3,671 results match your criteria Immunobiology [Journal]


NK cell expression of Tim-3: First impressions matter.

Immunobiology 2019 Mar 2. Epub 2019 Mar 2.

Department of Otorhinolaryngology-Head and Neck Surgery, University of Maryland School of Medicine, Baltimore, MD, 21201, USA. Electronic address:

Given the heightened interest in manipulation of co-signaling cascades for cancer immunotherapy, we sought to determine how/whether tumors decorated with therapeutic monoclonal antibodies (mAbs) impact the expression of co-signaling molecules on human NK cells. Stimulation of NK cells with aggregated IgG1 resulted in the upregulation of HAVCR2 - the gene encoding T-cell immunoglobulin and mucin-containing domain (Tim)-3 - known to be involved in the induction of peripheral T cell tolerance. This upregulation of HAVCR2 was recapitulated at the protein level, following NK cell stimulation by either mAb opsonized tumors, recombinant human IgG1 Fc multimer, and/or non-Fc stimuli e. Read More

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http://dx.doi.org/10.1016/j.imbio.2019.03.001DOI Listing

Advancement in TPL2-regulated innate immune response.

Immunobiology 2019 Mar 5. Epub 2019 Mar 5.

State Key Laboratory of Veterinary Etiological Biology, National Foot-and-Mouth Disease Reference Laboratory, Lanzhou Veterinary Research Institute, Chinese Academy of Agriculture Science, Lanzhou, 73004, China.

Tumor progression locus 2 (TPL2) is a serine/threonine kinase that belongs to the MAP3K family. The activated TPL2 regulates the innate immune-relevant signaling pathways, such as ERK, JNK, and NF-κB, and the differentiation of immune cells, for example, CD4+ T and NK cells. Therefore, TPL2 plays a critical role in regulating the innate immune response. Read More

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http://dx.doi.org/10.1016/j.imbio.2019.02.010DOI Listing

Interleukin-36 alpha levels are elevated in the serum and cerebrospinal fluid of patients with neuromyelitis optica spectrum disorder and correlate with disease activity.

Immunobiology 2019 Mar 1. Epub 2019 Mar 1.

Department of Neurology and Neuroscience Center, The First Hospital of Jilin University, Changchun, China. Electronic address:

Neuromyelitis optica spectrum disorder (NMOSD) is an autoimmune inflammatory neurological disease characterized by longitudinally extensive transverse myelitis (LETM) and optic neuritis. Interleukin (IL)-36 is a novel cytokine of the IL-1 family that is involved in the development of inflammatory diseases. The aim of this study was to investigate the role of IL-36α in NMOSD. Read More

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http://dx.doi.org/10.1016/j.imbio.2019.02.008DOI Listing

Interactions of ficolin-3 with ovarian cancer cells.

Immunobiology 2019 Jan 30. Epub 2019 Jan 30.

Laboratory of Immunobiology of Infections, Institute of Medical Biology, Polish Academy of Sciences, Lodz, Poland.

Background: Ficolin-3 is a pattern-recognition molecule with the ability to activate the lectin pathway of complement. It is found in lung, liver and blood, but its physiological role is unclear. We have investigated interaction of recombinant ficolin-3 with malignant cells and tissues. Read More

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http://dx.doi.org/10.1016/j.imbio.2019.01.002DOI Listing
January 2019

Interferon-γ upregulates Δ42PD1 expression on human monocytes via the PI3K/AKT pathway.

Immunobiology 2019 Feb 21. Epub 2019 Feb 21.

HKU-AIDS Institute Shenzhen Research Laboratory, Shenzhen Key Laboratory of Infection and Immunity, Guangdong Key Laboratory of Emerging Infectious Diseases, Shenzhen Third People's Hospital, Shenzhen, China; AIDS Institute, Research Center for Infection and Immunity, Department of Microbiology, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong SAR, China. Electronic address:

Background: We recently identified a novel alternatively spliced isoform of human programmed cell death 1 (PD-1), named Δ42PD1, which contains a 42-base-pair in-frame deletion compared with the full-length PD-1. Δ42PD1 is likely constitutively expressed on human monocytes and down-regulated in patients infected with human immunodeficiency virus type 1 (HIV-1). The mechanism underlying the regulation of Δ42PD-1 expression in monocytes remains unknown. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01712985183014
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http://dx.doi.org/10.1016/j.imbio.2019.02.009DOI Listing
February 2019
3 Reads

Exosomes derived from monocytes and from endothelial cells mediate monocyte and endothelial cell activation under high d-glucose conditions.

Immunobiology 2019 Feb 22. Epub 2019 Feb 22.

Immunoendocrinology, Division of Medical Biology, Department of Pathology and Medical Biology, University of Groningen, University Medical Center Groningen, Hanzeplein 1, 9713 GZ, Groningen, the Netherlands; Department of Obstetrics and Gynecology, University of Groningen, University Medical Center Groningen, Hanzeplein 1, 9713 GZ, Groningen, the Netherlands. Electronic address:

Diabetes mellitus type 2 (DMT2) is characterized by hyperglycemia and associated with low grade inflammation affecting both endothelial cells and monocytes. Exosomes are nanovesicles, allow communication between endothelial cells and monocytes and have been associated with diabetic complications. In this study we evaluated whether high glucose can activate monocytes and endothelial cells and whether exosomes play a role in this activation. Read More

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http://dx.doi.org/10.1016/j.imbio.2019.02.004DOI Listing
February 2019

The role of autoimmunity in women with type 1 diabetes and adverse pregnancy outcome: A missing link.

