328,419 results match your criteria Immunologic Research [Journal]


Fruit for thought: anaphylaxis to fruit pectin in foods.

J Allergy Clin Immunol Pract 2018 Dec 12. Epub 2018 Dec 12.

Division of Allergy & Immunology, Children's Hospital of Philadelphia, Philadelphia, PA; Perelman School of Medicine at The University of Pennsylvania, Philadelphia, PA.

Clinical Implications: Pectin is a structural heteropolysaccharide previously associated with occupational asthma and only rare accounts of allergy. Few case reports, however, suggest that pectin may contribute to atypical or idiopathic food reactions, particularly in patients with IgE-mediated allergy to tree nuts. Read More

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December 2018

Clinical relevance of enteropathogen co-infections in preschool children - a population-based repeated cross-sectional study.

Clin Microbiol Infect 2018 Dec 12. Epub 2018 Dec 12.

Center for Infectious Disease Control, National Institute for Public Health and the Environment (RIVM), Bilthoven, the Netherlands; Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, the Netherlands.

Objectives: This study aimed to (i) determine risk factors for enteropathogen co-infections, (ii) determine whether enteropathogen co-infections influence gastroenteritis risk, and (iii) determine whether enteropathogen co-infection occurred randomly in preschool children.

Methods: A monthly-repeated cross-sectional survey in Dutch children aged 0-48 months was conducted during October 2012-October 2014. 981 stool samples were collected along with questionnaires collecting data on gastrointestinal symptoms and potential risk factors. Read More

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December 2018

Comparative risk of venous thromboembolism with tofacitinib versus tumor necrosis factor inhibitors: A cohort study of rheumatoid arthritis patients.

Arthritis Rheumatol 2018 Dec 15. Epub 2018 Dec 15.

Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women's Hospital & Harvard Medical School, Boston, MA, USA.

Objective: To evaluate the risk of venous thromboembolism (VTE) with tofacitinib versus tumor necrosis factor (TNF)-inhibitors in rheumatoid arthritis (RA) patients.

Methods: RA patients initiating tofacitinib or a TNF inhibitor without use of any biologic or tofacitinib any time prior were identified from Truven MarketScan (2012-2016) or Medicare claims (parts A, B, and D, 2012-2015) and followed until treatment discontinuation, treatment switch, insurance disenrollment, or administrative censoring. The outcome of VTE was identified using inpatient claims for pulmonary embolism or deep vein thrombosis. Read More

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December 2018

Skin tape stripping: which layers of the epidermis are removed?

Contact Dermatitis 2018 Dec 15. Epub 2018 Dec 15.

The National Allergy Research Centre, Department of Dermatology and Allergy, Copenhagen University Hospital Herlev-Gentofte, Hellerup, Denmark.

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December 2018
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Progressive Multifocal Leukoencephalopathy in Primary Immunodeficiencies.

J Clin Immunol 2018 Dec 14. Epub 2018 Dec 14.

Department of Haematology, Assistance Publique-Hôpitaux de Paris, Hôpital Necker-Enfants Malades, France et Université Paris Descartes, 149 rue de Sèvres, 75015, Paris, France.

Purpose: Progressive multifocal leukoencephalopathy (PML) is a rare but severe demyelinating disease caused by the polyomavirus JC (JCV) in immunocompromised patients. We report a series of patients with primary immune deficiencies (PIDs) who developed PML.

Methods: Retrospective observational study including PID patients with PML. Read More

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December 2018

Author Correction: A human monoclonal antibody prevents malaria infection by targeting a new site of vulnerability on the parasite.

Nat Med 2018 Dec 14. Epub 2018 Dec 14.

Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.

In the version of this article originally published, data were incorrectly ascribed to monoclonal antibody CIS34 because of a labeling error. The data were generated with monoclonal antibody CIS04. Full details can be found in the correction notice. Read More

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December 2018

Genetic association of non-MHC region with ankylosing spondylitis in a Chinese population.

Ann Rheum Dis 2018 Dec 14. Epub 2018 Dec 14.

State Key Laboratory of Genetic Engineering, Collaborative Innovation Center for Genetics and Development, School of Life Sciences, Fudan University, Shanghai, China

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December 2018

Inference of the HIV-1 VRC01 Antibody Lineage Unmutated Common Ancestor Reveals Alternative Pathways to Overcome a Key Glycan Barrier.

