Search Our Scientific Publications & Authors

Ann Thorac Surg 2019 Feb 11. Epub 2019 Feb 11.

Cerebrovascular Center, Neurological Institute, Cleveland Clinic, Cleveland, Ohio; Department of Neurology, NYU School of Medicine, New York, NY. Electronic address:

Background: Little data exists regarding reversal and resumption of antithrombotics following left ventricular assist device (LVAD)-associated intracranial hemorrhage (ICH).

Methods: Prospectively collected data of LVAD patients with ICH was reviewed. Coagulopathy reversal agents, antithrombotic regimens and thrombotic (venous thromboembolism, ischemic stroke, myocardial infarction) and hemorrhagic (recurrent ICH, gastrointestinal bleed, anemia requiring transfusion) complications were recorded. Read More

J Clin Med 2019 Feb 12;8(2). Epub 2019 Feb 12.

TENSOR-Team of NeuroSurgery-Oriented Reaserch, Jagiellonian University Medical College, 31-008 Kraków, Poland.

Tortuosity of blood vessels is a common angiographic finding that may indicate systemic disease and can be correlated with vascular pathologies. In this work, we determined whether patients with and without internal carotid artery (ICA) aneurysm presented with differences in its tortuosity descriptors. We retrospectively analysed data of 298 patients hospitalized between January 2014 and June 2018. Read More

Eur J Case Rep Intern Med 2018 28;5(8):000912. Epub 2018 Aug 28.

Vascular Neurology Department, Instituto Nacional de Neurologia y Neurocirugia, Mexico City, Mexico.

Background: Bilateral third cranial nerve palsy has only been reported in a handful of conditions including some with inflammatory, tumoural and vascular causes. An urgent imaging study is mandatory to rule out vascular aetiology, mainly aneurysmal subarachnoid haemorrhage (aSAH).

Case Presentation: A 28-year-old Hispanic woman presented to the emergency department with a 21-day history of a sudden-onset and severe headache that on three occasions was accompanied by transient loss of awareness, the last episode occurring a week previously. Read More

Eur J Case Rep Intern Med 2018 28;5(11):000961. Epub 2018 Nov 28.

Department of Internal Medicine, Centro Hospitalar do Meio Tejo, EPE, Tomar, Portugal.

Non-traumatic haematomyelia is a rare finding of acute onset, which in most cases is the result of arteriovenous malformations (AVM), tumours, coagulation disorders or autoimmune conditions, but may also be secondary to treatment with anticoagulants and radiotherapy. We present the case of a 58-year-old woman with sudden onset cervical pain, followed by asymmetric diminution of strength in the upper limbs with reduced pain sensitivity. The diagnosis of AVM at the C7 and D1 levels was made following cervico-dorsal magnetic resonance imaging and angiography. Read More

Crit Care 2019 Feb 11;23(1):42. Epub 2019 Feb 11.

Department of Anaesthesiology and Critical Care Medicine, INT (Institut de Neurosciences de la Timone), University Hospital Timone, Aix Marseille University, Marseille, France.

Background: Several lipid metabolites in cerebrospinal fluid are correlated with poor outcomes in aneurysmal subarachnoid haemorrhage. Most of these metabolites bind to ubiquitous thromboxane-prostaglandin (TP) receptors, causing vasoconstriction and inflammation. Here, we evaluated terutroban (TBN), a specific TP receptor antagonist, for the prevention of post-haemorrhage blood-brain barrier disruption, neuronal apoptosis and delayed cerebral hypoperfusion. Read More

J Clin Neurosci 2019 Feb 4. Epub 2019 Feb 4.

Neuroradiologische Klinik, Neurozentrum, Klinikum Stuttgart, Germany; Medical Faculty, University Duisburg-Essen, Germany.

