Bone 2022 01 22;154:116235. Epub 2021 Oct 22.
Department of Oncology and Metabolism, University of Sheffield, Damer Street Building, Sheffield, S10 2TH, UK; Department of Radiology, Sheffield Children's NHS Foundation Trust, Western Bank, Sheffield, S10 2TH, UK; Highly Specialised Service for Severe, Complex and Atypical Osteogenesis Imperfecta (NHS England) - Birmingham Women's and Children's Hospital, UK; Bristol Royal Hospital for Children, UK; Great Ormond Street Hospital for Children NHS Foundation Trust, UK; Sheffield Children's Hospital NHS Foundation Trust, UK.
Objectives: In the context of a lack of national consensus on the benefits of skull base imaging in children with osteogenesis imperfecta (OI), this study aims to analyse and correlate the clinical symptoms and radiological images of children with severe OI.
Methods: A retrospective case notes and image analysis was carried out on children with complex OI between 2012 and 2018 at a specialist tertiary centre. Data were collected on patient demographic factors, clinical data, imaging findings (presence of Wormian bones, platybasia, basilar impression (McGregor's technique) and basilar invagination (McRae's technique)), and clinical features at the time of imaging. Read More