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    4916 results match your criteria Immunoglobulin G Deficiency

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    Serum Immunoglobulin G and Risk of Exacerbations and Hospitalizations in Chronic Obstructive Pulmonary Disease.
    J Allergy Clin Immunol 2017 Apr 26. Epub 2017 Apr 26.
    Centre for Heart Lung Innovation, St. Paul's Hospital, & Department of Medicine (Division of Respiratory Medicine), University of British Columbia, Vancouver, BC, Canada. Electronic address:
    Hypogammaglobulinemia (total IgG levels < 7.0 g/L) is present in 1 in 4 patients with moderate to severe COPD and is associated with 50% to 100% increase in the risk of exacerbations and hospitalizations. Read More

    The lack of BTK does not impair monocytes and polymorphonuclear cells functions in X-linked agammaglobulinemia under treatment with intravenous immunoglobulin replacement.
    PLoS One 2017 19;12(4):e0175961. Epub 2017 Apr 19.
    Department of Molecular Medicine, Sapienza University of Rome, Roma, Italy.
    The lack of BTK in X-linked agammaglobulinemia (XLA) patients does not affect monocytes and polymorphonuclear cells (PMN) phenotype and functions. In this study, we show that XLA patients had an increased frequency of the intermediate monocytes subset and that BTK-deficient monocytes and PMN had a normal expression of receptors involved in the activation and cellular responses. We demonstrate that BTK is not required for migration, phagocytosis and the production of reactive oxygen species (ROS) following engagement of FC gamma receptors (FcγR). Read More

    Clinical Profile, Dosing, and Quality-of-Life Outcomes in Primary Immune Deficiency Patients Treated at Home with Immunoglobulin G: Data from the IDEaL Patient Registry.
    J Manag Care Spec Pharm 2017 Apr;23(4):400-406
    1 Coram/CVS specialty infusion services, Denver, Colorado.
    Background: Patients with primary immune deficiency (PID) often require immunoglobulin G (IgG, commonly referred to as Ig) replacement therapy to prevent infections and associated comorbidities. Ig therapy can be given either through intravenous or subcutaneous routes, and both can be done in the home setting. There is limited information available on the real-world diagnosis, management, and outcomes of this patient population, given the variable disease presentation and treatment options. Read More

    Biochemical characterization and stability of immune globulin intravenous 10% liquid (Panzyga(®)).
    Biologicals 2017 Jan 27;45:33-38. Epub 2016 Oct 27.
    Octapharma Pharmazeutika Produktionsgesellschaft m.b.H., Vienna, Austria.
    Panzyga(®) is a new glycine-formulated immune globulin intravenous 10% liquid for the treatment of patients suffering from immunodeficiencies and autoimmune diseases. Panzyga(®) is a high purity, native and functional IgG product with an IgG subclass distribution equivalent to normal plasma. The levels of hemagglutinins and accompanying plasma proteins (including IgA and IgM) are low. Read More

    Changes in the Level of Immunoglobulins and CD4/CD8 Ratio in Young and Aged Mice with Estradiol Deficiency.
    Immunol Invest 2017 Apr 7;46(3):305-313. Epub 2017 Feb 7.
    a Department of Obstetrics and Gynecology , Jinhua Municipal Central Hospital , Zhejiang Province , People's Republic of China.
    Studies demonstrated that deficiency in 17β-estradiol (E2) in postmenopausal women influences their immune system. However, few studies have reported alterations in immunologic presentation during nonnatural menopause in young females. Here we compared the differences in immune response between young C57BL/6N mice with surgical or medical variectomy and aged C57BL/6N mice with the common feature of E2 deficiency following Con A stimulation. Read More

    Serial Serum Immunoglobulin G (IgG) Trough Levels in Patients with X-linked Agammaglobulinemia on Replacement Therapy with Intravenous Immunoglobulin: Its Correlation with Infections in Indian Children.
    J Clin Immunol 2017 Apr 21;37(3):311-318. Epub 2017 Mar 21.
    Division of Basic and Clinical Immunology, University of California, Irvine, CA, USA.
    Patients with primary antibody deficiency (PAD) are being increasingly diagnosed in the developing world. However, care of these children continues to remain suboptimal due to financial and social constraints. Immunoglobulin (Ig) trough level is an important predicting factor for infections in children on replacement immunoglobulin therapy. Read More