Basilar perforator artery aneurysms (BAPA's) are an under-recognised cause of sub-arachnoid haemorrhage (SAH). We present our single centre experience of BAPA's and review of the literature. We performed a retrospective review of our prospectively maintained database to identify all BAPA's that presented acute SAH between February 2009 and February 2018. Read More

Neurosci Lett 2019 Jan 31;699:64-70. Epub 2019 Jan 31.

Neurosciences and Mental Health, SickKids Research Institute, Toronto, Canada; Division of Neurology, The Hospital for Sick Children, University of Toronto, Canada. Electronic address:

Recent evidence suggests that good neurological outcome in subarachnoid hemorrhage (SAH) does not equate to good neuropsychological and cognitive outcome. These individuals continue to face cognitive difficulties in tasks involving mental flexibility, short-term memory and attention, resulting in decreased independence in daily living and reduced ability to return to work. In the current study, we examined the functional connectivity profiles using magnetoencephalography (MEG) in SAH patients, versus controls, during a visual short-term memory, 1-back, task. Read More

J Stroke Cerebrovasc Dis 2019 Jan 30. Epub 2019 Jan 30.

Department of Neurosurgery, Fukuoka University, Fukuoka Japan.

Background: There are limited clinical studies of bilateral vertebral artery dissection (VAD).

Objective: To compare the characteristics, imaging findings, and treatments between patients with bilateral and unilateral VAD.

Methods: Between February 2007 and May 2017, 31 (mean age: 53. Read More

J Neurol Surg A Cent Eur Neurosurg 2019 Feb 1. Epub 2019 Feb 1.

Department of Neurosurgery, Tohoku University Graduate School of Medicine, Sendai, Japan.

Background:  Intracranial chondromas are extremely rare and represent only 0.2% of all intracranial primary neoplasms. The histologic appearance lacks nuclear atypism and mitoses, and it usually shows low growth potential, although these benign features do not necessarily imply a good prognosis. Read More

World Neurosurg 2019 Jan 29. Epub 2019 Jan 29.

Department of Neurology, Neurosurgery and Radiology, Rutgers University - Robert Wood Johnson Medical School, New Brunswick, NJ; Department of Neurology and Neurosurgery, Westchester Medical Center at New York Medical College, Valhalla, NY. Electronic address:

Background: Intrathecal (IT), intraventricular (IVt), and intracisternal administration of nicardipine deliver treatment directly into the central nervous system (CNS). This route of drug delivery is being investigated as a potential treatment of vasospasm following aneurysmal subarachnoid hemorrhage (aSAH).

Objective: The authors review the existing literature regarding the direct administration of nicardipine into the intracranial space for the treatment of vasospasm following aSAH. Read More

Curr Neurovasc Res 2019 Jan 29. Epub 2019 Jan 29.

Department of Neurosurgery, the First Affiliated Hospital of Chongqing Medical University, NO.1 of Youyi Rd, Yuzhong District, Chongqing. China.

Objective: With the aging of the world population, a growing number of elderly patients suffered from aneurysmal subarachnoid hemorrhage (aSAH). We aim to investigate the potential association between plasma ALT level and clinical complications of elderly aSAH patients, and explore its predictive value for clinical outcomes of elderly aSAH patients.

Patients And Methods: Between January 2013 and March 2018, 152 elderly aSAH patients were analyzed in this study. Read More

Redox Biol 2019 Feb 23;21:101121. Epub 2019 Jan 23.

Department of Neurosurgery, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan 646000, China; Neurosurgery Clinical Medical Research Center of Sichuan Province, Luzhou, Sichuan 646000, China; Nuclear Medicine and Molecular Imaging Key Laboratory of Sichuan Province, Luzhou, Sichuan 646000, China. Electronic address:

White matter injury (WMI) is associated with motor deficits and cognitive dysfunctions in subarachnoid hemorrhage (SAH) patients. Therapeutic strategy targeting WMI would likely improve the neurological outcomes after SAH. Low-density lipoprotein receptor-related protein-1 (LRP1), a scavenger receptor of apolipoprotein E (apoE), is able to modulate microglia polarization towards anti-inflammatory M2 phenotypes during inflammatory and oxidative insult. Read More

J Neurosurg 2019 Jan 25:1-8. Epub 2019 Jan 25.

