Search Our Scientific Publications & Authors

Respiration 2021 Jun 24:1-9. Epub 2021 Jun 24.

Department of Pulmonary Diseases, Radboud University Medical Center, Nijmegen, The Netherlands.

Background: Endoscopic ultrasound routinely guides lymph node evaluation for the staging of a known or suspected lung cancer. Characteristics seen on B-mode imaging might help the observer decide on the lymph nodes of risk. The influence of nodal size on the predictivity of these characteristics and the agreement with which operators can combine these for malignancy risk prediction is to be determined. Read More

Phys Med Biol 2021 Jun 24. Epub 2021 Jun 24.

University of California Berkeley, Berkeley, 94720, UNITED STATES.

Cardiac CEST-MRI has been used to probe levels of various metabolites that provide insight into myocardial structure and function. However, imaging of the heart using CEST-MRI is prolonged by the need to repeatedly acquire multiple images for a full Z-spectrum and to perform saturation and acquisition around cardiac and respiratory cycles. Compressed sensing reconstruction of sparse data enables accelerated acquisition, reconstruction artifacts may bias subsequently derived measures of CEST contrast. Read More

J Phys Condens Matter 2021 Jun 24. Epub 2021 Jun 24.

Physics Department, Carl von Ossietzky Universitat Oldenburg, Carl-von-Ossietzky-Straße 9, Oldenburg, Niedersachsen, 26129 , GERMANY.

In the search for novel materials for vacuum electron sources, multi-alkali antimonides and in particular sodium-potassium-antimonides have been recently regarded as especially promising due to their favorable electronic and optical properties. In the framework of density-functional theory and many-body perturbation theory, we investigate the electronic structure and the dielectric response of two representative members of this family, namely NaKSb and NaKSb. We find that both materials have a direct gap, which is on the order of 1. Read More

J Phys Condens Matter 2021 Jun 24. Epub 2021 Jun 24.

Department of Medical Physics and Bioengineering, University College London, Malet Place Engineering Building, Malet Place, off Torrington Place, London, WC1E 6BT, London, WC1E 6BT, UNITED KINGDOM OF GREAT BRITAIN AND NORTHERN IRELAND.

Although early demonstration dates back to the mid-sixties, x-ray phase-contrast imaging (XPCI) became hugely popular in the mid-90s, thanks to the advent of 3rd generation synchrotron facilities. Its ability to reveal object features that had so far been considered invisible to x-rays immediately suggested great potential for applications across the life and the physical sciences, and an increasing number of groups worldwide started experimenting with it. At that time, it looked like a synchrotron facility was strictly necessary to perform XPCI with some degree of efficiency - the only alternative being micro-focal sources, the limited flux of which imposed excessively long exposure times. Read More

Physiol Meas 2021 Jun 24. Epub 2021 Jun 24.

Medical Information Technology, RWTH Aachen University, Aachen, Nordrhein-Westfalen, GERMANY.

Objective: Electrical impedance tomography (EIT) for lung perfusion imaging is attracting considerable interest in intensive care, as it might open up entirely new ways to adjust ventilation therapy. A promising technique is bolus injection of a conductive indicator to the central venous catheter, which yields the indicator-based signal (IBS). Lung perfusion images are then typically obtained from the IBS using the maximum slope technique. Read More

Phys Med Biol 2021 Jun 24. Epub 2021 Jun 24.

Electrical Engineering, Universidad Autónoma Metropolitana Iztapalapa, Iztapalapa, 09340, MEXICO.

Alzheimer's disease is a multifactorial neurodegenerative disorder preceded by a prodromal stage called mild cognitive impairment (MCI). Early diagnosis of MCI is crucial for delaying the progression and optimizing the treatment. In this study we propose a random forest (RF) classifier to distinguish between MCI and healthy control subjects (HC), identifying the most relevant features computed from structural T1-weighted and diffusion-weighted magnetic resonance images (sMRI and DWI), combined with neuro-psychological scores. Read More

J Sport Rehabil 2021 Jun 24:1-4. Epub 2021 Jun 24.

