4,407 results match your criteria Imaging in Prostate Carcinoma

Special issue "The advance of solid tumor research in China": 68Ga-PSMA-11 PET/CT for evaluating primary and metastatic lesions in different histological subtypes of renal cell carcinoma.

Int J Cancer 2022 Jun 25. Epub 2022 Jun 25.

Department of Urology, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, 651 Dongfeng Road East, Guangzhou, People's Republic of China.

Conventional imaging examinations are not sensitive enough for the early detection of recurrent or metastatic lesions in renal cell carcinoma (RCC) patients. We aimed to explore the role of Ga- prostate specific membrane antigen (PSMA)-11 positron emission tomography (PET)/computed tomography (CT) in the detection of primary and metastatic lesions in such patients. We retrospectively analyzed 50 RCC patients who underwent Ga-PSMA-11 PET/CT from November 2017 to December 2020. Read More

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A Small Molecule That Promotes Cellular Senescence Prevents Fibrogenesis and Tumorigenesis.

Int J Mol Sci 2022 Jun 20;23(12). Epub 2022 Jun 20.

Osteoneurogen. Inc., Seoul 08501, Korea.

Uncontrolled proliferative diseases, such as fibrosis or cancer, can be fatal. We previously found that a compound containing the chromone scaffold (CS), ONG41008, had potent antifibrogenic effects associated with EMT or cell-cycle control resembling tumorigenesis. We investigated the effects of ONG41008 on tumor cells and compared these effects with those in pathogenic myofibroblasts. Read More

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Systemic Ablation of Impairs Metastatic Colonization and Improves Insulin Sensitivity in TRAMP Mice: Evidence for Cancer Cell-Extrinsic CAMKK2 Functions in Prostate Cancer.

Cells 2022 06 10;11(12). Epub 2022 Jun 10.

Department of Cancer Systems Imaging, The University of Texas MD Anderson Cancer Center, Houston, TX 77054, USA.

Despite early studies linking calcium-calmodulin protein kinase kinase 2 (CAMKK2) to prostate cancer cell migration and invasion, the role of CAMKK2 in metastasis in vivo remains unclear. Moreover, while CAMKK2 is known to regulate systemic metabolism, whether CAMKK2's effects on whole-body metabolism would impact prostate cancer progression and/or related comorbidities is not known. Here, we demonstrate that germline ablation of slows, but does not stop, primary prostate tumorigenesis in the TRansgenic Adenocarcinoma Mouse Prostate (TRAMP) genetic mouse model. Read More

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PET-CT in Clinical Adult Oncology-IV. Gynecologic and Genitourinary Malignancies.

Cancers (Basel) 2022 Jun 18;14(12). Epub 2022 Jun 18.

Department of Radiology and Imaging Sciences, University of Utah, Salt Lake City, UT 84132, USA.

Concurrently acquired positron emission tomography and computed tomography (PET-CT) is an advanced imaging modality with diverse oncologic applications, including staging, therapeutic assessment, restaging and longitudinal surveillance. This series of six review articles focuses on providing practical information to providers and imaging professionals regarding the best use and interpretative strategies of PET-CT for oncologic indications in adult patients. In this fourth article of the series, the more common gynecological and adult genitourinary malignancies encountered in clinical practice are addressed, with an emphasis on Food and Drug Administration (FDA)-approved and clinically available radiopharmaceuticals. Read More

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Urothelial carcinoma of the prostate with raised β-hCG levels: a case report.

J Med Case Rep 2022 Jun 15;16(1):238. Epub 2022 Jun 15.

Department of Pathology, Chair of Oncology, Medical University of Lodz, ul. Pomorska 251, 90-001, Lodz, Poland.

Background: Trophoblastic differentiation in primary urothelial carcinoma of the prostate is extremely rare. An increased level of β-subunit human chorionic gonadotropin in serum in urothelial carcinoma is detected in approximately 30% of cases. To our knowledge, increased concentration of β-subunit human chorionic gonadotropin in serum in prostatic urothelial carcinoma has never been reported and its clinical significance is not evaluated yet. Read More

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Label-free optical redox ratio from urinary extracellular vesicles as a screening biomarker for bladder cancer.

Am J Cancer Res 2022 15;12(5):2068-2083. Epub 2022 May 15.