    Evaluation of the Safety, Tolerability, and Pharmacokinetics of Gammaplex(®) 10% Versus Gammaplex(®) 5% in Subjects with Primary Immunodeficiency.
    J Clin Immunol 2017 Apr 18;37(3):301-310. Epub 2017 Mar 18.
    Section of Allergy and Immunology, Department of Immunology and Microbiology, Rush University Medical Center, Chicago, IL, USA.
    Purpose: This phase 3, multicenter, open-label, randomized, two-period, crossover bioequivalence trial evaluated the safety, tolerability, and pharmacokinetics of intravenous immunoglobulins (IVIGs) Gammaplex 5% and Gammaplex 10% in 33 adults and 15 children with primary immunodeficiency diseases (PIDs).

    Methods: Eligible adults received five Gammaplex 5% infusions followed by five Gammaplex 10% infusions, or vice versa, stratified by a 21- or 28-day dosing regimen. Pediatric subjects received five Gammaplex 10% infusions only. Read More

    Humoral Reactivity of Renal Transplant-Waitlisted Patients to Cells From GGTA1/CMAH/B4GalNT2, and SLA Class I Knockout Pigs.
    Transplantation 2017 Apr;101(4):e86-e92
    1 Department of Surgery, University of Alabama at Birmingham, Birmingham, AL. 2 Department of Surgery, Indiana University, School of Medicine, Indianapolis, IN. 3 Transplant Surgery, University of Alabama at Birmingham, Birmingham, AL.
    Background: Antipig antibodies are a barrier to clinical xenotransplantation. We evaluated antibody binding of waitlisted renal transplant patients to 3 glycan knockout (KO) pig cells and class I swine leukocyte antigens (SLA).

    Methods: Peripheral blood mononuclear cells from SLA identical wild type (WT), α1, 3-galactosyltransferase (GGTA1) KO, GGTA1/ cytidine monophosphate-N-acetylneuraminic acid hydroxylase (CMAH) KO, and GGTA1/ CMAH /b1,4 N-acetylgalactosaminyl transferase (B4GalNT2) KO pigs were screened for human antibody binding using flow cytometric crossmatch (FCXM). Read More

    Intravenous Immunoglobulin in the Treatment of Primary Immunodeficiency Diseases.
    Pediatr Ann 2017 Jan;46(1):e8-e12
    Intravenous immunoglobulin (IVIG) has been used as antibody replacement therapy in primary immunodeficiency diseases (PIDDs) for more than 50 years. Its role as a therapeutic agent has expanded over the past couple of decades as its anti-inflammatory and immune-modulatory mechanisms of action have been elucidated. It is now used "off-label" to treat other autoimmune diseases. Read More

    Rapid infusions of human normal immunoglobulin 50g/l are safe and well tolerated in immunodeficiencies and immune thrombocytopenia.
    Int Immunopharmacol 2017 Mar 7;44:38-42. Epub 2017 Jan 7.
    Department of Molecular Medicine, "Sapienza" University of Rome, Italy.
    Intravenous immunoglobulin (IVIg) is accepted as an effective and well-tolerated treatment for primary and secondary immunodeficiencies (ID) and immune thrombocytopenia (ITP). Adverse reactions of IVIg are usually mild, comprising transient flu-like symptoms, change in blood pressure and tachycardia. However IVIg therapy can be burdensome for both patients and healthcare facilities, since the infusion may take up to 4h to administer. Read More

    Acquired Dysfibrinogenemia Caused by Autoantibody Inhibiting Fibrin Polymerization in a Patient with MELAS Syndrome and Bleeding Tendency.
    Ann Clin Lab Sci 2016 Dec;46(6):696-700
    Department of Laboratory Medicine, Seoul National University Hospital, Seoul, Korea
    We present a case of acquired dysfibrinogenemia caused by an autoantibody that inhibited fibrin polymerization in a patient previously diagnosed with MELAS (mitochondrial myopathy, encephalopathy, lactic acidosis, stroke-like episodes). The patient showed prolonged PT, aPTT, and thrombin time. There was no factor deficiency but fibrinogen antigen and activity were decreased. Read More

