Search Our Scientific Publications & Authors

Transl Oncol 2020 Jul 10;13(10):100826. Epub 2020 Jul 10.

AntiCancer, Inc., San Diego, CA, USA; Department of Surgery, University of California, San Diego, CA, USA. Electronic address:

Bone is one of the most frequent metastatic sites in non-small cell lung cancer (NSCLC). Osimertinib, with and without bevacizumab (BV), has been investigated on advanced NSCLC patients. However, the efficacy of those drugs on bone metastasis of NSCLC has not been investigated. Read More

Clin Nucl Med 2020 Jul 8. Epub 2020 Jul 8.

From the Department of Radiology, Louisiana State University Health Sciences Center-Shreveport.

We report a case of a 66-year-old woman with small cell lung cancer (stage IIB, T2N1M0), who received immunotherapy with nivolumab monthly for 2 months and then presented with thyrotoxic symptoms associated with suppressed thyroid-stimulating hormone levels and elevated free thyroid hormone levels, although previous thyrotropin performed 1 month ago was normal. Thyroid uptake and scan demonstrated diffusely decreased uptake in both thyroid lobes. The 4-hour percentage uptake was 0. Read More

Thorac Cancer 2020 Jul 13. Epub 2020 Jul 13.

Department of Oncology, The First Affiliated Hospital of Anhui Medical Universtiy, Hefei, China.

A 53-year-old man diagnosed with disease stage IIIB pulmonary adenocarcinoma underwent chemotherapy and radiotherapy in the first-line setting. After disease progression, he received targeted therapy because of subsequent detection of EGFR exon 19 del mutation. Following an increase in his adrenal metastases, a combination of immunotherapy and antiangiogenic therapy (sintilimab plus bevacizumab) was commenced. Read More

BMC Gastroenterol 2020 Jul 11;20(1):220. Epub 2020 Jul 11.

Department of Surgery, Shizuoka City Shimizu Hospital, 1231 Miyakami, Shimizu-ku, Shizuoka, 424-8636, Japan.

Background: Therapy targeting programmed death-1 or programmed death-1 ligand-1 (PD-1/PD-L1) has been developed for various solid malignant tumors, such as melanoma and non-small-cell lung cancer (NSCLC), but this approach has little effect in the treatment of pancreatic cancer. Pancreatic undifferentiated carcinoma with osteoclast-like giant cells (UCOGC) is a rare pancreatic malignancy having unique morphology and is considered a variant of pancreatic ductal adenocarcinoma (PDAC). Although UCOGC has been reported to have better prognosis than conventional PDAC, the optimal treatment for UCOGC with distant metastases has not been determined. Read More

Ann Palliat Med 2020 Jul 9. Epub 2020 Jul 9.

Department of Radiology, Beijing Friendship Hospital, Capital Medical University, Beijing, China.

Background: The incidence of tumors during pregnancy is 1ntscomprising 0.07-0.1% of all malignant tumors. Read More

Ann Palliat Med 2020 Jun 30. Epub 2020 Jun 30.

Department of Geriatric Oncology, Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School, Nanjing, China.

Leptomeningeal metastasis (LM) is one of the most severe complications of non-small cell lung cancer (NSCLC), and it lacks standard treatment guidelines and is always accompanied by poor prognosis. We report a patient who was definitively diagnosed as LM from NSCLC with a targeted mutation of epidermal growth factor receptor (EGFR) via magnetic resonance imaging (MRI) and positive cerebrospinal fluid (CSF) cytology. Tyrosine kinase inhibitors (TKIs) were implemented but ineffective. Read More

J Thorac Dis 2020 Jun;12(6):3217-3226

Department of Nuclear Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Pulmonary enteric adenocarcinoma (PEAC) is an extremely rare type of non-small cell lung cancer (NSCLC) with a histologic pattern that mimics metastatic colorectal cancer (MCC). The main clinical symptoms in PEAC patients are dyspnoea, coughing, hemoptysis, and chest and back pain. The first article about PEAC appeared in 1991 in the form of a case report. Read More

J Thorac Dis 2020 May;12(5):2482-2488

Department of Radiation Oncology, Rutgers Cancer Institute of New Jersey, Robert Wood Johnson Medical School, Rutgers University, New Brunswick, NJ, USA.

