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Clin Kidney J 2019 Apr 20;12(2):269-280. Epub 2018 Jul 20.

Division of Nephrology, Ambroise Paré University Medical Center, APHP, University of Paris Ouest (UVSQ), Boulogne Billancourt/Paris, France.

Chronic kidney disease (CKD) is often associated with a mineral and bone disorder globally described as CKD-Mineral and Bone Disease (MBD), including renal osteodystrophy, the latter ranging from high bone turnover, as in case of secondary hyperparathyroidism (SHPT), to low bone turnover. The present article summarizes the important subjects that were covered during 'The Parathyroid Day in Chronic Kidney Disease' CME course organized in Paris in September 2017. It includes the latest insights on parathyroid gland growth, parathyroid hormone (PTH) synthesis, secretion and regulation by the calcium-sensing receptor, vitamin D receptor and fibroblast growth factor 23 (FGF23)-Klotho axis, as well as on parathyroid glands imaging. Read More

Otolaryngol Head Neck Surg 2019 Apr 9:194599819842106. Epub 2019 Apr 9.

4 Department of Radiology, Naval Medical Center San Diego, San Diego, CA.

Objectives: To describe parathyroid computed tomography angiography (PCTA), determine its accuracy, and, as a secondary objective, calculate its mean radiation dosimetry.

Study Design: Retrospective chart review of patients who underwent parathyroidectomy for primary hyperparathyroidism from 2007 to 2015.

Setting: Single-center tertiary care academic military hospital. Read More

Cureus 2019 Jan 26;11(1):e3966. Epub 2019 Jan 26.

Internal Medicine, Louis Stokes Cleveland VA Medical Center, Cleveland, USA.

Primary hyperparathyroidism is the third most commonly encountered endocrine disorder after diabetes and thyroid diseases. There has been a constant debate between medical and surgical management of the disorder. Guidelines clearly indicate surgical management over medical management in symptomatic patients and asymptomatic patients below 50 years of age. Read More

Proc (Bayl Univ Med Cent) 2018 Oct 24;31(4):534-536. Epub 2018 Sep 24.

Division of Nephrology, Department of Internal Medicine, Baylor University Medical CenterDallasTexas.

Longstanding severe hyperparathyroidism can lead to the formation of "brown tumors," benign but locally aggressive neoplasms. We present the case of a young woman with end-stage renal disease on hemodialysis with uncontrolled secondary hyperparathyroidism. The patient presented with progressive lower extremity weakness and back pain. Read More

Updates Surg 2019 Apr 3. Epub 2019 Apr 3.

Schwarzwald-Baar Klinikum Villingen-Schwenningen, Klinikstrasse 11, Villingen-Schwenningen, 78052, Germany.

Intraoperative verification of parathyroid glands relies on visual identification by the surgeon and, with some time delay, on serum parathormon measurements and frozen section. Fluorescence imaging, however, is an instant on-table method for direct visualization of parathyroid tissue which is known to exhibit increased autofluorescence intensity when exposed to near-infrared light. In this retrospective observational study, we evaluate the clinical use of this method in a series of patients with primary and secondary hyperparathyroidism. Read More

Eur Arch Otorhinolaryngol 2019 May 16;276(5):1509-1516. Epub 2019 Mar 16.

Department of Nuclear Medicine, Assuta Medical Center, Faculty of Medicine, Tel Aviv. Affiliated with Ben Gurion University, Beersheba, Israel.

Purpose: Preoperative localization of a parathyroid adenoma is usually obtained by the combination of ultrasound and scintigraphy with technetium-99m methoxyisobutylisonitrile. We evaluated the role of F18-fluorocholine in neck positron emission tomography/magnetic resonance imaging as a novel tool for localizing parathyroid adenomas.

Methods: Patients with primary hyperparathyroidism were recruited from February 2016 to August 2017 and F18-fluorocholine positron emission tomography/magnetic resonance imaging was performed to localize the parathyroid adenoma prior to surgery. Read More

North Clin Istanb 2018 9;5(4):361-364. Epub 2018 Aug 9.

