135 results match your criteria Imaging in Wegener Granulomatosis Thoracic


Eosinophilic angiocentric fibrosis : a sino-orbital masquerader.

BMJ Case Rep 2018 Aug 9;2018. Epub 2018 Aug 9.

Ophthalmology, Orlando VA Medical Center, Orlando, Florida, USA.

A 58-year-old Caucasian male presented with left periorbital oedema extending to the nasal area for 1 year along with nasal discharge for 1 month. Lab work was significant for positive cytoplasmic antineutrophil cytoplasmic antibodies. CT scan showed solid mass along the nasal soft tissue with bony nasal destruction. Read More

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http://dx.doi.org/10.1136/bcr-2017-223675DOI Listing
August 2018
4 Reads

Eosinophilic granulomatosis with polyangiitis and laryngeal involvement: review of the literature and a cross-sectional prospective experience.

J Laryngol Otol 2018 Jul 11;132(7):619-623. Epub 2018 Jun 11.

Rheumatology Unit,University of Pisa,Italy.

Background: Eosinophilic granulomatosis with polyangiitis and granulomatosis with polyangiitis show variable otorhinolaryngological involvement. Up to 14 per cent of granulomatosis with polyangiitis patients have subglottis involvement; little is known about the laryngeal involvement in eosinophilic granulomatosis with polyangiitis.

Method: A literature review was conducted, together with a prospective cross-sectional analysis of 43 eosinophilic granulomatosis with polyangiitis patients. Read More

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http://dx.doi.org/10.1017/S0022215118000737DOI Listing
July 2018
2 Reads

Comparison of findings on thoracic computed tomography with the severity and duration of bronchial asthma in patients with eosinophilic granulomatosis with polyangiitis.

Respir Med 2018 06 9;139:101-105. Epub 2018 May 9.

Department of Respiratory Medicine, Kyorin University School of Medicine, Mitaka, Tokyo, Japan. Electronic address:

Background: Eosinophilic granulomatosis with polyangiitis (EGPA) is a systemic necrotizing vasculitis with eosinophilia. EGPA can occur in patients with comorbid bronchial asthma (BA) and other pulmonary diseases. However, because of its rarity, there are few reports on thoracic computed tomography (CT) findings in patients with EGPA, especially in relation to comorbid BA. Read More

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http://dx.doi.org/10.1016/j.rmed.2018.05.003DOI Listing
June 2018
2 Reads

A rare case of mitral valve dissection and aortic-left ventricular tunnel associated with possible autoimmune vasculitis.

Echocardiography 2018 06 14;35(6):893-894. Epub 2018 May 14.

Department of Echocardiography, Fuwai Hospital, National Center for Cardiovascular Diseases, Beijing, China.

We report a very rare case of mitral valve dissection and aortic-left ventricular tunnel caused by possible autoimmune vasculitis. We suspected Behcet's disease in this patient. There was no obvious clinical evidence of infective endocarditis. Read More

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http://dx.doi.org/10.1111/echo.14007DOI Listing
June 2018
6 Reads

Cavitary Lung Diseases: A Clinical-Radiologic Algorithmic Approach.

Chest 2018 Jun 6;153(6):1443-1465. Epub 2018 Mar 6.

Pulmonary Division, Lenox Hill Hospital Northwell Health, New York, NY. Electronic address:

Cavities occasionally are encountered on thoracic images. Their differential diagnosis is large and includes, among others, various infections, autoimmune conditions, and primary and metastatic malignancies. We offer an algorithmic approach to their evaluation by initially excluding mimics of cavities and then broadly classifying them according to the duration of clinical symptoms and radiographic abnormalities. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00123692183039
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http://dx.doi.org/10.1016/j.chest.2018.02.026DOI Listing
June 2018
49 Reads

Eosinophilic granulomatosis with polyangiitis without respiratory symptoms or asthma in an adolescent: case report and literature review.

Rheumatol Int 2018 Apr 30;38(4):697-703. Epub 2017 Nov 30.

Department of Pediatric Rheumatology, Pamukkale University School of Medicine, Pamukkale, Denizli, Turkey.

Eosinophilic granulomatosis with polyangiitis (EGPA), also known as Churg-Strauss syndrome, is a systemic necrotizing vasculitis of the small and medium vessels. It is primarily associated with respiratory conditions such as asthma and sinusitis as well as eosinophilia, neuropathy, pulmonary infiltrates, and vasculitis. EGPA is extremely rare in the pediatric age group, and respiratory system disorders are usually predominant in EGPA patients. Read More

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http://dx.doi.org/10.1007/s00296-017-3884-1DOI Listing
April 2018
14 Reads

Seronegative granulomatosis with polyangiitis presenting with multiple cranial nerve palsies.

Neuropathology 2018 Apr 14;38(2):192-197. Epub 2017 Nov 14.

Department of Pathology, Seoul National University Hospital, College of Medicine, Seoul, Republic of Korea.