Background: We hypothesized that significant tumor volume reduction (TVR) occurs over the course of stereotactic body radiotherapy (SBRT) for early stage non-small cell lung cancer (NSCLC), and that TVR correlates with clinical outcomes.

Methods: We conducted a retrospective review of patients treated with SBRT for early stage NSCLC across two academic centers. For each patient, we contoured the tumor volume (TV) on cone beam computed tomography (CBCT) images obtained before each treatment fraction. Read More

J Thorac Dis 2020 May;12(5):2082-2087

Department of Thoracic Surgery, Albany Medical Center, Albany, NY, USA.

Background: Accurate staging of lung cancer is paramount for directing treatment. After an internal audit suggested a higher than expected rate of synchronous multiple primary lung cancers (SMPLC), we have sought to evaluate the prevalence of SMPLC at our single, large academic center.

Methods: From January 2019 to September 2019, patients with non-small cell lung cancer who underwent surgical resection were retrospectively reviewed. Read More

Heliyon 2020 Jun 29;6(6):e04319. Epub 2020 Jun 29.

Department of Internal Medicine, Section of Medical Oncology, Dartmouth-Hitchcock Medical Center, 1 Medical Center Dr, Lebanon, NH, 03765, USA.

Background: There are limited data and conflicting guideline recommendations regarding the role of neuroimaging in the pretreatment evaluation of non-small cell lung cancer (NSCLC).

Methods: We performed a retrospective, pragmatic cohort study of patients with NSCLC diagnosed between January 1 and December 31, 2015. Eligible patients were identified from an institutional tumor registry. Read More

Int J Nanomedicine 2020 30;15:4691-4703. Epub 2020 Jun 30.

NHC and CAMS Key Laboratory of Molecular Probe and Targeted Theranostics, Molecular Imaging Research Center (MIRC), Harbin Medical University, Harbin, Heilongjiang, 150028, People's Republic of China.

Purpose: Gd-encapsulated carbonaceous dots (Gd@C-dots) have excellent stability and magnetic properties without free Gd leakage, therefore they can be considered as a safe alternative T1 contrast agent to commonly used Gd complexes. To improve their potential for cancer diagnosis and treatment, affibody-modified Gd@C-dots targeting non-small-cell lung cancer (NSCLC) EGFR-positive tumors with enhanced renal clearance were developed and synthesized.

Materials And Methods: Gd@C-dots were developed and modified with Ac-Cys-Z through EDC/NHS. Read More

J Immunother Cancer 2020 Jul;8(2)

Department of Thoracic Surgery, Tongji University Affiliated Shanghai Pulmonary Hospital, Shanghai, China

Background: Tumor mutational burden (TMB) is a significant predictor of immune checkpoint inhibitors (ICIs) efficacy. This study investigated the correlation between deep learning radiomic biomarker and TMB, including its predictive value for ICIs treatment response in patients with advanced non-small-cell lung cancer (NSCLC).

Methods: CT images from 327 patients with TMB data (TMB median=6. Read More

J Orthop Surg (Hong Kong) 2020 Jan-Apr;28(2):2309499020915989

Department of Orthopedic Surgery, Xuzhou Central Hospital, The Affiliated Xuzhou Hospital of Medical College of Southeast University, Xuzhou, China.

Purpose: Evidence on the incidence, prevalence, and outcomes of bone metastases among patients with systemic malignancy is limited. This study aimed to evaluate it using the Surveillance, Epidemiology, and End Results (SEER) database.

Methods: We collected patients diagnosed with solid malignant tumors deriving outside of the bone, hematologic malignancies, Kaposi sarcoma, lymphoma, and myeloma from the SEER database (from 2010 to 2013). Read More

Bioorg Med Chem 2020 Aug 30;28(15):115577. Epub 2020 May 30.