    Intravenous and subcutaneous immunoglobulin G replacement therapy.
    Allergy Asthma Proc 2016 Nov;37(6):426-431
    Clinical Immunology Program, Boston Childrens Hospital, Boston, Massachusetts, USA.
    Human polyclonal immunoglobulin G (IgG) for therapeutic use has been available for decades. This drug was developed for treatment of antibody deficiency (replacement therapy), although its use has expanded into many anti-inflammatory and immunomodulatory applications in recent years. This review focuses on IgG prescribing for replacement therapy. Read More

    Divergent clinical outcomes of alpha-glucosidase enzyme replacement therapy in two siblings with infantile-onset Pompe disease treated in the symptomatic or pre-symptomatic state.
    Mol Genet Metab Rep 2016 Dec 18;9:98-105. Epub 2016 Nov 18.
    Showa University Northern Yokohama Hospital, Children Medical Center, Yokohama, Kanagawa, Japan.
    Pompe disease is an autosomal recessive, lysosomal glycogen storage disease caused by acid α-glucosidase deficiency. Infantile-onset Pompe disease (IOPD) is the most severe form and is characterized by cardiomyopathy, respiratory distress, hepatomegaly, and skeletal muscle weakness. Untreated, IOPD generally results in death within the first year of life. Read More

    Developing an Inactivated Rotavirus Vaccine and Evaluating the Immunogenicity Against a Commercially Available Attenuated Rotavirus Vaccine Using a Mice Animal Model.
    Viral Immunol 2016 Dec 18;29(10):565-571. Epub 2016 Nov 18.
    1 Research and Development Sector, Egyptian Company for Production of Vaccines, Sera and Drugs-EgyVac (VACSERA Holding Company) , Giza, Egypt .
    There is a high demand for public immunization against Rotavirus (RV), especially in Africa. In Africa, the attenuated RV vaccination is contraindicated in patients with immune diseases and nutrition deficiency. Therefore, the inactivated RV vaccine (IRVV) could be an alternative. Read More

    Antibodies against Hepatitis A and Hepatitis B Virus in Intravenous Immunoglobulin Products.
    J Korean Med Sci 2016 Dec;31(12):1937-1942
    Center for Vaccine Evaluation and Study, Medical Research Institute, Ewha Womans University School of Medicine, Seoul, Korea.
    The worldwide seroprevalence of hepatitis A virus (HAV) and hepatitis B virus (HBV) has changed over the last two decades, indicating a declining incidence of HAV and HBV infections. Therefore, vaccinations against HAV and HBV are recommended for unimmunized people before traveling to an endemic area. Unfortunately, primary antibody deficiency (PAD) patients can only obtain humoral immunity through intravenous immunoglobulin G (IVIG) replacement and not from vaccination because of a defect in antibody production. Read More

    Helicobacter pylori infection and its related factors in junior high school students in Nagano Prefecture, Japan.
    Helicobacter 2017 Apr 27;22(2). Epub 2016 Oct 27.
    Department of Public Health, Aichi Medical University School of Medicine, Nagakute, Japan.
    Background: There have been few reports on Helicobacter pylori (H. pylori) infection in asymptomatic Japanese children and adolescents. We hypothesized that the prevalence of H. Read More

    Functional antibodies to Haemophilus influenzae type B, Neisseria meningitidis, and Streptococcus pneumoniae contained in intravenous immunoglobulin products.
    Transfusion 2017 Jan 23;57(1):157-165. Epub 2016 Oct 23.
    Center for Vaccine Evaluation and Study, Medical Research Institute, Seoul, Republic of Korea.
    Background: Intravenous immunoglobulin G (IVIG) replacement therapy is used to prevent invasive infections in patients with primary antibody deficiency (PAD). However, few studies have functionally evaluated specific antibodies against encapsulated bacteria that cause invasive infection in patients with PAD. In this study, functional antibodies against Haemophilus influenzae type b (Hib), Streptococcus pneumoniae (pneumococci), and Neisseria meningitidis (meningococci) in IVIG therapy were evaluated. Read More

    Tolerability and safety of Octagam® (IVIG): a post-authorization safety analysis of four non-interventional phase IV trials
    Int J Clin Pharmacol Ther 2016 Nov;54(11):847-855
    Objective: To evaluate the tolerability and safety of Octagam® 5% and 10% across all indications, ages, and treatment regimens, using data from four non-interventional post-authorization safety studies (PASS); this analysis was performed following changes in the preparation of raw material used to manufacture Octagam.

