459,544 results match your criteria Immunity & Ageing [Journal]


E3 ligase ASB8 promotes porcine reproductive and respiratory syndrome virus proliferation by stabilizing the viral Nsp1α protein and degrading host IKKβ kinase.

Virology 2019 Apr 15;532:55-68. Epub 2019 Apr 15.

School of Life Sciences, Tianjin University, Tianjin, 300072, China. Electronic address:

Porcine reproductive and respiratory syndrome virus (PRRSV) can potently suppress type I interferon production and escape from innate immune responses. PRRSV nonstructural protein 1α (Nsp1α) can inhibit IFN-β and NF-κB gene promoter activities, but the precise mechanisms are largely unclear. In this study, we demonstrated that PRRSV Nsp1α interacted with the host E3 ubiquitin ligase ankyrin repeat and SOCS box-containing 8 (ASB8). Read More

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http://dx.doi.org/10.1016/j.virol.2019.04.004DOI Listing

Identification and bioactivity of a granulocyte colony-stimulating factor b homologue from large yellow croaker (Larimichthys crocea).

Fish Shellfish Immunol 2019 Apr 19. Epub 2019 Apr 19.

Key Laboratory of Marine Biogenetic Resources, Third Institute of Oceanography, State Oceanic Administration, Xiamen, 361005, China; Laboratory for Marine Biology and Biotechnology, Qingdao National Laboratory for Marine Science and Technology, Qingdao, 266071, China; Key Laboratory of Marine Biotechnology of Fujian Province, Institute of Oceanology, Fujian Agriculture and Forestry University, Fuzhou, 350002, China. Electronic address:

Granulocyte colony-stimulating factor (GCSF) is a pleiotropic cytokine that plays a key role in regulation of hematopoiesis, innate and adaptive immune responses in mammals. However, bioactivity of GCSF in teleost fish remains largely unknown. In this study, a GCSFb homologue from large yellow croaker (Larimichthys crocea) (LcGCSFb) was cloned by RACE-PCR techniques. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10504648193028
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http://dx.doi.org/10.1016/j.fsi.2019.04.048DOI Listing
April 2019
2 Reads

Two paternal mosaicism of mutation in ELANE causing severe congenital neutropenia exhibit normal neutrophil morphology and ROS production.

Clin Immunol 2019 Apr 19. Epub 2019 Apr 19.

Chong Qing Key Laboratory of Child Infection and Immunity, Children's Hospital of Chongqing Medical University, Chongqing 400014, China; Division of Immunology, Children's Hospital of Chongqing Medical University, Chongqing 400014, China; Ministry of Education Key Laboratory of Child Development and Disorders, Key Laboratory of Pediatrics in Chongqing, Chongqing International Science and Technology Cooperation Center for Child Development and Disorders, Children's Hospital of Chongqing Medical University, Chongqing 400014, China. Electronic address:

Severe congenital neutropenia caused by ELANE gene mutation is a rare disease. To date, only four families were reported with mosaicism. Here we examined the morphology and function of granulocytes isolated from two patients and their mosaic fathers. Read More

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http://dx.doi.org/10.1016/j.clim.2019.04.008DOI Listing

Extent of Ischemic Brain Injury After Thrombotic Stroke Is Independent of the NLRP3 (NACHT, LRR and PYD Domains-Containing Protein 3) Inflammasome.

Stroke 2019 May;50(5):1232-1239

From the Division of Neuroscience and Experimental Psychology (E.L., J.B., G.C., S.M.A., D.B.), School of Biological Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, University of Manchester, United Kingdom.

Background and Purpose- A major process contributing to cell death in the ischemic brain is inflammation. Inflammasomes are multimolecular protein complexes that drive inflammation through activation of proinflammatory cytokines, such as IL (interleukin)-1β. Preclinical evidence suggests that IL-1β contributes to a worsening of ischemic brain injury. Read More

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http://dx.doi.org/10.1161/STROKEAHA.118.023620DOI Listing

Targeting Peroxisome Proliferator-Activated Receptor-Gamma Decreases Host Mortality After Influenza Infection in Obese Mice.

Viral Immunol 2019 Apr 19. Epub 2019 Apr 19.

1 Thoracic Diseases Research Unit, Division of Pulmonary and Critical Care Medicine, Department of Medicine, Mayo Clinic College of Medicine and Science, Rochester, Minnesota.

Obesity is an independent risk factor for severe influenza infection. However, the underlying cellular and molecular mechanisms are still incompletely understood. In this study, we have utilized a murine influenza infection model in genetic-induced obese (db/db) mice to explore the mechanisms by which obesity increases host susceptibility to influenza infection. Read More

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https://www.liebertpub.com/doi/10.1089/vim.2019.0016
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http://dx.doi.org/10.1089/vim.2019.0016DOI Listing
April 2019
1 Read

Selection of adjuvants for vaccines targeting specific pathogens.

Expert Rev Vaccines 2019 Apr 22:1-17. Epub 2019 Apr 22.

a VIDO-InterVac , University of Saskatchewan , Saskatoon , Canada.

