945 results match your criteria Immune Thrombocytopenia and Pregnancy


Fostamatinib (Tavalisse) for ITP.

Authors:

Med Lett Drugs Ther 2019 Feb;61(1566):28-30

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February 2019
4 Reads

Immune thrombocytopenic purpura.

J Community Hosp Intern Med Perspect 2019 11;9(1):59-61. Epub 2019 Feb 11.

Department of Medicine, Unity Hospital, Rochester Regional Health, Rochester, NY, USA.

Immune thrombocytopenic purpura (ITP) is a bleeding disorder characterized by isolated thrombocytopenia (platelet count <150,000 u/L), which is not associated with a systemic illness. ITP is reported in approximately 2 per 100,000 adults. The mean age of diagnosis is 50 years. Read More

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http://dx.doi.org/10.1080/20009666.2019.1565884DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6374974PMC
February 2019
3 Reads

[Establishment and one-year evaluation of an internal medicine consultation in a maternity].

Sante Publique 2018 September October;30(5):671-677

Objective: In the obstetric medicine movement and in response to requests for appointments in internal medicine by obstetricians and midwives, we created an internal medicine consultation within the maternity ward of our General Hospital, and provide feedback after 1 year.

Methods: This retrospective descriptive study took place at the Robert Ballanger Intercommunal Hospital Center in Aulnay-sous-Bois in Seine-Saint-Denis (France) between 3rd March 2016 and 9th March 2017, the first year of the internal medicine consultation, one afternoon every 15 days, in the maternity level 2b.

Results: Out of 121 appointments, 93 consultations were conducted for 63 patients. Read More

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http://dx.doi.org/10.3917/spub.186.0671DOI Listing
February 2019
1 Read

Cryptic conspirators: a conversation about thrombocytopenia and antiphospholipid syndrome.

Curr Opin Rheumatol 2019 Mar 1. Epub 2019 Mar 1.

Division of Rheumatology, Department of Internal Medicine, University of Michigan.

Purpose Of Review: Although antiphospholipid syndrome (APS) is best known for conveying increased risk of thrombotic events and pregnancy morbidity, thrombocytopenia is also recognized as a common association. In this review, we will explore the relationship between thrombocytopenia and APS, highlighting our evolving understanding - and persistent knowledge gaps - through clinically oriented questions and answers.

Recent Findings: A history of thrombocytopenia likely portends a more severe APS phenotype (including increased risk of thrombosis). Read More

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http://dx.doi.org/10.1097/BOR.0000000000000595DOI Listing
March 2019
1 Read

A Case of Pregnancy Complicated with Evans Syndrome with Sequential Development of Autoimmune Warm Antibody Hemolytic Anemia and Idiopathic Thrombocytopenic Purpura.

Case Rep Obstet Gynecol 2019 14;2019:2093612. Epub 2019 Jan 14.

Department of Obstetrics and Gynecology, Toyooka Public Hospital, 1094, Tobera, Toyooka City, Hyogo 6680065, Japan.

The simultaneous or sequential development of autoimmune hemolytic anemia (AIHA) and idiopathic thrombocytopenic purpura (ITP) is known as Evans syndrome. We experienced a case of Evans syndrome that developed AIHA during pregnancy and ITP long after delivery. The patient was a 35-year-old pregnant woman (gravida 2, para 1). Read More

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http://dx.doi.org/10.1155/2019/2093612DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6348819PMC
January 2019
1 Read

Immune thrombocytopenic purpura presenting with spontaneous gingival haemorrhage in pregnancy.

BMJ Case Rep 2019 Jan 17;12(1). Epub 2019 Jan 17.

Department of Oral and Maxillofacial Surgery, The Queen Elizabeth Hospital, Birmingham, UK.

Gingival bleeding is a common intraoral finding, typically associated with inflamed tissues and periodontal disease. It is easily provoked by periodontal probing or toothbrushing. Spontaneous gingival bleeding rarely occurs and may be the only sign of systemic bleeding problems such as thrombocytopenia, leukaemia or coagulopathy. Read More

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http://dx.doi.org/10.1136/bcr-2018-228309DOI Listing
January 2019
15 Reads

Cerebral Venous Sinus Thrombosis in Systemic Lupus Erythematosus.

Acta Med Indones 2018 Oct;50(4):343-345

Department of Internal Medicine, Faculty of Medicine, Padjadjaran University, Bandung, Indonesia.