Granulomatosis with polyangiitis (GPA), previously known as Wegener's granulomatosis (WG), is a rare systemic disease characterized by necrotizing granulomas and vasculitis that usually presents in the respiratory tract and renal system. Here, we report a case of anti-neutrophil cytoplasmic antibody (ANCA)-negative GPA with diagnostic difficulties. Neurologic involvement in GPA is not uncommon, with up to 50% of patients manifesting with neurologic defects; however, it is usually a late event. Read More

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http://dx.doi.org/10.1111/neup.12437DOI Listing
April 2018
2 Reads

Pulmonary Involvement in Antineutrophil Cytoplasmic Antibodies (ANCA)-associated Vasculitis: The Influence of ANCA Subtype.

J Rheumatol 2017 Oct 1;44(10):1458-1467. Epub 2017 Aug 1.

From the Department of Clinical Sciences, Section of Rheumatology, Lund University, Lund, Sweden; Vasculitis and Lupus Clinic, and Department of Radiology, and Department of Respiratory Medicine, Addenbrooke's Hospital, Cambridge, UK.

Objective: To describe pulmonary involvement at time of diagnosis in antineutrophil cytoplasmic antibodies (ANCA)-associated vasculitis (AAV), as defined by computed tomography (CT).

Methods: Patients with thoracic CT performed on or after the onset of AAV (n = 140; 75 women; granulomatosis with polyangiitis, n = 79; microscopic polyangiitis MPA, n = 61) followed at a tertiary referral center vasculitis clinic were studied. Radiological patterns of pulmonary involvement were evaluated from the CT studies using a predefined protocol, and compared to proteinase 3 (PR3)-ANCA and myeloperoxidase (MPO)-ANCA specificity. Read More

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http://dx.doi.org/10.3899/jrheum.161224DOI Listing
October 2017
24 Reads

Pseudotumoral form of granulomatosis with polyangiitis.

Pan Afr Med J 2017;26:173. Epub 2017 Mar 27.

Internal Medicine Department, Mohammed V Military Teaching Hospital, Rabat, Morocco.

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http://dx.doi.org/10.11604/pamj.2017.26.173.12195DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5483351PMC
February 2018
2 Reads

Pulmonary-Limited Granulomatosis with Polyangiitis Coexisting with Mixed Connective Tissue Disease.

Tohoku J Exp Med 2017 06;242(2):109-114

Department of Respiratory Medicine and Infectious Diseases, Oita University Faculty of Medicine.

Granulomatosis with polyangiitis (GPA) is a systemic disease characterized by necrotizing, granulomatous vasculitis of the upper and lower respiratory tracts and glomerulonephritis, and is classified as a classical or limited form. The classical form of GPA demonstrates the involvement of the upper respiratory tract, sinuses, lungs and kidneys, whereas the limited form is characterized by the lack of the renal involvement with female predominance. On the other hand, mixed connective tissue disease (MCTD) shows the clinical and laboratorial features of systemic lupus erythematosus, systemic sclerosis and polymyositis, along with high titers of anti-ribonucleoprotein antibodies and is characterized by good response to corticosteroid therapy and favorable prognosis. Read More

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http://dx.doi.org/10.1620/tjem.242.109DOI Listing
June 2017
32 Reads

Bilateral acute angle-closure glaucoma as a first presentation of granulomatosis with polyangiitis (Wegener's).

Arq Bras Oftalmol 2016 Sep-Oct;79(5):336-338

Department of Ophthalmology, School of Medicine, Gaziantep University, Gaziantep, Turkey.

We report a case of bilateral acute angle-closure glaucoma in a patient with undiagnosed granulomatosis with polyangiitis (Wegener's). A 59-year-old man presented with a severe headache, ocular pain, blurred vision, shortness of breath, and mild fever. Clinical examination revealed conjunctival chemosis, corneal edema, and shallow anterior chambers. Read More

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http://dx.doi.org/10.5935/0004-2749.20160096DOI Listing
July 2017
11 Reads

Intratracheal Dilation-injection Technique in the Treatment of Granulomatosis with Polyangiitis Patients with Subglottic Stenosis.

J Rheumatol 2016 11 15;43(11):2042-2048. Epub 2016 Sep 15.

From the Third Department of Pneumonology, and Department of Thoracic Surgery, and Department of Radiology, and Department of Pathology, National Research Institute of Tuberculosis and Lung Diseases, Warsaw, Poland.

Objective: An analysis of subglottic stenosis (SGS) occurrence frequency in patients with granulomatosis with polyangiitis (GPA) based on the time of appearance of clinical symptoms, and an assessment of treatment effectiveness, in particular with the intratracheal dilation-injection technique (IDIT).

Methods: Review and treatment with IDIT of 34 patients with SGS associated with GPA.

Results: SGS developed in 34 of 250 patients with GPA (13. Read More

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http://dx.doi.org/10.3899/jrheum.151355DOI Listing
November 2016
12 Reads

Eosinophilic granulomatosis with polyangiitis and bronchogenic cyst.