Introduction: Adjuvants form an integral component in most of the inactivated and subunit vaccine formulations. Careful and proper selection of adjuvants helps in promoting appropriate immune responses against target pathogens at both innate and adaptive levels such that protective immunity can be elicited. Areas covered: Herein, we describe the recent progress in our understanding of the mode of action of adjuvants that are licensed for use in human vaccines or in clinical or pre-clinical stages at both innate and adaptive levels. Read More

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http://dx.doi.org/10.1080/14760584.2019.1604231DOI Listing

Exon 2 Skipping Eliminates Gamma-Glutamyl Carboxylase Activity, Indicating a Partial Splicing Defect in a Patient with Vitamin K Clotting Factor Deficiency.

J Thromb Haemost 2019 Apr 22. Epub 2019 Apr 22.

Departments of Cardiovascular, Lerner Research Institute, Cleveland Clinic Lerner College of Medicine at CWRU, Cleveland Clinic, 9500 Euclid Avenue NB50, Cleveland, OH, 44195.

Background: Mutations in the gamma-glutamyl carboxylase (GGCX), which is required for vitamin K-dependent (VKD) protein activation, can result in vitamin K clotting factor deficiency (VKCFD1). A recent report described a VKCFD1 patient with a homozygous carboxylase mutation that altered splicing and deleted exon 2 (Δ2GGCX). Only Δ2GGCX RNA was observed in the patient. Read More

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http://dx.doi.org/10.1111/jth.14456DOI Listing

Chimeric antigen receptor T cell persistence and memory cell formation.

Immunol Cell Biol 2019 Apr 22. Epub 2019 Apr 22.

Dept. Microbiology and Immunology, University of Otago, Dunedin, 9054, New Zealand.

It is now becoming clear that less differentiated naive and memory T cells are superior to effector T cells in the transfer of immunity for adoptive cell therapy. This review will outline the challenges faced by CAR T cell therapy in the generation of persistence and memory for CAR T cells, and summarise recent strategies to improve CAR T cell persistence, with a focus on memory cell formation. The relevance of enhancing persistence in more differentiated effector T cells is also covered, because genetic and pharmacological interventions may prolong effector T cell activity and lifespan, thereby improving anti-cancer activity. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/imcb.12254
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http://dx.doi.org/10.1111/imcb.12254DOI Listing
April 2019
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Multivariate analyses reveal biological components related to neuronal signaling and immunity mediating EEG abnormalities in alcohol-dependent individuals from the COGA cohort.

Alcohol Clin Exp Res 2019 Apr 22. Epub 2019 Apr 22.

Olin Neuropsychiatry Research Center, Hartford Hospital/IOL, Hartford, CT, 06107.

Background: The underlying molecular mechanisms associated with alcohol use disorder (AUD) risk have only been partially revealed using traditional approaches such as univariate GWAS and linkage-based analyses. We therefore aimed to identify gene clusters related to EEG neurobiological phenotypes distinctive to individuals with AUD using a multivariate approach.

Methods: The current project adopted a bi-multivariate data-driven approach, parallel independent component analysis (para-ICA) to derive and explore significant genotype-phenotype associations in a case-control subset of the Collaborative Study on the Genetics of Alcoholism (COGA) dataset. Read More

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http://dx.doi.org/10.1111/acer.14063DOI Listing

Novel Role of Macrophage Migration Inhibitory Factor in Upstream Control of the Unfolded Protein Response after Ethanol Feeding in Mice.

Alcohol Clin Exp Res 2019 Apr 22. Epub 2019 Apr 22.

Center for Liver Disease Research, Department of Inflammation and Immunity - Cleveland Clinic, Cleveland, OH, United States.

Introduction: Macrophage migration inhibitory factor (MIF), a pluripotent immune regulator, is an emerging mediator in Alcohol-related Liver Disease (ALD). MIF is associated with ALD progression through its chemokine- and cytokine-like activities.

Methods: Mechanistic studies into the role of MIF in ethanol-induced liver injury were performed in Mif mice and in C57BL/6J mice treated with a small molecule MIF antagonist, MIF098, after Gao-Binge (acute-on-chronic) ethanol feeding, an ethanol feeding protocol associated with hepatic neutrophilia and induction of the Unfolded Protein Response (UPR). Read More

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http://dx.doi.org/10.1111/acer.14065DOI Listing

Controlling Measles through Politics and Policy.

Authors:
Ross D Silverman

Hastings Cent Rep 2019 Apr 22. Epub 2019 Apr 22.

Vaccination is one of history's most successful public health interventions. Since 2000, vaccination campaigns against measles, which is highly contagious but preventable through the measles-mumps-rubella (MMR) vaccine, have reduced both the global incidence of the disease and measles deaths by 80 percent. However, progress toward measles elimination has slid backward in several previously well-protected global regions. Read More

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http://dx.doi.org/10.1002/hast.996DOI Listing

Homozygous stop mutation in AHR causes autosomal recessive foveal hypoplasia and infantile nystagmus.

Brain 2019 Apr 22. Epub 2019 Apr 22.

Molecular Genetics Laboratory, Institute for Ophthalmic Research, University of Tuebingen, Tuebingen, Germany.

Herein we present a consanguineous family with three children affected by foveal hypoplasia with infantile nystagmus, following an autosomal recessive mode of inheritance. The patients showed normal electroretinography responses, no signs of albinism, and no anterior segment or brain abnormalities. Upon whole exome sequencing, we identified a homozygous mutation (c. Read More

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https://academic.oup.com/brain/advance-article/doi/10.1093/b
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http://dx.doi.org/10.1093/brain/awz098DOI Listing
April 2019
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Duration of Immunity and Effectiveness of Diphtheria-Tetanus-Acellular Pertussis Vaccines in Children.