A 38-year-old woman presented with general weakness and vaginal bleeding. One month prior, she had been diagnosed with Evans syndrome (haemolytic anemia with positive Coombs test and thrombocytopenia) and was given oral steroid as maintenance therapy. Her serology examination was negative for hepatitis B, hepatitis C, and human immunodeficiency virus (HIV). Read More

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October 2018
10 Reads

[Refractory primary immune thrombocytopenia in pregnancy requiring splenectomy and repeated intravenous immunoglobulin therapy].

Rinsho Ketsueki 2018 ;59(12):2574-2577

Third Department of Internal Medicine, Yamaguchi University School of Medicine.

A 30-year-old primigravid woman without a history of thrombocytopenia was referred to our hospital because of severe thrombocytopenia (<1,000 thrombocytes/µl) at 16 weeks of gestation and diagnosed with idiopathic thrombocytopenic purpura (ITP). There was no improvement in the platelet count after treatment with 0.5-1. Read More

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https://www.jstage.jst.go.jp/article/rinketsu/59/12/59_2574/
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http://dx.doi.org/10.11406/rinketsu.59.2574DOI Listing
January 2018
10 Reads

Circulating antiplatelet antibodies in pregnant women with immune thrombocytopenic purpura as predictors of thrombocytopenia in the newborns.

Platelets 2019 Jan 7:1-5. Epub 2019 Jan 7.

a National Medical Research Center for Cardiology , Ministry of Health , Moscow , Russian Federation.

Newborns from mothers with immune thrombocytopenic purpura (ITP) have a risk of thrombocytopenia due to passage of maternal antiplatelet antibodies into fetal/neonatal circulation. We looked for predictors of neonatal thrombocytopenia (nTP) in pregnant women with ITP. One hundred pregnant women with platelet count <100 × 10/l, no non-immune causes of thrombocytopenia and increased platelet associated IgG (PA-IgG) were included in the study. Read More

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https://www.tandfonline.com/doi/full/10.1080/09537104.2018.1
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http://dx.doi.org/10.1080/09537104.2018.1557615DOI Listing
January 2019
10 Reads

Effect of recombinant human thrombopoietin on immune thrombocytopenia in pregnancy in a murine model.

Int Immunopharmacol 2019 Feb 17;67:287-293. Epub 2018 Dec 17.

Department of Hematology, Qilu Hospital, Shandong University, Jinan, China; Shandong Provincial Key Laboratory of Immunohematology, Qilu Hospital, Shandong University, Jinan, China; Leading Research Group of Scientific Innovation, Department of Science and Technology of Shandong Province, Qilu Hospital, Shandong University, Jinan, China. Electronic address:

Primary immune thrombocytopenia (ITP) is a serious medical disorder that has the potential for maternal and fetal mortality. Corticosteroids, intravenous immunoglobulin, or both are the first-line treatments for ITP in pregnancy, but choices are limited if patients fail to respond. Recombinant human thrombopoietin (rhTPO) has been proved effective and safe in management of chronic ITP. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S15675769183046
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http://dx.doi.org/10.1016/j.intimp.2018.12.032DOI Listing
February 2019
9 Reads

Clinical usefulness of serum levels of soluble fms-like tyrosine kinase 1/placental growth factor ratio to rule out preeclampsia in women with new-onset lupus nephritis during pregnancy.

CEN Case Rep 2018 Dec 18. Epub 2018 Dec 18.

Department of Obstetrics and Gynecology, Jichi Medical University School of Medicine, 3311-1 Yakushiji, Shimotsuke, 329-0498, Japan.

Measurement of the soluble fms-like tyrosine kinase 1 (sFlt-1)/placental growth factor (PlGF) ratio may be clinically useful to discriminate systemic lupus erythematosus (SLE) from preeclampsia. Here, we present a pregnant woman with new-onset SLE with hypertension, with the measurement of the sFlt-1/PlGF ratio during pregnancy. A 31-year-old Japanese nulliparous woman, who had been diagnosed with idiopathic thrombocytopenic purpura at 10 years, had a systolic blood pressure of 120 mmHg and was negative for proteinuria at 12 weeks. Read More

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http://dx.doi.org/10.1007/s13730-018-0373-7DOI Listing
December 2018
4 Reads

Presence of Immune Complexes of IgG/IgM Bound to B2-glycoprotein I Is Associated With Non-criteria Clinical Manifestations in Patients With Antiphospholipid Syndrome.

Front Immunol 2018 20;9:2644. Epub 2018 Nov 20.

Immunology Department, Hospital 12 de Octubre, Madrid, Spain.