Immunity 2018 Dec 5. Epub 2018 Dec 5.

Duke Human Vaccine Institute, Duke University, Durham, NC, USA; Department of Medicine, Duke University, Durham, NC, USA; Department of Immunology, Duke University, Durham, NC, USA. Electronic address:

Elicitation of VRC01-class broadly neutralizing antibodies (bnAbs) is an appealing approach for a preventative HIV-1 vaccine. Despite extensive investigations, strategies to induce VRC01-class bnAbs and overcome the barrier posed by the envelope N276 glycan have not been successful. Here, we inferred a high-probability unmutated common ancestor (UCA) of the VRC01 lineage and reconstructed the stages of lineage maturation. Read More

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December 2018

Supercritical Fluid Extract Exhibits Necroptotic Effects and Anti-Metastatic Activity on Lung Cancer Cells.

Molecules 2018 Dec 13;23(12). Epub 2018 Dec 13.

Department of Nutrition, I-Shou University, Kaohsiung 82445, Taiwan.

(BS) has long been used as an analgesic, wound-healing and anti-inflammatory medicinal plant. The aqueous extract of its bark has been demonstrated to have anti-cancer activity. This study investigated the anti-proliferative and anti-metastatic effects of BS supercritical fluid extract (BSE) on the A549 and H661 lung cancer cell lines. Read More

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December 2018

Amelioration of clinical symptoms of patients with refractory rheumatoid arthritis following treatment with autologous bone marrow-derived mesenchymal stem cells: A successful clinical trial in Iran.

Biomed Pharmacother 2019 Jan 26;109:1834-1840. Epub 2018 Nov 26.

Immunology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran; Allergy Research Center, Mashhad University of Medical Sciences, Mashhad, Iran. Electronic address:

Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune arthropathy characterized by synovial hyperplasia leading to functional impairment. Although the exact cause of RA is unknown, there is evidence suggesting the role of T cell subtypes in the pathogenesis of RA. Conventional therapy in some RA patients is associated with mild or severe side effects, and resistance of some patients has been reported to these types of therapy. Read More

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January 2019

The Asthma Controller Step-down Yardstick.

Ann Allergy Asthma Immunol 2018 Dec 11. Epub 2018 Dec 11.

Kaiser Permanente Southern California Region, Department of Allergy and Research and Evaluation, San Diego and Pasadena, CA.

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December 2018
2 Reads

Development of a Health-Related Quality of Life (QoL) instrument for Patients with Hereditary Angioedema (HAE) living in the United States.

J Allergy Clin Immunol Pract 2018 Dec 11. Epub 2018 Dec 11.

Division of Rheumatology, Allergy and Immunology, Department of Medicine, University of California San Diego, La Jolla, CA.

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December 2018

Interferon-gamma production in Lyme arthritis synovial tissue promotes differentiation of fibroblast-like synoviocytes into immune effector cells.

Cell Microbiol 2018 Dec 14:e12992. Epub 2018 Dec 14.

Center for Immunology & Inflammatory Diseases, Division of Rheumatology, Allergy, & Immunology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.

Lyme arthritis (LA), a late disease manifestation of Borrelia burgdorferi infection, usually resolves with antibiotic therapy. However, some patients develop proliferative synovitis lasting months to several years after spirochetal killing, called post-infectious LA. In this study, we phenotyped hematopoietic and stromal cell populations in the synovial lesion ex vivo and used these findings to generate an in vitro model of LA using patient-derived fibroblast-like synoviocytes (FLS). Read More

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December 2018

[Effects of budesonide aerosol inhalation on the immunological functions of peripheral dendritic cells in patients with allergic rhinitis].

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2018 Sep;32(18):1391-1395

Department of Otolaryngology Head and Neck Surgery, the First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710061, China.

To investigate the immunologic functional changes of peripheral dendritic cells (DC) in patients with allergic rhinitis (AR) during the treatment by budesonide aerosol inhalation.25 patients with moderate to severe persistent AR were concluded in current study, and they were given budesonide aerosol inhalation for 8 weeks. AR related nasal symptom scores and indices, peripheral DC counts and percentages as well as their activation before and 4 weeks, 8 weeks after treatment were determined. Read More

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September 2018

Preoperative serum albumin as a predictor of complications following total hip replacement in patients with rheumatoid arthritis.