Department of Radiology, Ondokuz Mayis University Faculty of Medicine, Samsun, Turkey.

Parathyroid glands are endocrine glands that secrete parathyroid hormone (PTH) and regulate calcium-phosphor metabolism. The overexpression of PTH is called hyperparathyroidism (HPT), and is classified as primary, secondary, and tertiary. Primer HPT (PHPT) is the most common cause of parathyroid adenomas (80%-85%). Read More

Medicine (Baltimore) 2019 Mar;98(10):e14809

Department of Orthopedics.

Rationale: Simultaneous spontaneous bilateral quadriceps tendon rupture is a rare orthopedic injury; its initial diagnosis is misdiagnosed in up to 50% of patients with secondary hyperparathyroidism. Early diagnosis and surgical repair are important to achieve an excellent functional outcome.

Patient Concerns: We report a case of simultaneous spontaneous bilateral quadriceps tendon rupture associated with secondary hyperparathyroidism. Read More

J Endocr Soc 2019 Mar 3;3(3):602-606. Epub 2019 Jan 3.

Department of Pediatrics, Kitano Hospital, Tazuke Kofukai Medical Research Institute, Osaka, Japan.

Maternal-fetal transport of calcium (Ca) is important for bone mineralization in fetal development. Insufficient Ca transport causes transient neonatal hyperparathyroidism (TNHP). Transient receptor potential cation channel, subfamily V, member 6 (TRPV6), has been found to play an important role in the active transport of Ca through the placenta. Read More

Am Surg 2019 Feb;85(2):214-218

Primary hyperparathyroidism is the most common cause of hypercalcemia. Follow-up can be resource-intensive and costly. The aim of this study was to determine if there is a subset of patients who can be defined cured earlier than six months. Read More

Osteoporos Int 2019 Jan 31. Epub 2019 Jan 31.

Division of Nuclear Medicine, MedStar Washington Hospital Center, 110 Irving Street, NW, Suite GB1, Washington, DC, 20010, USA.

Tc99m-sestamibi dual-time imaging is a standard tool for localization of adenomas/hyperplasia in hyperparathyroidism. We investigated the degree and causes of localization failure among different types of hyperparathyroidism. Pre-operative parathyroid hormone levels and size of the gland were major determinants of Tc99m-sestamibi positivity; I scan may be helpful in localization failures. Read More

Bone Rep 2019 Jun 10;10:100187. Epub 2018 Dec 10.

Nephrology Center, Department of Rheumatology, Toranomon Hospital, Tokyo, Japan.

We report a 48-year-old Japanese man with a brown tumor of the right distal tibia. At the age of 25 years, hemodialysis was initiated due to nail-patella syndrome. Severe secondary hyperparathyroidism and osteoporosis progressed over time, so parathyroidectomy was performed at age 45. Read More

Diabetol Int 2018 Jul 21;9(3):196-200. Epub 2018 Feb 21.

Department of Endocrinology, Diabetes and Geriatric Medicine, Akita University Graduate School of Medicine, 1-1-1 Hondo, Akita, 010-8543 Japan.

We herein report a case of a 60-year-old female receiving hemodialysis who developed severe hyperinsulinemic hypoglycemia and lost her consciousness. A calcimimetic agent had been administered for the secondary hyperparathyroidism. The calcimimetic agent, mimicking the elevation of the extracellular calcium ion concentration, activates calcium-sensing receptors (CaSR) of the parathyroid cells and inhibits the parathyroid hormone secretions. Read More

BMC Musculoskelet Disord 2018 Dec 22;19(1):451. Epub 2018 Dec 22.

Department of Osteology and Biomechanics, University Medical Center Hamburg-Eppendorf, Lottestraße 59, 22529, Hamburg, Germany.

