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Osteoporos Int 2019 Jan 31. Epub 2019 Jan 31.

Division of Nuclear Medicine, MedStar Washington Hospital Center, 110 Irving Street, NW, Suite GB1, Washington, DC, 20010, USA.

Tc99m-sestamibi dual-time imaging is a standard tool for localization of adenomas/hyperplasia in hyperparathyroidism. We investigated the degree and causes of localization failure among different types of hyperparathyroidism. Pre-operative parathyroid hormone levels and size of the gland were major determinants of Tc99m-sestamibi positivity; I scan may be helpful in localization failures. Read More

Bone Rep 2019 Jun 10;10:100187. Epub 2018 Dec 10.

Nephrology Center, Department of Rheumatology, Toranomon Hospital, Tokyo, Japan.

We report a 48-year-old Japanese man with a brown tumor of the right distal tibia. At the age of 25 years, hemodialysis was initiated due to nail-patella syndrome. Severe secondary hyperparathyroidism and osteoporosis progressed over time, so parathyroidectomy was performed at age 45. Read More

Diabetol Int 2018 Jul 21;9(3):196-200. Epub 2018 Feb 21.

Department of Endocrinology, Diabetes and Geriatric Medicine, Akita University Graduate School of Medicine, 1-1-1 Hondo, Akita, 010-8543 Japan.

We herein report a case of a 60-year-old female receiving hemodialysis who developed severe hyperinsulinemic hypoglycemia and lost her consciousness. A calcimimetic agent had been administered for the secondary hyperparathyroidism. The calcimimetic agent, mimicking the elevation of the extracellular calcium ion concentration, activates calcium-sensing receptors (CaSR) of the parathyroid cells and inhibits the parathyroid hormone secretions. Read More

BMC Musculoskelet Disord 2018 Dec 22;19(1):451. Epub 2018 Dec 22.

Department of Osteology and Biomechanics, University Medical Center Hamburg-Eppendorf, Lottestraße 59, 22529, Hamburg, Germany.

Background: The aetiology and pathogenesis of primary bone marrow oedema syndrome (BMES) remain unclear. This retrospective cross-sectional study in a large cohort of patients with BMES was performed to characterise the overall skeletal status and turnover in patients with BMES, with the aim of identifying risk factors for this disease.

Methods: Patients who were diagnosed with BMES on the basis of clinical and radiological (magnetic resonance imaging) findings in our outpatient clinic were identified retrospectively. Read More

Clin Nucl Med 2019 Feb;44(2):123-124

We report a case of a 69-year-old woman with primary hyperoxaluria type I, who developed a severe hypercalcemia despite controlled secondary hyperparathyroidism. Bone scintigraphy showed diffuse increased uptake in axial and peripheral skeleton. F-FDG PET/CT showed countless striking hypermetabolic foci, interesting 2 types of lesions (joint calcifications and periosteal resorptions). Read More

Oral Radiol 2018 May 4;34(2):172-178. Epub 2017 Sep 4.

Faculdade de Odontologia, Campus de São José dos Campos, Universidade Estadual Paulista Julio de Mesquita Filho, Avenida Engenheiro Francisco José Longo, No. 777-Bairro: Jardim São Dimas, São Paulo, 12245-000, Brazil.

Objectives: Secondary hyperparathyroidism (SHPT) is a disease that affects patients with chronic kidney disease, and is characterized by mineral disturbance and bone loss, known as renal osteodystrophy. The aim of this study was to assess the validity of using intraoral phosphor storage plates to take radiographs of the middle phalanges to evaluate bone loss resulting from SHPT during follow-up of these patients.

Methods: The sample consisted of 24 patients with chronic kidney disease, 12 with parathyroid hormone (PTH) levels ≥500 pg/ml, and 12 with PTH levels <500 pg/ml, who underwent hemodialysis weekly. Read More

Clin Nucl Med 2018 Dec;43(12):943-945

From the Department of Nuclear Medicine, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang, People's Republic of China.

