2,213,719 results match your criteria Imaging in Secondary Hyperparathyroidism

Nonalcoholic Fatty Liver Disease and Cardiovascular Disease: Overlapping Mechanisms.

Semin Liver Dis 2021 May 15. Epub 2021 May 15.

Department of Clinical Medicine, University of Copenhagen, Denmark.

Nonalcoholic fatty liver disease (NAFLD) denotes a condition with excess fat in the liver. The prevalence of NAFLD is increasing, averaging > 25% of the Western population. In 25% of the patients, NAFLD progresses to its more severe form: nonalcoholic steatohepatitis and >25% of these progress to cirrhosis following activation of inflammatory and fibrotic processes. Read More

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Impaired global efficiency in boys with conduct disorder and high callous unemotional traits.

J Psychiatr Res 2021 Apr 29;138:560-568. Epub 2021 Apr 29.

Medical Psychological Center, The Second Xiangya Hospital, Central South University, Changsha, China; National Clinical Research Center on Psychiatry and Psychology, Changsha, China; Medical Psychological Institute of Central South University, Changsha, China; National Clinical Research Center for Mental Disorders, Changsha, China. Electronic address:

Callous unemotional (CU) traits differentiate subtypes of conduct disorder (CD). It has been suggested that CU traits may be related to topographical irregularities that hinder information integration. To date, there is limited evidence of whether CU traits may be associated with abnormal brain topology. Read More

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In vitro cellular activity of maghemite/cerium oxide magnetic nanoparticles with antioxidant properties.

Colloids Surf B Biointerfaces 2021 May 6;204:111824. Epub 2021 May 6.

Institute of Macromolecular Chemistry, Czech Academy of Sciences, Heyrovského nám. 2, 162 06, Prague 6, Czech Republic. Electronic address:

Magnetic γ-FeO/CeO nanoparticles were obtained by precipitation of Ce(NO) with ammonia in the presence of γ-FeO seeds. The formation of CeO nanoparticles on the seeds was confirmed by transmission electron microscopy linked with selected area electron diffraction, energy-dispersive X-ray spectroscopy, electron energy loss spectroscopy, and dynamic light scattering. The γ-FeO/CeO particle surface was functionalized with PEG-neridronate to improve the colloidal stability in PBS and biocompatibility. Read More

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Neurite orientation dispersion and density imaging in evaluation of high-grade glioma-induced corticospinal tract injury.

Eur J Radiol 2021 May 2;140:109750. Epub 2021 May 2.

MR Scientific Marketing, Siemens Healthcare, Shanghai, 201318, China.

Purpose: To evaluate the application of neurite orientation dispersion and density imaging (NODDI) to brain glioma-induced corticospinal tract (CST) injury.

Material And Methods: Twenty-four patients with high-grade glioma (HGG) in or adjacent to the CST pathway and 12 matched healthy subjects underwent structural and diffusion MRI. The CSTs were reconstructed on the both sides. Read More

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G-triplex: A new type of CRISPR-Cas12a reporter enabling highly sensitive nucleic acid detection.

Biosens Bioelectron 2021 May 9;187:113292. Epub 2021 May 9.

State Key Laboratory of Magnetic Resonance and Atomic Molecular Physics, Wuhan National Laboratory for Optoelectronics, National Centre for Magnetic Resonance in Wuhan, Wuhan Institute of Physics and Mathematics, Innovation Academy for Precision Measurement Science and Technology, Chinese Academy of Sciences - Wuhan National Laboratory for Optoelectronics, Huazhong University of Science and Technology, Wuhan, 430071, China; University of Chinese Academy of Sciences, Beijing, 10049, China. Electronic address:

CRISPR-Cas12a (Cpf1) trans-cleaves ssDNA and this feature has been widely harnessed for nucleic acid detection. Herein, we introduce a new type of Cas12a reporter, G-triplex (G3), and a highly sensitive biosensor termed G-CRISPR. We proved that Cas12a trans-cleaves G3 structures in about 10 min and G3 can serve as an excellent reporter based on the cleavage-induced high-order structure disruption. Read More

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Childhood trauma is linked to decreased temporal stability of functional brain networks in young adults.

J Affect Disord 2021 May 2;290:23-30. Epub 2021 May 2.

Department of Psychiatry, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China; Mental Health Institute of Central South University, Changsha, Hunan, China; China National Clinical Research Center on Mental Disorders, Changsha, Hunan, China. Electronic address:

Background: Both childhood trauma and disruptions in brain functional networks are implicated in the development of psychiatric disorders in early adulthood. However, the relationships between these two factors remain unclear. This study aimed to investigate whether and how childhood trauma would relate to changes of functional network dynamics in young adults. Read More

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Prevalence and associated risk factors of coronary artery disease in patients with a zero coronary calcium score.

