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Ann Otol Rhinol Laryngol 2020 Jun 2:3489420931540. Epub 2020 Jun 2.

Department of Otolaryngology, University of Colorado School of Medicine, Aurora, CO, USA.

Background: Recommendations regarding head and neck paragangliomas (HNPGL) have undergone a fundamental reorientation in the last decade as a result of increased understanding of the genetic and pathophysiologic basis of these disorders.

Objective: We aim to provide an overview of HNPGL and recent discoveries regarding their molecular genetics, along with updated recommendations on workup, treatment, and surveillance, and their implications for otolaryngologists treating patients with these disorders.

Results: susceptibility gene mutations, encoding subunits of the enzyme succinate dehydrogenase (SDH), give rise to the Hereditary Pheochromocytoma/Paraganglioma Syndromes. Read More

J Otol 2020 Mar 14;15(1):33-35. Epub 2019 Sep 14.

Department of Medical Radiology, The Second Hospital of Hebei Medical University, Shijiazhuang, China.

Background: Tympanomastoid paragangliomas are usually benign, slowly growing, painless tumors. The common presenting symptoms of this tumor are pulsatile tinnitus and conductive hearing loss. Vertigo as the cardinal or initial symptom is extremely are, especially in the early stages of the disease. Read More

Otolaryngol Head Neck Surg 2020 Apr 25;162(4):458-468. Epub 2020 Feb 25.

Department of Otolaryngology-Head and Neck Surgery, Loyola University Medical Center, Maywood, Illinois, USA.

Objectives: To perform an evidence-based review evaluating presenting symptoms, imaging, and management for primary paragangliomas of the facial canal (PPFCs).

Data Sources: PubMed/MEDLINE, Embase, Cochrane Library, and Web of Science.

Review Methods: Studies were assessed for quality of evidence and bias with the Cochrane bias tool, GRADE, and MINORS criteria. Read More

World J Otorhinolaryngol Head Neck Surg 2019 Dec 13;5(4):175-179. Epub 2019 Dec 13.

Department of Otorhinolaryngology Head and Neck Surgery, Hospital of the University of Pennsylvania, Philadelphia, PA, USA.

Objective: To review current literature and experience with glomangiomas, or true glomus tumors of the middle ear and mastoid as well asto report on the exceptionally rare case of a glomangiomastemming from the middle ear space with multiple recurrences.

Methods: Review of existing world literature and description of personal experience with rare cases of a glomangioma of the middle ear and mastoid.

Results: Review of existing literature revealed two cases of patients presenting with tinnitus and hearing loss refractory to medical management. Read More

Otolaryngol Head Neck Surg 2020 Apr 18;162(4):504-511. Epub 2020 Feb 18.

Head & Neck Institute, Cleveland Clinic, Cleveland, Ohio, USA.

Objective: To characterize the recurrence of head and neck paragangliomas and the factors associated with disease progression after treatment.

Study Design: Retrospective cohort study.

Setting: Tertiary care center. Read More

Otol Neurotol 2020 Mar;41(3):e404-e411

Department of Otolaryngology-Head and Neck Surgery, Stanford University School of Medicine, Stanford, California.

Objective: To introduce the concept of ambient pressure tympanometry (APT) and its association with pathologies that may present with objective tinnitus.

Study Design: Retrospective case series.

Setting: Tertiary referral center. Read More

World Neurosurg 2019 Dec 30;132:292-294. Epub 2019 Aug 30.

Department of Neurological Surgery, University of Illinois at Chicago, Chicago, Illinois, USA; Department of Surgery, Section of Neurosurgery, Advocate Illinois Masonic Medical Center, Chicago, Illinois, USA.

Background: Endovascular embolization is an important tool in the management of multiple pathologies as a preoperative adjunct in the care of arteriovenous malformations or vascular tumors.

Case Description: We report a case of delayed distal Onyx migration after surgical resection of a glomus vagale tumor, which had been preoperatively embolized. In this report, the patient underwent successful embolectomy of the migrated Onyx fragment using manual aspiration. Read More

Otol Neurotol 2019 10;40(9):1230-1236

Department of Otolaryngology-Head and Neck Surgery.

Objective: The etiology of sensorineural hearing loss (SNHL) in patients with jugular paraganglioma (JP) whose tumors lack inner ear fistulae or vestibulocochlear nerve involvement is unknown. Recent literature has proposed that occlusion of the inferior cochlear vein may be causative. Herein, we assess the association between radiologic involvement of the cochlear aqueduct (CA) and the development of SNHL. Read More

Acta Otolaryngol 2019 Oct 27;139(10):930-933. Epub 2019 Aug 27.

