988 results match your criteria Immune Thrombocytopenia and Pregnancy


Immune thrombocytopenia flare with mild COVID-19 infection in pregnancy: A case report.

Br J Haematol 2020 08 30;190(3):e146-e148. Epub 2020 Jun 30.

Haematology Department, Northwick Park Hospital, UK.

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http://dx.doi.org/10.1111/bjh.16928DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7300661PMC

Non-primary CMV infection not always innocent. A case-report and literature review.

Acta Clin Belg 2020 Jun 3:1-5. Epub 2020 Jun 3.

Department of Neonatology, Antwerp University Hospital, University of Antwerp , Belgium.

Objectives: Cytomegalovirus (CMV) is the most common infectious cause of congenital malformations. CMV infections are frequently symptomatic in case of a primary infection during pregnancy. Generally, maternal immunity protects the newborn against a symptomatic course of the CMV infection. Read More

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http://dx.doi.org/10.1080/17843286.2020.1773651DOI Listing

Immune thrombocytopenia due to COVID-19 during pregnancy.

Am J Hematol 2020 08 11;95(8):E191-E192. Epub 2020 Jun 11.

Department of Clinical Hematology, Amsterdam University Medical Center, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1002/ajh.25877DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7283860PMC

Romiplostim for management of refractory immune thrombocytopenic purpura in the immediate postpartum period.

BMJ Case Rep 2020 May 18;13(5). Epub 2020 May 18.

Department of OB/GYN, Trinity Health of New England, Hartford, Connecticut, USA

We present a case of a pregnant woman with chronic immune thrombocytopenic purpura and chronic hypertension who developed pre-eclampsia with severe features warranting delivery. Her overall clinical picture and liver enzymes improved in the immediate postpartum period, however, aggressively progressing thrombocytopenia posed a diagnostic dilemma to the interdisciplinary care team. After failing to respond to first-line therapies including high-dose corticosteroids and intravenous immunoglobulin, she was successfully managed with a trial of the thrombopoietin receptor agonist, Romiplostim. Read More

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http://dx.doi.org/10.1136/bcr-2020-234335DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7239498PMC

Comparative Study of the Clinical Application of 2 Bleeding Grading Systems for Pregnant Women With Immune Thrombocytopenia.

Clin Appl Thromb Hemost 2020 Jan-Dec;26:1076029620910790

Department of Haematology, Fujian Institute of Haematology, Fujian Provincial Key Laboratory on Haematology, Fujian Medical University Union Hospital, Fuzhou, Fujian Province, China.

To compare the clinical practicability of two bleeding grading systems (BGS) in pregnancy with Immune Thrombocytopenia (ITP). The clinical data of 154 cases were retrospectively analyzed with the 2016 version of the ITP Bleeding Scale (ITP-2016) and the ITP-specific bleeding assessment tool (ITP-BAT). The correlation between the two BGS and the relations among the platelet counts, gestational ages, and disease stages were respectively analyzed. Read More

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http://dx.doi.org/10.1177/1076029620910790DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7370566PMC

Research progress in relation of infection with pregnancy-related diseases and adverse pregnancy outcomes.

Authors:
Bai Zhou Fen Wang

Zhong Nan Da Xue Xue Bao Yi Xue Ban 2020 Mar;45(3):338-344

Depatment of Gastroenterology, Third Xiangya Hospital, Central South University, Changsha 410013

() is a Gram-negative microaerobic bacterium, which is parasitic on gastric mucosa and is associated with the pathogenesis of chronic gastritis, gastric ulcer, gastric cancer and other gastric diseases. Meanwhile, the infection is related with pregnancy-related diseases, pregnancy outcomes, and the health status of offspring, such as infertility, premature delivery, abortion, infection of newborn and neural tube defects. infection is also related to hyperemesis of pregnancy, preeclampsia, gestational diabetes mellitus, iron deficiency anemia, idiopathic thrombocytopenic purpura. Read More

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http://dx.doi.org/10.11817/j.issn.1672-7347.2020.190032DOI Listing

Thrombotic thrombocytopenic purpura with Graves' disease during pregnancy.

Proc (Bayl Univ Med Cent) 2020 Apr 23;33(2):270-272. Epub 2020 Jan 23.

Department of Pathology, Baylor University Medical CenterDallasTexas.

Thrombotic thrombocytopenic purpura may be seen with several autoimmune disorders such as immune thrombocytopenia purpura, immune hemolytic anemia, and systemic lupus erythematosus, but it is rarely associated with Graves' disease. We report a patient with thrombotic thrombocytopenic purpura associated with Graves' disease. Read More

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http://dx.doi.org/10.1080/08998280.2020.1713029DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7155955PMC

Use of romiplostim in pregnancy for refractory idiopathic thrombocytopenic purpura: Two case reports with maternal and fetal outcomes and literature review.

