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Mol Imaging Biol 2019 Apr 11. Epub 2019 Apr 11.

Department of Nuclear Medicine, University Hospital Würzburg, Oberdürrbacher Str. 6, 97080, Wurzburg, Germany.

Purpose: The use of [F]fluoroethyl)-L-tyrosine ([F]FET) positron emission tomography/computed tomography (PET/CT) has proven valuable in brain tumor management. This study aimed to investigate the prognostic value of radiotracer uptake in newly diagnosed grade II or III gliomas according to the current 2016 World Health Organization (WHO) classification.

Procedures: A total of 35 treatment-naive patients (mean age, 48 ± 17 years) with histologically proven WHO grade II or III gliomas as defined by the current 2016 WHO classification were included. Read More

Asian J Neurosurg 2019 Jan-Mar;14(1):272-274

Department of Neurosurgery, Paras Hospital, Gurgaon, Haryana, India.

A 51-year-old male patient presented to us with an episode of generalized tonic-clonic seizure. Magnetic resonance imaging revealed a dural-based contrast-enhancing lesion in the right temporal lobe and another heterogeneously contrast-enhancing intra-axial lesion in the right insula adjacent to it. Histopathology confirmed it as a meningioma adjacent to an anaplastic oligodendroglioma. Read More

Neuroradiology 2019 May 2;61(5):545-555. Epub 2019 Feb 2.

Department of Radiology, Oslo University Hospital-Rikshospitalet, 4950 Nydalen, 0424, Oslo, Norway.

Purpose: According to the revised World Health Organization (WHO) Classification of Tumors of the Central Nervous System (CNS) of 2016, oligodendrogliomas are now defined primarily by a specific molecular signature (presence of IDH mutation and 1p19q codeletion). The purpose of our study was to assess the value of dynamic susceptibility contrast MR imaging (DSC-MRI) and diffusion-weighted imaging (DWI) to characterize oligodendrogliomas and to distinguish them from astrocytomas.

Methods: Seventy-one adult patients with untreated WHO grade II and grade III diffuse infiltrating gliomas and known 1p/19q codeletion status were retrospectively identified and analyzed using relative cerebral blood volume (rCBV) and apparent diffusion coefficient (ADC) maps based on whole-tumor volume histograms. Read More

J Med Imaging Radiat Oncol 2019 Apr 24;63(2):272-280. Epub 2019 Jan 24.

Northern Sydney Cancer Centre, Royal North Shore Hospital, Sydney, New South Wales, Australia.

Introduction: Assess survival of patients with anaplastic glioma (AG) and the relationship to molecular subtype.

Methods: Patients with AG managed with IMRT between 2008 and 2014 were entered into a prospective database assessing relapse-free survival (RFS) and overall survival (OS). Isocitrate dehydrogenase (IDH) mutations were assessed prospectively from 2011, and subsequent testing of historical patients allowing categorisation under WHO 2016 classification as anaplastic astrocytoma IDH wild type (AAwt), anaplastic astrocytoma IDH mutated (AAmut), anaplastic oligodendroglioma (AOD) or other glial tumour (OTH). Read More

Clin Nucl Med 2019 Mar;44(3):e168-e169

From the Department of Nuclear Medicine and Molecular Imaging, Ajou University School of Medicine, Suwon, South Korea.

F-FP-CIT PET is a useful modality for imaging dopamine transporters. It has excellent resolution compared with I-beta-CIT SPECT and is widely used clinically for the evaluation of Parkinson disease. In general, the main focus of F-FP-CIT PET imaging is the basal ganglia, and it is important to observe whether F-FP-CIT uptake is normal in the putamen and caudate nuclei. Read More

Oper Neurosurg (Hagerstown) 2018 Dec 19. Epub 2018 Dec 19.

Department of Neurosurgery, North Shore University Hospital, Zucker School of Medicine at Hofstra/Northwell, Manhasset, New York.

Background And Importance: Surgery for resection of tentorial meningiomas compressing primary visual cortex carries a significant risk of worsening vision. This concern is especially acute in patients with a preexisting visual deficit. Approaches that involve mechanical retraction of the occipital lobe further threaten visual function. Read More

J Comp Pathol 2018 Nov 29;165:62-66. Epub 2018 Oct 29.

Department of Animal Medicine and Surgery, Veterinary Faculty, Cerdanyola del Vallès, Spain; Networking Research Centre on Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), Universitat Autònoma de Barcelona, Cerdanyola del Vallès, Spain.

A 10-year-old entire male French bulldog was presented following clusters of generalized tonic-clonic epileptic seizures. Neurolocalization was consistent with a lesion in the left forebrain. Magnetic resonance imaging of the brain revealed a large, ill-defined, intra-axial, space-occupying lesion at the level of the left temporal and parietal lobes, causing marked compression of the adjacent parenchyma. Read More

Magn Reson Imaging 2019 04 19;57:254-258. Epub 2018 Nov 19.