Department of Nuclear Medicine, Zhongshan Hospital, Fudan University, Shanghai, China; Institute of Nuclear Medicine, Fudan University, Shanghai, China; Shanghai Institute of Medical Imaging, Shanghai, China. Electronic address:

c-MET-positive NSCLC is an important subtype accounting for about 5%~22% of lung cancer. NSCLC patients with activating c-MET are intensively sensitive to c-MET selective receptor tyrosine kinase (RTK) inhibitors, so we aimed to develop a specific PET probe targeting to c-MET-positive NSCLC for potential patients screened by PET/CT. Herein, PET tracer F-radiolabeled crizotinib derivative ([F]FPC) was successfully achieved through a simple one-step F-labeling method. Read More

Bioorg Med Chem Lett 2020 Aug 2;30(16):127257. Epub 2020 Jun 2.

Vanderbilt Center for Molecular Probes, United States; Vanderbilt University, Institute of Imaging Science, United States; Vanderbilt University Medical Center, United States; Department of Radiology, Vanderbilt University Medical Center, United States. Electronic address:

N-[F]fluoroacetylcrizotinib, a fluorine-18 labeled derivative of the first FDA approved tyrosine kinase inhibitor (TKI) for the treatment of Anaplastic lymphoma kinase (ALK)-rearranged non-small cell lung cancer (NSCLC), crizotinib, was successfully synthesized for use in positron emission tomography (PET). Sequential in vitro biological evaluation of fluoracetylcrizotinib and in vivo biodistribution studies of [F]fluoroacetylcrizotinib demonstrated that the biological activity of the parent compound remained unchanged, with potent ALK kinase inhibition and effective tumor growth inhibition. These results show that [F]fluoroacetylcrizotinib has the potential to be a promising PET ligand for use in NSCLC imaging. Read More

J Med Imaging Radiat Oncol 2020 Jul 5. Epub 2020 Jul 5.

Department of Radiation Oncology, Princess Alexandra Hospital, Woolloongabba, Queensland, Australia.

Objectives: Patients with locally advanced non-small-cell lung cancer (LA-NSCLC) develop brain metastases in 25-50% of cases during the course of their disease. Data on the incidence of metastases occurring in the hippocampus/perihippocampal zones are limited. This is important when considering hippocampal-sparing brain radiation (HS-BR), a method that could potentially reduce the neurocognitive impact of such treatment. Read More

Neurooncol Pract 2020 Mar 1;7(2):211-217. Epub 2019 Oct 1.

CHU-Bordeaux, Radiotherapy Department, France.

Background: Advances in intracranial stereotactic radiosurgery (SRS) have led to dramatically reduced planning target volume (PTV) margins. However, tumor growth between planning and treatment may lead to treatment failure. Our purpose was to assess the kinetics of tumor growth before SRS for brain metastases. Read More

Neurosci Lett 2020 Jul 2:135226. Epub 2020 Jul 2.

Department of Radiotherapy, Huai'an First People's Hospital, Huai'an, 223300, Jiangsu, China.

This research aimed to analyze the dynamic changes of postoperative infection and neuron-specific enolase (NSE) levels in serum in non-small cell lung cancer (NSCLC) patients, and to provide assistance for the monitoring and diagnosis of NSCLC patients. 110 NSCLC patients from January 2017 to January 2019 were selected as the research objects. Preoperative Tumor node (TNM) staging was first recorded. Read More

Acad Radiol 2020 Jul 1. Epub 2020 Jul 1.

Department of Radiology, Shanghai Institute of Medical Imaging, Zhongshan Hospital of Fudan University, Fudan University, No 130, Dongan Rd, Xuhui District, Shanghai, 200032, P.R. of China. Electronic address:

Rationale And Objectives: Histological subtypes of lung cancers are critical for clinical treatment decision. In this study, we attempt to use 3D deep learning and radiomics methods to automatically distinguish lung adenocarcinomas (ADC), squamous cell carcinomas (SCC), and small cell lung cancers (SCLC) respectively on Computed Tomography images, and then compare their performance.

