3,730 results match your criteria Imaging in Prostate Carcinoma


Porous Silicon as a Platform for Radiation Theranostics Together with a Novel RIB-Based Radiolanthanoid.

Contrast Media Mol Imaging 2019 12;2019:3728563. Epub 2019 Mar 12.

Department of Chemistry, University of Helsinki, FI-00014 Helsinki, Finland.

Mesoporous silicon (PSi) is biocompatible and tailorable material with high potential in drug delivery applications. Here, we report of an evaluation of PSi as a carrier platform for theranostics by delivering a radioactive ion beam- (RIB-) based radioactive lanthanoid into tumors in a mouse model of prostate carcinoma. Thermally hydrocarbonized porous silicon (THCPSi) wafers were implanted with Dy at the facility for radioactive ion beams ISOLDE located at CERN, and the resulting [Dy]THCPSi was postprocessed into particles. Read More

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http://dx.doi.org/10.1155/2019/3728563DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6434306PMC

Ga-PSMA PET thyroid incidentalomas.

Hormones (Athens) 2019 Apr 15. Epub 2019 Apr 15.

Department of Nuclear Medicine and PET/CT Center, Oncology Institute of Southern Switzerland, Bellinzona, Switzerland.

Introduction: Thyroid incidentaloma is defined as a thyroid lesion incidentally and newly detected by imaging techniques performed for an unrelated purpose and especially for a non-thyroid disease. The aim of this review is to evaluate the prevalence and clinical significance of focal incidental radiolabelled prostate-specific membrane antigen (PSMA) uptake in the thyroid gland [PSMA thyroid incidentaloma (PTI)] revealed by PET/CT or PET/MRI.

Methods: A comprehensive literature search of the PubMed/MEDLINE, Scopus, and Embase databases was conducted to find relevant published articles about the prevalence and clinical significance of PTIs detected by PET/CT or PET/MRI in patients studied for other oncologic purposes. Read More

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http://dx.doi.org/10.1007/s42000-019-00106-8DOI Listing
April 2019
1 Read

The Impact of 68Ga-PSMA PET/CT and PET/MRI on the Management of Prostate Cancer.

Urology 2019 Apr 12. Epub 2019 Apr 12.

Specialist in Nuclear Medicine, Clinic of Nuclear Medicine, Johannes Gutenberg-University Mainz, 55131 Mainz, Germany.

Prostate-specific-membrane-antigen (PSMA) is a transmembrane protein with significantly increased expression in the cells and metastases of prostate carcinoma (PCa). PSMA-expression correlates with higher serum levels of prostate-specific-antigen (PSA) and a higher Gleason Score (GS). This finding has led to the development of novel imaging modalities such as 68Ga-/18F-labeled PSMA PET/CT and PET/MRI. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00904295193034
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http://dx.doi.org/10.1016/j.urology.2019.04.004DOI Listing
April 2019
3 Reads

Magnetic resonance imaging-guided transperineal prostate biopsy.

J Cancer Res Ther 2019 ;15(2):394-397

Department of Intervention, The First Affiliated Hospital of Fujian Medical University, Fuzhou, China.

Purpose: The purpose of the study is to assess the clinical value of magnetic resonance imaging (MRI)-guided transperineal prostate biopsy in the diagnosis of prostate disease.

Materials And Methods: The institutional ethics committee approved this study. MRI-guided transperineal prostate biopsy was performed on 78 patients who had presented to our hospital with a prostate-specific antigen level >4 ng/mL or with MRI scans suggesting prostate cancer between January 2015 and August 2017. Read More

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http://dx.doi.org/10.4103/jcrt.JCRT_725_18DOI Listing
January 2019
1 Read

Comparing histologic evaluation of prostate tissue using nonlinear microscopy and paraffin H&E: a pilot study.

Mod Pathol 2019 Mar 26. Epub 2019 Mar 26.

Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.

Rapid histological assessment of large areas of prostate tissue is required for many intraoperative consultation scenarios such as margin evaluation. Nonlinear microscopy (NLM) enables imaging of large (whole mount) specimens without freezing or cryotoming. This study demonstrates rapid histological imaging of unsectioned prostate cancer surgical specimens using nonlinear microscopy and compares features of prostate pathology to standard paraffin embedded H&E histology. Read More

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http://dx.doi.org/10.1038/s41379-019-0250-8DOI Listing

Nanomedical detection and downstream analysis of circulating tumor cells in head and neck patients.

Biol Chem 2019 Apr 22. Epub 2019 Apr 22.

Nanobiomedicine Department/Department of Otorhinolaryngology-Head and Neck Surgery/ENT, University Medical Center Mainz, Langenbeckstrasse 1, D-55131 Mainz, Germany.

The establishment of novel biomarkers in liquid biopsies of cancer patients has come more into focus in prognostic and diagnostic research efforts. Due to their prognostic relevance disseminated tumor cells or circulating tumor cells are the subject of intensive research and are discussed as early diagnostic indicators for treatment failure and the formation of micrometastases. A potential association of this early-systemic tumor component with poor prognosis of cancer patients could be already demonstrated for various entities including breast, colon, lung, melanoma, ovarian and prostate cancers. Read More

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http://dx.doi.org/10.1515/hsz-2019-0141DOI Listing
April 2019
1 Read

Stereotactic Body Radiotherapy - Current Indications.