Department of Otorhinolaryngology, University of Health Sciences Dışkapı Yıldırım Beyazıt Training and Research Hospital , Ankara , Turkey.

Head and neck paragangliomas are slowly growing benign tumors and they originate from specialized neural crest cells. This study aimed to express the safety of paraganglioma surgery regarding complications, treatment, and outcomes of patients with head and neck glomus tumors. Medical records of patients who were operated because of head and neck paraganglioma between 2006 and 2016 were reviewed. Read More

Iran J Otorhinolaryngol 2019 Jul;31(105):235-238

Department of Otolaryngology - Head and Neck Surgery and Audiology, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark.

Introduction: Presence of vestibular schwannoma and a simultaneous glomus jugulare tumor is an extremely rare event. There is only one case report regarding the incidence of a contralateral vestibular schwannoma, along with a glomus jugulare tumor. Herein, we present the second case with a contralateral tumor. Read More

Head Neck 2019 09 25;41(9):3356-3361. Epub 2019 Jun 25.

Cleveland Clinic, Head & Neck Institute, Cleveland, Ohio.

Background: There are conflicting recommendations and possibly overuse of imaging for surveillance of second primary tumors for patients with a history of head and neck paraganglioma.

Methods: Retrospective cohort study of 234 adults with head and neck paragangliomas (1990-2010) followed for a mean of 7.5 ± 8. Read More

Insights Imaging 2019 Mar 4;10(1):29. Epub 2019 Mar 4.

University of Rochester Medical Center, Rochester, USA.

Paragangliomas arise from paraganglion cells which serve varied regulatory tasks in the body. When these cells demonstrate neoplasia within the head and neck, they typically present in characteristic locations including the carotid space, the jugular foramen, the middle ear, and along the course of the vagus nerve. The goal of this article is to review the relevant anatomy related to head and neck paragangliomas, as well as their typical imaging characteristics on cross-sectional imaging including CT, MR, ultrasound, and nuclear medicine studies. Read More

Head Neck 2018 12 20;40(12):2677-2684. Epub 2018 Nov 20.

Department of Neurosurgery and Gamma Knife Radiosurgery, I.R.C.C.S. San Raffaele Scientific Institute, Vita-Salute University, Milan, Italy.

Background: Glomus tumors are rare and benign hypervascular tumors. Surgery represented the mainstay of their treatment, even if it has been associated with high morbidity and mortality rates. Recently, the treatment shifted to a multimodal approach and Gamma Knife radiosurgery represents one of the treatment options. Read More

Interv Neuroradiol 2019 Apr 4;25(2):230-233. Epub 2018 Nov 4.

1 Neuroradiology Department, University Hospital of Verona, Verona, Italy.

The technique of direct intratumoral injection of permanent liquid agents has evolved significantly over the past few decades. The percutaneous direct puncture technique is being utilised more and more for embolisation of head and neck hypervascular lesions. We describe a case treated via the direct percutaneous transnasal (TN) puncture technique for embolisation of a sinonasal hypervascular tumour, performed in a 21-year-old male patient. Read More

Laryngoscope 2019 01 8;129(1):67-75. Epub 2018 Sep 8.

Department of Otolaryngology-Head and Neck Surgery, University of Texas Southwestern Medical Center, Dallas, Texas, U.S.A.

Objectives/hypothesis: Pathologic involvement of the inferior cochlear vein is a mechanism of sensorineural hearing loss in patients with jugular foramen paraganglioma.

Study Design: Retrospective case-control study.

Methods: The presenting audiograms, magnetic resonance imaging, and computed tomography were reviewed in 46 subjects with jugular foramen paragangliomas. Read More

Orv Hetil 2018 Sep;159(36):1487-1492

Fül-Orr-Gégészeti és Fej-Nyaksebészeti Osztály, Borsod-Abaúj-Zemplén Megyei Központi Kórház és Egyetemi Oktatókórház Miskolc, Szentpéteri kapu 72-76., 3526.