Immunobiology 2019 Feb 15. Epub 2019 Feb 15.

Department of Obstetrics and Gynecology, University of Groningen, University Medical Center Groningen, the Netherlands; Department of Pathology and Medical Biology, Div. of Medical Biology, University of Groningen, University Medical Center Groningen, the Netherlands. Electronic address:

The incidence of pregnancy complications in women with type 1 Diabetes Mellitus (T1D) is greater than in healthy pregnant women. This has mostly been attributed to hyperglycemia. However, despite the implementation of stricter guidelines regarding glycemic control, pregnancy complications remain more common in women with T1D. Read More

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http://dx.doi.org/10.1016/j.imbio.2019.02.003DOI Listing
February 2019
1 Read

ATP signaling and NTPDase in Systemic Lupus Erythematosus (SLE).

Immunobiology 2019 Feb 8. Epub 2019 Feb 8.

Departamento de Bioquímica e Biologia Molecular, Centro de Ciências Naturais e Exatas, Universidade Federal de Santa Maria, Av. Roraima, 97105-900, Santa Maria, RS, Brazil. Electronic address:

Systemic lupus erythematosus (SLE) is an autoimmune and inflammatory disease with periods of exacerbation and remission. SLE is characterized by the irreversible breakdown of immunological self-tolerance, where there is deregulation of multiple aspects of the immune system. SLE immune dysfunction is characterized by activation of autoreactive T lymphocytes, and hyperactivity of B lymphocytes with consequent production of several autoantibodies. Read More

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http://dx.doi.org/10.1016/j.imbio.2019.02.005DOI Listing
February 2019
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T cell epitopes of Per a 10 modulate local-systemic immune responses and airway inflammation by augmenting Th1 and T regulatory cell functions in murine model.

Immunobiology 2019 Jan 30. Epub 2019 Jan 30.

CSIR-Institute of Genomics and Integrative Biology, Mall road, Delhi, India. Electronic address:

Peptide immunotherapy (PIT) represents a safe and efficacious therapeutic modality for allergic diseases. Present study evaluates immunotherapeutic potential of T cell peptides of major cockroach allergen, Per a 10 in murine model of airway allergy. Treatment with peptides T-P8 and T-P10 demonstrated maximal resolution of pathophysiological features such as reduced recruitment of inflammatory cells to airways, lowered specific IgE, induction of IgG2a antibodies in serum, immune deviation towards Th1 cytokine milieu, suppression of Th2 cytokines in BALF and splenocyte culture supernatant and resolution of lung inflammation. Read More

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http://dx.doi.org/10.1016/j.imbio.2019.01.003DOI Listing
January 2019
3.044 Impact Factor

Dispensable role of chemokine receptors in migration of mycobacterial antigen-specific CD4 T cells into Mycobacterium-infected lung.

Immunobiology 2019 Feb 16. Epub 2019 Feb 16.

Molecular Microbiology Group, Tropical Biosphere Research Center, University of the Ryukyus, Okinawa 903-0213, Japan; Department of Host Defense, Graduate School of Medicine, University of the Ryukyus, Okinawa 903-0213, Japan.

Mycobacterial antigen-specific CD4 Th1 cells have pivotal role in protective immunity against mycobacterial infections including pulmonary tuberculosis. In the course of the infection, Th1 cells differentiate in the lung-draining lymph nodes and migrate into the infected lung. Chemokine receptors on T cells are involved in T cell migration into the intestine and skin. Read More

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http://dx.doi.org/10.1016/j.imbio.2019.01.006DOI Listing
February 2019
1 Read

Assessment of expression of RELN signaling pathway in multiple sclerosis patients.

Immunobiology 2019 Feb 12. Epub 2019 Feb 12.

Department of Medical Genetics, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran; Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran. Electronic address:

Multiple sclerosis (MS) is a chronic demyelinating disease of the central nervous system. Nearly 85% of MS patients are recognized with relapsing-remitting MS (RRMS), a typical clinical course of disease which is distinguished by several episodes of relapses, separated by remissions of neurological impairment. Failure of repair mechanisms is a main factor in progression of neurological dysfunction in MS. Read More

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http://dx.doi.org/10.1016/j.imbio.2019.02.007DOI Listing
February 2019
3.044 Impact Factor

Aberrant IGF1-PI3K/AKT/MTOR signaling pathway regulates the local immunity of oral lichen planus.

Immunobiology 2019 Feb 10. Epub 2019 Feb 10.

The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) and Key Laboratory of Oral Biomedicine Ministry of Education, School and Hospital of Stomatology, Wuhan University, Wuhan, 430079, PR China; Department of Oral Medicine, School and Hospital of Stomatology, Wuhan University, Wuhan 430079, PR China. Electronic address:

Objectives: Oral lichen planus (OLP) is a T cell-mediated immune-related chronic disease, featured by accumulation of T cells and apoptosis of keratinocytes. Insulin-like growth factors 1 (IGF1) signaling, in combination with its downstream PI3K/AKT/MTOR cascade, plays pivotal roles in the regulation of inflammation and immune response. Meanwhile, TRB3 acts as a connective protein in the pathway. Read More

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http://dx.doi.org/10.1016/j.imbio.2019.01.004DOI Listing
February 2019

GRACE score of myocardial infarction patients correlates with oxidative stress index, hsCRP and inflammation.

Immunobiology 2019 Feb 10. Epub 2019 Feb 10.

