Search Our Scientific Publications & Authors

Pain Pract 2020 Jul 11. Epub 2020 Jul 11.

Department of Anesthesiology, Emergency Medicine and Multidisciplinary Pain Center, Ziekenhuis Oost-Limburg, Genk, Belgium.

Introduction: Cervical epidural corticosteroid injections are frequently used for the treatment of subacute cervicobrachial pain. This therapy isconsidered safe with the vast majority of the complications being minor and transient.

Case Report: We present a case of a woman in her fifties who suffered from cervicobrachialgia and received 2 cervical epidural corticosteroid infiltrations. Read More

Pediatr Pulmonol 2020 Jul 11. Epub 2020 Jul 11.

Center for Pediatric and Maternal Value, Lucile Packard Children's Hospital - Stanford, Stanford Children's Health.

It was my pleasure to review Imaging in Pediatric Pulmonology 2 Edition. Dr. Robert H. Read More

Physiol Rep 2020 Jul;8(13):e14419

Adelaide Medical School, University of Adelaide, Adelaide, SA, Australia.

Cigarette smoke (CS)-induced emphysema is an important contributor to chronic obstructive pulmonary disease (COPD). We have shown the efficacy of azithromycin in reducing airway inflammation in COPD and in reducing exacerbations in severe asthma; however, the effects of long-term azithromycin on emphysema development have not been shown. We employed live animal imaging to monitor emphysema-like development and the effects of interventional azithromycin treatment in CS-exposed mice. Read More

Hum Brain Mapp 2020 Jul 11. Epub 2020 Jul 11.

Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.

Pioneering studies have shown that individual correlation measures from resting-state functional magnetic resonance imaging studies can identify another scan from that same individual. This method is known as "connectotyping" or functional connectome "fingerprinting." We analyzed a unique dataset of 12-30 years old (N = 140) individuals who had two distinct resting state scans on the same day and again 12-18 months later to assess the sensitivity and specificity of fingerprinting accuracy across different time scales (same day, ~1. Read More

J Eur Acad Dermatol Venereol 2020 Jul 11. Epub 2020 Jul 11.

Department of Dermatology, University Hospital Erlangen, CCC-EMN, Friedrich-Alexander-University Erlangen-Nürnberg (FAU), Erlangen, Germany.

Eruptive skin metastases in melanoma are an uncommon manifestation of rapidly progressive, systemic disease . Type and kinetics of these lesions have not been analyzed before, because of the rarity of the event and technical restrictions of total-body photography. We present the first sequential total-body 3D photography-based analysis by a VECTRA 360WB imaging system of a melanoma patient suffering from disseminated, spreading skin metastases under treatment with immune checkpoint antibodies and subsequent BRAF/MEK inhibition. Read More

J Card Surg 2020 Jul 11. Epub 2020 Jul 11.

Department of Cardiac Surgery, Anthea Hospital, GVM Care & Research, Bari, Italy.

Condensation and water loss from gas output of the cardiopulmonary bypass (CPB) oxygenator has been the study object of several research. However, little is known about the propagation of the condensation formed at the level of oxygenator and how potentially it can contaminate the surrounding environment. We aimed to document the moment of formation of the 'gas steam' derived from the CPB oxygenator during cardiac surgery with thermography imaging. Read More

J Card Surg 2020 Jul 11. Epub 2020 Jul 11.

Department of Cardiothoracic Surgery, Liverpool Heart and Chest Hospital, Liverpool, UK.

Objective: Affecting 1 in 500 individuals; hypertrophic cardiomyopathy is an autosomal dominant cardiovascular disorder which is prevalent throughout the world. Surgical myectomy (SM) and alcohol septal ablation (ASA) are two methods currently used for the management of drug refractory hypertrophic obstructive cardiomyopathy (HOCM). ASA may prove to be a useful, less invasive treatment in patients with HOCM METHODS: Electronic literature search was conducted to identify articles that discussed methods to treat drug refractory HOCM. Read More

Skin Res Technol 2020 Jul 11. Epub 2020 Jul 11.