Our goal was to report a 44-year-old woman with carotid body tumor, and to give a brief and comprehensive presentation about the disease and summarize its complex management. Carotid body tumor is a rare, mostly sporadic, benign head and neck mass originating from the glomus caroticum. It occurs mostly in middle-aged women as a slowly growing, semifix, painless neck mass. Read More

Otol Neurotol 2018 10;39(9):1079-1087

West Virginia University Department of Otolaryngology - Head and Neck Surgery, Morgantown, West Virginia.

Objective: 1) Determine tumor control, symptomatic control, and complication rates of primary radiosurgery (PRS) for treatment of glomus jugulare tumors (GJTs) via systematic review and meta-analysis. 2) Identify risk factors for these outcomes.

Data Sources: 1) Search of English articles in PubMed, Web of Science, Cochrane, and EBSCOhost databases from January 1950 to August 2017. Read More

BMJ Case Rep 2018 Jul 3;2018. Epub 2018 Jul 3.

Oral and Maxillofacial Surgery, Royal United Hospital Bath NHS Trust, Bath, UK.

The glomus tumour is a rare neoplasm derived from the glomus apparatus. Subungual sites are most common with only three published cases involving the dorsal tongue. To our knowledge, this is the first case of an intraoral malignant glomus tumour (glomangiosarcoma) to be published in English literature. Read More

Laryngoscope Investig Otolaryngol 2017 12 11;2(6):380-389. Epub 2017 Nov 11.

Department of Otolaryngology-Head and Neck Surgery Kresge Hearing Research Institute Ann Arbor Michigan U.S.A.

Objectives: Paragangliomas of the head and neck and cranial base are typically benign, slow-growing tumors arising within the jugular foramen, middle ear, carotid bifurcation, or vagus nerve proper. The objective of this study was to provide a comprehensive characterization of our institutional experience with clinical management of these tumors and posit an algorithm for diagnostic evaluation and treatment.

Methods: This was a retrospective cohort study of patients undergoing treatment for paragangliomas of the head and neck and cranial base at our institution from 2000-2017. Read More

J Neurosurg 2018 10 10;129(4):928-936. Epub 2017 Nov 10.

1Department of Neurological Surgery, Center for Image-guided Neurosurgery, University of Pittsburgh, Pennsylvania.

Objective: For some jugular foramen schwannomas (JFSs), complete resection is possible but may be associated with significant morbidity. Stereotactic radiosurgery (SRS) is a minimally invasive alternative or adjunct to microsurgery for JFSs. The authors reviewed clinical and imaging outcomes of SRS for patients with these tumors. Read More

Clin Nucl Med 2017 Oct;42(10):758-760

From the *Clinical Department of Nuclear Medicine, and †Clinical Department of Radiology, Clinical Hospital Centre Rijeka, Krešimirova 42, Rijeka, Croatia.

A 54-year-old woman was referred to thyroid evaluation because of a lump on the left side of the neck. Ultrasound exam did not show any thyroid abnormality, but highly perfused nodule at the left common carotid artery bifurcation was found. Because of the specific location, somatostatin receptor scintigraphy with Tc EDDA HYNIC-TOC was performed, starting with perfusion images and followed with SPECT/CT imaging at 2 and 4 hours. Read More

Pan Afr Med J 2017;26:241. Epub 2017 Apr 27.

Department of Otorhinolaryngology-Head and Neck Surgery, Military Hospital Meknes, Morocco.

Ann Otol Rhinol Laryngol 2017 Aug 1;126(8):615-618. Epub 2017 Jul 1.

3 Department of Head and Neck Surgery, Florida Hospital Celebration Health, Celebration, Florida, USA.

Objective: The entity of primary mandibular paraganglioma (PGL) is not well accepted within the head and neck. Mandibular PGLs hitherto reported in literature are malignant metastatic lesions, mostly from a pheochromocytoma.

Methods: We report a case of mandibular lytic lesion in a young female with multifocal PGLs but no family history of PGLs. Read More

Ann Otol Rhinol Laryngol 2017 Aug 10;126(8):606-610. Epub 2017 Jun 10.

1 Division of Otolaryngology-Head and Neck Surgery, Department of Surgery, University of Utah, Salt Lake City, Utah, USA.

Objectives: To describe a case of metastatic renal cell carcinoma (RCC) masquerading as a jugular foramen paraganglioma (JP). To compare imaging findings between skull base metastatic RCC and histologically proven paraganglioma.

Methods: A case of unexpected metastatic skull base RCC is reviewed. Read More

Case Rep Neurol 2017 Jan-Apr;9(1):54-61. Epub 2017 Apr 3.