Department of Biochemistry, Jawaharlal Nehru Medical College, Faculty of Medicine, Aligarh Muslim University, Aligarh, 202002, Uttar Pradesh, India. Electronic address:

Background: Etiopathogenesis of myocardial infarction (MI) is contributed by oxidative injury and inflammatory response. The interplay of these processes determines outcomes in MI patients. However, studies showing the relationship of oxidative stress and inflammatory cytokines with prognosis and severity of MI are lacking. Read More

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http://dx.doi.org/10.1016/j.imbio.2019.02.001DOI Listing
February 2019

The CCR6-CCL20 axis in humoral immunity and T-B cell immunobiology.

Immunobiology 2019 Feb 8. Epub 2019 Feb 8.

Menzies Institute for Medical Research, University of Tasmania, Hobart, Australia; Institute of Clinical Pharmacology, Anhui Medical University, Key Laboratory of Anti-inflammatory and Immunopharmacology, Ministry of Education, Engineering Technology Research Center of Anti-inflammatory and Immunodrugs in Anhui Province, Hefei, Anhui Province, People's Republic of China. Electronic address:

Traditionally, chemokine immunobiology has focused on chemotaxis and the positioning of cells at sites of inflammation and within lymphoid organs. More recently, however, regulation of intricate immune responses has emerged as a function attributed to chemokines and their receptors. One such pair, CCR6 and its chemokine ligand CCL20, has been receiving interest for its potential role in the coordination and regulation of humoral immune responses and in particular, memory responses, at the cellular level. Read More

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http://dx.doi.org/10.1016/j.imbio.2019.01.005DOI Listing
February 2019
1 Read

Defective cytokine production from monocytes/macrophages of E-beta thalassemia patients in response to Pythium insidiosum infection.

Immunobiology 2019 Feb 8. Epub 2019 Feb 8.

Department of Immunology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand. Electronic address:

Background: Pythium insidiosum has been mainly reported to cause morbidity and mortality in thalassemia patients. P. insidiosum zoospores can germinate to be hyphae within a few hours; therefore, it is difficult to study the initial immune response that P. Read More

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http://dx.doi.org/10.1016/j.imbio.2019.02.002DOI Listing
February 2019
1 Read

Comparison of dendritic cells obtained from autoimmunty-prone and resistant rats.

Immunobiology 2019 Feb 8. Epub 2019 Feb 8.

Department of Immunology, Institute for Biological Research "Siniša Stanković", University of Belgrade, Serbia. Electronic address:

Dendritic cells (DC) are responsible for the initiation and shaping of the adaptive immune response and are in the focus of autoimmunity research. We were interested in comparison of DC obtained from autoimmunity-prone Dark Agouti (DA) rats and autoimmunity-resistant Albino Oxford (AO) rats. DC were generated from bone marrow precursors and matured (mDC) by lipopolysaccharide. Read More

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http://dx.doi.org/10.1016/j.imbio.2019.01.001DOI Listing
February 2019

Reactive oxygen species (ROS) in macrophage activation and function in diabetes.

Immunobiology 2018 Dec 1. Epub 2018 Dec 1.

The Institute of Transfusion Medicine and Immunology, Medical Faculty Mannheim, University of Heidelberg, Germany; Laboratory for Translational Cellular and Molecular Biomedicine, Tomsk State University, Tomsk, Russia; Red Cross Blood Service Baden-Württemberg-Hessen, Germany. Electronic address:

In a diabetic milieu high levels of reactive oxygen species (ROS) are induced. This contributes to the vascular complications of diabetes. Recent studies have shown that ROS formation is exacerbated in diabetic monocytes and macrophages due to a glycolytic metabolic shift. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01712985183021
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http://dx.doi.org/10.1016/j.imbio.2018.11.010DOI Listing
December 2018
13 Reads

Enhancing the pro-inflammatory anti-cancer T cell response via biomanufactured, secretome-based, immunotherapeutics.

Immunobiology 2018 Dec 28. Epub 2018 Dec 28.

Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, V6T 1Z3, Canada; University of British Columbia Centre for Blood Research, Canada; Canadian Blood Services, Canada. Electronic address:

T lymphocytes play a critical role in the pro-inflammatory anti-cancer response; hence, significant pharmacologic efforts have been made to enhance the endogenous T cell response. Unfortunately, significant toxicity arises consequent to pan T cell activation. In contrast, the less robust T cell alloresponse has also demonstrated an anti-cancer effect, but poses an inherent risk of GvHD. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01712985183012
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http://dx.doi.org/10.1016/j.imbio.2018.12.003DOI Listing
December 2018
2 Reads

Coxiella burnetii in non-Hodgkin lymphoma tissue samples: Innocent until proven otherwise?

Immunobiology 2018 Dec 5. Epub 2018 Dec 5.

Department of Medical Microbiology and Infection Control, Jeroen Bosch Hospital,' s-Hertogenbosch, the Netherlands. Electronic address:

Purpose: Coxiella burnetii has been suggested as a potential cause of B-cell non-Hodgkin lymphoma (B-NHL), as C. burnetii was detected in B-NHL tissues. To further investigate this potential relationship, we hypothesized that among subjects previously exposed to C. Read More

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http://dx.doi.org/10.1016/j.imbio.2018.11.012DOI Listing
December 2018
3 Reads

Geniposide regulates the miR-101/MKP-1/p38 pathway and alleviates atherosclerosis inflammatory injury in ApoE mice.

Immunobiology 2018 Dec 27. Epub 2018 Dec 27.