1Department of Neurosurgery, University Hospital, University of Duisburg-Essen; and.

OBJECTIVEClinical data on secondary hemorrhagic complications (SHCs) in patients with aneurysmal subarachnoid hemorrhage (SAH) are sparse and mostly limited to ventriculostomy-associated SHCs. This study aimed to elucidate the incidence, risk factors, and impact on outcome of SHCs in a large cohort of SAH patients.METHODSAll consecutive patients with ruptured aneurysms treated between January 2003 and June 2016 were eligible for this study. Read More

Medicine (Baltimore) 2019 Jan;98(4):e14227

Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo.

Rationale: Brain metastases are extremely rare for patients with pancreatic adenocarcinoma due to the poor prognoses. In the present study, we reported 2 cases of pancreatic adenocarcinoma with brain metastases.

Patient Concerns: The 1st patient was diagnosed asymptomatic brain metastasis by a follow-up brain magnetic resonance imaging (MRI) due to a medical history of subarachnoid hemorrhage. Read More

Pediatr Neurosurg 2019 Jan 23:1-7. Epub 2019 Jan 23.

Department of Neurosurgery, Virginia Commonwealth University Health System, Richmond, Virginia, USA.

Background: The purpose of this study was to determine if a pediatric neurosurgical consultation for isolated linear skull fractures (ILSF) in pediatric patients with Glasgow Coma Scale (GCS) scores of ≥14 changed their management.

Methods: A 10-year retrospective chart review at a Level 1 Pediatric Trauma Center was performed. Exclusion criteria were age > 18 years, open, depressed, or skull base fractures, pneumocephalus, poly-trauma, any hemorrhage (intraparenchymal, epidural, subdural, subarachnoid), cervical spine fractures, penetrating head trauma, and initial GCS scores ≤13. Read More

J Am Coll Radiol 2019 Jan 17. Epub 2019 Jan 17.

Division of Neuroradiology, The Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins Medical Institutions, Baltimore, Maryland. Electronic address:

Purpose: The ACR Appropriateness Criteria recommend performing noncontrast head CT (NCCT) for patients with sudden severe headache ("worst headache of life" [WHOL] or "thunderclap headache" [TCH]). The aim of this study was to assess the value of NCCT scanning in patients with known migraine histories and WHOL or TCH. The hypothesis was that there would be little utility in performing emergency department (ED) NCCT scans in migraineurs without other red flags, even if they had WHOL or TCH. Read More

Curr Pain Headache Rep 2019 Jan 19;23(1). Epub 2019 Jan 19.

Department of Medicine, Neurology Division, Univ. of South Carolina School of Medicine-Greenville, Greenville Health System, 200 Patewood Dr., Suite #B350, Greenville, SC, 29615, USA.

Purpose Of Review: Here, we describe the four primary imaging modalities for identification of carotid artery dissection, advantages, limitations, and clinical considerations. In addition, imaging characteristics of carotid dissection associated with each modality will be described.

Recent Findings: Recent advances in etiopathogenesis describe the genetic factors implicated in cervical artery dissection. Read More

J Radiol Case Rep 2018 Sep 30;12(9):1-8. Epub 2018 Sep 30.

Department of Radiology, Ackershus University hospital, lorenskog, Norway.

Intra-cranial saccular aneurysms, also known as Berry aneurysms, have a well-known association with autosomal dominant polycystic kidney disease (ADPKD). Aneurysmal rupture can be the initial presentation of the disease. ADPKD has two types of gene mutations: PKD1 and PKD2. Read More

J Neuroinflammation 2019 Jan 15;16(1). Epub 2019 Jan 15.