Background: The aetiology and pathogenesis of primary bone marrow oedema syndrome (BMES) remain unclear. This retrospective cross-sectional study in a large cohort of patients with BMES was performed to characterise the overall skeletal status and turnover in patients with BMES, with the aim of identifying risk factors for this disease.

Methods: Patients who were diagnosed with BMES on the basis of clinical and radiological (magnetic resonance imaging) findings in our outpatient clinic were identified retrospectively. Read More

Clin Nucl Med 2019 Feb;44(2):123-124

We report a case of a 69-year-old woman with primary hyperoxaluria type I, who developed a severe hypercalcemia despite controlled secondary hyperparathyroidism. Bone scintigraphy showed diffuse increased uptake in axial and peripheral skeleton. F-FDG PET/CT showed countless striking hypermetabolic foci, interesting 2 types of lesions (joint calcifications and periosteal resorptions). Read More

Oral Radiol 2018 May 4;34(2):172-178. Epub 2017 Sep 4.

Faculdade de Odontologia, Campus de São José dos Campos, Universidade Estadual Paulista Julio de Mesquita Filho, Avenida Engenheiro Francisco José Longo, No. 777-Bairro: Jardim São Dimas, São Paulo, 12245-000, Brazil.

Objectives: Secondary hyperparathyroidism (SHPT) is a disease that affects patients with chronic kidney disease, and is characterized by mineral disturbance and bone loss, known as renal osteodystrophy. The aim of this study was to assess the validity of using intraoral phosphor storage plates to take radiographs of the middle phalanges to evaluate bone loss resulting from SHPT during follow-up of these patients.

Methods: The sample consisted of 24 patients with chronic kidney disease, 12 with parathyroid hormone (PTH) levels ≥500 pg/ml, and 12 with PTH levels <500 pg/ml, who underwent hemodialysis weekly. Read More

Clin Nucl Med 2018 Dec;43(12):943-945

From the Department of Nuclear Medicine, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang, People's Republic of China.

A 56-year-old woman with secondary hyperparathyroidism was referred for preoperative localization of hyperfunctioning parathyroid lesions. Tc-MIBI dual-phase and SPECT/CT parathyroid scan showed multiple focal activities behind the thyroid and in the anterior mediastinum, diagnosed as parathyroid hyperplasia. However, the histopathological findings proved them to be hyperplastic parathyroid glands and remnant thymic tissue after parathyroidectomy and unnecessary thoracotomy, respectively. Read More

Case Rep Oncol Med 2018 12;2018:1801652. Epub 2018 Sep 12.

Oncology Division, Department of Surgery, Dr. Cipto Mangunkusumo General Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia.

Brown tumor is a bone lesion that arises in the setting of excess osteoclast activity in hyperparathyroidism. It consists of fibrous tissue, woven bone, and supporting vasculature, while contains no matrix. The characteristic of brown-colored lesion is a result of hemosiderin deposition into the osteolytic cysts. Read More

AME Case Rep 2018 15;2:22. Epub 2018 May 15.

Department of General Surgery, Derriford Hospital, Plymouth, PL6 8DH, UK.

Primary hyperparathyroidism secondary to true sporadic synchronous parathyroid cancer (PTCa) and adenoma (PTa) is rare. This is a case of an 80-year-old female admitted with symptomatic hypercalcaemia, raised serum calcium (Ca) of 3.39 mmol/L and raised parathyroid hormone (PTH) of 44. Read More

Ochsner J 2018 ;18(2):170-175

Department of Radiology, Ochsner Clinic Foundation, New Orleans, LA.

Background: Multiple endocrine neoplasia type 1 (MEN1) is a rare, autosomal dominant inherited syndrome caused by mutations in the MEN1 tumor suppressor gene. The diagnosis is defined clinically by the presence of 2 or more primary MEN1 tumors (parathyroid, anterior pituitary, and pancreatic islet). We describe the case of a patient who presented with classic history and imaging findings for MEN1. Read More

BMJ Case Rep 2018 Sep 23;2018. Epub 2018 Sep 23.