Department of Radiology, the First Affiliated Hospital of Soochow University, Suzhou, Jiangsu Province, P.R.China.

Background: The extent and depth of facial nonmelanoma skin cancers and the involvement of adjacent structures are critical features for surgical planning, but they are difficult to assess clinically. High-resolution MRI (HR-MRI) with microscopy coil may facilitate detailed evaluation of skin lesions. The authors performed this prospective study to determine the value of high-resolution microscopy coil MRI in the preoperative evaluation of nonmelanoma skin cancer. Read More

J Magn Reson Imaging 2020 Jul 11:e27269. Epub 2020 Jul 11.

Department of Internal Medicine II, Ulm University Medical Centre, Ulm, Germany.

Background: Imaging of the lung by MRI is challenging due to the intrinsic low proton density and rapid T * relaxation. MRI methods providing lung parenchyma and function are in demand.

Purpose: To investigate the feasibility of two-dimensional ultrashort echo-time (2D UTE) imaging for lung function assessment. Read More

Liver Int 2020 Jul 11. Epub 2020 Jul 11.

Fatty Liver Program, Division of Digestive and Liver Diseases, Comprehensive Transplant Program, Cedars-Sinai Medical Center, Los Angeles, California, United States.

Background & Aims: Liver fibrosis assessed by liver biopsy is predictive of clinical liver events in patients with nonalcoholic fatty liver disease (NAFLD). Magnetic resonance elastography (MRE) correlates with liver biopsy in assessing liver fibrosis. However, data assessing the relationship between MRE and clinical liver events are lacking. Read More

Pediatr Blood Cancer 2020 Jul 11:e28538. Epub 2020 Jul 11.

San Vito al Tagliamento, Pordenone, Scientific Institute Eugenio Medea, Italy.

Background: Cerebellar tumor survivors often exhibit neuropsychological deficits that could be related to alterations in cerebro-cerebellar networks. This is a pilot study designed to understand if diffusion tensor imaging (DTI)-based tractography is able to identify possible correlations between cerebellar white matter structure and cognitive outcome in children on long-term follow-up for posterior fossa (PF) tumors who were thoroughly assessed for neuropsychological functioning.

Methods: DTI-based tractography was performed in pediatric patients with PF tumors. Read More

Echocardiography 2020 Jul 11. Epub 2020 Jul 11.

Diagnostic Cardiology, Cardiothoracic Vascular Department, Azienda Ospedaliero-Universitaria Careggi, Florence, Italy.

Papillary fibroelastoma (PF) of the right atrium accounts for 2% of nonvalvular cases, and right appendage (RAA) PF was described only once in literature. We present three cases of RAA PF in patients with unrelated symptoms undergoing 3-dimensional transesophageal echocardiographic examination (3D-TEE) scheduled for conventional indications. Key to diagnosis in routine practice resides in systematic examination of the right atrium and RAA in live 3D-TEE imaging with backward and forward navigation of the real-time pyramidal data. Read More

J Magn Reson Imaging 2020 Jul 11:e27291. Epub 2020 Jul 11.

Graduate School of Health Sciences, Hokkaido University, Sapporo, Japan.

Hum Mutat 2020 Jul 11. Epub 2020 Jul 11.

Brain and Mitochondrial Research Group, Murdoch Children's Research Institute, Royal Children's Hospital, Melbourne, Australia.

Defects in the motor domain of kinesin family member 1A (KIF1A), a neuron-specific ATP-dependent anterograde axonal transporter of synaptic cargo, are well-recognized to cause a spectrum of neurological conditions, commonly known as KIF1A-associated neurological disorders (KAND). Here we report one mutation-negative female with classic Rett syndrome (RTT) harboring a de novo heterozygous novel variant [NP_001230937.1:p. Read More

J Card Surg 2020 Jul 11. Epub 2020 Jul 11.