JAMA Pediatr 2019 Apr 22. Epub 2019 Apr 22.

Department of Ecology and Evolutionary Biology, University of Michigan, Ann Arbor.

Importance: The United States has experienced a nationwide resurgence of pertussis since the mid-1970s, despite high estimated vaccine coverage. Short-lived immunity induced by diphtheria-tetanus-acellular pertussis (DTaP) vaccines in young children is widely believed to be responsible for this growing burden, but the duration of protection conferred by DTaP vaccines remains incompletely quantified.

Objective: To assess the duration of immunity and the effectiveness of DTaP vaccines in US children. Read More

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http://dx.doi.org/10.1001/jamapediatrics.2019.0711DOI Listing

Altered Monocyte and NK Cell Phenotypes Correlate with Post-Trauma Infection.

J Trauma Acute Care Surg 2019 Apr 18. Epub 2019 Apr 18.

75 Francis St. Boston, MA.

Background: Trauma induces a complex immune response, requiring a systems biology approach to capture multicellular changes. Using mass cytometry by time-of-flight (CyTOF), we evaluated time-dependent changes in peripheral blood in trauma patients to identify changes correlated with infection.

Methods: Total leukocytes were prepared via red blood cell lysis using peripheral blood samples from trauma patients with an injury severity score > 20 at days 1, 3, and 5 after injury, and from age- and gender-matched uninjured controls. Read More

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http://dx.doi.org/10.1097/TA.0000000000002264DOI Listing

Identification of novel Adenosine Deaminase 2 gene variants and varied clinical phenotype in pediatric vasculitis.

Arthritis Rheumatol 2019 Apr 22. Epub 2019 Apr 22.

BC Children's Hospital Research Institute, BC Children's Hospital, Vancouver, BC, Canada.

Objectives: Individuals with deficiency of adenosine deaminase 2 (DADA2), a recently recognized autosomal recessive disease, present with various systemic vascular and inflammatory manifestations, often with early-onset age, or recurrent strokes. Their clinical features and histological findings overlap with those of childhood onset polyarteritis nodosa (PAN), a primary "idiopathic" systemic vasculitis. Despite similar clinical presentation, individuals with DADA2 may respond better to biologic therapy than traditional immunosuppression. Read More

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http://dx.doi.org/10.1002/art.40913DOI Listing

[Cancer pain, a serious threat to patientsmemory].

Sheng Li Xue Bao 2019 Apr;71(2):343-349

Scientific Research Management Department, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Chongming Branch, Shanghai 202150, China.

A large number of cancer patients suffer from pain. Growing evidence suggested that pain might be a serious risk factor for cancer patients. The shared modulators and modulation pathways between neural system and tumor cells, such as various neurotransmitters and neurogenic cytokines, provide essential basis for the effect of pain on tumor. Read More

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Ovarian Cancer Stem Cells with High ROR1 Expression Serve as a New Prophylactic Vaccine for Ovarian Cancer.

J Immunol Res 2019 17;2019:9394615. Epub 2019 Mar 17.

Department of Pathogenic Biology and Immunology of Medical School, Southeast University, Nanjing 210009, China.

Tumor vaccines offer a number of advantages for cancer treatment. In the study, the vaccination with cancer stem cells (CSCs) with high expression of the type I receptor tyrosine kinase-like orphan receptor (ROR1) was evaluated in a murine model for the vaccine's immunogenicity and protective efficacy against epithelial ovarian carcinoma (EOC). CD117CD44 CSCs were isolated from human EOC HO8910 cell line using a magnetic-activated cell sorting system; murine ID8 EOC suspension sphere cells, which are collectively known as cancer stem-like cells, were acquired from serum-free suspension sphere-forming culture. Read More

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http://dx.doi.org/10.1155/2019/9394615DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6441513PMC

Correction: HOTAIR regulates HK2 expression by binding endogenous miR-125 and miR-143 in oesophageal squamous cell carcinoma progression.

Oncotarget 2019 Mar 12;10(21):2112. Epub 2019 Mar 12.

Department of Surgical Oncology, Nanjing First Hospital, Nanjing Medical University, Nanjing 210008, Jiangsu Province, China.

[This corrects the article DOI: 10.18632/oncotarget.21195. Read More

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http://dx.doi.org/10.18632/oncotarget.26801DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6459342PMC

New evolving strategies revealed by transcriptomic analysis of a fur mutant of the cyanotrophic bacterium Pseudomonas pseudoalcaligenes CECT 5344.

Microb Biotechnol 2019 Apr 21. Epub 2019 Apr 21.

Departamento de Bioquímica y Biología Molecular y Genética, Facultad de Veterinaria, Universidad de Extremadura, Caceres, Spain.

The transcriptomic analysis (RNA-seq) of a fur mutant of P. pseudoalcaligenes CECT 5344 has revealed that Fur regulates the expression of more than 100 genes in this bacterial strain, most of them negatively. The highest upregulated genes in response to fur deletion, with respect to the wild type, both cultivated in LB medium, corresponded to genes implicated in iron uptake. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/1751-7915.13
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http://dx.doi.org/10.1111/1751-7915.13408DOI Listing
April 2019
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Neonatal Vitamin A Supplementation and Vitamin A Status Are Associated with Gut Microbiome Composition in Bangladeshi Infants in Early Infancy and at 2 Years of Age.