    Methods: All four studies included in- and out-patients prescribed Octagam for treatment of their medical condition. Physicians used case report forms to document baseline demographics, Octagam treatment details, and data on the efficacy of Octagam, and recorded all adverse drug reactions (ADRs) and other safety data. Read More

    Infectious diseases and immunological responses in adult subjects with lifetime untreated, congenital GH deficiency.
    Endocrine 2016 Oct 3;54(1):182-190. Epub 2016 Aug 3.
    Federal University of Sergipe, Division of Endocrinology, Aracaju, Sergipe, 49060-100, Brazil.
    Growth hormone is important for the development and function of the immune system, but there is controversy on whether growth hormone deficiency is associated to immune disorders. A model of isolated growth hormone deficiency may clarify if the lack of growth hormone is associated with increased susceptibility to infections, or with an altered responsiveness of the immune system. We have studied the frequency of infectious diseases and the immune function in adults with congenital, untreated isolated growth hormone deficiency. Read More

    FcμR in human B cell subsets in primary selective IgM deficiency, and regulation of FcμR and production of natural IgM antibodies by IGIV.
    Hum Immunol 2016 Dec 14;77(12):1194-1201. Epub 2016 Oct 14.
    Division of Basic and Clinical Immunology, University of California at Irvine, Irvine, CA, USA.
    IgMFcR (FcμR) are expressed on B cell and B cell subsets. Mice deficient in secreted IgM and FcμR share properties of impaired specific antibody response and autoimmunity with patient with selective IgM deficiency (SIGMD). Intravenous immunoglobulin (IGIV) regulates immune response, including modulation of IgGFc receptors. Read More

    Impact of Low Immunoglobulin G Levels on Disease Outcomes in Patients with Inflammatory Bowel Diseases.
    Dig Dis Sci 2016 Nov 12;61(11):3270-3277. Epub 2016 Sep 12.
    Center for Inflammatory Bowel Diseases, Digestive Disease and Surgery Institute-A31, The Cleveland Clinic Foundation, 9500 Euclid Ave., Cleveland, OH, 44195, USA.
    Background: Inflammatory bowel diseases (IBDs) are considered immune-mediated disorders with dysregulated innate and adaptive immunities. Secondary immunogloblin deficiency can occur in IBD and its impact on the disease course of IBD is not clear.

    Aims: We sought to determine associations between low IgG/G1 levels and poor clinical outcomes in IBD patients. Read More

    Efficacy, safety, tolerability and pharmacokinetics of a novel human immune globulin subcutaneous, 20%: a Phase 2/3 study in Europe in patients with primary immunodeficiencies.
    Clin Exp Immunol 2017 Jan 18;187(1):146-159. Epub 2016 Oct 18.
    Baxalta US Inc., now part of Shire, Cambridge, MA, USA.
    A highly concentrated (20%) immunoglobulin (Ig)G preparation for subcutaneous administration (IGSC 20%), would offer a new option for antibody replacement therapy in patients with primary immunodeficiency diseases (PIDD). The efficacy, safety, tolerability and pharmacokinetics of IGSC 20% were evaluated in a prospective trial in Europe in 49 patients with PIDD aged 2-67 years. Over a median of 358 days, patients received 2349 IGSC 20% infusions at monthly doses equivalent to those administered for previous intravenous or subcutaneous IgG treatment. Read More

    Miller Fisher syndrome.
    BMJ Case Rep 2016 Oct 13;2016. Epub 2016 Oct 13.
    University of Jordan, Amman, Jordan.
    A man aged 30 years presented to the emergency department (ED) with ataxia, areflexia, facial weakness, ophthalmoplegia, extremity weakness and back pain for 4 days. 4 days prior to attending the ED, the patient had suffered from diarrhoea for 2 weeks. The diagnosis of Miller Fisher syndrome was performed on the dual basis of clinical features in addition to an investigations report. Read More

    Deficiency in memory B cell compartment in a patient with infertility and recurrent pregnancy losses.
    J Reprod Immunol 2016 Nov 28;118:70-75. Epub 2016 Sep 28.
    Reproductive Medicine, Department of Obstetrics and Gynecology, Chicago Medical School at Rosalind Franklin University of Medicine and Science, Vernon Hills, IL, 60061, USA; Department of Microbiology and Immunology, Chicago Medical School at Rosalind Franklin University of Medicine and Science, North Chicago, IL, 60069, USA. Electronic address:
    Alterations in normal balance of B cell subsets have been reported in various rheumatic diseases. In this study, we report a woman with a history of recurrent pregnancy losses (RPL) and infertility who had low levels of memory B cells. A 35-year-old woman with a history of RPL and infertility was demonstrated to have increased peripheral blood CD19+ B cells with persistently low levels of memory B cell subsets. Read More