Department of Cardiology, "Iuliu Haţieganu" University of Medicine and Pharmacy, Cluj-Napoca, Romania.

Giant ascending aortic aneurysms are rare clinical entities and are accompanied by a high annual risk of rupture. We present the imaging, intraoperative, and pathology findings of such a case. Read More

J Card Surg 2020 Jul 11. Epub 2020 Jul 11.

Department of Pediatric Cardiovascular and Thoracic Surgery, St. Christopher's Hospital for Children, Philadelphia, Pennsylvania.

Background: Left innominate vein occlusion is a known complication of pacemaker and central venous catheter placement. For dialysis-dependent patients with an arteriovenous fistula (AVF), this can prevent successful hemodialysis and may require surgical intervention.

Case Report: An 8-month-old male was diagnosed with hemolytic uremic syndrome and became dialysis-dependent at 11 months of age. Read More

Mov Disord 2020 Jul 11. Epub 2020 Jul 11.

Department of Clinical Neurosciences, University of Cambridge, Cambridge, United Kingdom.

Background: Synaptic loss is a prominent and early feature of many neurodegenerative diseases.

Objectives: We tested the hypothesis that synaptic density is reduced in the primary tauopathies of progressive supranuclear palsy (PSP) (Richardson's syndrome) and amyloid-negative corticobasal syndrome (CBS).

Methods: Forty-four participants (15 CBS, 14 PSP, and 15 age-/sex-/education-matched controls) underwent PET with the radioligand [ C]UCB-J, which binds to synaptic vesicle glycoprotein 2A, a marker of synaptic density; participants also had 3 Tesla MRI and clinical and neuropsychological assessment. Read More

Epilepsia 2020 Jul 11. Epub 2020 Jul 11.

Department of Pharmacology, Alberta Diabetes Institute, University of Alberta, Edmonton, Alberta, Canada.

Objective: Voltage-gated potassium channels of the KCNQ (Kv7) family are targeted by a variety of activator compounds with therapeutic potential for treatment of epilepsy. Exploration of this drug class has revealed a variety of effective compounds with diverse mechanisms. In this study, we aimed to clarify functional criteria for categorization of Kv7 activator compounds, and to compare the effects of prototypical drugs in a zebrafish larvae model. Read More

Epilepsia 2020 Jul 11. Epub 2020 Jul 11.

Amsterdam UMC, University of Amsterdam, Department of (Neuro) Pathology, Amsterdam Neuroscience, Amsterdam, the Netherlands.

Objective: Depressive disorders are common among about 50% of the patients with drug-resistant temporal lobe epilepsy (TLE). The underlying etiology remains elusive, but hypothalamus-pituitary-adrenal (HPA) axis activation due to changes in glucocorticoid receptor (GR) protein expression could play an important role. Therefore, we set out to investigate expression of the GR in the hippocampus, an important brain region for HPA axis feedback, of patients with drug-resistant TLE, with and without comorbid depression. Read More

Echocardiography 2020 Jul 11. Epub 2020 Jul 11.

Department of Pediatrics, Division of Pediatric Cardiology, Duke University Medical Center, Durham, NC, USA.

Left-sided unguarded tricuspid valve disease with congenitally corrected transposition of the great arteries (ccTGA) is a rare cardiac malformation, only reported a few times in the literature. Two-dimensional echocardiography (2DE) uses standard views to diagnose tricuspid valve disease. Advanced imaging techniques, such as three-dimensional echocardiography, allow for simultaneous visualization of the tricuspid valve annulus and all leaflets. Read More

J Fish Biol 2020 Jul 11. Epub 2020 Jul 11.

Canadian Rivers Institute, Department of Biology and Faculty of Forestry and Environmental Management, University of New Brunswick, Fredericton, NB, Canada.