Department of Medicine, Bronx Lebanon Hospital Center, Bronx, NY, USA.

Cranial nerve palsy could be one of the presenting features of underlying benign or malignant tumors of the head and neck. The tumor can involve the cranial nerves by local compression, direct infiltration or by paraneoplastic process. Cranial nerve involvement depends on the anatomical course of the cranial nerve and the site of the tumor. Read More

Asia Pac J Clin Oncol 2018 Apr 24;14(2):e3-e7. Epub 2017 May 24.

Department of Radiation Oncology, Acibadem University, Istanbul, Turkey.

Aim: CyberKnife is a robotic stereotactic radiotherapy system. The aim of this study is to evaluate the effectiveness and the safety of CyberKnife on treating head and neck paragangliomas and to report our results.

Methods: Between March 2009 and June 2014, 12 patients with head and neck paragangliomas have been referred to our clinic: in three cases had jugular paragangliomas, five cases had carotid body paragangliomas and three cases had tympanic paragangliomas. Read More

World Neurosurg 2017 Aug 9;104:14-23. Epub 2017 May 9.

Department of Neurosurgery, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

Objective: Dumbbell-shaped jugular foramen tumors (DSJFTs) extending to the neck present diagnostic and management difficulties because of their rarity, various pathologies, and multidisciplinary involvement. Accurate imaging findings are of great importance for surgical planning and clinical outcomes. However, few articles have discussed this issue to date. Read More

J Craniofac Surg 2017 May;28(3):e271-e273

*Department of Otorhinolaryngology, Head and Neck Surgery, Istanbul Medical Faculty, University of Istanbul †Department of Pathology, Istanbul Medical Faculty, University of Istanbul, Istanbul, Turkey.

Cervical metastases from breast carcinoma are extremely rare after several years of disease-free survival. In this article, a metastatic tumor of the neck originating from a breast carcinoma, which has been treated 14 years ago, is discussed. A case is presented of a 48-year-old female patient with a history of breast carcinoma, which was surgically treated approximately 14 years ago. Read More

J Ultrasound 2017 Mar 13;20(1):73-79. Epub 2017 Jan 13.

Department of Pathology, University College of Medical Sciences (University of Delhi) and GTB Hospital, Dilshad Garden, Delhi, 110095 India.

Vagal paragangliomas are rare benign tumors accounting for only 3% of head and neck paragangliomas and arise from vagal ganglions, predominately the nodose ganglion in the carotid sheath. Imaging plays an important role in their diagnosis, differentiation from more common lesions presenting in the carotid space, and management. MRI is the method of choice for investigation when paragangliomas are clinically suspected. Read More

Laryngoscope 2017 12 14;127(12):2873-2882. Epub 2017 Mar 14.

Department of Otolaryngology and Communication Enhancement, Boston Children's Hospital, Boston, Massachusetts, U.S.A.

Objectives/hypothesis: To describe our current multidisciplinary approach to pediatric malignant glomus tumors of the head and neck and review the current literature.

Study Design: Retrospective chart review at a tertiary referral children's hospital and a comprehensive literature review.

Methods: A comprehensive literature search of PubMed, Embase, Web of Science, Google Scholar, and EBSCO with respect to malignant glomus tumors of the head and neck was conducted. Read More

World Neurosurg 2017 May 27;101:559-567. Epub 2017 Feb 27.

Department of Neurosurgery, Baylor College of Medicine, Houston, Texas, USA; Department of Neurosurgery, The University of Texas M. D. Anderson Cancer Center, Houston, Texas, USA. Electronic address:

Background: Carotid body paragangliomas are rare, usually benign, tumors arising from glomus cells of the carotid body. Bilateral involvement is present in ∼5% of sporadic cases and up to one third of familial cases. In most patients undergoing bilateral resection of carotid body tumors, a condition known as baroreflex failure syndrome (BFS) develops after resection of the second tumor characterized by headache, anxiety, emotional lability, orthostatic lightheadedness, hypertension, and tachycardia. Read More

Am J Otolaryngol 2017 Jan - Feb;38(1):100-102. Epub 2016 Sep 28.

Otolaryngology-Head and Neck Surgery, Eastern Virginia Medical School, 600 Gresham Drive Suite 1100, VA, Norfolk, VA, United States.