School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, Guangdong, China. Electronic address:

Atherosclerosis (AS) is the common pathological basis of chronic cardiovascular diseases and is associated with inflammation and lipid metabolism dysfunction. Geniposide, the main active ingredient of Gardenia jasminoides Ellis fruit, exhibits a variety of anti-inflammatory and anti-oxidative functions; however, its role in AS remains unclear. The aim of this study was to investigate the mechanisms of geniposide in alleviating inflammation and thereby attenuating the development of AS. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01712985183014
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http://dx.doi.org/10.1016/j.imbio.2018.12.005DOI Listing
December 2018
7 Reads
3.044 Impact Factor

Glucocorticoid hormone differentially modulates the in vitro expansion and cytokine profile of thymic and splenic Treg cells.

Immunobiology 2018 Dec 27. Epub 2018 Dec 27.

Department of Immunology and Biotechnology, Clinical Center, University of Pécs Medical School, Pécs, H-7624, Hungary. Electronic address:

Objective: Functional disturbances in regulatory T cells (Treg) have been described in autoimmune diseases, and their potential therapeutic use is intensively studied. Our goal was to investigate the influence of glucocorticoid hormone on the in vitro differentiation of Treg cells from thymic and splenic CD4 T cells under different conditions to establish methods for generating stable and functionally suppressive iTregs for future use in adoptive transfer experiments.

Methods: Thymic and splenic CD4 T lymphocytes were isolated from 3 to 4 week-old control and in vivo dexamethasone (DX) pretreated BALB/c mice using magnetic bead negative selection, followed by CD25 positive selection. Read More

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http://dx.doi.org/10.1016/j.imbio.2018.12.002DOI Listing
December 2018
1 Read

Expression of complement C3, C5, C3aR and C5aR1 genes in resting and activated CD4 T cells.

Immunobiology 2018 Dec 27. Epub 2018 Dec 27.

Laboratory of Molecular Medicine, Department of Clinical Immunology Section 7631, Faculty of Health and Medical Sciences, University Hospital of Copenhagen, Denmark. Electronic address:

Complement activation is traditionally thought to occur in the extracellular space. However, it has been suggested that complement proteins are activated and function at additional locations. T cells contain intracellular stores of C3 and C5 that can be cleaved into C3a and C5a and bind to intracellular receptors, which have been shown to be of vital importance for the differentiation and function of these cells. Read More

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http://dx.doi.org/10.1016/j.imbio.2018.12.004DOI Listing
December 2018
1 Read

Oral immunization with a plant-derived chimeric protein in mice: Toward the development of a multipotent edible vaccine against E. coli O157: H7 and ETEC.

Immunobiology 2018 Dec 11. Epub 2018 Dec 11.

Department of Agricultural Biotechnology. National Institute of Genetic Engineering and Biotechnology (NIGEB), Tehran, Iran. Electronic address:

The most bacterial cause of infectious diseases associated with diarrhea are enterotoxigenic and enterohemorrhagic Escherichia coli (ETEC and EHEC, respectively). These strains use colonization factors for the attachment to the human intestinal mucosa, followed by enterotoxins production that could induce more host damage. The Heat-labile enterotoxin (LT) and colonization factors (CFs) are momentous factors for the pathogenesis of ETEC. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01712985183016
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http://dx.doi.org/10.1016/j.imbio.2018.12.001DOI Listing
December 2018
3 Reads
3.044 Impact Factor

Vaccination with MIP or Pgp3 induces cross-serovar protection against chlamydial genital tract infection in mice.

Immunobiology 2018 Dec 5. Epub 2018 Dec 5.

Pathogenic Biology Institute, Hengyang Medical College, Hunan Provincial Key Laboratory for Special Pathogens Prevention and Control, University of South China, Hengyang, 421001, China; Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, Hengyang, 421001, China. Electronic address:

Previously we reported that recombinant Chlamydia muridarum macrophage infectivity potentiator (MIP) provided partial protection against C. muridarum genital tract infection in mice. On the other hand, Chlamydia trachomatis plasmid encoded Pgp3could induce the protection against C. Read More

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http://dx.doi.org/10.1016/j.imbio.2018.11.009DOI Listing
December 2018
3 Reads

No evidence for humoral autoimmunity against cardiomyocytes, adrenergic or muscarinic receptors in patients with Tako-Tsubo cardiomyopathy.

Immunobiology 2018 Nov 15. Epub 2018 Nov 15.

Dept. of Neurology, Justus Liebig University, Klinikstrasse 33, Giessen, Germany; Dept. of Neurology, Gesundheitszentrum Wetterau, Chaumontplatz 1, Bad Nauheim, Germany. Electronic address:

Background: An association between Tako-Tsubo cardiomyopathy (TTC) and underlying malignancies has been observed, suggesting that TTC might be the consequence of paraneoplastic phenomena. This study investigates the presence of autoantibodies against cardiomyocytes as well as adrenergic (β, β) and muscarinic (M2) receptors in patients with TTC.

Methods And Results: Serum from 20 TTC patients and 20 controls with ischemic heart disease was obtained. Read More

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http://dx.doi.org/10.1016/j.imbio.2018.11.005DOI Listing
November 2018
3 Reads

Myeloid and lymphoid activation markers in AIDS and non-AIDS presenters.

Immunobiology 2018 Nov 28. Epub 2018 Nov 28.

Department of Public Health and Infectious Diseases, Sapienza University, Piazzale Aldo Moro 5, 00185, Rome, Italy; Infectious Diseases Unit, Sapienza University, Santa Maria Goretti Hospital, Via Canova, 04100, Latina, Italy.