Klin Onkol 2019 ;32(1):10-24

Background: Stereotactic body radiotherapy (SBRT) is used to treat localized tumor lesions and consists of applying high doses of radiation to a small number of fractions using specially equipped linear accelerators, modern immobilization devices, and imaging methods, which are considered special, advanced techniques in modern day radiotherapy. SBRT is a very well tolerated, non-invasive, short-term treatment that does not require hospitalization or any complicated preparation. Compared to standard radiotherapy techniques, SBRT allows, due to its precision, significantly higher doses to be applied to the target with less damage to surrounding healthy tissues. Read More

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http://dx.doi.org/10.14735/amko201910DOI Listing
April 2019
1 Read

A multicentre prospective clinical trial of Gallium PSMA HBED-CC PET-CT restaging in biochemically relapsed prostate carcinoma: Oligometastatic rate and distribution, compared to standard imaging.

Int J Radiat Oncol Biol Phys 2019 Mar 16. Epub 2019 Mar 16.

Molecular Imaging and Therapy Service (Nuclear Medicine), Royal Perth Hospital and Fiona Stanley Hospital, Perth, Australia; Medical Engineering and Physics, Royal Perth Hospital and Fiona Stanley Hospital, Perth, Australia.

Aim: This study is to assess the utility ofGallium PSMA HBED-CC PET/CT (PSMA-HBED), compared to standard imaging, in the detection of recurrent prostate carcinoma in patients with biochemical relapse, to determine the prevalence of oligometastatic disease recurrence and its distribution.

Method: This is a prospective, multicentre clinical trial of PSMA-HBED PET/CT imaging in patients with early biochemical relapse of prostate carcinoma (PCa) (median PSA 2.55ng/ml) following definitive prostatectomy (152 patients) or radiotherapy (86 patients) with either no lesions or oligometastatic disease on abdominopelvic CT (CT) and bone scan (BS). Read More

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http://dx.doi.org/10.1016/j.ijrobp.2019.03.014DOI Listing
March 2019
1 Read

Combined Robotic-assisted Laparoscopic Radical Prostatectomy and Partial Nephrectomy, Rare Coincidence.

Urology 2019 Mar 14. Epub 2019 Mar 14.

Ankara University School of Medicine, Department of Urology, Ankara, Turkey.

The incidence of second primary cancer detection in patients with prostate cancer undergoing cross-sectional imaging for staging workup is 1.5%. Concomitant prostate cancer and clear-cell renal cell carcinoma is a rare condition. Read More

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http://dx.doi.org/10.1016/j.urology.2019.02.031DOI Listing
March 2019
2 Reads

[Fusion biopsies for primary diagnosis of prostate cancer : Implementation, benefits, and clinical aspects].

Urologe A 2019 Mar 5. Epub 2019 Mar 5.

Klinik für Urologie, Universitätsklinikum Köln, Köln, Deutschland.

Prostate carcinoma is one of the most common tumors worldwide. Histological confirmation by biopsy is an obligatory part of the diagnostic approach. The main problem of the 10-12-fold transrectal ultrasound-guided (TRUS) biopsy, which has so far been regarded as the gold standard, is the underdiagnosis of clinically significant cancer. Read More

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http://dx.doi.org/10.1007/s00120-019-0889-2DOI Listing
March 2019
6 Reads

Lung Adenocarcinoma Metastasis to the Prostate: A Case Report.

Pract Radiat Oncol 2019 03;9(2):77-80

Department of Radiation Oncology, CHUV, Lausanne, Switzerland.

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http://dx.doi.org/10.1016/j.prro.2018.11.010DOI Listing

Uncommon Penio-Scrotal Metastases of Prostate Cancer Detected on 68Ga PSMA PET/CT.

Clin Nucl Med 2019 May;44(5):424-425

From the Department of Nuclear Medicine and PET/CT, Mahajan Imaging Centre, and.

A 68-year-old man, a known case of carcinoma prostate (Gleason score 4 + 4), status post transurethral resection of prostate cancer and radiotherapy, on hormonal treatment with rising prostate-specific antigen 9.0 ng/mL and penile swelling underwent Ga-PSMA PET/CT scan for metastatic workup and restaging. The study revealed abnormal tracer uptake in the prostatic bed region, the pelvic and inguinal lymph nodes, and metastases to the glans of penis and scrotum. Read More

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http://dx.doi.org/10.1097/RLU.0000000000002527DOI Listing
May 2019
2 Reads

Incidentally Detected Oropharyngeal Squamous Cell Carcinoma on 18F-Fluciclovine PET/CT.

Clin Nucl Med 2019 May;44(5):e367-e369

From the Division of Nuclear Medicine, Department of Radiology and Biomedical Imaging.

We present a case of oropharyngeal squamous cell carcinoma (SCC) of the tongue base incidentally detected on F-fluciclovine PET/CT. A 79-year-old man with history of locally advanced prostate cancer (Gleason score 4 + 5 = 9; cT2cN1M0) previously treated with androgen deprivation therapy (luprolide + bicalutamide) presented with a slowly rising serum prostate-specific antigen over 3 years, concerning for recurrent disease. F-fluciclovine PET/CT, obtained to identify potential sites of recurrence, demonstrated prostate bed uptake with possible left seminal vesicle involvement. Read More

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http://dx.doi.org/10.1097/RLU.0000000000002507DOI Listing
May 2019
11 Reads

Three-dimensional architecture of common benign and precancerous prostate epithelial lesions.