    Different forms of alpha-1 antitrypsin and neutrophil activation mediated by human anti-PR3 IgG antibodies.
    Pharmacol Rep 2016 Dec 5;68(6):1276-1284. Epub 2016 Aug 5.
    Department of Internal Medicine, Jagiellonian University Medical College, Kraków, Poland. Electronic address:
    Background: One of characteristic findings in granulomatosis with polyangiitis (GPA) is the presence of proteinase-3 (anti-PR3) specific antibodies. These antibodies can cause neutrophil activation, degranulation and generation of reactive oxygen species (ROS). Each of these inflammatory events can be suppressed by circulating alpha-1 antitrypsin (A1AT). Read More

    'Pre-endoscopy point of care test (Simtomax- IgA/IgG-Deamidated Gliadin Peptide) for coeliac disease in iron deficiency anaemia: diagnostic accuracy and a cost saving economic model'.
    BMC Gastroenterol 2016 Sep 15;16:115. Epub 2016 Sep 15.
    Academic Department of Gastroenterology, Royal Hallamshire Hospital, Sheffield Teaching Hospitals, Sheffield, UK.
    Background: International guidelines recommend coeliac serology in iron deficiency anaemia, and duodenal biopsy for those tested positive to detect coeliac disease. However, pre-endoscopy serology is often unavailable, thus committing endoscopists to take routine duodenal biopsies. Some endoscopists consider duodenal biopsy mandatory in anaemia to exclude other pathologies. Read More

    Effects of β-carotene-enriched dry carrots on β-carotene status and colostral immunoglobulin in β-carotene-deficient Japanese Black cows.
    Anim Sci J 2017 Apr 4;88(4):653-658. Epub 2016 Sep 4.
    Graduate School of Agriculture, Kyoto University, Kyoto, Japan.
    Data from 18 β-carotene-deficient Japanese Black cows were collected to clarify the effects of feeding β-carotene-enriched dry carrots on β-carotene status and colostral immunoglobulin (Ig) in cows. Cows were assigned to control or carrot groups from 3 weeks before the expected calving date to parturition, and supplemental β-carotene from dry carrots was 138 mg/day in the carrot group. Plasma β-carotene concentrations in the control and carrot groups at parturition were 95 and 120 μg/dL, and feeding dry carrots slightly improved plasma β-carotene at parturition. Read More

    Two cases of sporadic late onset nemaline myopathy effectively treated with immunotherapy.
    Rinsho Shinkeigaku 2016 Sep 31;56(9):605-11. Epub 2016 Aug 31.
    Department of Neurology, National Center Hospital, National Center of Neurology and Psychiatry.
    Sporadic late onset nemaline myopathy (SLONM) associated with monoclonal gammopathy of undetermined significance (MGUS) is an adult onset myopathy with poor clinical outcomes, requiring high-dose intravenous melphalan with autologous peripheral blood stem cell transplantation (HDM-SCT). Here we report two cases of SLONM associated with MGUS in which improvements were achieved only with immunotherapy. A 39-year-old woman had a two-year history of dropped head syndrome and progressive proximal weakness. Read More

    Investigation of the Immunomodulatory effect of Berberis vulgaris on core-pulsed dendritic cell vaccine.
    BMC Complement Altern Med 2016 Aug 30;16(1):325. Epub 2016 Aug 30.
    Biomedical Technology, GEBRI, SRTA-city, Alexandria, Egypt.
    Background: Virus-induced dendritic cells (DCs) functional deficiency leads to sub-optimal initiation of adaptive immune responses and consequently chronic infection establishment. The present study reports an advanced hepatitis C virus (HCV) therapeutic vaccine model based on In vivo enrichment of DCs with barberry ethanolic crude extract (BCE) then pulsing them with HCV core protein.

