65 results match your criteria Imaging in Transient Tachypnea of the Newborn


A rare complication of umbilical vein catheterization: TPNoma: US, X-ray, and MRI findings.

Curr Med Imaging 2022 Jun 20. Epub 2022 Jun 20.

Department of Radiology, Faculty of Medicine, Bezmialem Vakif University, Istanbul, Turkey.

Background: Umbilical vein catheterization (UVC) is an early venous access route in newborns and is frequently used for delivering total parenteral nutrition (TPN) and medications. Vascular, hepatic parenchymal, and infectious complications of UVC can be seen rarely.

Objective: We present preterm neonates' X-ray, US, and MRI findings with parenchymal TPN extravasation and portal vein thrombosis. Read More

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Tools for assessing lung fluid in neonates with respiratory distress.

BMC Pediatr 2022 Jun 20;22(1):354. Epub 2022 Jun 20.

Department of Pediatrics, Yonsei University College of Medicine, Seoul, Republic of Korea.

Background: Transient tachypnea of the newborn (TTN), as a common cause of neonatal respiratory distress, needs to be distinguished from respiratory distress syndrome (RDS). Various modalities such as lung ultrasonography, cytokine analysis, and electrical cardiometry for the evaluation of lung fluid can be helpful for the exact diagnosis, however, clinical diagnosis has been applied mainly. This study aimed to evaluate the usefulness of the various tools for the diagnosis of TTN and RDS in neonates. Read More

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Lung ultrasound in Italian neonatal intensive care units: A national survey.

Pediatr Pulmonol 2022 May 30. Epub 2022 May 30.

Department of Neurosciences Psychology Drug Research and Child Health, Careggi University Hospital of Florence, Florence, Italy.

Introduction: Lung ultrasound (LU) is a noninvasive, bedside imaging technique that is attracting growing interest in the evaluation of neonatal respiratory diseases. We conducted a nationwide survey of LU usage in Italian neonatal intensive care units (NICUs).

Methods: A structured questionnaire was developed and sent online to 114 Italian NICUs from June to September 2021. Read More

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Prenatal prediction of neonatal respiratory morbidity: a radiomics method based on imbalanced few-shot fetal lung ultrasound images.

BMC Med Imaging 2022 01 4;22(1). Epub 2022 Jan 4.

Department of Electronic Engineering, Fudan University, No. 220, Handan Road, Yangpu District, Shanghai, 200433, China.

Background: To develop a non-invasive method for the prenatal prediction of neonatal respiratory morbidity (NRM) by a novel radiomics method based on imbalanced few-shot fetal lung ultrasound images.

Methods: A total of 210 fetal lung ultrasound images were enrolled in this study, including 159 normal newborns and 51 NRM newborns. Fetal lungs were delineated as the region of interest (ROI), where radiomics features were designed and extracted. Read More

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January 2022

Fluid handling and blood flow patterns in neonatal respiratory distress syndrome versus transient tachypnea: a pilot study.

BMC Pediatr 2021 12 3;21(1):541. Epub 2021 Dec 3.

University of Calgary, Cumming School of Medicine, Libin Cardiovascular Institute of Alberta, Calgary, Canada.

Background: Cardiovascular and renal adaptation in neonates with Respiratory Distress Syndrome (RDS) and Transient Tachypnea of the Newborn (TTN) may be different.

Methods: Neonates ≥32 weeks were diagnosed with RDS or TTN based on clinical, radiologic and lung sonographic criteria. Weight loss, feeding, urine output, and sodium levels were recorded for the first 3 days, and serial ultrasounds assessed central and organ Doppler blood flow. Read More

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December 2021

The use of immature granulocyte and other complete blood count parameters in the diagnosis of transient tachypnea of the newborn.

Ann Med Surg (Lond) 2021 Dec 22;72:102960. Epub 2021 Oct 22.

Kastamonu Training and Research Hospital Pediatrics Clinic, Turkey.

Background: Although Transient tachypnea of the newborn (TTN) is one of the most common causes of respiratory distress in the newborn period, there is no laboratory parameter used to diagnose it. Immatur granulocyte (IG) measurement is accepted as a useful indicator that can be used in early detection of many infectious conditions, especially neonatal sepsis. In this study, it was aimed to determine if IG and other complete blood count (CBC) parameters could be used as laboratory findings supporting TTN diagnosis. Read More

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December 2021

Prediction of Lung Maturity in Fetuses with Growth Restriction through Quantitative Ultrasound Analysis.