Histopathology 2019 Feb 28. Epub 2019 Feb 28.

Department of Pathology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.

Aims: Many glandular lesions can mimic prostate cancer microscopically, including atrophic glands, adenosis and prostatic intraepithelial neoplasia. While the characteristic histopathological and immunohistochemical features of these lesions have been well established, little is known about their three-dimensional architecture. Our objective was to evaluate the three-dimensional organisation of common prostate epithelial lesions. Read More

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http://dx.doi.org/10.1111/his.13848DOI Listing
February 2019
1 Read

Evaluation of [C]NMS-E973 as a PET tracer for visualisation of HSP90.

Theranostics 2019 1;9(2):554-572. Epub 2019 Jan 1.

Laboratory for Radiopharmaceutical Research, Department of Pharmacy and Pharmacology, KU Leuven, Leuven, Belgium.

Heat shock protein 90 is an ATP-dependent molecular chaperone important for folding, maturation and clearance of aberrantly expressed proteins and is abundantly expressed (1-2% of all proteins) in the cytosol of all normal cells. In some tumour cells, however, strong expression of HSP90 is also observed on the cell membrane and in the extracellular matrix and the affinity of tumoural HSP90 for ATP domain inhibitors was reported to increase over 100-fold compared to that of HSP90 in normal cells. Here, we explore [C]NMS-E973 as a PET tracer for visualisation of HSP90 and as a potential tool for quantification of occupancy of HSP90 inhibitors. Read More

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http://www.thno.org/v09p0554.htm
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http://dx.doi.org/10.7150/thno.27213DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6376183PMC
January 2019
7 Reads
7.827 Impact Factor

Imaging and Characterization of Macrophage Distribution in Mouse Models of Human Prostate Cancer.

Mol Imaging Biol 2019 Feb 25. Epub 2019 Feb 25.

The Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, 21287, USA.

Purpose: Prostate carcinoma consists of tumor epithelium and malignant stroma. Until recently, diagnostic and therapeutic efforts have focused exclusively on targeting characteristics of the tumor epithelium, ignoring opportunities to target inflammatory infiltrate and extracellular matrix components. Prostate tumors are rich in tumor-associated macrophages (TAMs), which can be either of the cytotoxic M1 or protumorigenic M2 phenotype. Read More

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http://dx.doi.org/10.1007/s11307-019-01318-5DOI Listing
February 2019
2 Reads

Transformation of adenocarcinoma of prostate to squamous cell carcinoma following hormonal treatment: A case report and review of the literature.

Authors:
Jihyun Lee

Radiol Case Rep 2019 Apr 11;14(4):483-489. Epub 2019 Feb 11.

Department of Radiology, Donnam Institute of Radiological and Medical Science, 40, Jwadong-gil, Jangan-eup, Gijang-gun, Busan 46033, Republic of Korea.

Squamous cell carcinoma (SCC) of the prostate is a rare tumor with aggressive nature. This type of tumor has a poor response to conventional treatment and results in poor prognosis. Squamous differentiation or metaplasia may arise subsequent to endocrine or radiation treatment, but it is very rare. Read More

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http://dx.doi.org/10.1016/j.radcr.2019.01.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6374616PMC
April 2019
2 Reads

Genitourinary Tumors: Update on Molecular Biomarkers for Diagnosis, Prognosis and Prediction of Response to Therapy.

Curr Drug Metab 2019 Feb 25. Epub 2019 Feb 25.

Section of Pathological Anatomy, Polytechnic University of the Marche Region, School of Medicine, United Hospitals, Ancona. Italy.

Background: Research of biomarkers in genitourinary tumors goes along with development of complex emerging techniques ranging from next generation sequencing platforms, applied to archival pathology specimens, cytological samples, liquid biopsies, and to patient-derived tumor models.

Method: This contribution is an update on molecular biomarkers for diagnosis, prognosis and prediction of response to therapy in genitourinary tumors. The following major topics are dealt with: Immunological biomarkers, including the microbiome, and their potential role and caveats in renal cell carcinoma, bladder and prostate cancers and testicular germ cell tumors; Tissue biomarkers for imaging and therapy, with emphasis on Prostate-specific membrane antigen in prostate cancer; Liquid biomarkers in prostate cancer, including circulating tumor cell isolation and characterization in renal cell carcinoma, bladder cancer with emphasis on biomarkers detectable in the urine and testicular germ cell tumors; and Biomarkers and economic sustainability. Read More

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http://dx.doi.org/10.2174/1389200220666190225124352DOI Listing
February 2019
10 Reads

PET imaging in renal cancer.

Curr Opin Oncol 2019 May;31(3):216-221

Department of Nuclear Medicine & PET Centre, Aarhus University Hospital, Denmark.

Purpose Of Review: Worldwide, over 400 000 new cases of kidney cancer were diagnosed and over 175 000 deaths anticipated in 2018. It is ranked as the 14th most common cancer in women and 9th most common in men. Imaging is important for initial detection, staging, and monitoring to assist treatment planning, but conventional anatomic imaging is limited. Read More

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http://dx.doi.org/10.1097/CCO.0000000000000518DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6465137PMC
May 2019
16 Reads

Tumor-Specific S/G-Phase Cell Cycle Arrest of Cancer Cells by Methionine Restriction.

Methods Mol Biol 2019 ;1866:49-60

AntiCancer, Inc., San Diego, CA, USA.