HIV infection is characterized by a state of chronic activation of the immune system, which is not completely reversed by antiretroviral treatment (ART). The aim of this study was to assess myeloid and lymphoid activation markers during HIV infection, before and one year after ART initiation, in AIDS and non-AIDS presenters. Treatment naïve HIV positive patients were enrolled in this study. Read More

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http://dx.doi.org/10.1016/j.imbio.2018.11.011DOI Listing
November 2018
4 Reads

High frequency of macrophages expressing elevated level of CD80, PD-Ls and TLR1 in nasal polyps of CRS patients.

Immunobiology 2019 Jan 21;224(1):154-162. Epub 2018 Oct 21.

Department of Immunology, University of Medical Sciences in Poznan, Poland
.

Identification of the association between tissue biomarkers, their surrogates in blood and clinical features, could provide new diagnostic tools and facilitate adequate choices of therapeutic interventions for selected patients suffering from CRS. The aim of present study was the assessment of macrophages in the polyp tissue and monocytes in the peripheral blood in the course of CRSwNP, and their functional immunophenotype. We analyzed 31 patients with CRSwNP. Read More

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http://dx.doi.org/10.1016/j.imbio.2018.09.004DOI Listing
January 2019
1 Read

The rs1805193, rs5361, and rs5355 single nucleotide polymorphisms in the E-selectin gene (SEL-E) are associated with subclinical atherosclerosis: The Genetics of Atherosclerotic Disease (GEA) Mexican study.

Immunobiology 2019 Jan 24;224(1):10-14. Epub 2018 Nov 24.

Department of Molecular Biology, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City, Mexico. Electronic address:

The aim of this study was to evaluate the association of rs1805193, rs5361, and rs5355 E-selectin gene single nucleotide polymorphisms (SNPs) with the risk of developing subclinical atherosclerosis (SA) in a group of Mexicans individuals. SNPs were determined by TaqMan genotyping assays in a group of 287 individuals with SA and 688 healthy controls. Under different models, the T allele of the 5'UTR G98 T (rs1805193) (OR = 1. Read More

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http://dx.doi.org/10.1016/j.imbio.2018.11.003DOI Listing
January 2019
2 Reads

IL-13 attenuates early local CXCL2-dependent neutrophil recruitment for Candida albicans clearance during a severe murine systemic infection.

Immunobiology 2019 Jan 24;224(1):15-29. Epub 2018 Nov 24.

Department of Infection Control, Fukushima Medical University, Hikarigaoka, Fukushima, 960-1295, Japan.

To investigate the role of IL-13 during a severe systemic Candida albicans infection, BALB/c control and IL-13 mice were examined for colony forming units (CFU) in the kidneys and survival days after intravenous infection. Proinflammatory mediators and cell recruitment into the tissue were measured by quantitative real-time PCR, a multiple ELISA system, and morphological cell differentiation. The IL-13 group exhibited a lower CFU number in the kidneys at 4 days and survived longer than the control mice, which was accompanied by significantly higher expression of C-X-C motif ligand 2 (CXCL2), IFN-γ, and polymorphonuclear neutrophils (PMNs) in the infected kidneys. Read More

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http://dx.doi.org/10.1016/j.imbio.2018.11.002DOI Listing
January 2019
2 Reads

Inherent allergic potential of α-dioxygenase fragment: A pathogenesis related protein.

Immunobiology 2018 Nov 15. Epub 2018 Nov 15.

Food Toxicology Laboratory, Food, Drug and Chemical Toxicology Group, CSIR-Indian Institute of Toxicology Research (CSIR-IITR), Vishvigyan Bhawan, 31, Mahatma Gandhi Marg, Lucknow, 226 001, Uttar Pradesh, India; Academy of Scientific and Innovative Research (AcSIR), CSIR-IITR campus Lucknow, India. Electronic address:

In the course of analyzing amino acid sequence of an allergen (≈20 kDa), we found this protein has a homology with the amino acid sequence of putative α-Dioxygenase fragment (ADF). Allergy caused by many allergens having an enzymatic activity have been reported previously, but allergenicity to neither α-Dioxygenase enzyme nor to it's any constituents has been reported. We sought to purify an ADF (≈19. Read More

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http://dx.doi.org/10.1016/j.imbio.2018.11.006DOI Listing
November 2018
11 Reads
3.044 Impact Factor

Anti-inflammatory activity of small-molecule antagonists of Toll-like receptor 2 (TLR2) in mice.

Immunobiology 2019 Jan 20;224(1):1-9. Epub 2018 Nov 20.

Section of Biochemical Pharmacology, Medical University of Innsbruck, A-6020, Innsbruck, Austria. Electronic address:

Toll-like receptor 2 (TLR2) is currently investigated as a potential therapeutic target in diseases with underlying inflammation like sepsis and arthritis. We reported the discovery, by virtual screening and biological testing, of eight TLR2 antagonists (AT1-AT8) which showed TLR2-inhibitory activity in human cells (Murgueitio et al., 2014). Read More

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http://dx.doi.org/10.1016/j.imbio.2018.11.004DOI Listing
January 2019
2 Reads

C-type lectin 17A and macrophage-expressed receptor genes are magnified by fungal β-glucan after Vibrio parahaemolyticus infection in Totoaba macdonaldi cells.

Immunobiology 2019 Jan 18;224(1):102-109. Epub 2018 Oct 18.

