1,069 results match your criteria Immune Thrombocytopenia and Pregnancy


A Comprehensive Review of Thrombocytopenia With a Spotlight on Intensive Care Patients.

Cureus 2022 Aug 5;14(8):e27718. Epub 2022 Aug 5.

Hematology and Medical Oncology, University of Maryland Capital Region Health, Largo, USA.

Thrombocytopenia is a common entity seen in ICU patients and is associated with increased morbidity such as bleeding and transfusions, and mortality in ICU patients. Various mechanisms such as decreased platelet production, sequestration, destruction, consumption, and sometimes a combination of these factors contribute to thrombocytopenia. An understanding of the mechanism is essential to diagnose the cause of thrombocytopenia and to help provide appropriate management. Read More

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Immune-Mediated Neonatal Thrombocytopenia.

Neoreviews 2022 Jul;23(7):e462-e471

Division of Neonatology, Department of Pediatrics, University of California San Diego-Rady Children's Hospital, San Diego, CA.

Immune-mediated thrombocytopenia in neonates is caused by the transplacental passage of maternally derived antiplatelet antibodies. The 2 most common causes include neonatal alloimmune thrombocytopenia, which leads to significant thrombocytopenia and risk of intracranial hemorrhage, and autoimmune thrombocytopenia, which is generally less severe. No specific guidelines for prenatal management exist for either disease; however, intravenous immune globulin treatments and systemic steroids for women with at-risk pregnancies can be useful in both diseases. Read More

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New-onset Systemic Lupus Erythematosus in a Woman with Previous Lymphoma during Late Pregnancy: a case report and literature review.

Iran J Immunol 2022 Jun;19(2):10

Department of Obstetrics and Gynecology, Zhejiang Provincial People's Hospital, Hangzhou 310016, Zhejiang, China.

Background: Systemic lupus erythematosus (SLE) is most likely to occur during the first and second trimesters of pregnancy. There were few studies focused on the new-onset SLE during the late pregnancy or puerperium. SLE has been considered an important cause of thrombocytopenia. Read More

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Immune thrombocytopenia (ITP): diagnosis including secondary ITP, and selection of second line treatment

Haematologica 2022 06 16. Epub 2022 Jun 16.

Weill Cornell Medicine - Division of Hematology and Medical Oncology, 1300 York Ave. A603A, New York, New York 10065.

This article summarizes our approach to the diagnosis, secondary ITP, and choice of second line options in patients with immune thrombocytopenic (ITP). We very briefly summarize first-line treatment and then utilize a case-based approach. We will first explore persistent-chronic ITP in a younger female. Read More

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Long-term neurodevelopmental outcome in children after antenatal intravenous immune globulin treatment in fetal and neonatal alloimmune thrombocytopenia.

Am J Obstet Gynecol 2022 Jun 6. Epub 2022 Jun 6.

Division of Child and Adolescent Psychology, Department of Pediatrics, Willem-Alexander Children's Hospital, Leiden University Medical Center, Leiden, the Netherlands.

Background: Children with fetal and neonatal alloimmune thrombocytopenia face increased risk of intracranial hemorrhage potentially leading to developmental impairment. To prevent intracranial hemorrhage, pregnant women with alloantibodies against fetal platelets are often treated with intravenous immunoglobulin. Intravenous immunoglobulin seems effective in vastly reducing the risk of fetal or neonatal bleeding complications. Read More

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Steroid induced hypertriglyceridemia in pregnant waman with immune thrombocytopenia - case report.

Ann Med Surg (Lond) 2022 May 15;77:103636. Epub 2022 Apr 15.

Endocrine Unit, Internal Medicine Department, KFMMC, Dhahran, 31932, Saudi Arabia.