Cancer cells require elevated amounts of methionine (MET) and arrest their growth under conditions of MET restriction (MR). This phenomenon is termed MET dependence. Fluorescence-activated cell sorting (FACS) first indicated that the MET-dependent SV40-transformed cancer cells were arrested in the S and G phases of the cell cycle when under MR. Read More

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http://link.springer.com/10.1007/978-1-4939-8796-2_5
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http://dx.doi.org/10.1007/978-1-4939-8796-2_5DOI Listing
January 2019
10 Reads

Differentiating intrapulmonary metastases from different primary tumors via quantitative dual-energy CT based iodine concentration and conventional CT attenuation.

Eur J Radiol 2019 Feb 14;111:6-13. Epub 2018 Dec 14.

Department of Diagnostic and Interventional Radiology, Klinikum rechts der Isar, Technical University of Munich, Germany.

Introduction: To investigate the utility of quantitative dual-energy spectral CT derived iodine concentration (IC), in comparison with conventional CT attenuation, for the differentiation of pulmonary metastases from different primary malignancies.

Materials And Methods: CT scans were performed on a dual-layer spectral CT. We retrospectively evaluated pulmonary metastases of 130 patients (77 men and 53 women, mean age 63, range 22-87) with primary bone (OS) (osteosarcoma; n = 6), breast (invasive-ductal adenocarcinoma; n = 17), colorectal (CRC) (adenocarcinoma; n = 27), head and neck (HNC) (squamous cell carcinoma; n = 17), kidney (RCC) (clear-cell renal cell carcinoma; n = 10), lung (adenocarcinoma; n = 12), pancreato-biliary (PBC) (adenocarcinoma; n = 18), prostate (adenocarcinoma; n = 5), soft tissue (undifferentiated pleomorphic sarcoma; n = 6), skin (malignant melanoma; n = 6), and urinary tract (transitional-cell carcinoma; n = 6) malignancies. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0720048X183045
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http://dx.doi.org/10.1016/j.ejrad.2018.12.015DOI Listing
February 2019
10 Reads

Trousseau syndrome in a patient with advanced oral squamous cell carcinoma: a case report.

J Med Case Rep 2019 Jan 29;13(1):26. Epub 2019 Jan 29.

Department of Oral and Maxillofacial Surgery, Tokai University School of Medicine, 143 Shimokasuya, Isehara, Kanagawa, 259-1193, Japan.

Background: Trousseau syndrome is known as a variant of cancer-associated thrombosis. Trousseau syndrome commonly occurs in patients with lung or prostate cancer. Hypercoagulability is thought to be initiated by mucins produced by the adenocarcinoma, which react with leukocyte and platelet selectins to form platelet-rich microthrombi. Read More

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http://dx.doi.org/10.1186/s13256-018-1833-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350311PMC
January 2019
4 Reads

Imaging of Prostate-Specific Membrane Antigen with Small-Molecule PET Radiotracers: From the Bench to Advanced Clinical Applications.

Annu Rev Med 2019 01;70:461-477

The Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA; email: ,

In recent years, small-molecule inhibitors of prostate-specific membrane antigen (PSMA) labeled with radionuclides that allow for positron emission tomography (PET) imaging have been extensively studied in many clinical contexts in men with prostate cancer (PCa). The high sensitivity and specificity of these agents for identifying sites of PCa has quickly led to their widespread adoption as a de facto clinical standard of care throughout much of the world. PSMA-targeted PET radiotracers have been particularly well-studied in preoperatively staging men with high-risk PCa, evaluating biochemical recurrence following definitive therapy, and guiding metastasis-directed therapy in patients suspected of having oligorecurrent/oligometastatic disease. Read More

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http://dx.doi.org/10.1146/annurev-med-062117-073027DOI Listing
January 2019
13 Reads

68Ga-PSMA-11 PET/MR Can Be False Positive in Normal Prostatic Tissue.

Clin Nucl Med 2019 04;44(4):e291-e293

Department of Nuclear Medicine, University Hospital Zürich, University of Zürich

Prostate-specific membrane antigen (PSMA) is a transmembrane glycoprotein expressed in the cytosol of normal prostate tissue and highly overexpressed on the membrane of prostate cancer, therefore increasingly used to image prostate cancer. We report a case of a 65-year-old man with two focal PSMA-positive areas on a Ga-PSMA-11 PET/MR, one corresponding to a prostate carcinoma (Gleason score 4 + 3) and another region without any evidence of malignancy, but with corresponding high PSMA-expression on immunohistochemistry. Read More

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http://dx.doi.org/10.1097/RLU.0000000000002473DOI Listing
April 2019
17 Reads

Molecular Hallmarks of Multiparametric Magnetic Resonance Imaging Visibility in Prostate Cancer.

Eur Urol 2019 Jan 24. Epub 2019 Jan 24.

Department of Urology, David Geffen School of Medicine, University of California, Los Angeles, CA, USA; Jonsson Comprehensive Cancer Center, David Geffen School of Medicine, University of California, Los Angeles, CA, USA; Institute of Urologic Oncology, University of California, Los Angeles, CA, USA; Department of Urology, David Geffen School of Medicine, 300 Stein Plaza, Los Angeles, CA 90095, USA. Electronic address:

Multiparametric magnetic resonance imaging (mpMRI) has transformed the management of localized prostate cancer by improving identification of clinically significant disease at diagnosis. Approximately 20% of primary prostate tumors are invisible to mpMRI, and we hypothesize that this invisibility reflects fundamental molecular properties of the tumor. We therefore profiled the genomes and transcriptomes of 40 International Society of Urological Pathology grade 2 tumors: 20 mpMRI-invisible (Prostate Imaging-Reporting and Data System [PI-RADS] v2 <3) and 20 mpMRI-visible (PI-RADS v2 5) tumors. Read More

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http://dx.doi.org/10.1016/j.eururo.2018.12.036DOI Listing
January 2019
2 Reads

Positive effect of Actinium 225-PSMA treatment on ECOG performance status: A case report on a patient with castration resistant stage IV prostate carcinoma.