Immunology & Vaccinology Group, Centro de Investigaciones Biológicas del Noroeste (CIBNOR), Av. Instituto Politécnico Nacional 195, Playa Palo de Santa Rita Sur, La Paz, B.C.S, 23096, Mexico. Electronic address:

C-type lectins are a principal carbohydrate recognition mechanism as glucans on cell surfaces. This study identified and investigated molecular characterization and immune roles of a novel c-type lectin 17A from Totoaba macdonaldi (TmCLEC17A), which were described in head-kidney leukocytes after immunostimulation with fungal β-glucan 197A and Vibrio parahaemolyticus infection. This nucleotide sequence from totoaba was acquired using NGS and bioinformatics tools. Read More

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http://dx.doi.org/10.1016/j.imbio.2018.10.003DOI Listing
January 2019
2 Reads

SNPs in 3'-UTR region of MBL2 increases susceptibility to recurrent vulvovaginal infections by altering sMBL levels.

Immunobiology 2019 Jan 20;224(1):42-49. Epub 2018 Nov 20.

Department of Human Genetics, Guru Nanak Dev University, Amritsar, India. Electronic address:

Recurrent vulvovaginal infections (RVVI), owing to their adverse health consequences, have become a serious dilemma worldwide. Low serum levels of Mannose-Binding Lectin (sMBL), a main component of innate immunity, was found to be associated with RVVI risk, though complete genetic bases are still elusive. To reveal unrecognised regulatory variants, 3'-UTR region of MBL2 with six putative functional SNPs i. Read More

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http://dx.doi.org/10.1016/j.imbio.2018.10.009DOI Listing
January 2019
5 Reads
3.044 Impact Factor

CPAF, HSP60 and MOMP antigens elicit pro-inflammatory cytokines production in the peripheral blood mononuclear cells from genital Chlamydia trachomatis-infected patients.

Immunobiology 2019 Jan 20;224(1):34-41. Epub 2018 Nov 20.

Department of Medical Microbiology, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia; Tropical Infectious Disease Research and Education Center, University of Malaya, 50603 Kuala Lumpur, Malaysia.

Background: Persistent inflammation caused by Chlamydia trachomatis in the female genital compartment represents one of the major causes of pelvic inflammatory disease (PID), ectopic pregnancy and infertility in females. Here, we examined the pro-inflammatory cytokine response following stimulation with three different types of C. trachomatis antigens, viz. Read More

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http://dx.doi.org/10.1016/j.imbio.2018.10.010DOI Listing
January 2019
4 Reads

Unravelling the apoptotic mechanisms in T-lymphocytes in an animal model for pollen induced airway allergy and studying the impact of specific immunotherapy.

Immunobiology 2018 Nov 16. Epub 2018 Nov 16.

Department of Laboratory Medicine, School of Tropical Medicine, 108 C. R. Avenue, Kolkata, 700073, West Bengal, India. Electronic address:

Asthma is a chronic inflammatory disorder of the airways, increasing in prevalence worldwide. Reduced T cell apoptosis may interfere with the down-regulation of an immune response resulting in T cell accumulation contributing to the chronic inflammation of asthma. Most studies focused so far on apoptosis of eosinophils but the detailed role of T lymphocytes apoptosis in allergic diseases is unclear yet. Read More

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http://dx.doi.org/10.1016/j.imbio.2018.11.008DOI Listing
November 2018
8 Reads
3.044 Impact Factor

Comparative analysis of expression of microbial sensing molecules in mucosal tissues with periodontal disease.

Immunobiology 2018 Nov 15. Epub 2018 Nov 15.

Center for Oral Health Research, University of Kentucky, Lexington, KY, United States; Division of Periodontics, College of Dentistry, University of Kentucky, Lexington, KY, United States.

Host-derived pattern recognition receptors (PRRs) are necessary for effective innate immune engagement of pathogens that express microbial-associated molecular patterns (MAMP) ligands for these PRRs. This study used a nonhuman primate model to evaluate the expression of these sensing molecules in gingival tissues. Macaca mulatta aged 12-24 with a healthy periodontium (n = 13) or periodontitis (n = 11) provided gingival tissues for assessment of naturally-occurring periodontitis. Read More

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http://dx.doi.org/10.1016/j.imbio.2018.11.007DOI Listing
November 2018
14 Reads

Basophil activation test in children with autoimmune chronic spontaneous urticaria: Is it ready for clinical practice?

Immunobiology 2019 Jan 13;224(1):30-33. Epub 2018 Nov 13.

Department of Pediatrics, Foundation IRCCS Policlinico San Matteo, Pavia, Italy.

Introduction: Chronic spontaneous urticaria (CSU) is characterized by recurrent itchy wheals, angioedema or both, that persist for longer than six weeks. In children, up to 40% of chronic spontaneous urticaria is due to mast cells and basophils-activating autoantibodies, mostly directed against the IgE high-affinity receptor subunit (FcεRI). Indirect basophil activation test (BAT) has been proposed in the diagnosis of autoimmune urticaria. Read More

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http://dx.doi.org/10.1016/j.imbio.2018.11.001DOI Listing
January 2019
10 Reads

PACAP deficiency aggravates atherosclerosis in ApoE deficient mice.

Immunobiology 2019 Jan 26;224(1):124-132. Epub 2018 Oct 26.

Department of Medical Cell Biology, Institute for Anatomy and Cell Biology, Medical Faculty, Philipps-University of Marburg, Robert-Koch-Str. 8, 35037 Marburg, Germany.

Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP) plays an important role in cytoprotection, inflammation and cardiovascular regulation. Thus, we studied the involvement of PACAP in atherogenesis. Differentiated human THP-1 macrophages (MΦ) were stimulated with oxidized low-density lipoproteins (oxLDL) and the influence of PACAP38 treatment on lipid content and TNF release was determined. Read More

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http://dx.doi.org/10.1016/j.imbio.2018.09.008DOI Listing
January 2019
11 Reads

PHA eludes macrophage suppression to activate CD8 T cells.