Ultrasound Med Biol 2022 01 1;48(1):20-26. Epub 2021 Oct 1.

Department of Obstetrics, Paulista School of Medicine, Federal University of São Paulo (EPM-UNIFESP), São Paulo, Brazil.

The present study aimed to evaluate the performance of QuantusFLM software, which performs quantitative analysis of lung tissue texture through ultrasound images, in predicting lung maturity in fetal growth restriction (FGR). We included patients with singleton gestations between 34 and 38 6/7 wk and divided them into two groups: FGR and control (appropriate for gestational age [AGA]). The images were captured by ultrasound according to a specific protocol up to 48 h before delivery and analyzed with QuantusFLM software. Read More

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January 2022

The Associations Between Lung Ultrasonography Scores in the First Day of Life and Clinical Outcomes.

J Ultrasound Med 2022 Feb 19;41(2):417-425. Epub 2021 Apr 19.

Department of Pediatrics, Division of Neonatology, Zeynep Kamil Maternity and Children's Training and Research Hospital-Istanbul, University of Health Sciences, Istanbul, Turkey.

Objectives: To investigate the role of lung ultrasonography (LU) in predicting noninvasive ventilation (NIV) failure and the relationship between lung ultrasonography scores (LUS) with clinical outcomes in neonatal respiratory failure (NRF).

Methods: A prospective, cross-sectional study was conducted in newborns with NRF who needed NIV and were evaluated by LU. The first LUS (LUS1) was calculated at 2-6 hours and the second (LUS2) at 12-24 hours of life. Read More

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February 2022

Diagnostic performance of lung ultrasound for transient tachypnea of the newborn: A meta-analysis.

PLoS One 2021 29;16(3):e0248827. Epub 2021 Mar 29.

Department of Radiology, Children's Hospital of Fudan University, Shanghai, China.

Several recent studies demonstrated that lung ultrasound could achieve desired diagnostic accuracy for transient tachypnea of the neonate (TTN). However, the diagnostic performance of lung ultrasound for TTN has not been systematically studied to date. This meta-analysis aimed to investigate the performance of lung ultrasound in diagnosing TTN. Read More

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October 2021

Use of lung ultrasound in neonates during the COVID-19 pandemic.

Radiol Bras 2020 Nov-Dec;53(6):401-404

Instituto da Criança do Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo (ICr/HC-FMUSP), São Paulo, SP, Brazil.

In the current pandemic, caused by infection with severe acute respiratory syndrome coronavirus 2, ultrasound has played a fundamental role in patients who develop the resulting disease, designated coronavirus disease 2019 (COVID-19). In this study we present ultrasound images of the lungs of neonates with a suspected or confirmed diagnosis of COVID-19, distinguishing between the changes related to COVID-19 and those unrelated to the disease. Ultrasound examinations were performed by a pediatric sonographer. Read More

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December 2020

Prospective investigation of serial ultrasound for transient tachypnea of the newborn.

Pediatr Neonatol 2021 01 9;62(1):64-69. Epub 2020 Sep 9.

Division of Chest, Department of Pediatrics, Chang Gung Memorial Hospital, Linkou Branch, No. 5, Fuxing St., Guishan Dist., Taoyuan City 333, Taiwan, ROC. Electronic address:

Background: Transient tachypnea of the newborn (TTN), which is diagnosed using typical clinical course and radiographic findings, is the most common cause of respiratory distress in late-preterm and term neonates. Lung ultrasound (LUS) is increasingly used to identify TTN according to the distinct characteristics of the disease. However, few studies have reported the application of LUS to monitor the clinical evolution of TTN. Read More

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January 2021

Lung ultrasound features predict admission to the neonatal intensive care unit in infants with transient neonatal tachypnoea or respiratory distress syndrome born by caesarean section.

Eur J Pediatr 2021 Mar 19;180(3):869-876. Epub 2020 Sep 19.

Neonatal Intensive Care Unit, AOU Bologna, Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy.

We aimed to evaluate the reliability of lung ultrasound (LU) to predict admission to the neonatal intensive care unit (NICU) for transient neonatal tachypnoea or respiratory distress syndrome in infants born by caesarean section (CS). A prospective, observational, single-centre study was performed in the delivery room and NICU of Sant'Orsola-Malpighi Hospital in Bologna, Italy. Term and late-preterm infants born by CS were included. Read More

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Recent Advances in Pathophysiology and Management of Transient Tachypnea of Newborn.