Department of Bioengineering, University of Illinois at Urbana-Champaign IL, USA.

Extracellular vesicles (EVs) have been studied for their potential applications in cancer screening, diagnosis, and treatment monitoring. Most studies have focused on the bulk content of EVs; however, it is also informative to investigate their metabolic status, and changes under different physiological and environmental conditions. In this study, noninvasive, multimodal, label-free nonlinear optical microscopy was used to evaluate the optical redox ratio of large EVs (microvesicles) isolated from the urine of 11 dogs in three cohorts (4 healthy, 4 transitional cell carcinoma (TCC) of the bladder, and 3 prostate cancer). Read More

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Imaging response assessment for oncology: An algorithmic approach.

Eur J Radiol Open 2022 7;9:100426. Epub 2022 Jun 7.

Tufts University School of Medicine, United States.

Treatment response assessment by imaging plays a vital role in evaluating changes in solid tumors during oncology therapeutic clinical trials. Response Evaluation Criteria in Solid Tumors (RECIST) 1.1 is the reference standard imaging response criteria and provides details regarding image acquisition, image interpretation and categorical response classification. Read More

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Dosimetric comparison of analytical anisotropic algorithm and the two dose reporting modes of Acuros XB dose calculation algorithm in volumetric modulated arc therapy of carcinoma lung and carcinoma prostate.

Med Dosim 2022 Jun 8. Epub 2022 Jun 8.

SUT Royal Hospital, Ulloor, Thiruvananthapuram, Kerala 695011, India.

Volumetric Modulated Arc Therapy (VMAT) is an important modality for radical radiotherapy of all major treatment sites. This study aims to compare Analytical Anisotropic Algorithm (AAA) and the two dose-reporting modes of Acuros XB (AXB) algorithm -the dose to medium option (D) and the dose to water option (D) in Volumetric Modulated Arc Therapy (VMAT) of carcinoma lung and carcinoma prostate. We also compared the measured dose with Treatment Planning System calculated dose for AAA and the two dose reporting options of Acuros XB using Electronic Portal Imaging Device (EPID) and ArcCHECK phantom. Read More

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Incremental Value of 18F-PSMA-1007 PET/CT in Detection of Metastatic Renal Cell Carcinoma to the Brain.

Clin Nucl Med 2022 Jul 27;47(7):627-628. Epub 2022 Apr 27.

From the Department of Nuclear Medicine, Jaber Al Ahmed Center of Molecular Imaging.

Abstract: 18F-PSMA PET/CT is an emerging standard of care in staging prostate cancer, evaluating biochemical recurrence and response to therapy. Despite the nomenclature, PSMA expression is also documented at the tumor-associated neovasculature of other malignant solid tumors including renal cell carcinoma. We report a case of 44-year-old man known to have renal cell carcinoma who underwent 18F-PSMA and 18F-FDG PET/CT for restaging after radical nephrectomy. Read More

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Minimally Invasive Procedures in the Diagnosis and Treatment of Localized Prostate Cancer: an Interventional Radiologist's Perspective.

Curr Oncol Rep 2022 Jun 7. Epub 2022 Jun 7.

Department of Medical Imaging, Radboud University Nijmegen Medical Centre, Geert Grooteplein 10, 6525 GA, Nijmegen, Gelderland, The Netherlands.

Purpose Of Review: Minimal invasive procedures, including targeted biopsy (TB) and focal therapy (FT), are increasingly used in diagnosis and treatment of localized prostate cancer. Here, we review the current role of these procedures, from a perspective of an interventional radiologist.

Recent Findings: TB is an established part of current guidelines for diagnosis of PCa. Read More

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Role of tumor infiltrating lymphocytes and spatial immune heterogeneity in sensitivity to PD-1 axis blockers in non-small cell lung cancer.

J Immunother Cancer 2022 Jun;10(6)

Department of Pathology and Yale Cancer Center, Yale School of Medicine, New Haven, Connecticut, USA

Background: Tumor infiltrating lymphocytes (TILs) reflect adaptive antitumor immune responses in cancer and are generally associated with favorable prognosis. However, the relationships between TILs subsets and their spatial arrangement with clinical benefit from immune checkpoint inhibitors (ICI) in non-small cell lung cancer (NSCLC) remains less explored.