Rev Esp Med Nucl Imagen Mol 2019 Jan 18. Epub 2019 Jan 18.

International Atomic Energy Agency, Nuclear Medicine and Diagnostic Imaging Section, Viena, Austria. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S2253654X183015
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http://dx.doi.org/10.1016/j.remn.2018.09.003DOI Listing
January 2019
9 Reads

Effectiveness of the combination of vascular targeted photodynamic therapy and anti-cytotoxic T-lymphocyte-associated antigen 4 in a preclinical mouse model of urothelial carcinoma.

Int J Urol 2019 Mar 18;26(3):414-422. Epub 2019 Jan 18.

Urology Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York City, New York, USA.

Objective: To investigate the effectiveness of combination treatment of vascular targeted photodynamic therapy and anti-cytotoxic T-lymphocyte-associated antigen 4 immunotherapy in a mouse model of urothelial carcinoma.

Methods: We used C57BL/6 mice injected with murine bladder 49 cell line. Mice were randomly allocated into four treatment groups: vascular targeted photodynamic therapy only, anti-cytotoxic T-lymphocyte-associated antigen 4 only, combination therapy and control. Read More

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http://doi.wiley.com/10.1111/iju.13878
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http://dx.doi.org/10.1111/iju.13878DOI Listing
March 2019
15 Reads

Basal cell carcinoma of the prostate: A case report and review of the literature.

Mol Clin Oncol 2019 Jan 30;10(1):101-104. Epub 2018 Oct 30.

Department of Urology, Nankai Medical Center, Saiki, Oita 876-0857, Japan.

Basal cell carcinoma (BCC) of the prostate is a rare tumor exhibiting various morphological characteristics, and its progression varies from an indolent to an aggressive type, with local recurrence or distant metastasis. We herein report the case of a patient who was diagnosed with early-stage BCC of the prostate and treated by surgery. A 68 year-old-man visited our hospital for a follow-up for bladder cancer. Read More

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http://dx.doi.org/10.3892/mco.2018.1754DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6313957PMC
January 2019
2 Reads

Primary urothelial carcinoma of the prostate: A rare case report.

Medicine (Baltimore) 2019 Jan;98(3):e14155

Department of Urology, The First Affiliated Hospital of Anhui Medical University.

Rationale: Prostatic urothelial carcinoma is a rare disease. Medical misdiagnosis rates remain high because there are no specific clinical symptoms or imaging features, which decreases patient survival. We report a case of prostatic urethral cancer confirmed by transrectal ultrasound-guided prostate biopsy because of an abnormal digital rectal exam. Read More

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http://dx.doi.org/10.1097/MD.0000000000014155DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6370032PMC
January 2019
3 Reads
5.723 Impact Factor

Current Trends in Cancer Nanotheranostics: Metallic, Polymeric, and Lipid-Based Systems.

Pharmaceutics 2019 Jan 8;11(1). Epub 2019 Jan 8.

iMedUlisboa, Faculty of Pharmacy, Universidade de Lisboa, Av. Prof. Gama Pinto, 1649-003 Lisboa, Portugal.

Theranostics has emerged in recent years to provide an efficient and safer alternative in cancer management. This review presents an updated description of nanotheranostic formulations under development for skin cancer (including melanoma), head and neck, thyroid, breast, gynecologic, prostate, and colon cancers, brain-related cancer, and hepatocellular carcinoma. With this focus, we appraised the clinical advantages and drawbacks of metallic, polymeric, and lipid-based nanosystems, such as low invasiveness, low toxicity to the surrounding healthy tissues, high precision, deeper tissue penetration, and dosage adjustment in a real-time setting. Read More

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http://dx.doi.org/10.3390/pharmaceutics11010022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6359642PMC
January 2019
2 Reads

A Review of Prostate-Specific Membrane Antigen (PSMA) Positron Emission Tomography (PET) in Renal Cell Carcinoma (RCC).

Mol Imaging Biol 2019 Jan 7. Epub 2019 Jan 7.

Faculty of Medicine, The University of Queensland, Brisbane, Queensland, Australia.

Metastatic renal cell carcinoma (mRCC) is a disease that portends poor prognosis despite an increasing number of novel systemic treatment options including new targeted therapies and immunotherapy. Ablative intervention directed at oligometastatic RCC has demonstrated survival benefit. Consequently, developing techniques for improved staging of mRCC on contemporary imaging modalities including X-ray computed tomography (CT), magnetic resonance imaging (MRI) and/or bone scan (BS) is a clinical priority. Read More

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http://dx.doi.org/10.1007/s11307-018-01307-0DOI Listing
January 2019
2 Reads

Overexpression of prostate specific membrane antigen by canine hemangiosarcoma cells provides opportunity for the molecular detection of disease burdens within hemorrhagic body cavity effusions.