Obstet Med 2020 Mar 29;13(1):45-50. Epub 2018 May 29.

Lyell McEwin Hospital, Elizabeth Vale, Australia.

Idiopathic thrombocytopenic purpura is a relatively rare complication occurring in pregnancy, with the potential for serious maternal and fetal outcomes. Rarely, the poor response to established first-line therapies results in consideration of second-line therapies, which may have poorly understood risks to the fetus. We report two women with severe idiopathic thrombocytopenic purpura during pregnancy unresponsive to corticosteroids and intravenous immunoglobulin who were treated with romiplostim, a thrombopoietin receptor agonist. Read More

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http://dx.doi.org/10.1177/1753495X18773960DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7133099PMC

Thrombocytopenia in Pregnancy: Approach to Diagnosis and Management.

Semin Thromb Hemost 2020 Apr 7;46(3):256-263. Epub 2020 Apr 7.

Division of Hematology/Oncology, Department of Medicine, Mass General Cancer Center, Massachusetts General Hospital, Boston, Massachusetts.

The impact of thrombocytopenia varies widely depending on the underlying pathophysiology driving it. The biggest challenge in managing thrombocytopenia in pregnancy is accurately identifying the responsible pathophysiology-a task made difficult given the tremendous overlap in clinical and laboratory abnormalities associated with different thrombocytopenia processes. The most common etiologies of thrombocytopenia in pregnancy range from physiology deemed benign to those that are life-threatening to the mother and fetus. Read More

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http://dx.doi.org/10.1055/s-0040-1708842DOI Listing

Multidrug Therapy for Refractory Immune Thrombocytopenia in Pregnancy.

Obstet Gynecol 2020 Mar;135(3):723-727

Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, and the Division of Pediatric Hematology/Oncology and the Division of Allergy-Immunology, Department of Pediatrics, LAC+USC Medical Center, the Division of Neonatal Medicine, LAC+USC, and the Jane Anne Nohl Division of Hematology, Department of Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California.

Background: Severe immune thrombocytopenia complicating pregnancy may require treatment beyond first-line medications (intravenous immunoglobulins or corticosteroids), but there is a paucity of literature on the use of such second-line agents in pregnancy.

Case: The patient is a 29-year-old woman with early-onset severe immune thrombocytopenia at 13 weeks of gestation. Maternal platelet counts reached a nadir of less than 5×10/L. Read More

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http://dx.doi.org/10.1097/AOG.0000000000003699DOI Listing

Bromocriptine use for sudden peripartum cardiomyopathy in a patient with preeclampsia: a case report.

JA Clin Rep 2019 Jun 7;5(1):38. Epub 2019 Jun 7.

Department of Anesthesiology, Kansai Medical University Hospital, 2-3-1 Shin-machi, Hirakata, Osaka, 573-1191, Japan.

Background: Peripartum cardiomyopathy is an uncommon form of heart failure that occurs in otherwise healthy women during pregnancy or until 5 months postpartum. Here, we report a rare case where a female patient underwent cesarean section after the occurrence of preeclampsia and intrauterine fetal death, and developed peripartum cardiomyopathy following postsurgical respiratory distress. The prompt initiation of inotropic drug and bromocriptine therapy quickly restored cardiac function. Read More

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http://dx.doi.org/10.1186/s40981-019-0256-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6966983PMC

[How I treat primary immune thrombocytopenia in pregnancy].

Authors:
L Wang M Hou

Zhonghua Xue Ye Xue Za Zhi 2019 Dec;40(12):977-979

Department of Hematology, Qilu Hospital, Shandong University, Jinan 250012, China.

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http://dx.doi.org/10.3760/cma.j.issn.0253-2727.2019.12.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7342684PMC
December 2019

[Program for clinical care of immune thrombocytopenic purpura in pregnancy].

Lakartidningen 2020 01 23;117. Epub 2020 Jan 23.

Clintec, Karolinska Institutet - Obstetrics and Gynecology, Karolinska Sjukhuset Huddinge, Sweden Clintec - Obstetrics and Gynecology Huddinge, Sweden.

A program for care of women with immune thrombocytopenic purpura (ITP) with the recommendation to avoid treatment if platelets were >20 × 109/l during pregnancy, with the target level 100 × 109/l at delivery, was introduced. Treatment should be given with intravenous immunoglobulin (IVIG) or corticosteroids. Out of 75 pregnancies with ITP, 39 percent were treated and the treatment period was shorter with IVIG. Read More

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January 2020

Evans Syndrome and pregnancy: A case report with literature review.