    Methods: DCs were enriched by BCE intravenous injection in BALB/c mice. Read More

    Immunoglobulin G Subclass Deficiencies in Adult Patients with Chronic Airway Diseases.
    J Korean Med Sci 2016 Oct;31(10):1560-5
    Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, Hallym University Medical Center, Anyang, Korea.
    Immunoglobulin G subclass deficiency (IgGSCD) is a relatively common primary immunodeficiency disease (PI) in adults. The biological significance of IgGSCD in patients with chronic airway diseases is controversial. We conducted a retrospective study to characterize the clinical features of IgGSCD in this population. Read More

    Helicobacter pylori infection and iron deficiency in patients with coronary artery disease.
    Cell Mol Biol (Noisy-le-grand) 2016 Jul 31;62(8):8-14. Epub 2016 Jul 31.
    University of Alberta Department of Medical Genetics, Faculty of Medicine and Dentistry Edmonton Canada.
    The aim of this study was to investigate whether impact of the seropositivity to Helicobacter pylori (H pylori) infection on ferritin and iron levels is an independent risk factor for atherosclerosis in patients with cardiovascular disease. The anti H pylori IgG, IgA levels, serum ferritin and iron concentration of 86 patients with cardiovascular disease and 64 participants free of cardiovascular disease as control subjects were determined by ELISA assay. The results of present study showed that seropositivity to H pylori IgG and IgA levels of coronary artery disease (CAD) patients was higher than controls and CAD patients with negative anti H pylori IgG and IgA significantly. Read More

    Important Factors Influencing Severity of Common Variable Immunodeficiency.
    Arch Iran Med 2016 Aug;19(8):544-50
    Research Center for Immunodeficiencies, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran.
    Background: Common variable immunodeficiency (CVID) is a primary immune deficiency with heterogeneous complications. The purpose of this study is to determine disease severity in a cohort of CVID patients based on the suggested scoring system and investigate predisposing factors which would be helpful to predict the severity of the disease.

    Methods: The study population comprised 113 CVID patients (69 males and 44 females) who were visited at Children's Medical Center (Pediatrics Center of Excellence affiliated to Tehran University of Medical Sciences, Tehran, Iran) during the last 30 years (from 1984-2014). Read More

    [Study on immunoglobulin A Deficiency(IgAD) in Chinese Shanghai Blood Donors].
    Zhongguo Shi Yan Xue Ye Xue Za Zhi 2016 Aug;24(4):1216-20
    Karolinska Institutet at Karolinska University Hospital, Stockholm, Sweden.
    Unlabelled: Objective:To calculate the prevalence of IgAD in a replicate cohort of the Chinese Han population in Shanghai area by screening blood donors and to study the genetic difference of IgAD individuals in the Mongoloid population.

    Methods: The prevalence of IgAD in a large number of Chinese blood donors (n=61624) in Shanghai area was investigated. The immunoglobulin class, IgG subclass and anti-IgA serum levels were measured among the IgAD donors. Read More

    Prospective evaluation of Streptococcus pneumoniae serum antibodies in patients with primary immunodeficiency on regular intravenous immunoglobulin treatment.
    Allergol Immunopathol (Madr) 2017 Jan - Feb;45(1):55-62. Epub 2016 Jul 29.
    Division of Pediatric Infectious Diseases, Department of Pediatrics, Universidade Federal de São Paulo, São Paulo, SP, Brazil. Electronic address:
    Background: This is a prospective study that assessed pneumococcal antibody levels in PID patients under intravenous immunoglobulin (IVIG) treatment using different brands.

    Methods: Twenty-one patients receiving regular IVIG every 28 days were invited to participate: 12 with common variable immunodeficiency, six with X-linked agammaglobulinaemia and three with hyper-IgM syndrome. One blood sample was collected from each patient just prior to IVIG administration at a three-month time interval during one year. Read More

    Venous Thromboembolism After Knee Arthroscopy in Undiagnosed Familial Thrombophilia.
    Orthopedics 2016 Nov 27;39(6):e1052-e1057. Epub 2016 Jul 27.
    Venous thromboembolism is uncommon after knee arthroscopy, and there are no guidelines for thromboprophylaxis in elective routine knee arthroscopy. Preoperative evaluation of common thrombophilias should provide guidance for postarthroscopy thromboprophylaxis in otherwise healthy patients who are at high risk for venous thromboembolism. This study assessed 10 patients with venous thromboembolism after total hip or knee arthroplasty. Read More