Materials And Methods: 920 patients (mean age 61. Read More

Neurologist 2020 Jul;25(4):106-108

Department of Neurology, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, South Korea.

Introduction: Encephalitis with gamma-aminobutyric acid (GABA)-B receptor antibodies (GABA-B receptor encephalitis) is known to have underlying neoplastic condition in half of the cases; however, there could be an additional event that could work as a trigger factor. Here, we report a patient with GABA-B receptor encephalitis associated with small cell lung cancer, which was probably triggered by enterovirus encephalitis.

Case Report: A 53-year-old man was admitted for a seizure, following fever and headache for 3 days. Read More

AJNR Am J Neuroradiol 2020 Jul 2. Epub 2020 Jul 2.

From the Department of Radiation Oncology (A.D., F.Y.M., D.B.S.)

We report a previously undescribed pattern of brain metastases in patients with e-mutated non-small-cell lung cancer treated with tyrosine kinase inhibitors and radiation therapy. These highly distinct lesions appear to spread focally within the leptomeninges, with invasion along the perivascular spaces (FLIP). The survival of patients with FLIP was significantly better compared with patients with classic leptomeningeal disease (median survival, 21 versus 3 months; = . Read More

J Laparoendosc Adv Surg Tech A 2020 Jul 1. Epub 2020 Jul 1.

Department of Surgery, Mount Sinai Medical Center, Comprehensive Cancer Center, Miami Beach, Florida, USA.

Metastatic disease to the pancreas is a rare entity from all malignant pancreatic masses. Its diagnosis is very challenging, but with the introduction of endoscopic ultrasound (EUS)-fine needle aspiration (FNA), now there is a feasible way to make an accurate histopathological and definitive diagnosis. This is a retrospective review of 11 patients with metastasis to the pancreas diagnosed with EUS-FNA in a tertiary referral center over a period of 3 years. Read More

Ochsner J 2020 ;20(2):232-235

Department of Internal Medicine, University of South Dakota Sanford School of Medicine, Sioux Falls, SD.

Adenocarcinoma is the most prevalent type of non-small cell carcinoma of the lungs. Patients with lung adenocarcinoma often present with cough, dyspnea, pain, and weight loss. They can also present with signs and symptoms of brain metastasis because the lungs are one of the most common origins of metastatic brain cancer. Read More

Drug Des Devel Ther 2020 9;14:2263-2274. Epub 2020 Jun 9.

Department of Oncology Radiotherapy, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, People's Republic of China.

Purpose: Lung cancer remains the leading cancer-associated deaths worldwide. Cisplatin (CDDP) was used in combination with curcumin (CUR) for the treatment of non-small cell lung cancer. The aim of this study was to prepare and characterize CDDP prodrug and CUR co-encapsulated layer-by-layer nanoparticles (CDDP-PLGA/CUR LBL NPs) to induce cooperative response, maximize the therapeutic effect, overcome drug resistance, and reduce adverse side effects. Read More

Eur J Radiol 2020 Aug 25;129:109150. Epub 2020 Jun 25.

Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Thoracic Surgery II, Peking University Cancer Hospital & Institute, Beijing, China. Electronic address:

Purpose: Adenocarcinoma (ADC) is the most common histological subtype of lung cancers in non-small cell lung cancer (NSCLC) in which ground glass opacifications (GGOs) found on computed tomography (CT) scans are the most common lesions. However, the presence of a micropapillary or a solid component is identified as an independent predictor of prognosis, suggesting a more extensive resection. The purpose of our study is to explore imaging phenotyping using a method combining radiomics with deep learning (RDL) to predict high-grade patterns within lung ADC. Read More

Can Assoc Radiol J 2020 Jun 30:846537120933837. Epub 2020 Jun 30.

Department of Radiology, Ege University Faculty of Medicine, Bornova, Izmir, Turkey.