Imaging sonars are used around the world for fish population monitoring. The accuracy of the length measurements has been reported in multiple studies for relatively short (< 15 m) ranges and high image resolution. However, imaging sonars are often used at longer ranges (i. Read More

Acta Obstet Gynecol Scand 2020 Jul 11. Epub 2020 Jul 11.

Center for Fetal Care and High-risk Pregnancy, Department of Obstetrics and Gynecology, University Hospital of Chieti, Chieti, Italy.

Introduction: Corpus callosum agenesis (ACC) is frequently diagnosed during fetal life; its prognosis depends also on additional anomalies. The additional value of fetal magnetic resonance imaging (MRI) in fetuses with 'isolated' complete (cACC) and partial (pACC) agenesis of the corpus callosum on ultrasound is still debated.

Material And Methods: We performed a systematic literature review and meta-analysis including fetuses with a prenatal diagnosis of cACC and pACC without associated structural anomalies on ultrasound, undergoing fetal MRI. Read More

Curr Opin Chem Biol 2020 Jul 8;57:95-104. Epub 2020 Jul 8.

Department of Chemistry, University of Illinois at Urbana-Champaign, Urbana, IL, 61801, United States; Department of Biochemistry, University of Illinois at Urbana-Champaign, Urbana, IL, 61801, United States; Carl R. Woese Institute for Genomic Biology, University of Illinois at Urbana-Champaign, Urbana, IL, 61801, United States; DOE Center for Advanced Bioenergy and Bioproducts Innovation, University of Illinois at Urbana-Champaign, Urbana, IL, 61801, United States. Electronic address:

Imaging of species in living organisms with high spatiotemporal resolution is essential for understanding biological processes. While functional nucleic acids (FNAs), such as catalytic nucleic acids and aptamers, have emerged as effective sensors for a wide range of molecules, photocaged control of these FNAs has played a key role in translating them into bioimaging agents with high spatiotemporal control. In this review, we summarize methods and results of photocaged FNAs based on photolabile modifications, photoisomerization, and photothermal activation. Read More

iScience 2020 Jun 23;23(7):101308. Epub 2020 Jun 23.

Department of Neurology, McKnight Brain Institute, and Norman Fixel Institute for Neurological Diseases, University of Florida, Gainesville, FL 32611, USA; Department of Neuroscience, Center for Translational Research in Neurodegenerative Disease, University of Florida, Gainesville, FL 32611, USA; Genetics Institute, University of Florida, Gainesville, FL 32611, USA. Electronic address:

We present here PhotoGal4, a phytochrome B-based optogenetic switch for fine-tuned spatiotemporal control of gene expression in Drosophila explants. This switch integrates the light-dependent interaction between phytochrome B and PIF6 from plants with regulatory elements from the yeast Gal4/UAS system. We found that PhotoGal4 efficiently activates and deactivates gene expression upon red- or far-red-light irradiation, respectively. Read More

Neuroimage Clin 2020 Jul 3;27:102337. Epub 2020 Jul 3.

Umeå Centre for Functional Brain Imaging (UFBI), Umeå University, Umeå, Sweden; Danish Research Centre for Magnetic Resonance, Centre for Functional and Diagnostic Imaging and Research, Copenhagen University Hospital Hvidovre, Denmark; Department of Radiation Sciences, Umeå University, Sweden; Institute of Sports Medicine Copenhagen (ISMC), Copenhagen University Hospital Bispebjerg, Copenhagen, Denmark.

Emerging evidence suggests that mental fatigue is a central component of the cognitive and clinical characteristics of stress-related exhaustion disorder (ED). Yet, the underlying mechanisms of mental fatigue in this patient group are poorly understood. The aim of this study was to investigate cortical and subcortical structural neural correlates of mental fatigue in patients with ED, and to explore the association between mental fatigue and cognitive functioning. Read More

Cardiovasc Pathol 2020 May 23;49:107244. Epub 2020 May 23.

