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Eur J Radiol 2021 Jun 14;139:109722. Epub 2021 Apr 14.

Northwick Park, London North West University Healthcare NHS Trust, Watford Road, Harrow, HA13UJ, United Kingdom. Electronic address:

Pulsatile tinnitus (PT) can be a mild or debilitating symptom. Following clinical examination and otoscopy, when the underlying aetiology is not apparent, radiological imaging can be used to evaluate further. CT arteriography-venography (CT A-V) of the head and neck has recently been introduced as a single 'one catch' modality for identifying the many causes of PT including those which are treatable and potentially serious whilst also providing reassurance through negative studies or studies with benign findings. Read More

J Neurol Surg B Skull Base 2021 Feb 26;82(Suppl 1):S59-S60. Epub 2020 Nov 26.

Department of Otolaryngology-Head and Neck Surgery, Rutgers New Jersey Medical School, Neurological Institute of New Jersey, Saint Barnabas Medical Center, RWJ Barnabas Health, Newark, New Jersey, United States.

Glomus vagale tumor is a paraganglioma of the vagus nerve. It is a rare type of benign tumor that occupies the head and neck and skull base regions. Patients often present with lower cranial nerve dysfunctions such as difficulty swallowing, tongue weakness, and hoarseness. Read More

J Ultrason 2020 Nov 28;20(82):e218-e221. Epub 2020 Sep 28.

Faculty of Dentistry, Department of Dentomaxillofacial Radiology, Ankara, Turkey.

Glomus tumors or paragangliomas are rare benign neoplasms which are very uncommon in the head and neck region. They grow slowly from paraganglion cells, which serve various regulatory tasks in the body and form the basis of the extra-adrenal neuroendocrine system. They have benign properties, but tend to cause local invasion and expansion to adjacent anatomic structures. Read More

Head Neck 2021 02 13;43(2):449-455. Epub 2020 Oct 13.

Department of Radiation Oncology, UPMC Hillman Cancer Center, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.

Background: Data supporting linear accelerator (linac) stereotactic radiosurgery (SRS) for jugulotympanic paragangliomas (JTPs) come from small series with minimal follow-up. Herein, we report a large series of JTPs with extended follow-up after frameless linac-based SRS.

Methods: JTPs treated with linac-based SRS from 2002 to 2019 with 1+ follow-up image were reviewed for treatment failure (radiographic or clinical progression, or persistent symptoms after SRS requiring intervention) and late toxicities (CTCAE v5. Read More

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2020 May;34(5):432-435

College of Otolaryngology Head and Neck Surgery，Chinese PLA General Hospital.

To analyze the causes of misdiagnosis of patients with glomus jugulare tumor. The clinical data of 116 patients with glomus jugulare tumor were retrospectively analyzed. Among the 116 patients, 65 were misdiagnosed, the average duration of misdiagnosis was 4. Read More

Adv Otorhinolaryngol 2020 30;84:210-217. Epub 2020 Jul 30.

Department of Head and Neck Surgical Oncology, Tata Memorial Centre, Dr. Ernest Borges Marg, Mumbai, India,

Sinonasal tumours are rare, and among these there exist a small number of histologic subtypes that are infrequently encountered and rarely mentioned in the literature. These have been presented as either case reports or small case series, and their very low incidence makes prospective studies practically impossible. This review analyses the available literature, including our own experience and endeavours to outline management strategies, which involve a high index of suspicion and counselling of patients. Read More

Otolaryngol Head Neck Surg 2021 02 14;164(2):391-398. Epub 2020 Jul 14.

Department of Otolaryngology-Head and Neck Surgery, Vanderbilt University Medical Center, Nashville, Tennessee, USA.

Objectives: Management of jugular paragangliomas (PGL) has evolved toward subtotal resection (STR). The purpose of this study is to analyze neural preservation and adjuvant treatment for long-term local control.

Study Design: Retrospective chart review. Read More

Ann Otol Rhinol Laryngol 2020 Nov 2;129(11):1135-1143. Epub 2020 Jun 2.