A 56-year-old woman with secondary hyperparathyroidism was referred for preoperative localization of hyperfunctioning parathyroid lesions. Tc-MIBI dual-phase and SPECT/CT parathyroid scan showed multiple focal activities behind the thyroid and in the anterior mediastinum, diagnosed as parathyroid hyperplasia. However, the histopathological findings proved them to be hyperplastic parathyroid glands and remnant thymic tissue after parathyroidectomy and unnecessary thoracotomy, respectively. Read More

Case Rep Oncol Med 2018 12;2018:1801652. Epub 2018 Sep 12.

Oncology Division, Department of Surgery, Dr. Cipto Mangunkusumo General Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia.

Brown tumor is a bone lesion that arises in the setting of excess osteoclast activity in hyperparathyroidism. It consists of fibrous tissue, woven bone, and supporting vasculature, while contains no matrix. The characteristic of brown-colored lesion is a result of hemosiderin deposition into the osteolytic cysts. Read More

AME Case Rep 2018 15;2:22. Epub 2018 May 15.

Department of General Surgery, Derriford Hospital, Plymouth, PL6 8DH, UK.

Primary hyperparathyroidism secondary to true sporadic synchronous parathyroid cancer (PTCa) and adenoma (PTa) is rare. This is a case of an 80-year-old female admitted with symptomatic hypercalcaemia, raised serum calcium (Ca) of 3.39 mmol/L and raised parathyroid hormone (PTH) of 44. Read More

Ochsner J 2018 ;18(2):170-175

Department of Radiology, Ochsner Clinic Foundation, New Orleans, LA.

Background: Multiple endocrine neoplasia type 1 (MEN1) is a rare, autosomal dominant inherited syndrome caused by mutations in the MEN1 tumor suppressor gene. The diagnosis is defined clinically by the presence of 2 or more primary MEN1 tumors (parathyroid, anterior pituitary, and pancreatic islet). We describe the case of a patient who presented with classic history and imaging findings for MEN1. Read More

BMJ Case Rep 2018 Sep 23;2018. Epub 2018 Sep 23.

Department of Internal Medicine, Okinawa Chubu Hospital, Uruma, Japan.

CA Cancer J Clin 2018 Sep 21;68(5):377-386. Epub 2018 Sep 21.

Professor, Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX.

Incidentally detected hypercalcemia usually presents in an indolent manner and is most likely caused by primary hyperparathyroidism. In contrast, hypercalcemia in the patient with a history of cancer presents in a wide range of clinical settings and may be severe enough to warrant hospitalization. This form of hypercalcemia is usually secondary to hypercalcemia of malignancy and can be fatal. Read More

Clin Nucl Med 2018 Oct;43(10):766-768

From the Department of Nuclear Medicine, Northwest Clinics, Alkmaar, the Netherlands.

A 27-year-old man, with a history of chronic renal failure due to obstructive uropathy, treated with hemodialysis and awaiting kidney transplantation, presented with tertiary hyperparathyroidism. Despite regulation of phosphate and calcium and treatment with cinacalcet, the serum parathyroid hormone levels remained elevated. The patient was referred for parathyroidectomy, and a F-fluorocholine PET/CT was acquired for preoperative planning. Read More

Indian J Endocrinol Metab 2018 Jul-Aug;22(4):535-541

Department of Nuclear Medicine, AIIMS, New Delhi, India.

To give an overview of the potential clinical utility of 18F-fluorocholine PET/CT (FCH PET/CT) in imaging of parathyroid adenoma. Available studies have provided preliminary results of 18F-FCH PET/CT in primary and secondary hyperparathyroidism. Results of various studies have shown that 18F-FCH is a promising upcoming tracer for the detection of parathyroid adenomas, especially when multiple, or having low size. Read More

Indian J Endocrinol Metab 2018 May-Jun;22(3):355-361

Division of Epidemiology and Biostatistics, St John's Research Institute, Bengaluru, Karnataka, India.