Asian Cardiovasc Thorac Ann 2017 Nov 28;25(9):657-659. Epub 2016 Oct 28.

Department of Thoracic Surgery, Cerrahpasa Medical Faculty, Istanbul University, Istanbul, Turkey.

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http://dx.doi.org/10.1177/0218492316678120DOI Listing
November 2017
1 Read

Imaging of Eosinophilic Lung Diseases.

Radiol Clin North Am 2016 Nov 12;54(6):1151-1164. Epub 2016 Aug 12.

Department of Diagnostic Radiology, University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Unit 1478, Houston, TX 77030, USA. Electronic address:

Eosinophilic lung diseases encompass a broad range of conditions wherein patients present with pulmonary opacities and eosinophilia of the serum, pulmonary tissue, or bronchoalveolar lavage fluid. Many of these entities can be idiopathic or are secondary to parasitic infection, exposure to drugs, toxins, or radiation. These diseases exhibit a wide range of imaging findings, including consolidation, ground-glass opacities, nodules, and masses. Read More

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http://dx.doi.org/10.1016/j.rcl.2016.05.008DOI Listing
November 2016
6 Reads

Pulmonary Vasculitis: Spectrum of Imaging Appearances.

Radiol Clin North Am 2016 Nov 13;54(6):1097-1118. Epub 2016 Aug 13.

Section of Thoracic Imaging, Imaging Institute, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USA; Section of Cardiovascular Imaging, Imaging Institute, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USA. Electronic address:

Pulmonary vasculitis is a relatively uncommon disorder, usually manifesting as part of systemic vasculitis. Imaging, specifically computed tomography, is often performed in the initial diagnostic workup. Although the findings in vasculitis can be nonspecific, they can provide important clues in the diagnosis, and guide the clinical team toward the right diagnosis. Read More

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http://dx.doi.org/10.1016/j.rcl.2016.05.007DOI Listing
November 2016
2 Reads

Antineutrophil cytoplasmic antibody positivity in IgG4-related disease: A case report and review of the literature.

Medicine (Baltimore) 2016 Aug;95(34):e4633

aUniversità Vita-Salute San Raffaele, IRCCS-San Raffaele Scientific Institute bDivision of Immunology, Transplantation and Infectious Diseases, IRCCS-San Raffaele Scientific Institute cUnit of Medicine and Clinical Immunology, IRCCS-San Raffaele Scientific Institute dDepartment of Thoracic Surgery, IRCCS-San Raffaele Scientific Institute eLaboraf Diagnostic Research, IRCCS-San Raffaele Scientific Institute fDivision of Nuclear Medicine, IRCCS-San Raffaele Scientific Institute gDepartment of Ophthalmology, IRCCS-San Raffaele Scientific Institute, Milan, Italy hDivision of Rheumatology, Allergy, and Immunology, Massachusetts General Hospital, Harvard Medical School, Boston, MA iPathology Unit, IRCCS-San Raffaele Scientific Institute, Milan, Italy.

Background: IgG4-related disease (IgG4-RD) is a fibroinflammatory condition characterized by serum IgG4 elevation and tissue infiltration of IgG4-positive plasma cells. Substantial overlap between IgG4-RD and antineutrophil cytoplasmic antibodies (ANCA)-associated vasculitides (AAV) exists in terms of organ involvement and histopathological features. A positive ANCA assay is regarded as a highly specific finding in favor of an AAV, and generally influences away from a diagnosis of IgG4-RD. Read More

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http://dx.doi.org/10.1097/MD.0000000000004633DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5400329PMC
August 2016
26 Reads

Thoracic intradural extramedullary lesions causing progressive myelopathy as an initial manifestation of granulomatosis with polyangiitis: a case report and review of literature.

J Spinal Cord Med 2017 01 22;40(1):122-125. Epub 2016 Apr 22.

a Department of Orthopedic Surgery , The University of Tokyo Hospital , Tokyo , Japan.

Context: To our knowledge, only a few reports regarding the spinal involvement of granulomatosis with polyangiitis (GPA)-also termed as Wegener's granulomatosis-have been published. However, all these cases reportedly exhibited epidural tumor-like lesions or dural thickening.

Findings: We report the case of a 57-year-old woman with progressive myelopathy caused by multiple spinal lesions with GPA, which appeared to be protruding inwards, within the dura mater, on magnetic resonance imaging (MRI); these lesions were difficult to distinguish from intradural tumors. Read More

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http://dx.doi.org/10.1080/10790268.2016.1173319DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5376146PMC
January 2017
14 Reads

Imaging findings of pulmonary granulomatosis with polyangiitis (Wegener's granulomatosis): lesions invading the pulmonary fissure, pleura or diaphragm mimicking malignancy.

Wien Klin Wochenschr 2016 Nov 10;128(21-22):809-815. Epub 2015 Apr 10.

Department of Radiology, Ege University School of Medicine, Izmir, Turkey.

