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Iran J Kidney Dis 2022 May;16(3):203-208

Department of Maxillofacial Radiology, School of Dentistry, Guilan University of Medical Sciences, Rasht, Iran.

Introduction: This study aimed to investigate the relationship between serum levels of PTH and dental and bone changes in the panoramic view of hemodialysis patients.

Methods: Out of 236 patients with end-stage kidney disease (ESKD) who were hospitalized in two hemodialysis centers, 68 ones were selected and concerning their PTH serum levels, they were assigned to case group (PTH > 300 pg/mL) and control group (150 < PTH < 300 pg/mL). Patients in both groups had undergone dialysis for at least 6 months. Read More

Obes Rev 2022 Jun 15:e13488. Epub 2022 Jun 15.

Department of Gastrointestinal Surgery, First Affiliated Hospital of Jinan University, Guangzhou, China.

This study aimed to investigate the prevalence and factors associated with secondary hyperparathyroidism (SHPT) after Roux-en-Y gastric bypass (RYGB). We searched PubMed, EMBASE, and CENTRAL for relevant studies using search terms gastric bypass, RYGB and hyperparathyroidism. Thirty-four cohort studies with 4331 patients were incorporated into the final meta-analysis. Read More

Radiol Clin North Am 2022 Jul;60(4):547-559

Department of Radiology, Manchester Royal Infirmary, Oxford Road, Manchester M13 9WL, UK.

The characteristic radiological appearances of metabolic bone and soft tissue diseases in chronic renal failure are described and illustrated in the context of advancing understanding of the complex metabolic changes that occur in chronic kidney disease and its management. Read More

Steroids 2022 May 26;185:109054. Epub 2022 May 26.

Department of Biochemistry, All India Institute of Medical Sciences (AIIMS) Bhopal, Madhya Pradesh, India.

Vitamin D is required to maintain normal serum calcium and phosphate levels that help normal bone mineralization, nerve conduction, muscle contraction, immune function, cell proliferation, and differentiation. Interventions including vitamin D supplementation may not improve vitamin D deficiency, as various complex genomic actions could contribute to vitamin D deficiency in the Indian population. Thus, we assessed hypovitaminosis D's relationship with vitamin D receptor (VDR) gene polymorphism and evaluated parathyroid hormone (PTH) levels in seemingly healthy adolescent school-going girls. Read More

Surg Endosc 2022 May 24. Epub 2022 May 24.

Endocrine Surgery Department, Virgen del Rocio University Hospital, Avda. Manuel Siurot S/N, 41013, Seville, Spain.

Background: About 4 years ago, we described the pure endoscopic cervical approach to posterior mediastinum parathyroid adenomas, which we called the "prevertebral cervical approach". At that time, we had operated on three patients and did not have enough quality videos to demonstrate this approach. After broadening our experience, we present our results and show this technique through a video. Read More

J Endocr Soc 2022 Jun 7;6(6):bvac071. Epub 2022 May 7.

Division of Endocrinology, Department of Pediatrics, Boston Children's Hospital, Boston, MA 02115, USA.

Primary hyperparathyroidism has been reported in pediatric patients presenting with slipped capital femoral epiphysis (SCFE), but never in patients with ectopic parathyroid adenoma. A 12-year-old boy with obesity and autism spectrum disorder presented with a limp and was found to have bilateral SCFE. Calcium was elevated to 12. Read More

Cureus 2022 Apr 9;14(4):e23985. Epub 2022 Apr 9.

Orthopaedics, University College of Medical Sciences, Delhi, IND.

A 45-year-old man with stage 4 chronic kidney disease (CKD) on controlled dialysis presented with right-sided painful jaw swelling and protruding into the oral cavity for one year. Examination revealed a 3 x 2.5-cm hard, fixed, and tender swelling of the right mandible. Read More

Gerodontology 2022 Jun;39(2):213-217

Director of Oral and Maxillofacial Radiology, Department of Oncology and Diagnostic Sciences, University of Maryland School of Dentistry, Baltimore, MD, USA.