Background: Hypertriglyceridemia is a medical condition defined as fasting triglyceride level more than 150 mg/dl. It could be due to either familial or acquired cause as in obesity, metabolic syndrome, diabetes mellitus type 2, alcohol consumption, decrease exercise or drug affects. Drugs such as corticosteroids rarely induced hypertriglyceridemia, for that we are reporting this case. Read More

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Gaucher disease carrier with gestational thrombocytopenia and anemia: a case report.

J Med Case Rep 2022 May 13;16(1):203. Epub 2022 May 13.

Department of Obstetrics, Perinatal Center, National Hospital Organization Kyushu Medical Center, 1-8-1, Jigyohama Chuo-ku, Fukuoka, 810-8563, Japan.

Background: Gaucher disease is an autosomal recessive inborn error of metabolism that causes disorders of blood, bone, and central nervous system as well as hepatosplenomegaly. We present the case of a carrier of Gaucher disease with gestational thrombocytopenia and anemia that required blood transfusion therapy.

Case Presentation: A 24-year-old Nepalese primipara was diagnosed with idiopathic thrombocytopenia at 12 weeks of gestation. Read More

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Prednisone plus IVIg compared with prednisone or IVIg for immune thrombocytopenia in pregnancy: a national retrospective cohort study.

Ther Adv Hematol 2022 29;13:20406207221095226. Epub 2022 Apr 29.

Department of Internal Medicine, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing, P.R. China.

Background: The responses of intravenous immunoglobulin (IVIg) or corticosteroids as the initial treatment on pregnancy with ITP were unsatisfactory. This study aimed to assess the safety and effectiveness of prednisone plus IVIg prednisone or IVIg in pregnant patients with immune thrombocytopenia (ITP).

Methods: Between 1 January 2010 and 31 December 2020, 970 pregnancies diagnosed with ITP at 19 collaborative centers in China were reviewed in this observational study. Read More

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COVID-19 vaccine development: milestones, lessons and prospects.

Signal Transduct Target Ther 2022 05 3;7(1):146. Epub 2022 May 3.

College of Life Science and Technology, Beijing University of Chemical Technology, Beijing, China.

With the constantly mutating of SARS-CoV-2 and the emergence of Variants of Concern (VOC), the implementation of vaccination is critically important. Existing SARS-CoV-2 vaccines mainly include inactivated, live attenuated, viral vector, protein subunit, RNA, DNA, and virus-like particle (VLP) vaccines. Viral vector vaccines, protein subunit vaccines, and mRNA vaccines may induce additional cellular or humoral immune regulations, including Th cell responses and germinal center responses, and form relevant memory cells, greatly improving their efficiency. Read More

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Diagnosis and management of thrombocytopenia in pregnancy.

Authors:
Young Hoon Park

Blood Res 2022 Apr;57(S1):79-85

Division of Hematology-Oncology, Department of Internal Medicine, Ewha Womans University Mokdong Hospital, Seoul, Korea.

Thrombocytopenia, defined as platelet count <150×10/L, is frequently observed by physicians during pregnancy, with an incidence of approximately 10% of all pregnancies. Most of the cases of thrombocytopenia in pregnancy are due to gestational thrombocytopenia, which does not confer an increased risk of maternal bleeding. However, because other causes can be associated with life-threatening events, such as severe bleeding, that can affect to maternal and fetal outcomes, differentiating other cause of thrombocytopenia, which includes preeclampsia, HELLP (hemolysis, elevated liver enzymes, low platelets) syndrome, acute fatty liver of pregnancy, immune thrombocytopenia, hereditary thrombocytopenia, antiphospholipid syndrome, thrombotic thrombocytopenic purpura, and atypical hemolytic uremic syndrome, is important. Read More

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Thrombocytopenia in Pregnancy: Identification and Management at a Reference Center in Pakistan.

Cureus 2022 Mar 25;14(3):e23490. Epub 2022 Mar 25.

Hematology, National Institute of Blood Diseases and Bone Marrow Transplantation, Karachi, PAK.

Objective: The study aimed to evaluate the causes of thrombocytopenia in pregnancy and its management along with the outcome in the COVID-19 era.

