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J Neurosurg Case Lessons 2022 May 30;3(22):CASE22141. Epub 2022 May 30.

Norton Neuroscience Institute.

Background: Ependymomas are the most frequent tumors of the adult spinal cord, representing 1.9% of all central nervous system tumors and 60% of spinal cord tumors. Spinal ependymomas are usually solitary, intramedullary lesions. Read More

J Radiol Case Rep 2022 Mar 1;16(3):15-22. Epub 2022 Mar 1.

Anatomical Pathology Department, Faculty of Medicine, Universitas Airlangga, Indonesia.

Intramedullary cavernous angioma is a rare vascular malformation compared to cerebral cavernous malformation. The incidence of cavernous angioma is about 3 - 5% of all central nervous system lesions, 5 - 12% of all spinal vascular lesions, and 1% of all intramedullary lesions in pediatric patients. Although intramedullary cavernous angioma has the same histological picture as cerebral cavernous angioma, the natural history, and surgical approach are different from cerebral cavernous angioma. Read More

Childs Nerv Syst 2022 Apr 25. Epub 2022 Apr 25.

Department of Pathology, Chonnam National University Medical School, Chonnam National University Hwasun Hospital, Gwangju, Republic of Korea.

Introduction: Neurofibromatosis type 2 (NF-2) is an inherited disease, linked with abnormalities in the NF-2 gene, which is located on chromosome 22 and involved in merlin production. Many craniospinal tumors are common in individuals with NF-2. We present a case of NF-2 with the rapid symptomatic progression of multiple craniospinal tumors. Read More

J Chiropr Med 2021 Sep 6;20(3):170-175. Epub 2022 Apr 6.

Department of Neurosurgery, Cancer Institute of New Jersey, Rutgers University, New Brunswick, New Jersey.

Objective: The purpose of this case report is to describe the presentation of a patient with bilateral lumbar radiculopathy secondary to myxopapillary ependymoma.

Clinical Features: A 45-year-old man presented to a chiropractic office for evaluation and treatment of chronic lower back pain with bilateral lower extremity radiation. The initial onset of pain was related to a lifting injury 6 years prior that never fully resolved. Read More

Spinal Cord Ser Cases 2022 04 22;8(1):43. Epub 2022 Apr 22.

Department of Neurological Surgery, Lenox Hill Hospital, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, New York, NY, USA.

Introduction: Spinal myxopapillary ependymomas (SME) are rare WHO grade II neoplasms of the spinal cord. Despite their good prognosis, they have a high propensity for metastasis and recurrence, although the presentation of SME as multifocal is uncommon.

Case Presentation: Here we describe a rare case of a 34-year-old man who presented with painful bilateral radiculopathy with sexual dysfunction and altered sensation with defecation. Read More

Beijing Da Xue Xue Bao Yi Xue Ban 2022 Apr;54(2):315-319

Department of Neurosurgery, Peking University Third Hospital, Beijing 100191, China.

Objective: To explore the feasibility and key technology of microscopic resection of lumbar intraspinal tumor through microchannel keyhole approach.

Methods: The clinical features, imaging characteristics and surgical methods of 54 cases of lumbar intraspinal tumor which were microscopically operated by microchannel from February 2017 to September 2019 were reviewed and analyzed. There were 8 cases of extradural tumor, 3 cases of extra-and intradural tumor and 43 cases of subdural extramedullary tumor (including 3 cases of ventral spinal tumor). Read More

Neurol Med Chir (Tokyo) 2022 Jun 7;62(6):300-305. Epub 2022 Apr 7.

Department of Neurosurgery, Osaka Medical and Pharmaceutical University.

Spinal intramedullary tumors such as ependymoma or vascular lesions such as cavernous malformation are often at risk of intramedullary hemorrhage. Surgical procedures involving the high cervical spinal cord are often challenging. This technical note included four patients who presented with acute, subacute, or gradual onset of spinal cord dysfunction associated with intramedullary hemorrhage at the C1 or C1/2 level of the high cervical spine. Read More

J Int Med Res 2022 Mar;50(3):3000605221082889

Department of Neurosurgery, Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua University, Beijing 102218, P.R. China.

Background: Spinal ependymoma is the most common intramedullary tumor in adults. This study was performed to evaluate whether intraoperative yellow fluorescence use enhances our ability to identify the tumor margin and residual tumor tissue in intramedullary spinal cord ependymoma resection. We also evaluated patients' clinical conditions at a 3-month follow-up. Read More

Niger J Clin Pract 2022 Feb;25(2):197-199

Department of Neurosurgery, Fırat University, Elazığ, Turkey.

In patients with type 1 neurofibromatosis (NF1), there is an increased susceptibility to tumor development in the central nervous system due to the loss of neurofibromin, an inactivator of the protooncogene Ras. NF1 has a broad clinical spectrum,which includes spinal tumors. Although the most common intramedullary tumor of the spinal cord in adults is ependymoma, few patients with NF1 accompanied by spinal ependymoma have been reported to date, and the localization of the tumors is cervical and thoracic in these cases. Read More

Indian J Radiol Imaging 2021 Oct 10;31(4):1057-1061. Epub 2022 Jan 10.