PLoS One 2019 2;14(1):e0210297. Epub 2019 Jan 2.

Department of Veterinary Clinical Medicine, University of Illinois, Urbana, IL, United States of America.

Background: Canine hemangiosarcoma (cHSA) is a highly metastatic mesenchymal cancer that disseminates by hematogenous and direct implantation routes. Therapies for cHSA are generally ineffective, in part due to advanced clinical disease stage at the time of diagnosis. The validation of conventional molecular methods for detecting novel biomarkers preferentially expressed by cHSA could lead to more timely diagnosis, earlier therapeutic interventions, and improved outcomes. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0210297PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6314605PMC
January 2019
3 Reads

Clear cell papillary renal cell carcinoma: A case report and review of the literature.

World J Nephrol 2018 Dec;7(8):155-160

Department of Urology, Center for Prostate Cancer, National Cancer Center, Goyang 410-769, South Korea.

Clear cell papillary renal cell carcinoma (ccpRCC) was recently established as a distinct type of epithelial neoplasm by the International Society of Urological Pathology Vancouver Classification of Renal Neoplasia. Here, we report a case of partial nephrectomy for a ccpRCC detected during the routine follow-up of a previously treated liposarcoma in a 70-year-old male patient. The patient was referred to the urology department for a right-sided renal mass (size: 2 cm) detected during routine annual imaging follow-up for a malignant right inguinal fibrous histocytoma and liposarcoma that had been diagnosed 6 and 4 years earlier, respectively, and treated with surgery and adjuvant radiation therapy. Read More

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http://dx.doi.org/10.5527/wjn.v7.i8.155DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6305527PMC
December 2018
1 Read

18F-choline PET/CT incidental thyroid uptake in patients studied for prostate cancer.

Endocrine 2019 Mar 29;63(3):531-536. Epub 2018 Dec 29.

Nuclear Medicine, University of Brescia and Spedali Civili Brescia, Brescia, Italy.

Purpose: Thyroid incidental uptake is defined as a thyroid uptake incidentally detected by imaging examinations performed for non-thyroid disease. The aim of this study was to establish the prevalence and the pathological nature of focal thyroid incidental uptake (FTIU) among patients studied with 18F-choline-PET/CT.

Materials And Methods: We retrospectively evaluated 368 patients who performed 18F-choline-PET/CT between June 2016 and August 2018. Read More

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http://dx.doi.org/10.1007/s12020-018-01832-6DOI Listing
March 2019
6 Reads

18F-Fluciclovine PET/CT Detection of Recurrent Prostate Carcinoma in Patients With Serum PSA ≤ 1 ng/mL After Definitive Primary Treatment.

Clin Nucl Med 2019 Mar;44(3):e128-e132

From the Departments of Radiology, and.

Purpose: The aims of this study were to report on our initial experience using F-fluciclovine PET/CT to detect recurrent prostate carcinoma in patients with low serum prostate-specific antigen (PSA) after definitive treatment of primary disease and to conduct a preliminary investigation for factors associated with positive scan findings.

Patients And Methods: In this retrospective study, F-fluciclovine PET/CT scans from 28 men with suspected recurrence of prostate carcinoma and PSA values of 1 ng/mL or less were examined to identify the site(s) of disease recurrence. Differences in detection rate for Gleason scores of 7 and greater than 7, T2 and T3 disease, negative and positive surgical margins, and negative and positive seminal vesicle invasion were compared using the Fisher exact test. Read More

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http://dx.doi.org/10.1097/RLU.0000000000002432DOI Listing
March 2019
1 Read

Intraductal carcinoma of the prostate (IDC-P) lowers apparent diffusion coefficient (ADC) values among intermediate risk prostate cancers.

J Magn Reson Imaging 2018 Dec 25. Epub 2018 Dec 25.

Department of Medical Imaging, Ottawa Hospital, Ottawa, Ontario, Canada.

Background: Prostatic intraductal carcinoma (IDC-P) is an aggressive variant of prostate cancer (PCa) characterized by proliferation of malignant cells within prostatic ducts/acini and nucleomegaly.

Purpose/hypothesis: To compare apparent diffusion coefficient (ADC) values and Prostate Imaging and Data Reporting System (PI-RADS) v. 2 scores in intermediate risk (International Society of Urological Pathology [ISUP] Grade Group [GG] 2 and 3) PCa with/without IDC-P to determine if IDC-P alters the MRI appearance of PCa. Read More

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http://dx.doi.org/10.1002/jmri.26594DOI Listing
December 2018
12 Reads
3.210 Impact Factor

Comparing diagnostic accuracy of luminal water imaging with diffusion-weighted and dynamic contrast-enhanced MRI in prostate cancer: A quantitative MRI study.

NMR Biomed 2019 Feb 21;32(2):e4048. Epub 2018 Dec 21.

UBC MRI Research Center, Vancouver, BC, Canada.

Luminal water imaging (LWI) is a new MRI T mapping technique that has been developed with the aim of diagnosis of prostate carcinoma (PCa). This technique measures the fractional amount of luminal water in prostate tissue, and has shown promising preliminary results in detection of PCa. To include LWI in clinical settings, further investigation on the accuracy of this technique is required. Read More

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http://dx.doi.org/10.1002/nbm.4048DOI Listing
February 2019
1 Read

Prostate cancer laparoscopic port site metastasis: A case report.