Acta Ortop Mex 2018 Jul-Aug;32(4):193-197

Trauma and Orthopaedic Surgery Hospitals. UMAE «Dr. Victorio de la Fuente Narváez», Mexico City.

Background: Rheumatoid arthritis is a chronic inflammatory disease characterized by polyarthritis with progressive articular wear, immunologic abnormalities and increasing physical limitation. Surgical correction with hip replacement comes as a successful solution for patients with advanced articular destruction. Following intervention, surgical site infection (SSI), venous thromboembolism, sepsis, renal and major cardiovascular complications are among the most cited in the literature. Read More

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December 2018

The Burden of Caring for a Child or Adolescent With Pediatric Acute-Onset Neuropsychiatric Syndrome (PANS): An Observational Longitudinal Study.

J Clin Psychiatry 2018 Dec 11;80(1). Epub 2018 Dec 11.

Pediatric Divisions of Child & Adolescent Psychiatry, Stanford University School of Medicine, Palo Alto, California, USA.

Objective: To describe the longitudinal association between disease severity, time established in clinical treatment, and caregiver burden in a community-based patient population diagnosed with pediatric acute-onset neuropsychiatric syndrome (PANS).

Methods: The study included an observational longitudinal cohort design, with Caregiver Burden Inventories (CBIs) collected between April 2013 and November 2016 at the Stanford PANS multidisciplinary clinic. Inclusion criteria for this study were as follows: pediatric patients meeting strict PANS/pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections (PANDAS) diagnostic criteria (n = 187), having a caregiver fill out at least 1 complete CBI during a disease flare (n = 114); and having family who lives locally (n = 97). Read More

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December 2018

Optimizing the Clinical Utility of Sirolimus-Based Immunosuppression for Kidney Transplantation.

Clin Transplant 2018 Dec 13:e13464. Epub 2018 Dec 13.

Clínica Universitaria Colombia, Fundacion Universitária de Ciencias de la Salud, Bogotá, Colombia.

While calcineurin inhibitors (CNIs) are effective for preventing acute rejection in kidney transplant recipients, long-term use may cause chronic kidney injury and is associated with increased risks of cardiovascular events, cancer, and infection-associated death. Immunosuppression strategies are needed to balance risks of acute and subclinical rejection with long-term benefits of improved kidney function. Sirolimus, an inhibitor of mammalian target of rapamycin, is used for immunosuppression in kidney transplantation. Read More

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December 2018

Immunologic modification in mono- and poly-sensitized patients after sublingual immunotherapy.

Laryngoscope 2018 Dec 13. Epub 2018 Dec 13.

Department of Otorhinolaryngology-Head and Neck Surgery, Seoul National University College of Medicine, Seoul, Korea.

Objectives/hypothesis: To compare immunologic modification and treatment outcomes after 2 years of sublingual immunotherapy (SLIT) with house dust mite extracts (HDM) between monosensitized and polysensitized patients with allergic rhinitis.

Study Design: Retrospective cohort study.

Methods: Among the patients who were prospectively enrolled in the SLIT cohort study, patients with allergic rhinitis who were sensitized to HDM and treated with SLIT for at least 2 years were studied. Read More

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December 2018

Epidemiological association between multiple chemical sensitivity and birth by caesarean section: a nationwide case-control study.

Environ Health 2018 Dec 14;17(1):89. Epub 2018 Dec 14.

Clinical Research Center for Allergy and Rheumatology, National Hospital Organization Sagamihara National Hospital, 18-1 Sakuradai, Minami-ku, Sagamihara, Kanagawa, 252-0392, Japan.

Introduction: Multiple chemical sensitivity (MCS) is characterized by recurrent nonspecific symptoms that are attributed to exposure to trace levels of environmental agents. Although the clinical symptoms of MCS have been described in several studies, the risk factors for this condition remain unclear. Our aim was to clarify the risk factors for MCS and the association between MCS and birth by caesarean section. Read More

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December 2018

Ultrasound shear wave elastography effectively predicts integrity of ventral hernia repair using acellular dermal matrix augmented with platelet-rich plasma (PRP).

Surg Endosc 2018 Dec 13. Epub 2018 Dec 13.

Department of Electrical and Computer Engineering, Texas A&M University, 309D Wisenbaker Engineering Research Center, College Station, TX, 77843-3128, USA.