Methods: Recruitment for this prospective, cross-sectional observational study of thrombocytopenia in pregnancy (platelet counts <100x10/L) was done from January 2017 to August 2020 at the National Institute of Blood Diseases (NIBD) after taking the patients' informed consent. Complete clinical and lab profile of patients was also collected. Read More

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Diagnostic Ideas and Management Strategies for Thrombocytopenia of Unknown Causes in Pregnancy.

Front Surg 2022 6;9:799826. Epub 2022 Apr 6.

Department of Gynecology and Obstetrics, Tianjin Medical University General Hospital, Tianjin, China.

Objective: To summarize the clinical characteristics and treatment options together with the maternal and neonatal prognoses in women with different degrees of thrombocytopenia of unknown causes during pregnancy.

Materials And Methods: One hundred twenty-nine cases meeting the inclusion and exclusion criteria were retrospectively analyzed. Patients were divided into group A (50*10/L) and group B (50*10/L to 100*10/L) according to the lowest level of platelet count during pregnancy. Read More

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Prenatal Exposure to Air Pollution and Immune Thrombocytopenia: A Nationwide Population-Based Cohort Study.

Front Pediatr 2022 18;10:837101. Epub 2022 Mar 18.

Children's Medical Center, Taichung Veterans General Hospital, Taichung City, Taiwan.

Introduction: Immune thrombocytopenia (ITP) is one of the most common hematologic disorders in children. However, its etiology is still unclear. Epidemiological studies have shown that air pollution is a plausible risk factor in stimulation of oxidative stress, induction of inflammation, and onset of autoimmune diseases. Read More

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Use of Eltrombopag for the First Trimester Pregnancy Complicated with Refractory Idiopathic Thrombocytopenic Purpura: A Case Report and Literature Review.

Cureus 2022 Feb 22;14(2):e22505. Epub 2022 Feb 22.

Obstetrics and Gynecology, Osaka City University Graduate School of Medicine, Osaka, JPN.

Severe idiopathic thrombocytopenic purpura (ITP) is thought to occur in approximately one in 10,000 pregnancies and refractoriness for conventional treatment is life-threatening. We herein describe a pregnant case of refractory ITP successfully treated with eltrombopag, orally medicated thrombopoietin receptor agonist (TPO-RA). The patient was diagnosed with ITP at the age of 22 and corticosteroid, immune globulin treatments, or splenectomy was invalid. Read More

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February 2022

Effect of Thrombopoietin Receptor Agonist on Pregnant Mice.

Pharmaceutics 2022 Feb 25;14(3). Epub 2022 Feb 25.

Department of Obstetrics and Gynecology, Osaka City University Graduate School of Medicine, 1-4-3 Asahimachi Abeno-ku Osaka, Osaka 545-8585, Japan.

Thrombopoietin receptor agonists (TPO-RAs) are an effective treatment for refractory immune thrombocytopenia (ITP). However, the use of TPO-RAs is limited for ITP in pregnant women due to concerns about fetal toxicity. In this study, we examined the effects of romiplostim, one of the TPO-RAs, on pregnant mice. Read More

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February 2022

How I manage pregnancy in women with Glanzmann thrombasthenia.

Blood 2022 04;139(17):2632-2641

Reference Center for Hemophilia and Other Rare Inherited Bleeding Disorders, Bicêtre Hospital APHP, Le Kremlin-Bicêtre, France; and.

Glanzmann thrombasthenia (GT) is a rare inherited platelet function disorder caused by a quantitative and/or qualitative defect of the αIIbβ3 integrin. Pregnancy and delivery are recognized risk periods for bleeding in women with GT. The newborn may also be affected by fetal and neonatal immune thrombocytopenia induced by the transplacental passage of maternal anti-αIIbβ3 antibodies, which can lead to severe hemorrhage and fetal loss. Read More

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COVID-19 vaccination among pregnant people in the United States: a systematic review.