    Anaphylaxis to IVIG.
    Arch Immunol Ther Exp (Warsz) 2017 Feb 13;65(1):11-19. Epub 2016 Jul 13.
    Division of Basic and Clinical Immunology, University of California Irvine, Irvine, CA, USA.
    Anaphylactic reactions are a known complication in some IgA-deficient patients receiving blood or plasma transfusions. It is of particular interest that anaphylaxis has been observed in patients with common variable immunodeficiency (CVID) who are receiving intravenous gammaglobulin (IVIG), and in that, although these patients have an impaired response to common vaccines, they retain the ability to produce autoantibodies. In this study, we review IgA antibodies (both IgG- and IgE-mediated reactions) in patients with CVID and hypogammaglobulinemia, anaphylaxis in antibody immunodeficient patients receiving IVIG, and proposed mechanisms of desensitization and prevention of anaphylactic reactions in immunodeficient patients receiving IVIG. Read More

    Immunoglobulin A deficiency following treatment with lamotrigine.
    Brain Dev 2016 Nov 7;38(10):947-949. Epub 2016 Jul 7.
    Department of Pediatrics, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan.
    Lamotrigine (LTG) is an anti-epileptic drug and mood-stabilizing agent, whose adverse effects include skin rash and dizziness. Interactions with the immune system are rare, and only a few cases linking hypogammaglobulinemia to LTG treatment have been previously described. In this report, we describe a case in which a patient developed hypogammaglobulinemia, and a subsequent immunoglobulin A (IgA) deficiency, following LTG treatment. Read More

    [Seroprevalence of human parvovirus B19 in children with fever and rash in the North of Tunisia].
    Bull Soc Pathol Exot 2016 Aug 7;109(3):165-71. Epub 2016 Jul 7.
    Unité de recherche UR12ES01, faculté de médecine de Tunis, université de Tunis El-Manar, Tunis, Tunisie.
    The aim of the study is to evaluate the prevalence of specific antibodies anti-human parvovirus B19 (PVB19) immunoglobulin M (IgM) and IgG in children with fever and rash. This study involved 257 children aged from 7 months to 15 years with febrile rash unrelated to measles and rubella (seronegative for IgM). The sera were examined by immunoenzymatic assay. Read More

    Nivolumab-induced chronic inflammatory demyelinating polyradiculoneuropathy mimicking rapid-onset Guillain-Barré syndrome: a case report.
    Jpn J Clin Oncol 2016 Sep 5;46(9):875-8. Epub 2016 Jul 5.
    Department of Dermatology, Faculty of Medicine, University of Tsukuba, Ibaraki.
    Nivolumab, an anti-programmed death-1-specific monoclonal antibody, has demonstrated a durable response and effect on overall survival and has become one of the standard treatments for patients with advanced melanoma. Reported herein is a case of nivolumab-induced chronic inflammatory demyelinating polyradiculoneuropathy, in which an 85-year-old woman with stage IV melanoma developed grade 1 paresthesia 2 weeks after the initial dose of nivolumab was administered. With continued treatment, the neurological deficiency deteriorated rapidly, mimicking Guillain-Barré syndrome, causing such a dramatic decrease in her activities of daily living that she could no longer function in daily life. Read More

    Lupus anticoagulant-hypoprothrombinemia syndrome and catastrophic antiphospholipid syndrome in a patient with antidomain I antibodies.
    Blood Coagul Fibrinolysis 2016 Jul;27(5):580-2
    aNancy University Hospital, Vascular Medicine Division and Regional Competence, Center for Rare Vascular And Systemic Autoimmune DiseasesbDijon University Hospital, Haematology laboratory, Nancy, FrancecBiochemistry, Cardiovascular Research Institute Maastricht (CARIM), Maastricht, University, Maastricht, the NetherlandsdNancy University Hospital, Nuclear Medecine & Nancyclotep Experimental Imaging, PlatformeUniversité de LorrainefInserm, UMR_S 1116gNancy University Hospital, Department of Critical Care Medicine, Nancy, France.
    Lupus anticoagulant-hypoprothrombinemia syndrome is a rare condition characterized by the association of acquired factor II deficiency and lupus anticoagulant. Contrary to classical antiphospholipid syndrome, it may cause severe life-threatening bleeding (89% of published cases). We report a patient, positive for antidomain I antibodies, with initially primary lupus anticoagulant-hypoprothrombinemia syndrome without previous clinical manifestation or underlying systemic disease. Read More