J Perinatol 2021 01 4;41(1):6-16. Epub 2020 Aug 4.

Department of Pediatrics, Case Western Reserve University, UH Rainbow Babies & Children's Hospital, Cleveland, OH, USA.

Transient tachypnea of newborn (TTN) results from failure of the newborn to effectively clear the fetal lung fluid soon after birth. TTN represents the most common etiology of respiratory distress in term gestation newborns and sometimes requires admission to the neonatal intensive care unit. TTN can lead to maternal-infant separation, the need for respiratory support, extended unnecessary exposure to antibiotics and prolonged hospital stays. Read More

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January 2021

Isolated origin of one-branch pulmonary artery from aorta mimics transient tachypnea of the newborn.

Pediatr Int 2020 07 5;62(7):870-871. Epub 2020 Jul 5.

Department of Pediatric Cardiology, Bezmialem Vakif University, Istanbul, Turkey.

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Fetal Pulmonary Artery Acceleration/Ejection Ratio for Transient Tachypnea of the Newborn in Uncomplicated Term Small for Gestational Age Fetuses.

Eur J Obstet Gynecol Reprod Biol 2020 Apr 14;247:116-120. Epub 2020 Feb 14.

Department of Neonatology, Kayseri City Hospital, Kayseri, Turkey. Electronic address:

Objective: Transient tachypnea of the newborn (TTN) is the leading cause of neonatal morbidity in preterm deliveries and has been reported in term small-for-gestational-age (SGA) fetuses; therefore, determination of fetal lung maturity before delivery is extremely important. Our present study aimed to evaluate the ratio of fetal pulmonary artery acceleration time to ejection time (At/Et) in uncomplicated term SGA fetuses and whether this ratio changes with TTN.

Study Design: One hundred seventy-five pregnant women with uncomplicated pregnancies who delivered after 37 gestational weeks were included in this cross-sectional study. Read More

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Thoracic ultrasound accuracy for the investigation of initial neonatal respiratory distress.

Arch Pediatr 2019 Nov 17;26(8):459-465. Epub 2019 Oct 17.

Service d'imagerie médicale, hôpital Nord, AP-HM, 13015 Marseille, France.

Thoracic ultrasound (TUS) is increasingly studied in neonatal respiratory distress but chest x-ray (CXR) remains the first-line exam. We aimed to evaluate its diagnostic performance for the investigation of unselected causes of neonatal respiratory distress in daily practice. We conducted a descriptive, prospective, and single-center diagnostic accuracy study in a tertiary hospital, including term and preterm newborns who needed a CXR because of respiratory conditions occurring at birth or during the first 24h of life. Read More

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November 2019

Prone versus Supine Position for Lung Ultrasound in Neonates with Respiratory Distress.

Am J Perinatol 2021 01 3;38(2):176-181. Epub 2019 Sep 3.

Division of Neonatology, Department of Pediatrics and Child Health, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Canada.

Objective: To study the feasibility of lung ultrasound (LUS) in prone position and to compare it with supine position in neonates with respiratory distress.

Study Design: Neonates ≥ 29 weeks of gestational age with respiratory distress requiring respiratory support within first 12 hours of life were enrolled prospectively. First LUS (fLUS) was done in the position infant was nursed (supine or prone), infant's position changed, a second LUS (sLUS) was performed immediately and a third LUS (tLUS) was done 1 to 2 hours later. Read More

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January 2021

Neonatal Outcomes and Maternal Characteristics in Monochorionic Diamniotic Twin Pregnancies: Uncomplicated versus Twin-to-Twin Transfusion Syndrome Survivors after Fetoscopic Laser Surgery.

Fetal Diagn Ther 2020 21;47(2):165-170. Epub 2019 Aug 21.

The Fetal Center, Children's Memorial Hermann Hospital, Houston, Texas, USA,

Preterm birth remains a major complication of fetal laser surgery (FLS) due to twin-to-twin transfusion syndrome (TTTS).

Objectives: We tested the hypothesis that neonatal outcomes in fetuses born at >24 weeks are worse in TTTS survivors compared to uncomplicated monochorionic diamniotic (MCDA) twins.