Cholesterol granuloma (CG) is the most common benign lesion of the petrous apex, however, it can grow significantly large and become destructive causing a diagnostic dilemma. This case presents a 25-year-old female with 2-year history of left-sided progressive and profound hearing loss, a transient left-sided facial paralysis and cranial nerve 10 palsy who presented with a blue middle ear mass. Her diagnosis did not become apparent until direct visualization intraoperatively. Read More

Clin Nucl Med 2017 Feb;42(2):135-137

From the Departments of *Nuclear Medicine, †Clinical Radiology-Neuroradiology, and ‡Otorhinolaryngology, Head and Neck Surgery, University Hospital Münster, Münster, Germany.

A 60-year-old woman was referred to contrast-enhanced CT for evaluation of jugular vein thrombosis incidentally detected by ultrasound. Contrast-enhanced CT showed an enhanced tumor of the right skull base highly suspicious of jugulotympanic paraganglioma. However, the jugular veins showed a nearly symmetric contrast enhancement without clear evidence of thrombosis. Read More

Eur Arch Otorhinolaryngol 2017 Jan 5;274(1):389-397. Epub 2016 Jul 5.

Head and Neck Centre, Otorhinolaryngology, Head and Neck Surgery, University of Helsinki and Helsinki University Hospital, Haartmaninkatu 4, 00029, Helsinki, HUS, Finland.

Treatment of jugulotympanic paragangliomas (JTPGLs) remains challenging with no clear guidelines for management or follow-up. The aim of this retrospective case-note study was to assess long-term results of operatively and conservatively managed JTPGLs between years 1974-2013. A total of 36 patients with JTPGLs were identified. Read More

JAMA Otolaryngol Head Neck Surg 2017 01;143(1):87-88

Department of Otolaryngology-Head and Neck Surgery, Stanford University, Palo Alto, California.

Ann Emerg Med 2016 Jul;68(1):e9-e10

Department of Otolaryngology-Head and Neck Surgery, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan.

Am J Otolaryngol 2016 May-Jun;37(3):255-8. Epub 2016 Feb 2.

Department of Otolaryngology-Head and Neck Surgery, Vanderbilt University Medical Center, Nashville, TN. Electronic address:

Objective: To evaluate radiographic tumor control and treatment-related toxicity in glomus jugulare tumors treated with stereotactic radiosurgery (SRS).

Study Design: Retrospective chart review.

Setting: Tertiary academic referral center. Read More

Am J Clin Oncol 2018 03;41(3):223-226

Neurosurgery, University of Florida College of Medicine, Gainesville, FL.

Objectives: To determine the long-term outcome after stereotactic radiosurgery (SRS) for temporal bone paragangliomas.

Materials And Methods: We retrospectively reviewed the medical records of 11 patients with temporal bone paragangliomas (10 patients with a glomus jugulare tumor and 1 patient with a glomus tympanicum tumor) treated between January 1997 and July 2012 at the University of Florida with SRS to a median dose of 15 Gy in 1 fraction. Ten previously unirradiated patients received SRS as did 1 patient who received prior fractionated radiotherapy (FRT) and then received salvage SRS for a local recurrence. Read More

Clin Nucl Med 2016 Feb;41(2):150-2

From the Departments of *Nuclear Medicine and PET, and †ENT, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

Metastatic jugular paraganglioma are rare tumors and account for less than 1% of the cases of head and neck tumors. We report a 40-year-old woman of jugular paraganglioma, presenting with right-sided neck swelling, hearing loss, and pulsatile tinnitus. Contrast-enhanced CT temporal bone revealed a mass in the right jugular foramina and extending inferiorly to internal jugular vein. Read More

Head Neck 2016 06 28;38(6):899-905. Epub 2015 Nov 28.

Department of Otology and Skull Base Surgery, Gruppo Otologico, Piacenza-Rome, Italy.

Background: Management of the cervical and petrous internal carotid artery (ICA) is frequently required in Fisch class C tympanojugular paragangliomas (TJPs). The purpose of this study was to discuss the perioperative intervention of the ICA in patients who underwent surgical resection of a TJP.

Methods: A retrospective study of 237 patients surgically treated for Fisch class C TJPs was done to identify cases that required ICA management. Read More

Head Neck 2016 06 7;38(6):871-85. Epub 2015 Sep 7.

Department of Otology and Skull Base Surgery, Gruppo Otologico, Piacenza, Rome, Italy.

Background: The purpose of this study was to share our review of surgical strategies and long-term outcomes in the management of tympanojugular paragangliomas.

