10,620 results match your criteria Immune Thrombocytopenic Purpura


Blood Cell Disorders and the Nervous System.

Continuum (Minneap Minn) 2020 Jun;26(3):659-674

Purpose Of Review: This article discusses the epidemiology, diagnosis, treatment, and prevention of neurologic complications of common and rare blood cell disorders.

Recent Findings: A growing number of preventive treatment options are available for stroke in sickle cell disease. Paroxysmal nocturnal hemoglobinuria and immune thrombocytopenia can lead to stroke. Read More

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http://dx.doi.org/10.1212/CON.0000000000000858DOI Listing

Immune thrombocytopenic purpura caused by the over-the-counter weight supplement Root of Tejocote ( species).

Clin Case Rep 2020 May 20;8(5):872-876. Epub 2020 Mar 20.

Department of Hematology and Oncology University of Rochester Rochester New York.

Over-the-counter supplements, such as Alipotec which often purported to amplify weight loss and readily available in naturopathic shops, can have clinically significant patient outcomes including severe cytopenia, and even inducing immune thrombocytopenic purpura. Read More

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http://dx.doi.org/10.1002/ccr3.2804DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7250972PMC

In reply to the letter to the editor "Tele(oral)medicine: A new approach during the COVID-19 crisis".

Oral Dis 2020 May 31. Epub 2020 May 31.

AssistantProfessor, Oral Medicine Department, Facultad de Odontologia, Universidad Nacional de Córdoba, Córdoba, Argentina.

We would like tocongratulate Villa et al fora recent published letter to the editor(Villa et al; 2020), emphasizing the use of tele(oral)medicine as an effective diagnostic tool(Estai et al, 2018),which could be usefulin the current time of crisis.The COVID-19 pandemic, and the social isolation measures mandatedby health authorities haveled toa reassessing of the professional practicesin our Dental College. Read More

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http://dx.doi.org/10.1111/odi.13454DOI Listing

Idiopathic thrombocytopenic purpura treatment in a relapsed/refractory multiple myeloma patient after chimeric antigen receptor T cell therapy.

Regen Ther 2020 Jun 15;14:271-274. Epub 2020 May 15.

Bone Marrow Transplantation Center, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, 310000, China.

The adoptive transfer of CAR-T cells, which are modified T cells expressing chimeric antigen receptors (CARs), to target B cell maturation antigen (BCMA) has demonstrated impressive results in treating relapsed/refractory multiple myeloma. Although BCMA CAR-T therapy induces certain complications in some patients, idiopathic thrombocytopenic purpura (ITP) has not been reported as one of them. To the best of our knowledge, this is the first report of the successful treatment of ITP that arose in a relapsed/refractory multiple myeloma patient following anti-BCMA CAR-T cell infusion. Read More

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http://dx.doi.org/10.1016/j.reth.2020.03.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7232090PMC

Development and validation of a prediction model (AHC) for early identification of refractory thrombotic thrombocytopenic purpura using nationally representative data.

Br J Haematol 2020 May 26. Epub 2020 May 26.

Peking University People's Hospital, Peking University Institute of Hematology, Beijing, China.

Immune-mediated thrombotic thrombocytopenic purpura (iTTP) is a rare and life-threatening haematological emergency. Although therapeutic plasma exchange together with corticosteroids achieve successful outcomes, a considerable number of patients remain refractory to this treatment and require early initiation of intensive therapy. However, a method for the early identification of refractory iTTP is not available. Read More

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http://dx.doi.org/10.1111/bjh.16767DOI Listing

Heterogeneity of diagnosis, treatment, and management for immune thrombotic thrombocytopenic purpura: Are we still peering through the looking glass?

J Clin Apher 2020 May 25. Epub 2020 May 25.

Department of Pathology and Laboratory Medicine, University of North Carolina, Chapel Hill, North Carolina, USA.

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http://dx.doi.org/10.1002/jca.21777DOI Listing

[Aortic aneurysm in a patient with Wiskott-Aldrich syndrome].

Rev Alerg Mex 2020 Jan-Mar;67(1):87-93

Hospital Pediátrico de Sinaloa, Departamento de Inmunología y Alergia, Sinaloa, México.

Background: The Wiskott-Aldrich syndrome is a combined immunodeficiency associated with a syndrome linked to the X chromosome, which is characterized by eczema, recurrent infections, and thrombocytopenia. Other manifestations include autoimmune disorders such as hemolytic anemia or thrombocytopenic purpura mediated by the immune system, increased susceptibility to malignant tumors, including lymphoma or leukemia.