Purpose: Our study aimed to investigate the role of histogram analysis derived from apparent diffusion coefficient (ADC) maps in brain metastases (BMs) from lung cancer for differentiating histological subtype.

Methods: A total of 61 BMs (45 non-small cell lung cancer [NSCLC] comprising 32 adenocarcinoma [AC], 13 squamous cell carcinoma [SCC], and 16 small-cell lung cancer [SCLC]) in 50 patients with histopathologically confirmed lung cancer were retrospectively included in this study. Pretreatment cranial diffusion-weighted imaging was performed, and the corresponding ADC maps were generated. Read More

Molecules 2020 Jun 24;25(12). Epub 2020 Jun 24.

Graduate School of Medical Sciences, Kanazawa University, Kakuma-machi, Kanazawa, Ishikawa 920-1192, Japan.

Rociletinib (CO-1686), a 2,4-diaminopyrimidine derivative, is a highly potent tyrosine kinase inhibitor (TKI) that acts on epidermal growth factor receptor (EGFR) with L858R/T790M mutations. We supposed radioiodinated CO-1686 would function as a useful tool for monitoring EGFR L858R/T790M mutations. To aid in patient selection before therapy with EGFR-TKIs, this study aimed to develop a I-labeled derivative of CO-1686, -{3-[(2-{[4-(4-acetylpiperazin-1-yl)-2-methoxyphenyl]amino}-5-(trifluoromethyl)pyrimidine-4-yl] amino}-5-([I]iodophenyl)acrylamide ([I]ICO1686) and evaluate its selectivity toward EGFR L858R/T790M. Read More

Case Rep Oncol 2020 May-Aug;13(2):601-605. Epub 2020 Jun 4.

Department of Thoracic Oncology, Hubei Cancer Hospital, Wuhan, China.

Pulmonary sarcomatoid carcinoma (PSC) is a rare subtype of non-small-cell lung cancer, which is resistant to the conventional chemotherapy and radiotherapy with a poor prognosis. Limited case reports have showed good response to the immunotherapy in PSC patients with high PD-L1 expression generally. Herein, we report a case of rapid recurrence of PSC during postoperative adjuvant chemotherapy in a 62-year-old male ex-smoker. Read More

Dig Dis Sci 2020 Jun 27. Epub 2020 Jun 27.

Division of Gastroenterology, Hepatology, and Endoscopy, Brigham and Women's Hospital, Boston, MA, USA.

Background: Immune checkpoint inhibitors (ICI) have improved outcomes in patients with various malignancies; however, they can cause immune-related hepatitis and enterocolitis. Patients on ICI may also develop upper gastrointestinal symptoms and undergo measurement of gastric emptying.

Aims: Our aim was to review records of patients with gastroparesis following ICI therapy at two medical centers. Read More

Recent Results Cancer Res 2020 ;216:773-794

Department of Radiation Oncology, Klinikum Rechts der Isar, Technical University of Munich (TUM), Ismaninger Straße 22, 81675, Munich, Germany.

Medical imaging plays an imminent role in today's radiation oncology workflow. Predominantly based on semantic image analysis, malignant tumors are diagnosed, staged, and therapy decisions are made. The field of "radiomics" promises to extract complementary, objective information from medical images. Read More

Clin Chim Acta 2020 Jun 24;509:295-303. Epub 2020 Jun 24.

Department of Laboratory Medicine, Zhejiang Provincial People's Hospital, People's Hospital of Hangzhou Medical College, Hangzhou, Zhejiang 310014, China. Electronic address:

Aims: Here, we explored the potential application and selection of neuroendocrine biomarkers in the diagnosis and treatment of small cell lung cancer.

Methods: We retrospectively analyzed 118 patients with small cell lung cancer (SCLC), 166 patients with non-small cell lung cancer (NSCLC), 33 patients with benign lung disease (BLD), and 200 healthy individuals admitted to Zhejiang Provincial People's Hospital between January 1, 2015 and May 31, 2019. All the patients were newly diagnosed with either SCLC, NSCLC, or BLD and previously untreated. Read More

Curr Med Chem 2020 Jun 25. Epub 2020 Jun 25.