Immunobiology 2019 Jan 3;224(1):94-101. Epub 2018 Nov 3.

Biology Department, Rider University, Lawrenceville, New Jersey, United States. Electronic address:

Tumors may include a high proportion of immune modulatory cells and molecules that restrain the anti-cancer response. Activation of T cells to eliminate cancer cells within the immune-suppressive tumor microenvironment remains a challenge. We have shown that C57BL/6 J peritoneal cell culture models features of macrophage-dense tumors as TCR ligation fails to activate T cells unless IFNγ is neutralized or iNOS is inhibited. Read More

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http://dx.doi.org/10.1016/j.imbio.2018.10.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6387856PMC
January 2019
11 Reads

Celiac disease-specific and inflammatory bowel disease-related antibodies in patients with recurrent aphthous stomatitis.

Immunobiology 2019 Jan 2;224(1):75-79. Epub 2018 Nov 2.

Clinic of Allergy and Clinical Immunology, Clinical Center of Serbia, Koste Todorovica 2, Belgrade 11000, Serbia.

The etiology of recurrent aphthous stomatitis (RAS) remains unknown. RAS can be presented as primary, idiopathic condition and as a secondary RAS, which is associated with a systemic disease. The aim of our study was to evaluate the presence and concentrations of antibodies specific for celiac disease (CeD) and antibodies related to inflammatory bowel diseases (IBD) in patients with RAS without gastrointestinal symptoms. Read More

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http://dx.doi.org/10.1016/j.imbio.2018.10.006DOI Listing
January 2019
14 Reads

Increased central adiposity is associated with pro-inflammatory immunoglobulin G N-glycans.

Immunobiology 2019 Jan 19;224(1):110-115. Epub 2018 Oct 19.

School of Medical and Health Sciences, Edith Cowan University, Joondalup, 6027, Australia; Key Municipal Laboratory of Clinical Epidemiology, Capital Medical University, Beijing, 100069, China; Taishan Medical University, Taian, 271016, China. Electronic address:

Background: Increased body fat may be associated with an increased risk of developing an underlying pro-inflammatory state, thus leading to greater risk of developing certain chronic conditions. Immunoglobulin G has the ability to exert both anti- and pro-inflammatory effects, and the N-glycosylation of the fragment crystallisable portion is involved in mediating this process. Body mass index, a rudimentary yet gold standard indication for body fat, has been shown to be associated with agalactosylated immunoglobulin G N-glycans. Read More

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http://dx.doi.org/10.1016/j.imbio.2018.10.002DOI Listing
January 2019
8 Reads

P2X7 receptor-mediated leukocyte recruitment and Porphyromonas gingivalis clearance requires IL-1β production and autocrine IL-1 receptor activation.

Immunobiology 2019 Jan 2;224(1):50-59. Epub 2018 Nov 2.

Immunobiology Program, Institute of Biophysics Carlos Chagas Filho, Federal University of Rio de Janeiro, Rio de Janeiro, RJ, 21941-902 Brazil. Electronic address:

The Gram-negative bacterium Porphyromonas gingivalis is strongly associated with periodontitis. We previously demonstrated that P2X7 receptor activation by extracellular ATP (eATP) triggers elimination of intracellular pathogens, such as Leishmania amazonensis, Toxoplasma gondii and Chlamydia trachomatis. We also showed that eATP-induced IL-1β secretion via the P2X7 receptor is impaired by P. Read More

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http://dx.doi.org/10.1016/j.imbio.2018.10.008DOI Listing
January 2019
11 Reads

Granulocyte macrophage-colony stimulating factor: A key modulator of renal mononuclear phagocyte plasticity.

Immunobiology 2019 Jan 2;224(1):60-74. Epub 2018 Nov 2.

The University of Edinburgh/ Centre for Inflammation Research, The Queen's Medical Research Institute, Edinburgh BioQuarter, 47 Little France Crescent Edinburgh EH16 4TJ, Scotland, United Kingdom.

Macrophage-colony stimulating factor (M-CSF) and granulocyte macrophage-colony stimulating factor (GM-CSF) play key roles in the differentiation of macrophages and dendritic cells (DCs). We examined the effect of treatment with M-CSF-containing macrophage medium or GM-CSF-containing DC medium upon the phenotype of murine bone marrow-derived macrophages and DCs. Culture of macrophages for 5 days in DC medium reduced F4/80 expression and increased CD11c expression with cells effectively stimulating T cell proliferation in a mixed lymphocyte reaction. Read More

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January 2019
4 Reads

Effect of Trichinella spiralis intervention on TNBS-induced experimental colitis in mice.

Immunobiology 2019 Jan 25;224(1):147-153. Epub 2018 Oct 25.

Heilongjiang Key Laboratory for Animal Disease Control and Pharmaceutical Development, College of Veterinary Medicine, Northeast Agricultural University, 600 Changjiang Street, Harbin 150030, China. Electronic address:

Inflammatory bowel disease (IBD), including ulcerative colitis and Crohn's disease (CD), are chronic autoimmune diseases with a high recurrence rate. Epidemiological data have shown that the incidence of IBD increases annually because of improved sanitary conditions and reduced parasitic infection rates. In this experiment, experimental colitis was induced in mice by administering 2,4,6-trinitrobenzene sulfonic acid (TNBS) 28 days after they were infected with Trichinella spiralis to confirm that T. Read More

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http://dx.doi.org/10.1016/j.imbio.2018.09.005DOI Listing
January 2019
14 Reads

Activation of human macrophage sodium channels regulates RNA processing to increase expression of the DNA repair protein PPP1R10.