Clinical Case: A 7-year-old male patient with a diagnosis of Wiskott-Aldrich syndrome who was treated with intravenous gamma globulin, antimicrobial prophylaxis with trimethoprim/sulfamethoxazole, and fluconazole, as well as with prednisone and cyclosporine due to hemolytic anemia and uveitis. Read More

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http://dx.doi.org/10.29262/ram.v67i1.696DOI Listing

Rotational thromboelastometry parameters as predicting factors for bleeding in immune thrombocytopenic purpura.

Hematol Oncol Stem Cell Ther 2020 May 15. Epub 2020 May 15.

Department of Hematology, Cho Ray Hospital, Ho Chi Minh City, Viet Nam.

Objective/background: Patients with immune thrombocytopenic purpura (ITP) often present with a severe reduction in platelet counts and suffer from an increased risk of bleeding. However, platelet counts do not accurately predict bleeding risk in these patients.

Methods: We thereby conducted a case series prospective study to compare the ability to predict hemorrhage in ITP patients between platelet counts and various rotational thromboelastometry (ROTEM) parameters. Read More

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http://dx.doi.org/10.1016/j.hemonc.2020.05.003DOI Listing

A Rare Case of Immune Thrombocytopenic Purpura Secondary to COVID-19.

J Med Virol 2020 May 22. Epub 2020 May 22.

COVID-19 Research Center, Institute of Laboratory Medicine, Jinling Hospital, Nanjing University School of Medicine, Nanjing, Jiangsu, 210002, China.

Coronavirus Disease 2019 (COVID-19) is a newly emerging infectious disease caused by a novel coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). After its first occurrence in Wuhan of China from December 2019, COVID-19 rapidly spread around the world. Studies have shown that coagulation dysfunction is one of the important reason causing death of COVID-19 patients and appeared in many patients. Read More

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http://dx.doi.org/10.1002/jmv.26051DOI Listing
May 2020
2.347 Impact Factor

Romiplostim for management of refractory immune thrombocytopenic purpura in the immediate postpartum period.

BMJ Case Rep 2020 May 18;13(5). Epub 2020 May 18.

Department of OB/GYN, Trinity Health of New England, Hartford, Connecticut, USA

We present a case of a pregnant woman with chronic immune thrombocytopenic purpura and chronic hypertension who developed pre-eclampsia with severe features warranting delivery. Her overall clinical picture and liver enzymes improved in the immediate postpartum period, however, aggressively progressing thrombocytopenia posed a diagnostic dilemma to the interdisciplinary care team. After failing to respond to first-line therapies including high-dose corticosteroids and intravenous immunoglobulin, she was successfully managed with a trial of the thrombopoietin receptor agonist, Romiplostim. Read More

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http://dx.doi.org/10.1136/bcr-2020-234335DOI Listing

Steroid-Induced Diabetes Ketoacidosis in an Immune Thrombocytopenia Patient: A Case Report and Literature Review.

Am J Case Rep 2020 May 18;21:e923372. Epub 2020 May 18.

Department of Internal Medicine, King Abdulaziz Specialist Hospital, Taif, Saudi Arabia.

BACKGROUND Steroids are used as anti-inflammatory agents, administered for a variety of medical conditions, either as short- or long-term treatment. Steroid use is associated with many adverse effects, including hyperglycemia, but ketoacidosis is rare. CASE REPORT We present the case of a 53-year-old woman who developed diabetic ketoacidosis after administration of methylprednisolone during treatment of immune thrombocytopenic purpura. Read More

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http://dx.doi.org/10.12659/AJCR.923372DOI Listing

[Right Atrial Thrombus which was Difficult to Differentiate from Tumor;Report of a Case].

Kyobu Geka 2020 Mar;73(3):227-229

Department of Cardiovascular Surgery, Nihonkai General Hospital, Sakata, Japan.

We report a case of a 79-year-old woman with a right atrial mass. She had a history of hypertension, idiopathic thrombocytopenic purpura, and chronic atrial fibrillation. Computed tomography and transthoracic echocardiography showed a 31×31 mm mass in the right atrium. Read More

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Successful Treatment with Edoxaban for Disseminated Intravascular Coagulation in a Case of Aortic Dissection Complicated with Immune Thrombocytopenic Purpura.

Intern Med 2020 May 8. Epub 2020 May 8.

Department of Hematology, Niigata Prefectural Shibata Hospital, Japan.