Background: Granulomatosis with polyangiitis (GPA, formerly Wegener's granulomatosis), in which pulmonary involvement often predominates, is a multisystem granulomatous, necrotizing vasculitis that affects small and medium-sized vessels. In this study we evaluated various radiological findings of pulmonary GPA and focused on spiculated pulmonary lesions invading the pulmonary fissure, pleura or diaphragm mimicking malignancy.

Methods: This retrospective study included 48 patients, aged 28-73 (mean, 47. Read More

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http://dx.doi.org/10.1007/s00508-015-0747-1DOI Listing
November 2016
12 Reads

Pulmonary fibrosis in antineutrophil cytoplasmic antibodies (ANCA)-associated vasculitis: a series of 49 patients and review of the literature.

Medicine (Baltimore) 2014 Nov;93(24):340-9

From the Departement Hospitalo-Universitaire I2B (CC, B. Hervier, PC, DS), UPMC Univ Paris 06, UMR 7211, F-75005, Paris; INSERM, UMR_S 959 (CC, PC, DS), F-75013, Paris; CNRS, UMR 7211 (CC, PC, DS), F-75005, Paris; AP-HP, Groupe Hospitalier Pitié-Salpêtrière, Department of Internal Medicine and Clinical Immunology (CC, B. Hervier, FCA, PC, DS), F-75013, Paris; AP-HP, Hôpital Bichat, Service de Pneumologie A (BC), Université Paris Diderot-Paris VII, Paris; AP-HP, Hôpital Saint-Louis, Service de Pneumologie (AT), Université Paris Diderot-Paris VII, Sorbonne Paris Cité, INSERM UMR 717, Paris; Centre Hospitalier Régional et Universitaire de Tours, Service de Pneumologie (SAM), Tours; AP-HP, Centre Hospitalier et Universitaire d'Avicenne, Service de Pneumologie (HN), Bobigny; AP-HP, Hôpital Tenon, Service de Pneumologie (MW, J. Cadranel), UPMC-Paris VI, Paris; Centre Hospitalier Intercommunal de Créteil, Service de Pneumologie (B. Housset), Créteil; AP-HP, Hôpital Lariboisière, Service de Médecine Interne A (CLL), Paris; Hospices Civils de Lyon, Hôpital de la Croix-Rousse, Service de Médecine Interne (PS), Lyon; AP-HP, Centre hospitalier et universitaire d'Avicenne, Service de Médecine Interne (SA), Bobigny; Centre Hospitalier Victor Dupouy, Service de Pneumologie (J. Camuset), Argenteuil; Centre Hospitalier et Universitaire de Caen, Service de Médecine Interne (BB), Caen; Centre Hospitalier Universitaire de Grenoble, Service de Pneumologie, Pôle Thorax et Vaisseaux (MD), Grenoble; Hôpital Claude Huriez, Service de Médecine Interne (EH), Université Lille Nord-de-France, Lille; AP-HP, Hôpital Européen Georges Pompidou, Service de Médecine Interne (JBA), Paris; Centre Hospitalier Universitaire de Nantes, Hôtel-Dieu, Service de Médecine Interne (MH), Nantes; AP-HP, Hôpital Saint-Louis, Service de Médecine Interne (AM), Université Paris Diderot-Paris VII, Paris; AP-HP, Hôpital Saint-Louis, Service de Biostatistiques (MRR), Université Paris Did

Pulmonary fibrosis (PF) is an uncommon manifestation observed in patients with antineutrophil cytoplasmic antibodies (ANCA)-associated vasculitis (AAV), particularly microscopic polyangiitis (MPA). While patients with PF associated with AAV seem to have a worse prognosis, these patients have been described only in case reports or small retrospective case series. In this retrospective multicenter study, we report the main features and long-term outcomes of patients with PF associated with AAV, fulfilling the American College of Rheumatology criteria and/or Chapel Hill definitions. Read More

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http://dx.doi.org/10.1097/MD.0000000000000217DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4602438PMC
November 2014
51 Reads
10 Citations
5.723 Impact Factor

Chylous pericardial effusion in granulomatosis with polyangiitis.

Nephrology (Carlton) 2014 Jun;19(6):367-8

Division of Nephrology, Department of Pediatrics, University of British Columbia, Vancouver, Canada.

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http://dx.doi.org/10.1111/nep.12262DOI Listing
June 2014
5 Reads

[Delayed diagnosis in a case of granulomatosis with polyangiitis (Wegener's) with initial predominance of joint involvement].

Pneumologia 2014 Jan-Mar;63(1):53-9

The authors present the case of a 53-year-old female, initially admitted in a rheumatology department for fever and diffuse arthritis--being diagnosed with sero-positive rheumathoid arthritis. Although the chest X-ray and CT scan of thorax showed several abnormal features (medium lobe atelectasis, pseudo-cyst in the posterior segment of the right upper lobe with satellite milliary nodules, mediastinal lymph node enlargement), the investigations performed in our pneumology department couldn't establish the etiology of radiological abnormalities. With non-steroidal antiinflamatory treatment, the patient got worse, being readmitted in our hospital after 3 months for high fever, diffuse arthralgia with functional impairment, small hemoptysis, loss of hearing and left ear ache and on chest X-ray with bilateral macronodules, some of these with cavitation. Read More

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July 2014
2 Reads

Pulmonary manifestations of granulomatosis with polyangiitis.