Methods: We used multiplexed quantitative immunofluorescence panels to determine the association of major TILs subpopulations, CD8 cytotoxic T cells, CD4 helper T cells and CD20 B cells, and T cell exhaustion markers, programmed cell death protein-1 (PD-1),lymphocyte-activation gene 3 (LAG-3) and T cell immunoglobulin mucin-3 (TIM-3) with outcomes in a multi-institutional cohort of baseline tumor samples from 179 patients with NSCLC treated with ICI. Read More

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T cell therapy against cancer: A predictive diffuse-interface mathematical model informed by pre-clinical studies.

J Theor Biol 2022 Aug 26;547:111172. Epub 2022 May 26.

MOX Laboratory, Department of Mathematics, Politecnico di Milano, Piazza Leonardo da Vinci 32, 20133 Milano, Italy. Electronic address:

T cell therapy has become a new therapeutic opportunity against solid cancers. Predicting T cell behaviour and efficacy would help therapy optimization and clinical implementation. In this work, we model responsiveness of mouse prostate adenocarcinoma to T cell-based therapies. Read More

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Detection rates of urogenital cancers and benign pathology in men presenting with hematospermia.

Curr Urol 2022 Mar 28;16(1):44-49. Epub 2022 Jan 28.

Department of Urology, Institute of Andrology, University College London Hospitals NHS Trust, London, UK.

Background: Hematospermia, although often found to be a benign condition, can be an alarming sign. Consequently, patients can undergo multiple investigations with no current standardized pathway based on data from large series. The aim of this study was to evaluate the incidence of an underlying pathology and the value of diagnostic investigations performed in patients presenting with hematospermia. Read More

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Incidental Detection of Radiotracer Uptake in Spindle Cell Lipoma on 18F-PSMA PET/CT.

Clin Nucl Med 2022 May 27. Epub 2022 May 27.

From the Institute of Nuclear Medicine and Molecular Imaging and the.

Abstract: An 84-year-old man underwent 18F-prostate-specific membrane antigen (PSMA) PET/CT for staging of a newly diagnosed prostate adenocarcinoma. PET/CT revealed high 18F-PSMA uptake in a thigh mass, which was initially suspected for a metastasis. Histopathology revealed a rare entity of spindle cell lipoma, which should be added to the reported list of neoplasms that can show "false-positive" PSMA uptake during evaluation of patients with prostate carcinoma representing a potential interpretative pitfall. Read More

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Breast cancers originating from the major lactiferous ducts and the process of neoductgenesis: Ductal Adenocarcinoma of the Breast, DAB.

Eur J Radiol 2022 Aug 18;153:110363. Epub 2022 May 18.

Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, 17 Hsuchow Road, Taipei 100, Taiwan.

Purpose: To call attention to a highly fatal breast cancer subtype arising from the major lactiferous ducts that is currently underdiagnosed as ductal carcinoma in situ (DCIS) with or without microinvasion.

Method: All breast cancers diagnosed at the Department of Mammography, Falun Central Hospital, Sweden, since 1977 have been classified according to their mammographic tumour features (imaging biomarkers) and followed up at regular intervals for the past four decades. The imaging biomarkers characteristic of breast cancers apparently arising from the major lactiferous ducts have been correlated with large format thin and thick section histopathology and long-term patient outcome. Read More

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Impact of measurement method on interobserver variability of apparent diffusion coefficient of lesions in prostate MRI.

PLoS One 2022 23;17(5):e0268829. Epub 2022 May 23.

Department of Radiology, Mayo Clinic, Rochester, Minnesota, United States of America.

Purpose: To compare the inter-observer variability of apparent diffusion coefficient (ADC) values of prostate lesions measured by 2D-region of interest (ROI) with and without specific measurement instruction.

Methods: Forty lesions in 40 patients who underwent prostate MR followed by targeted prostate biopsy were evaluated. A multi-reader study (10 readers) was performed to assess the agreement of ADC values between 2D-ROI without specific instruction and 2D-ROI with specific instruction to place a 9-pixel size 2D-ROI covering the lowest ADC area. Read More

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Adenoid cystic carcinoma of sinonasal origin masquerading as an intraconal lesion.

BMJ Case Rep 2022 May 13;15(5). Epub 2022 May 13.

Radiodiagnosis, Datta Meghe Institute of Medical Sciences - Wardha Campus, Wardha, Maharashtra, India.