Clin Imaging 2021 May 10;77:207-212. Epub 2021 May 10.

Department of Radiology, Faculty of Medicine, Gazi University, Emniyet, Mevlana Blv. No:29, 06560 Yenimahalle, Ankara, Türkiye.

Purpose: A zero coronary calcium score (CCS) is not able to provide a definite exclusion for coronary artery disease (CAD). The goal of this study was to determine the prevalence and associated cardiovascular risk factors of CAD in patients with zero CCS.

Methods: Six hundred thirteen patients with zero CCS referred to coronary calcium score analysis (CCSA) and coronary computed tomography angiography (CCTA) with suspicion of CAD were included. Read More

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MRI-visible perivascular space volumes, sleep duration and daytime dysfunction in adults with cerebrovascular disease.

Sleep Med 2021 Apr 19;83:83-88. Epub 2021 Apr 19.

Hurvitz Brain Sciences Program, Sunnybrook Research Institute, University of Toronto, Toronto, ON, Canada; Department of Medicine (Neurology), Sunnybrook Health Sciences Centre and University of Toronto, ON, Canada.

Objectives: Recent studies suggest that interindividual genetic differences in glial-dependent CSF flow through the brain parenchyma, known as glymphatic flow, may trigger compensatory changes in human sleep physiology. In animal models, brain perivascular spaces are a critical conduit for glymphatic flow. We tested the hypothesis that MRI-visible PVS volumes, a putative marker of perivascular dysfunction, are associated with compensatory differences in real-world human sleep behavior. Read More

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Chronic sleep restriction triggers inadequate napping habits in adolescents: a population-based study.

Sleep Med 2021 Apr 19;83:115-122. Epub 2021 Apr 19.

Human Chronobiology Laboratory, Department of Physiology, Biological Sciences Sector, Federal University of Paraná, Curitiba, Paraná, Brazil. Electronic address:

Background: The prevalence of chronic sleep restriction during adolescence is a major public health issue. Napping has been adopted to alleviate sleep pressure complaints. However, it also has the potential to amplify sleep restriction due to a vicious cycle triggered by delayed sleep times. Read More

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Predictive processing, cognitive control, and tonality stability of music: An fMRI study of chromatic harmony.

Brain Cogn 2021 May 12;151:105751. Epub 2021 May 12.

Graduate Institute of Musicology, National Taiwan University, Taipei, Taiwan; Neurobiology and Cognitive Science Center, National Taiwan University, Taipei, Taiwan. Electronic address:

The present study aimed at identifying the brain regions which preferentially responded to music with medium degrees of key stability. There were three types of auditory stimuli. Diatonic music based strictly on major and minor scales has the highest key stability, whereas atonal music has the lowest key stability. Read More

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On the dependence of quantitative diffusion-weighted imaging on scanner system characteristics and acquisition parameters: A large multicenter and multiparametric phantom study with unsupervised clustering analysis.

Phys Med 2021 May 12;85:98-106. Epub 2021 May 12.

S.C. Fisica Sanitaria, A.S.S.T. Monza, Monza, Italy.

Purpose: The purpose of this multicenter phantom study was to exploit an innovative approach, based on an extensive acquisition protocol and unsupervised clustering analysis, in order to assess any potential bias in apparent diffusion coefficient (ADC) estimation due to different scanner characteristics. Moreover, we aimed at assessing, for the first time, any effect of acquisition plan/phase encoding direction on ADC estimation.

Methods: Water phantom acquisitions were carried out on 39 scanners. Read More

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The role of CT in planning percutaneous structural heart interventions: Where to measure and why.

Clin Imaging 2021 May 1;76:247-264. Epub 2021 May 1.

Department of Radiology, University of Washington, Puget Sound Veterans Administration Hospital, 1959 NE Pacific Street, Room BB308, Box 357115, Seattle, WA 98195, USA. Electronic address: https://twitter.com/sbastawrous1.

As research continues to demonstrate successes in the use of percutaneous trans-vascular techniques in structural heart intervention, both the subspecialty trained and non-subspecialty trained cardiac imager find themselves performing and reporting larger amounts of information regarding cardiovascular findings. It is therefore imperative that the imager gains understanding and appreciation for how these various measurements are obtained, as well as their implication in a patient's care. Cardiac gated computed tomography (CT) has solidified its role and ability at providing high resolution images that can be used to obtain the key measurements used in structural heart intervention planning. Read More

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Imaging, histopathological degree of degeneration and clinical findings - Do these correlate in patients with temporomandibular joint disorders.