Reumatol Clin 2014 Sep-Oct;10(5):288-93. Epub 2014 Feb 14.

Medicina Interna, Facultad de Medicina, Universidad Autónoma de San Luis Potosí, San Luis Potosí, México; Servicio de Reumatología, Hospital Central Dr. Ignacio Morones Prieto, San Luis Potosí, México. Electronic address:

Objective: To describe the clinical and laboratory data, with special emphasis on thoracic imaging findings, in 14 patients with a definitive diagnosis of granulomatosis with polyangiitis (GPA).

Methods: The clinical and tomographic data of 14 patients with a definitive diagnosis of GPA are presented. Patients with thoracic manifestations suggestive of GPA were evaluated in 3 hospitals from 2000 to 2012. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S1699258X140000
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http://dx.doi.org/10.1016/j.reuma.2013.12.010DOI Listing
June 2016
8 Reads

Coexistent pulmonary granulomatosis with polyangiitis (Wegener granulomatosis) and Crohn disease.

Am J Surg Pathol 2014 Mar;38(3):354-9

*Division of Thoracic Medicine #Department of Laboratory Medicine and Pathology, Mayo Clinic, Scottsdale, AZ †Section of Rheumatology, Dartmouth-Hitchcock Medical Center, Lebanon, NH Divisions of ‡Thoracic Medicine §Rheumatology ∥Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN ¶Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, MA.

Crohn disease (CD) may be associated with various extraintestinal manifestations, including, rarely, respiratory tract involvement. When necrobiotic pulmonary nodules are present, the differential diagnosis includes granulomatosis with polyangiitis (Wegener granulomatosis) (GPA). The respiratory tract manifestations of CD and GPA may mimic each other, complicating the diagnosis and suggesting the possible coexistence of these 2 conditions. Read More

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http://dx.doi.org/10.1097/PAS.0000000000000135DOI Listing
March 2014
4 Reads

Necrotizing sarcoid granulomatosis with an uncommon manifestation: clinicopathological features and review of literature.

Respir Care 2014 Sep 10;59(9):e132-6. Epub 2013 Dec 10.

Department of Cardiac, Thoracic and Vascular Sciences, University of Padua, Padua, Italy.

We report a rare case of an incidental diagnosis of necrotizing sarcoid granulomatosis (NSG) in a 60-y-old non-smoking male. The patient was admitted to the hospital for sudden back pain. Chest x-ray revealed areas of parenchymal consolidation and high-resolution computed tomography demonstrated a pulmonary nodular pattern with no lymph node enlargement. Read More

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http://rc.rcjournal.com/cgi/doi/10.4187/respcare.02842
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http://dx.doi.org/10.4187/respcare.02842DOI Listing
September 2014
19 Reads

Pulmonary post-transplant lymphoproliferative disorder with a CT halo sign.

Ann Transplant 2013 Sep 16;18:482-7. Epub 2013 Sep 16.

Department of Immunology, Transplantology, and Internal Medicine, Medical University of Warsaw, Warsaw, Poland.

Background: Post-transplant lymphoproliferative disease (PTLD) comprises a spectrum of clinically relevant lymphatic diseases that occur in patients after transplantation. The PTLD-related mortality is high and the clinical picture and location of the lesions are very variable. For these reasons, the diagnosis of PTLD is difficult and new diagnostic tools are sought. Read More

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http://dx.doi.org/10.12659/AOT.889354DOI Listing
September 2013
8 Reads

Integration of 2-deoxy-2-[18F] fluoro-D-glucose PET/CT into clinical management of patients with Wegener's granulomatosis.

Ann Nucl Med 2013 Dec 15;27(10):907-15. Epub 2013 Sep 15.

Department of Nuclear Medicine, Ataturk Chest Diseases and Thoracic Surgery Training and Research Hospital, Sanatoryum Cad., 06280, Kecioren, Ankara, Turkey,

Objective: Wegener's granulomatosis (WG) is a rare disorder characterized by granulomatous necrotizing vasculitis which mainly affects small- and medium-sized vessels. While the classical triad of involvement is upper and lower respiratory system and glomerulonephritis, WG may involve any organ or system in the body. The aim of our study was to investigate the role of positron emission tomography/computerized tomography (PET/CT) both in the initial evaluation and follow-up of patients with WG. Read More

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http://dx.doi.org/10.1007/s12149-013-0769-6DOI Listing
December 2013
44 Reads

Wegener granulomatosis--rare case presentation.

J Assoc Physicians India 2012 Oct;60:60-3

Dept. of Medicine, Karnataka Institute of Medical Science, Hubli.