J Nutr 2019 Apr 22. Epub 2019 Apr 22.

Nutrition Department.

Background: Infancy is a crucial period for establishing the intestinal microbiome. This process may be influenced by vitamin A (VA) status because VA affects intestinal immunity and epithelial integrity, factors that can, in turn, modulate microbiome development.

Objectives: The aim of this study was to determine if neonatal VA supplementation (VAS) affected the abundance of Bifidobacterium, a beneficial commensal, or of Proteobacteria, a phylum containing enteric pathogens, in early (6-15 wk) or late (2 y) infancy. Read More

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https://academic.oup.com/jn/advance-article/doi/10.1093/jn/n
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http://dx.doi.org/10.1093/jn/nxz034DOI Listing
April 2019
1 Read

[Methodology of the 2nd seroprevalence study in Spain].

Rev Esp Salud Publica 2019 Apr 22;93. Epub 2019 Apr 22.

Subdirección General de Promoción de la Salud y Vigilancia en Salud Pública. Dirección General de Salud Pública, Calidad e Innovación. Ministerio de Sanidad, Consumo y Bienestar Social. Madrid. España.

Seroprevalence studies are designed in population samples to assess the level and distribution of immunity induced by natural infection of certain infectious agents or by immunization against them. The purpose of the 2nd Seroprevalence Study in Spain is to assess the prevalence and distribution of immune status against vaccine-preventable diseases and generated by natural infection by other microorganisms. Pathologies specifically included in the study are: poliomyelitis, diphtheria, tetanus, pertussis, measles, rubella, mumps, varicella, invasive meningococcal disease by serogroup C, hepatitis A, hepatitis B, hepatitis E, hepatitis C and HIV. Read More

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Infiltration of CD4, CD8, CD56, and Fox-P3-positive lymphocytes in breast carcinoma tissue after neoadjuvant chemotherapy with or without trastuzumab.

Breast Dis 2019 Apr 12. Epub 2019 Apr 12.

Department of Surgery, Shiga University of Medical Science, Tsukinowa-cho, Seta, Otsu, Shiga, 520-2192, Japan.

Background: Trastuzumab (Tz) is assumed to prime antibody-dependent cellular cytotoxicity (ADCC); however, it remains unclear whether Tz therapy can clinically induce adaptive cellular immunity.

Objective: Adaptive Cellular Immune Effect of Tz Therapy.

Methods: This study included 29 surgical invasive breast carcinomas administered neoadjuvant chemotherapy with Tz (15 cases) or without Tz (14 cases). Read More

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https://www.medra.org/servlet/aliasResolver?alias=iospress&a
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http://dx.doi.org/10.3233/BD-180350DOI Listing
April 2019
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Epigenetic control of Foxp3 in intratumoral T-cells regulates growth of hepatocellular carcinoma.

Aging (Albany NY) 2019 Apr 21. Epub 2019 Apr 21.

Department of Interventional Radiology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Capability of tumor cells to impede immune response are largely associated with their interaction and regulation of CD4+CD25+ forkhead box transcription factor (Foxp)3+ regulatory T (Treg) cells, which suppress cytotoxic T cell-mediated immunity in the tumor microenvironment. Foxp3 level is critical for development and phenotypic maintenance of Treg, and is regulated by transcriptional control and epigenetic modification. Here, we showed that higher percentage of intratumoral Treg cells was positively correlated with lower Foxp3 promoter methylation in hepatocellular carcinoma (HCC), and both of them were associated with higher tumor grade, larger tumors, and poor prognosis of the patients. Read More

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http://www.aging-us.com/article/101918/text
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http://dx.doi.org/10.18632/aging.101918DOI Listing
April 2019
4 Reads

Leukocyte Adhesion: Reconceptualizing Chemokine Presentation by Glycosaminoglycans.

Trends Immunol 2019 Apr 18. Epub 2019 Apr 18.

Novimmune SA, 14 Chemin des Aulx, 1228 Plan les Ouates, Geneva, Switzerland; These authors contributed equally. Electronic address:

Recruitment of immune cells from the vasculature relies on the presentation of glycosaminoglycan-bound chemokines on the luminal side of vascular endothelial cells. However, the current model of chemokine-glycosaminoglycan interactions, and its implications for receptor interactions, remains poorly developed. We propose a refined 'Chemokine Cloud' model, arguing that chemokines are not presented to leukocytes bound to glycosaminoglycans, but rather, in solution while sequestered within the hydrated glycocalyx. Read More

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http://dx.doi.org/10.1016/j.it.2019.03.009DOI Listing

A novel role of probiotics in improving host defence of elite rugby union athlete: A double blind randomised controlled trial.

J Sci Med Sport 2019 Apr 5. Epub 2019 Apr 5.

The University of Sydney School of Pharmacy, Faculty of Medicine and Health, Australia.

Objective: To examine the effects of a probiotic protocol on the incidence and severity of respiratory and gastrointestinal infections in elite rugby union athletes across an international competition season. Associations were also investigated between salivary biomarkers of stress (cortisol, alpha-amylase) and mucosal immunity (secretory(s)-IgA).