J Pak Med Assoc 2019 Jul;69(7):1047-1048

Multan Institute of Nuclear Medicine and Radiotherapy (MINAR) Cancer Hospital, Multan, Pakistan.

Evans syndrome is a rare autoimmune disease in which an individual's antibodies attacks the body's own red blood cells and platelets.1 There is a coexistence of Immune thrombocytopenia (ITP) with Autoimmune haemolytic anaemia (AIHA) and both of these events may occur simultaneously or one follows the other. 2 Association of Evans syndrome with pregnancy is very rare, and only a few cases have been published in medical literature. Read More

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5 Years' Experience of a Tertiary Center with Thrombocytopenic Pregnancies: Gestational Thrombocytopenia, Idiopathic Thrombocytopenic Purpura and Hypertensive Disorders of Pregnancy.

Geburtshilfe Frauenheilkd 2020 Jan 24;80(1):76-83. Epub 2019 Jul 24.

Division of Perinatology, Department of Obstetrics and Gynecology, Hacettepe University, Ankara, Turkey.

To evaluate thrombocytopenic pregnancies including gestational thrombocytopenia (GT), idiopathic thrombocytopenic purpura (ITP), and hypertensive disorders of pregnancy (HDP). We evaluated the pregnancy outcomes and laboratory findings of 385 patients diagnosed with GT, ITP, or HDP whose thrombocyte levels were < 150 000/µL. GT, ITP, and HDP were the final diagnoses in 315 (81. Read More

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http://dx.doi.org/10.1055/a-0865-4442DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6957351PMC
January 2020

Prospects for risk stratification of anti-HPA-1a alloimmunized pregnant women.

Authors:
Ulrich J Sachs

Transfus Apher Sci 2020 Feb 31;59(1):102709. Epub 2019 Dec 31.

Institute for Clinical Immunology and Transfusion Medicine, Justus Liebig University, Giessen, Germany; Center for Transfusion Medicine and Hemotherapy, University Hospital Giessen and Marburg, Marburg, Germany; German Center for Fetomaternal Incompatibility (DZFI), University Hospital Giessen and Marburg, Giessen, Germany. Electronic address:

A diagnosis of fetal/neonatal alloimmune thrombocytopenia (FNAIT) is made if a platelet-specific antibody is detected in the mother and the fetus or newborn carries the cognate antigen. Some children will experience very low platelet counts or even intracranial hemorrhage with devastating consequences, whereas others are largely unaffected. At the moment, predictive tools to forecast the severity of FNAIT during pregnancy are not available and over- or under-treatment may put the mother or the fetus at risk. Read More

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http://dx.doi.org/10.1016/j.transci.2019.102709DOI Listing
February 2020

Acute immune trobocytopenic purpura in pregnant adolescent.

Ceska Gynekol 2019 ;84(6):443-449

Objective: The article reviews the causes of thrombocytopenia in pregnancy and the basic examination scheme. Further, it deals in more details with diagnosis of immune thromocytopenic purpura (ITP) and presents a case report of a rare case of acute severe ITP in pregnant adolescent.

Design: Review article and case report. Read More

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January 2020

Pregnancy and immune thrombocytopenia: New trends

J Turk Ger Gynecol Assoc 2020 06 13;21(2):136-137. Epub 2020 Jan 13.

Department of Hematology, Adnan Menderes University Medical Faculty, Aydın, Turkey

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http://dx.doi.org/10.4274/jtgga.galenos.2019.2019.0142DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7294828PMC

Severe Platelet Transfusion Refractoriness in Association with Antibodies Against CD36.

Lab Med 2020 Jan 11. Epub 2020 Jan 11.

The Platelet & Neutrophil Immunology Laboratory, Blood Center of Wisconsin (part of Versiti), Milwaukee, WI.

Platelet-transfusion refractoriness (PTR) is common in patients with hematological malignancies. The etiology of immune PTR is typically human leukocyte antigen (HLA) antibodies (Abs) from pregnancy or previous transfusion. Herein, we report PTR in the setting of induction chemotherapy for acute myelogenous leukemia (AML) from Abs against CD36/glycoprotein (GP)IV. Read More

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http://dx.doi.org/10.1093/labmed/lmz091DOI Listing
January 2020

Foetal and neonatal alloimmune thrombocytopenia - The role of the HLA-DRB3*01:01 allele for HPA-1a-immunisation and foetal/neonatal outcome.

Transfus Apher Sci 2020 Feb 31;59(1):102707. Epub 2019 Dec 31.

Department of Laboratory Medicine, University Hospital of North Norway, Tromsø, Norway.