Adenoid cystic carcinoma is an uncommon tumour of the salivary glands, although affliction of mucin-producing glands present in the oral cavity, oropharynx and paranasal sinuses is not uncommon. Other possible sites are lacrimal, oesophagus, trachea-bronchial tree, lungs, uterus, cervix, prostate. These tumours have a tendency to be aggressive and most show invasion into the adjacent region. Read More

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Functional, Aromatic, and Fluorinated Monothiosemicarbazones: Investigations into Their Structures and Activity toward the Gallium-68 Incorporation by Microwave Irradiation.

ACS Omega 2022 Apr 11;7(16):13750-13777. Epub 2022 Apr 11.

Department of Chemistry, University of Bath, Claverton Down, Bath BA2 7AY, United Kingdom.

We report on the synthesis and spectroscopic characterization of a new series of coordinating monothiosemicarbazones incorporating aromatic backbones, featuring O/N/S donor centers monosubstituted with different aliphatic, aromatic, fluorinated, and amine-functionalized groups at their N centers. Their ability to bind metal ions such as Zn(II) and Ga(III) was explored, and the formation of two different coordination isomers of the Zn(II) complex was demonstrated by X-ray diffraction studies using synchrotron radiation. These studies showed the planar geometry for the coordinated mono(thiosemicarbazone) ligand and that the metal center can adopt either a heavily distorted tetrahedral Zn center (placed in an N/S/S/N environment, with CN = 4) or a pseudo-octahedral geometry, where the Zn(II) center is in the O/N/S/S/N/O environment, and CN = 6. Read More

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A glance at the emerging diagnostic biomarkers in the most prevalent genitourinary cancers.

Saudi J Biol Sci 2022 Apr 15;29(4):2072-2084. Epub 2022 Jan 15.

Department of Clinical Laboratory Sciences, Faculty of Applied Medical Sciences, Najran University, 1988, Najran 61441, Saudi Arabia.

Genitourinary cancers comprise of a heterogenous group of cancers of which renal cell carcinoma, urothelial bladder carcinoma, and prostate adenocarcinoma are the most commonly encountered subtypes. A lot of research is ongoing using various strategies for exploration of novel biomarkers for genitourinary cancers. These biomarkers would not reduce the need for invasive diagnostic techniques but also could be used for early and accurate diagnosis to improve the clinical management required for the disease. Read More

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Painless penile periurethral polymicrobial abscess causing urinary retention.

Urol Case Rep 2022 May 1;42:102037. Epub 2022 Mar 1.

Faculty of Medicine, The University of Queensland, Brisbane, Queensland, Australia.

In contemporary urological practice periurethral abscesses are rare. We report the case of a 61-year-old presenting with a painless penile mass and urinary retention. He underwent imaging with ultrasonography, targeted antibiotics and successful source control through open incision and drainage. Read More

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Adenoid cystic carcinoma of the prostate - A rare case of genitourinary malignancy.

Urol Case Rep 2022 May 5;42:102025. Epub 2022 Feb 5.

Dept. of Urology, University Hospital Waterford, Dunmore Road, Waterford, X91 ER8E, Ireland.

A 72 year old was referred to the Urology department with lower urinary tract symptoms (LUTS), an abnormal prostate on digital examination and a serum prostate specific antigen (PSA) level within normal limits. A flexible cystoscopy revealed no abnormality of the urethra and an obstructive prostate. Magnetic resonance imaging (MRI) revealed a 4. Read More

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Leveraging artificial intelligence to predict ERG gene fusion status in prostate cancer.

BMC Cancer 2022 May 5;22(1):494. Epub 2022 May 5.

Department of Pathology, University of Michigan Medical School, Ann Arbor, MI, USA.

Background: TMPRSS2-ERG gene rearrangement, the most common E26 transformation specific (ETS) gene fusion within prostate cancer, is known to contribute to the pathogenesis of this disease and carries diagnostic annotations for prostate cancer patients clinically. The ERG rearrangement status in prostatic adenocarcinoma currently cannot be reliably identified from histologic features on H&E-stained slides alone and hence requires ancillary studies such as immunohistochemistry (IHC), fluorescent in situ hybridization (FISH) or next generation sequencing (NGS) for identification.

