Search Our Scientific Publications & Authors

Cureus 2022 Apr 18;14(4):e24262. Epub 2022 Apr 18.

Department of Radiology, Basildon and Thurrock University Hospital, Basildon, GBR.

Carotid body tumours (CBT), also called carotid paragangliomas, are highly vascular glomus tumours that originate from paraganglionic cells of the carotid body. They are frequently asymptomatic, insidious, and non-secretory in nature. They typically present as a large, non-tender, pulsatile neck mass. Read More

Clin Nucl Med 2022 May;47(5):e406-e407

From the Department of Nuclear Medicine, Marmara University Pendik Training and Research Hospital, Istanbul, Turkey.

Abstract: Glomus tumors are rare, slow-growing extra-adrenal paragangliomas of the head and neck. Treatment and prevention of neurological deficits become more difficult as these tumors aggressively grow in size and infiltrate adjacent anatomical structures. Because glomus tumors are paragangliomas of neuroendocrine origin, 68Ga-DOTATATE PET/CT can be used as imaging method in the diagnosis and follow-up. Read More

Indian J Radiol Imaging 2021 Jul 6;31(3):693-696. Epub 2021 Oct 6.

Department of Radio-Diagnosis, Jaslok Hospital and Research Centre, Mumbai, Maharashtra, India.

Gallbladder paraganglioma is a very rare condition, and only a few cases have been reported in the literature. Herein, we present and discuss the clinical and radiological findings of a 72-year-old woman who complained of heaviness, pain, and on and off watery discharge from the left ear for 1 year and reduced hearing in both ears. She was thoroughly investigated radiologically where multiple paragangliomas were found with the discovery of the very rare gallbladder paraganglioma. Read More

Otol Neurotol 2022 02;43(2):e279-e281

Department of Otolaryngology - Head and Neck Surgery, Hospital of the University of Pennsylvania.

We present an unusual case of chordoma arising entirely from the lateral skull base with imaging features suggestive of a paraganglioma. Clinical history, management, histopathology, and imaging characteristics are described, including a review of gallium-dotate PET scanning somatostatinreceptor-positive tumors. We further provide a review of management options, including a summary of our approach with surgical biopsy via retrosigmoid and resection via transtemporal approaches. Read More

Childs Nerv Syst 2022 02 26;38(2):269-277. Epub 2021 Oct 26.

Division of Neurosurgery, Department of Surgery and Anatomy, University Hospital, Ribeirão Preto Medical School, University of São Paulo, Ribeirao Preto, 14049-900, Brazil.

Purpose: The jugular and tympanic glomus are rare neoplasms in the general population, being even more uncommon in the pediatric population. There is considerable morbidity associated with both disease and treatment. Treatment is essentially surgical, carried out in recent years in a multidisciplinary manner using preoperative embolization associated with microsurgery and eventually adjuvant radiotherapy. Read More

Cancers (Basel) 2021 Oct 11;13(20). Epub 2021 Oct 11.

Department of Otorhinolaryngology, Head and Neck Surgery, Medical University of Vienna, 1090 Vienna, Austria.

Introduction: Temporal bone paragangliomas are rare tumors with high vascularization and usually benign entity. A variety of modalities, including gross total resection, subtotal resection, conventional or stereotactic radiotherapy including gamma-knife, embolization, and wait-and-scan strategy can be considered. The aim of this study was to compare long-term outcomes of different primary treatment modalities in temporal bone paragangliomas. Read More

World Neurosurg 2021 11 20;155:e382-e390. Epub 2021 Aug 20.

Department of Neurosurgery, Japanese Red Cross Medical Center, Tokyo, Japan.

Objective: To assess long-term outcomes of hypofractionated stereotactic radiotherapy (hSRT) for head and neck paragangliomas (HNPGs).

Methods: Patients who underwent hSRT with CyberKnife for HNPGs from 2010 to 2019 were retrospectively reviewed.