Foetal and neonatal alloimmune thrombocytopenia (FNAIT) is the platelet counterpart of haemolytic disease of the foetus and newborn. Among Caucasians, around 80 % of FNAIT cases and some of the most severe cases, are caused by alloantibodies against the human platelet antigen 1a (HPA-1a). For around 3 decades it has been known that almost all HPA-1a-immunised women are HLA-DRB3*01:01 positive. Read More

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http://dx.doi.org/10.1016/j.transci.2019.102707DOI Listing
February 2020

Management of immune thrombocytopenia in women: current standards and special considerations.

Expert Rev Hematol 2020 Feb 22;13(2):175-185. Epub 2020 Jan 22.

Hematology Project Foundation and Department of Hematology, S. Bortolo Hospital, Vicenza, Italy.

: Immune thrombocytopenia (ITP) is an acquired autoimmune disorder, with an incidence rate of 20-40/million adults/year and an estimated prevalence in women of childbearing age of 24.5/million.: Authors discuss management of ITP in pregnancy, treatment-related toxicity, delivery, neonatal thrombocytopenia and breastfeeding, and other women's specific issues. Read More

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http://dx.doi.org/10.1080/17474086.2020.1711729DOI Listing
February 2020

[Thrombocytopenia in pregnancy: a single-center retrospective analysis of 91 cases].

Rinsho Ketsueki 2019 ;60(11):1525-1531

Department of Hematology and Oncology, Hiroshima University Hospital.

Thrombocytopenia is a relatively common complication in pregnancy, with a reported frequency of 7%-11%. The causes of this condition are diverse, although the most common etiology is gestational thrombocytopenia (GT) (70%-80%), followed by HELLP syndrome and immune thrombocytopenia (ITP). To investigate the clinical features of thrombocytopenia during pregnancy, we conducted a retrospective analysis of 69 women at our center with 91 pregnancies in which the platelet count was below 100×10/l. Read More

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http://dx.doi.org/10.11406/rinketsu.60.1525DOI Listing
December 2019

Updated international consensus report on the investigation and management of primary immune thrombocytopenia.

Blood Adv 2019 11;3(22):3780-3817

Division of Hematology, Massachusetts General Hospital, Harvard Medical School, Boston, MA.

Over the last decade, there have been numerous developments and changes in treatment practices for the management of patients with immune thrombocytopenia (ITP). This article is an update of the International Consensus Report published in 2010. A critical review was performed to identify all relevant articles published between 2009 and 2018. Read More

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http://dx.doi.org/10.1182/bloodadvances.2019000812DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6880896PMC
November 2019

Thrombocytopenia in pregnancy: Diagnosis and approach to management.

Blood Rev 2020 Mar 6;40:100638. Epub 2019 Nov 6.

Departments of Pathology and Laboratory Medicine and Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.

Thrombocytopenia during pregnancy presents unique challenges for the hematologist. Obstetricians generally manage many of the pregnancy-specific etiologies, ranging from the benign (gestational thrombocytopenia) to the life-threatening (preeclampsia; hemolysis, elevated liver enzymes and low platelets syndrome; and acute fatty liver of pregnancy). However, hematologists may be consulted for atypical and severe presentations and to help manage non-pregnancy specific etiologies, including immune thrombocytopenia, thrombotic thrombocytopenic purpura, hemolytic uremic syndrome and antiphospholipid syndrome, among others, in which maternal and fetal risks must be considered. Read More

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http://dx.doi.org/10.1016/j.blre.2019.100638DOI Listing

Acute thrombocytopenia: picking a way through a paucity of platelets.

Br J Hosp Med (Lond) 2019 Sep;80(9):507-512

Professor of Transfusion Medicine, Department of Haematology, Churchill Hospital, Oxford University Hospitals NHS Trust, Oxford.

Thrombocytopenia is defined as a platelet count under 150x10/litre. It may be found as a bystander to other pathology or directly related to an underlying haematological condition. Apart from laboratory artefact, it should be treated seriously as it often reflects serious underlying disease. Read More

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http://www.magonlinelibrary.com/doi/10.12968/hmed.2019.80.9.
Publisher Site
http://dx.doi.org/10.12968/hmed.2019.80.9.507DOI Listing
September 2019
28 Reads

Long-term safety and efficacy of rituximab in 248 adults with immune thrombocytopenia: Results at 5 years from the French prospective registry ITP-ritux.

Am J Hematol 2019 12 8;94(12):1314-1324. Epub 2019 Oct 8.

Service de Médecine Interne, Centre National de Référence des Cytopénies Auto-Immunes de l'Adulte, Centre Hospitalier Universitaire Henri-Mondor, Assistance Publique-Hôpitaux de Paris, Université Paris Est Créteil, Créteil, France.