Antiphospholipid syndrome (APS) is an acquired autoimmune disorder defined by the presence of both clinical (thromboembolic events or pregnancy morbidity) and laboratory (antiphospholipid antibodies, aPL) manifestations. Despite their importance, several clinical manifestations strongly associated with APS such as livedo reticularis (LR), thrombocytopenia, sicca-ophthalmic(sicca), heart, or neurological manifestations are not included in the APS clinical classification criteria. Circulating immune complexes (CIC) formed by Beta-2-glycoprotein I (B2GPI) and aPL (B2-CIC) have been described and their presence has been related with thrombotic events. Read More

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http://dx.doi.org/10.3389/fimmu.2018.02644DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6256181PMC
November 2018
15 Reads

Refractory Severe Thrombocytopenia during Pregnancy: How to Manage.

Rev Bras Ginecol Obstet 2018 Dec 7;40(12):803-807. Epub 2018 Dec 7.

Department of Anaesthesiology, Centro Hospitalar Lisboa Norte, Lisboa, Portugal.

Thrombocytopenia is the most common hemostatic change in pregnancy, but severe thrombocytopenia is rare. One of the causes, immune thrombocytopenic purpura (ITP), is characterized by increased platelet destruction by immunoglobulin G (IgG) antibodies, presenting a high risk of hemorrhage for the patient, but also for the fetus, since antibodies may cross the placenta. We present the case of a 23-year-old pregnant woman with a history of Langerhans cell histiocytosis of the mandible submitted to surgery and chemotherapy when she was 10 years old, with diagnosis of ITP since then. Read More

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http://dx.doi.org/10.1055/s-0038-1675186DOI Listing
December 2018
5 Reads

Clinical characteristics, neonatal risk and recurrence rate of gestational thrombocytopenia with platelet count <100 × 10/L.

Eur J Obstet Gynecol Reprod Biol 2018 Dec 10;231:75-79. Epub 2018 Oct 10.

Hematology Department, Hadassah-Hebrew University Medical Center, Jerusalem, Israel. Electronic address:

Objective: Gestational thrombocytopenia (GT) accounts for 75% of cases of thrombocytopenia in pregnancy. In most cases of GT, thrombocytopenia is mild (100-150 × 10/L) and has no consequences for either the mother or the fetus. We aimed to investigate the characteristics, neonatal risk and recurrence rate of GT with a platelet count <100 × 10/L. Read More

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http://dx.doi.org/10.1016/j.ejogrb.2018.10.026DOI Listing
December 2018
14 Reads

Risk factors associated with neonatal thrombocytopenia in pregnant women with immune thrombocytopenic purpura.

J Matern Fetal Neonatal Med 2018 Nov 4:1-7. Epub 2018 Nov 4.

b Hematology Department , Hadassah, Hebrew University Medical Center , Jerusalem , Israel.

Objectives: To characterize the risk factors associated with neonatal thrombocytopenia among pregnant women with immune thrombocytopenic purpura (ITP).

Methods: We reviewed the records of ITP patients who delivered during 2006-2016 at our medical center.

Results: Of 253 pregnancies, median maternal age at diagnosis was 29 [25-33] years, 222 (87. Read More

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http://dx.doi.org/10.1080/14767058.2018.1523891DOI Listing
November 2018
5 Reads

Microangiopathic Hemolytic Anemia in Pregnancy.

Transfus Med Rev 2018 10 18;32(4):230-236. Epub 2018 Aug 18.

Department of Haematology, UCLH, Cardiometabolic Programme NIHR UCLH/UCL BRC, London, UK. Electronic address:

Thrombotic microangiopathies (TMAs) are associated with microangiopathic hemolytic anemia and thrombocytopenia, resulting in microvascular thrombosis and end-organ damage. In pregnancy, this may be the result of pregnancy-related TMAs such as preeclampsia; hemolysis, elevated liver enzymes, and low platelets; or pregnancy-associated TMAs, specifically thrombotic thrombocytopenic purpura (TTP) or complement-mediated hemolytic uremic syndrome (CM HUS). TTP and CM HUS are rare disorders, and their diagnosis may be missed, no less because features at presentation may be misdiagnosed as a pregnancy-related TMA, such as hypertension, proteinuria, fetal growth restriction, or in utero fetal death. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S08877963183006
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http://dx.doi.org/10.1016/j.tmrv.2018.08.002DOI Listing
October 2018
20 Reads

Autoimmune cytopenias and thrombotic thrombocytopenic purpura.