Immunobiology 2019 Jan 24;224(1):80-93. Epub 2018 Oct 24.

Department of Neurology, University of Illinois College of Medicine, Chicago, IL 60612, United States; Program in Neuroscience, University of Illinois College of Medicine, Chicago, IL 60612, United States; Jesse Brown Veterans Affairs Medical Center, Chicago, IL 60612, United States. Electronic address:

Prior work demonstrated that a splice variant of SCN5A, a voltage-gated sodium channel gene, acts as a cytoplasmic sensor for viral dsRNA in human macrophages. Expression of this channel also polarizes macrophages to an anti-inflammatory phenotype in vitro and in vivo. Here we utilized global expression analysis of splice variants to identify novel channel-dependent signaling mechanisms. Read More

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http://dx.doi.org/10.1016/j.imbio.2018.10.005DOI Listing
January 2019
12 Reads

Duration dependent effect of chronic stress on primary and secondary lymphoid organs and their reversibility in rats.

Immunobiology 2019 Jan 28;224(1):133-141. Epub 2018 Sep 28.

Department of Zoology, University of Mysore, Manasagangotri, Mysore, 570 006, India. Electronic address:

The present study was undertaken to investigate whether or not chronic stress effect and its reversibility on lymphoid organs is duration dependent. Male rats were exposed to restraint (1 h) followed by a gap of 4 h to forced swimming exercise (15 min) daily for 2, 4 and 8 weeks. After each exposure period, rats were allowed to recover for 6 weeks. Read More

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http://dx.doi.org/10.1016/j.imbio.2018.09.007DOI Listing
January 2019
11 Reads

Pulmonary Aspergillus fumigatus infection in rats affects gastrointestinal homeostasis.

Immunobiology 2019 Jan 13;224(1):116-123. Epub 2018 Oct 13.

Immunotoxicology Group, Department of Ecology, Institute for Biological Research "Sinisa Stankovic", University of Belgrade, Bulevar despota Stefana 142, 11060, Belgrade, Serbia; Institute of Physiology and Biochemistry, Faculty of Biology, University of Belgrade, Studentski trg 16, 11000, Belgrade, Serbia. Electronic address:

Microbiota inhabiting mucosal tissues is involved in maintenance of their immune homeostasis. Growing body of evidence indicate that dysbiosis in gut influence immune responses at distal sites including lungs. There are also reports concerning gut involvement with pulmonary injury/inflammation in settings of respiratory viral and bacterial infections. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01712985183010
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http://dx.doi.org/10.1016/j.imbio.2018.10.001DOI Listing
January 2019
14 Reads

Are rats more human than mice?

Authors:
Gerhild Wildner

Immunobiology 2019 Jan 12;224(1):172-176. Epub 2018 Oct 12.

Section of Immunobiology, Department of Ophthalmology, University Hospital, LMU Munich, Germany. Electronic address:

In contrast to rats, mouse models are nowadays generally used for the investigation of immune responses and immune-mediated diseases, there are many different strains and mouse-specific tools available, and it is easy to generate transgenic and constitutive or inducible knockout mice for any gene. Many immune markers and mechanisms have been detected in mice and have been introduced as gold standard in immunology, however, some turned out to be not unconditionally transferable to the human immune system. Rats have been used more frequently in former days but are mostly outstripped by mice due to the fact that fewer strains are available, they need more space than mice, are more expensive to maintain and breed, and it is extremely difficult to generate transgenic or ko-rats. Read More

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http://dx.doi.org/10.1016/j.imbio.2018.09.002DOI Listing
January 2019
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The role of inhibitor of binding or differentiation 2 in the development and differentiation of immune cells.

Immunobiology 2019 Jan 20;224(1):142-146. Epub 2018 Sep 20.

Reproductive Sciences Institute of Jiangsu University, Zhenjiang 212001, Jiangsu, P.R. China; Department of Immunology, Key Laboratory of Medical Science and Laboratory Medicine of Jiangsu Province, School of Medicine, Jiangsu University, Zhenjiang 212013, Jiangsu, P.R. China. Electronic address:

Inhibitor of binding or differentiation 2 (Id2), a member of helix-loop-helix (HLH) transcriptional factors, is recently reported as an important regulator of the development or differentiation of immune cells. It has been demonstrated that Id2 plays a critical role in the early lymphopoiesis. However, it has been discovered recently that Id2 displays new functions in different immune cells. Read More

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http://dx.doi.org/10.1016/j.imbio.2018.09.006DOI Listing
January 2019
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A trypsin-based method for isolating leukocytes from human choriodecidua suitable for immunophenotyping and transcriptome studies.

Immunobiology 2019 Jan 22;224(1):177-181. Epub 2018 Sep 22.

Departamento de Nutrición y Bioprogramación, Instituto Nacional de Perinatología Isidro Espinosa de los Reyes, Montes Urales 800, Lomas Virreyes, 11000 Mexico City, Mexico. Electronic address:

Leukocytes found at the human maternal-fetal interface participate in the inflammatory process associated with both preterm and term labor; therein, effective methods for their isolation that allow further phenotypic and functional analyses are necessary. Leukocyte isolation is usually carried out through scraping or enzyme digestion of the choriodecidua, however both methods usually limit the use of downstream immunophenotyping or transcriptomic techniques. Here we describe an isolation method based on gentle trypsin digestion that yields a leukocyte-enriched cell mixture with high lymphocyte viability, although less viable myeloid cells. Read More

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http://dx.doi.org/10.1016/j.imbio.2018.09.001DOI Listing
January 2019
1 Read