MST1 deficiency promotes B cell responses by CD4(+) T cell-derived IL-4, resulting in hypergammaglobulinemia.
- Eunchong Park,
- Myun Soo Kim,
- Ju Han Song,
- Kyung Min Cho,
- Kyung-Hye Roh,
- Rana Lee,
- Tae Sung Kim
Biochem Biophys Res Commun 2017 May 17. Epub 2017 May 17.
Division of Life Sciences, College of Life Sciences and Biotechnology, Korea University, Seoul 02841, Republic of Korea. Electronic address:
MST1 deficiency causes T and B cell lymphopenia, resulting in combined immunodeficiency. However, MST1-deficient patients also exhibit autoimmune-like symptoms such as hypergammaglobulinemia and autoantibody production. Recent studies have shown that the autoimmune responses observed in MST1-deficient patients were most likely attributable to defective regulatory T (Treg) cells instead of intrinsic signals in MST1-lacking B cells. Read More