J Stomatol Oral Maxillofac Surg 2021 May 12. Epub 2021 May 12.

Department of Oral and Maxillofacial Surgery, University Hospital Erlangen, Friedrich-Alexander-University Erlangen Nuremberg, Glückstraße 11, 91054 Erlangen, Germany; Section of Oral and Maxillofacial Surgery, Department of Otorhinolaryngology, University Hospital Augsburg, Stenglinstraße 2, 86156 Augsburg, Germany.

The gold standard for temporomandibular joint imaging is magnetic resonance imaging, although there are still pathological findings that cannot be seen in MRI but in surgery and the subsequent histological analysis only. The main goal of this investigation was to validate the MRI score used by histopathological findings as well as clinical findings. In this retrospective study 39 patients were included; 38 of which underwent unilateral and 1 underwent bilateral discectomy. Read More

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Total IgE variability is associated with future asthma exacerbations: a one-year prospective cohort study.

J Allergy Clin Immunol Pract 2021 May 12. Epub 2021 May 12.

Airway Physiology and Imaging Group and the Woolcock Emphysema Centre, The Woolcock Institute of Medical Research, Sydney, NSW, Australia; Discipline of Medical Sciences, School of Life Sciences, University of Technology Sydney, Sydney, NSW, Australia.

Background: Few prospective studies have investigated the relationship between IgE variability and risk of asthma exacerbations (AEs).

Objective: To explore the relationship between IgE variability and AEs.

Methods: Recruited patients with stable asthma underwent two serum total IgE tests within a month (at screening [baseline IgE] and one-month) to obtain coefficient of variation (CV) of base-10 log-transformed IgE. Read More

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Hippocampal and striatal responses during motor learning are modulated by prefrontal cortex stimulation.

Neuroimage 2021 May 12:118158. Epub 2021 May 12.

Department of Movement Sciences, Movement Control and Neuroplasticity Research Group, KU Leuven, 3001 Leuven, Belgium; LBI - KU Leuven Brain Institute, KU Leuven, 3001 Leuven, Belgium. Electronic address:

While it is widely accepted that motor sequence learning (MSL) is supported by a prefrontal-mediated interaction between hippocampal and striatal networks, it remains unknown whether the functional responses of these networks can be modulated in humans with targeted experimental interventions. The present proof-of-concept study employed a multimodal neuroimaging approach, including functional magnetic resonance (MR) imaging and MR spectroscopy, to investigate whether individually-tailored theta-burst stimulation of the dorsolateral prefrontal cortex can modulate responses in the hippocampus and the basal ganglia during motor learning. Our results indicate that while stimulation did not modulate motor performance nor task-related brain activity, it influenced connectivity patterns within hippocampo-frontal and striatal networks. Read More

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Inter-regional BOLD signal variability is an organizational feature of functional brain networks.

Neuroimage 2021 May 12:118149. Epub 2021 May 12.

Montréal Neurological Institute, Department of Neurology and Neurosurgery, Montréal, QC H3A 2B4; Douglas Mental Health University Institute, Montréal, QC H4H 1R3; McConnell Brain Imaging Center, McGill University, Montréal, QC H3A 2B4; Departments of Psychiatry and Psychology, McGill University, Montréal, QC H3A 1G1. Electronic address:

Neuronal variability patterns promote the formation and organization of neural circuits. Macroscale similarities in regional variability patterns may therefore be linked to the strength and topography of inter-regional functional connections. To assess this relationship, we used multi-echo resting-state fMRI and investigated macroscale connectivity-variability associations in 154 adult humans (86 women; mean age = 22yrs). Read More

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Deep Recurrent Model for Individualized Prediction of Alzheimer's Disease Progression.

Neuroimage 2021 May 12:118143. Epub 2021 May 12.

Department of Brain and Cognitive Engineering, Korea University, Seoul 02841, Republic of Korea; Department of Artificial Intelligence, Korea University, Seoul 02841, Republic of Korea.

Alzheimer's disease (AD) is known as one of the major causes of dementia and is characterized by slow progression over several years, with no treatments or available medicines. In this regard, there have been efforts to identify the risk of developing AD in its earliest time. While many of the previous works considered cross-sectional analysis, more recent studies have focused on the diagnosis and prognosis of AD with longitudinal or time series data in a way of disease progression modeling. Read More

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Current clinical applications and potential perspective of micro-computed tomography in cardiovascular imaging: A systematic scoping review.

Hellenic J Cardiol 2021 May 12. Epub 2021 May 12.