Clin Med (Lond) 2018 Aug;18(4):335-339

Oxford University Hospitals NHS Foundation Trust, Oxford, UK

The autoimmune cytopenias are a group of disorders resulting primarily from autoantibody-mediated destruction of blood cells, with variable clinical sequelae depending on the severity and lineage affected. Disease presentation ranges from an asymptomatic finding on a routine full blood count to an acutely unwell patient suffering the clinical consequences of severe anaemia, neutropenia or thrombocytopenia. The cytopenia may be primary or secondary to underlying infectious, immune or malignant processes. Read More

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http://dx.doi.org/10.7861/clinmedicine.18-4-335DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6334040PMC
August 2018
4 Reads

Neonates born to mothers with immune thrombocytopenia: 11 years experience of a single academic center.

Blood Coagul Fibrinolysis 2018 Sep;29(6):546-550

Department of Neonatology.

: A major problem associated with immune thrombocytopenic purpura (ITP) in pregnancy is neonatal thrombocytopenia. We analyzed newborns born to mothers with ITP and examined predictive factors for thrombocytopenia. This retrospective study was performed in a single academic center from January 2007 to January 2018. Read More

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http://dx.doi.org/10.1097/MBC.0000000000000758DOI Listing
September 2018
9 Reads

Evaluation of glucocorticoid compared with immunoglobulin therapy of severe immune thrombocytopenia during pregnancy: Response rate and complication.

Am J Reprod Immunol 2018 Oct 16;80(4):e13000. Epub 2018 Jul 16.

Hematology, Peking University People's Hospital, Beijing, China.

Problem: Evaluate the response rate of glucocorticoid (GC) and/or immunoglobulin (IVIg) therapy in severe thrombocytopenia of immune thrombocytopenia (ITP) pregnant patients and the influence on maternal and neonatal outcomes.

Method Of Study: This is a prospective observational cohort study. Pregnant ITP patients with platelet count less than 30 × 10 /L and their newborn infants participated in this research. Read More

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http://doi.wiley.com/10.1111/aji.13000
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http://dx.doi.org/10.1111/aji.13000DOI Listing
October 2018
20 Reads

Coexistence of Kasabach-Merritt Syndrome and placental chorioangioma in a premature infant.

J Neonatal Perinatal Med 2018 ;11(2):209-213

Kasabach-Merritt syndrome is a rare life-threatening clinical presentation in neonatal period. it is characterized by giant hemangioma and serious thrombocytopenia. The diagnostic criteria include: 1) hemangiomas on skin, 2) thrombocytopenia or coagulopathy, 3) hemangioma on internal organs diagnosed by ultrasonography, computed tomography or magnetic resonance imaging, and 4) excluding reasons, such as idiopathic thrombocytopenic purpura or hypersplenism. Read More

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http://dx.doi.org/10.3233/NPM-181754DOI Listing
December 2018
21 Reads

Severe immune thrombocytopenia in pregnancy treated with Eltrombopag - A case report.

J Gynecol Obstet Hum Reprod 2018 Oct 4;47(8):405-408. Epub 2018 Jul 4.

Obstetrics Department, Centro Hospitalar e Universitário de Coimbra, Coimbra, Portugal.

Immune thrombocytopenia (ITP) during pregnancy is an acquired autoimmune disease present in 1-2 of every 1000 pregnancies. Thrombopoietin (TPO)-mimetic drugs, such as eltrombopag, have been successfully used for treatment of ITP during pregnancy, but studies regarding its safety during gestation are lacking. A 33-year-old nulliparous woman with a history of chronic ITP, presented at the emergency department with petechiae, epistaxis, bruises, conjunctival effusions and a platelet count of 3×10/L at 25 weeks gestation. Read More

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http://dx.doi.org/10.1016/j.jogoh.2018.06.010DOI Listing
October 2018
3 Reads

Two potentially lethal conditions of probable immune origin occurring in a pregnant woman: a case report.

J Med Case Rep 2018 Jun 6;12(1):158. Epub 2018 Jun 6.

University Obstetrics Unit, De Soysa Hospital for Women, Colombo, Sri Lanka.

Background: Thrombotic thrombocytopenic purpura and peripartum cardiomyopathy are potentially lethal complications of pregnancy. We describe a case in which both of these developed in the same patient. The etiologies of both conditions remain uncertain, but they share immune hyperreactivity as a possible cause. Read More

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http://dx.doi.org/10.1186/s13256-018-1701-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5989333PMC
June 2018
9 Reads

Post-Partum Thrombotic Thrombocytopenic Purpura (TTP) in a Patient with known Idiopathic (Immune) Thrombocytopenic Purpura: a case report and review of the literature.

J Med Case Rep 2018 Jun 1;12(1):147. Epub 2018 Jun 1.