Methods: OBJECTIVE: We accordingly sought to develop a deep learning-based algorithm to identify ERG rearrangement status in prostatic adenocarcinoma based on digitized slides of H&E morphology alone. Read More

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Clinically undetected plasmacytoid urothelial carcinoma of the urinary bladder with non-mass-forming metastases in multiple organs: an autopsy case.

J Pathol Transl Med 2022 May 3. Epub 2022 May 3.

Department of Pathology and Laboratory Medicine, National Defense Medical College, Saitama, Japan.

This case report outlines a clinically undetected urinary bladder plasmacytoid urothelial carcinoma (PUC) with multiple metastases detected at autopsy. An 89-year-old man presented with edema in the lower limbs. Pleural fluid cytology revealed discohesive carcinomatous cells, although imaging studies failed to identify the primary site of tumor. Read More

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F DCFPyL PSMA avid biopsy proven subcutaneous capillary haemangioma as a malignancy mimic in the setting of biochemical recurrent prostate carcinoma.

Radiol Case Rep 2022 Jun 19;17(6):2211-2214. Epub 2022 Apr 19.

School of Medicine, University of Queensland, Herston, QLD 4006 Australia.

We present a case of a 65-year-old male with a biopsy proven subcutaneous capillary haemangioma identified on imaging for evaluation of further metastatic spread of prostatic carcinoma due to a rise in his prostate-specific antigen biochemistry. He was receiving salvage radiation therapy for his known isolated nodal disease, four years after prostatectomy. An intensely avid prostate-specific membrane antigen positron emission tomography-computed tomography lesion in the left paramedian back at the level of L1 was noted on his scan. Read More

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Characterization of tumor thrombus in renal cell carcinoma with prostate specific membrane antigen (PSMA) positron emission tomography (PET)/computed tomography (CT).

Urol Oncol 2022 06 22;40(6):276.e1-276.e9. Epub 2022 Apr 22.

Department of Urology, Royal Brisbane and Women's Hospital, Brisbane, Queensland, Australia; Faculty of Medicine, The University of Queensland, Brisbane, Queensland, Australia; Department of Urology, Redcliffe Hospital, Queensland, Australia; Centre for Clinical Research, The University of Queensland, Brisbane, QLD, Australia. Electronic address:

Introduction: Venous tumor thrombus (TT) occurs as part of the natural history of renal cell carcinoma (RCC) local progression in a small minority of cases. MRI is currently the most accurate imaging modality for determining TT extent. PSMA PET/CT may improve RCC staging and IVC TT characterization. Read More

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Recent Advances in Cancer Imaging with CuCl PET/CT.

Fangyu Peng

Nucl Med Mol Imaging 2022 Apr 17;56(2):80-85. Epub 2022 Feb 17.

Department of Radiology, UT Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390-9140 USA.

is required for cancer cell proliferation and tumor angiogenesis. Radioactive copper-64 chloride (CuCl) is a useful radiotracer for cancer imaging with position emission tomography (PET) based on increased cellular uptake of copper mediated by human copper transporter 1 (hCtr1) expressed on cancer cell membrane. Significant progress has been made in research of using CuCl as a radiotracer for cancer imaging with PET. Read More

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Primary squamous cell carcinoma of the testis: a rare presentation.

BMJ Case Rep 2022 Apr 22;15(4). Epub 2022 Apr 22.

Medical Oncology, Mount Vernon Cancer Centre, Northwood, UK

A man in his mid-70s presented with a lump in his left testicle. He had previously been treated for prostate cancer with radical radiotherapy. He was on treatment for hypertension and type 2 diabetes. Read More

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Eccrine Carcinoma With an Unknown Primary: Managing Occult Cancer Through Multidisciplinary Tumor Board Collaboration.

Cureus 2022 Mar 15;14(3):e23183. Epub 2022 Mar 15.

Radiation Oncology, Mount Auburn Hospital, Harvard Medical School, Cambridge, USA.

Eccrine carcinomas are rare cutaneous cancers that tend to be locally aggressive. Here we report a rare case of a mucinous eccrine carcinoma presenting in axillary lymph nodes without an identifiable primary lesion. This is a 69-year-old male with a past medical history of benign prostatic hyperplasia, melanoma, basal cell carcinoma, hypercholesterolemia, hypertension, and arthritis who was found to have an elevated prostate-specific antigen. Read More

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