Department of Nuclear Medicine, Medical University of Innsbruck, A-6020 Innsbruck. Austria.

A wide variety of radiolabeled peptide analogs for specific targeting of cholecystokinin-2 receptors has been developed in the last decades. Peptide probes based on the natural ligands minigastrin (MG) and cholecystokinin (CCK) have high potential for molecular imaging and targeted radiotherapy of different human tumors, such as medullary thyroid carcinoma (MTC) and small cell lung cancer (SCLC). MG analogs with high persistent uptake in CCK2R expressing tumors have been preferably used for the development of radiolabeled peptide analogs. Read More

Am J Case Rep 2020 Jun 23;21:e922342. Epub 2020 Jun 23.

Department of Hematology, University Hospital of Salamanca, Salamanca, Spain.

BACKGROUND Paraneoplastic cerebellar degeneration (PCD) is a rare condition that can present as an acute or subacute cerebellar syndrome. PCD is most commonly associated with gynecological and breast cancer, small-cell lung cancer, and classical Hodgkin's lymphoma. The symptoms of PCD can arise several months before tumor diagnosis. Read More

Clin Imaging 2020 Jun 15;68:61-67. Epub 2020 Jun 15.

Department of Radiology, Mount Sinai School of Medicine, NY, NY, USA; Phoenix Veterans Affairs Health Care System, Phoenix, AZ, USA.

Objective: Evaluation of sensitivity and specificity of CT and fluorodeoxyglucose-positron emission tomography for pre-surgical staging of mediastinal lymph node metastases (N2/N3) of non-small-cell-lung-cancers ≤30 mm.

Methods: We reviewed a total of 263 patients from a prospective cohort study, who underwent resection including mediastinal lymph nodes, for first primary non-small-cell-lung-cancer ≤30 mm in maximum diameter on pre-surgical CT. Cutoff criteria for short-axis diameter on CT of the largest N2/N3 node of 10, 15, and 20 mm and positron emission uptake of 2. Read More

Ann Nucl Med 2020 Jun 21. Epub 2020 Jun 21.

Department of Nuclear Medicine, Shanghai Pulmonary Hospital, Tongji University School of Medicine, 507 Zhengmin Road, Shanghai, 200433, China.

Objective: Human copper transporter 1 (CTR1) has been proven to be overexpressed in many types of cancer cells, and copper (II)-64 chloride (CuCl) has been used as an effective tracer for positron emission tomography (PET) imaging in tumor-bearing animal models. Thus, this study aimed to investigate the potential application of CuCl in PET imaging of lung cancer through targeting CTR1.

Methods: The expression of CTR1 in a series of lung cancer cell lines was identified by quantitative real-time polymerase chain reaction (Q-PCR), western blot, enzyme-linked immunosorbnent assay (ELISA), and immunofluorescent staining. Read More

Lung Cancer 2020 Jun 2;146:197-208. Epub 2020 Jun 2.

Division of Cancer Sciences, University of Manchester, Manchester, UK.

Radiomics has become a popular image analysis method in the last few years. Its key hypothesis is that medical images harbor biological, prognostic and predictive information that is not revealed upon visual inspection. In contrast to previous work with a priori defined imaging biomarkers, radiomics instead calculates image features at scale and uses statistical methods to identify those most strongly associated to outcome. Read More

Cell Rep 2020 Jun;31(11):107765

Department of Biological Sciences, Florida International University, Miami, FL 33199, USA; Biomolecular Sciences Institute, Florida International University, Miami, FL 33199, USA. Electronic address:

Tumor cell plasticity, including transdifferentiation, is thought to be a key driver of therapy failure, tumor dormancy, and metastatic dissemination. Although melanoma cells have been shown to adopt various phenotypic features in vitro, direct in vivo evidence of metastatic cell plasticity remains sparse. Here, we combine lineage tracing in a spontaneous metastatic mouse model of melanoma, advanced imaging, and single-cell RNA sequencing approaches to search for pathophysiologically relevant melanoma cellular states. Read More

ACS Appl Mater Interfaces 2020 Jul 1. Epub 2020 Jul 1.