A 70-year-old woman was hospitalized for exacerbation of chronic idiopathic thrombocytopenic purpura (ITP) and disseminated intravascular coagulation (DIC) from old aortic dissection. Initially, we increased the dose of prednisolone for ITP. However, her bleeding tendency caused by DIC worsened despite the rapid recovery of her platelet count, and the required amount of fresh-frozen plasma for transfusion increased. Read More

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http://dx.doi.org/10.2169/internalmedicine.4255-19DOI Listing

Pregnancy and non-pregnancy related immune thrombotic thrombocytopenic purpura in women of reproductive age.

J Thromb Thrombolysis 2020 May 9. Epub 2020 May 9.

Hematology Department, Hadassah-Hebrew University Medical Center, POB 12000, Jerusalem, Israel.

Pregnancy is a precipitating factor for immune thrombotic thrombocytopenic purpura (iTTP). We compared the clinical course and outcomes of iTTP in women of reproductive age, between those with pregnancy- and non-pregnancy-related iTTP. A review of all reproductive-aged women diagnosed with iTTP during 2010-2019 in seven university hospitals in Israel. Read More

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http://dx.doi.org/10.1007/s11239-020-02133-4DOI Listing

Research progress in relation of infection with pregnancy-related diseases and adverse pregnancy outcomes.

Authors:
Bai Zhou Fen Wang

Zhong Nan Da Xue Xue Bao Yi Xue Ban 2020 Mar;45(3):338-344

Depatment of Gastroenterology, Third Xiangya Hospital, Central South University, Changsha 410013

() is a Gram-negative microaerobic bacterium, which is parasitic on gastric mucosa and is associated with the pathogenesis of chronic gastritis, gastric ulcer, gastric cancer and other gastric diseases. Meanwhile, the infection is related with pregnancy-related diseases, pregnancy outcomes, and the health status of offspring, such as infertility, premature delivery, abortion, infection of newborn and neural tube defects. infection is also related to hyperemesis of pregnancy, preeclampsia, gestational diabetes mellitus, iron deficiency anemia, idiopathic thrombocytopenic purpura. Read More

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http://dx.doi.org/10.11817/j.issn.1672-7347.2020.190032DOI Listing

Response to 'Risk of systemic lupus erythematosus in patients with idiopathic thrombocytopenic purpura' by Xie and Zhang.

Ann Rheum Dis 2020 May 7. Epub 2020 May 7.

Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan

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http://dx.doi.org/10.1136/annrheumdis-2020-217694DOI Listing

Caplacizumab for treatment of thrombotic thrombocytopenic purpura in a patient with anaphylaxis to fresh-frozen plasma.

Transfusion 2020 May 1. Epub 2020 May 1.

Diagnostic Laboratories, Versiti Blood Center of Wisconsin, Milwaukee, Wisconsin, USA.

Background: Plasma exchange with plasma replacement has been the mainstay for the treatment of thrombotic thrombocytopenic purpura (TTP) for several decades. Recently an anti-von Willebrand factor (VWF) medication, caplacizumab, has been approved for treatment of TTP when used with plasma exchange. We report a patient with immune-mediated TTP that had an anaphylactic reaction to plasma who was then given caplacizumab daily for 1 week without further plasma exchange therapy with a good clinical and laboratory response. Read More

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http://dx.doi.org/10.1111/trf.15823DOI Listing

Open ADAMTS13, induced by antibodies, is a biomarker for subclinical immune-mediated thrombotic thrombocytopenic purpura.

Blood 2020 04 30. Epub 2020 Apr 30.

KU Leuven Campus Kulak Kortrijk, Kortrijk, Belgium.

Recently, we showed that during the acute phase of immune-mediated thrombotic thrombocytopenic purpura (iTTP), ADAMTS13 circulates in an open conformation. Although the cause of this conformational change in acute iTTP remains elusive, ADAMTS13 is mainly closed in iTTP patients (i) in remission with an ADAMTS13 activity >50% and undetectable anti-ADAMTS13 autoantibodies, and (ii) after rituximab treatment, suggesting a role for anti-ADAMTS13 autoantibodies. Therefore, IgGs from 18 acute iTTP patients were purified and added to closed ADAMTS13 in healthy donor plasma. Read More

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http://dx.doi.org/10.1182/blood.2019004221DOI Listing

Bone Marrow Langerhans Cell Histiocytosis in Association with Kasabach-Merritt Syndrome: The Difficulty of a Differential Diagnosis.

Case Rep Oncol 2020 Jan-Apr;13(1):408-413. Epub 2020 Apr 14.