    The case for a national service for primary immune deficiency disorders in New Zealand.
    N Z Med J 2016 Jun 10;129(1436):75-90. Epub 2016 Jun 10.
    Departments of Clinical Immunology, Virology and immunology, Auckland City Hospital, Auckland, New Zealand.
    Primary immune deficiency disorders (PIDs) are rare conditions for which effective treatment is available. It is critical these patients are identified at an early stage to prevent unnecessary morbidity and mortality. Treatment of these disorders is expensive and expert evaluation and ongoing management by a clinical immunologist is essential. Read More

    Management of granulomatous lymphocytic interstitial lung disease in a patient with common variable immune deficiency.
    BMJ Case Rep 2016 Jun 22;2016. Epub 2016 Jun 22.
    Department of Internal Medicine, University of Florida, Gainesville, Florida, USA.
    A 61-year-old woman presented with longstanding cough and progressive dyspnoea. She underwent an extensive evaluation and was diagnosed with common variable immunodeficiency (CVID) with granulomatous lymphocytic interstitial lung disease (GLILD). She was initially treated with subcutaneous immunoglobulin therapy, having declined intravenous immunoglobulin (IVIG) therapy. Read More

    Complement and Antibody-mediated Enhancement of Red Blood Cell Invasion and Growth of Malaria Parasites.
    EBioMedicine 2016 Jul 14;9:207-16. Epub 2016 May 14.
    Department of Microbiology and Immunology, Pennsylvania State University, College of Medicine, 500 University Drive, Hershey, PA 17033, United States; Department of Medicine, Division of Infectious Diseases and Epidemiology, Pennsylvania State University, College of Medicine, 500 University Drive, Hershey, PA 17033, United States. Electronic address:
    Plasmodium falciparum malaria is a deadly pathogen. The invasion of red blood cells (RBCs) by merozoites is a target for vaccine development. Although anti-merozoite antibodies can block invasion in vitro, there is no efficacy in vivo. Read More

    Deficiency of cold-inducible ribonucleic acid-binding protein reduces renal injury after ischemia-reperfusion.
    Surgery 2016 Aug 3;160(2):473-83. Epub 2016 Jun 3.
    Department of Surgery, Hofstra Northwell School of Medicine, Manhasset, NY; Center for Translational Research, The Feinstein Institute for Medical Research, Manhasset, NY. Electronic address:
    Background: Renal ischemia-reperfusion injury, commonly caused by major operation and shock, leads to acute kidney injury and is associated with high morbidity and mortality. Cold-inducible ribonucleic acid-binding protein, a cold shock protein, has recently been identified as a damage-associated molecular pattern. We hypothesized that cold-inducible ribonucleic acid-binding protein exacerbates severity of injury in renal ischemia-reperfusion. Read More

    Response to pneumococcal polysaccharide vaccine in children with asthma, and children with recurrent respiratory infections, and healthy children.
    Allergol Immunopathol (Madr) 2016 Jul-Aug;44(4):376-81. Epub 2016 May 30.
    Public Health School University of Chile, Santiago de Chile, Chile.
    Background: To analyse specific immune response to the 23-valent pneumococcal polysaccharide vaccine by measuring pneumococcal antibodies in children with asthma and with respiratory recurrent infection (RRI) as compared to healthy children.

    Methods: The study included 60 children, divided into three groups: 20 with asthma, 20 with RRI, and 20 healthy controls. Post-vaccination specific IgG antibodies against 10 pneumococcal serotypes (S1, S3, S4, S5, S6B, S9V, S14, S18C, S19F, and S23F) contained in the 23-valent pneumococcal polysaccharide vaccine (PPV) were measured. Read More

    Global TLR2 and 4 deficiency in mice impacts bone resorption, inflammatory markers and atherosclerosis to polymicrobial infection.
    Mol Oral Microbiol 2017 Jun 20;32(3):211-225. Epub 2016 Jul 20.
    Department of Periodontology, College of Dentistry, University of Florida, Gainesville, FL, USA.
    Toll-like-receptors (TLRs) play a significant role in the generation of a specific innate immune response against invading pathogens. TLR2 and TLR4 signaling contributes to infection-induced inflammation in periodontal disease (PD) and atherosclerosis. Observational studies point towards a relationship between PD and atherosclerosis, but the role of TLR2 and TLR4 in the recognition of multiple oral pathogens and their modulation of host response leading to atherosclerosis are not clear. Read More

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