Department of Spine Surgery, Ganga Hospital, Coimbatore, Tamil Nadu, India.

Cauda equina intradural tumors commonly reported include ependymoma, schwannoma, neurofibroma, meningioma, and drop metastasis. Hemangioblastoma of the neural axis is a rare benign vascular tumor comprising only 1.6 to 6. Read More

Medicine (Baltimore) 2022 Jan;101(4):e28682

Department of Radiology, Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua University, Beijing, China.

Abstract: This is a retrospective study. The aim of this study was to determine the indicators of neurological outcome after surgery in patients with intramedullary spinal ependymomas by using magnetic resonance imaging (MRI).A total of 106 consecutive patients (mean age: 42. Read More

Clin Neuropathol 2022 Mar-Apr;41(2):66-73

Paraganglioma that involves the CNS may mimic clinico-radiologically many other commoner entities. The current study presents a wide view of the clinical, radiological, and histomorphological spectrum along with rare associations that can occur concurrently with this lesion. The most common site of infliction in CNS is the spine and, in the current series, involvement of the lumbar spine was most frequent. Read More

Cureus 2021 Dec 10;13(12):e20329. Epub 2021 Dec 10.

Neurosurgery, Vasal Hospital Neuro and Trauma Centre, Jalandhar, IND.

Ependymomas are commonly reported at an intradural intramedullary location and more frequently at the conus medullaris or filum terminale. In comparison to this, the incidence of spinal tumors being reported at an intradural extramedullary site is less. We describe a young patient who presented with urinary retention and a long-standing history of back pain radiating to the right lower limb. Read More

BMJ Case Rep 2021 Nov 9;14(11). Epub 2021 Nov 9.

Neurosurgery, University of Puerto Rico Medical Sciences Campus, San Juan, Puerto Rico.

Sacral spinal cord ependymoma is an uncommon pathology. Most of the reported cases are consistent with a myxopapillary ependymoma histopathologic subtype. Non-myxopapillary ependymomas rarely occur in the sacral region. Read More

Radiol Case Rep 2021 Dec 10;16(12):3838-3843. Epub 2021 Oct 10.

Radiology Department, Rush University Medical Center, Chicago, Illinois, USA.

Myxopapillary ependymoma (MPE) is a unique slow-growing benign (WHO grade 1) subtype of spinal cord ependymoma arising predominantly in the filum terminale. Despite its benign nature, it occasionally disseminates through the cerebrospinal fluid and metastasizes to distant sites. Here, we report an extremely rare case of MPE with interval CSF seeding and metachronous metastasis in a 47 -year-old female presented as a gradually increasing low back pain for three months with bilateral radiculopathy down to the knees. Read More

Indian J Pathol Microbiol 2021 Oct-Dec;64(4):633-637

Department of Neurosurgery, GIPMER, Jawaharlal Nehru Marg, New Delhi, India.

Background: Tanycytic ependymoma (TE) (WHO grade II) is a rare and morphologically distinct variant of ependymoma with only 77 cases reported worldwide so far. Variable clinical and radio-pathological features lead to misdiagnosis as WHO grade 1 tumors. On imaging, differentials of either schwannoma, meningioma, low-grade glial (like angiocentric glioma), or myxopapillary ependymoma are considered. Read More

Pan Afr Med J 2021;39:164. Epub 2021 Jul 1.

Service de Neurochirurgie, Hôpital Militaire d'Instruction Mohammed V, Faculté de Médecine et de Pharmacie, Université Mohammed V de Rabat, Rabat, Maroc.

Indian J Pathol Microbiol 2021 Jul-Sep;64(3):591-593

Department of Pathology, AFMC, Wanowrie, Pune, Maharashtra, India.

Oper Neurosurg (Hagerstown) 2021 Sep;21(4):E357

Division of Pediatric Neurosurgery, Department of Surgery, Texas Children's Hospital, Houston, Texas, USA.

Extensive multifocal intradural lesions in children present a formidable challenge. This surgical video illustrates our management of a 14-yr=old boy with two intradural mass lesions on magnetic resonance imaging (MRI): one at T2-5 and the other from T12 through the sacral cul-de-sac. In a single procedure, we performed a T2-5 laminectomy and laminoplasty and T12-sacrum laminectomy for tumor resection. Read More

Childs Nerv Syst 2022 01 14;38(1):223-227. Epub 2021 Jun 14.

Department of Neurosurgery, Division of Pediatric Neurosurgery, Northwestern University Feinberg School of Medicine/Ann and Robert H. Lurie Children's Hospital, 225 E. Chicago Avenue, Chicago, IL, 60611, USA.

A 6-year-old girl presented with a 1-week history of progressive upper and lower extremity weakness and bilateral upper extremity dysesthesia. Imaging demonstrated a 4.7 × 1. Read More

Pan Afr Med J 2021 4;38:128. Epub 2021 Feb 4.

Service de Neurochirurgie du Centre Hospitalier Universitaire Yalgado Ouédraogo de Ouagadougou, Ouagadougou, Burkina Faso.

