and abnormal movements. This constellation of symptoms and signs has been labeled with different diagnoses such as complex regional pain syndrome (CRPS), postural orthostatic tachycardia syndrome (POTS), small fiber neuropathy (SFN), myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), or fibromyalgia. Read More

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http://dx.doi.org/10.1007/s12026-018-9036-1DOI Listing
December 2018
5 Reads

Assessment of immunological profile in ankylosing spondylitis patients following a clinical trial with guluronic acid (G2013), as a new NSAID with immunomodulatory properties.

Immunol Res 2019 Feb;67(1):108-115

Department of Immunology, School of Public Health, Tehran University of Medical Sciences, Box 14155-6446, Tehran, Iran.

The present research aims to study the effects of guluronic acid (G2013) on gene expression levels of the T-bet, GATA3, RORγt, AHR, and FOXP3 transcription factors and on gene expression of their related cytokines following oral administration of this drug in ankylosing spondylitis (AS) patients. In this trial (clinical trial identifier: IRCT2016091813739N4), 14 AS patients and 12 age- and sex-matched healthy individuals were enrolled. The level of transcription factors' gene expression and expression of their related cytokines were measured by quantitative real-time PCR, before and 3 months after G2013 therapy. Read More

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http://link.springer.com/10.1007/s12026-018-9042-3
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http://dx.doi.org/10.1007/s12026-018-9042-3DOI Listing
February 2019
12 Reads
3.100 Impact Factor

Diminazene aceturate (Berenil) downregulates Trypanosoma congolense-induced proinflammatory cytokine production by altering phosphorylation of MAPK and STAT proteins.

Immunol Res 2019 Feb;67(1):84-92

Parasite Vaccines Development Laboratory, Department of Immunology, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, 750 McDermot Avenue, Winnipeg, MB, R3E 0T5, Canada.

Diminazene aceturate (Berenil) is the most commonly used trypanolytic agent in livestock. We previously showed that Berenil downregulates Trypanosoma congolense (T. congolense)-induced cytokine production in macrophages both in vitro and in vivo. Read More

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http://dx.doi.org/10.1007/s12026-018-9040-5DOI Listing
February 2019
16 Reads

Antibody-initiated beneficial and harmful immune responses.

Immunol Res 2018 Dec;66(6):783-789

Department of Surgery, University of Calgary, 2808 Health Sciences Centre, 3330 Hospital Dr. NW, Calgary, Alberta, T2N 4N1, Canada.

A critical function of the immune system is to maintain tolerance to self by corrective immune responses throughout life, including preventing or correcting changes that may interfere with organ function and architectural integrity. These changes have two broad categories, namely (1) exogenous antigen-induced mishaps (e.g. Read More

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http://link.springer.com/10.1007/s12026-018-9037-0
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http://dx.doi.org/10.1007/s12026-018-9037-0DOI Listing
December 2018
13 Reads

Immune reconstitution therapy (IRT) in multiple sclerosis: the rationale.

Immunol Res 2018 Dec;66(6):642-648

MS Center and Unit of Neuroimmunology, Department of Neurology, Hadassah Medical Center, Jerusalem, Israel.

Immunotherapy of multiple sclerosis (MS) and other neuroimmune diseases is rapidly evolving. For the past 25 years, there has been an accelerating inclusion of new immunomodulating drugs. Based on their molecular construction and their basic mechanism of action, immunotherapeutic agents belong to the following categories: (1) cytotoxic drugs, (2) synthetic immunomodulators, (3) monoclonal antibodies, (4) vaccines (T cell vaccines, antigen vaccines), (5) oral tolerizing agents, (6) modalities that act as indirect immunosuppressants (plasmapheresis, intravenous immunoglobulins [IVIG]), and (7) cellular therapies. Read More

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http://link.springer.com/10.1007/s12026-018-9032-5
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http://dx.doi.org/10.1007/s12026-018-9032-5DOI Listing
December 2018
25 Reads

Interleukin 28A.rs12980602 and interleukin 28B.rs8103142 genotypes could be protective against HCV infection among Egyptians.

Immunol Res 2019 Feb;67(1):123-133

The Holding Company for Biological Products and Vaccines (VACSERA), 51 Wizaret El-Zeraa St., Agouza, Giza, 22311, Egypt.

Previous studies showed that interleukin (IL)-28B gene polymorphisms were associated with hepatitis C Virus (HCV) infection and treatment outcomes. We tested whether single-nucleotide polymorphisms (SNPs) in IL-28A and IL-28B are associated with HCV infection among Egyptians with HCV genotype 4 infections. We enrolled 144 chronic HCV patients, 72 spontaneously resolved HCV subjects, and 69 healthy controls. Read More

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http://link.springer.com/10.1007/s12026-018-9035-2
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http://dx.doi.org/10.1007/s12026-018-9035-2DOI Listing
February 2019
12 Reads

Positive correlation between interleukin-1 receptor antagonist gene 86bp VNTR polymorphism and colorectal cancer susceptibility: a case-control study.