Department of Otolaryngology, University of Colorado School of Medicine, Aurora, CO, USA.

Background: Recommendations regarding head and neck paragangliomas (HNPGL) have undergone a fundamental reorientation in the last decade as a result of increased understanding of the genetic and pathophysiologic basis of these disorders.

Objective: We aim to provide an overview of HNPGL and recent discoveries regarding their molecular genetics, along with updated recommendations on workup, treatment, and surveillance, and their implications for otolaryngologists treating patients with these disorders.

Results: susceptibility gene mutations, encoding subunits of the enzyme succinate dehydrogenase (SDH), give rise to the Hereditary Pheochromocytoma/Paraganglioma Syndromes. Read More

Head Neck 2020 09 12;42(9):2421-2430. Epub 2020 May 12.

Department of Otorhinolaryngology and Head and Neck Surgery, Campus Grosshadern, Ludwig-Maximilians-University Munich, Munich, Germany.

Background: Limited data are available on the efficacy and impact on the quality of life (Qol) of single-session image-guided robotic radiosurgery (RRS) for glomus jugulare tumors (GJTs). This study investigates the role of RRS in the management of GJTs and reviews the RRS literature.

Methods: We analyzed 53 GJT patients treated with RRS to evaluate the safety, local control, clinical outcome, and Qol assessed by the SF12v2. Read More

Neurosurg Rev 2021 Apr 21;44(2):741-752. Epub 2020 Apr 21.

Department of Neurosurgery, Stanford University School of Medicine, 300 Pasteur Drive, Edwards Bldg, Stanford, CA, USA.

Head and neck paragangliomas (HNPs) are rare, usually benign hyper vascularized neuroendocrine tumors that traditionally have been treated by surgery, with or without endovascular embolization, or, more recently stereotactic radiosurgery (SRS). The aim of our study is to determine the clinical and radiographic effectiveness of SRS for treatment of HNPs. A systematic search of electronic databases was performed, and 37 articles reporting 11,174 patients (1144 tumors) with glomus jugulare (GJT: 993, 86. Read More

J Otol 2020 Mar 14;15(1):33-35. Epub 2019 Sep 14.

Department of Medical Radiology, The Second Hospital of Hebei Medical University, Shijiazhuang, China.

Background: Tympanomastoid paragangliomas are usually benign, slowly growing, painless tumors. The common presenting symptoms of this tumor are pulsatile tinnitus and conductive hearing loss. Vertigo as the cardinal or initial symptom is extremely are, especially in the early stages of the disease. Read More

Otolaryngol Head Neck Surg 2020 Apr 25;162(4):458-468. Epub 2020 Feb 25.

Department of Otolaryngology-Head and Neck Surgery, Loyola University Medical Center, Maywood, Illinois, USA.

Objectives: To perform an evidence-based review evaluating presenting symptoms, imaging, and management for primary paragangliomas of the facial canal (PPFCs).

Data Sources: PubMed/MEDLINE, Embase, Cochrane Library, and Web of Science.

Review Methods: Studies were assessed for quality of evidence and bias with the Cochrane bias tool, GRADE, and MINORS criteria. Read More

World J Otorhinolaryngol Head Neck Surg 2019 Dec 13;5(4):175-179. Epub 2019 Dec 13.

Department of Otorhinolaryngology Head and Neck Surgery, Hospital of the University of Pennsylvania, Philadelphia, PA, USA.

Objective: To review current literature and experience with glomangiomas, or true glomus tumors of the middle ear and mastoid as well asto report on the exceptionally rare case of a glomangiomastemming from the middle ear space with multiple recurrences.

Methods: Review of existing world literature and description of personal experience with rare cases of a glomangioma of the middle ear and mastoid.

Results: Review of existing literature revealed two cases of patients presenting with tinnitus and hearing loss refractory to medical management. Read More

Otolaryngol Head Neck Surg 2020 Apr 18;162(4):504-511. Epub 2020 Feb 18.