Background: Complications of ventral hernia repair (VHR) may be investigated by computed tomography or ultrasound (US) but neither modality gives a quantifiable metric of repair quality short of identifying hernia recurrence. Platelet-rich plasma (PRP), a growth factor-rich autologous blood product, has been shown to improve incorporation of native tissue with bioprosthetics. In this study, we investigate the effect of PRP on the incorporation and mechanical integrity of a non-crosslinked porcine acellular dermal matrix (pADM) in a rodent model of VHR and the correlative ability of ultrasound shear wave elastography (US-SWE) to assess repair quality. Read More

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December 2018
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Imaging of Bronchial Pathology in Antibody Deficiency: Data from the European Chest CT Group.

J Clin Immunol 2018 Dec 13. Epub 2018 Dec 13.

Paediatric Immunology Unit, Department of Paediatric Pulmonology, Allergology and Neonatology, Hanover Medical School, Carl-Neuberg Str. 1, 30625, Hannover, Germany.

Studies of chest computed tomography (CT) in patients with primary antibody deficiency syndromes (ADS) suggest a broad range of bronchial pathology. However, there are as yet no multicentre studies to assess the variety of bronchial pathology in this patient group. One of the underlying reasons is the lack of a consensus methodology, a prerequisite to jointly document chest CT findings. Read More

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December 2018
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Interferon-α-induced retinopathy in chronic hepatitis C treatment: summary, considerations, and recommendations.

Graefes Arch Clin Exp Ophthalmol 2018 Dec 13. Epub 2018 Dec 13.

Department of Ophthalmology and Vision Sciences, Princess Margaret Hospital/University Health Network, University of Toronto, 610 University Avenue, Toronto, ON, M5G 2M9, Canada.

Interferons are cytokines that regulate the host's response to viral infection, particularly in the setting of the immunologic response to the hepatitis C virus (HCV). While the virus has the ability to evade the host's innate and specific immunity, exogenous interferon-α with combined ribavirin, treatments have been found to achieve a significant sustained viral response in subgroups of patients with chronic HCV. One of the major side effects of interferon-α is an ocular retinopathy characterized by flame-shaped hemorrhages and cotton wool spots visualized on funduscopic examination. Read More

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December 2018

Quantification of Infectious Sendai Virus Using Plaque Assay.

Bio Protoc 2018 Nov;8(21)

Department of Pathology and Laboratory Medicine, Cedars-Sinai Medical Center, Los Angeles, USA.

Sendai virus (SeV) is an enveloped, single-stranded RNA virus of the family . SeV is a useful tool to study its infectious pathomechanism in immunology and the pathomechanism of a murine model of IgA nephropathy. Virus quantification is essential not only to determine the original viral titers for an appropriate application, but also to measure the viral titers in samples from the harvests from experiments. Read More

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November 2018
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Virus-like particles (VLP) in prophylaxis and immunotherapy of allergic diseases.

Allergo J Int 2018 9;27(8):245-255. Epub 2018 Jul 9.

9Jenner Institute, University of Oxford, Oxford, UK.

Background: Apart from active allergen avoidance, immunotherapy is regarded as the most effective form of treatment available for type I allergies. Such treatments involve the administration of allergen preparations in various forms and by various routes. Virus-like particles (VLPs) offer a very effective platform for immunization with the allergen and are characterized by high immunogenicity, low allergenicity and high clinical efficacy. Read More

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Not All Rashes Are Allergic: Keratoderma Blennorrhagicum-Like Rash Masquerading as Contact Dermatitis.

Allergy Rhinol (Providence) 2018 Jan-Dec;9:2152656718811566. Epub 2018 Dec 4.

Division of Allergy and Clinical Immunology, University of Colorado Anschutz Medical Campus, Aurora, Colorado.

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December 2018

Human umbilical cord-derived mesenchymal stem cells ameliorate the enteropathy of food allergies in mice.

Exp Ther Med 2018 Dec 19;16(6):4445-4456. Epub 2018 Sep 19.

Department of Immunology, School of Medicine, Jiangsu University, Zhenjiang, Jiangsu 212013, P.R. China.