Rituximab is a second-line option in adults with immune thrombocytopenia (ITP), but the estimated 5-year response rate, only based on pooled retrospective data, is about 20%, and no studies have focused on long-term safety. We conducted a prospective multicenter registry of 248 adults with ITP treated with rituximab with 5 years of follow-up to assess its long-term safety and efficacy. The median follow-up was 68. Read More

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http://dx.doi.org/10.1002/ajh.25632DOI Listing
December 2019
9 Reads

When age is truly only a number: late diagnosis of von Willebrand disease type 2B in a 61-year-old woman.

Blood Coagul Fibrinolysis 2019 Oct;30(7):361-363

Rochester General Hospital, Rochester, New York, USA.

: von Willebrand disease (VWD) type 2B is a rare bleeding disorder, presenting with moderate-to-severe lifelong bleeding. We present the case of a 61-year-old woman who was misdiagnosed as immune thrombocytopenic purpura during her three pregnancies resulting in a delayed diagnosis of VWD type 2B. This genetically confirmed diagnosis resulted in testing and the establishment of the diagnosis in her otherwise asymptomatic adult son as well. Read More

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http://dx.doi.org/10.1097/MBC.0000000000000847DOI Listing
October 2019
3 Reads

Severe thrombocytopenia in pregnancy: a case series from west China.

Clin Exp Med 2019 Nov 28;19(4):495-503. Epub 2019 Aug 28.

Department of Obstetrics and Gynecology, West China Second University Hospital, Sichuan University, No. 20, 3rd Section, South Renmin Road, Chengdu, 610041, Sichuan, China.

Thrombocytopenia is the second most common hematological disease during pregnancy and is mainly caused by gestational thrombocytopenia, immune thrombocytopenia, or preeclampsia/HELLP syndrome. This study aims to investigate the causes and pregnancy outcomes of thrombocytopenia in pregnancies with platelet counts below 50 × 10/L. We retrospectively analyzed the pregnancies diagnosed with severe thrombocytopenia at a tertiary care center in western China between January 2009 and December 2017. Read More

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http://dx.doi.org/10.1007/s10238-019-00575-6DOI Listing
November 2019
3 Reads

A single-center investigational study of CD36 antigen deficiency and platelet alloantibody distribution in different populations in Northern China as well as platelet alloantibodies effect on pregnancy.

Clin Chim Acta 2019 Nov 14;498:68-75. Epub 2019 Aug 14.

Department of Blood Transfusion, Chinese PLA General Hospital, China. Electronic address:

Background: Platelet antibodies can lead to clinical diseases such as platelet transfusion refractoriness (PTR), fetal/neonatal alloimmune thrombocytopenia (FNAIT), etc. This study is aimed at understanding CD36 expression, platelet alloantibody distribution in different populations in Northern China, and effects of platelet alloantibodies on pregnancy.

Study Design And Methods: Whole blood samples of 612 subjects including hematological patients, pregnant women, and blood donors were collected at a single center, then CD36 expressions were determined, followed by platelet antibody screening and characterization of platelet antibody specificity. Read More

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http://dx.doi.org/10.1016/j.cca.2019.08.009DOI Listing
November 2019
2.824 Impact Factor

Immune Thrombocytopenic Purpura in Pregnancy.

Obstet Gynecol Surv 2019 Aug;74(8):490-496

Assistant Professor, Division of Maternal Fetal Medicine, Duke University, Durham, NC.

Importance: Immune thrombocytopenia purpura (ITP), an autoimmune disease characterized by destruction of platelets, is a hematological disorder that can present in both pregnant and nonpregnant patients. Although thrombocytopenia in pregnancy can be caused by more common pathologies such as gestational thrombocytopenia and preeclampsia, ITP can present initially during pregnancy, further complicating diagnosis. Management must be considerate of both the pregnancy itself and the fetus. Read More

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http://Insights.ovid.com/crossref?an=00006254-201908000-0001
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http://dx.doi.org/10.1097/OGX.0000000000000697DOI Listing
August 2019
2 Reads

Pregnancy of patients with idiopathic thrombocytopenic purpura: maternal and neonatal outcomes

J Turk Ger Gynecol Assoc 2020 06 9;21(2):97-101. Epub 2019 Aug 9.