Department of Radiology, Weill Cornell Medicine, New York, NY, USA. Electronic address:

Purpose: Texture analysis performed on MR images can detect quantitative features that are imperceptible to human visual assessment. The purpose of this study was to evaluate the feasibility of texture analysis on preoperative conventional MRI to discriminate between histological subtypes in low-grade gliomas (LGGs), and to determine the utility of texture analysis compared to histogram analysis alone.

Methods: A total of 41 patients with LGG, 21 astrocytoma and 20 1p/19q codeleted oligodendroglioma were included in this study. Read More

J Clin Neurosci 2019 Jan 14;59:68-74. Epub 2018 Nov 14.

Northern Sydney Cancer Centre, Royal North Shore Hospital, Sydney, Australia; Sydney Medical School, University of Sydney, Sydney, Australia; Sydney NeuroOncology Group, Sydney, Australia.

The role of maximal surgical debulking in isocitrate dehydrogenase (IDH) mutated anaplastic glioma prior to adjuvant radiation therapy remains uncertain. This study assessed the reduction in tumour volume following intensity modulated radiation therapy (IMRT) and temozolomide in this favourable and more responsive tumour pathology. 56 patients were managed from 2011 to 2014 and 53 had residual disease. Read More

Zh Vopr Neirokhir Im N N Burdenko 2018;82(5):5-20

Burdenko Neurosurgical Institute, Moscow, Russia.

Surgery of intracerebral tumors involving long association fibers is a challenge. In this study, we analyze the results of intraoperative mapping of the superior longitudinal, arcuate, and frontal aslant tracts in surgery of brain gliomas.

Purpose: The study purpose was to compare the results of intraoperative mapping and the postoperative speech function in patients with gliomas of the premotor area of the speech-dominant frontal lobe, which involved the superior longitudinal, arcuate, and frontal aslant tracts, who were operated on using awake craniotomy. Read More

Vet Med Sci 2019 02 5;5(1):5-18. Epub 2018 Nov 5.

Microspherix LLC, Bocan Raton, FL, USA.

Entotherapy an image-guided drug-eluting microcylinder platform, has the potential to bypass the limitations of systemic chemotherapy use in the treatment of canine brain tumours. Gliomas, which are common in dogs and also represent the majority of fatal brain tumours in humans, can be amenable to chemotherapy with temozolomide. Biopolymer microcylinders conjugated with temozolomide and gadolinium were implanted into partially resected tumours of four client-owned dogs with gliomas. Read More

Clin Neurol Neurosurg 2018 Dec 2;175:9-15. Epub 2018 Oct 2.

Department of Neurosurgery, University Hospital of Wales, Heath Park, Cardiff, CF14 4XW, UK.

Objectives: The majority of patients with supratentorial diffuse grade II glioma present with seizures, which adversely affect quality of life. The exact mechanism of epileptogenesis is unknown and the influence of tumour characteristics, radiological and histological, are not well studied, particularly following the introduction of molecular genetics in the 2016 WHO reclassification of gliomas. We sought to define predictors of seizure development and outcome in low grade glioma. Read More

Eur Radiol 2019 Apr 1;29(4):1893-1902. Epub 2018 Oct 1.

Department of Radiology, Institute of Surgery Research, Daping Hospital, Army Medical University, 10# Changjiang Branch Road, Chongqing, People's Republic of China, 400024.

Objectives: Vessel size imaging (VSI) could reveal average microvessel diameter. The aim was to investigate microvascular characteristics and the efficacy of VSI in lower-grade glioma (LGG) grading and subtype differentiation based on 2016 classification of central nervous system tumours.

Methods: Fifty-seven LGG (grade II/III, 36/21) patients who received VSI examination before surgery were retrospectively analysed. Read More

Neurochirurgie 2018 Dec 19;64(6):425-430. Epub 2018 Sep 19.

Service de neurochirurgie, CHU de Strasbourg, hôpital de Hautepierre, 67000 Strasbourg, France.

Spinal cord biopsy is a difficult procedure fraught with the risk of false-negative results or even misdiagnosis in up to 30% of cases. Differential diagnoses of spinal cord lesions include a wide range of inflammatory, infectious and neoplastic diseases. Given the importance of correctly managing these pathologies, it is crucial to avoid delays in making the correct diagnosis in order to improve the patient's outcome. Read More

Acta Neurol Belg 2018 Dec 21;118(4):603-605. Epub 2018 Sep 21.

Department of Neurosurgery, Chang Gung Memorial Hospital, Chang Gung University, No. 5 Fu-Shin Street, Gui-Shan Dist., Taoyuan, 33305, Taiwan, Republic of China.

Arteriovenous malformations (AVMs) usually manifest as headaches, seizures, focal neurological signs, and spontaneous intracerebral or subarachnoid hemorrhages. An untreated AVM with associated cyst formation is extremely rare, and the probable pathogenesis is unclear. We propose and discuss the possible pathogenesis of this condition and its diagnosis and management. Read More

J Neuropathol Exp Neurol 2018 Nov;77(11):1039-1054

National Cancer Institute, National Institutes of Health, Comparative Oncology Program, Center for Cancer Research, Bethesda, Maryland.