Department of Internal Medicine, Okinawa Chubu Hospital, Uruma, Japan.

CA Cancer J Clin 2018 09 21;68(5):377-386. Epub 2018 Sep 21.

Professor, Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX.

Incidentally detected hypercalcemia usually presents in an indolent manner and is most likely caused by primary hyperparathyroidism. In contrast, hypercalcemia in the patient with a history of cancer presents in a wide range of clinical settings and may be severe enough to warrant hospitalization. This form of hypercalcemia is usually secondary to hypercalcemia of malignancy and can be fatal. Read More

Clin Nucl Med 2018 Oct;43(10):766-768

From the Department of Nuclear Medicine, Northwest Clinics, Alkmaar, the Netherlands.

A 27-year-old man, with a history of chronic renal failure due to obstructive uropathy, treated with hemodialysis and awaiting kidney transplantation, presented with tertiary hyperparathyroidism. Despite regulation of phosphate and calcium and treatment with cinacalcet, the serum parathyroid hormone levels remained elevated. The patient was referred for parathyroidectomy, and a F-fluorocholine PET/CT was acquired for preoperative planning. Read More

Indian J Endocrinol Metab 2018 Jul-Aug;22(4):535-541

Department of Nuclear Medicine, AIIMS, New Delhi, India.

To give an overview of the potential clinical utility of 18F-fluorocholine PET/CT (FCH PET/CT) in imaging of parathyroid adenoma. Available studies have provided preliminary results of 18F-FCH PET/CT in primary and secondary hyperparathyroidism. Results of various studies have shown that 18F-FCH is a promising upcoming tracer for the detection of parathyroid adenomas, especially when multiple, or having low size. Read More

Osteoporos Int 2018 Dec 20;29(12):2667-2675. Epub 2018 Aug 20.

Chair of Internal Medicine, Diabetology and Nephrology, Metabolic Bone Diseases Unit, School of Medicine with the Division of Dentistry in Zabrze, Medical University of Silesia in Katowice, Katowice, Poland.

Two methods of skeletal status assessment-quantitative ultrasound (QUS) and densitometry (DXA)-were applied and compared in a group of children with different renal disorders. Skeletal assessments in children with different renal conditions should rather not be based on a single diagnostic tool. Lumbar spine DXA is very effective to reveal disturbances secondary to glucocorticoids, whereas total body DXA and QUS are both better in identification of disturbances related to decreased GFR. Read More

Indian J Endocrinol Metab 2018 May-Jun;22(3):355-361

Division of Epidemiology and Biostatistics, St John's Research Institute, Bengaluru, Karnataka, India.

Background: Primary hyperparathyroidism (PHPT) is a common endocrine disease with a variable clinical presentation. PHPT is usually symptomatic at presentation in majority of the patients, especially in developing countries. As the accessibility to investigations, advanced imaging methods and surgical procedures are improving, the clinical profile of the patients with PHPT has undergone a palpable change compared to the earlier description. Read More

Clin Imaging 2018 Nov - Dec;52:117-122. Epub 2018 Jul 24.

Department of Orthopedic Surgery, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, United States of America.

Solid aneurysmal bone cyst (ABC) is a rare subtype of ABC that most commonly involves the small bones of the hands or feet. We present a case of a solid ABC of the distal humerus in a 52-year-old man with a history of chronic kidney disease and renal cell carcinoma. On imaging with plain radiographs, CT, and MRI, this expansile lucent lesion with solid internal enhancement had an appearance that overlapped with metastasis or brown tumor of hyperparathyroidism. Read More

Pediatr Rheumatol Online J 2018 Jul 27;16(1):49. Epub 2018 Jul 27.

The Lithuanian University of Health Sciences, A. Mickevičiaus g. 9, Kaunas, Lithuania.