Department of Internal Medicine II, Professor Doutor Fernando Fonseca Hospital, Amadora, Portugal.

Langerhans cell histiocytosis is a rare haematological disorder with variable clinical findings and a high mortality rate. On the other hand, Kasabach-Merritt syndrome is of rare onset at adult age, requiring the simultaneous presentation of vascular lesion, thrombocytopenia, and consumptive coagulopathy. We present the first reported case of both diseases in a single patient and highlight the difficulties of diagnostic. Read More

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http://dx.doi.org/10.1159/000506539DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7184841PMC

Low levels of ADAMTS-13 with high anti-ADAMTS-13 antibodies during remission of immune-mediated thrombotic thrombocytopenic purpura highly predict for disease relapse: A multi-institutional study.

Am J Hematol 2020 Apr 29. Epub 2020 Apr 29.

Immunohematology and Transfusion Medicine, Hospital Papa Giovanni XXIII, Bergamo, Italy.

Immune-mediated thrombotic thrombocytopenic purpura (iTTP) is a life-threatening immune-mediated thrombotic microangiopathy. Daily therapeutic plasma exchange (TPE) and the optimized use of rituximab have strikingly improved the outcome of this disease, however the rate of disease recurrence remains high. Specific predictors of relapse in patients in remission can be relevant for an optimal patient management. Read More

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http://dx.doi.org/10.1002/ajh.25845DOI Listing

Risk of systemic lupus erythematosus in patients with idiopathic thrombocytopenic purpura: a need for a more accurate control group?

Ann Rheum Dis 2020 Apr 27. Epub 2020 Apr 27.

Centre National de Référence des Maladies Systémiques et Autoimmunes Rares Est Sud-Ouest (RESO), Department of Rheumatology, Strasbourg, France.

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http://dx.doi.org/10.1136/annrheumdis-2020-217651DOI Listing

Intravenous Immunoglobulin-Associated Hemolytic Anemia.

Lab Med 2020 Apr 27. Epub 2020 Apr 27.

Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee.

Intravenous immunoglobulin (IVIG) is an important therapeutic tool for the treatment of a variety of conditions, including immune thrombocytopenic purpura (ITP). Although IVIG has many approved indications and is typically well tolerated, a number of adverse effects have been reported. Hemolysis is a documented but under-recognized adverse effect associated with large individual or cumulative doses of IVIG. Read More

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http://dx.doi.org/10.1093/labmed/lmaa019DOI Listing

miR-106b-5p induces immune imbalance of Treg/Th17 in immune thrombocytopenic purpura through NR4A3/Foxp3 pathway.

Cell Cycle 2020 Jun 23;19(11):1265-1274. Epub 2020 Apr 23.

Department of Hematology, Children's Hospital of Soochow University , Soochow, Jiangsu, China.

Background: Immune imbalance of regulatory T cells (Treg)/T helper 17 cells (Th17) contributes to the development of immune thrombocytopenic purpura (ITP). The dysregulation of miRNAs is important in the development of ITP. However, the role of miR-106b-5p in Treg/Th17 imbalance remains unknown in ITP. Read More

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http://dx.doi.org/10.1080/15384101.2020.1746485DOI Listing

[Research Progress on New Drug Therapy for Primary Immune Thrombocytopenic Purpura in Adults--Review].

Zhongguo Shi Yan Xue Ye Xue Za Zhi 2020 Apr;28(2):677-681

Department of Hematology, The First Affiliated Hospital of Gannan Medical College, Ganzhou 341000, Jiangxi Province,

Immune thrombocytopenia (ITP) is an immune disease characterized by an increased risk of hemorrhagic disease caused by a decrease in platelet count. At present, the first line, second-line treatment can not completely or maintain continuous remission of ITP. New treatments in recent research include stimulating platelet-producing drugs, Syk inhibitors, and molecular-targeted drugs, etc. Read More

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http://dx.doi.org/10.19746/j.cnki.issn.1009-2137.2020.02.053DOI Listing

[Pathogenesis of Immune Thrombocytopenic Purpura (ITP) by MiRNA-30a-Mediated Th17 Cell Differentiation].

Zhongguo Shi Yan Xue Ye Xue Za Zhi 2020 Apr;28(2):588-594

Department of Hematology, Children's Hospital Affiliated to Soochow University, Suzhou 215000, Jiangsu Province, China.