Food allergy prevalence has steadily increased worldwide over the past decades and immunotherapeutic treatment strategies are gaining attention. Human umbilical cord-derived mesenchymal stem cells (hUC-MSCs) exhibit similar immune regulatory properties to bone marrow-derived MSCs. hUC-MCSs can be prepared with fewer ethical constraints and are potential candidates for allergic disorder therapies. Read More

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December 2018
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Bacterial blood stream infections (BSIs), particularly post-engraftment BSIs, are associated with increased mortality after allogeneic hematopoietic cell transplantation.

Bone Marrow Transplant 2018 Dec 13. Epub 2018 Dec 13.

Division of Hematology/Oncology, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.

We analyzed CIBMTR data to evaluate the incidence of non-relapse mortality (NRM) and association with overall survival (OS) for bacterial blood stream infections (BSIs) occurring within 100 days of alloHCT in 2 different phases: pre-/peri-engraftment (BSI very early phase, BSI-VEP) and BSI post-engraftment (BSI occurring between 2 weeks after engraftment and day 100, late early phase, BSI-LEP). Of the 7128 alloHCT patients, 2656 (37%) had ≥1 BSI by day 100. BSI-VEP, BSI-LEP, and BSI-Both constituted 56% (n = 1492), 31% (n = 824), and 13% (n = 340) of total BSI, respectively. Read More

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December 2018

Host-specific expression of Ixodes scapularis salivary genes.

Ticks Tick Borne Dis 2018 Dec 3. Epub 2018 Dec 3.

Section of Infectious Diseases, New Haven, CT, 06520, USA; Howard Hughes Medical Institute, Chevy Chase, Maryland, 20815, USA.

Ixodes scapularis vectors several pathogens including Borrelia burgdorferi, the agent of Lyme disease. Nymphal and larval stages, and the pathogens transmitted by I. scapularis are maintained in a zoonotic cycle involving rodent reservoir hosts, predominantly Peromyscus leucopus. Read More

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December 2018

Development and Modification of an Outcome Measure to Follow Symptoms of Children with Sinusitis.

J Pediatr 2018 Dec 10. Epub 2018 Dec 10.

Division of General Academic Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, PA.

Objective: To develop a parent-reported Pediatric Rhinosinusitis Symptom Scale (PRSS) that could be used to monitor symptoms of young children with acute sinusitis in response to therapy.

Study Design: We developed an 8-item symptom severity scale and evaluated its internal reliability, construct validity, and responsiveness in children 2-12 years of age with acute sinusitis. Parents of 258 children with acute sinusitis completed the PRSS at the time of diagnosis, as a diary at home, and at the follow-up visit at days 10-12. Read More

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December 2018
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Modulation of Innate Immune Responses by the Influenza A NS1 and PA-X Proteins.

Viruses 2018 Dec 12;10(12). Epub 2018 Dec 12.

Department of Microbiology and Immunology, University of Rochester, Rochester, New York, NY 14642, USA.

Influenza A viruses (IAV) can infect a broad range of animal hosts, including humans. In humans, IAV causes seasonal annual epidemics and occasional pandemics, representing a serious public health and economic problem, which is most effectively prevented through vaccination. The defense mechanisms that the host innate immune system provides restrict IAV replication and infection. Read More

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December 2018
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Pathogen at the Gates: Human Cytomegalovirus Entry and Cell Tropism.

Viruses 2018 Dec 11;10(12). Epub 2018 Dec 11.

Department of Microbiology and Immunology, Louisiana State University Health Sciences Center, Shreveport, LA 71103, USA.

The past few years have brought substantial progress toward understanding how human cytomegalovirus (HCMV) enters the remarkably wide spectrum of cell types and tissues that it infects. Neuropilin-2 and platelet-derived growth factor receptor alpha (PDGFRα) were identified as receptors, respectively, for the trimeric and pentameric glycoprotein H/glycoprotein L (gH/gL) complexes that in large part govern HCMV cell tropism, while CD90 and CD147 were also found to play roles during entry. X-ray crystal structures for the proximal viral fusogen, glycoprotein B (gB), and for the pentameric gH/gL complex (pentamer) have been solved. Read More

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December 2018

Eosinophilia and Kidney Disease: More than Just an Incidental Finding?

J Clin Med 2018 Dec 8;7(12). Epub 2018 Dec 8.

Department of Internal Medicine IV (Nephrology and Hypertension), Medical University Innsbruck, 6020 Innsbruck, Austria.