Department of Obstetrics and Gynecology, Başkent University Faculty of Medicine, Adana Application and Research Hospital, Adana, Turkey

Objective: Thrombocytopenia occurs in 7% of pregnant women. Along with other causes, idiopathic thrombocytopenic purpura (ITP), which is an autoimmune disease with autoantibodies causing platelet destruction, must be considered in the differential diagnosis. Antiplatelet antibodies can cross the placenta and cause thrombocytopenia in the newborn. Read More

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http://cms.galenos.com.tr/Uploads/Article_29871/JTGGA-0-0-En
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http://dx.doi.org/10.4274/jtgga.galenos.2019.2019.0078DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7294835PMC
June 2020
4 Reads

Managing ITP and thrombocytopenia in pregnancy.

Platelets 2020 11;31(3):300-306. Epub 2019 Jul 11.

Clinical and Laboratory Haematologist, Obstetric Physician, National Women's Health, Auckland City Hospital, Auckland, New Zealand.

Around 1 in 10 pregnant women will develop thrombocytopenia during an otherwise unremarkable pregnancy. While the most frequent cause is gestational thrombocytopenia, a benign clinical entity which typically induces a mild platelet fall in late pregnancy, a number of important pregnancy-specific causes must be excluded, particularly pre-eclampsia and its severe form hemolysis with elevated liver enzymes and low platelets (HELLP). For women who do not have an identifiable pregnancy-related cause of thrombocytopenia, an underlying medical condition should be considered. Read More

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http://dx.doi.org/10.1080/09537104.2019.1640870DOI Listing
July 2019
5 Reads

[Gaucher Disease type 1 mimicking immune thrombocytopenia: Role of hyperferritinemia and hypergammaglobulinemia in the initial evaluation of an isolated thrombopenia].

Rev Med Interne 2019 Oct 15;40(10):680-683. Epub 2019 Jun 15.

Département de médecine interne, hôpital de la Timone, Aix-Marseille université, AP-HM, 264, rue St-Pierre, 13385 Marseille cedex 05, France.

Introduction: Gaucher disease type 1 is a rare genetic disease. It can cause thrombocytopenia. Current guidelines do not support bone marrow examination in front of isolated thrombocytopenia if no evidence suggests malignant hemopathy. Read More

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http://dx.doi.org/10.1016/j.revmed.2019.05.013DOI Listing
October 2019
5 Reads

Idiopathic thrombocytopenic purpura (ITP) - new era for an old disease.

Rom J Intern Med 2019 Dec;57(4):273-283

Hematology Clinic, Emergency University Hospital, Bucharest, Romania.

Immune thrombocytopenia is an autoimmune hematological disorder characterized by severely decreased platelet count of peripheral cause: platelet destruction via antiplatelet antibodies which may also affect marrow megakaryocytes. Patients may present in critical situations, with cutaneous and/or mucous bleeding and possibly life-threatening organ hemorrhages (cerebral, digestive, etc.) Therefore, rapid diagnosis and therapeutic intervention are mandatory. Read More

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http://dx.doi.org/10.2478/rjim-2019-0014DOI Listing
December 2019
11 Reads

Use of Romiplostim during pregnancy as a rescue therapy in primary immune thrombocytopenia: Literature review and case description.

Platelets 2020 22;31(3):403-406. Epub 2019 May 22.

Oncology Service, Oncología HM Sanchinarro, Madrid, Spain.

Thrombocytopenia could appear during pregnancy, in up to 8-10% of the cases, where 3-5% is related to an autoimmune process so-called immune thrombocytopenia (ITP). We present a 34-year-old woman debuted at 13 weeks gestation, with a platelet count of 19 × 10/L and petechiae. She did not respond to initial treatment with corticosteroids and intravenous immunoglobulin. Read More

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http://dx.doi.org/10.1080/09537104.2019.1615613DOI Listing
May 2019
11 Reads

Prenatal Management of Pregnancies at Risk of Fetal Neonatal Alloimmune Thrombocytopenia (FNAIT): Scientific Impact Paper No. 61.

BJOG 2019 09 9;126(10):e173-e185. Epub 2019 Apr 9.

WHAT IS IT?: Fetal neonatal alloimmune thrombocytopenia (FNAIT), also known as neonatal alloimmune thrombocytopenia (NAIT) or fetomaternal alloimmune thrombocytopenia (FMAIT), is a rare condition which affects a baby's platelets. This can put them at risk of problems with bleeding, particularly into the brain. One baby per week in the UK may be seriously affected and milder forms can affect one in every 1000 births. Read More

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http://dx.doi.org/10.1111/1471-0528.15642DOI Listing
September 2019
11 Reads

Fostamatinib (Tavalisse) for ITP.

Authors:

Med Lett Drugs Ther 2019 Feb;61(1566):28-30

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February 2019
17 Reads

Immune thrombocytopenic purpura.

J Community Hosp Intern Med Perspect 2019 11;9(1):59-61. Epub 2019 Feb 11.