First Department of Cardiology, AHEPA University Hospital, Aristotle University of Thessaloniki, St. Kiriakidi 1, 54636, Thessaloniki, Greece. Electronic address:

Background: Micro-computed tomography (micro-CT) constitutes an emerging imaging technique, which can be utilized in cardiovascular medicine to study in-detail the microstructure of heart and vessels. This paper aims to systematically review the clinical utility of micro-CT in cardiovascular imaging and propose future applications of micro-CT imaging in cardiovascular research.

Methods: A systematic scoping review was conducted by searching for original studies written in English according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) extension for scoping reviews. Read More

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Long Term Outcomes After Arthroscopic Transosseous Equivalent Repair: Clinical and MRI Results of Rotator Cuff Tears at a Minimum Follow-up of 10 Years.

J Shoulder Elbow Surg 2021 May 12. Epub 2021 May 12.

Department of Orthopedics and Traumatology, Koc University School of Medicine, Istanbul, Turkey. Electronic address:

Purpose: The objective of this study was to evaluate long-term functional outcomes and structural integrity of medium to massive rotator cuff tears at 10 to 12 years of follow-up after arthroscopic transosseous equivalent repair (TOE).

Methods: A retrospective view was performed on a consecutive series of patients who underwent primary arthroscopic TOE repair of medium to massive size degenerative rotator cuff tears by a single surgeon between January 2007 and August 2009. Patients were examined at a minimum follow-up of 10 years and magnetic resonance imaging (MRI) was performed to assess tendon integrity. Read More

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Elezanumab, a human anti-RGMa monoclonal antibody, promotes neuroprotection, neuroplasticity, and neurorecovery following a thoracic hemi-compression spinal cord injury in non-human primates.

Neurobiol Dis 2021 May 12:105385. Epub 2021 May 12.

Department of Neurosurgery and The Miami Project to Cure Paralysis, The Miller School of Medicine, University of Miami, Miami, FL, United States.

Spinal cord injury (SCI) is a devastating condition characterized by loss of function, secondary to damaged spinal neurons, disrupted axonal connections, and myelin loss. Spontaneous recovery is limited, and there are no approved pharmaceutical treatments to reduce ongoing damage or promote repair. Repulsive guidance molecule A (RGMa) is upregulated following injury to the central nervous system (CNS), where it is believed to induce neuronal apoptosis and inhibit axonal growth and remyelination. Read More

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Diagnostic accuracy of elastography and magnetic resonance imaging in patients with NAFLD: a systematic review and meta-analysis.

J Hepatol 2021 May 12. Epub 2021 May 12.

Oxford Centre for Clinical Magnetic Resonance Research, Radcliffe Department of Medicine, University of Oxford, Oxford, UK; Translational Gastroenterology Unit, Nuffield Department of Medicine, University of Oxford, Oxford, UK; Oxford NIHR Biomedical Research Centre, Oxford University Hospitals NHS Foundation Trust and the University of Oxford, Oxford, UK. Electronic address:

Background And Aims: Vibration-controlled transient elastography (VCTE), point shear wave elastography (pSWE), two-dimensional shear wave elastography (2DSWE), magnetic resonance elastography (MRE), and magnetic resonance imaging (MRI) are proposed as non-invasive tests for patients with non-alcoholic fatty liver disease (NAFLD). This study evaluated their diagnostic accuracy for liver fibrosis and non-alcoholic steatohepatitis (NASH).

Methods: PubMED/MEDLINE, EMBASE and the Cochrane Library were searched for studies examining the diagnostic accuracy of these index tests against histology as the reference standard, in adult patients with NAFLD. Read More

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Lower urinary tract function in patients with inflammatory encephalomyelopathy: characteristics of urodynamics, neurological deficits and magnetic resonance imaging.

Urology 2021 May 12. Epub 2021 May 12.

Department of Urology, China Rehabilitation Research Center,; Department of Urology of Capital Medical University. Electronic address:

Objective: To report the clinical data in a large population of patients affected by inflammatory encephalomyelopathy.

Material And Methods: We retrospectively reviewed the medical history, imaging studies and urodynamic findings in a series of 87 consecutive patients with inflammatory encephalomyelopathy. Age at disease onset ranged from 3 to 76 years with an average of 35. Read More

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Neurophysiological tracking of speech-structure learning in typical and dyslexic readers.

Neuropsychologia 2021 May 12:107889. Epub 2021 May 12.

Maastricht Brain Imaging Center, Department of Cognitive Neuroscience, Faculty of Psychology and Neuroscience, Maastricht University, Maastricht, Netherlands.