Wegener granulomatosis is often misdiagnosed as pneumonia and most common cause for bilateral lung infiltrates' are bacterial, viral, pneumocystis jiroveci infection. We describe a 35 year old female with 15 days history of nasal obstruction, breathlessness and fever. Investigations in this patient revealed chronic necrotizing vasculitic and granulomatous lesion in nasal biopsy, vasculitic pauciimmune glomerulonephritis in renal biopsy, serology test was positive for C-ANCA, nodular with cystic lesion in CT-thorax. Read More

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October 2012
2 Reads

Intense FDG uptake on PET/CT in the upper and lower respiratory system indicative of Wegener's granulomatosis.

Rev Esp Med Nucl Imagen Mol 2014 Jan-Feb;33(1):32-5. Epub 2013 May 14.

Department of Chest Diseases, Faculty of Medicine, Bezmialem Vakif University, Istanbul, Turkey.

Wegener's granulomatosis (WG) is an uncommon systemic vasculitis, which involves the upper and lower respiratory tracts and the kidneys. Because the patients generally present with clinical manifestations that are similar to common diseases, WG may be initially misdiagnosed as infection or malignancy. We report the case of a 55-year-old male presenting with weight loss, cough, hemoptysis, low-grade fever, and pulmonary nodules detected on the thoracic CT scan. Read More

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http://dx.doi.org/10.1016/j.remn.2013.03.003DOI Listing
April 2015
2 Reads

Giant coronary artery aneurysms and eosinophilic granulomatosis with polyangiitis.

Arthritis Rheum 2013 May;65(5):1406

Eberhard Karls University Tübingen, Germany.

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http://dx.doi.org/10.1002/art.37898DOI Listing
May 2013
1 Read

Imaging findings in pulmonary vasculitis.

Semin Ultrasound CT MR 2012 Dec;33(6):567-79

Department of Radiology, UDIAT-Centre Diagnòstic, Institut Universitari Parc Taulí-UAB, Sabadell, Barcelona, Spain.

Vasculitis is a destructive inflammatory process affecting blood vessels. Pulmonary vasculitis may develop secondary to other conditions or constitute a primary idiopathic disorder. Thoracic involvement is most common in primary idiopathic large-vessel vasculitides (Takayasu arteritis, giant cell arteritis, Behçet disease) and primary antineutrophil cytoplasmic autoantibody-associated small-vessel vasculitides (Wegener granulomatosis, microscopic polyangiitis, Churg-Strauss syndrome). Read More

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http://dx.doi.org/10.1053/j.sult.2012.05.001DOI Listing
December 2012
12 Reads

Pathologic manifestations of Immunoglobulin(Ig)G4-related lung disease.

Semin Diagn Pathol 2012 Nov;29(4):219-25

Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota 55905, USA.

Immunoglobulin(Ig)G4-related disease (IgG4-RD) is a fibroinflammatory condition that can affect virtually any organ and usually presents as tumefactive lesions involving multiple sites. Characteristic histopathology of IgG4-RD consists of dense lymphoplasmacytic infiltrate, fibrosis (often in storiform pattern), and obliterative phlebitis, accompanied by tissue infiltration of IgG4-positive plasma cells with or without elevation of serum IgG4 level. Despite a general similarity in the morphologic manifestations of IgG4-RD, site-specific unique morphologic features have been described in some organs including the lung. Read More

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http://linkinghub.elsevier.com/retrieve/pii/S074025701200044
Publisher Site
http://dx.doi.org/10.1053/j.semdp.2012.07.002DOI Listing
November 2012
4 Reads

Wegener's granulomatosis with pulmonary fungal infection: a case report and brief review.

Authors:
Y He J Liu B Gao

J Int Med Res 2012 ;40(1):383-92

Department of Respiration, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, China.

Wegener's granulomatosis (WG) is an autoimmune, necrotizing granulomatous disease of unknown aetiology that affects small and medium blood vessels, and is usually recurrent. Infection is the most frequent cause of death in patients with WG. A case of WG with pulmonary fungal infection in a 50-year-old man is reported. Read More

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http://dx.doi.org/10.1177/147323001204000141DOI Listing
July 2012
1 Read

Common and uncommon manifestations of Wegener granulomatosis at chest CT: radiologic-pathologic correlation.

Radiographics 2012 Jan-Feb;32(1):51-69

Department of Radiology, Massachusetts General Hospital, 55 Fruit St, Founders 202, Boston, MA 02114, USA.

Wegener granulomatosis is an uncommon necrotizing vasculitis that classically manifests as a clinical triad consisting of upper and lower airway involvement and glomerulonephritis. Other less frequently involved organ systems include the central and peripheral nervous system and large joints. The diagnosis is based on a combination of clinical and laboratory findings. Read More

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http://dx.doi.org/10.1148/rg.321115060DOI Listing
May 2012
9 Reads

Isolated bladder vasculitis: a rare presentation of Wegener's granulomatosis.