Introduction: Miliary osteoma cutis (MOC) is a cutaneous disorder that develops in response to an ill-defined process or following acne vulgaris. Most cases present incidentally as small radiographic aggregations of normal bone within the cheeks. Infrequently, MOC has been reported with systemic disease, including renal failure. Read More

Int J Endocrinol 2022 8;2022:4558236. Epub 2022 Apr 8.

Division of Endocrinology & Diabetes, and Division of Radiology, University of Pernambuco Medical School, Recife, Brazil.

Normocalcemic primary hyperparathyroidism (NPHPT) is characterized by elevated serum levels of parathyroid hormone (PTH) with persistently normal serum calcium concentrations after excluding secondary causes of hyperparathyroidism. Urolithiasis and/or nephrocalcinosis may occur in hypercalcemic PHPT, but little is known about these complications in NPHPT. . Read More

SAGE Open Med Case Rep 2022 11;10:2050313X221089759. Epub 2022 Apr 11.

Endocrine Unit, Faculty of Medicine, University Technology MARA, Jalan Hospital, Sungai Buloh, Selangor.

A 48-year-old female with long-standing type 2 diabetes mellitus presented with acute onset of bilateral lower limb weakness. She had been previously well and denied any constitutional symptoms. Physical examinations revealed generalized lower limb weakness with bilateral lower limb hypotonia, power of 0 over 5, reduced deep tendon reflexes, and loss of peripheral sensations up to the level of T10. Read More

Nan Fang Yi Ke Da Xue Xue Bao 2022 Feb;42(2):238-243

Department of Breast Thyroid Surgery, Third Xiangya Hospital of Central South University, Changsha 410013, China.

Objective: To establish an cell model of hyperparathyroidism by isolation, culture, and identification of parathyroid cells from patients with secondary hyperparathyroidism (SHPT).

Methods: The parathyroid gland tissues obtained from 10 patients with SHPT were dissociated by collagenase digestion for primary culture of the parathyroid cells. Morphological changes and growth characteristics of the cells were assessed by microscopic imaging and cell counting. Read More

Korean J Intern Med 2022 05 29;37(3):695-696. Epub 2022 Mar 29.

Faculty of Medicine, School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan.

Ophthalmology 2022 04;129(4):413

Department of Ophthalmology, University of California, San Francisco, San Francisco, California.

Int J Surg Case Rep 2022 Mar 26;92:106874. Epub 2022 Feb 26.

Metrocity Hospital, Pokhara, Nepal.

Introduction And Importance: Parathyroid carcinoma is an extremely rare endocrine neoplasm. Most of the patients present with severe hyperparathyroidism with altered serum calcium levels.

Case Presentation: We describe a patient who presented with a neck mass and secondary hyperparathyroidism Ultrasound (USG) suggested a tumor located near the lower pole of the thyroid gland. Read More

Int J Hyperthermia 2022 ;39(1):466-474

Department of Ultrasound, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.

Background: Hyperparathyroidism (HPT) is classified into primary HPT (PHPT), secondary HPT (SHPT), tertiary HPT (THPT), and pseudohyperparathyroidism. Parathyroid surgery is generally reserved for patients with symptomatic PHPT and asymptomatic patients who meet the surgical guideline criteria. However, the risk of complications and mortality after parathyroid gland surgery increases with increasing patient age. Read More

Transplantation 2022 05 8;106(5):e251-e261. Epub 2022 Mar 8.

Nephrology Department, Hospital Curry Cabral, Centro Hospitalar Universitário Lisboa Central, Lisbon, Portugal.

Background: Posttransplant mineral and bone diseases are causes of fractures, and their association with cardiovascular events is being studied.