Intraspinal tumors are uncommon. Positive diagnosis is based on medical imaging exams, in particular MRI. Anatomopathological examination allows for definitive diagnosis. Read More

Pediatr Neurosurg 2021 24;56(2):184-196. Epub 2021 Mar 24.

Department of Medical Oncology, All India Institute of Medical Sciences, New Delhi, India.

Introduction: Spinal atypical teratoid/rhabdoid tumour (AT/RT) is exquisitely rare and constitutes 2% of all AT/RTs.

Case Presentation: A 6-year-old boy presented with low backache for the last 5 months. MRI of the spine showed a 1. Read More

Int J Surg Case Rep 2021 Apr 11;81:105747. Epub 2021 Mar 11.

Spine Center, Sanbo Brain Hospital, Capital Medical University, Beijing, People's Republic of China. Electronic address:

Introduction And Importance: Huge intramedullary tumor is a rare condition. Surgical management of such huge ependymoma is technically challenging. We reported one case of 300 mm long intramedullary spinal cord ependymoma from oblongata to T4, which was satisfactorily en bloc gross total resected and the cervical spine alignment was successfully maintained by laminoplasty. Read More

Clin Spine Surg 2021 03;34(2):E100-E106

Department of Orthopaedic Surgery, Nagoya University Graduate School of Medicine, Tsurumai-cho, Showa-ku, Nagoya.

Study Design: A retrospective study of preoperative and postoperative magnetic resonance imaging (MRI) findings in spinal ependymoma.

Objective: The goal of the study was to examine MRI features, including the syrinx component volume, after surgical resection of spinal ependymoma, and to relate these features to extent of resection and improvement of postoperative neurological status.

Summary Of Background Data: Spinal ependymomas have a variety of MRI findings preoperatively, including a hemorrhage cap sign, gadolinium enhancement, and a spinal tumor cyst. Read More

Cureus 2021 Jan 7;13(1):e12558. Epub 2021 Jan 7.

Anesthesiology, McGovern Medical School, University of Texas Health Science Center, Houston, USA.

Neuraxial anesthesia is preferred over general anesthesia for cesarean delivery when appropriate because the latter is associated with a higher incidence of airway complications and an increased need for neonatal resuscitation. Common complications of neuraxial anesthesia include backache and headache, whereas feared but rare complications include paraplegia, intraspinal hemorrhage, cauda equina syndrome, nerve injury, and epidural hematoma. This case report presents a 40-year-old female with undiagnosed and asymptomatic ependymoma who presented with concerning neurological symptoms after receiving spinal anesthesia for elective cesarean delivery. Read More

BMJ Case Rep 2021 Jan 28;14(1). Epub 2021 Jan 28.

Neurosurgery, University of Puerto Rico Medical Sciences Campus, San Juan, Puerto Rico

This report presents the longest spanning intradural myxopapillary ependymoma consisting of 23 vertebral segments in the literature. An 11-year-old boy presented with right arm pain, mid back pain and progressive paraparesis associated with urinary retention. On MRI, the patient was found to have an intradural lesion extending from C5 to S3. Read More

Neurochirurgie 2021 Nov 21;67(6):632-635. Epub 2021 Jan 21.

Department of Neurosurgery, Kaiser Permanente, Redwood City, CA, United States.

Spinal Cord Ser Cases 2021 01 19;7(1). Epub 2021 Jan 19.

Department of Orthopaedic Surgery, School of Medicine, Keio University, Tokyo, Japan.

Introduction: Of the 23 cases of spinal intradural-extramedullary ependymomas which have been reported to date, 11 were diagnosed as anaplastic. Here we present a very rare case of a thoracic intradural-extramedullary (not intramedullary) anaplastic ependymoma in an adult along with a literature review.

Case Presentation: A 29-year-old man presented with rapidly progressive gait disturbance, a sensory-deficit below the trunk and urination disorders that had begun a few months earlier. Read More

BMJ Case Rep 2020 Dec 17;13(12). Epub 2020 Dec 17.

Medical Oncology, The Queen Elizabeth Hospital, Adelaide, South Australia, Australia.

Myxopapillary ependymoma (MPE) is a rare glial tumour mainly located in the areas of the conus medullaris, cauda equina and filum terminale of the spinal cord. Ectopic MPE tends to behave more aggressively and distant metastases are often seen. Unfortunately, no standard treatment options are established as only small series of treated patients and a few reported cases are available in the literature. Read More

Clin Neurol Neurosurg 2021 01 19;200:106321. Epub 2020 Oct 19.

Department of Neurosurgery, University of Iowa Carver College of Medicine, Iowa City, IA USA. Electronic address:

Objective: The histopathology of intramedullary spinal cord tumors (IMSCT) can be suspected from the MRI features and characteristics. Ultimately, the confirmation of diagnosis requires surgery. This retrospective study addresses MRI features including homogeneity of enhancement, margination, and associated syrinx in intramedullary astrocytomas (IMA) and ependymomas (IME) that assist in diagnosis and predict resectability of these tumors. Read More