Design: A double-blind RCT was conducted over 27-weeks, divided into three stages: (1) control period; (2) domestic competition; and (3) international competition. Read More

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http://dx.doi.org/10.1016/j.jsams.2019.03.013DOI Listing

Ubiquitin-Dependent and -Independent Roles of E3 Ligase RIPLET in Innate Immunity.

Cell 2019 Apr 16. Epub 2019 Apr 16.

Program in Virology, Division of Medical Sciences, Harvard Medical School, Boston, MA 02115, USA; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA; Program in Cellular and Molecular Medicine, Boston Children's Hospital, MA 02115, USA. Electronic address:

The conventional view posits that E3 ligases function primarily through conjugating ubiquitin (Ub) to their substrate molecules. We report here that RIPLET, an essential E3 ligase in antiviral immunity, promotes the antiviral signaling activity of the viral RNA receptor RIG-I through both Ub-dependent and -independent manners. RIPLET uses its dimeric structure and a bivalent binding mode to preferentially recognize and ubiquitinate RIG-I pre-oligomerized on dsRNA. Read More

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http://dx.doi.org/10.1016/j.cell.2019.03.017DOI Listing

Influenza and pertussis vaccination of women during pregnancy in Victoria, 2015-2017.

Med J Aust 2019 Apr 21. Epub 2019 Apr 21.

Monash University, Melbourne, VIC.

Objectives: To assess variations by time of year and hospital in the uptake of influenza and pertussis vaccinations by pregnant women in Victoria; to identify factors associated with vaccination uptake.

Design, Setting: Retrospective analysis of data in the Victorian Perinatal Data Collection (VPDC), a population surveillance system for obstetric conditions, procedures, and pregnancy and birth outcomes.

Participants: Women whose pregnancies ended in a live or stillbirth during July 2015 - June 2017. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.5694/mja2.50125
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http://dx.doi.org/10.5694/mja2.50125DOI Listing
April 2019
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MF59 adjuvant enhances the immunogenicity and protective immunity of the OmpK/Omp22 fusion protein from Acineterbacter baumannii through intratracheal inoculation in mice.

Scand J Immunol 2019 Apr 21:e12769. Epub 2019 Apr 21.

Institute of Immunology and Molecular Biology, North Sichuan Medical College, Nanchong, 637000, People's Republic of China.

Acinetobacter baumannii (A. baumannii) is an emerging nosocomial pathogenic bacterium which leads to hospital infections. The increase of drug-resistant A. Read More

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http://dx.doi.org/10.1111/sji.12769DOI Listing

Effect of metformin on the size of the HIV reservoir in non-diabetic ART-treated individuals: single-arm non-randomised Lilac pilot study protocol.

BMJ Open 2019 Apr 20;9(4):e028444. Epub 2019 Apr 20.

The Ottawa Hospital, University of Ottawa, Ottawa, Ontario, Canada.

Introduction: People living with HIV (PLWH) on antiretroviral therapy (ART) do not progress to AIDS. However, they still suffer from an increased risk of inflammation-associated complications. HIV persists in long-lived CD4+ T cells, which form the major viral reservoir. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-028444DOI Listing

Crohn's disease initiated with extraintestinal features.

BMJ Case Rep 2019 Apr 20;12(4). Epub 2019 Apr 20.

Department of Oral Health Policy and Epidemiology, Harvard School of Dental Medicine, Boston, Massachusetts, USA.

Crohn's disease (CD) is a multifactorial, chronic immune-mediated disorder. The oral cavity is involved in 0.5% to 20% of the patients with CD. Read More

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http://dx.doi.org/10.1136/bcr-2019-229916DOI Listing
April 2019
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Draft genome sequence of Enterococcus faecium E86, a producing strain of broad- -spectrum antimicrobial peptides: description of a novel bacteriocin immunity protein and a novel MLST type.

J Glob Antimicrob Resist 2019 Apr 18. Epub 2019 Apr 18.

Departamento de Microbiologia Geral, Instituto de Microbiologia Paulo de Góes, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brasil. Electronic address:

Objectives: The aim of this study is to report the draft genome sequence of the bacteriocinogenic strain Enterococcus faecium E86. Bacteriocins are prokaryotic peptides or proteins with antimicrobial activity. The genome information may then contribute to the identification of the enterocins produced by this strain that exhibits inhibitory activity against the foodborne pathogen Listeria monocytogenes and vancomycin-resistant enterococci (VRE) involved in human infections, among other bacterial genera and species. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S22137165193009
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http://dx.doi.org/10.1016/j.jgar.2019.04.004DOI Listing
April 2019
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3D type I collagen environment leads up to a reassessment of the classification of human macrophage polarizations.

Biomaterials 2019 Apr 13;208:98-109. Epub 2019 Apr 13.

Team Mechanobiology, Immunity and Cancer, Institute for Advanced Biosciences, Inserm U1209, CNRS UMR5309, La Tronche, France; Grenoble Alpes University, Grenoble, France; Research Department, University Hospital of Alpes, Grenoble, France. Electronic address:

Macrophages have multiple roles in development, tissue homeostasis and repair and present a high degree of phenotypic plasticity embodied in the concept of polarization. One goal of macrophage biology field is to characterize these polarizations at the molecular level. To achieve this task, it is necessary to integrate how physical environment signals are interpreted by macrophages under immune stimulation. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01429612193023
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http://dx.doi.org/10.1016/j.biomaterials.2019.04.018DOI Listing
April 2019
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Genetic susceptibility to West Nile virus infection in Camargue horses.