Background: Chronic recurrent multifocal osteomyelitis (CRMO) is a rare auto-inflammatory bone disorder that primarily affects young girls, with a mean age of 10 years at onset. Generally, it is a self-limited disease. However, recent data indicate that more than 50% of patients have a chronic persistent disease and about 20% a recurring course of this condition. Read More

Int Urol Nephrol 2018 Oct 20;50(10):1863-1870. Epub 2018 Jul 20.

University Department of Nephrology, Medical Faculty, University of Skopje, Skopje, Macedonia.

Purpose: The complexity of chronic kidney disease-mineral and bone disorder (CKD-MBD) led to many preclinical and clinical trials. The role of sclerostin in renal pathophysiology remained unresolved, and question whether sclerostin is related to cardiovascular (CV) outcome in patients with CKD is still open. Our aim was to evaluate the possible association between serum sclerostin levels and carotid intima-media thickness (CIMT) in CV pathophysiology through various CKD stages. Read More

Metab Brain Dis 2018 10 4;33(5):1641-1648. Epub 2018 Jul 4.

Department of Medical Imaging, First Affiliated Hospital of Xi'an Jiaotong University, No. 277, West Yanta Road, Xi'an, 710061, Shaanxi-Province, People's Republic of China.

Sleep disturbances are common in end-stage renal disease (ESRD) patients. However, the underlying neuropathological mechanisms are largely unclear. Previous studies have revealed the important role of the thalamus in the potential mechanisms of sleep disorders. Read More

Hip Pelvis 2018 Jun 4;30(2):120-124. Epub 2018 Jun 4.

Department of Orthopedic Surgery, Center for Joint Disease, Chonnam National University Hwasun Hospital, Hwasun, Korea.

The causes of osteolytic lesions found in radiological examinations are not quite certain. Therefore, to determine the appropriate treatment method, various approaches and analyzes are required to find the real cause. Hyperparathyroidism is one of the diseases which forms osteolytic bone lesions so-called brown tumor. Read More

BMJ Case Rep 2018 Jun 5;2018. Epub 2018 Jun 5.

Department of Endocrinology, Hospital Curry Cabral, Lisboa, Portugal.

Gitelman syndrome(GS) is a rare autosomal recessive salt-losing tubulopathy of young adults, characterised by hypokalaemia, hypomagnesaemia, hypocalciuria and secondary hyperaldosteronism. Hypercalcaemia due to hypocalciuria in these patients is extremely rare.A 25-year-old healthy woman was referred to the Endocrinology clinic for evaluation of persistent hypokalaemia. Read More

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2017 Sep;31(18):1415-1418

Deparment of Otology and Skull Base Sugery, Eye Ear Nose and Throat Hospital of Fudan University, Hearing Medicine Key Laboratory of the National Health and Family Planning Commission, Shanghai, 200031, China.

To explore the diagnosis and surgical treatment of chondrosarcoma in the jugular foramen (JF).This study lies on the retrospective analysis about 72 patients with secondary hyperparathyroidism who had parathyroid gland resection in our hospital from 2010 to 2017. All of 72 cases are examined by color doppler ultrasound,99mTC-MIBI nuclide imaging and magnetic resonance imaging. Read More

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2017 Sep;31(18):1408-1410

Department of Otolaryngology Head and Neck Surgery, Peking University Civil Aviation School of Clinical Medicine, Civil Aviation General Hospital,Beijing,100123,China.

To investigatethe diagnostic value of three combined imaging studies' preoperative localization for secondary hyperparathyroidism.This study lies on the retrospective analysis about 72 patients with secondary hyperparathyroidism who had parathyroid gland resection in our hospital from 2010 to 2017. All of 72 cases are examined by color doppler ultrasound,99mTC-MIBI nuclide imaging and magnetic resonance imaging. Read More

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2018 Jan;32(2):142-147

Department of Otorhinolaryngology Head and Neck Surgery,the Civil Aviation General Hospital Beijing,100025,China.

