Bacterial exploitation of phosphorylcholine mimicry suppresses inflammation to promote airway infection.
- Christopher B Hergott,
- Aoife M Roche,
- Nikhil A Naidu,
- Clementina Mesaros,
- Ian A Blair,
- Jeffrey N Weiser
J Clin Invest 2015 Oct 31;125(10):3878-90. Epub 2015 Aug 31.
Regulation of neutrophil activity is critical for immune evasion among extracellular pathogens, yet the mechanisms by which many bacteria disrupt phagocyte function remain unclear. Here, we have shown that the respiratory pathogen Streptococcus pneumoniae disables neutrophils by exploiting molecular mimicry to degrade platelet-activating factor (PAF), a host-derived inflammatory phospholipid. Using mass spectrometry and murine upper airway infection models, we demonstrated that phosphorylcholine (ChoP) moieties that are shared by PAF and the bacterial cell wall allow S. Read More