Medicine (Baltimore) 2018 Dec;97(51):e13757

Introduction: Laparoscopic port site metastases are a rare but clinically important cause of biochemically recurrent prostate adenocarcinoma. C-11 choline, among other prostate-specific positron emission tomography (PET) radiotracers, has improved radiologist confidence in these otherwise difficult-to-detect sites of recurrence.

Patient Concerns: A 62-year-old male presented with biochemically recurrent prostate adenocarcinoma after undergoing robotic-assisted radical prostatectomy 5 years earlier. Read More

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http://dx.doi.org/10.1097/MD.0000000000013757DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6319866PMC
December 2018
3 Reads

Management of Older Patients With Metastatic Renal Cell Carcinoma Receiving Sunitinib: A Hypothetical, Illustrative Case Scenario.

J Adv Pract Oncol 2018 Jan-Feb;9(1):67-76. Epub 2018 Jan 1.

Duke Prostate Center, Durham, North Carolina.

Tom, a 75-year-old white male, was recently diagnosed with metastatic renal cell carcinoma (RCC; Tom's case is not an actual clinical case but has been developed by the authors as an exemplar). Two years prior, he had undergone a left partial (laparoscopic) nephrectomy for clear cell RCC. At that time, he had a stage 3 disease (the tumor extended into perinephric tissues but not into the ipsilateral adrenal gland and not beyond Gerota's fascia [Cancer. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6296420PMC
January 2018
3 Reads

Direct comparison of choline PET/CT and MRI in the diagnosis of lymph node metastases in patients with prostate cancer.

Medicine (Baltimore) 2018 Dec;97(50):e13344

Department of Nuclear Medicine, Pingjin Hospital, Characteristic Medical Center of Chinese People's Armed Police Forces, Tianjin, China.

Background: Lymph node detection in prostate cancer is challenging and critical to determine treatment policy. Choline PET/CT (positron emission tomography/computed tomography) and magnetic resonance imaging (MRI) have been used for the evaluation of lymph node metastasis in patients with prostate cancer for the past decade. However, only limited patients underwent direct comparison studies. Read More

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http://dx.doi.org/10.1097/MD.0000000000013344DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6320103PMC
December 2018
5.723 Impact Factor

Prostate Cancer Genomic Classifier Relates More Strongly to Gleason Grade Group Than Prostate Imaging Reporting and Data System Score in Multiparametric Prostate Magnetic Resonance Imaging-ultrasound Fusion Targeted Biopsies.

Urology 2019 Mar 12;125:64-72. Epub 2018 Dec 12.

Department of Urology, Yale School of Medicine, New Haven, CT. Electronic address:

Objective: To assess the association between Prostate Imaging Reporting and Data System version 2 (PI-RADSv2) score, the Decipher score, and histologic grade of carcinoma in biopsy tissue among low- to intermediate-risk prostate cancer patients.

Methods: MRI-ultrasound targeted biopsy of regions of interest and concurrent 12-core systematic biopsy was performed on men with Gleason grade group (GG) 1 and 2. We compared Decipher score with PI-RADS scores and biopsy Gleason GG. Read More

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http://dx.doi.org/10.1016/j.urology.2018.12.001DOI Listing
March 2019
1 Read

Synthesis and SAR of novel capsazepine analogs with significant anti-cancer effects in multiple cancer types.

Bioorg Med Chem 2019 Jan 29;27(1):208-215. Epub 2018 Nov 29.

Department of Comprehensive Dentistry, University of Texas Health Science Center at San Antonio School of Dentistry, San Antonio, Texas 78229, USA; Mays Cancer Center, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229, USA. Electronic address:

We previously demonstrated that capsazepine (CPZ), a synthetic transient receptor potential Vanilloid subtype 1 (TRPV1) antagonist, has significant anti-cancer effects in vivo. The purpose of this study was to develop more potent analogs based upon CPZ pharmacophore and structure-activity relationships (SAR) across analogs. We generated 30 novel compounds and screened for their anti-proliferative effects in cultured HeLa cervical cancer cells. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09680896183133
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http://dx.doi.org/10.1016/j.bmc.2018.11.040DOI Listing
January 2019
2 Reads
2.793 Impact Factor

Advances in Prostatic Diagnostics in Dogs: The Role of Canine Prostatic Specific Esterase in the Early Diagnosis of Prostatic Disorders.

Top Companion Anim Med 2018 Dec 8;33(4):105-108. Epub 2018 Sep 8.

Dipartimento di Medicina Veterinaria (DiMeV), Section of Surgery and Obstetrics, University of Bari Aldo Moro, Italy. Electronic address:

In last years, following the increased canine life expectancy and the rising attention pet-owners devote to their animals, several authors have carried on investigations concerning new techniques to early identify canine prostatic disorders that might affect the dog's quality of life. Prostatic disorders often have an asymptomatic onset and their early diagnosis is difficult: hence, they are usually identified at an advanced stage, only. Traditionally, the diagnosis of prostatic disorders is based on noninvasive tools, such as transrectal and abdominal palpation, seminal or prostatic fluid evaluation, and urinalysis and imaging. Read More

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http://dx.doi.org/10.1053/j.tcam.2018.09.002DOI Listing
December 2018
2 Reads

Coexistence of neurofibromatosis type 1 with multiple malignant neoplasia.

Neuro Endocrinol Lett 2018 Sep;39(3):149-155

Clinical Department of Endocrinology, Jagiellonian University in Krakow, Poland.