Res Vet Sci 2019 Apr 10;124:284-292. Epub 2019 Apr 10.

Department of Animal Genetics, Faculty of Veterinary Medicine, University of Veterinary and Pharmaceutical Sciences, Palackeho 1, Brno 61242, Czech Republic; CEITEC-VFU, University of Veterinary and Pharmaceutical Sciences, RG Animal Immunogenomics, Palackeho 1, Brno 61242, Czech Republic. Electronic address:

West Nile virus (WNV) is a mosquito-borne zoonotic neurotropic virus capable to cause lethal meningoencephalitis (WNE) in infected hosts such as birds, horses, and humans. Due to their sensitivity, horses serve as sentinel species in areas at risk. We studied a population of Camargue horses living in Southern France in two zones with endemic WNV circulation where WNV outbreaks were recorded in 2000 and 2003-4. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00345288183539
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http://dx.doi.org/10.1016/j.rvsc.2019.04.004DOI Listing
April 2019
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PD-1/PD-L1 Combinations in Advanced Urothelial Cancer: Rationale and Current Clinical Trials.

Clin Genitourin Cancer 2019 Mar 29. Epub 2019 Mar 29.

New York University Perlmutter Cancer Center, New York, NY.

Chemotherapy is no longer the only viable option for patients with locally advanced or metastatic urothelial carcinoma. Immunotherapy, as checkpoint inhibition, has received United States Food and Drug Administration approval in the preceding several years, both in the second-line and first-line for cisplatin-ineligible patients. Those who respond often do so durably; however, response rates in the first line are 23% to 24%, and are lower in the second line. Read More

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http://dx.doi.org/10.1016/j.clgc.2019.03.009DOI Listing

Safety Assessment of Immune-Mediated Adverse Reactions to Novel Food Proteins.

Trends Biotechnol 2019 Apr 17. Epub 2019 Apr 17.

Instituto de Investigación en Ciencias de la Alimentación, CIAL (CSIC-UAM), C/ Nicolás Cabrera, 9, Campus de la Universidad Autónoma de Madrid, 28049 Madrid, Spain.

Current international guidelines for the risk assessment of biotechnology-derived foods date back to 2003. We present new strategies and directions for assessing immune adverse reactions to novel food proteins. Understanding genetic factors involved in food allergy and the role of the gastrointestinal tract will streamline risk assessment strategies. Read More

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http://dx.doi.org/10.1016/j.tibtech.2019.03.010DOI Listing

Identification of multiple ferritin genes in Macrobrachium nipponense and their involvement in redox homeostasis and innate immunity.

Fish Shellfish Immunol 2019 Apr 17. Epub 2019 Apr 17.

The Key Laboratory of Zoological Systematics and Application, College of Life Sciences, Hebei University, Baoding, Hebei, 071002, China. Electronic address:

Based on the transcriptome database, we screened out four ferritin subunit genes (MnFer2-5) from the oriental river prawn Macrobrachium nipponense, which encode two non-secretory and two secretory peptides. MnFer2 and 4 possess a strictly conserved ferroxidase site, and MnFer3 has a non-typical ferroxidase site. MnFer5 seems to be a number of ferritin families, which has a distinct dinuclear metal binding motif, but lacks an iron ion channel, a ferroxidase site and a nucleation site. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10504648193028
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http://dx.doi.org/10.1016/j.fsi.2019.04.050DOI Listing
April 2019
2 Reads

Varieties of immunity activities and gut contents in tilapia with seasonal changes.

Fish Shellfish Immunol 2019 Apr 17. Epub 2019 Apr 17.

Freshwater Fisheries Research Center, Chinese Academy of Fishery Sciences, No. 9 Shanshui East Rd., Wuxi, Jiangsu, 214081, China. Electronic address:

We performed 16S rDNA sequencing of tilapia fecal samples to analyze changes in tilapia gut contents after cultivation of the fish in the presence of sandwich-like floating beds of Chinese medicinal herbs (5 and 10% planting-areas; 5% Polygonum cuspidatum). The interactive effects between water quality and blood and hepatic pro- and anti-inflammatory concentrations were also assessed. Our results showed that the water quality (i. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10504648193028
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http://dx.doi.org/10.1016/j.fsi.2019.04.042DOI Listing
April 2019
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Effect of Withania somnifer on CD38 expression on CD8+ T lymphocytes among patients of HIV infection.

Clin Immunol 2019 Apr 17. Epub 2019 Apr 17.

National HIV/AIDS Reference Laboratory, Department of Microbiology, All India Institute of Medical Sciences, New Delhi, India.

CD38 on CD8 + T cells is considered a reliable marker of HIV disease progression. Withania somnifer, a traditional ayurvedic medicine, has Th1 immunomodulatory properties. PBMCs from 38 HIV patients were exposed to Withania somnifer root extract at standardized concentration. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S15216616193009
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http://dx.doi.org/10.1016/j.clim.2019.04.003DOI Listing
April 2019
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Immunization of mice by the co-administration of codon-optimized HPV16 E7 and lL12 genes against HPV16-associated cervical cancer.