Department of Neurosurgery, Zhujiang Hospital, Southern Medical University, The National Key Clinical Specialty, The Engineering Technology Research Center of Education Ministry of China, Guangdong Provincial Key Laboratory on Brain Function Repair and Regeneration, Guangzhou, 510282, China.

Background: Activated microglia-mediated neuroinflammation has been regarded as an underlying key player in the pathogenesis of subarachnoid hemorrhage (SAH)-induced early brain injury (EBI). The therapeutic potential of bone marrow mesenchymal stem cells (BMSCs) transplantation has been demonstrated in several brain injury models and is thought to involve modulation of the inflammatory response. The present study investigated the salutary effects of BMSCs on EBI after SAH and the potential mechanism mediated by Notch1 signaling pathway inhibition. Read More

J Neurosurg 2019 Jan 11:1-5. Epub 2019 Jan 11.

1Department of Neurologic Surgery, Mayo Clinic, Rochester.

OBJECTIVECavernous internal carotid artery (ICA) aneurysms are frequently diagnosed incidentally and the benign natural history of these lesions is well known, but there is limited information assessing the risk of growth in untreated patients. The authors sought to assess and analyze risk factors in patients with cavernous ICA aneurysms and compare them to those of patients with intracranial berry aneurysms in other locations.METHODSData from consecutive patients who were diagnosed with a cavernous ICA aneurysm were retrospectively reviewed. Read More

Neurochirurgie 2019 Jan 9. Epub 2019 Jan 9.

Department of neurosurgery, CHU de Caen, 14000 Caen, France; Inserm U1237 'physiopathology & imaging of neurological disorders', university of Caen Normandy, 14000 Caen, 14000, France; Université Caen Normandie, Medical School, 14000 Caen, France.

Introduction: Aneurysmal subarachnoid hemorrhage (SAH) is a devastating form of stroke, which often causes acute hydrocephalus requiring the insertion of an external ventricular drain (EVD). A major complication of aneurysmal SAH is delayed cerebral ischemia (DCI). As DCI is linked to the presence of blood within the subarachnoid space, it has been hypothesized that removing this blood may decrease the risk of DCI. Read More

Neurology 2019 Feb 11;92(7):e639-e647. Epub 2019 Jan 11.

From the Department of Neurology (E.A.R., A.B.S.), Massachusetts General Hospital, Boston; Department of Neurology (E.A.R., G.S.S.), Universidade Federal de São Paulo, Brazil; Hospital Israelita Albert Einstein (G.S.S.), São Paulo, Brazil; and Department of Neurology (M.A.T.), Hacettepe University, Ankara, Turkey.

Objective: To develop a method to distinguish reversible cerebral vasoconstriction syndrome (RCVS) from other large/medium-vessel intracranial arteriopathies.

Methods: We identified consecutive patients from our institutional databases admitted in 2013-2017 with newly diagnosed RCVS (n = 30) or non-RCVS arteriopathy (n = 80). Admission clinical and imaging features were compared. Read More

Front Endocrinol (Lausanne) 2018 17;9:723. Epub 2018 Dec 17.

Max Planck Institute of Psychiatry, Munich, Germany.

Growth hormone deficiency (GHD) results in an impaired health-related quality of life (HrQoL) and cognitive impairment in the attention and memory domain. GHD is assumed to be a frequent finding after brain injury due to traumatic brain injury (TBI), aneurysmal subarachnoid hemorrhage (SAH) or ischemic stroke. Hence, we set out to investigate the effects of growth hormone (GH) replacement therapy in patients with isolated GHD after brain injury on HrQoL, cognition, and abdominal fat composition. Read More

Ugeskr Laeger 2019 Jan;181(2)

This review states the reasons for considering screening for intracranial aneurysms in Denmark: if patients have two first-degree relatives with intracranial aneurysms, are 30-70 years old, do not have competing disorders, which could significantly shorten life expectancy, and subsequently in patients with autosomal dominant kidney disease and a family history of subarachnoid haemorrhage. MR angiography should be the imaging study of choice, unless contraindicated. Generally, the ethical consequences ought to be considered before carrying out screening. Read More

J Neurosurg Pediatr 2019 Jan 4:1-6. Epub 2019 Jan 4.