Faculty of Medicine, University of Jordan and Jordan University Hospital, PO Box 2194, Amman, 11941, Jordan.

Background: Incidences of immune thrombocytopenic purpura occur in 1 in every 1000-10,000 pregnancies accounting for 3% of all thrombocytopenic pregnancies. A pre-existing immune thrombocytopenic purpura is known to be a risk factor for developing thrombocytopenia during pregnancy. We present here the treatment regime and management of a patient with known immune thrombocytopenic purpura who developed postpartum thrombotic thrombocytopenia with atypical response to traditional therapy. Read More

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http://dx.doi.org/10.1186/s13256-018-1692-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5984346PMC
June 2018
10 Reads

[Interpretation of the Guidance for Immune Thrombocytopenia-Review].

Zhongguo Shi Yan Xue Ye Xue Za Zhi 2018 Apr;26(2):621-625

Department of Hematology, Xiangya Hospital of Central South University, Changsha 410008, Hunan Provincne, China; Department of Hematology, The Third Hospital of Xiangya Central South University, Changsha 410008, Hunan Provincne, China.

Since the American Medical Association published the 2011 guidelines for immune thrombocytopenia, China has been the first to update the guidelines for immune thrombocytopenia based on evidence-based medicine. Recently, there have been many breakthroughs in clinical research published, especially the Chinese medical workers have made a prominent contribution to the treatment of the immune thrombocytopenia. However, the references of systematic drug introduction for children, adults, aged and pregnant women are still insufficient, and the first or second line treatment for some patients were ineffective. Read More

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http://dx.doi.org/10.7534/j.issn.1009-2137.2018.02.053DOI Listing
April 2018
2 Reads

Refractory severe immune thrombocytopenia in a twin pregnancy.

Obstet Med 2018 Mar 10;11(1):35-38. Epub 2017 Jul 10.

Guys and St Thomas' NHS Foundation Trust, Guys Hospital, London, UK.

A 34-year-old woman presented at 29 weeks gestation of a twin pregnancy, with a platelet count of 1 × 10/l. She was extensively investigated and was subsequently diagnosed with severe immune thrombocytopenia. She did not respond to initial treatment with corticosteroids and intravenous immunoglobulin. Read More

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http://dx.doi.org/10.1177/1753495X17709188DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5888838PMC
March 2018
5 Reads

Maternal and fetal outcomes of primary immune thrombocytopenia during pregnancy: A retrospective study.

Obstet Med 2018 Mar 25;11(1):12-16. Epub 2017 Oct 25.

National Women's Health, Auckland City Hospital, New Zealand.

Objective: We reviewed outcomes of 52 pregnancies in 45 women with immune thrombocytopenic purpura who delivered at Auckland Hospital with an antenatal platelet count of <100 × 10/L.

Outcome Measures: Primary outcomes were maternal platelet count at delivery and treatment response. Secondary outcomes included post-partum haemorrhage (PPH). Read More

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http://dx.doi.org/10.1177/1753495X17727408DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5888842PMC
March 2018
6 Reads

Thrombopénie sévère chez un nouveau né de mère splénectomisé pour purpura thrombopénique idiopathique: Severe thrombopenia in an infant born to mother splenectomized for idiopathic thrombopenic purpura.

Pan Afr Med J 2017 14;28:143. Epub 2017 Oct 14.

Equipe de Recherche en Santé et Nutrition du Couple Mère-Enfant, Faculté de Médecine et de Pharmacie de Rabat, Université Mohamed V, Service de Médecine et Réanimation Néonatales, Centre Hospitalier Ibn Sina, Rabat, Maroc.

Neonatal thrombopenia is the most common hemostatic abnormality in newborns. It is defined as a platelet count below 150.000/mm. Read More

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http://dx.doi.org/10.11604/pamj.2017.28.143.13880DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5851671PMC
April 2018
9 Reads

The presentation and management of platelet disorders in pregnancy.

Eur J Haematol 2018 Jun 6;100(6):560-566. Epub 2018 Apr 6.

Department of Obstetrics and Gynaecology, University Hospital Waterford, Waterford, Ireland.

Thrombocytopenia, defined as a platelet count less than 150 000 per microlitre, occurs in 7%-12% of all pregnancies. Apart from anaemia, it is the most common haematological disorder in pregnancy. Despite its frequent occurrence, thrombocytopenia often leads to difficulties of diagnosis and management in pregnancy. Read More

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http://dx.doi.org/10.1111/ejh.13049DOI Listing
June 2018
11 Reads

Ocular posterior pole pathological modifications related to complicated pregnancy. A review.

