J Affect Disord 2022 Jun 21. Epub 2022 Jun 21.
Department of Psychiatry, Laboratory of Neurological Diseases & Brain Function, Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan Province, China; Mental Health Research Center, Zigong Mental Health Center, Zigong, Sichuan Province, China; Mental Health Research Center, Zigong Institute of Brain Science, Zigong, Sichuan Province, China; Mental Health Center and Psychiatric Laboratory, State Key Laboratory of Biotherapy, West China Hospital of Sichuan University, Chengdu, Sichuan Province, China. Electronic address:
Background: Wide application of resting-state functional magnetic resonance imaging (fMRI) in psychiatric research has revealed that major depressive disorder (MDD) manifest abnormal neural activities in several brain regions involving key resting state networks. However, inconsistent results have hampered our understanding of the exact neuropathology associated with MDD. Therefore, our aim was to conduct a meta-analysis to identify the consistent vulnerable brain regions of MDD in resting state, and to reveal the potential pathogenesis of MDD. Read More