Background: Primary hyperparathyroidism (PHPT) is a common endocrine disease with a variable clinical presentation. PHPT is usually symptomatic at presentation in majority of the patients, especially in developing countries. As the accessibility to investigations, advanced imaging methods and surgical procedures are improving, the clinical profile of the patients with PHPT has undergone a palpable change compared to the earlier description. Read More

Clin Imaging 2018 Nov - Dec;52:117-122. Epub 2018 Jul 24.

Department of Orthopedic Surgery, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, United States of America.

Solid aneurysmal bone cyst (ABC) is a rare subtype of ABC that most commonly involves the small bones of the hands or feet. We present a case of a solid ABC of the distal humerus in a 52-year-old man with a history of chronic kidney disease and renal cell carcinoma. On imaging with plain radiographs, CT, and MRI, this expansile lucent lesion with solid internal enhancement had an appearance that overlapped with metastasis or brown tumor of hyperparathyroidism. Read More

Pediatr Rheumatol Online J 2018 Jul 27;16(1):49. Epub 2018 Jul 27.

The Lithuanian University of Health Sciences, A. Mickevičiaus g. 9, Kaunas, Lithuania.

Background: Chronic recurrent multifocal osteomyelitis (CRMO) is a rare auto-inflammatory bone disorder that primarily affects young girls, with a mean age of 10 years at onset. Generally, it is a self-limited disease. However, recent data indicate that more than 50% of patients have a chronic persistent disease and about 20% a recurring course of this condition. Read More

Int Urol Nephrol 2018 Oct 20;50(10):1863-1870. Epub 2018 Jul 20.

University Department of Nephrology, Medical Faculty, University of Skopje, Skopje, Macedonia.

Purpose: The complexity of chronic kidney disease-mineral and bone disorder (CKD-MBD) led to many preclinical and clinical trials. The role of sclerostin in renal pathophysiology remained unresolved, and question whether sclerostin is related to cardiovascular (CV) outcome in patients with CKD is still open. Our aim was to evaluate the possible association between serum sclerostin levels and carotid intima-media thickness (CIMT) in CV pathophysiology through various CKD stages. Read More

Metab Brain Dis 2018 10 4;33(5):1641-1648. Epub 2018 Jul 4.

Department of Medical Imaging, First Affiliated Hospital of Xi'an Jiaotong University, No. 277, West Yanta Road, Xi'an, 710061, Shaanxi-Province, People's Republic of China.

Sleep disturbances are common in end-stage renal disease (ESRD) patients. However, the underlying neuropathological mechanisms are largely unclear. Previous studies have revealed the important role of the thalamus in the potential mechanisms of sleep disorders. Read More

Hip Pelvis 2018 Jun 4;30(2):120-124. Epub 2018 Jun 4.

Department of Orthopedic Surgery, Center for Joint Disease, Chonnam National University Hwasun Hospital, Hwasun, Korea.

The causes of osteolytic lesions found in radiological examinations are not quite certain. Therefore, to determine the appropriate treatment method, various approaches and analyzes are required to find the real cause. Hyperparathyroidism is one of the diseases which forms osteolytic bone lesions so-called brown tumor. Read More

BMJ Case Rep 2018 Jun 5;2018. Epub 2018 Jun 5.

Department of Endocrinology, Hospital Curry Cabral, Lisboa, Portugal.

Gitelman syndrome(GS) is a rare autosomal recessive salt-losing tubulopathy of young adults, characterised by hypokalaemia, hypomagnesaemia, hypocalciuria and secondary hyperaldosteronism. Hypercalcaemia due to hypocalciuria in these patients is extremely rare.A 25-year-old healthy woman was referred to the Endocrinology clinic for evaluation of persistent hypokalaemia. Read More

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2017 Sep;31(18):1415-1418

Deparment of Otology and Skull Base Sugery, Eye Ear Nose and Throat Hospital of Fudan University, Hearing Medicine Key Laboratory of the National Health and Family Planning Commission, Shanghai, 200031, China.