Head & Neck Institute, Cleveland Clinic, Cleveland, Ohio, USA.

Objective: To characterize the recurrence of head and neck paragangliomas and the factors associated with disease progression after treatment.

Study Design: Retrospective cohort study.

Setting: Tertiary care center. Read More

Otol Neurotol 2020 03;41(3):e404-e411

Department of Otolaryngology-Head and Neck Surgery, Stanford University School of Medicine, Stanford, California.

Objective: To introduce the concept of ambient pressure tympanometry (APT) and its association with pathologies that may present with objective tinnitus.

Study Design: Retrospective case series.

Setting: Tertiary referral center. Read More

World Neurosurg 2019 Dec 30;132:292-294. Epub 2019 Aug 30.

Department of Neurological Surgery, University of Illinois at Chicago, Chicago, Illinois, USA; Department of Surgery, Section of Neurosurgery, Advocate Illinois Masonic Medical Center, Chicago, Illinois, USA.

Background: Endovascular embolization is an important tool in the management of multiple pathologies as a preoperative adjunct in the care of arteriovenous malformations or vascular tumors.

Case Description: We report a case of delayed distal Onyx migration after surgical resection of a glomus vagale tumor, which had been preoperatively embolized. In this report, the patient underwent successful embolectomy of the migrated Onyx fragment using manual aspiration. Read More

Otol Neurotol 2019 10;40(9):1230-1236

Department of Otolaryngology-Head and Neck Surgery.

Objective: The etiology of sensorineural hearing loss (SNHL) in patients with jugular paraganglioma (JP) whose tumors lack inner ear fistulae or vestibulocochlear nerve involvement is unknown. Recent literature has proposed that occlusion of the inferior cochlear vein may be causative. Herein, we assess the association between radiologic involvement of the cochlear aqueduct (CA) and the development of SNHL. Read More

Acta Otolaryngol 2019 Oct 27;139(10):930-933. Epub 2019 Aug 27.

Department of Otorhinolaryngology, University of Health Sciences Dışkapı Yıldırım Beyazıt Training and Research Hospital , Ankara , Turkey.

Head and neck paragangliomas are slowly growing benign tumors and they originate from specialized neural crest cells. This study aimed to express the safety of paraganglioma surgery regarding complications, treatment, and outcomes of patients with head and neck glomus tumors. Medical records of patients who were operated because of head and neck paraganglioma between 2006 and 2016 were reviewed. Read More

Iran J Otorhinolaryngol 2019 Jul;31(105):235-238

Department of Otolaryngology - Head and Neck Surgery and Audiology, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark.

Introduction: Presence of vestibular schwannoma and a simultaneous glomus jugulare tumor is an extremely rare event. There is only one case report regarding the incidence of a contralateral vestibular schwannoma, along with a glomus jugulare tumor. Herein, we present the second case with a contralateral tumor. Read More

Head Neck 2019 09 25;41(9):3356-3361. Epub 2019 Jun 25.

Cleveland Clinic, Head & Neck Institute, Cleveland, Ohio.

Background: There are conflicting recommendations and possibly overuse of imaging for surveillance of second primary tumors for patients with a history of head and neck paraganglioma.

Methods: Retrospective cohort study of 234 adults with head and neck paragangliomas (1990-2010) followed for a mean of 7.5 ± 8. Read More

Insights Imaging 2019 Mar 4;10(1):29. Epub 2019 Mar 4.

University of Rochester Medical Center, Rochester, USA.

Paragangliomas arise from paraganglion cells which serve varied regulatory tasks in the body. When these cells demonstrate neoplasia within the head and neck, they typically present in characteristic locations including the carotid space, the jugular foramen, the middle ear, and along the course of the vagus nerve. The goal of this article is to review the relevant anatomy related to head and neck paragangliomas, as well as their typical imaging characteristics on cross-sectional imaging including CT, MR, ultrasound, and nuclear medicine studies. Read More

Head Neck 2018 12 20;40(12):2677-2684. Epub 2018 Nov 20.