Area of Pathology, Department of Woman and Child Health and Public Health, Fondazione Policlinico Universitario A. Gemelli IRCCS, Istituto di Anatomia Patologica, Università Cattolica Del Sacro Cuore, Rome, Italy.

Cardiac myxoma is a rare benign neoplasm of the heart. Historically myxomas were incidental findings during autopsies, however improved imaging techniques made these diagnosis possible in living patients, making the surgical treatment of these neoplasms achievable. Cardiac myxomas may occur both sporadically and in a familial context, often in the clinico-pathological picture of the Carney complex. Read More

Psychiatry Res Neuroimaging 2020 Jun 27;303:111134. Epub 2020 Jun 27.

Department of Bipolar Disorder, Tianjin Anding Hospital, 13 Liulin Road, Hexi District, Tianjin 300222, China. Electronic address:

Major depressive disorder (MDD) is characterized by heterogeneous clinical performance and neurocognitive impairment. It is important to explore the correlation between global functioning and regional homogeneity (ReHo)/amplitude of low-frequency fluctuation (ALFF) values in MDD patients. 67 first-episode, drug naïve MDD patients and 69 healthy subjects were enrolled in the study. Read More

Oral Oncol 2020 Jul 8;110:104756. Epub 2020 Jul 8.

Department of Radiation Oncology and Proton Therapy Center, Linkou Chang Gung Memorial Hospital and Chang Gung University, Taoyuan, Taiwan; Department of Radiation Oncology, Chang Gung Memorial Hospital at Xiamen, Xiamen, China. Electronic address:

Objectives: To investigate the prognostic value of the relative maximum standardized uptake value (SUV) ratio between neck lymph node and primary tumor (NTR) measured by pretreatment F-FDG PET in patients with nasopharyngeal carcinoma (NPC).

Materials And Methods: We retrospectively reviewed patients with non-disseminated NPC who underwent PET scans before radical intensity-modulated radiotherapy (IMRT). Receiver operating characteristic analysis was performed to identify the optimal cut-off value for NTR. Read More

Transl Oncol 2020 Jul 8;13(10):100828. Epub 2020 Jul 8.

Vanderbilt Center for Molecular Probes, Vanderbilt University Medical Center, 1161 21(st) Avenue South, Medical Center North, R0102, Nashville, TN 37232, United States; Vanderbilt University Institute of Imaging Science, Vanderbilt University Medical Center, 1161 21st Avenue South, Medical Center North, R0102, Nashville, TN 37232, United States; Department of Radiology and Radiological Sciences, Vanderbilt University Medical Center, 1161 21st Avenue South, Medical Center North, Nashville, TN 37232, United States; Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, 2220 Pierce Avenue, Nashville, TN 37232, United States. Electronic address:

Improving response to epidermal growth factor receptor (EGFR)-targeted therapies in patients with advanced wild-type (WT) RAS colorectal cancer (CRC) remains an unmet need. In this preclinical work, we evaluated a new therapeutic combination aimed at enhancing efficacy by targeting cancer cell metabolism in concert with EGFR. We hypothesized that combined blockade of glutamine metabolism and EGFR represents a promising treatment approach by targeting both the "fuel" and "signaling" components that these tumors need to survive. Read More

Transl Oncol 2020 Jul 8;13(10):100822. Epub 2020 Jul 8.

Biology and Biological Engineering, Chalmers University of Technology, Gothenburg, Sweden. Electronic address:

Ionizing radiation (IR) is a common mode of cancer therapy, where DNA damage is the major reason of cell death. Here, we use an assay based on fluorescence imaging of single damaged DNA molecules isolated from radiated lymphocytes, to quantify IR induced DNA damage. The assay uses a cocktail of DNA-repair enzymes that recognizes and excises DNA lesions and then a polymerase and a ligase incorporate fluorescent nucleotides at the damage sites, resulting in a fluorescent "spot" at each site. Read More

J Trace Elem Med Biol 2020 Jul 3;62:126611. Epub 2020 Jul 3.