2Neurology, The Affiliated Hospital of Hangzhou Normal University, Hangzhou City, Zhejiang Province, China.

OBJECTIVEMechanical thrombectomy using a Solitaire stent retriever has been widely applied as a safe and effective method in adult acute ischemic stroke (AIS). However, due to the lack of data, the safety and effectiveness of mechanical thrombectomy using a Solitaire stent in pediatric AIS has not yet been verified. The purpose of this study was to explore the safety and effectiveness of mechanical thrombectomy using a Solitaire stent retriever for pediatric AIS. Read More

J Neurosurg 2019 Jan 4:1-8. Epub 2019 Jan 4.

2Department of Neurological Surgery, University of Virginia, Charlottesville, Virginia.

OBJECTIVEIn this multicenter study, the authors reviewed the results obtained in patients who underwent Gamma Knife radiosurgery (GKRS) for dural arteriovenous fistulas (dAVFs) and determined predictors of outcome.METHODSData from a cohort of 114 patients who underwent GKRS for cerebral dAVFs were compiled from the International Gamma Knife Research Foundation. Favorable outcome was defined as dAVF obliteration and no posttreatment hemorrhage or permanent symptomatic radiation-induced complications. Read More

J Neurosurg Anesthesiol 2019 Jan 2. Epub 2019 Jan 2.

Neuro Imaging and Interventional Radiology, National Institute of Mental Health and Neurosciences, Bengaluru.

Background: Intra-arterial nimodipine (IaN) is used in the management of cerebral vasospasm after aneurysmal subarachnoid hemorrhage (aSAH). The impact of IaN therapy on regional cerebral oxygen saturation (rScO2) assessed by near infra-red spectroscopy, and dynamic cardiac indices, is currently unknown. This study assessed the effect of IaN on rScO2 and systemic hemodynamic indices during IaN therapy for cerebral vasospasm after aSAH. Read More

Stroke 2019 Feb;50(2):520-523

From the Neuroprotection Research Laboratory, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA (T.G., C.G., Y.Z., E.H.L., K.v.L.).

Background and Purpose- Subarachnoid hemorrhage (SAH) is a devastating form of stroke. Oxidative stress contributes to brain injury, but the mechanisms have been poorly studied. Here, we evaluated the role of 12/15-lipoxygenase (12/15-LOX), an enzyme known to cause cell death in ischemic stroke, on brain injury in a mouse model of SAH. Read More

J Clin Neurosci 2018 Dec 26. Epub 2018 Dec 26.

Department of Neurosurgery, United States. Electronic address:

This case report describes a 48-year old female who presented with altered mental status, lower extremity weakness, low back pain and a recent history of subjective fevers and night sweats found to have posterior parieto-occipital and spinal subarachnoid hemorrhage on imaging. Further work-up revealed vasculitic changes in the intracranial vasculature and the external carotid artery on angiography. She also demonstrated positivity for perinuclear anti-neutrophil cytoplasmic (p-ANCA) antibodies overall consistent with ANCA associated central nervous system vasculitis (AAV). Read More

J Neurosurg 2018 Dec 21:1-12. Epub 2018 Dec 21.

1Service de Neuroradiologie, Hôpital Pierre-Paul Riquet, CHU de Toulouse; and.