Methods: We analyzed the evolution of biochemical, histological, and imaging parameters pre- and 1 y post-renal transplantation in 69 patients and correlated mineral and bone findings with coronary calcifications. At inclusion and after 12 mo, clinical data and echocardiographic findings were recorded, and laboratory evaluations, radiography of the pelvis and hands, and bone biopsy were performed. Read More

Endocrinol Diabetes Metab Case Rep 2022 Mar 1;2022. Epub 2022 Mar 1.

Department of Endocrinology ASO/EASO COM, King 's College Hospital NHS Foundation Trust, Denmark Hill, London, UK.

Summary: A 49-year-old teacher presented to his general physician with lethargy and lower limb weakness. He had noticed polydipsia, polyuria, and had experienced weight loss, albeit with an increase in central adiposity. He had no concomitant illnesses and took no regular medications. Read More

Cureus 2022 Jan 14;14(1):e21233. Epub 2022 Jan 14.

Internal Medicine, Dow University of Health Sciences, Karachi, PAK.

In the following report, we document a case of gastroesophageal reflux disease (GERD) emerging from a peculiar etiology. A 20-year-old male presented to the out-patient department (OPD) of ear, nose & throat (ENT) of Dow University Hospital in Karachi, Pakistan, by referral from remote hospitals with a complaint of stomach upset. Upon a detailed historical assessment of the patient, the picture of a convoluted path to diagnosis emerged. Read More

Q J Nucl Med Mol Imaging 2022 Jun 15;66(2):93-103. Epub 2022 Feb 15.

EANM Dosimetry Committee.

Parathyroid imaging is essential for the detection and localization of hyperfunctioning parathyroid tissue in patients with primary hyperparathyroidism (pHPT). Surgical treatment of pHPT mainly consists of minimally invasive parathyroidectomy (MIP), as a single adenoma represents the most common cause of this endocrine disorder. Successful surgery requires an experienced surgeon and relies on the correct preoperative detection and localization of hyperfunctioning parathyroid glands. Read More

Ren Fail 2022 Dec;44(1):146-154

Department of Medical Ultrasonics, The First Affiliated Hospital, Institute of Diagnostic and Interventional Ultrasound, Sun Yat-Sen University, Guangzhou, China.

Objectives: To analyze conventional ultrasound (CUS) and contrast-enhanced ultrasound (CEUS) features in patients with secondary hyperparathyroidism (SHPT) and to evaluate the clinical-ultrasonographic feature based model for predicting the severity of SHPT.

Methods: From February 2016 to March 2021, a total of 59 patients (age 51.3 ± 11. Read More

JBJS Rev 2022 02 7;10(2). Epub 2022 Feb 7.

Department of Orthopaedic Surgery, Tulane University School of Medicine, New Orleans, Louisiana.

»: The incidence of quadriceps tendon rupture is estimated to be 1.37 cases per 100,000 people/year, with a predilection for these injuries in patients who are ≥40 years of age.

»: Quadriceps tendon ruptures are more likely to occur in the presence of preexisting comorbidities such as rheumatoid arthritis, systemic lupus erythematosus, gout, chronic kidney disease, secondary hyperparathyroidism, diabetes mellitus, and peripheral vascular disease. Read More

AACE Clin Case Rep 2022 Jan-Feb;8(1):37-40. Epub 2021 Aug 3.

Section of Endocrinology, Department of Medicine, Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire.

Background: We report a case of normocalcemic primary hyperparathyroidism, a diagnosis prompted by radiographic "salt and pepper" calvarial lesions, typically described in hypercalcemic primary hyperparathyroidism or secondary hyperparathyroidism.

Case Report: A 60-year-old woman noticed indentations of her scalp and presented to her primary care provider. Radiography of the calvarium demonstrated granular "salt and pepper" lesions, prompting investigation. Read More

Bone 2022 04 24;157:116340. Epub 2022 Jan 24.

