IgM Augments Complement Bactericidal Activity with Serum from a Patient with a Novel CD79a Mutation.
- Jeroen D Langereis,
- Stefanie S Henriet,
- Saskia Kuipers,
- Corry M R Weemaes,
- Mirjam van der Burg,
- Marien I de Jonge,
- Michiel van der Flier
J Clin Immunol 2018 Jan 15. Epub 2018 Jan 15.
Section Pediatric Infectious Diseases, Laboratory of Medical Immunology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, The Netherlands.
Antibody replacement therapy for patients with antibody deficiencies contains only IgG. As a result, concurrent IgM and IgA deficiency present in a large proportion of antibody deficient patients persists. Especially patients with IgM deficiency remain at risk for recurrent infections of the gastrointestinal and respiratory tract. Read More