Methods: 196 patients with TTTS treated with laser therapy and 91 uncomplicated MCDA gestations were compared. Read More

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November 2020

Accuracy of lung ultrasonography in the diagnosis of respiratory distress syndrome in newborns.

J Matern Fetal Neonatal Med 2021 Jan 22;34(2):281-286. Epub 2019 Apr 22.

Department of Neonatology, Faculty of Medicine, Hacettepe University, Ankara, Turkey.

Lung ultrasonography has become an important tool in the diagnosis and follow-up of lung diseases in the newborn period in recent years. Lung diseases such as pneumonia, transient tachypnea of the newborn and respiratory distress syndrome (RDS) can be diagnosed with lung ultrasound. Lung USG is a simple, practical and low-cost method in diagnosing neonatal RDS. Read More

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January 2021

A Multicenter Lung Ultrasound Study on Transient Tachypnea of the Neonate.

Neonatology 2019 7;115(3):263-268. Epub 2019 Feb 7.

Division of Neonatology, Department of Translational Medical Sciences, Università "Federico II", Naples, Italy.

Background And Aim: Discordant results that demand clarification have been published on diagnostic lung ultrasound (LUS) signs of transient tachypnea of the neonate (TTN) in previous cross-sectional, single-center studies. This work was conducted to correlate clinical and imaging data in a longitudinal and multicenter fashion.

Methods: Neonates with a gestational age of 34-40 weeks and presenting with TTN underwent a first LUS scan at 60-180 min of life. Read More

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December 2019

The utility of routine echocardiography in newborn infants with a persistent oxygen requirement

Ir Med J 2018 05 10;111(5):755. Epub 2018 May 10.

Department of Neonatology, the Rotunda Hospital, Dublin, Ireland.

In the era of antenatal screening for congenital heart disease (CHD), infants presenting with an undiagnosed significant CHD are rare. However, term infants admitted with an initial diagnosis of TTN and a prolonged oxygen requirement often undergo an echocardiogram. We aimed to assess whether this practice yields any additional cases of undiagnosed CHD. Read More

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Lung ultrasound in early diagnosis of neonatal transient tachypnea and its differentiation from other causes of neonatal respiratory distress.

J Neonatal Perinatal Med 2018 ;11(3):281-287

Departments of Pediatrics and Neonatology, Faculty of Medicine, Suez Canal University, Ismailia, Egypt.

Background: Transient tachypnea of the newborn (TTN) is one of the most common causes of neonatal respiratory distress (RD). However, distinguishing TTN from other causes of RD may be difficult during the first 12:24 h after birth. Lung ultrasonography (LUS) has been successfully utilized in the diagnosis and differential diagnosis of neonatal RD. Read More

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Pulmonary interstitial glycogenosis associated with a spectrum of neonatal pulmonary disorders.

Hum Pathol 2017 10 2;68:154-165. Epub 2017 Sep 2.

Division of Diagnostic Imaging, The Hospital for Sick Children and University of Toronto, Toronto, Ontario M5T 1W7, Canada.

Primary or isolated pulmonary interstitial glycogenosis (PIG) is a rare disease presenting as tachypnea and hypoxemia during the perinatal period. A diffuse interstitial infiltrate with focal hyperinflation is visible on chest imaging. The biopsy findings include diffuse expansion of the interstitium by spindle-shaped cells with pale cytoplasm that, on electron microscopy (EM), are poorly differentiated mesenchymal cells containing abundant monoparticulate glycogen. Read More

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October 2017

Role of chest ultrasound in neonatal lung disease: a review of current evidences.

J Matern Fetal Neonatal Med 2019 Jan 14;32(2):310-316. Epub 2017 Sep 14.

b Department of Pulmonology , Mofid Children's Hospital, Shahid Beheshti University of Medical Sciences , Tehran , Iran.

Among the common causes of neonatal admission to NICU, respiratory distress is one of the important causes. The neonatal respiratory distress is end result of various pulmonary and non-pulmonary causes. Differentiation of pulmonary causes of respiratory distress is important for the neonatologist as treatment differs with different etiologies. Read More

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January 2019

Perinatal outcomes in uncomplicated late preterm pregnancies with borderline oligohydramnios.

J Matern Fetal Neonatal Med 2018 Dec 16;31(23):3085-3088. Epub 2017 Aug 16.

d Department of Public Health , Erciyes Üniversitesi Faculty of Medicine , Kayseri , Turkey.