Microb Pathog 2019 Apr 17. Epub 2019 Apr 17.

Infectious Disease Research Center, Golestan University of Medical Sciences, Gorgan, Iran; Department of Microbiology, Faculty of Medicine, Golestan University of Medical Sciences, Gorgan, Iran. Electronic address:

Background: Various promising procedures have been used to improve the potency of DNA vaccines for the treatment of human papillomavirus type 16 (HPV16) infections. Interleukin-12 (IL12) is a powerful adjuvant that can contribute to T cell-mediated protection against many pathogens, specifically viruses. Considering the important role of T cell-mediated immunity in tumor clearance, the induction of these responses can help control the progression of tumors in animal models. Read More

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http://dx.doi.org/10.1016/j.micpath.2019.04.028DOI Listing

A TaqMan probe-based real-time PCR to differentiate porcine epidemic diarrhea virus virulent strains from attenuated vaccine strains.

Mol Cell Probes 2019 Apr 17. Epub 2019 Apr 17.

College of Animal Medicine, Hebei Agricultural University, Baoding, Hebei, 071000, China. Electronic address:

Porcine epidemic diarrhea virus (PEDV) is an important pathogen causing severe watery diarrhea, vomiting, dehydration, and death in sucking piglets. Attenuated vaccines have been used widely in sows in order to protect piglets through passive lactogenic immunity. Rapid and sensitive detection methods for differentiating attenuated vaccine strains from virulent ones are essential and practical in PEDV prevention and control. Read More

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http://dx.doi.org/10.1016/j.mcp.2019.04.003DOI Listing

Immunological consequences of chemotherapy: Single drugs, combination therapies and nanoparticle-based treatments.

J Control Release 2019 Apr 17. Epub 2019 Apr 17.

Department of Chemical Engineering, University of California, Santa Barbara, CA 93106, USA. Electronic address:

The tumor environment has been shown to employ several immunosuppressive mechanisms to evade cancer treatments. While immunotherapies actively reverse such mechanisms, and polarize the immune system against malignant cells, combination of immunotherapy with certain chemotherapeutics leads to increased efficacy compared to each treatment alone. At low doses, chemotherapy demonstrates several immunogenic effects that can favorably potentiate immunotherapies. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01683659193022
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http://dx.doi.org/10.1016/j.jconrel.2019.04.020DOI Listing
April 2019
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Screening of novel drugs for inhibiting hepatitis E virus replication.

J Virol Methods 2019 Apr 17. Epub 2019 Apr 17.

Division of Virology, Department of Infection and Immunity, Jichi Medical University School of Medicine, 3311-1 Yakushiji, Shimotsuke-Shi, Tochigi 329-0498, Japan. Electronic address:

Hepatitis E, which is caused by hepatitis E virus (HEV), is generally a self-limiting, acute, and rarely fatal disease. It is sometimes fulminant and lethal, especially during pregnancy. Indeed, it occasionally takes a chronic course in immunocompromised individuals. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01660934183029
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http://dx.doi.org/10.1016/j.jviromet.2019.04.017DOI Listing
April 2019
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Race-associated expression of MHC class I polypeptide-related sequence A (MICA) in prostate cancer.

Exp Mol Pathol 2019 Apr 17. Epub 2019 Apr 17.

Department of Pathology, University of Mississippi Medical Center, Jackson, MS, USA; Department of Radiation Oncology, University of Mississippi Medical Center, Jackson, MS, USA; Center for Clinical and Translational Science (CCTS), University of Mississippi School of Pharmacy & University of Mississippi Medical Center, Jackson, MS, USA. Electronic address:

Despite the lack of a complete understanding of the disparities involved, prostate cancer (PCa) has both higher incidence and death rates in African American Men (AAM) relative to those of Caucasian American Men (CAM). MHC class I polypeptide related sequence A (MICA) is an innate immunity protein involved in tumor immunoevasion. Due to a lack of reports of race-specific expression of MICA in PCa, we evaluated MICA expression in patients' tumors and in cell lines from a racially diverse origin. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00144800193014
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http://dx.doi.org/10.1016/j.yexmp.2019.04.010DOI Listing
April 2019
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Intranasal immunization with recombinant Trichinella spiralis serine protease elicits protective immunity in BALB/c mice.

Exp Parasitol 2019 Apr 17. Epub 2019 Apr 17.

Department of Parasitology, Medical College, Zhengzhou University, 40 Daxue Road, Zhengzhou, 450052, PR China. Electronic address:

The aim of this study was to observe the intestinal mucosal/systemic responses triggered by intranasal vaccination using recombinant Trichinella spiralis serine protease (rTsSP) and its capacity to elicit immune protection against larva challenge in a murine model. rTsSP coupled with cholera toxin B subunit (CTB) was used to vaccinate mice via intranasal route. The results revealed that intranasal vaccination with rTsSP plus CTB elicited significantly intestinal local sIgA response and a TsSP-specific systemic antibody response in vaccinated mice. Read More

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http://dx.doi.org/10.1016/j.exppara.2019.04.006DOI Listing

Impact of CMV upon immune aging: facts and fiction.

Med Microbiol Immunol 2019 Apr 19. Epub 2019 Apr 19.