Results: A total of 34 HNPGs in 29 patients were identified. Read More

Clin Imaging 2021 Nov 8;79:314-318. Epub 2021 Aug 8.

Weill Cornell Medicine, Department of Radiology, 525 E. 68(th) St., New York, NY 10021, USA. Electronic address:

Most head and neck paragangliomas (PGLs) are biochemically silent and often present with recurrence and metastases in association with hereditary syndromes. Whole-body functional imaging is increasingly used to detect tumor extent and guide treatment planning of PGLs. [68Ga]-DOTATATE, which targets somatostatin receptor 2 (SSTR2) overexpression, has emerged as a sensitive functional imaging modality in PGLs. Read More

Oper Neurosurg (Hagerstown) 2021 10;21(5):E427-E428

Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.

Paragangliomas (PGLs) are benign hypervascular tumors that can develop in head and neck at different locations, primarily in the carotid bifurcation, jugular bulb, tympanic plexus, and vagal ganglia.1 Different gene mutations have been linked to the familial inherited forms, which can represent approximately 30% of all PGLs.1,2 These are classified into 5 different clinical syndromes: PGL 1 to 5. Read More

Ann Otol Rhinol Laryngol 2022 May 1;131(5):555-561. Epub 2021 Jul 1.

Department of Otolaryngology-Head and Neck Surgery, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ, USA.

Introduction: The presence of an aberrant internal carotid artery (ICA) in the middle ear is rare. Patients may be asymptomatic or complain of conductive hearing loss, otalgia, pulsatile tinnitus, or aural fullness. Otoscopic exam findings can include a pulsating erythematous lesion on the tympanic membrane (TM). Read More

Otol Neurotol 2021 10;42(9):e1339-e1345

Department of Radiology, Vanderbilt University Medical Center, Nashville, Tennessee.

Background: As gross total resection of jugular paragangliomas (JPs) may result in cranial nerve deficits, JPs are increasingly managed with subtotal resection (STR) with postoperative radiological monitoring. However, the validity of commonly used diameter-based models that calculate postoperative volume to determine residual tumor growth is dubious. The purpose of this study was to assess the accuracy of these models compared to manual volumetric slice-by-slice segmentation. Read More

HNO 2021 Aug 7;69(Suppl 2):88-91. Epub 2021 Jun 7.

Department of Otolaryngology, Department of Otorhinolaryngology, Head and Neck Surgery, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Waldstraße 1, 91054, Erlangen, Germany.

A 64-year-old female patient presented with otalgia and hearing loss in the right ear. On otoscopy, the right tympanic membrane was highly vascularized and bulged into the anteroinferior quadrant. High-resolution computed tomography revealed an osteolytic lesion with occupation of the hypotympanum extending into the petrous apex and right parapharyngeal space as well as infiltration of the wall of the right internal carotid artery. Read More

Interv Neuroradiol 2022 Apr 26;28(2):145-151. Epub 2021 May 26.

Department of Otolaryngology-Head and Neck Surgery, Mayo Clinic, Rochester, Minnesota, United States.

Background: Jugular paragangliomas represent a surgical challenge due to their vascularity and proximity to vital neurovascular structures. Preoperative embolization aids in reducing intraoperative blood loss, transfusion requirements, and improves surgical visualization. Several embolization agents have been used. Read More

Eur J Radiol 2021 Jun 14;139:109722. Epub 2021 Apr 14.

Northwick Park, London North West University Healthcare NHS Trust, Watford Road, Harrow, HA13UJ, United Kingdom. Electronic address:

Pulsatile tinnitus (PT) can be a mild or debilitating symptom. Following clinical examination and otoscopy, when the underlying aetiology is not apparent, radiological imaging can be used to evaluate further. CT arteriography-venography (CT A-V) of the head and neck has recently been introduced as a single 'one catch' modality for identifying the many causes of PT including those which are treatable and potentially serious whilst also providing reassurance through negative studies or studies with benign findings. Read More

J Neurol Surg B Skull Base 2021 Feb 26;82(Suppl 1):S59-S60. Epub 2020 Nov 26.