To explore the diagnosis and surgical treatment of chondrosarcoma in the jugular foramen (JF).This study lies on the retrospective analysis about 72 patients with secondary hyperparathyroidism who had parathyroid gland resection in our hospital from 2010 to 2017. All of 72 cases are examined by color doppler ultrasound,99mTC-MIBI nuclide imaging and magnetic resonance imaging. Read More

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2017 Sep;31(18):1408-1410

Department of Otolaryngology Head and Neck Surgery, Peking University Civil Aviation School of Clinical Medicine, Civil Aviation General Hospital,Beijing,100123,China.

To investigatethe diagnostic value of three combined imaging studies' preoperative localization for secondary hyperparathyroidism.This study lies on the retrospective analysis about 72 patients with secondary hyperparathyroidism who had parathyroid gland resection in our hospital from 2010 to 2017. All of 72 cases are examined by color doppler ultrasound,99mTC-MIBI nuclide imaging and magnetic resonance imaging. Read More

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2018 Jan;32(2):142-147

Department of Otorhinolaryngology Head and Neck Surgery,the Civil Aviation General Hospital Beijing,100025,China.

To analyze the clinical profile and therapeutic effect of re-operation treatment in uremic patients complicated with persistent secondary hyperparathyroidism(SHPT)after parathyroidectomy with autotransplantation.Twelve persistent SHPT patients who were treated with reoperation of paramyroidectomy(PTX)were enrolled in this study during the period from Jan 2014 to Jul 2017 in our hospital.We evaluated the location of the remaining parathyroid glands by ultrasonography,dual-phase 99 Tcm-sestamibi scintigraphy,CT and MR imaging of the neck before the operation. Read More

Clin Exp Dermatol 2018 Jul 8;43(5):645-647. Epub 2018 May 8.

Department of Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine, Miami, FL, USA.

BMJ Case Rep 2018 Apr 17;2018. Epub 2018 Apr 17.

Endocrinology Department, Instituto Portugues de Oncologia de Lisboa, Francisco Gentil, Lisbon, Portugal.

Biosensors (Basel) 2018 Apr 8;8(2). Epub 2018 Apr 8.

Department of Physics, University of Texas at El Paso, El Paso, TX 79968, USA.

Defining the pathogenesis of renal osteodystrophy (ROD) and its treatment efficacy are difficult, since many factors potentially affect bone quality. In this study, confocal Raman microscopy and parallel statistical analysis were used to identify differences in bone composition between healthy and ROD bone tissues through direct visualization of three main compositional parametric ratios, namely, calcium content, mineral-to-matrix, and carbonate-to-matrix. Besides the substantially lower values found in ROD specimens for these representative ratios, an obvious accumulation of phenylalanine is Raman spectroscopically observed for the first time in ROD samples and reported here. Read More

Endocrinol Diabetes Metab Case Rep 2018 8;2018. Epub 2018 Mar 8.

Endocrinology Department, Townsville Hospital, Townsville, Queensland, Australia.

Primary hyperparathyroidism (PH) is a common endocrine abnormality and may occur as part of a genetic syndrome. Inactivating mutations of the tumour suppressor gene have been identified as accounting for a large percentage of hyperparathyroidism-jaw tumour syndrome (HPT-JT) cases and to a lesser degree account for familial isolated hyperparathyroidism (FIHP) cases. Reports of whole gene deletions are exceedingly rare. Read More

Medicine (Baltimore) 2018 Feb;97(8):e9889

Department of Nephrology, Shandong University Qilu Hospital, Jinan City, China.

Rationale: Acute kidney injury (AKI) with hyperparathyroidism caused by nitrite was rare, and renal function and parathyroid hormone (PTH) decreased to normal range after therapy.

Patient Concerns: Acute kidney injury was diagnosed in a 40-year-old male with hyperparathyroidism and cyanosis of his hands and both forearms.

Diagnoses: The patient ate some recently pickled vegetables, and he experienced nausea, vomiting and diarrhoea without oliguria or anuria; Additionally, his hands and both forearms had a typical blue ash appearance. Read More

BMC Musculoskelet Disord 2018 02 13;19(1):53. Epub 2018 Feb 13.