Peripheral blood eosinophilia (PBE), defined as 500 eosinophils or above per microliter (µL) blood, is a condition that is not uncommon but often neglected in the management of patients with chronic kidney disease (CKD), acute kidney injury (AKI), or patients on renal replacement therapy (RRT). The nature of PBE in the context of kidney diseases is predominantly secondary or reactive and has to be distinguished from primary eosinophilic disorders. Nonetheless, the finding of persistent PBE can be a useful clue for the differential diagnosis of underdiagnosed entities and overlapping syndromes, such as eosinophilic granulomatosis with polyangiitis (EGPA), IgG4-related disease (IgG4-RD), acute interstitial nephritis (AIN), or the hypereosinophilic syndrome (HES). Read More

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December 2018

Subclinical Infection of Macaques and Baboons with A Baboon Simarterivirus.

Viruses 2018 Dec 10;10(12). Epub 2018 Dec 10.

Department of Pathology and Laboratory Medicine, University of Wisconsin⁻Madison, Madison, WI 53711, USA.

Simarteriviruses (: ) are commonly found at high titers in the blood of African monkeys but do not cause overt disease in these hosts. In contrast, simarteriviruses cause severe disease in Asian macaques upon accidental or experimental transmission. Here, we sought to better understand the host-dependent drivers of simarterivirus pathogenesis by infecting olive baboons (n = 4) and rhesus monkeys (n = 4) with the simarterivirus Southwest baboon virus 1 (SWBV-1). Read More

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December 2018

The Multifaceted Roles of Autophagy in Flavivirus-Host Interactions.

Authors:
Po-Yuan Ke

Int J Mol Sci 2018 Dec 7;19(12). Epub 2018 Dec 7.

Department of Biochemistry & Molecular Biology and Graduate Institute of Biomedical Sciences, College of Medicine, Chang Gung University, Taoyuan 33302, Taiwan.

Autophagy is an evolutionarily conserved cellular process in which intracellular components are eliminated via lysosomal degradation to supply nutrients for organelle biogenesis and metabolic homeostasis. Flavivirus infections underlie multiple human diseases and thus exert an immense burden on public health worldwide. Mounting evidence indicates that host autophagy is subverted to modulate the life cycles of flaviviruses, such as hepatitis C virus, dengue virus, Japanese encephalitis virus, West Nile virus and Zika virus. Read More

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December 2018
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Long-term tumor-free survival in a metastatic pancreatic carcinoma patient with FOLFIRINOX/Mitomycin, high-dose, fever inducing Viscum album extracts and subsequent R0 resection: A case report.

Medicine (Baltimore) 2018 Dec;97(49):e13243

Institute for Applied Epistemology and Medical Methodology (IFAEMM) at the University of Witten/Herdecke, Freiburg i. Brsg., Germany.

Rationale: Metastatic pancreatic cancer has a dismal prognosis. Many patients seek integrative care as an add-on to their conventional cancer treatment. Viscum album extracts (VAE)-widely used as an adjunct to cancer treatment-have cytotoxic, apoptogenic, and immune stimulatory properties. Read More

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December 2018
3 Reads

Expression Density of Receptors as a Potent Regulator of Cell Function and Property in Health and Pathology.

Int Arch Allergy Immunol 2018 Dec 13:1-10. Epub 2018 Dec 13.

Federal State Budgetary Scientific Institution "Research Institute of Fundamental and Clinical Immunology" (RIFCI), Novosibirsk, Russian Federation.

The expression of cytokine receptors has a crucial role in many cellular processes. Recent studies reported that changes of receptor expression could control the action of mediators on target cells. The initiation of different signaling pathways and, therefore, specific effects on cells, depends on certain components forming the cytokine-receptor complex. Read More

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December 2018

Characterization of Patients with Ibuprofen Hypersensitivity.

Int Arch Allergy Immunol 2018 Dec 13:1-5. Epub 2018 Dec 13.

Division of Allergy and Clinical Immunology, St. Michael's Hospital, University of Toronto, Toronto, Ontario,

Background: Ibuprofen is the most frequently used over-the-counter nonsteroidal anti-inflammatory drug (NSAID) in North America. While it has been commonly implicated in drug-induced hypersensitivity reactions, there is limited literature specifically on ibuprofen hypersensitivity.