Context: Quantifying early posttraumatic ankle osteoarthritis pathogenesis using compositional magnetic resonance (MR) imaging sequences is becoming more common. These MR sequences are often manually segmented to isolate the cartilage of interest before cartilage compositional values (eg, T1ρ or T2) are quantified. However, limited information is available regarding the reliability and reproducibility of manual segmentation for the entire talar dome. Read More

Int J Surg Case Rep 2021 May 26;84:106030. Epub 2021 May 26.

Division of Oral and Maxillofacial Surgery, Department of Human Biology and Pathophysiology, School of Dentistry, Health Sciences University of Hokkaido, Hokkaido 061-0293, Japan.

Introduction: Mucoceles are mucous extravasation phenomena resulting from spontaneous ductal rupture or, less commonly, a traumatic cutting of a salivary excretory duct. Occasionally, the appearance of a mucocele closely resembles a neoplastic lesion, and it can be difficult to diagnose.

Presentation Of Case: A 74-year-old Japanese male patient was referred to our clinic with painless swelling related to the upper right canine-premolar area. Read More

Int J Surg Case Rep 2021 Jun 18;84:106117. Epub 2021 Jun 18.

Department of Radiology, Hamadan University of Medical Science, Hamadan, Iran. Electronic address:

Introduction: Gestational trophoblastic neoplasia comprises a unique group of human neoplastic diseases that derive from fetal trophoblastic tissues. The hydatidiform mole is the most common form of GTD, representing 80 % of cases. An invasive mole is a hydatidiform mole characterized by the enlarged hydropic villi invading into the myometrium, into vascular spaces, or into extrauterine sites. Read More

Clin Imaging 2021 Jun 18;77:276-282. Epub 2021 Jun 18.

Keck School of Medicine, University of Southern California, United States of America; Department of Radiology, University of Southern California, Los Angeles, CA 90033, United States of America.

Purpose: Racial and ethnic disparities have exacerbated during the COVID-19 pandemic as the healthcare system is overwhelmed. While Hispanics are disproportionately affected by COVID-19, little is known about ethnic disparities in the hospital settings. This study investigates imaging utilization and clinical outcomes between Hispanic and non-Hispanic COVID-19 patients in the Emergency Department (ED) and during hospitalization. Read More

Clin Imaging 2021 Jun 18;79:265-272. Epub 2021 Jun 18.

Istanbul University, Istanbul Medical Faculty, Radiology Department, Turkey.

Purpose: We aimed to compare COVID-19 imaging findings of young adults (19-35 years of age) with those of children (0-18 years) and to correlate imaging findings of young adults with their laboratory tests.

Materials And Methods: This retrospective study included Real Time-Polymerase Chain Reaction (RT-PCR) confirmed 130 young adults (mean age: 28.39 ± 4. Read More

Cell Calcium 2021 Jun 12;97:102435. Epub 2021 Jun 12.

Inserm UMR 1069, Nutrition Croissance Cancer, Faculté de Médecine, Université de Tours, F-37032, France. Electronic address:

The Transient Receptor Potential Vanilloid type 2 (TRPV2) channel is highly selective for Ca and can be activated by lipids, such as LysoPhosphatidylCholine (LPC). LPC analogues, such as the synthetic alkyl-ether-lipid edelfosine or the endogenous alkyl-ether-lipid Platelet Activating Factor (PAF), modulates ion channels in cancer cells. This opens the way to develop alkyl-ether-lipids for the modulation of TRPV2 in cancer. Read More

Pediatr Neurol 2020 Dec 1;121:75-80. Epub 2020 Dec 1.

Epilepsy Center, Neurological Institute, Cleveland Clinic, Cleveland Ohio.

The purpose of this review is to provide a comprehensive update and highlight the distinct electroclinical features and discuss recent advances in the etiology, pathophysiology, and management strategies of epilepsy with eyelid myoclonia. Recent studies indicate that variations of certain genes including CHD2 (chromodomain helicase DNA-binding protein 2), KCNB1, KIAA2022, and NAA10 may occur in these patients. It has been postulated that the occipital cortex may play a role in the pathophysiology. Read More

Phys Med 2021 Jun 21;88:20-22. Epub 2021 Jun 21.