Objective: To investigate whether miRNA-30a is involved in the pathogenesis of ITP by affecting the differentiation of Th17 cells, and to explore its possible mechanism of miRNA-30a involved in the pathogenesis of ITP through the verification of the target gene SOCS3 for the prediction of miRNA-30a.

Methods: Firstly, a chronic ITP mouse model was established. The expression of miRNA-30a and RORγt in the spleen mononuclear cells were detected and their correlation were analyzed. Read More

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http://dx.doi.org/10.19746/j.cnki.issn.1009-2137.2020.02.039DOI Listing

Thrombotic thrombocytopenic purpura with Graves' disease during pregnancy.

Proc (Bayl Univ Med Cent) 2020 Apr 23;33(2):270-272. Epub 2020 Jan 23.

Department of Pathology, Baylor University Medical CenterDallasTexas.

Thrombotic thrombocytopenic purpura may be seen with several autoimmune disorders such as immune thrombocytopenia purpura, immune hemolytic anemia, and systemic lupus erythematosus, but it is rarely associated with Graves' disease. We report a patient with thrombotic thrombocytopenic purpura associated with Graves' disease. Read More

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http://dx.doi.org/10.1080/08998280.2020.1713029DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7155955PMC

Population-based studies in systemic lupus erythematosus: immune thrombocytopenic purpura or 'blood-dominant' lupus?

Ann Rheum Dis 2020 Jun 20;79(6):683-684. Epub 2020 Apr 20.

Rheumatology and Clinical Immunology Unit, 4th Department of Internal Medicine, University Hospital "Attikon", Athens, Greece

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http://dx.doi.org/10.1136/annrheumdis-2020-217356DOI Listing

Slc35a1 deficiency causes thrombocytopenia due to impaired megakaryocytopoiesis and excessive platelet clearance in the liver.

Haematologica 2020 Apr 17. Epub 2020 Apr 17.

Oklahoma Medical Research Foundation

Sialic acid is a common terminal residue of glycans on proteins and acidic sphingolipids such as gangliosides with important biological functions. The sialylation process is controlled by more than 20 different sialyltransferases, many of which exhibit overlapping functions. Thus, it is difficult to determine the overall biological function of sialylation by targeted deletion of individual sialyltransferase. Read More

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http://dx.doi.org/10.3324/haematol.2019.225987DOI Listing

Serendipitous Finding of Asymptomatic Babesiosis in a Patient With Symptomatic Thrombocytopenia.

J Hematol 2019 Dec 25;8(4):168-170. Epub 2019 Dec 25.

Division of Hematology/Oncology, Lenox Hill Hospital, New York, NY, USA.

We report a case of isolated immune thrombocytopenic purpura (ITP) as a result of babesiosis infection. The patient initially presented with a history, physical exam and laboratory findings consistent with idiopathic thrombocytopenic purpura. She was treated with standard of care therapy without clinical response. Read More

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http://dx.doi.org/10.14740/jh570DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7155809PMC
December 2019

Aggressive Disease and Rare Sequelae in a Unique Case of Atypical Hemolytic Uremic Syndrome Secondary to Adult Onset Still's Disease.

J Hematol 2019 Jun 30;8(2):64-67. Epub 2019 Jun 30.

Division of Hematology and Cellular Therapy, Western Pennsylvania Hospital, Pittsburgh, PA, USA.

Atypical hemolytic uremic syndrome (aHUS) is a rare form of thrombotic microangiopathy (TMA) which generally presents as a triad of thrombocytopenia, hemolytic anemia and renal failure. We present the case of a 69-year-old woman with ongoing fevers, arthralgias, diffuse rash and pharyngitis for 3 months. Investigation revealed an elevated erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), and ferritin; however, autoimmune and infectious studies were unremarkable, raising the suspicion for adult onset Still's disease (AOSD). Read More

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http://dx.doi.org/10.14740/jh491DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7153680PMC

Immune Thrombocytopenic Purpura in a Patient with Covid-19.

N Engl J Med 2020 04 15;382(18):e43. Epub 2020 Apr 15.

Hôpitaux Universitaires de Strasbourg, Strasbourg, France.

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http://dx.doi.org/10.1056/NEJMc2010472DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7179995PMC

Vitamin D Insufficiency is Not Associated With Pediatric and Adolescent Immune Thrombocytopenia: A Study in Conjunction With its Receptor Genetic Polymorphisms.

J Pediatr Hematol Oncol 2020 Apr 13. Epub 2020 Apr 13.

Departments of Clinical Pathology.