Department of Medicine, Unity Hospital, Rochester Regional Health, Rochester, NY, USA.

Immune thrombocytopenic purpura (ITP) is a bleeding disorder characterized by isolated thrombocytopenia (platelet count <150,000 u/L), which is not associated with a systemic illness. ITP is reported in approximately 2 per 100,000 adults. The mean age of diagnosis is 50 years. Read More

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http://dx.doi.org/10.1080/20009666.2019.1565884DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6374974PMC
February 2019
14 Reads

[Establishment and one-year evaluation of an internal medicine consultation in a maternity].

Sante Publique 2018 September October;30(5):671-677

Objective: In the obstetric medicine movement and in response to requests for appointments in internal medicine by obstetricians and midwives, we created an internal medicine consultation within the maternity ward of our General Hospital, and provide feedback after 1 year.

Methods: This retrospective descriptive study took place at the Robert Ballanger Intercommunal Hospital Center in Aulnay-sous-Bois in Seine-Saint-Denis (France) between 3rd March 2016 and 9th March 2017, the first year of the internal medicine consultation, one afternoon every 15 days, in the maternity level 2b.

Results: Out of 121 appointments, 93 consultations were conducted for 63 patients. Read More

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http://dx.doi.org/10.3917/spub.186.0671DOI Listing
April 2019
11 Reads

Cryptic conspirators: a conversation about thrombocytopenia and antiphospholipid syndrome.

Curr Opin Rheumatol 2019 05;31(3):231-240

Division of Rheumatology, Department of Internal Medicine, University of Michigan.

Purpose Of Review: Although antiphospholipid syndrome (APS) is best known for conveying increased risk of thrombotic events and pregnancy morbidity, thrombocytopenia is also recognized as a common association. In this review, we will explore the relationship between thrombocytopenia and APS, highlighting our evolving understanding - and persistent knowledge gaps - through clinically oriented questions and answers.

Recent Findings: A history of thrombocytopenia likely portends a more severe APS phenotype (including increased risk of thrombosis). Read More

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http://dx.doi.org/10.1097/BOR.0000000000000595DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6455093PMC
May 2019
20 Reads

A Case of Pregnancy Complicated with Evans Syndrome with Sequential Development of Autoimmune Warm Antibody Hemolytic Anemia and Idiopathic Thrombocytopenic Purpura.

Case Rep Obstet Gynecol 2019 14;2019:2093612. Epub 2019 Jan 14.

Department of Obstetrics and Gynecology, Toyooka Public Hospital, 1094, Tobera, Toyooka City, Hyogo 6680065, Japan.

The simultaneous or sequential development of autoimmune hemolytic anemia (AIHA) and idiopathic thrombocytopenic purpura (ITP) is known as Evans syndrome. We experienced a case of Evans syndrome that developed AIHA during pregnancy and ITP long after delivery. The patient was a 35-year-old pregnant woman (gravida 2, para 1). Read More

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http://dx.doi.org/10.1155/2019/2093612DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6348819PMC
January 2019
12 Reads

Immune thrombocytopenic purpura presenting with spontaneous gingival haemorrhage in pregnancy.

BMJ Case Rep 2019 Jan 17;12(1). Epub 2019 Jan 17.

Department of Oral and Maxillofacial Surgery, The Queen Elizabeth Hospital, Birmingham, UK.

Gingival bleeding is a common intraoral finding, typically associated with inflamed tissues and periodontal disease. It is easily provoked by periodontal probing or toothbrushing. Spontaneous gingival bleeding rarely occurs and may be the only sign of systemic bleeding problems such as thrombocytopenia, leukaemia or coagulopathy. Read More

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http://dx.doi.org/10.1136/bcr-2018-228309DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6340514PMC
January 2019
26 Reads

Cerebral Venous Sinus Thrombosis in Systemic Lupus Erythematosus.

Acta Med Indones 2018 Oct;50(4):343-345

Department of Internal Medicine, Faculty of Medicine, Padjadjaran University, Bandung, Indonesia.

A 38-year-old woman presented with general weakness and vaginal bleeding. One month prior, she had been diagnosed with Evans syndrome (haemolytic anemia with positive Coombs test and thrombocytopenia) and was given oral steroid as maintenance therapy. Her serology examination was negative for hepatitis B, hepatitis C, and human immunodeficiency virus (HIV). Read More

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October 2018
51 Reads

[Refractory primary immune thrombocytopenia in pregnancy requiring splenectomy and repeated intravenous immunoglobulin therapy].

Rinsho Ketsueki 2018;59(12):2574-2577

Third Department of Internal Medicine, Yamaguchi University School of Medicine.