To analyze the clinical profile and therapeutic effect of re-operation treatment in uremic patients complicated with persistent secondary hyperparathyroidism(SHPT)after parathyroidectomy with autotransplantation.Twelve persistent SHPT patients who were treated with reoperation of paramyroidectomy(PTX)were enrolled in this study during the period from Jan 2014 to Jul 2017 in our hospital.We evaluated the location of the remaining parathyroid glands by ultrasonography,dual-phase 99 Tcm-sestamibi scintigraphy,CT and MR imaging of the neck before the operation. Read More

Clin Exp Dermatol 2018 Jul 8;43(5):645-647. Epub 2018 May 8.

Department of Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine, Miami, FL, USA.

BMJ Case Rep 2018 Apr 17;2018. Epub 2018 Apr 17.

Endocrinology Department, Instituto Portugues de Oncologia de Lisboa, Francisco Gentil, Lisbon, Portugal.

Biosensors (Basel) 2018 Apr 8;8(2). Epub 2018 Apr 8.

Department of Physics, University of Texas at El Paso, El Paso, TX 79968, USA.

Defining the pathogenesis of renal osteodystrophy (ROD) and its treatment efficacy are difficult, since many factors potentially affect bone quality. In this study, confocal Raman microscopy and parallel statistical analysis were used to identify differences in bone composition between healthy and ROD bone tissues through direct visualization of three main compositional parametric ratios, namely, calcium content, mineral-to-matrix, and carbonate-to-matrix. Besides the substantially lower values found in ROD specimens for these representative ratios, an obvious accumulation of phenylalanine is Raman spectroscopically observed for the first time in ROD samples and reported here. Read More

J Am Vet Med Assoc 2018 Apr;252(8):929-932

Endocrinol Diabetes Metab Case Rep 2018 8;2018. Epub 2018 Mar 8.

Endocrinology Department, Townsville Hospital, Townsville, Queensland, Australia.

Primary hyperparathyroidism (PH) is a common endocrine abnormality and may occur as part of a genetic syndrome. Inactivating mutations of the tumour suppressor gene have been identified as accounting for a large percentage of hyperparathyroidism-jaw tumour syndrome (HPT-JT) cases and to a lesser degree account for familial isolated hyperparathyroidism (FIHP) cases. Reports of whole gene deletions are exceedingly rare. Read More

Medicine (Baltimore) 2018 Feb;97(8):e9889

Department of Nephrology, Shandong University Qilu Hospital, Jinan City, China.

Rationale: Acute kidney injury (AKI) with hyperparathyroidism caused by nitrite was rare, and renal function and parathyroid hormone (PTH) decreased to normal range after therapy.

Patient Concerns: Acute kidney injury was diagnosed in a 40-year-old male with hyperparathyroidism and cyanosis of his hands and both forearms.

Diagnoses: The patient ate some recently pickled vegetables, and he experienced nausea, vomiting and diarrhoea without oliguria or anuria; Additionally, his hands and both forearms had a typical blue ash appearance. Read More

BMC Musculoskelet Disord 2018 02 13;19(1):53. Epub 2018 Feb 13.

Department of Osteology and Biomechanics, University Medical Center Hamburg-Eppendorf, Lottestraße 59, 22529, Hamburg, Germany.

Background: Impaired bone quality is associated with poor outcome of spinal surgery. The aim of the study was to assess the bone mineral status of patients scheduled to undergo spinal surgery and to report frequencies of bone mineral disorders.

Methods: We retrospectively analyzed the bone mineral status of 144 patients requiring spinal surgery including bone mineral density by dual-energy X-ray absorptiometry (DXA) as well as laboratory data with serum levels of 25-hydroxyvitamin D (25-OH-D), parathyroid hormone, calcium, bone specific alkaline phosphate, osteocalcin, and gastrin. Read More

Foot Ankle Surg 2018 Feb 22;24(1):71-75. Epub 2017 Sep 22.

Department of Foot and Hand Surgery, Agaplesion Diakonieklinikum Hamburg, Hohe Weide 17, 20259 Hamburg, Germany.