Department of Anatomy, Cell Biology & Physiology, Indiana University School of Medicine, Indianapolis, IN, United States; Department of Medicine, Division of Nephrology, Indiana University School of Medicine, Indianapolis, IN, United States; Roudebush Veterans Administration Medical Center, Indianapolis, IN, United States. Electronic address:

Purpose: Chronic kidney disease (CKD) leads to increased bone fragility and risk of fracture. Cortical deteriorations, including cortical porosity, are key factors in fracture susceptibility in CKD. Since secondary hyperparathyroidism is common in CKD individuals and contributes to cortical deterioration, we hypothesized that reducing parathyroid hormone (PTH) may modulate CKD-induced cortical porosity. Read More

Radiol Case Rep 2022 Mar 16;17(3):553-557. Epub 2021 Dec 16.

Department of Radiology, College of Medicine, Qassim University, Buraidah, 6655-51452, Saudi Arabia.

Skeletal changes are a common complication in patients with chronic kidney disease and traditionally labelled as renal osteodystrophy. Uremic leontiasis ossea is a rare and severe form of renal osteodystrophy with characteristic overgrowth of the craniofacial bones. Imaging, in particular computed tomography, is valuable for the diagnosis and management of such rare condition. Read More

Adv Exp Med Biol 2022 ;1374:73-79

Department of Surgery, Fourth Military Teaching Hospital, Wrocław, Poland.

Primary hyperparathyroidism (PHPT) secondary to parathyroid gland adenoma is mildly symptomatic and thus often incidentally diagnosed. In this report, we present a case of a 46-year-old man who was treated for hypertension and other nonspecific complaints. An elevated level of blood calcium led to the suspicion of parathyroid adenoma. Read More

Physiol Res 2021 11;70(Suppl 1):S3-S11

5th department of Internal Medicine, Comenius University Faculty of Medicine, University Hospital Bratislava, Bratislava, Slovakia.

Parathyroid hormone (PTH) increases the release of serum calcium through osteoclasts, which leads to bone resorption. Primary, PTH stimulates osteoblasts leading to increase RANKL (receptor activator for nuclear factor kappa-B ligand) expression and thus differentiation of osteoclasts. In kidneys, PTH increases calcium and decrease phosphate reabsorption. Read More

Semin Nephrol 2021 09;41(5):439-445

Department of Pediatrics, University of California San Francisco, San Francisco, CA.

Chronic kidney disease (CKD) mineral bone disorder has long-term effects on skeletal integrity and growth. Abnormalities in serum markers of mineral metabolism are evident early in pediatric CKD. Bone deformities, poor linear growth, and high rates of fractures are common in children with CKD. Read More

J Bras Nefrol 2021;43(4 Suppl 1):621-627. Epub 2021 Dec 3.

Universidade de São Paulo, Pathophysiology Laboratory (LIM-16), Hospital das Clínicas da Faculdade de Medicina da USP, São Paulo, SP, Brazil.

Bone Rep 2021 Dec 9;15:101142. Epub 2021 Oct 9.

Department of Clinical Chemistry, St. Vincent's University Hospital, Dublin, Ireland.

Tumor-induced osteomalacia (TIO) is an ultrarare disorder that is caused by renal phosphate wasting due to uncontrolled tumoral production of fibroblast growth factor 23 (FGF23) from phosphaturic mesenchymal tumors. Surgical removal of the tumor is curative. There is limited information on the biochemical changes in mineral metabolism and bone remodeling activity after surgery, but it is reported that surgery is followed by a hungry bone syndrome (HBS) with hypocalcemia and secondary hyperparathyroidism. Read More

Cureus 2021 Oct 31;13(10):e19155. Epub 2021 Oct 31.

Pediatric Surgery, King Abdulaziz Medical City, Jeddah, SAU.

Abdominal pain is a common symptom in surgical practice. Around 11%-45% of pediatric population present with abdominal pain. In 29%-87. Read More