ISTerre, Université Grenoble Alpes, CS 40700, 38058 Grenoble, France.

Background: Ovarian cancer diagnosis is currently based on imaging and circulating CA-125 concentrations with well-known limits to sensitivity and specificity. New biomarkers are required to complement CA-125 testing to increase effectiveness. Increases in sensitivity of isotopic separation via multi collector inductively coupled plasma-mass spectrometry have recently allowed highly accurate measurement of copper (Cu) isotopic variations. Read More

J Photochem Photobiol B 2020 Apr 30;209:111887. Epub 2020 Apr 30.

Laboratory for functional and metabolic imaging, LIFMET, Swiss Federal Institute of Technology (EPFL), Lausanne, Switzerland.

Delayed fluorescence (DF) is a long-lived luminescence process used in a variety of applications ranging from oxygen sensing in biological tissues to organic Light Emitting Diodes. In common cases, DF results from the de-excitation of the first excited triplet state via the first excited singlet state of the chromophore, which produces a mono-exponential light signal whose amplitude and lifetime give an insight into the probed environment. However, non-linear de-excitation reactions such as triplet-triplet annihilation, which can cause decays to lose their mono-exponential nature, are often neglected. Read More

Clin Imaging 2020 Jul 2;69:45-49. Epub 2020 Jul 2.

Department of Diagnostic Radiology, Mansoura Faculty of Medicine, Mansoura, Egypt.

The Aim Of This Work: The aim of this work was to estimate the role of diffusion-weighted imaging (DWI) in predicting malignant invasion of the nipple-areolar complex (NAC) by underlying breast cancer.

Material And Methods: This prospective study included 70 female patients with breast cancer with a mean age of 45.8 years (range: 28-68). Read More

Clin Imaging 2020 Jul 2;69:37-44. Epub 2020 Jul 2.

Department of Radiology, Keck School of Medicine, University of Southern California (USC), Los Angeles, CA, USA.

Contrast media administration has been associated with complications such as nephropathy, cardiovascular morbidity, and neurovascular events, particularly in patients with renal insufficiency. This association has been questioned in recent studies. This review was performed to summarize the most current evidence on contrast induced nephropathy (CIN), contributing factors, and considerations in patients with renal insufficiency. Read More

Clin Imaging 2020 Jul 1;69:33-36. Epub 2020 Jul 1.

Department of Medical Imaging Center, Nanfang Hospital, Southern Medical University, No. 1838 Guangzhou Avenue North, Guangzhou 510515, Guangdong, People's Republic of China; Quality Control Center of Radiology in Guangdong Province, No. 123 Huifu Road West, Guangzhou 510180, Guangdong, People's Republic of China. Electronic address:

The coronavirus disease 2019 (COVID-19) outbreak, first reported in Wuhan, China, is gradually spreading worldwide. For diagnosis, chest computed tomography is a conventional, noninvasive imaging modality that is very accurate for detection and evaluation of pneumonia and is an important adjunct to real-time reverse transcription polymerase chain reaction diagnosis of the virus. Previous studies have reported typical computed tomography imaging features indicative of COVID-19, such as multifocal ground-glass opacities with or without consolidation. Read More

Clin Imaging 2020 May 30;69:27-32. Epub 2020 May 30.

Department of Radiology, Ningbo First Hospital, Ningbo, Zhejiang 315010, China; Department of Nuclear Medicine, Ningbo First Hospital, Ningbo, Zhejiang 315010, China. Electronic address:

Objective: The purpose of this study was to investigate the chest CT imaging features and clinical outcome of coronavirus disease 2019 (COVID-19) in Ningbo, China.

Methods: In this retrospective study, twenty-eight confirmed and seven highly suspected cases of COVID-19 were enrolled in Ningbo first hospital from January 26, 2020 to March 5, 2020. Cases were confirmed by real-time polymerase chain reaction (RT-PCR). Read More

Clin Imaging 2020 Jun 24;69:17-26. Epub 2020 Jun 24.