We report the case of a 35-year-old woman with painful, nontender mass at the right lateral hindfoot. Computed tomography (CT) and magnetic resonance imaging (MRI) indicated the suspect of a chondroid tumour in the cuboid. The tumour was resected en bloc and histology revealed the presence of a periosteal (juxtacortical) chondroma with secondary aneurysmal bone cyst. Read More

BMC Nephrol 2018 02 2;19(1):24. Epub 2018 Feb 2.

Musculoskeletal Disease Center, VA Loma Linda Healthcare System, 11201 Benton Street, Loma Linda, CA, 92357, USA.

Background: Changes in mineral metabolism and bone structure develop early in the course of chronic kidney disease and at end-stage are associated with increased risk of fragility fractures. The disruption of phosphorus homeostasis leads to secondary hyperparathyroidism, a common complication of chronic kidney disease. However, the molecular pathways by which high phosphorus influences bone metabolism in the early stages of the disease are not completely understood. Read More

G Ital Nefrol 2018 Feb;35(1)

SOC Nefrologia e Dialisi Firenze II.

Disorders of calcium-phosphate-parathormone balance, are very important issues in ESRD patients, that may lead to severe complications, as dystrophic calcinosis cutis, a rare disease, caused by calcium salt deposits in cutaneous or subcutaneous tissues and many organs. We present the case of a 47 years old woman, in ESRD due to membranous glomerulopathy, treated by peritoneal dialysis, who, after 7 months of dialysis, developed painful masses on second finger and fifth metacarpus of the right hand. Laboratory and instrumental data showed hyperparathyroidism with a parathyroid mass consistent with adenoma. Read More

Clin Cases Miner Bone Metab 2017 Sep-Dec;14(3):354-358. Epub 2017 Dec 27.

King Faisal Specialist Hospital and Research Centre Riyadh, Saudi Arabia.

Neonatal severe hyperparathyroidism (NSHPT) is a rare autosomal recessive disease. Children present within the first 6 months of life and more commonly in the first few weeks. Common presentation is poor feeding, polyuria, dehydration, lethargy, failure to thrive, hypotonia, gastrointestinal dysmotility, osteopenia and symptoms of respiratory distress due to a poorly developed chest cage. Read More

Nephrology (Carlton) 2018 02;23(2):190-192

Department of Nephrology, Zhejiang Provincial People's Hospital, Hangzhou, China.

Folia Med (Plovdiv) 2017 12;59(4):396-404

Complex Oncology Center, Plovdiv, Bulgaria

Considered rare disease in the past, primary hyperparathyroidism (PHPT) has dramatically increased in incidence over the past thirty years with the introduction of routine calcium measurements; it is now approximately 42 per 100 000 persons. By far, the most common lesion found in patients with PHPT is the solitary parathyroid adenoma, occurring in 85%-90% of patients, while in the rest 10%- 15% primary hyperplasia of the parathyroid glands is present. Currently, the most widely used surgical approach is minimally invasive parathyroidectomy which is associated with less post-surgery complications and shorter operation time. Read More

Am J Otolaryngol 2018 Mar - Apr;39(2):138-141. Epub 2017 Dec 13.

Department of Head and Neck Surgery, RenJi Hospital, Shanghai JiaoTong University, School of Medicine, Shanghai 200001, China. Electronic address:

Objective: To investigate the combined use of a nanocarbon (NC) suspension and low-dose Tc-MIBI for parathyroid localization during surgery in patients with secondary hyperparathyroidism (sHPT).

Methods: Between March 2010 and September 2015, 40 patients with sHPT were enrolled in this study and were randomized to receive either low-dose Tc-MIBI+NC (group I) or low-dose Tc-MIBI (group II). Pre- and post-operative serum levels of intact PTH (iPTH), calcium and phosphorus between groups were compared and the intra-operative radioactive counts of the parathyroid glands were measured. Read More