Am J Obstet Gynecol MFM 2022 07 10;4(4):100616. Epub 2022 Mar 10.

Department of Clinical and Administrative Pharmacy, University of Georgia, Athens, GA.

Objective: Pregnant people are at increased risk of COVID-19-related morbidity and mortality, and vaccination presents an important strategy for preventing negative outcomes. However, pregnant people were not included in vaccine trials, and there are limited data on COVID-19 vaccines during pregnancy. The objectives of this systematic review were to identify the safety, immunogenicity, effectiveness, and acceptance of COVID-19 vaccination among pregnant people in the United States. Read More

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Pre- and postpregnancy platelet counts: evaluating accuracy of gestational thrombocytopenia and immune thrombocytopenia purpura diagnoses.

Am J Obstet Gynecol MFM 2022 05 11;4(3):100606. Epub 2022 Mar 11.

Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Thomas Jefferson University Hospital, Philadelphia, PA (Drs McLaren and Berghella). Electronic address:

Background: Given the overlapping clinical indicators and lack of diagnostic testing, misdiagnosis of immune thrombocytopenic purpura and gestational thrombocytopenia in pregnancy may be common. Current recommendations suggest utilizing platelet nadir during pregnancy to guide diagnosis.

Objective: This study aimed to assess the accuracy of gestational thrombocytopenia and immune thrombocytopenic purpura diagnoses using pre- and postpregnancy platelet counts. Read More

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Infantile Immune Thrombocytopenic Purpura Secondary to Perinatal Transfer of SARS-CoV-2 Antibody.

Indian Pediatr 2022 Feb;59(2):169-170

Department of Pediatrics, Bharati Hospital and Research Centre, Pune-Satara Road, Katraj-Dhankawadi, Pune, Maharashtra.

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February 2022

Risk factors for severe neonatal thrombocytopenia in cases of maternal immune thrombocytopenia.

Acta Paediatr 2022 May 31;111(5):985-991. Epub 2022 Jan 31.

Department of Obstetrics, Lille University Hospital, Lille, France.

Aim: Maternal immune thrombocytopenia (ITP) may induce neonatal thrombocytopenia (nTP), which carries a risk of neonatal haemorrhagic complications. Some risk factors for nTP have reached consensus such as maternal splenectomy and previous severe nTP, while others such as maternal platelet count have not.

Methods: We conducted a retrospective cohort study in a university hospital, including 145 neonates of mothers with ITP. Read More

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Excessive Subchorionic Fibrinoid Deposition as a Component of Massive Perivillous Fibrin Deposition: A Case With Maternal Immune Thrombocytopenia.

Pediatr Dev Pathol 2022 Jul-Aug;25(4):466-469. Epub 2022 Jan 6.

Department of Pathology, Faculty of Medicine, 26683Chulalongkorn University, Pathumwan, Thailand.

Maternal floor infarction (MFI) and massive perivillous fibrin deposition (MPFD) are overlapping placental disorders of unknown etiology, associated with adverse obstetric outcome, and a significant risk of recurrence. We describe a 31-year-old mother with asymptomatic thrombocytopenia throughout pregnancy and a positive lupus anticoagulant. She delivered a normal female neonate at term, whose weight was small for gestational age, with a placenta weighing less than the 10 percentile. Read More

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Immune thrombocytopenia purpura flare post COVID-19 vaccine.

Ann Med Surg (Lond) 2022 Mar 6;75:103164. Epub 2021 Dec 6.

Department of Hematology and Medical Oncology, Hamad Medical Corporation, Doha, Qatar.

Introduction And Importance: Coronavirus disease 2019 (COVID-19) is a recently discovered disease that has yet to be thoroughly described. It is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a novel virus that can be transmitted easily from human to human, mainly by the respiratory route. The disease often presents with non-specific symptoms such as fever, headache, and fatigue, accompanied by respiratory symptoms (e. Read More

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Pancytopenia in a newborn due to maternal piperacillin and human leukocyte antigen antibodies.