Immunol Res 2019 Feb;67(1):151-156

Faculty of Paramedical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Colorectal cancer (CRC) is one of the most common malignancies worldwide. Genetic variations in cytokine genes and their receptors lead to the severity of the disease. The interleukin-1 receptor antagonist (IL1RN) is a cytokine that inhibits interleukin-1 (IL-1) activity by binding to IL-1 receptors. Read More

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http://dx.doi.org/10.1007/s12026-018-9034-3DOI Listing
February 2019
1 Read

1,25-Dihydroxyvitamin D modulates T cell differentiation and impacts on the production of cytokines from Chinese Han patients with early rheumatoid arthritis.

Immunol Res 2019 Feb;67(1):48-57

Department of Medicine, Division of Rheumatology, Shanxi Medical University, the Second Hospital of Shanxi Medical University, 56 South Xinjian Road, Taiyuan, Shanxi Province, China.

To study the effects of 1,25-dihydroxyvitamin D (1,25(OH)D) on the differentiation of T cells and the levels of cytokines in patients with early rheumatoid arthritis (eRA). The levels of Th1, Th2, Th17, and Treg cells were detected with BDFACS Calibur flow cytometer. The expression of IFN-ɤ, TNF-α, IL-2, IL-4, IL-6, IL-10, IL-17, and IL-22 was examined in 54 patients with eRA using a cytometric bead array (CBA). Read More

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http://link.springer.com/10.1007/s12026-018-9033-4
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http://dx.doi.org/10.1007/s12026-018-9033-4DOI Listing
February 2019
5 Reads

The link between schizophrenia and hypothyroidism: a population-based study.

Immunol Res 2018 Dec;66(6):663-667

Department of Medicine 'B', Sheba Medical Center, 5262100, Tel Hashomer, Israel.

Schizophrenia is considered to be of the severe psychiatric disorders characterized by chronic debilitating course marked with frequent relapses and high clinical and financial burden. Aberrations of thyroid hormone levels have been documented in several psychiatric conditions including bipolar disease. The aim of this study is to provide insight into whether an association exists between hypothyroidism and schizophrenia. Read More

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http://link.springer.com/10.1007/s12026-018-9030-7
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http://dx.doi.org/10.1007/s12026-018-9030-7DOI Listing
December 2018
21 Reads

The coexistence of pemphigus and psoriasis: a systematic review and meta-analysis.

Immunol Res 2019 Feb;67(1):134-141

Department of Quality Measurements and Research, Chief Physician's Office, Clalit Health Services, Tel Aviv, Israel.

There is little consensus regarding the association between pemphigus and psoriasis. The aim of the current study is to synthesize existing data on the prevalence of psoriasis in patients with pemphigus and on the association between the two conditions. We performed a systematic review and meta-analysis of observational studies in Medline, Embase, and Web of Science (1900-2018). Read More

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http://dx.doi.org/10.1007/s12026-018-9031-6DOI Listing
February 2019
3 Reads

Significance of the intraindividual variability of HLA IgG antibodies in renal disease patients observed with different beadsets monitored with two different secondary antibodies on a Luminex platform.

Immunol Res 2018 10;66(5):584-604

Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.

The accurate measurement of anti-HLA alloantibodies in transplant candidates is required for determining the degree of sensitization and for the listing of unacceptable antigens for organ allocation. Both the configuration of the HLA molecules coated on the beads and the nature of detection antibodies may impede assessment of the presence and strength of anti-HLA IgG- with the Luminex single-antigen-bead assay. Sera antibodies of the end-stage renal disease patients were compared using LIFECODES (LC) and LABScreen (LS) beadsets monitored with polyclonal-Fab (IgHPolyFab) and monoclonal-IgG (FcMonoIgG) second antibodies. Read More

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http://dx.doi.org/10.1007/s12026-018-9027-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6244961PMC
October 2018
1 Read

Autoimmune vertigo: an update on vestibular disorders associated with autoimmune mechanisms.

Immunol Res 2018 Dec;66(6):675-685

Department of Sense Organs, Sapienza University of Rome, Viale del Policlinico 155, 00100, Rome, Italy.

The role of the immune system in mediating cochleovestibular pathologies has received increasing attention in recent years. Autoimmune vertigo may be an invalidating condition and may worsen the quality of life of affected patients, especially in the cases of delayed diagnosis. Since the etiopathogenesis is still not clear, also the treatment is not yet completely delineated. Read More

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http://dx.doi.org/10.1007/s12026-018-9023-6DOI Listing
December 2018
16 Reads

Leptin receptor is expressed by tissue mast cells.