Department of Cardiovascular Radiology and Endovascular Interventions, All India Institute of Medical Sciences, New Delhi 110029, India.

Stenotic lesions of the pulmonary arteries can be congenital or acquired. Different etiologies may affect the pulmonary arteries, unilaterally or bilaterally, at different levels. The clinical scenario, age of presentation and the precipitating event may provide clues to the underlying etiology. Read More

Am J Otolaryngol 2020 Jul 3;41(6):102636. Epub 2020 Jul 3.

Chronic Respiratory Disease Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Objective: Olfactory dysfunction in coronavirus disease-2019 (COVID-19) is poorly understood. Thus, mechanistic data are needed to elucidate the pathophysiological drivers of anosmia of COVID-19.

Methods: We performed the current study in patients who presented with anosmia and COVID-19 as documented by the polymerase chain reaction (PCR) assay between April 1st and May 15st, 2020. Read More

Eur J Radiol 2020 Jun 30;130:109157. Epub 2020 Jun 30.

Spitäler Schaffhausen, Radiology and Nuclear Medicine, Geissbergstrasse 81, 8208 Schaffhausen, Switzerland.

Purpose: To compare the diagnostic accuracy of diffusion-weighted magnetic resonance imaging (DW-MRI) and fluorine 18 fluorodeoxyglucose positron emission tomography/computed tomography (F-FDG PET/CT) in detection of residual or recurrent tumors and their local extension in patients with head and neck squamous cell carcinoma after treatment with (chemo) radiotherapy (CRT).

Method: Twenty-five patients (17 men, 8 women, median age 64 years, range 49-79) who underwent surgical salvage for residual or recurrent tumors after CRT were included. The histopathologic analysis after the surgical salvage served as the gold standard. Read More

Addict Behav 2020 Jun 26;110:106523. Epub 2020 Jun 26.

Department of Clinical Psychology and Psychotherapy, University of Bamberg, Bamberg, Germany.

Background: Buying-shopping disorder (BSD) is a severe mental disorder in which individuals lose control over their buying/shopping behavior. It is debated whether BSD shares characteristics with other behavioral addictions. The current study aimed at investigating addiction-related concepts, i. Read More

Ultrasonics 2020 Jun 10;108:106183. Epub 2020 Jun 10.

Department of Applied Mechanics, Indian Institute of Technology Madras, Chennai 600036, India. Electronic address:

A fundamental challenge in non-destructive evaluation using ultrasound is to accurately estimate the thicknesses of different layers or cracks present in the object under examination, which implicitly corresponds to accurately localizing the point-sources of the reflections from the measured signal. Conventional signal processing techniques cannot overcome the axial-resolution limit of the ultrasound imaging system determined by the wavelength of the transmitted pulse. In this paper, starting from the solution to the 1-D wave equation, we show that the ultrasound reflections could be effectively modeled as finite-rate-of-innovation (FRI) signals. Read More

Clin Gastroenterol Hepatol 2020 Jul 8. Epub 2020 Jul 8.

Division of Digestive and Liver Disease, UT Southwestern Medical Center.

The Coronavirus disease 2019 (COVID-19) pandemic is expected to have a long-lasting impact on the approach to care for patients at risk for and with hepatocellular carcinoma (HCC) due to the risks from potential exposure and resource reallocation. The goal of this document is to provide recommendations on HCC surveillance and monitoring, including strategies to limit unnecessary exposure while continuing to provide high-quality care for patients. Publications and guidelines pertaining to the management of HCC during COVID-19 were reviewed for recommendations related to surveillance and monitoring practices, and any available guidance was referenced to support the authors' recommendations when applicable. Read More

Clin Gastroenterol Hepatol 2020 Jul 8. Epub 2020 Jul 8.