OBJECTIVEThe purpose of this study is to present the authors' medium-term results, with special emphasis on complications, occlusion rate of the aneurysm sac (digital subtraction angiography [DSA] and MRI), and the fate of cortical branches and perforating arteries covered ("jailed") by the flow diverter (FD) stent.METHODSBetween January 2010 and September 2017, 29 patients (14 female) with 30 aneurysms were treated with an FD stent. Twenty-one aneurysms were at the middle cerebral artery bifurcation, 8 were in the anterior communicating artery region, and 1 was a pericallosal artery bifurcation. Read More

No Shinkei Geka 2018 Dec;46(12):1087-1091

Stroke Center, Yamagata City Hospital SAISEIKAN.

Recent advances in digital subtraction angiography(DSA)and 3D-CT angiography(3D-CTA)have enabled the identification of tiny intracranial aneurysms. However, the imaging of blood blister-like aneurysms(BBAs)in the internal carotid artery(ICA)is still challenging. We report the case of a subarachnoid hemorrhage(SAH)with a ruptured BBA in the ICA that was revealed by magnetic resonance vessel wall imaging(MR-VWI). Read More

Neurol Med Chir (Tokyo) 2019 Jan 18;59(1):27-32. Epub 2018 Dec 18.

Department of Neurosurgery, Sapporo Medical University.

Epilepsy after aneurysmal subarachnoid hemorrhage (post-SAH epilepsy) is a critical complication that influences clinical and social prognoses. However, the underlying mechanisms remain unclear. We investigated the relationship between hemosiderosis and the incidence of post-SAH epilepsy. Read More

BMC Neurol 2018 Dec 18;18(1):210. Epub 2018 Dec 18.

Department of Neurology, Charité - Universitätsmedizin Berlin, Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin Institute of Health, Berlin, Germany.

Background: Cortical ischemic lesions represent the predominant pathomorphological pattern of focal lesions after aneurysmal subarachnoid hemorrhage (aSAH). Autopsy studies suggest that they occur adjacent to subarachnoid blood and are related to spasm of small cortical rather than proximal arteries. Recent clinical monitoring studies showed that cortical spreading depolarizations, which induce cortical arterial spasms, are involved in lesion development. Read More

Medicine (Baltimore) 2018 Dec;97(50):e13401

Department of Physical Medicine and Rehabilitation, College of Medicine, Yeungnam University, Daegu, Republic of Korea.

Rationale: A few studies using diffusion tensor tractography (DTT) have demonstrated recovery of injured corticoreticulospinal tract (CRT) in patients with intracerebral hemorrhage and infarct. However, no study reported on a patient who showed peri-infarct reorganization of an injured CRT following a middle cerebral artery territory infarct.

Patient Concerns: A 56-year-old right-handed male patient was diagnosed as spontaneous subarachnoid hemorrhage (SAH) and intraventricular hemorrhage (IVH) and underwent clipping for a ruptured anterior communicating artery aneurysm and right frontal extraventricular drainage for IVH at the department of neurosurgery of a university hospital. Read More

Neurol Med Chir (Tokyo) 2019 Jan 15;59(1):19-26. Epub 2018 Dec 15.

Department of Molecular Pharmacology, Research Institute, National Cerebral and Cardiovascular Center.

Subarachnoid hemorrhage due to rupture of a pre-existing intracranial aneurysm has quite a poor outcome in spite of intensive medical care. Hemodynamic stress loaded on intracranial arterial walls is considered as a trigger and a regulator of formation and progression of the disease, but how intracranial arterial walls or intracranial aneurysm walls behave under hemodynamic stress loading remains unclear. The purpose of this study was to visualize and analyze the wall motion of intracranial aneurysms to detect a pathological flow condition. Read More

J Neurointerv Surg 2018 Dec 14. Epub 2018 Dec 14.

Institute of Neurological Sciences, Prince of Wales Hospital, Randwick, New South Wales, Australia.

Background: The Pipeline Embolisation Device with Shield technology (PED-Shield) is suggested to have reduced thrombogenicity. This reduced thrombogenicity may make it possible to use safely in the acute treatment of aneurysmal subarachnoid haemorrhage (aSAH) on single antiplatelet therapy (SAPT).