Objectives: To characterize the demographics and clinical course of hypersensitivity reactions in a cohort of patients with ibuprofen allergy. Read More

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December 2018

Human norovirus propagation in human induced pluripotent stem cell-derived intestinal epithelial cells.

Cell Mol Gastroenterol Hepatol 2018 Dec 10. Epub 2018 Dec 10.

Division of Mucosal Vaccine, Research and Development Center for Mucosal Vaccines, The Institute of Medical Science, The University of Tokyo, Tokyo 108-8639 Japan; Division of Mucosal Barriology, Research and Development Center for Mucosal Vaccines, The Institute of Medical Science, The University of Tokyo, Tokyo 108-8639 Japan; Division of Mucosal Immunology, IMSUT Distinguished Professor Unit, The Institute of Medical Science, The University of Tokyo, Tokyo 108-8639 Japan; Department of Immunology, Graduate School of Medicine, Chiba University, Chiba, Japan; Department of Medicine, School of Medicine and CU-UCSD Center for Mucosal Immunology, Allergy and Vaccine, University of California, San Diego, CA, USA.

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December 2018

Siglec-8 in eosinophilic disorders: receptor expression and targeting using chimeric antibodies.

J Allergy Clin Immunol 2018 Dec 10. Epub 2018 Dec 10.

Human Eosinophil Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, MD. Electronic address:

Background: Sialic acid-binding immunoglobulin-like lectin (Siglec)-8 is selectively expressed on eosinophils, mast cells and basophils, and, when engaged on eosinophils, can cause cell death.

Objective: To characterize surface and soluble Siglec-8 levels in normal (ND) and eosinophilic (EO) subjects and assess the efficacy of anti-Siglec-8 antibodies in inducing eosinophil cell death in vitro.

Methods: Eosinophil expression of Siglec-8 was assessed using flow cytometry and quantitative PCR. Read More

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December 2018

RIGHT VENTRICULAR FUNCTIONAL RESERVE IN EARLY STAGE IDIOPATHIC PULMONARY FIBROSIS: AN EXERCISE TWO DIMENSIONAL SPECKLE TRACKING DOPPLER ECHOCARDIOGRAPHY STUDY On Behalf of The RIGHT Heart International NETwork (RIGHT-NET) Investigators.

Chest 2018 Dec 10. Epub 2018 Dec 10.

'Cava de' Tirreni and Amalfi Coast' Hospital, Division of Cardiology, Heart Department, University Hospital, Salerno, Italy.

Background: The most important determinant of long term survival in idiopathic pulmonary fibrosis (IPF) patients is the adaptation of the right ventricle (RV) to the increased pulmonary vascular resistance. Our aim was to explore RV contractile reserve during stress echocardiography (SE) in early stage IPF.

Methods: 50 early stage IPF patients and 50 healthy controls underwent rest and SE, including RV 2-dimensional Speckle Tracking Echocardiography (2DSTE). Read More

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December 2018

Exploring the Gut Fungi-Lung Allergy Axis.

Cell Host Microbe 2018 Dec;24(6):755-757

Faculty of Medicine, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8575, Japan.

Gut fungal dysbiosis exacerbates colitis and lung allergy. In recent studies published in Science (Leonardi et al., 2018) and Cell Host & Microbe (Li et al. Read More

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December 2018

The Association Between Human Leukocyte Antigens and ITP, TTP, and HIT.

J Pediatr Hematol Oncol 2018 Dec 12. Epub 2018 Dec 12.

Thalassemia and Hemoglobinopathy Research Center, Research Institute of Health.

Background: Autoimmune thrombocytopenia in immune thrombocytopenic purpura (ITP), thrombotic thrombocytopenic purpura (TTP), and heparin-induced thrombocytopenia (HIT) is associated with immunologic degradation of platelets and reduced platelet counts in patients, leading to bleeding risk in patients. Considering the role of human leukocyte antigens (HLA) in the development of immune response, in this review, we examine the relationship between HLA and pathogenesis of the above-mentioned diseases.

Methods: Relevant English-language literature was searched and retrieved from Google Scholar search engine and PubMed database (1979 to 2018). Read More

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December 2018

Soluble Tumor Necrosis Factor (TNF)-Like Weak Inducer of Apoptosis (Tweak) Independently Predicts Subclinical Atherosclerosis in Behcet's Disease.