XtraininX - Technical Consulting, Sanddornweg 23 c, 22846 Norderstedt, Germany. Electronic address:

Replacing moving mechanics in computed tomography (CT) and digital breast tomosynthesis (DBT) has inspired numerous projects to develop alternative X-ray sources. While less suitable for CT, DBT is a viable target application for the multi-X-ray-source array tube suggested in Becker, A.E. Read More

Sleep Med 2021 Jun 5;84:187-194. Epub 2021 Jun 5.

Department of Neurology, The Second Medical Center, Sleep Medicine Research Center, National Clinical Research Centre for Geriatric Diseases, Chinese PLA General Hospital, Beijing, 100853, China; School of Medicine, Nankai University, Tianjin, 300071, China. Electronic address:

Background: Sleep deprivation can robustly affect vigilant attention. The insula is a key hub of the salience network that mediates shifting attention between endogenous and exogenous states. However, little is known regarding the involvement of insular functional connectivity in impaired vigilant attention after total sleep deprivation (TSD). Read More

Ultrason Sonochem 2021 Jun 18;76:105632. Epub 2021 Jun 18.

Jiangsu University, No. 301 Xuefu Road, Zhenjiang, Jiangsu 212013, People's Republic of China. Electronic address:

A method for degrading organic pollutants in suspension by applying laser-induced cavitation is presented. Cavitation bubbles are produced remotely by laser beams, achieving a purpose of non-contact degradation. In this work, laser-induced bubble dynamics in SiO sand suspension were studied by high-speed imaging. Read More

Clin Neurol Neurosurg 2021 Jun 17;207:106766. Epub 2021 Jun 17.

Department of Neurosurgery and Neurooncology, First Faculty of Medicine, Charles University and Military University Hospital, Prague, Czech Republic; First Faculty of Medicine, Charles University in Prague, Prague, Czech Republic.

Objective: Subtotal meningioma resection (STR) is often performed to minimize surgical morbidity. Nevertheless, only a few studies have reported on patient outcome after STR. We studied the long-term outcome of SIV (Simpson grade IV) resection and identified predictive factors of overall survival (OS), progression-free survival (PFS) and time to progression (TTP). Read More

Biosens Bioelectron 2021 Jun 17;190:113449. Epub 2021 Jun 17.

Key Laboratory of Luminescence Analysis and Molecular Sensing (Southwest University), Ministry of Education, College of Chemistry and Chemical Engineering, Southwest University, Chongqing, 400715, PR China. Electronic address:

Here, the gold-silver nanocluster supramolecular network (AuAg NCs) is synthesized by the assembly of Au nanoclusters (Au NCs) and Ag NCs via host-guest complexation between 6-aza-2-thiothymine as the stabilizer of Au NCs and L-arginine as the stabilizer of Ag NCs in solution, whose electrochemiluminescence (ECL) emission is not only exceptionally stronger than that of discrete monometallic NCs, but also more significant than that of agminated monometallic NCs. The dramatically enhanced ECL emission of self-assembled AuAg NCs originates from the synergistic effect of aggregation-induced enhancement and silver effect in gold catalysis. As a proof of concept, the self-assembled AuAg NCs is successfully applied in the ultrasensitive detection of breast cancer biomarker microRNAs-21 (miR-21), which guides a new pathway for creating high-quality nano-optical elements in chemical sensors, biological imaging, and lightemitting devices. Read More

J Pharm Biomed Anal 2021 Jun 17;203:114217. Epub 2021 Jun 17.

Faculty of Chemistry, Bu-Ali Sina University, Hamedan 6517838695, Iran; D-8 International University, Hamedan, Iran.

A polymer dot modified histidine-functionalized graphene quantum dot carrier, [email protected], was synthesized to investigate the in vitro sunitinib (STB) deliveryvia luminescence spectrometer. The carrier's synthesis, with an average size of 34 nm, was proved by Fourier transform infrared (FTIR), Transmission Electron Microscopy (TEM), and Dynamic Light Scattering (DLS) analyses. Read More

Biochem Biophys Res Commun 2021 Jun 21;567:161-165. Epub 2021 Jun 21.