Objective: To evaluate the safety and efficacy of the off-label use of PED-Shield with SAPT for the acute treatment of aSAH. Read More

Acta Neurol Belg 2018 Dec 11. Epub 2018 Dec 11.

Department of Neurology, CHU Nîmes, Hôpital Caremeau, Nîmes University Hospital, 4, Rue du Pr Debré, 30029, Nîmes Cedex 4, France.

Subarachnoid hemorrhage extension (SAHE) in the acute phase of cerebral amyloid angiopathy (CAA)-related lobar hemorrhage (LH) assessed by CT is very frequent. Recently, SAHE, together with finger-like projections on CT and ApoE4, has been used in a prediction model for histopathologically proven CAA showing excellent discrimination. Our aim was to analyze SAHE on MRI in the acute and subacute phase of LH in patients with and without associated hemorrhagic features supportive of CAA (i. Read More

J Neurol Surg Rep 2018 Oct 7;79(4):e93-e97. Epub 2018 Dec 7.

Department of Neurosurgery, Kantonsspital Aarau (KSA), Aarau, Switzerland.

Microsurgical clip ligation is considered a definitive treatment for intracranial aneurysms (IAs), resulting in low rates of local recurrence that range from 0.2 to 0.5% and a latency period that averages about a decade. Read More

J Neurointerv Surg 2018 Dec 7. Epub 2018 Dec 7.

Department of Neuroradiology, University Hospital Aachen, Aachen, Germany.

Background: To place a stent retriever for thrombectomy in acute ischemic stroke, the clot has to be passed first. A microwire is usually used for this maneuver. As an alternative, a wireless microcatheter can be used to pass the clot. Read More

World Neurosurg 2018 Dec 6. Epub 2018 Dec 6.

Department of Neurosurgery, Shinshu University School of Medicine, Matsumoto, Japan.

Superficial siderosis (SS) associated with craniopharyngioma is an extremely rare occurrence. To our knowledge, only three cases have been reported in literature. Two of the cases occurred following resection of the tumor. Read More

Neurocrit Care 2018 Dec 5. Epub 2018 Dec 5.

Cerebrovascular Center, Neurological Institute, Cleveland Clinic, Cleveland, OH, USA.

Background: The radiographic appearance of infectious intracranial aneurysms (IIAs) of infective endocarditis (IE) on magnetic resonance imaging (MRI) of brain is varied. We aimed to describe the IIA-specific MRI features in a series of patients with IIAs.

Methods: Records of patients with active IE who had digital subtraction angiography (DSA) at a tertiary medical center from January 2011 to December 2016 were reviewed. Read More

Cureus 2018 Sep 28;10(9):e3383. Epub 2018 Sep 28.

Neurosurgery, Advocate Christ Medical Center, Oak Lawn, USA.

Arachnoid cysts (ACs) are congenital, extra-axial lesions containing fluid similar to the composition of cerebrospinal fluid. Usually found incidentally, these lesions are observed with serial imaging to document their growth patterns and stability, and are then followed conservatively until clinical symptoms develop. Surgical options for symptomatic arachnoid cysts include cyst aspiration, cyst evacuation with fenestration into the subarachnoid space, and shunt procedures including cysto-peritoneal and cysto-ventricular shunts. Read More

J Neuroradiol 2018 Dec 1. Epub 2018 Dec 1.

Department of Diagnostic Radiology, Kaohsiung Chang-Gung Memorial Hospital Kaohsiung, Taiwan; College of Medicine, Chang Gung University, Taoyuan, Taiwan.

Background And Purpose: Spontaneous delayed migration of the flow-diverter stent (FD) is an unusual complication that can be fatal. The purpose of this study is to report our experience and review the literature for the management of delayed FD migration.

Materials And Methods: Between November 2013 and June 2017, 122 patients treated by FD at our institution were enrolled. Read More

BMC Neurol 2018 Nov 29;18(1):197. Epub 2018 Nov 29.