W V Med J 2011 Jan-Feb;107(1):24-5

Department of Medicine, WVU Hospitals, Morgantown, USA.

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March 2011
2 Reads

[Atypical location of Wegener's granulomatosis with breast involvement: case report].

Ann Acad Med Stetin 2011 ;57(3):70-6

Klinika Reumatologii i Układowych Chorób Tkanki Łacznej Szpitala Uniwersyteckiego nr 2 im. dr. Jana Biziela w Bydgoszczy, Collegium Medicum Uniwersytetu Mikołaja Kopernika w Toruniu, ul. Ujejskiego 75, 85-168 Bydgoszcz.

Introduction: Wegener's granulomatosis is a disease of unknown etiology associated with the presence of serum antibodies against proteinase 3 in most cases. It is characterized by formation of inflammatory infiltrates presenting as granulomas with fibrinoid necrosis, as well as by ulceration and inflammation of small and medium-sized vessels with the involvement of upper and lower airways and kidneys. The process may also occur in other less typical locations, such as the gastrointestinal tract, heart, and nervous system. Read More

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March 2013
6 Reads

Wegener granulomatosis masquerading as pneumonia.

JBR-BTR 2010 Sep-Oct;93(5):264-6

Department of Radiology, Ioannina General Hospital, Ioannina, Greece.

We report a case of an elderly patient with a limited form of Wegener granulomatosis, which simulated the clinical and imaging features of organizing pneumonia. Here we call attention to this atypical case presentation that eloquently illustrates the many faces of Wegener granulomatosis. Read More

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January 2011
6 Reads

Manifestations of systemic diseases on thoracic imaging.

Curr Probl Diagn Radiol 2010 Nov-Dec;39(6):247-61

Department of Radiology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston MA 02115, USA.

A familiarity with the numerous findings in commonly encountered systemic diseases is necessary for the radiologist interpreting any chest study. These systemic diseases include collagen vascular diseases, vasculitides, granulomatous diseases, neoplasms, hematologic and metabolic abnormalities, neurocutaneous syndromes, deposition disease, and miscellaneous conditions such as cystic fibrosis and Goodpasture's syndrome. Although the imaging findings of these and other recognized systemic diseases are often nonspecific and varied, an understanding of their typical manifestations allows the radiologist to play a significant role in suggesting a particular diagnosis and impacting patient care. Read More

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http://dx.doi.org/10.1067/j.cpradiol.2009.07.008DOI Listing
January 2011
7 Reads

Dorsal prevertebral lesions in Wegener granulomatosis: report on four cases.

Joint Bone Spine 2011 Jan 18;78(1):88-91. Epub 2010 Sep 18.

Department of Internal Medicine, National Referral Center for Necrotizing Vasculitides and Systemic Sclerosis, Hôpital Cochin, Assistance publique-Hôpitaux de Paris, Université Paris Descartes, 27, rue du Faubourg Saint-Jacques, 75879 Paris cedex 14, France.

Retroperitoneal fibrosis has been reported in several patients with Wegener granulomatosis (WG), but only three isolated cases of dorsal prevertebral lesions, closely resembling fibrosing mediastinitis, have been published so far. We describe four new WG patients (two men, two women), 49-59 years old at diagnosis, with dorsal prevertebral lesions, mainly right-sided, and with adjacent pleural thickening in two. These lesions were detected on computed-tomography scans at diagnosis in two patients, and occurred later in the two others. Read More

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http://ac.els-cdn.com/S1297319X10002137/1-s2.0-S1297319X1000
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http://dx.doi.org/10.1016/j.jbspin.2010.07.017DOI Listing
January 2011
34 Reads

Images in thorax. The atoll sign.

Thorax 2010 Nov 6;65(11):1029-30. Epub 2010 Sep 6.

Department of Radiology, Royal Brompton Hospital, Sydney Street, London SW3 6NP, UK.

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http://dx.doi.org/10.1136/thx.2010.139360DOI Listing
November 2010
4 Reads

Multiple bilateral traumatic pulmonary pseuodocysts in a 53 year-old male diagnosed retrospectively.

Pneumologia 2010 Apr-Jun;59(2):84-6

Respiratory Medicine Division of Department of Medicine, Faculty of Medicine of Urmia, University of Medical Sciences, Urmia, West Azerbaijan, Iran.

Traumatic pulmonary pseudocyst (TPPC) is a rare complication, which might be encountered after thoracic trauma. It is most often (75-100%) seen in children and young adults. A 53 year-old male presented with multiple bilateral pulmonary cysts after a motor vehicle accident. Read More

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September 2010
2 Reads

Granulomatosis with polyangitis (Wegener's).

Thorax 2012 Jun 29;67(6):563-4. Epub 2010 Jul 29.

Department of Internal Medicine, Toyonaka Municipal Hospital, 4-14-1 Shibahara-cho, Toyonaka City, Osaka 560-8565, Japan.

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http://dx.doi.org/10.1136/thx.2009.133496DOI Listing
June 2012
3 Reads

When to suspect pulmonary vasculitis: radiologic and clinical clues.