Idiopathic thrombocytopenic purpura (ITP) is a heterogeneous immunologic disorder. Vitamin D has immune-modulatory effects. The pleiotropic effects of vitamin D are exerted via vitamin D receptor (VDR) and its genetic alterations could influence its functions. Read More

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http://dx.doi.org/10.1097/MPH.0000000000001801DOI Listing

Immune Thrombocytopenia Secondary to Hodgkin's Lymphoma in Children

Isr Med Assoc J 2020 04;22(4):224-226

Department of Pediatrics B, Emek Medical Center, Afula, Israel.

Background: Immune thrombocytopenia (ITP) is an autoimmune disorder of variable origin that results in bleeding and decreased platelet count. Autoimmune abnormalities have been described in patients with malignancies including non-Hodgkin's lymphoma but are rarely described in patients with Hodgkin's lymphoma.

Objectives: To describe an unusual presentation of Hodgkin's lymphoma in an unusual age and alarm pediatricians of the challenging diagnosis. Read More

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Use of romiplostim in pregnancy for refractory idiopathic thrombocytopenic purpura: Two case reports with maternal and fetal outcomes and literature review.

Obstet Med 2020 Mar 29;13(1):45-50. Epub 2018 May 29.

Lyell McEwin Hospital, Elizabeth Vale, Australia.

Idiopathic thrombocytopenic purpura is a relatively rare complication occurring in pregnancy, with the potential for serious maternal and fetal outcomes. Rarely, the poor response to established first-line therapies results in consideration of second-line therapies, which may have poorly understood risks to the fetus. We report two women with severe idiopathic thrombocytopenic purpura during pregnancy unresponsive to corticosteroids and intravenous immunoglobulin who were treated with romiplostim, a thrombopoietin receptor agonist. Read More

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http://dx.doi.org/10.1177/1753495X18773960DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7133099PMC

Clinical, immunological and genetic characteristic of patients with clinical phenotype associated to LRBA-deficiency in Colombia.

Colomb Med (Cali) 2019 Sep 30;50(3):176-191. Epub 2019 Sep 30.

Universidad de Antioquia UdeA, Facultad de Medicina, Grupo de Inmunodeficiencias Primarias, Medellin, Colombia.

Background: LPS-responsive beige -like anchor protein (LRBA) deficiency is a primary immunodeficiency disease caused by loss of LRBA protein expression, due to biallelic mutations in gene. LRBA deficiency patients exhibit a clinically heterogeneous syndrome. The main clinical complication of LRBA deficiency is immune dysregulation. Read More

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http://dx.doi.org/10.25100/cm.v50i3.3969DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7141146PMC
September 2019

Femoral pseudotumor secondary to injury in a patient with idiopathic thrombocytopenic purpura: Case report.

Medicine (Baltimore) 2020 Apr;99(15):e19788

Department of Radiology, The Third Hospital of Hebei Medical University, Shijiazhuang Hebei Province, China.

Rationale: Idiopathic thrombocytopenic purpura (ITP) is the condition of having a low platelet count of unknown causes and is a poorly understood acquired hemorrhagic disease involving destruction of platelets in the reticuloendothelial system induced by antiplatelet antibodies. Patients with ITP can have traumatic intra-articular, intraosseous or soft tissue hemorrhage which may present as a rare intraosseous pseudotumor on medical imaging.

Patient Concerns: A 30-year old male patient had complaint of pain in the right leg for 1 year. Read More

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http://dx.doi.org/10.1097/MD.0000000000019788DOI Listing
April 2020
5.723 Impact Factor

The state of vaccine safety science: systematic reviews of the evidence.

Lancet Infect Dis 2020 May 9;20(5):e80-e89. Epub 2020 Apr 9.

Department of International Health, Johns Hopkins University, Baltimore, MD, USA; Institute of Vaccine Safety, Johns Hopkins University, Baltimore, MD, USA; Department of Health, Behavior & Society, Johns Hopkins University, Baltimore, MD, USA. Electronic address:

This Review updates the scientific evidence assessing possible causal associations of adverse events following immunisation (AEFI) compiled in the 2012 report from the Institute of Medicine and the 2014 report from the Agency for Healthcare Research and Quality. For 12 of 46 AEFI examined, a causal relationship has been established with at least one vaccine currently routinely recommended to the general USA population: anaphylaxis, arthralgia or arthritis (mild, acute, and transient, not chronic), deltoid bursitis (when vaccine is administered improperly), disseminated varicella infection (in immune deficient individuals for whom the varicella vaccine is contraindicated), encephalitis, febrile seizures, Guillain-Barré syndrome, hepatitis (in immune deficient individuals for whom the varicella vaccine is contraindicated), herpes zoster, immune thrombocytopenic purpura, meningitis, and syncope. Other than mild acute and transient arthralgia or arthritis, which is very common in adult women after rubella vaccine, these adverse reactions are rare or very rare. Read More

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http://dx.doi.org/10.1016/S1473-3099(20)30130-4DOI Listing

Immune Thrombocytopenic Purpura (ITP) as an Uncommon Extraintestinal Complication of Crohn's Disease: Case Vignette and Systematic Literature Review.