China-Japan Union Hospital of Jilin University, Jilin, China.

Background: The majority of ruptured intracranial aneurysms are combined with subarachnoid hemorrhage, but patients with only intracerebral hematoma without any subarachnoid hemorrhage are extremely rare.

Case Presentation: The patient was hospitalized due to sudden dizziness combined with slurred speech. The patient showed considerable decreased physical activity without any nuchal rigidity. Read More

Cell Transplant 2018 Nov 29:963689718815820. Epub 2018 Nov 29.

1 Department of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, China.

Vascular cognitive impairment (VCI) defines an entire spectrum of neurologic disorders from mild cognitive impairment to dementia caused by cerebral vascular disease. The pathogenesis of VCI includes ischemic factors (e.g. Read More

Neuroradiology 2019 Jan 28;61(1):97-102. Epub 2018 Nov 28.

Department of Interventional Neuroradiology, Beijing Tiantan Hospital, Capital Medical University, The No.6, Tiantan Xili, Dongcheng District, Beijing, China.

Purpose: The aim of our study is to report the peri-procedural complications and long-term stroke recurrent rate of symptomatic intracranial atherosclerosis (ICAS) patients who underwent submaximal primary angioplasty.

Methods: This is a retrospective analysis of consecutive patients in a single center who underwent submaximal primary angioplasty between January 1, 2012 and December 31, 2015. The peri-procedural complications and long-term outcomes are reported. Read More

Nervenarzt 2018 Nov 28. Epub 2018 Nov 28.

Institut für Neuroradiologie, Goethe-Universität, Schleusenweg 2-16, 60528, Frankfurt am Main, Deutschland.

Background: Hypertrophic olivary degeneration (HOD) occurs as a result of a lesion in the anatomical functional loop of the Guillain-Mollaret triangle. Frequent causes are intracerebral hemorrhage and brain infarction. After a latent period of weeks to months after the index event a hyperintensity can initially be observed in magnetic resonance imaging T2/FLAIR-weighting and finally an enlargement of the affected olive. Read More

Curr Neurovasc Res 2018 ;15(4):312-325

Cannon Stroke and Vascular Research Center, University at Buffalo, Buffalo, NY 14260, United States.

Background: The neurovasculature dynamically responds to changes in cerebral blood flow by vascular remodeling processes. Serial imaging studies in mouse models could help characterize pathologic and physiologic flow-induced remodeling of the Circle of Willis (CoW).

Method: We induced flow-driven pathologic cerebral vascular remodeling in the CoW of mice (n=3) by ligation of the left Common Carotid Artery (CCA), and the right external carotid and pterygopalatine arteries, increasing blood flow through the basilar and the right internal carotid arteries. Read More

Brain Res Bull 2019 Jan 24;144:85-91. Epub 2018 Nov 24.

Department of Nuclear Medicine and Radiology, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan.

Early brain injury and related cardiac consequences play a key role in the devastating outcomes after subarachnoid hemorrhage (SAH). We reported that rapamycin exerts neuroprotection against cortical hypoxia early after SAH, but its mechanism is poorly understood. This in vivo study aimed to determine the potential role of the transcription factor STAT3 in the rapamycin-mediated neuroprotection in a mouse model of SAH. Read More

Neurosurgery 2018 Nov 23. Epub 2018 Nov 23.

Department of Neurosurgery, Barrow Neurological Institute, St. Joseph's Hospital and Medical Center, Phoenix, Arizona.

Background: Ruptured aneurysms causing intraventricular hemorrhage (IVH) are associated with high morbidity. The presence of blood that completely fills the fourth ventricle (cast fourth ventricle, CFV) is thought to be particularly ominous, but studies documenting the outcome of such cases are lacking.

Objective: To investigate the outcomes of patients with aneurysmal subarachnoid hemorrhage (aSAH) and CFV. Read More