Department of Otolaryngology-Head and Neck Surgery, Rutgers New Jersey Medical School, Neurological Institute of New Jersey, Saint Barnabas Medical Center, RWJ Barnabas Health, Newark, New Jersey, United States.

Glomus vagale tumor is a paraganglioma of the vagus nerve. It is a rare type of benign tumor that occupies the head and neck and skull base regions. Patients often present with lower cranial nerve dysfunctions such as difficulty swallowing, tongue weakness, and hoarseness. Read More

J Ultrason 2020 Nov 28;20(82):e218-e221. Epub 2020 Sep 28.

Faculty of Dentistry, Department of Dentomaxillofacial Radiology, Ankara, Turkey.

Glomus tumors or paragangliomas are rare benign neoplasms which are very uncommon in the head and neck region. They grow slowly from paraganglion cells, which serve various regulatory tasks in the body and form the basis of the extra-adrenal neuroendocrine system. They have benign properties, but tend to cause local invasion and expansion to adjacent anatomic structures. Read More

Head Neck 2021 02 13;43(2):449-455. Epub 2020 Oct 13.

Department of Radiation Oncology, UPMC Hillman Cancer Center, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.

Background: Data supporting linear accelerator (linac) stereotactic radiosurgery (SRS) for jugulotympanic paragangliomas (JTPs) come from small series with minimal follow-up. Herein, we report a large series of JTPs with extended follow-up after frameless linac-based SRS.

Methods: JTPs treated with linac-based SRS from 2002 to 2019 with 1+ follow-up image were reviewed for treatment failure (radiographic or clinical progression, or persistent symptoms after SRS requiring intervention) and late toxicities (CTCAE v5. Read More

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2020 May;34(5):432-435

College of Otolaryngology Head and Neck Surgery，Chinese PLA General Hospital.

To analyze the causes of misdiagnosis of patients with glomus jugulare tumor. The clinical data of 116 patients with glomus jugulare tumor were retrospectively analyzed. Among the 116 patients, 65 were misdiagnosed, the average duration of misdiagnosis was 4. Read More

Adv Otorhinolaryngol 2020 30;84:210-217. Epub 2020 Jul 30.

Department of Head and Neck Surgical Oncology, Tata Memorial Centre, Dr. Ernest Borges Marg, Mumbai, India,

Sinonasal tumours are rare, and among these there exist a small number of histologic subtypes that are infrequently encountered and rarely mentioned in the literature. These have been presented as either case reports or small case series, and their very low incidence makes prospective studies practically impossible. This review analyses the available literature, including our own experience and endeavours to outline management strategies, which involve a high index of suspicion and counselling of patients. Read More

Otolaryngol Head Neck Surg 2021 02 14;164(2):391-398. Epub 2020 Jul 14.

Department of Otolaryngology-Head and Neck Surgery, Vanderbilt University Medical Center, Nashville, Tennessee, USA.

Objectives: Management of jugular paragangliomas (PGL) has evolved toward subtotal resection (STR). The purpose of this study is to analyze neural preservation and adjuvant treatment for long-term local control.

Study Design: Retrospective chart review. Read More

Ann Otol Rhinol Laryngol 2020 Nov 2;129(11):1135-1143. Epub 2020 Jun 2.

Department of Otolaryngology, University of Colorado School of Medicine, Aurora, CO, USA.

Background: Recommendations regarding head and neck paragangliomas (HNPGL) have undergone a fundamental reorientation in the last decade as a result of increased understanding of the genetic and pathophysiologic basis of these disorders.

Objective: We aim to provide an overview of HNPGL and recent discoveries regarding their molecular genetics, along with updated recommendations on workup, treatment, and surveillance, and their implications for otolaryngologists treating patients with these disorders.