Neurofibromatosis type 1 (NF1, von Recklinghausen disease) is inherited in autosomal dominant way genetic disorder, with an incidence at birth 1:3000. It is one of the most common congenital disorders. It is characterized by café-au-lait spots, neurofibromas, and less common MPTST and gliomas of the optic nerve. Read More

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September 2018
21 Reads

Phase I study of a new tablet-based image guided surgical system in robot-assisted radical prostatectomy.

Minerva Urol Nefrol 2019 Feb 7;71(1):92-95. Epub 2018 Nov 7.

Department of Urology, Guy's Hospital, London, UK.

Robot-assisted radical prostatectomy is, currently, the most commonly utilized procedure for the treatment of localized prostate cancer. Image-guided surgical systems have been proposed in the literature as a valuable tool for the better utilization of the preoperative data in theatre. In this Phase 1 trial, we tested the feasibility and safety of a new, cutting-edge tablet-based surgical imaging system designed for robot-assisted radical prostatectomy (RARP). Read More

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https://www.minervamedica.it/index2.php?show=R19Y9999N00A181
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http://dx.doi.org/10.23736/S0393-2249.18.03250-2DOI Listing
February 2019
22 Reads
0.700 Impact Factor

Comparison of biparametric MRI to full multiparametric MRI for detection of clinically significant prostate cancer.

Prostate Cancer Prostatic Dis 2018 Nov 9. Epub 2018 Nov 9.

Department of Urology, University of Alabama at Birmingham, Birmingham, AL, USA.

Background: Multiparametric magnetic resonance imaging (MP-MRI) and MRI/ultrasound (US) fusion-guided biopsy are becoming more widely used techniques for prostate cancer (PCa) diagnosis and management. However, their widespread adoption and use, where available, are limited by cost and added time. These limitations could be minimized if a biparametric MRI (BP-MRI) focusing on T2-weighted and diffusion-weighted imaging is performed. Read More

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http://www.nature.com/articles/s41391-018-0107-0
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http://dx.doi.org/10.1038/s41391-018-0107-0DOI Listing
November 2018
8 Reads

Images in two prostate cancer patients of second primary cancers: Hodgkin's lymphoma and lung adenocarcinoma.

Hell J Nucl Med 2018 Sep-Dec;21(3):221-223. Epub 2018 Nov 10.

Nuclear Medicine Department, Greater Poland Cancer Centre, Garbary 15 Street, 60-101 Poznan, Poland.

Hodgkin's lymphoma and lung adenocarcinoma as second primary cancers in prostate cancer (PC) patients although are rare should be considered as important for the future of the PC patients. Read More

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http://dx.doi.org/10.1967/s002449910908DOI Listing
February 2019
1 Read

Comparison of hock- and footpad-injection as a prostate adenocarcinoma model in rats.

BMC Vet Res 2018 Nov 6;14(1):327. Epub 2018 Nov 6.

Clinic of Diagnostic Imaging, Vetsuisse Faculty, University of Zurich, Winterthurerstrasse 260, 8057, Zurich, Switzerland.

Background: Objective of this study is a feasibility-test comparing hock- and footpad-injection in rats with inoculated MatLyLu - adenocarcinoma tumor model. This study compares the development of an adenocarcinoma model (MatLyLu) in 12 Copenhagen rats. Two groups (n = 6) of animals were inoculated with 1 × 10 MatLyLu tumor cells solved in 0. Read More

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http://dx.doi.org/10.1186/s12917-018-1659-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6219108PMC
November 2018

Computed tomography and magnetic resonance imaging findings of metastatic rectal linitis plastica from prostate cancer: A case report and review of literature.

World J Clin Cases 2018 Oct;6(12):554-558

Department of Surgery, Chonbuk National University Medical School and Hospital, Jeonju 54907, Chonbuk, South Korea.

Linitis plastica is a rare condition showing circumferentially infiltrating intramural anaplastic carcinoma in a hollow viscus, resulting in a tissue thickening of the involved organ as constricted, inelastic, and rigid. While most secondary rectal linitis plastica (RLP) is caused by metastasis from stomach, breast, gallbladder, or bladder cancer, we report an extremely rare and unique case of secondary RLP due to prostate cancer with computed tomography (CT) and magnetic resonance imaging (MRI) findings, including diffusion weighted imaging (DWI). A 78-year-old man presented with approximately a 2-mo history of constipation and without cancer history. Read More

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http://www.wjgnet.com/2307-8960/full/v6/i12/554.htm
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http://dx.doi.org/10.12998/wjcc.v6.i12.554DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6212608PMC
October 2018
12 Reads

Discovery of F-JK-PSMA-7, a novel PET-probe for the detection of small PSMA positive lesions.

J Nucl Med 2018 Nov 2. Epub 2018 Nov 2.

University Hospital of Cologne, Germany.

Prostate specific membrane antigen (PSMA) expressed by the vast majority of prostate cancers (PCa) is a promising target for PCa imaging. The application of PSMA specific F-labeled PET probes like F-DCFPyL and F-PSMA-1007 considerably improved the accuracy of PCa tumor detection. However, there remains a need for further improvements regarding sensitivity and specificity. Read More

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http://jnm.snmjournals.org/lookup/doi/10.2967/jnumed.118.218
Publisher Site
http://dx.doi.org/10.2967/jnumed.118.218495DOI Listing
November 2018
18 Reads
6.160 Impact Factor