Department of Osteology and Biomechanics, University Medical Center Hamburg-Eppendorf, Lottestraße 59, 22529, Hamburg, Germany.

Background: Impaired bone quality is associated with poor outcome of spinal surgery. The aim of the study was to assess the bone mineral status of patients scheduled to undergo spinal surgery and to report frequencies of bone mineral disorders.

Methods: We retrospectively analyzed the bone mineral status of 144 patients requiring spinal surgery including bone mineral density by dual-energy X-ray absorptiometry (DXA) as well as laboratory data with serum levels of 25-hydroxyvitamin D (25-OH-D), parathyroid hormone, calcium, bone specific alkaline phosphate, osteocalcin, and gastrin. Read More

Foot Ankle Surg 2018 Feb 22;24(1):71-75. Epub 2017 Sep 22.

Department of Foot and Hand Surgery, Agaplesion Diakonieklinikum Hamburg, Hohe Weide 17, 20259 Hamburg, Germany.

We report the case of a 35-year-old woman with painful, nontender mass at the right lateral hindfoot. Computed tomography (CT) and magnetic resonance imaging (MRI) indicated the suspect of a chondroid tumour in the cuboid. The tumour was resected en bloc and histology revealed the presence of a periosteal (juxtacortical) chondroma with secondary aneurysmal bone cyst. Read More

BMC Nephrol 2018 02 2;19(1):24. Epub 2018 Feb 2.

Musculoskeletal Disease Center, VA Loma Linda Healthcare System, 11201 Benton Street, Loma Linda, CA, 92357, USA.

Background: Changes in mineral metabolism and bone structure develop early in the course of chronic kidney disease and at end-stage are associated with increased risk of fragility fractures. The disruption of phosphorus homeostasis leads to secondary hyperparathyroidism, a common complication of chronic kidney disease. However, the molecular pathways by which high phosphorus influences bone metabolism in the early stages of the disease are not completely understood. Read More

G Ital Nefrol 2018 Feb;35(1)

SOC Nefrologia e Dialisi Firenze II.

Disorders of calcium-phosphate-parathormone balance, are very important issues in ESRD patients, that may lead to severe complications, as dystrophic calcinosis cutis, a rare disease, caused by calcium salt deposits in cutaneous or subcutaneous tissues and many organs. We present the case of a 47 years old woman, in ESRD due to membranous glomerulopathy, treated by peritoneal dialysis, who, after 7 months of dialysis, developed painful masses on second finger and fifth metacarpus of the right hand. Laboratory and instrumental data showed hyperparathyroidism with a parathyroid mass consistent with adenoma. Read More

Clin Cases Miner Bone Metab 2017 Sep-Dec;14(3):354-358. Epub 2017 Dec 27.

King Faisal Specialist Hospital and Research Centre Riyadh, Saudi Arabia.

Neonatal severe hyperparathyroidism (NSHPT) is a rare autosomal recessive disease. Children present within the first 6 months of life and more commonly in the first few weeks. Common presentation is poor feeding, polyuria, dehydration, lethargy, failure to thrive, hypotonia, gastrointestinal dysmotility, osteopenia and symptoms of respiratory distress due to a poorly developed chest cage. Read More

Folia Med (Plovdiv) 2017 12;59(4):396-404

Complex Oncology Center, Plovdiv, Bulgaria

Considered rare disease in the past, primary hyperparathyroidism (PHPT) has dramatically increased in incidence over the past thirty years with the introduction of routine calcium measurements; it is now approximately 42 per 100 000 persons. By far, the most common lesion found in patients with PHPT is the solitary parathyroid adenoma, occurring in 85%-90% of patients, while in the rest 10%- 15% primary hyperplasia of the parathyroid glands is present. Currently, the most widely used surgical approach is minimally invasive parathyroidectomy which is associated with less post-surgery complications and shorter operation time. Read More

Am J Otolaryngol 2018 Mar - Apr;39(2):138-141. Epub 2017 Dec 13.