Results: susceptibility gene mutations, encoding subunits of the enzyme succinate dehydrogenase (SDH), give rise to the Hereditary Pheochromocytoma/Paraganglioma Syndromes. Read More

Head Neck 2020 09 12;42(9):2421-2430. Epub 2020 May 12.

Department of Otorhinolaryngology and Head and Neck Surgery, Campus Grosshadern, Ludwig-Maximilians-University Munich, Munich, Germany.

Background: Limited data are available on the efficacy and impact on the quality of life (Qol) of single-session image-guided robotic radiosurgery (RRS) for glomus jugulare tumors (GJTs). This study investigates the role of RRS in the management of GJTs and reviews the RRS literature.

Methods: We analyzed 53 GJT patients treated with RRS to evaluate the safety, local control, clinical outcome, and Qol assessed by the SF12v2. Read More

Neurosurg Rev 2021 Apr 21;44(2):741-752. Epub 2020 Apr 21.

Department of Neurosurgery, Stanford University School of Medicine, 300 Pasteur Drive, Edwards Bldg, Stanford, CA, USA.

Head and neck paragangliomas (HNPs) are rare, usually benign hyper vascularized neuroendocrine tumors that traditionally have been treated by surgery, with or without endovascular embolization, or, more recently stereotactic radiosurgery (SRS). The aim of our study is to determine the clinical and radiographic effectiveness of SRS for treatment of HNPs. A systematic search of electronic databases was performed, and 37 articles reporting 11,174 patients (1144 tumors) with glomus jugulare (GJT: 993, 86. Read More

J Otol 2020 Mar 14;15(1):33-35. Epub 2019 Sep 14.

Department of Medical Radiology, The Second Hospital of Hebei Medical University, Shijiazhuang, China.

Background: Tympanomastoid paragangliomas are usually benign, slowly growing, painless tumors. The common presenting symptoms of this tumor are pulsatile tinnitus and conductive hearing loss. Vertigo as the cardinal or initial symptom is extremely are, especially in the early stages of the disease. Read More

Otolaryngol Head Neck Surg 2020 Apr 25;162(4):458-468. Epub 2020 Feb 25.

Department of Otolaryngology-Head and Neck Surgery, Loyola University Medical Center, Maywood, Illinois, USA.

Objectives: To perform an evidence-based review evaluating presenting symptoms, imaging, and management for primary paragangliomas of the facial canal (PPFCs).

Data Sources: PubMed/MEDLINE, Embase, Cochrane Library, and Web of Science.

Review Methods: Studies were assessed for quality of evidence and bias with the Cochrane bias tool, GRADE, and MINORS criteria. Read More

World J Otorhinolaryngol Head Neck Surg 2019 Dec 13;5(4):175-179. Epub 2019 Dec 13.

Department of Otorhinolaryngology Head and Neck Surgery, Hospital of the University of Pennsylvania, Philadelphia, PA, USA.

Objective: To review current literature and experience with glomangiomas, or true glomus tumors of the middle ear and mastoid as well asto report on the exceptionally rare case of a glomangiomastemming from the middle ear space with multiple recurrences.

Methods: Review of existing world literature and description of personal experience with rare cases of a glomangioma of the middle ear and mastoid.

Results: Review of existing literature revealed two cases of patients presenting with tinnitus and hearing loss refractory to medical management. Read More

Otolaryngol Head Neck Surg 2020 Apr 18;162(4):504-511. Epub 2020 Feb 18.

Head & Neck Institute, Cleveland Clinic, Cleveland, Ohio, USA.

Objective: To characterize the recurrence of head and neck paragangliomas and the factors associated with disease progression after treatment.

Study Design: Retrospective cohort study.

Setting: Tertiary care center. Read More

Otol Neurotol 2020 03;41(3):e404-e411

Department of Otolaryngology-Head and Neck Surgery, Stanford University School of Medicine, Stanford, California.

Objective: To introduce the concept of ambient pressure tympanometry (APT) and its association with pathologies that may present with objective tinnitus.

Study Design: Retrospective case series.

Setting: Tertiary referral center. Read More