Department of Radiation Oncology, Shanghai Proton and Heavy Ion Center, Shanghai 201321, China.

Tumor-associated macrophages (TAMs) were a major component of tumor, which comprised up to 50% of tumor mass, and correlated with poor prognosis in more than 80% of cases. TAMs were resistant to radiotherapy and chemotherapy, and radiation could further activate TAMs to promote tumor progression. Herein, we explored a kind of Bi-based mesoporous upconversion nanophosphor (UCNP) loaded with doxorubicin (UCNP-DOX) to elicit immunogenic tumor cell death and repolarize TAMs to an antitumor M1-like type for strengthening the tumor-specific antitumor immune effects of X-ray radiotherapy. Read More

Cells 2020 Jun 15;9(6). Epub 2020 Jun 15.

The School of Biomedical Sciences, Institute of Health and Biomedical Innovation, Queensland University of Technology, Kelvin Grove, QLD 4035, Australia.

Tumor tissue biopsy is often limited for non-small cell lung cancer (NSCLC) patients and alternative sources of tumoral information are desirable to determine molecular alterations such as anaplastic lymphoma kinase (ALK) rearrangements. Circulating tumor cells (CTCs) are an appealing component of liquid biopsies, which can be sampled serially over the course of treatment. In this study, we enrolled a cohort of ALK-positive (n = 8) and ALK-negative (n = 12) NSCLC patients, enriched for CTCs using spiral microfluidic technology and performed DNA fluorescent in situ hybridization (FISH) for ALK. Read More

Tomography 2020 Jun;6(2):250-260

Department of Computer Science and Engineering, University of South Florida, Tampa, FL.

Image acquisition parameters for computed tomography scans such as slice thickness and field of view may vary depending on tumor size and site. Recent studies have shown that some radiomics features were dependent on voxel size (= pixel size × slice thickness), and with proper normalization, this voxel size dependency could be reduced. Deep features from a convolutional neural network (CNN) have shown great promise in characterizing cancers. Read More

Tomography 2020 Jun;6(2):223-230

Department of Radiology, New York Presbyterian Hospital, Columbia University Medical Center, New York, NY; and.

We investigated the performance of multiple radiomics feature extractors/software on predicting epidermal growth factor receptor mutation status in 228 patients with non-small cell lung cancer from publicly available data sets in The Cancer Imaging Archive. The imaging and clinical data were split into training (n = 105) and validation cohorts (n = 123). Two of the most cited open-source feature extractors, IBEX (1563 features) and Pyradiomics (1319 features), and our in-house software, Columbia Image Feature Extractor (CIFE) (1160 features), were used to extract radiomics features. Read More

Data Brief 2020 Aug 2;31:105781. Epub 2020 Jun 2.

Department of Medicine and Surgery, University of Parma, Medical Oncology Unit, University Hospital of Parma, Via Gramsci 14, 43126, Parma, Italy.

The immune regulation of cancer growth and regression has been underscored by the recent success of immunotherapy. The possibility that immune microenvironmental factors may impact on clinical outcome and treatment response still requires intense investigations. Hereby, supporting data of the research article "Integrated CT Imaging and Tissue Immune Features Disclose a Radio-Immune Signature with High Prognostic Impact on Surgically Resected NSCLC" [1], are presented. Read More

J Clin Imaging Sci 2020 6;10:33. Epub 2020 Jun 6.

Departments of Radiology, University of Missouri, Columbia, Missouri, United States.