A 30-year-old primigravid woman without a history of thrombocytopenia was referred to our hospital because of severe thrombocytopenia (<1,000 thrombocytes/µl) at 16 weeks of gestation and diagnosed with idiopathic thrombocytopenic purpura (ITP). There was no improvement in the platelet count after treatment with 0.5-1. Read More

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https://www.jstage.jst.go.jp/article/rinketsu/59/12/59_2574/
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http://dx.doi.org/10.11406/rinketsu.59.2574DOI Listing
July 2019
33 Reads

Circulating antiplatelet antibodies in pregnant women with immune thrombocytopenic purpura as predictors of thrombocytopenia in the newborns.

Platelets 2019 7;30(8):1008-1012. Epub 2019 Jan 7.

National Medical Research Center for Cardiology, Ministry of Health , Moscow , Russian Federation.

Newborns from mothers with immune thrombocytopenic purpura (ITP) have a risk of thrombocytopenia due to passage of maternal antiplatelet antibodies into fetal/neonatal circulation. We looked for predictors of neonatal thrombocytopenia (nTP) in pregnant women with ITP. One hundred pregnant women with platelet count <100 × 10/l, no non-immune causes of thrombocytopenia and increased platelet associated IgG (PA-IgG) were included in the study. Read More

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https://www.tandfonline.com/doi/full/10.1080/09537104.2018.1
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http://dx.doi.org/10.1080/09537104.2018.1557615DOI Listing
February 2020
36 Reads

Effect of recombinant human thrombopoietin on immune thrombocytopenia in pregnancy in a murine model.

Int Immunopharmacol 2019 Feb 17;67:287-293. Epub 2018 Dec 17.

Department of Hematology, Qilu Hospital, Shandong University, Jinan, China; Shandong Provincial Key Laboratory of Immunohematology, Qilu Hospital, Shandong University, Jinan, China; Leading Research Group of Scientific Innovation, Department of Science and Technology of Shandong Province, Qilu Hospital, Shandong University, Jinan, China. Electronic address:

Primary immune thrombocytopenia (ITP) is a serious medical disorder that has the potential for maternal and fetal mortality. Corticosteroids, intravenous immunoglobulin, or both are the first-line treatments for ITP in pregnancy, but choices are limited if patients fail to respond. Recombinant human thrombopoietin (rhTPO) has been proved effective and safe in management of chronic ITP. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S15675769183046
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http://dx.doi.org/10.1016/j.intimp.2018.12.032DOI Listing
February 2019
44 Reads

Clinical usefulness of serum levels of soluble fms-like tyrosine kinase 1/placental growth factor ratio to rule out preeclampsia in women with new-onset lupus nephritis during pregnancy.

CEN Case Rep 2019 05 18;8(2):95-100. Epub 2018 Dec 18.

Department of Obstetrics and Gynecology, Jichi Medical University School of Medicine, 3311-1 Yakushiji, Shimotsuke, 329-0498, Japan.

Measurement of the soluble fms-like tyrosine kinase 1 (sFlt-1)/placental growth factor (PlGF) ratio may be clinically useful to discriminate systemic lupus erythematosus (SLE) from preeclampsia. Here, we present a pregnant woman with new-onset SLE with hypertension, with the measurement of the sFlt-1/PlGF ratio during pregnancy. A 31-year-old Japanese nulliparous woman, who had been diagnosed with idiopathic thrombocytopenic purpura at 10 years, had a systolic blood pressure of 120 mmHg and was negative for proteinuria at 12 weeks. Read More

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http://dx.doi.org/10.1007/s13730-018-0373-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6450983PMC
May 2019
15 Reads

Presence of Immune Complexes of IgG/IgM Bound to B2-glycoprotein I Is Associated With Non-criteria Clinical Manifestations in Patients With Antiphospholipid Syndrome.

Front Immunol 2018 20;9:2644. Epub 2018 Nov 20.

Immunology Department, Hospital 12 de Octubre, Madrid, Spain.

Antiphospholipid syndrome (APS) is an acquired autoimmune disorder defined by the presence of both clinical (thromboembolic events or pregnancy morbidity) and laboratory (antiphospholipid antibodies, aPL) manifestations. Despite their importance, several clinical manifestations strongly associated with APS such as livedo reticularis (LR), thrombocytopenia, sicca-ophthalmic(sicca), heart, or neurological manifestations are not included in the APS clinical classification criteria. Circulating immune complexes (CIC) formed by Beta-2-glycoprotein I (B2GPI) and aPL (B2-CIC) have been described and their presence has been related with thrombotic events. Read More

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http://dx.doi.org/10.3389/fimmu.2018.02644DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6256181PMC
October 2019
50 Reads