Rom J Ophthalmol 2017 Apr-Jun;61(2):83-89

"Carol Davila" Dental Medicine University, Bucharest, Romania.

Ocular posterior pole modification are a pathological manifestation in complicated pregnancies, especially when pregnancy induced hypertension is present (PIH), as well as in preeclampsia (PE) or eclampsia. Nonetheless, as the pregnancy evolves, the possibility for an aggravated evolution with HELLP syndrome, disseminated intravascular coagulation, and idiopathic thrombocytopenic purpura may have an ocular manifestation that, mainly, implies a loss of visual field or acuity, that, left unattended, may constitute a permanent impairment. Pregestational conditions like pituitary adenoma or genetic pedigree for complement factor H gene (1q31. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5710026PMC
July 2018
9 Reads

Management of Retinal Diseases in Pregnant Patients.

J Ophthalmic Vis Res 2018 Jan-Mar;13(1):62-65

W.K. Kellogg Eye Center, Department of Ophthalmology and Visual Sciences, University of Michigan, Ann Arbor, Michigan.

Pregnancy leads to significant changes in the body, which potentially affect the retina. Pregnancy can induce disease, such as that seen in hypertensive retinopathy and choroidopathy. It can cause exudative retinal detachments in the HELLP syndrome (hemolysis, elevated liver enzymes and low platelets), disseminated intravascular coagulation (DIC), and thrombotic thrombocytopenic purpura (TTP), and provoke arterial and venous retinal occlusive disease. Read More

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http://dx.doi.org/10.4103/jovr.jovr_195_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5782459PMC
February 2018
11 Reads

Inherited thrombotic thrombocytopenic purpura mimicking immune thrombocytopenic purpura during pregnancy: a case report.

J Med Case Rep 2018 Jan 22;12(1):15. Epub 2018 Jan 22.

Department of Internal Medicine, Federal University of Pernambuco, Haematology, Av. Prof. Moraes Rego 1235, 50670-90, Recife, Brazil.

Background: Thrombotic thrombocytopenic purpura is a very rare hereditary blood deficiency disorder of ADAMTS13 (von Willebrand factor-cleaving protease) and a life-threatening thrombotic microangiopathy characterized by thrombocytopenia and microangiopathic hemolytic anemia. The deficiency in ADAMTS13 metalloprotease, which cleaves the von Willebrand factor, may be congenital or acquired. The congenital form is caused by inherited mutations in the ADAMTS13 gene. Read More

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https://jmedicalcasereports.biomedcentral.com/articles/10.11
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http://dx.doi.org/10.1186/s13256-017-1545-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5778757PMC
January 2018
15 Reads

Efficacy of treatment immune thrombocytopenic purpura in pregnancy with corticosteroids and intravenous immunoglobulin: a prospective follow-up of suggested practice.

Blood Coagul Fibrinolysis 2018 Mar;29(2):141-147

Department of Obstetrics and Gynecology, Karolinska Institutet, Clintec, Karolinska University Hospital, Stockholm, Sweden.

: The current study is performed to assess a routine for treatment of immune thrombocytopenic purpura in pregnancy. A prospective programme for monitoring and treatment with intravenous immunoglobulin or cortisone in pregnancies with immune thrombocytopenic purpura was suggested to all delivery units in Sweden. Treatment should be avoided if platelet counts were more than 20 × 10/l during pregnancy with no bleeding complications and with a target of 100 × 10/l at delivery. Read More

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http://Insights.ovid.com/crossref?an=00001721-900000000-9867
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http://dx.doi.org/10.1097/MBC.0000000000000683DOI Listing
March 2018
18 Reads

Thrombocytopenia in pregnancy.

Hematology Am Soc Hematol Educ Program 2017 12;2017(1):144-151

Maternal and Child Health Research Center, Department of Obstetrics and Gynecology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.

Thrombocytopenia develops in 5% to 10% of women during pregnancy or in the immediate postpartum period. A low platelet count is often an incidental feature, but it might also provide a biomarker of a coexisting systemic or gestational disorder and a potential reason for a maternal intervention or treatment that might pose harm to the fetus. This chapter reflects our approach to these issues with an emphasis on advances made over the past 5 to 10 years in understanding and managing the more common causes of thrombocytopenia in pregnancy. Read More

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http://dx.doi.org/10.1182/asheducation-2017.1.144DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6142617PMC
December 2017
13 Reads

A low birth weight infant with no malformations delivered by a primary immune thrombocytopenia patient treated with eltrombopag.

Int J Hematol 2018 Jul 29;108(1):109-111. Epub 2017 Nov 29.