Objectives: Over 25% of the high-risk population screened for lung cancer have an abnormal computed tomography (CT) scan. Conventionally, these lesions have been biopsied with CT guidance with a high diagnostic yield. Electromagnetic navigational bronchoscopy (ENB) with transbronchial biopsy has emerged as a technology that improves the diagnostic sensitivity of conventional bronchoscopic biopsy. Read More

Front Neurol 2020 28;11:402. Epub 2020 May 28.

Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY, United States.

Early imaging-based treatment response assessment of brain metastases following stereotactic radiosurgery (SRS) remains challenging. The aim of this study is to determine whether early (within 12 weeks) intratumoral changes in interstitial fluid pressure (IFP) and velocity (IFV) estimated from computational fluid modeling (CFM) using dynamic contrast-enhanced (DCE) MRI can predict long-term outcomes of lung cancer brain metastases (LCBMs) treated with SRS. Pre- and post-treatment T-weighted DCE-MRI data were obtained in 41 patients treated with SRS for intact LCBMs. Read More

Cancer Res 2020 Jun 16. Epub 2020 Jun 16.

Department of Radiology, The University of Texas Southwestern Medical Center

Multispectral optoacoustic tomography (MSOT) is an emerging noninvasive imaging modality that can detect real-time dynamic information about the tumor microenvironment (TME) in humans and animals. Oxygen enhanced (OE)-MSOT can monitor tumor vasculature and oxygenation during disease development or therapy. Here we used MSOT and OE-MSOT to examine in mice the response of human non-small cell lung cancer (NSCLC) xenografts to a new class of anti-tumor drugs, heme-targeting agents heme-sequestering peptide 2 (HSP2) and cyclopamine tartrate (CycT). Read More

Anal Chem 2020 Jul 1. Epub 2020 Jul 1.

Department of Chemistry, Loughborough University, Loughborough, Leicestershire LE11 3TU, U.K.

The use of a low aerosol dispersion ablation chamber within a laser ablation inductively coupled plasma mass spectrometer (LA-ICP-MS) setup allows for high-resolution, high-speed imaging of the distribution of elements within a sample. Here we show how this enhanced capability creates new analytical problems and solutions. We report the distribution of platinum at the cellular level in non-small cell lung cancer (NSCLC) explant models after treatment with clinically relevant doses of cisplatin. Read More

Lancet Oncol 2020 07 12;21(7):914-922. Epub 2020 Jun 12.

Vanderbilt Ingram Cancer Center, Vanderbilt University, Nashville, TN, USA.

Background: Early reports on patients with cancer and COVID-19 have suggested a high mortality rate compared with the general population. Patients with thoracic malignancies are thought to be particularly susceptible to COVID-19 given their older age, smoking habits, and pre-existing cardiopulmonary comorbidities, in addition to cancer treatments. We aimed to study the effect of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection on patients with thoracic malignancies. Read More

Cell Mol Biol (Noisy-le-grand) 2020 Jun 5;66(3):138-142. Epub 2020 Jun 5.

Department of Spine Surgery, Xiangya Hospital, Central South University, Changsha 410008, China.

This study aimed to compare the diagnostic efficacy of MRI and PET/CT in lung cancer of mouse with spinal metastasis. 40 healthy Balb/c nude mice were selected. 0. Read More

J Nephrol 2020 Jun 13. Epub 2020 Jun 13.

Renal Unit, University and Hospital Trust of Verona, Verona, Italy.

The transmission of cancer from a donor organ is a rare event but has important consequences. Aim of this systematic review was to summarize all the published evidence on cancer transmission in kidney recipients. We reviewed published case reports and series describing the outcome of recipients with donor-transmitted cancer until August 2019. Read More

Gene 2020 Jun 10;755:144886. Epub 2020 Jun 10.

Department of Respiratory Physicians, Taixing People's Hospital, Taizhou, Jiangsu, China. Electronic address:

Non-small cell lung cancer (NSCLC) is a common lung cancer with high mortality worldwide. Cisplatin (DDP) resistance is a huge limitation for NSCLC therapy. FGD5 antisense RNA 1 (FGD5-AS1) was recognized as a significant cancer cell regulator. Read More