Center for Interventional Endoscopy, AdventHealth Orlando, Orlando, FL, USA. Electronic address:

Background & Aims: Given the lack of procedure standardization, findings vary from analyses of pancreatic tissues collected by endoscopic ultrasound-guided fine-needle biopsy. It is not clear which needle and technique yield best specimen for analysis. We compared the specimen quality and accuracy of diagnoses made from samples collected by fine-needle biopsy needles using different collection techniques. Read More

Epilepsy Behav 2020 Jul 8;111:107284. Epub 2020 Jul 8.

Department of Neurology, Vanderbilt University Medical Center, Nashville, TN, United States of America. Electronic address:

Purpose: Lamotrigine (LTG) is one of the most used antiseizure medications (ASMs). Titration is indicated for incomplete seizure control, but toxicity with vertigo, ataxia, and diplopia may ensue. Lamotrigine concentration would be the optimal diagnostic test. Read More

World Neurosurg 2020 Jul 8. Epub 2020 Jul 8.

Department of Neurosurgery, North Bristol NHS Trust, Bristol, UK.

Background: Ectopic intracranial schwannomas (those that do not arise from a named cranial nerve) are rare. They account for fewer than 2% of surgically resected central nervous system schwannomas.

Case Description: We report the case of a 14-year-old boy presenting with a left conductive hearing loss and temporal bone deformity. Read More

World Neurosurg 2020 Jul 8. Epub 2020 Jul 8.

Pediatric Division of Neurosurgery, University of California at San Diego. Electronic address:

Brainstem tumors represent formidable lesions for neurosurgical intervention. They should be approached with a thorough understanding of the anatomy and clear sense of surgical goals. A 14-year-old previously healthy female presented with 2 weeks of nausea, headaches, diplopia, and gait instability. Read More

Neurochem Int 2020 Jul 8:104784. Epub 2020 Jul 8.

Department of Anesthesiology, Cangzhou Central Hospital, Cangzhou, China. Electronic address:

Hemorrhagic shock and resuscitation (HSR) may lead to long-term neurological dysfunction, such as depression and anxiety. Carbon monoxide (CO) has emerged as an excellent neuroprotective agent against caspase-1-associated pyroptosis, following HSR. We evaluated the effects and determined the mechanism through which CO protects against emotional changes in a model of HSR, in rats. Read More

J Am Coll Cardiol 2020 Jul 3. Epub 2020 Jul 3.

Department of Cardiovascular Diseases, Mayo Clinic, Rochester, MN, USA; Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA. Electronic address:

Increases in cardiac troponin (cTn) indicative of myocardial injury are common in patients with COVID-19 and associated with adverse outcomes such as arrhythmias and death. These increases are more likely to occur in those with chronic cardiovascular conditions and in those with severe COVID-19 presentations. The increased inflammatory, prothrombotic, and procoagulant responses following SARS-CoV-2 infection increase the risk for acute nonischemic myocardial injury and acute myocardial infarction, particularly type 2 myocardial infarction because of respiratory failure with hypoxia and hemodynamic instability in critically ill patients. Read More

Biophys J 2020 Jun 27. Epub 2020 Jun 27.

Center for Cell and Genome Science, University of Utah, Salt Lake City, Utah; Department of Physics and Astronomy, University of Utah, Salt Lake City, Utah; Department of Biology, University of Utah, Salt Lake City, Utah. Electronic address:

Immature human immunodeficiency virus (HIV) virions have a lattice of Gag and Gag-Pol proteins anchored to the lumen of their envelope. Using electron microscopy, we demonstrate that HIV virus-like particles (VLPs) assembled by the viral protein Gag and tagged at its C-terminus with the fluorescent protein Dendra2 have the same morphology and size as the VLPs assembled using only HIV Gag. We characterize the photophysical properties of Dendra2 and demonstrate that 60% of Dendra2 molecules can be photoswitched and reliably counted in our interferometric photoactivated localization microscopy (iPALM) setup. Read More