Department of Hematology, Toyota Kosei Hospital, 500-1, Ibobara, Josui-cho, Toyota, 470-0396, Japan.

Primary immune thrombocytopenia (ITP) is defined by a low platelet count secondary to antibody-mediated platelet destruction or reductions in platelet production. Although eltrombopag is a thrombopoietin receptor agonist that increases platelet production in refractory or relapsed ITP, the influence on pregnancy is limited. We present the case of a pregnant 25-year-old ITP patient referred to our hospital with a history of two induced abortions. Read More

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http://dx.doi.org/10.1007/s12185-017-2383-1DOI Listing
July 2018
16 Reads

Diagnostic dilemma: Severe thrombotic microangiopathy in pregnancy.

J Intensive Care Soc 2017 Nov 28;18(4):348-351. Epub 2017 Jun 28.

Department of Critical Care, Portsmouth Hospitals NHS Trust, Portsmouth, UK.

A diagnostic dilemma occurred when thrombotic microangiopathy developed during pregnancy. The diagnostic criteria of thrombotic microangiopathy include thrombocytopenia (platelets <100) and microangiopathic haemolytic anaemia (including thrombotic thrombocytopenic purpura and haemolytic-uraemic syndrome). An urgent interdisciplinary approach is required to treat thrombotic microangiopathy in pregnancy to differentiate between thrombotic microangiopathy and HELLP syndrome (haemolysis, elevated liver enzymes, low platelets). Read More

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http://dx.doi.org/10.1177/1751143717715969DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5661797PMC
November 2017
8 Reads

Moderate to Severe Thrombocytopenia During Pregnancy: A Single Institutional Experience.

Indian J Hematol Blood Transfus 2017 Dec 21;33(4):581-585. Epub 2017 Feb 21.

Department of Obstetrics and Gynecology, Kangnam Sacred-Heart Hospital, Hallym University Medical Center, Hallym University College of Medicine, Seoul, South Korea.

Most of thrombocytopenic pregnant women present mild decrease of platelet counts and have favorable outcome. However, small portion of these cases can show moderate to severe thrombocytopenia and may increase the risk of bleeding during delivery. We investigated the prevalence, causes, and outcomes of pregnancies complicated by moderate to severe thrombocytopenia. Read More

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http://link.springer.com/10.1007/s12288-017-0784-1
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http://dx.doi.org/10.1007/s12288-017-0784-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5640537PMC
December 2017
10 Reads

Tolerability and safety of the intravenous immunoglobulin octagam 10% in patients with immune thrombocytopenia: a post-authorisation safety analysis of two non-interventional phase IV trials.

Hematology 2018 May 11;23(4):242-247. Epub 2017 Oct 11.

c Octapharma Inc. , Hoboken , NJ , USA.

Objectives: To provide detailed data on the tolerability and safety of octagam 10%, a ready-to-use intravenous immunoglobulin, in a subgroup of patients with immune thrombocytopenia (ITP) involved in an integrated analysis of post-authorisation safety surveillance (PASS) studies.

Methods: A subgroup analysis was conducted using data collected from two non-interventional studies that included patients with ITP treated with octagam 10%. Patients were observed and monitored for possible adverse drug reactions (ADRs) during or after administration of octagam 10%, with a particular focus on thromboembolic events (TEEs). Read More

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http://dx.doi.org/10.1080/10245332.2017.1385892DOI Listing
May 2018
22 Reads

Authors' reply re: Severe Primary Autoimmune Thrombocytopenia (ITP) in Pregnancy: a national cohort study.

BJOG 2018 04 22;125(5):630. Epub 2017 Sep 22.

Centre for Women and Children's Health Research, University of Liverpool, Liverpool Women's Hospital, Liverpool, UK.

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http://dx.doi.org/10.1111/1471-0528.14857DOI Listing
April 2018
4 Reads

TPO for ITP in pregnancy.

Blood 2017 08;130(9):1073-1074

WEILL CORNELL MEDICINE.

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http://dx.doi.org/10.1182/blood-2017-07-793356DOI Listing
August 2017
15 Reads

Effect of pregnancy in women with a history of primary immune thrombocytopenia considered as cured.

Eur J Intern Med 2017 Dec 26;46:e15-e16. Epub 2017 Aug 26.

Service de Médecine Interne, Institut Universitaire du Cancer de Toulouse Oncopole - CHU de Toulouse, Toulouse, France.

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http://dx.doi.org/10.1016/j.ejim.2017.08.023DOI Listing
December 2017
10 Reads

Fetal exposure to maternal human platelet antigen-1a does not induce tolerance. An analytical observational study.