Transfus Apher Sci 2022 Apr 23;61(2):103324. Epub 2021 Nov 23.

Department of Blood Transfusion, the Affiliated Hospital of Qingdao University, Qingdao, Shandong, China. Electronic address:

Background: Piperacillin antibody-induced immune hemolytic anemia is not rare in adults, and there have been reports of anti-HLA antibody-induced newborn platelet transfusion refractoriness. However, there has been no report of piperacillin-accompanied anti-HLA antibody-induced newborn pancytopenia.

Case Report: We herein present the case of a newborn with pancytopenia from a mother who carried anti-HLA-B55, anti-HLA-DR11, and piperacillin antibodies. Read More

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Atypical hemolytic uremic syndrome: when pregnancy leads to lifelong dialysis: a case report and literature review.

Cardiovasc Endocrinol Metab 2021 Dec 17;10(4):225-230. Epub 2021 Mar 17.

Department of Internal Medicine, Division of Nephrology.

Atypical hemolytic uremic syndrome (aHUS), a challenging disorder, commonly caused by inherited defects or regulatory processes of the complement alternative pathway. There are multiple causes, including pregnancy. Pregnancy provokes life-threatening episodes, preeclampsia, hemolysis elevated liver enzymes low platelets, microangiopathic hemolytic anemia (MAHA) and end-stage renal disease. Read More

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December 2021

Moderate to Severe Thrombocytopenia in Four Pregnant Women With Asymptomatic COVID-19 Infection.

Cureus 2021 Oct 6;13(10):e18531. Epub 2021 Oct 6.

Anesthesiology, Tata Main Hospital, Jamshedpur, IND.

Coronavirus disease 2019 (COVID-19) pandemic is one of the biggest healthcare crises faced globally. Since its emergence, uncertainty about its progress and treatment options has challenged clinicians around the world. Pregnant women infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection pose a higher challenge due to the concerns of an already altered immune system during pregnancy and the disease's effect on the fetus. Read More

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October 2021

Management of refractory immune thrombocytopaenia in pregnancy.

Authors:
Jessica M Heenan

BMJ Case Rep 2021 Oct 28;14(10). Epub 2021 Oct 28.

Haematology, Launceston General Hospital, Launceston, Tasmania, Australia

A 25-year-old woman with a history of immune thrombocytopaenia (ITP) in childhood was referred to haematology clinic for review with a platelet count of 50 μ/L at 9 weeks gestation, gravida 2, para 0. She developed progressive severe thrombocytopaenia as the pregnancy progressed, with associated bleeding complications. The thrombocytopaenia was refractory to standard therapies. Read More

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October 2021

Thrombocytopenia in pregnant women.

Ginekol Pol 2021 ;92(8):587-590

Public Teaching Hospital No 4, II Department of Gynecology, Lublin, Poland.

Thrombocytopenia is one of the two most common hematological problems in pregnant women. It is defined as the platelet (PLT) count below 150 × 103/μL. Gestational incidental thrombocytopenia (GIT) represents about 75% of thrombocytopenia cases in pregnancy and it is believed that GIT is secondary to accelerated platelet destruction and increased plasma volume associated with pregnancy. Read More

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Eltrombopag treatment for severe immune thrombocytopenia during pregnancy: a case report.

Blood Coagul Fibrinolysis 2021 Oct;32(7):519-521

Hematology Unit AO of Cosenza, Cosenza.

Primary immune thrombocytopenia (ITP) is an autoimmune disorder characterized by isolated thrombocytopenia (platelet count <100 × 109/l) in the absence of other causes or disorders associated. The incidence of ITP in pregnancy is one to two cases per 1000 gestations. ITP could be diagnosed before or during pregnancy; sometimes a relapse of a previously diagnosed ITP can occur. Read More

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October 2021