Purpose: The purpose of this study is to determine the adverse perinatal outcomes in uncomplicated late preterm pregnancies with borderline oligohydramnios.

Methods: A total of 430 pregnant women with an uncomplicated singleton pregnancy at a gestational age of 34 + 0-36 + 6 weeks were included. Borderline oligohydramnios was defined as an amniotic fluid index (AFI) of 5. Read More

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December 2018

Elevated airway liquid volumes at birth: a potential cause of transient tachypnea of the newborn.

J Appl Physiol (1985) 2017 Nov 3;123(5):1204-1213. Epub 2017 Aug 3.

The Ritchie Centre, Hudson Institute of Medical Research, Melbourne, Victoria, Australia;

Excessive liquid in airways and/or distal lung tissue may underpin the respiratory morbidity associated with transient tachypnea of the newborn (TTN). However, its effects on lung aeration and respiratory function following birth are unknown. We investigated the effect of elevated airway liquid volumes on newborn respiratory function. Read More

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November 2017

A non-invasive method to rule out transient tachypnea of the newborn (TTN): fetal pulmonary artery acceleration to ejection time ratio.

J Perinat Med 2018 Feb;46(2):219-224

Department of Obstetrics and Gynecology, Kayseri Training and Research Hospital, Kayseri, Turkey.

Objective: To investigate whether fetal pulmonary artery acceleration to ejection time (PATET) ratio can predict or rule out subsequent diagnosis of transient tachypnea of the newborn (TTN).

Methods: This prospective cohort study included 105 pregnant women in labor, who met the inclusion criteria. Eighteen of these women were removed from the study cohort, because of an inability to acquire sufficient Doppler waveforms and a longer duration of deliveries. Read More

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February 2018

Prediction of neonatal respiratory morbidity by quantitative ultrasound lung texture analysis: a multicenter study.

Am J Obstet Gynecol 2017 08 23;217(2):196.e1-196.e14. Epub 2017 Mar 23.

BCNatal, Barcelona Center for Maternal-Fetal and Neonatal Medicine (Hospital Clínic and Hospital Sant Joan de Déu), IDIBAPS, University of Barcelona, Barcelona, Spain; Centre for Biomedical Research on Rare Diseases (Centro de Investigación Biomédica en Red Enfermedades Raras), Barcelona, Spain.

Background: Prediction of neonatal respiratory morbidity may be useful to plan delivery in complicated pregnancies. The limited predictive performance of the current diagnostic tests together with the risks of an invasive procedure restricts the use of fetal lung maturity assessment.

Objective: The objective of the study was to evaluate the performance of quantitative ultrasound texture analysis of the fetal lung (quantusFLM) to predict neonatal respiratory morbidity in preterm and early-term (<39. Read More

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Diagnostic Performance of Point of Care Ultrasonography in Identifying the Etiology of Respiratory Distress in Neonates.

Indian J Pediatr 2017 Apr 21;84(4):267-270. Epub 2017 Jan 21.

Department of Radiology, MNJ Institute of Oncology and Regional Cancer, Hyderabad, India.

Objectives: To determine the diagnostic test performance of Point of care ultrasonography (PoC-USG) for identifying the etiology of respiratory distress (RD) in neonates when combination of radiological and clinical criteria is considered as the gold standard.

Methods: A neonate was included in the study if he/she had RD and underwent x-ray chest and ultrasound within 4 h of admission and the age was less than 24 h. The neonates admitted with non-respiratory illness were chosen as controls. Read More

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Routine application of lung ultrasonography in the neonatal intensive care unit.

Medicine (Baltimore) 2017 Jan;96(2):e5826

aDepartment of Neonatology and NICU of Bayi Children's Hospital,the Army General Hospital of the Chinese PLA affiliated to Southern Medical University, Beijing bDepartment of Pediatrics, Shenzhen Baoan Maternal and Child Health Hospital, Shenzhen, China.

The aim of this study was to study the features of lung ultrasonography (LUS) in lung disease and to evaluate the usefulness of LUS in the neonatal intensive care unit (NICU).All of 3405 neonates included in this study underwent an LUS examination. Diagnoses were based on medical history, clinical manifestation, laboratory examination, and signs on chest radiography (CR) and/or computed tomography (CT). Read More

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January 2017