Case Rep Hematol 2020 26;2020:4785759. Epub 2020 Mar 26.

Harbor-UCLA Medical Center, Department of Medicine, Division of Hematology & Medical Oncology, Torrance, CA, USA.

While the association of immune thrombocytopenic purpura (ITP) and inflammatory bowel disease (IBD) has been described in a few case reports, management of ITP as an extraintestinal manifestation of Crohn's disease (CD) is less studied. There are approximately a dozen cases describing the management of patients dually diagnosed with CD/ITP. Previous reports postulated that the mechanism of ITP in CD was through the presence of circulating immune complexes in the serum and antigenic mimicry due to increased mucosal permeability in active colitis, versus increased mucosal production of TH1-type proinflammatory cytokines during CD flares, which may account for remission of ITP with surgery for CD. Read More

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http://dx.doi.org/10.1155/2020/4785759DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7136770PMC

Massive hemoperitoneum from hemorrhagic corpus luteum in a patient with acquired amegakaryocytic thrombocytopenic purpura.

Clin Case Rep 2020 Apr 7;8(4):719-721. Epub 2020 Mar 7.

Department of Obstetrics and Gynaecology Federal Medical Centre Yenagoa Nigeria.

Doctors should think of a spectrum of differential diagnoses in patients presenting with acute abdominal pain ranging from medical, surgical, and gynecological conditions. Proper laboratory and radiological tests including bone marrow study are advised. Read More

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http://dx.doi.org/10.1002/ccr3.2767DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7141734PMC

Re: JSLS. 2018;22(4):1-9. Prediction of Success Following Laparoscopic Splenectomy for Immune Thrombocytopenic Purpura Seems Still so far from to be Understood.

Authors:
Vecchio Rosario

JSLS 2020 Apr-Jun;24(2)

Department of General Surgery and Medico-Surgical Specialties, University of Catania, Italy, Policlinico Vittorio Emanuele Hospital, Via S. Sofia 78, 95123 Catania, Italy.

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http://dx.doi.org/10.4293/JSLS.2020.00010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7141486PMC

Thrombocytopenia in Pregnancy: Approach to Diagnosis and Management.

Semin Thromb Hemost 2020 Apr 7;46(3):256-263. Epub 2020 Apr 7.

Division of Hematology/Oncology, Department of Medicine, Mass General Cancer Center, Massachusetts General Hospital, Boston, Massachusetts.

The impact of thrombocytopenia varies widely depending on the underlying pathophysiology driving it. The biggest challenge in managing thrombocytopenia in pregnancy is accurately identifying the responsible pathophysiology-a task made difficult given the tremendous overlap in clinical and laboratory abnormalities associated with different thrombocytopenia processes. The most common etiologies of thrombocytopenia in pregnancy range from physiology deemed benign to those that are life-threatening to the mother and fetus. Read More

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http://dx.doi.org/10.1055/s-0040-1708842DOI Listing

Immune-Mediated Thrombotic Thrombocytopenic Purpura: A Narrative Review of Diagnosis and Treatment in Adults.

Semin Thromb Hemost 2020 Apr 7;46(3):289-301. Epub 2020 Apr 7.

Sydney Medical School, University of Sydney, Sydney, Australia.

Immune-mediated thrombotic thrombocytopenic purpura (iTTP) is a rare and potentially lethal disease characterized by fragmentary hemolysis, moderate-to-severe thrombocytopenia, end-organ dysfunction, and severely reduced ADAMTS13 levels (< 10%). Survival in iTTP has improved significantly since the introduction of plasma exchange as standard therapy combined with immune suppression to address the underlying pathophysiology. A host of challenges remain including prompt recognition of the disease, treatment of the end-organ effects of the disease, improving the early mortality rate, significantly reducing the relapse rate as well as addressing refractory disease. Read More

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http://dx.doi.org/10.1055/s-0040-1708541DOI Listing

Multiple myeloma with concurrent immune thrombocytopenic purpura.