Laboratory of Molecular Neuroscience, Medical Research Institute, Tokyo Medical and Dental University (TMDU), Tokyo, Japan; The Center for Brain Integration Research, Tokyo Medical and Dental University (TMDU), Tokyo, Japan. Electronic address:

Attention-deficit/hyperactivity disorder (ADHD) is a common neuropsychiatric disorder in children. Although animal models and human brain imaging studies indicate a significant role for glutamatergic dysfunction in ADHD, there is no direct evidence that glutamatergic dysfunction is sufficient to induce ADHD-like symptoms. The glial glutamate transporter GLT1 plays a critical role in glutamatergic neurotransmission. Read More

Biomaterials 2021 Jun 18;275:120979. Epub 2021 Jun 18.

MOE Key Laboratory of Bioinorganic and Synthetic Chemistry, School of Chemistry, Sun Yat-Sen University, Guangzhou, 510006, PR China; MOE Key Laboratory of Theoretical Organic Chemistry and Functional Molecule, School of Chemistry and Chemical Engineering, Hunan University of Science and Technology, Xiangtan, 400201, PR China. Electronic address:

The diagnosis and treatment of cancer is one of the biggest medical challenges of the century. Despite significant improvements, there remains an urgent need for novel anticancer procedures. Among the most promising approaches, increasing attention has been devoted towards photothermal and sonodynamic therapy in which sensitizers are activated upon light/ultrasound radiation to generate a cytotoxic effect. Read More

Clin Imaging 2021 Jun 18;78:247-249. Epub 2021 Jun 18.

Mallinckrodt Institute of Radiology, Washington University School of Medicine, United States.

We report two cases of myocarditis, in two young and previously healthy individuals, temporally related to the second dose of the mRNA-COVID-19 vaccine. Both patients developed acute chest pain, changes on electrocardiogram (ECG), and elevated serum troponin within two days of receiving their second dose. Cardiac magnetic resonance (CMR) findings were consistent with acute myocarditis. Read More

Comput Biol Med 2021 Jun 4;135:104528. Epub 2021 Jun 4.

Faculty for Mathematics and Informatics, Friedrich-Schiller-University Jena, Ernst-Abbe-Platz 2, 07743, Jena, Germany.

A variety of medical imaging procedures, cadaver experiments, and computer models have been utilized to capture, depict, and understand the motion of the human lumbar spine. Particular interest lies in assessing the relative movement between two adjacent vertebrae, which can be represented by a temporal evolution of finite helical axes (FHA). Mathematically, this FHA evolution constitutes a seven-dimensional quantity: one dimension for the time, two for the (normalized) direction vector, another two for the (unique) position vector, as well as one for each the angle of rotation around and the amount of translation along the axis. Read More

J Mech Behav Biomed Mater 2021 Jun 18;121:104645. Epub 2021 Jun 18.

Department of Radiology, Charité, Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Charitéplatz 1, 10117, Berlin, Germany. Electronic address:

Purpose: Many elastography studies have shown that liver stiffness increases with fibrosis and thus can be used as a reliable marker for noninvasively staging fibrosis. However, the sensitivity of viscosity-related mechanical parameters, such as shear wave dispersion, to liver fibrosis is less well understood.

Methods: In this proof-of-concept study, 15 healthy volunteers and 37 patients with chronic liver disease and biopsy-proven fibrosis were prospectively investigated by MR elastography at six drive frequencies of 35-60 Hz. Read More

Neuroimage Clin 2021 Jun 17;31:102732. Epub 2021 Jun 17.

Department of Radiology, Washington University School of Medicine, St. Louis, MO 63110, USA; Department of Neurology, Washington University School of Medicine, St. Louis, MO 63110, USA; Department of Biomedical Engineering, Washington University in St. Louis, St. Louis, MO 63130, USA. Electronic address:

Objective: To prospectively determine whether diffusion basis spectrum imaging (DBSI) detects, differentiates and quantitates coexisting inflammation, demyelination, axonal injury and axon loss in mice with optic neuritis (ON) due to experimental autoimmune encephalomyelitis (EAE), and to determine if DBSI accurately measures effects of fingolimod on underlying pathology.