Department of Head and Neck Surgery, RenJi Hospital, Shanghai JiaoTong University, School of Medicine, Shanghai 200001, China. Electronic address:

Objective: To investigate the combined use of a nanocarbon (NC) suspension and low-dose Tc-MIBI for parathyroid localization during surgery in patients with secondary hyperparathyroidism (sHPT).

Methods: Between March 2010 and September 2015, 40 patients with sHPT were enrolled in this study and were randomized to receive either low-dose Tc-MIBI+NC (group I) or low-dose Tc-MIBI (group II). Pre- and post-operative serum levels of intact PTH (iPTH), calcium and phosphorus between groups were compared and the intra-operative radioactive counts of the parathyroid glands were measured. Read More

Oral Surg Oral Med Oral Pathol Oral Radiol 2018 03 7;125(3):e37-e41. Epub 2017 Dec 7.

OMFS-IMPATH Research Group, Department Imaging & Pathology, Faculty of Medicine, University Leuven, Leuven, Belgium; Department of Oral and Maxillofacial Surgery, Leuven University Hospitals, Leuven, Belgium.

We present the case of a 32-year-old male patient complaining of recurrent mandibular pain for 3.5 years. Panoramic radiography indicated increased cortical density of the mandibular lower border. Read More

BMJ Case Rep 2017 Dec 22;2017. Epub 2017 Dec 22.

Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, NYU School of Medicine, New York City, New York, USA.

A middle-aged woman with obesity, hyperlipidaemia and diet-controlled diabetes was referred for resistant hypertension. Her blood pressure (BP) was uncontrolled on five medications, including a diuretic. Physical exam revealed a systolic ejection murmur, and ECHO demonstrated moderate hypertrophy. Read More

BMC Med Imaging 2017 Dec 12;17(1):60. Epub 2017 Dec 12.

Department of Nuclear Medicine, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, 160 Pujian Road, Pudong District, Shanghai, 200127, China.

Background: We aimed to evaluate the diagnostic performance of Tc-MIBI SPECT/CT and ultrasonography in patients with secondary hyperparathyroidism (SHPT), and explored the factors that affect the diagnostic performance.

Methods: Tc-MIBI SPECT/CT and ultrasonography were performed in 50 patients with SHPT within 1 month before they underwent surgery. Imaging results were confirmed by the pathology. Read More

J Med Case Rep 2017 Dec 9;11(1):342. Epub 2017 Dec 9.

Department of Nuclear Medicine, Ibn Sina Hospital, Mohammed V University, Rabat, Morocco.

Background: Primary hyperparathyroidism revealed by a pathological fracture is very uncommon; in the majority of cases the discovery of lytic bone lesions on imaging examinations evokes in the clinician first a neoplastic etiology and a metabolic origin is often omitted. This case report adds to the existing literature as it describes an unusual presentation of primary hyperparathyroidism.

Case Presentation: We report a case of a 50-year-old Moroccan man, without any known tumor, who presented a fracture of his left clavicle with multiple osteolytic lesions on computed tomography suggesting bone metastases. Read More

G Ital Nefrol 2017 Dec 5;34(Nov-Dec). Epub 2017 Dec 5.

Department of Medicine, Section of Internal Medicine D, University of Verona, Italy.

Histomorphometry or quantitative histology is the analysis on histologic sections of bone resorption, formation and structure parameters. It is the only technique allowing a dynamic evaluation of osteoblast activity after labelling with tetracycline. In addition, the use of computed image analyzer allows the possibility to assess bone microarchitecture. Read More

G Ital Nefrol 2017 Dec 5;34(Nov-Dec). Epub 2017 Dec 5.

Bone Clinic, Dipartimento delle Cure Geriatriche, Ortogeriatria e Riabilitazione, Ospedale Galliera, Genova, Italia.