Department of Immunobiology and the University of Arizona Center on Aging, University of Arizona College of Medicine-Tucson, Tucson, AZ, 85718, USA.

Aging is accompanied by significant defects in immunity and compromised responses to new, previously unencountered microbial pathogens. Most humans carry several persistent or latent viruses as they age, interacting with the host immune systems for years. In that context maybe the most studied persistent virus is Cytomegalovirus, infamous for its ability to recruit very large T cell responses which increase with age and to simultaneously evade elimination by the immune system. Read More

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http://link.springer.com/10.1007/s00430-019-00605-w
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http://dx.doi.org/10.1007/s00430-019-00605-wDOI Listing
April 2019
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Persistent circulation of vaccine serotypes and serotype replacement after five years of UK infant immunisation with PCV13.

J Infect Dis 2019 Apr 20. Epub 2019 Apr 20.

Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, OX LE, United Kingdom.

Background: Following programmatic introduction of the 13-valent pneumococcal conjugate vaccine (PCV13), there is residual carriage and disease due to PCV13 covered serotypes.

Methods: 988 PCV13-immunised children aged 13-48 months were enrolled between February 2014 and August 2015 (late-PCV13), and had nasopharyngeal pneumococcal carriage compared with 567 PCV7-immunised children enrolled into a study between November 2010 and September 2011 (early-PCV13). Nasopharyngeal pneumococci were molecular-serotyped by microarray. Read More

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https://academic.oup.com/jid/advance-article/doi/10.1093/inf
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http://dx.doi.org/10.1093/infdis/jiz178DOI Listing
April 2019
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Interaction of RNA viruses of the natural virome with the African malaria vector, Anopheles coluzzii.

Sci Rep 2019 Apr 19;9(1):6319. Epub 2019 Apr 19.

Department of Parasites and Insect Vectors, Unit of Genetics and Genomics of Insect Vectors, Institut Pasteur, Paris, 75724 CEDEX 15, France.

Mosquitoes are colonized by a little-studied natural virome. Like the bacterial microbiome, the virome also probably influences the biology and immunity of mosquito vector populations, but tractable experimental models are lacking. We recently discovered two novel viruses in the virome of wild Anopheles and in colonies of the malaria vector Anopheles coluzzii: Anopheles C virus and Anopheles cypovirus. Read More

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http://dx.doi.org/10.1038/s41598-019-42825-3DOI Listing

Pregnane X receptor activation triggers rapid ATP release in primed macrophages that mediates NLRP3 inflammasome activation.

J Pharmacol Exp Ther 2019 Apr 19. Epub 2019 Apr 19.

University of Calgary;

The pregnane X receptor (PXR) is a ligand-activated nuclear receptor that acts as a xenobiotic sensor, responding to compounds of foreign origin, including pharmaceutical compounds, environmental contaminants and natural products, to induce transcriptional events that regulate drug detoxification and efflux pathways. As such, the PXR is thought to play a key role in the protecting the host from xenobiotic exposure. More recently, the PXR has been reported to regulate the expression of innate immune receptors in the intestine and modulate inflammasome activation in the vasculature. Read More

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http://jpet.aspetjournals.org/lookup/doi/10.1124/jpet.118.25
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http://dx.doi.org/10.1124/jpet.118.255679DOI Listing
April 2019
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Postvaccination Febrile Seizure Severity and Outcome.

Pediatrics 2019 Apr 19. Epub 2019 Apr 19.

National Centre for Immunisation Research and Surveillance, Children's Hospital at Westmead, Sydney, Australia.

Background: Febrile seizures (FSs) are a common pediatric condition caused by a sudden rise in temperature, affecting 3% to 5% of children aged ≤6 years. Although vaccination can cause FSs, little is known on whether FSs occurring in the time soon after vaccination (vaccine-proximate febrile seizures [VP-FSs] differ clinically from non-vaccine-proximate febrile seizures [NVP-FSs]). We compared the clinical profile and outcomes of VP-FS to NVP-FS. Read More

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http://dx.doi.org/10.1542/peds.2018-2120DOI Listing
April 2019
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Rapid generation of multivirus-specific T lymphocytes for the prevention and treatment of respiratory viral infections.

Haematologica 2019 Apr 19. Epub 2019 Apr 19.

Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, TX, USA

Respiratory tract infections due to community-acquired respiratory viruses including respiratory syncytial virus, Influenza, parainfluenza virus 3 and human metapneumovirus are detected in up to 40% of allogeneic hematopoietic stem cell transplant recipients in whom they cause severe symptoms including pneumonia and bronchiolitis and can be fatal. Given the lack of effective antivirals and the data from our group demonstrating that adoptively transferred ex vivo-expanded virus-specific T cells can be clinically beneficial for the treatment of both latent (Epstein-Barr virus, cytomegalovirus, BK virus, human herpesvirus 6) and lytic (adenovirus) viruses, we investigated the potential for extending this immunotherapeutic approach to respiratory viruses. We now describe a system that rapidly generates a single preparation of polyclonal (CD4+ and CD8+) virus-specific T cells reactive against 12 antigens derived from 4 viruses (respiratory syncytial virus, Influenza, parainfluenza virus 3 and human metapneumovirus) that commonly cause post-transplant morbidity and mortality. Read More

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http://dx.doi.org/10.3324/haematol.2018.206896DOI Listing