Methods: EAE was induced in 7-week-old C57BL/6 female mice. Visual acuity (VA) was assessed daily to detect onset of ON after which daily oral-treatment with either fingolimod (1 mg/kg) or saline was given for ten weeks. Read More

J Thorac Oncol 2021 Jun 21. Epub 2021 Jun 21.

Department of Oncology and Pharmacology, Mayo Clinic, Rochester, MN, USA.

Introduction: Screening for COVID-19 exposure, coupled with engaged decision making to prioritize cancer treatment in parallel with reducing risk of exposure and infection, is crucial in the management of COVID-19 during cancer treatment. Following two reported case studies of imaging findings during daily computed tomography (CT) -based image guided radiotherapy scans, a call for submission of anonymized case reports was published with the objective of rapidly determining if there was a correlation between the onset of new pulmonary infiltrates seen during radiotherapy and COVID-19. We hereby report the results of the aggregate analysis. Read More

Contemp Clin Trials 2021 Jun 21:106488. Epub 2021 Jun 21.

Division of Geriatrics and Gerontology, Department of Medicine, University of Wisconsin School of Medicine and Public Health, and Geriatric Research, Education and Clinical Center, Veterans Administration Hospital, Madison, WI 53705, USA.

The LUCINDA Trial (Leuprolide plus Cholinesterase Inhibition to reduce Neurologic Decline in Alzheimer's) is a 52 week, randomized, placebo-controlled trial of leuprolide acetate (Eligard) in women with Alzheimer's disease (AD). Leuprolide acetate is a gonadotropin analogue commonly used for hormone-sensitive conditions such as prostate cancer and endometriosis. This repurposed drug demonstrated efficacy in a previous Phase II clinical trial in those women with AD who also received a stable dose of the acetylcholinesterase inhibitor donepezil (Bowen et al. Read More

J Am Coll Surg 2021 Jun 14. Epub 2021 Jun 14.

Department of Surgery, Indiana University School of Medicine, Indianapolis, IN; Walther Oncology Center, Indianapolis, IN; Indiana University Simon Cancer Center, Indianapolis, IN; Indiana University Health Pancreatic Cyst and Cancer Early Detection Center, Indianapolis, IN; Department of Biochemistry/Molecular Biology, Indiana University School of Medicine, Indianapolis, IN; Center for Outcomes Research in Surgery, Indiana University School of Medicine, Indianapolis, IN. Electronic address:

Introduction: Pancreatic cysts are incidentally detected in up to 13% of patients undergoing radiographic imaging. Of the most frequently encountered types, mucin-producing (mucinous) pancreatic cystic lesions may develop into pancreatic cancer, while non-mucinous ones have little or no malignant potential. Accurate preoperative diagnosis is critical for optimal management but has been difficult to achieve, resulting in unnecessary major surgery. Read More

J AAPOS 2021 Jun 21. Epub 2021 Jun 21.

Department of Ophthalmology, The Children's Hospital at Westmead, NSW, Australia; Save Sight Institute, Sydney Medical School, Faculty of Medicine and Health, The University of Sydney.

IgG4-related disease is a chronic fibroinflammatory disorder that is becoming increasingly recognized in the pediatric population. The orbit is one of the most commonly affected sites. We present the youngest case of IgG4-related ophthalmic disease in the literature, with an immunodeficiency phenotype associated with a homozygous IRAK-4 variant gene. Read More

Semin Thorac Cardiovasc Surg 2021 Jun 21. Epub 2021 Jun 21.

Biofluid Mechanics Laboratory, Institute for Imaging Science and Computational Modelling in Cardiovascular Medicine, Charité-Universitätsmedizin Berlin, Berlin, Germany; Department of Cardiac Surgery, Medical University of Vienna, Vienna, Austria. Electronic address:

Treatment of univentricular hearts remains restricted to palliative surgical corrections (Fontan pathway). The established Fontan circulation lacks a sub-pulmonary pressure source and is commonly accompanied by progressively declining hemodynamics. A novel cavopulmonary assist device (CPAD) may hold the potential for improved therapeutic management of Fontan patients by chronic restoration of biventricular equivalency. Read More