Ecancermedicalscience 2020 20;14:1012. Epub 2020 Feb 20.

Houston Methodist Cancer Center/Weill Cornell Medicine, Houston, TX 77030, USA.

Multiple myeloma (MM) is the second most common haematological malignancy in the USA. MM has been linked to various autoimmune disorders in many studies; one systemic review even suggested an increased risk of MM among patients with autoimmune disorders. MM is associated with many haematological, rheumatologic and neurological conditions. Read More

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http://dx.doi.org/10.3332/ecancer.2020.1012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7105339PMC
February 2020

Pseudothrombocytopenia by ethylenediaminetetraacetic acid can jeopardize patient safety - report.

EJIFCC 2020 Mar 20;31(1):65-69. Epub 2020 Mar 20.

Servicio de Análisis Clinicos, Hospital Álvaro Cunqueiro, Vigo, Spain.

Pseudothrombocytopenia by ethylenediaminetetraacetic acid (EDTA) is an infrequent phenomenon of platelet agglutination due to the presence of antiplatelet autoantibodies. It has no clinical significance, but misdiagnosis may lead to clinical or therapeutic decision-making. In this study we report a case of an 8-year-old boy with no history of platelet disorder presenting a low platelet count and a peripheral blood smear showing clumping of platelets by EDTA. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7109506PMC

Immune thrombocytopenic purpura risk by live, inactivated and simultaneous vaccinations among Japanese adults, children and infants: a matched case-control study.

Int J Hematol 2020 Apr 6. Epub 2020 Apr 6.

Department of Health Sciences, University of Yamanashi, 1110 Shimokato, Chuo, Yamanashi, 409-3898, Japan.

This case-control study investigated immune thrombocytopenic purpura (ITP) risk following live, inactivated, and simultaneous vaccination, with a focus on infants aged < 2 years. We matched case patients with ITP to one or two control patients with other diseases by institution, hospital visit timing, sex, and age. We calculated McNemar's pairwise odds ratios (ORs [95% confidence interval]) with 114 case-control pairs. Read More

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http://dx.doi.org/10.1007/s12185-020-02866-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7223876PMC

HLA loci predisposing to immune TTP in Japanese: potential role of the shared ADAMTS13 peptide bound to different HLA-DR.

Blood 2020 Apr 6. Epub 2020 Apr 6.

Nara Medical University, Kashihara, Japan.

Immune-mediated thrombotic thrombocytopenic purpura (iTTP) is a rare autoimmune disorder caused by neutralizing anti-ADAMTS13 autoantibodies. In Caucasians, human leukocyte antigen (HLA) allele DRB1*11 was a predisposing factor for iTTP, while DRB1*04 was a protective factor. However, the role of HLA in Asians is unclear. Read More

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http://dx.doi.org/10.1182/blood.2020005395DOI Listing

Advances in the treatment of thrombotic thrombocytopenic purpura: repurposed drugs and novel agents.

Expert Rev Hematol 2020 May 10;13(5):461-470. Epub 2020 Apr 10.

Hematology Department, Universidad Autónoma de Nuevo León, Facultad de Medicina y Hospital Universitario 'Dr. José Eleuterio González', Monterrey, México.

: Thrombotic thrombocytopenic purpura (TTP) is an infrequent but fatal disease. Plasma exchange and corticosteroids continue to be the mainstay of treatment; however, repurposed drugs and novel agents are emerging as efficient treatment options.: In this review, new therapeutic developments in immune-mediated TTP including rituximab, bortezomib, -acetylcysteine, caplacizumab, and recombinant ADAMTS13, among others, are summarized. Read More

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http://dx.doi.org/10.1080/17474086.2020.1750361DOI Listing

Risk of systemic lupus erythematosus in patients with idiopathic thrombocytopenic purpura: a population-based cohort study.

Ann Rheum Dis 2020 Jun 2;79(6):793-799. Epub 2020 Apr 2.

Department of Rheumatology, BenQ Medical Center, The Affiliated BenQ Hospital of Nanjing Medical University, Nanjing, China

Background: Idiopathic thrombocytopenic purpura (ITP) may play a role in early-stage systemic lupus erythematosus (SLE). The incidence of SLE in patients with ITP and the potential relationship between them is still unclear. This study was performed to provide epidemiological evidence regarding the relationship between ITP and SLE occurrence. Read More

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http://dx.doi.org/10.1136/annrheumdis-2020-217013DOI Listing