Methods: This was a retrospective study with a literature review. The records of 184 patients with 185 tympanojugular paragangliomas were analyzed for tumor class, surgical procedure, preoperative vascular management, and perioperative sequelae. Read More

J Neurol Surg B Skull Base 2015 Aug 12;76(4):249-51. Epub 2015 Mar 12.

Section of Neuroradiology, Department of Radiology, University of California Davis Medical Center, Sacramento, California, United States.

Objectives To evaluate angiographic patterns that may predict the success or failure of carotid artery balloon test occlusion (BTO) and single-photon emission computed tomography (SPECT) analysis for carotid sacrifice. Study Design This is a retrospective nonrandomized study. Study Setting Conducted at the University of California Davis Medical Center, Sacramento, California. Read More

Kulak Burun Bogaz Ihtis Derg 2015 ;25(4):232-6

Department of Otolaryngology, Anadolu Medical Center, 41400 Gebze, Kocaeli, Turkey.

Paragangliomas of the head and neck are usually benign tumors. Malignant form is quite rare and criteria for malignancy are not clear. Clinical, biochemical and histological features of malignant forms are not sufficient to reliably distinguish them from benign tumors and malignancy is established only in the presence of distant metastasis. Read More

Head Neck 2016 Feb 15;38(2):267-76. Epub 2015 Jun 15.

Ear, Nose, and Throat Department, Hospital General Universitario Gregorio Marañón, Madrid, Spain.

Background: The purpose of this study was to reflect our experience in the management of multicentric head and neck paragangliomas, including genetic study and counseling, diagnostic tools, types of treatment, and the need for monitoring.

Methods: A retrospective review of 24 patients with multicentric paraganglioma, including a total of 60 paragangliomas: 37 carotid body tumors, 13 jugulotympanic paragangliomas, and 10 vagal paragangliomas.

Results: A total of 26 surgical procedures were performed, including the resection of 36 paragangliomas. Read More

Rofo 2015 Jun 27;187(6):409-14. Epub 2015 May 27.

Otolaryngol Clin North Am 2015 Jun 11;48(3):515-26. Epub 2015 Apr 11.

Department of Neurologic Surgery, Mayo Clinic School of Medicine, Mayo Clinic, 200 First Street Southwest, Rochester, MN 55905, USA; Department of Otolaryngology-Head and Neck Surgery, Mayo Clinic School of Medicine, 200 First Street Southwest, Rochester, MN 55905, USA. Electronic address:

Gamma Knife stereotactic radiosurgery (GKS) has become an important management strategy for an increasing number of patients with skull base tumors. For select patients with lateral skull base disorders, given the proximity to sensitive critical structures such as the brainstem, cranial nerves, and cochlea, this technology has emerged as a first-line treatment to achieve the paramount goals of long-term tumor control and maintenance of existing neurologic function. This article reviews the indications, technique, and results of GKS for the treatment of vestibular schwannoma and glomus jugulare tumors, and highlights our experience in treating these tumors at the Mayo Clinic. Read More

Rev Esp Med Nucl Imagen Mol 2015 Sep-Oct;34(5):321-4. Epub 2015 Apr 6.

Servicio de Medicina Nuclear, Hospital Meixoeiro, Vigo, Pontevedra, España.

Head and neck paragangliomas are rare neuroendocrine tumors expressing somatostatin receptors on their cell surface, particularly subtype 2. Due to this distinctive feature, images can be obtained in Nuclear Medicine using synthetic analogues of somatostatin, mainly octreotide, which allow selective display by planar scintigraphy, SPECT-CT or PET-CT imaging after radiolabeling with (111)In or (68)Ga. Three cases have been selected and presented from a series of patients that illustrate the utility of SPECT-CT studies with (111)In-octreotide in the diagnosis and monitoring of this type of tumor. Read More

Eur J Nucl Med Mol Imaging 2015 Jul 31;42(8):1223-30. Epub 2015 Mar 31.

THERANOSTICS Centre for Molecular Radiotherapy and Molecular Imaging, ENETS Center of Excellence, Zentralklinik Bad Berka, Robert Koch Allee, Bad Berka, 99437, Germany.

Purpose: Head and neck paragangliomas (HNPGLs) are rare tumours arising from autonomic nervous system ganglia. Although surgery offers the best chance of complete cure, there is associated morbidity due to the crucial location of these tumours. Radiotherapy arrests tumour growth and provides symptomatic improvement, but has long-term consequences. Read More