Fragility fractures (FF) are common in patients with chronic kidney disease (CKD), and they occur at a younger age and with a higher frequency than in the general population, producing significant morbidity, mortality and healthcare costs. The pathogenic mechanisms underlying FF in CKD patients have not been completely understood. Behind CKD-MBD, the uremic toxicity should play a role in their pathogenesis, by affecting bone quality (uremic osteoporosis). Read More

Nefrologia 2018 Jan - Feb;38(1):99-101. Epub 2017 Dec 6.

Unidad de Trasplante Renal, Hospital Clínic, Barcelona, España.

Diagn Cytopathol 2018 Apr 29;46(4):355-361. Epub 2017 Nov 29.

Department of Pathology, Penn State Health, Milton S. Hershey Medical Center & Penn State College of Medicine, Hershey, Pennsylvania.

We report a case of a 72 year old male with hyperparathyroidism secondary to end stage diabetic renal disease and coexisting bilateral chromophobe renal cell carcinomas. The patient presented with back and groin pain, right pelvic hemorrhage, and multiple lytic bone lesions concerning for metastatic renal cell carcinoma. Fine needle aspiration cytology demonstrated benign appearing osteoclasts and spindled cells. Read More

J Vet Intern Med 2018 Jan 30;32(1):280-287. Epub 2017 Nov 30.

Koret School of Veterinary Medicine, Hebrew University of Jerusalem, Rehovot, Israel.

Background: Chronic kidney disease (CKD) is common in companion animals. Secondary hyperparathyroidism is an inevitable consequence of the disease and may have deleterious effect on the bone; however, the information regarding CKD-associated bone abnormalities in companion animals is scarce.

Hypothesis/objectives: Dogs with CKD have decreased bone quality compared to dogs without CKD. Read More

Ned Tijdschr Geneeskd 2017 ;161:D1782

Canisius Wilhelmina Ziekenhuis, afd. Longziekten, Nijmegen.

We present a 62-year-old man with a kidney transplant in the past. Because of progressive dyspnoea a CT-scan was made, which showed ground glass in the upper fields with calcifications. He was diagnosed with metastatic pulmonary calcification, which is mostly seen in patient with renal failure and secondary hyperparathyroidism. Read More

Pediatrics 2017 Dec;140(6)

Sections of Nephrology, Bone and Mineral Disorder Clinic, and

Secondary hyperparathyroidism (SHPT) is a rare complication of furosemide therapy that can occur in patients treated with the loop diuretic for a long period of time. We report a 6-month-old 28-weeks premature infant treated chronically with furosemide for his bronchopulmonary dysplasia, who developed hypocalcemia and severe SHPT, adversely affecting his bones. Discontinuation of the loop diuretic and the addition of supplemental calcium and calcitriol only partially reversed the SHPT, bringing serum parathyroid hormone level down from 553 to 238 pg/mL. Read More

Int J Mol Imaging 2017 18;2017:2712018. Epub 2017 Oct 18.

Turku PET Centre, Turku University Hospital, P.O. Box 52, 20521 Turku, Finland.

Objectives: This retrospective study evaluated whether the use of additional anterior Tc-sestamibi/I pinhole imaging improves the outcome of Tc-sestamibi/I subtraction SPECT/CT in parathyroid scintigraphy (PS).

Materials And Methods: PS using simultaneous dual-isotope subtraction methods and an acquisition protocol combining SPECT/CT and planar pinhole imaging was performed for 175 patients with primary or secondary hyperparathyroidism. All patients who proceeded to surgery with complete postsurgery laboratory findings were included in this study ( = 94). Read More

Hell J Nucl Med 2017 Sep-Dec;20(3):258-259. Epub 2017 Nov 27.

Department of Internal Medicine, Naval Hospital of Crete, Souda 73 200, Chania, Crete, Greece.

The patients with Hashimoto thyroiditis must be investigated mainly for secondary hyperparathyroidism due to vitamin D deficiency/insufficiency. Parathyroid scintigraphy has no place in the diagnosis of primary, secondary or tertiary hyperparathyroidism or in the decision for surgical treatment. Parathyroid scintigraphy is a useful preoperative technique for the localization of the pathological parathyroid glands. Read More