Statistical learning, or the ability to extract statistical regularities from the sensory environment, plays a critical role in language acquisition and reading development. Here we employed electroencephalography (EEG) with frequency-tagging measures to track the temporal evolution of speech-structure learning in individuals with reading difficulties due to developmental dyslexia and in typical readers. We measured EEG while participants listened to (a) a structured stream of repeated tri-syllabic pseudowords, (b) a random stream of the same isochronous syllables, and (c) a series of tri-syllabic real Dutch words. Read More

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What is the actual accuracy of clinical prediction models? The case of transition to psychosis.

Joaquim Radua

Neurosci Biobehav Rev 2021 May 12. Epub 2021 May 12.

Imaging of Mood- and Anxiety-Related Disorders (IMARD) group, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), CIBERSAM, Barcelona, Spain; Department of Psychosis Studies, Institute of Psychiatry, Psychology, and Neuroscience, King's College London, London, UK; Department of Clinical Neuroscience, Centre for Psychiatric Research and Education, Karolinska Institutet, Stockholm, Sweden. Electronic address:

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Non-invasive, neurotoxic surgery reduces seizures in a rat model of temporal lobe epilepsy.

Exp Neurol 2021 May 12:113761. Epub 2021 May 12.

Department of Radiology, Neuroradiology Division, Stanford University, CA, USA. Electronic address:

Surgery can be highly effective for treating certain cases of drug resistant epilepsy. The current study tested a novel, non-invasive, surgical strategy for treating seizures in a rat model of temporal lobe epilepsy. The surgical approach uses magnetic resonance-guided, low-intensity focused ultrasound (MRgFUS) in combination with intravenous microbubbles to open the blood-brain barrier (BBB) in a transient and focal manner. Read More

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Consideration triggered by the choice of heterophilic antibody interference detection tests in measuring ACTH for a teenager boy with a rare adrenal disease.

Clin Chim Acta 2021 May 12. Epub 2021 May 12.

Department of Clinical Laboratory, Peking Union Medical College Hospital, Peking Union Medical College & Chinese Academy of Medical Science, Beijing 100730, P.R. China. Electronic address:

Background: Plasma ACTH is an important marker for Cushing syndrome; inaccurate measurement of ACTH concentrations due to the serum heterophile antibody may mislead diagnosis by physicians. We describe the case of a teenage boy with a rare adrenal disease who presented falsely increased ACTH concentrations (20.3 pg/ml; Siemens Immulite). Read More

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A novel swine model of the acute respiratory distress syndrome using clinically relevant injury exposures.

Physiol Rep 2021 May;9(9):e14871

Michigan Center for Integrative Research in Critical Care, University of Michigan, Ann Arbor, MI, USA.

To date, existing animal models of the acute respiratory distress syndrome (ARDS) have failed to translate preclinical discoveries into effective pharmacotherapy or diagnostic biomarkers. To address this translational gap, we developed a high-fidelity swine model of ARDS utilizing clinically relevant lung injury exposures. Fourteen male swine were anesthetized, mechanically ventilated, and surgically instrumented for hemodynamic monitoring, blood, and tissue sampling. Read More

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The use of statistical modelling to identify important parameters for the shape of the torso following surgery for adolescent idiopathic scoliosis.

J Anat 2021 May 15. Epub 2021 May 15.

Institute of Clinical Science, University of Birmingham, Birmingham, UK.

The surgical strategy in adolescent idiopathic scoliosis (AIS) aims to recreate the symmetry of the torso. This requires the minimisation of both the size of the scoliosis and the angulation between the sides of the torso, along with the recreation of a normal thoracic kyphosis. This study uses predictive modelling to identify the significance of the value of the pre-operative parameters, and the change in the magnitude of the parameters as a result of an operation on the shape of the torso using the 'most prominent points'; two areas of maximum prominence on either side of the spine with x, y and z coordinates. Read More

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A comparative study of breed differences in the anatomical configuration of the equine vertebral column.

J Anat 2021 May 15. Epub 2021 May 15.

Department of Clinical Sciences, Equine Division, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands.

The importance of the equine thoracolumbar vertebral column in orthopaedic disorders is well recognized and diagnostic imaging becomes more feasible, but little is known about variations in the anatomical configuration within breeds. In this descriptive post-mortem study, anatomical variations in three widely differing breeds: Warmblood horses, Shetland ponies and semi-feral Konik horses are described. The caudal cervical (C), thoracic (T), lumbar (L) and sacral (S) regions of the vertebral column of 30 Warmblood horses, 29 Shetland ponies and 18 Konik horses were examined using computed tomography and visualized by volume rendering. Read More

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