Immunol Res 2018 10;66(5):557-566

Department of Experimental Immunology, Medical University of Lodz, Lodz, Poland.

Leptin, the adipose tissue-derived product of the obese (ob) gene, is known to function as the hormone of energy expenditure. It has also been established that leptin regulates immune and inflammatory processes. All leptin-induced biological activities depend on binding to the membrane-spanning leptin receptor (Ob-R), belonging to the class I cytokine receptor family. Read More

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http://dx.doi.org/10.1007/s12026-018-9029-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6244893PMC
October 2018
2 Reads

Long-term persistence of anti-rods and rings antibodies in patients with chronic hepatitis C after antiviral treatment.

Immunol Res 2018 10;66(5):605-610

Department of Gastroenterology and Hepatology, Hospital das Clínicas, Universidade Federal de Pernambuco, Av. Professor Moraes Rego, 1235, Recife, PE, 50670-901, Brazil.

Anti-rods and rings (anti-RR) antibodies are related to hepatitis C virus (HCV) in patients treated with pegylated interferon (PEG-IFN) and ribavirin (RBV). Only RBV induces rods/rings structures in vitro; but in vivo, the antibody appearance is related to the combination of these drugs, because data about patients using just one of these drugs alone is missing. Some studies suggest disappearance of these antibodies over time. Read More

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http://dx.doi.org/10.1007/s12026-018-9026-3DOI Listing
October 2018
5 Reads

Biological predictors shared by dementia and bullous pemphigoid patients point out a cross-antigenicity between BP180/BP230 brain and skin isoforms.

Immunol Res 2018 10;66(5):567-576

Division of Dermatology, Department of Medical Clinics, Ribeirão Preto Medical School, University of São Paulo, Av. Bandeirantes, 3900, Ribeirao Preto, São Paulo, 14049-900, Brazil.

Bullous pemphigoid (BP) following dementia diagnosis has been reported in the elderly. Skin and brain tissues express BP180 and BP230 isoforms. Dementia has been associated with rs6265 (Val66Met) polymorphism of the brain-derived neurotrophic factor (BDNF) gene and low serum BDNF. Read More

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http://dx.doi.org/10.1007/s12026-018-9028-1DOI Listing
October 2018
4 Reads

What is the best time to assess the antiphospholipid antibodies (aPL) profile to better predict the obstetric outcome in antiphospholipid syndrome (APS) patients?

Immunol Res 2018 10;66(5):577-583

Hemostasis and Thrombosis Laboratory, Hospital of Infectious Diseases "Dr. Francisco J. Muñiz", Uspallata 2272, C1282AEN, City of Buenos Aires, Argentina.

Serological risk factors are the most important determinant in predicting unsuccessful pregnancy in obstetric antiphospholipid antibodies syndrome (OAPS) despite conventional treatment. It is not clear if changes in the profile of antiphospholipid antibodies (aPL) during pregnancy modify the risk associated with a poor response to conventional treatment. The aim of our study was to compare the value of a serological tag for aPL obtained before and during the first trimester of pregnancy to predict the response to conventional treatment. Read More

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http://dx.doi.org/10.1007/s12026-018-9024-5DOI Listing
October 2018
4 Reads

Sulfuretin alleviates atopic dermatitis-like symptoms in mice via suppressing Th2 cell activity.

Immunol Res 2018 10;66(5):611-619

Department of Dermatology, Wuxi No.2 People's Hospital, Wuxi, 214002, Jiangsu, China.

Atopic dermatitis (AD) is a chronic skin inflammatory disease characterized by uncontrolled Th2 cells response to environmental allergens. Long-term topical application of corticosteroids for treating AD may induce severe side effects. Sulfuretin is a major flavonoid found in Rhus verniciflua and carries antioxidant and anti-inflammatory properties. Read More

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http://dx.doi.org/10.1007/s12026-018-9025-4DOI Listing
October 2018
2 Reads

The role of T regulatory cell-associated markers in monitoring tuberculosis treatment completion and failure.

Immunol Res 2018 10;66(5):620-631

Department of Immunology, National JALMA Institute for Leprosy and Other Mycobacterial Diseases, Agra, India.

Monitoring tuberculosis (TB) treatment success is crucial for clinical decision-making. The only available tool in this regard is sputum microscopy, but it has demerits. Moreover, in case of smear negatives and extrapulmonary TB, an efficient tool is still sought for. Read More

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http://dx.doi.org/10.1007/s12026-018-9022-7DOI Listing
October 2018
13 Reads