Radiographics 2010 Jan;30(1):33-53

Department of Radiology, SDI UDIAT-CD, Institut Universitari Parc Taulí-UAB, Corporació Parc Taulí, Parc Taulí s/n, Sabadell, Spain.

Vasculitis is an inflammatory destructive process affecting blood vessels. Pulmonary vasculitis may be secondary to other conditions or constitute a primary, and in most cases idiopathic, disorder. Underlying conditions in the secondary vasculitides are infectious diseases, connective tissue diseases, malignancies, and hypersensitivity disorders. Read More

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http://dx.doi.org/10.1148/rg.301095103DOI Listing
January 2010
8 Reads

Spinal intradural haemorrhage in a patient with Wegener's Granulomatosis.

Clin Neurol Neurosurg 2010 May 6;112(4):341-3. Epub 2010 Jan 6.

Department of Neurosurgery, Addenbrooke's Hospital, Hills Road, Cambridge, UK.

We describe the case of a patient with known Wegener's Granulomatosis who developed a spontaneous intradural haematoma in the thoracic spine against a background of a recent relapse in her vasculitis. Decompression resulted in a rapid recovery of lower limb function. We propose involvement of the spinal meninges in the systemic vasculitis as the cause of haemorrhage. Read More

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http://dx.doi.org/10.1016/j.clineuro.2009.12.004DOI Listing
May 2010
3 Reads

[Case No. 4. Wegener's granulomatosis].

J Radiol 2009 Jul-Aug;90(7-8 Pt 1):865-9

Service de Radiologie, Hôpital Tenon, APHP, 4, rue de la Chine, 75970 Paris cedex 20.

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October 2009
3 Reads

Prompt plasmapheresis successfully rescue pulmonary-renal syndrome caused by ANCA-negative microscopic polyangiitis.

Clin Rheumatol 2009 Dec 28;28(12):1457-60. Epub 2009 Aug 28.

Division of Nephrology, Department of Internal Medicine, Tri-Service General Hospital, Number 325, Section 2, Cheng-Kung Road, Neihu 114, Taipei, Taiwan, Republic of China.

Pulmonary-renal syndrome (PRS) associated with antineutrophil cytoplasmic antibodies (ANCA)-negative microscopic polyangiitis (MPA) is relatively rare, and the effects of plasmapheresis on these patients remain unclear. Here, we report the case of a 66-year-old man who presented with fever, acute renal failure, thrombocytopenia, and sudden onset of diffuse pulmonary hemorrhage. Prompt plasmapheresis and concurrent pulse therapy with methylprednisolone effectively rescued his pulmonary-renal syndrome. Read More

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http://link.springer.com/10.1007/s10067-009-1264-2
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http://dx.doi.org/10.1007/s10067-009-1264-2DOI Listing
December 2009
54 Reads

Multifocal intravascular papillary endothelial hyperplasia in the retroperitoneum and spine: a case report and review of the literature.

J Magn Reson Imaging 2009 Apr;29(4):957-61

University of California, San Diego Medical Center, San Diego, California, USA.

The authors present a unique case of intravascular papillary endothelial hyperplasia (IPEH) localized in the renal hilum, retroperitoneum, and spine in a patient with Wegener granulomatosis. IPEH rarely occurs in the abdomen or spine with few cases reported in the literature. No case has been reported of IPEH involving both the retroperitoneum and spine. Read More

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http://dx.doi.org/10.1002/jmri.21724DOI Listing
April 2009
8 Reads

Wegener's granulomatosis in the chest: high-resolution CT findings.

AJR Am J Roentgenol 2009 Mar;192(3):676-82

Imaging Institute, Cleveland Clinic, 9500 Euclid Ave., Hb6, Cleveland, OH 44195, USA.

Objective: Wegener's granulomatosis is an uncommon necrotizing vasculitis having variable presentations in the chest that are best depicted on high-resolution CT. Imaging findings may include nodules, which may cavitate; ground-glass opacity secondary to pulmonary hemorrhage; and airway stenoses and ulcerations. Active Wegener's granulomatosis can mimic pneumonia, septic emboli, and metastases. Read More

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http://dx.doi.org/10.2214/AJR.08.1837DOI Listing
March 2009
4 Reads

[Atypical presentation of Wegener disease in childhood].

J Mal Vasc 2008 Dec 20;33(4-5):242-6. Epub 2008 Nov 20.

Service de pédiatrie, hôpital La Rabta, 1007 Tunis, Tunisia.

The pediatric forms of Wegener granulomatosis (WG) are rare. The clinical picture and the profile have specificities compared to those of adults. We report a case of a girl aged of four years and a half who presented initially with a clinical picture of Henoch Schönlein purpura. Read More

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http://linkinghub.elsevier.com/retrieve/pii/S039804990800364
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http://dx.doi.org/10.1016/j.jmv.2008.09.007DOI Listing
December 2008
3 Reads