Acta Medica (Hradec Kralove) 2018 ;61(3):86-92

Division of Rheumatology, Department of Internal Medicine, Malatya State Hospital, Malatya, Turkey.

Background: Vasculopathy is a major cause of mortality and morbidity in Behcet's Disease (BD). Subclinical atherosclerosis can even be detected in the early stage of BD. Soluble tumor necrosis factor-like (TNF) weak inducer of apoptosis (TWEAK) is known as a good marker of the inflammation in vascular tree. Read More

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January 2018
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Drug Discovery for Kinetoplastid Diseases: Future Directions.

ACS Infect Dis 2018 Dec 13. Epub 2018 Dec 13.

Novartis Institute for Tropical Diseases (NITD) , 5300 Chiron Way , Emeryville , California 94608 , United States.

Kinetoplastid parasites have caused human disease for millennia. Significant achievements have been made toward developing new treatments for leishmaniasis (particularly on the Indian subcontinent) and for human African trypanosomiasis (HAT). Moreover, the sustained decrease in the incidence of HAT has made the prospect of elimination a tantalizing reality. Read More

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December 2018

Hematopoietic Stem Cell Transplantation in Patients with Heterozygous STAT1 Gain-of-Function Mutation.

J Clin Immunol 2018 Dec 13. Epub 2018 Dec 13.

Division of Pediatric Allergy/Immunology, Marmara University, Fevzi Çakmak Mah. No: 41, Pendik, Istanbul, Turkey.

Purpose: Human signal transducer and activator of transcription 1 (STAT1) gain-of-function (GOF) mutations present with a broad range of manifestations ranging from chronic mucocutaneous candidiasis and autoimmunity to combined immunodeficiency (CID). So far, there is very limited experience with hematopoietic stem cell transplantation (HSCT) as a therapeutic modality in this disorder. Here, we describe two patients with heterozygous STAT1 GOF mutations mimicking CID who were treated with HSCT. Read More

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December 2018

NMR resonance assignments of the pathogenesis-related peach allergen Pru p 1.0101.

Biomol NMR Assign 2018 Dec 12. Epub 2018 Dec 12.

Institute of Organic Chemistry and Center for Molecular Biosciences Innsbruck (CMBI), University of Innsbruck, Innrain 80/82, 6020, Innsbruck, Austria.

In Europe, Northern America, and China a large number of individuals are suffering from peach (Prunus persica) allergy caused by the protein Pru p 1. Immunologic reactions against this 17.5 kDa protein result from initial sensitization to the birch (Betula verrucosa) pollen allergen Bet v 1 and subsequent immunologic cross-reactivity of Bet v 1 specific antibodies. Read More

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December 2018

A Rare Instance of Simultaneous Infection with Disseminated Nocardia and Pulmonary Aspergillus in a Patient Receiving Treatment with Ibrutinib for Chronic Lymphocytic Leukemia.

Cureus 2018 Oct 8;10(10):e3427. Epub 2018 Oct 8.

Infectious Disease, Joan C. Edwards School of Medicine - Marshall University, Huntington, USA.

Disseminated Nocardia infections are a rare occurrence that typically occur in immunocompromised hosts. Chronic lymphocytic leukemia (CLL) is a hematologic malignancy which makes patients susceptible to infections through various mechanisms. The treatments for CLL also target immunologic pathways which can contribute to infections. Read More

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October 2018

Protein kinase p38α signaling in dendritic cells regulates colon inflammation and tumorigenesis.

Proc Natl Acad Sci U S A 2018 Dec 12. Epub 2018 Dec 12.

Shanghai Institute of Immunology, College of Basic Medical Sciences, Shanghai Jiao Tong University School of Medicine, 200025 Shanghai, China;

Dendritic cells (DCs) play pivotal roles in maintaining intestinal homeostasis, but how the DCs regulate diverse immune networks on homeostasis breakdown remains largely unknown. Here, we report that, in response to epithelial barrier disruption, colonic DCs regulate the differentiation of type 1 regulatory T (Tr1) cells through p38α-dependent IL-27 production to initiate an effective immune response. Deletion of p38α in DCs, but not in T cells, led to increased Tr1 and protected mice from dextran sodium sulfate-induced acute colitis and chronic colitis-associated colorectal cancer. Read More

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December 2018