Department of Neurosurgery and Gamma Knife Radiosurgery, I.R.C.C.S. San Raffaele Scientific Institute, Vita-Salute University, Milan, Italy.

Background: Glomus tumors are rare and benign hypervascular tumors. Surgery represented the mainstay of their treatment, even if it has been associated with high morbidity and mortality rates. Recently, the treatment shifted to a multimodal approach and Gamma Knife radiosurgery represents one of the treatment options. Read More

Interv Neuroradiol 2019 Apr 4;25(2):230-233. Epub 2018 Nov 4.

1 Neuroradiology Department, University Hospital of Verona, Verona, Italy.

The technique of direct intratumoral injection of permanent liquid agents has evolved significantly over the past few decades. The percutaneous direct puncture technique is being utilised more and more for embolisation of head and neck hypervascular lesions. We describe a case treated via the direct percutaneous transnasal (TN) puncture technique for embolisation of a sinonasal hypervascular tumour, performed in a 21-year-old male patient. Read More

Laryngoscope 2019 01 8;129(1):67-75. Epub 2018 Sep 8.

Department of Otolaryngology-Head and Neck Surgery, University of Texas Southwestern Medical Center, Dallas, Texas, U.S.A.

Objectives/hypothesis: Pathologic involvement of the inferior cochlear vein is a mechanism of sensorineural hearing loss in patients with jugular foramen paraganglioma.

Study Design: Retrospective case-control study.

Methods: The presenting audiograms, magnetic resonance imaging, and computed tomography were reviewed in 46 subjects with jugular foramen paragangliomas. Read More

Orv Hetil 2018 Sep;159(36):1487-1492

Fül-Orr-Gégészeti és Fej-Nyaksebészeti Osztály, Borsod-Abaúj-Zemplén Megyei Központi Kórház és Egyetemi Oktatókórház Miskolc, Szentpéteri kapu 72-76., 3526.

Our goal was to report a 44-year-old woman with carotid body tumor, and to give a brief and comprehensive presentation about the disease and summarize its complex management. Carotid body tumor is a rare, mostly sporadic, benign head and neck mass originating from the glomus caroticum. It occurs mostly in middle-aged women as a slowly growing, semifix, painless neck mass. Read More

Otol Neurotol 2018 10;39(9):1079-1087

West Virginia University Department of Otolaryngology - Head and Neck Surgery, Morgantown, West Virginia.

Objective: 1) Determine tumor control, symptomatic control, and complication rates of primary radiosurgery (PRS) for treatment of glomus jugulare tumors (GJTs) via systematic review and meta-analysis. 2) Identify risk factors for these outcomes.

Data Sources: 1) Search of English articles in PubMed, Web of Science, Cochrane, and EBSCOhost databases from January 1950 to August 2017. Read More

BMJ Case Rep 2018 Jul 3;2018. Epub 2018 Jul 3.

Oral and Maxillofacial Surgery, Royal United Hospital Bath NHS Trust, Bath, UK.

The glomus tumour is a rare neoplasm derived from the glomus apparatus. Subungual sites are most common with only three published cases involving the dorsal tongue. To our knowledge, this is the first case of an intraoral malignant glomus tumour (glomangiosarcoma) to be published in English literature. Read More

Laryngoscope Investig Otolaryngol 2017 12 11;2(6):380-389. Epub 2017 Nov 11.

Department of Otolaryngology-Head and Neck Surgery Kresge Hearing Research Institute Ann Arbor Michigan U.S.A.

Objectives: Paragangliomas of the head and neck and cranial base are typically benign, slow-growing tumors arising within the jugular foramen, middle ear, carotid bifurcation, or vagus nerve proper. The objective of this study was to provide a comprehensive characterization of our institutional experience with clinical management of these tumors and posit an algorithm for diagnostic evaluation and treatment.

Methods: This was a retrospective cohort study of patients undergoing treatment for paragangliomas of the head and neck and cranial base at our institution from 2000-2017. Read More