PLoS One 2017 24;12(8):e0182957. Epub 2017 Aug 24.

Immunology Research Group, Department of Medical Biology, UiT The Artic University of Norway, Tromsø, Norway.

Fetal and neonatal alloimmune thrombocytopenia (FNAIT) is a disease that may cause severe bleeding complications with risk of perinatal death or lifelong disability. The main cause of FNAIT is maternal antibodies against human platelet antigen (HPA)-1a. Both fetomaternal bleeding and transplacental trafficking of fetal cells during pregnancy could be the cause of alloimmunization. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0182957PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5570354PMC
October 2017
17 Reads

Activated NK cells cause placental dysfunction and miscarriages in fetal alloimmune thrombocytopenia.

Nat Commun 2017 08 9;8(1):224. Epub 2017 Aug 9.

Toronto Platelet Immunobiology Group, Keenan Research Centre for Biomedical Science, St. Michael's Hospital, Toronto, ON, Canada, M5B 1W8.

Miscarriage and intrauterine growth restriction (IUGR) are devastating complications in fetal/neonatal alloimmune thrombocytopenia (FNAIT). We previously reported the mechanisms for bleeding diatheses, but it is unknown whether placental, decidual immune cells or other abnormalities at the maternal-fetal interface contribute to FNAIT. Here we show that maternal immune responses to fetal platelet antigens cause miscarriage and IUGR that are associated with vascular and immune pathologies in murine FNAIT models. Read More

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http://dx.doi.org/10.1038/s41467-017-00269-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5550461PMC
August 2017
35 Reads

Management of adult primary immune thrombocytopenia based on Japanese clinical guides.

Rinsho Ketsueki 2017 ;58(7):843-848

Department of Blood Transfusion, Osaka University Hospital.

Primary immune thrombocytopenia (also known as idiopathic thrombocytopenic purpura; ITP) is an autoimmune disorder characterized by isolated thrombocytopenia due to accelerated platelet destruction and impaired platelet production. The therapeutic goal of ITP is not to normalize the platelet count, but to elevate the platelet count to a safe range (above 30×10/µl) to minimize the risk of bleeding and to minimize the side effects of drugs such as corticosteroids and TPO receptor agonists (TPORAs). In 2011, TPORAs were approved for the management of refractory ITP in Japan. Read More

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http://dx.doi.org/10.11406/rinketsu.58.843DOI Listing
December 2017
8 Reads

Paving the way for improved management of severe immune thrombocytopenia purpura in pregnancy.

Authors:
A H James

BJOG 2018 04 28;125(5):613. Epub 2017 Aug 28.

Division of Maternal-Fetal Medicine, Duke University Medical Center, Durham, NC, USA.

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http://doi.wiley.com/10.1111/1471-0528.14827
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http://dx.doi.org/10.1111/1471-0528.14827DOI Listing
April 2018
13 Reads

Effectiveness of Helicobacter pylori eradication in pregnant women with idiopathic thrombocytopenic purpura.

J Obstet Gynaecol Res 2017 Jul;43(7):1212-1216

Department of Obstetrics and Gynecology, University of Toyama, Sugitani, Toyama, Japan.

Platelet counts increase after eradication of Helicobacter pylori (Hp) infection in non-pregnant patients with Hp-associated idiopathic thrombocytopenic purpura (ITP); however, improvement in pregnant patients has not yet been reported. We treated four pregnant women for Hp-positive ITP after Hp eradication. In three of four cases, platelet counts increased to levels exceeding 10 × 10 /L two weeks after eradication, and these levels were maintained until delivery. Read More

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http://dx.doi.org/10.1111/jog.13341DOI Listing
July 2017
15 Reads

[Thirty years of platelet immunology in fetal and neonatal alloimmune thrombocytopenia management, current situation].

Authors:
R Petermann

Transfus Clin Biol 2017 Sep 30;24(3):166-171. Epub 2017 Jun 30.

Département d'immunologie plaquettaire, Institut national de la transfusion sanguine (INTS), 6, rue Alexandre-Cabanel, 75015 Paris, France. Electronic address:

Fetal and neonatal allo-immune thrombocytopenia (FNAIT) is considered as a rare disease due to the incidence (1/1000-1/2000 births). The major complication of severe thrombocytopenia is bleeding and particularly intra-cranial hemorrhage and neurologic sequelae following. Serology and molecular biology developments have reconfigured the platelet immunology diagnosis. Read More

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http://dx.doi.org/10.1016/j.tracli.2017.05.010DOI Listing
September 2017
14 Reads