The National Cancer Institute-led multidisciplinary Comparative Brain Tumor Consortium (CBTC) convened a glioma pathology board, comprising both veterinarian and physician neuropathologists, and conducted a comprehensive review of 193 cases of canine glioma. The immediate goal was to improve existing glioma classification methods through creation of a histologic atlas of features, thus yielding greater harmonization of phenotypic characterization. The long-term goal was to support future incorporation of clinical outcomes and genomic data into proposed simplified diagnostic schema, so as to further bridge the worlds of veterinary and physician neuropathology and strengthen validity of the dog as a naturally occurring, translationally relevant animal model of human glioma. Read More

J Neurol Surg B Skull Base 2018 Oct 25;79(Suppl 4):S340-S346. Epub 2018 Jun 25.

Department of Neurosurgery, Capital Medical University, Beijing Tiantan Hospital, Beijing, China.

 Brainstem gliomas (BsG) account for 10 to 15% of pediatric brain tumors. Surgery is the preferred treatment for focal and exophytic lesions. Sodium fluorescein has been proven safe and effective in resection of malignant brain tumors. Read More

Front Neurol 2018 27;9:700. Epub 2018 Aug 27.

Department of Pathology, University of Texas MD Anderson Cancer Center, Houston, TX, United States.

We present a case of a 43-year-old woman with a history of headaches and blurry vision. Ophthalmologic examination identified papilledema. MR imaging demonstrated a right parietal region mass with patchy areas of contrast enhancement and focal calcifications. Read More

J Vet Med Sci 2018 Nov 6;80(10):1590-1595. Epub 2018 Sep 6.

Kyoto Animal Referral Medical Center, 208-4, Shinarami, Tai, Kumiyama-cho, Kuze-gun, Kyoto 613-0036, Japan.

A 2.5-year-old male French Bulldog was evaluated for seizures. Cranial magnetic resonance imaging (MRI) suggested a glioma in the left piriform area. Read More

Zh Vopr Neirokhir Im N N Burdenko 2018;82(4):87-96

Neurological Center of Latium, Rome, Italy; Department of Biomedicine, University of Rome Tor Vergata and NCL-Institute of Neurological Sciences, Rome, Italy.

Li-Fraumeni syndrome (LFS) is a clinically and genetically heterogeneous hereditary syndrome with predominantly oncological manifestations, which is associated with mutations in the TP53, MDM2, and CHEK2 genes. The most common variant is a TP53 mutation.

Objective: To analyze the literature and present a clinical case of a patient with Li-Fraumeni syndrome and multiple anaplastic oligodendrogliomas of the brain. Read More

No Shinkei Geka 2018 Aug;46(8):699-706

Department of Neurosurgery, Asahi General Hospital.

A 71-year-old woman was transferred to our hospital, complaining of a seizure for the first time. A tumor was detected in the right frontal lobe, and a craniotomy was performed with a partial tumor resection. The pathological diagnosis was oligodendroglioma with IDH mutation and 1p/19q codeletion, and irradiation therapy was performed. Read More

Neuropathology 2018 Oct 26;38(5):557-560. Epub 2018 Jul 26.

Pathology Unit, Department of Diagnostics and Public Health, University and Hospital Trust of Verona, Verona, Italy.

Low-grade neuroepithelial tumors (LGNT) show a broad histopathological spectrum and may be difficult to classify using current World Health Organization (WHO) criteria. A 57-year-old man came to medical attention because of headaches. The patient medical history was otherwise unremarkable. Read More

Brain Tumor Pathol 2018 Oct 26;35(4):209-216. Epub 2018 Jul 26.

Department of Neurosurgery, Hamamatsu University School of Medicine, 1-20-1, Handayama, Higashi-ku, Hamamatsu, 431-3192, Japan.

Diffuse leptomeningeal glioneuronal tumor (DLGNT) is a rare glioneuronal neoplasm with oligodendroglioma-like cells confined in the subarachnoid spaces. A great majority of DLGNT are histologically low grade. However, some tumors show features of anaplasia with increased mitotic and proliferative activity. Read More

Clin Neurol Neurosurg 2018 Sep 20;172:177-182. Epub 2018 Jul 20.

Department of Neurosurgery, University Medical Center Regensburg, Regensburg, Germany; Wilhelm-Sander Neuro-Oncology Unit, University Medical Center Regensburg, Regensburg, Germany.

Objectives: We report on five patients with gadolinium-negative (non-enhancing magnetic resonance imaging-MRI) but F-fluoroethyl tyrosine positron-emission tomography (FET-PET) positive glioma (NEG) undergoing surgery under fluorescence-guidance with fluorescein sodium 10% (FL, Alkon, Germany) in combination with a dedicated light filter (YELLOW 560 nm, Carl Zeiss Meditec, Germany).

Patients And Method: Since 2017, five patients (3 female, 2 male; mean age 45.4 years) underwent fluorescence-guided surgery for supratentorial, intracerebral lesions which showed no contrast-enhancement in the preoperative MRI but were, however, strongly suspicious for gliomas. Read More

Brain Tumor Pathol 2018 Jul 20;35(3):186-191. Epub 2018 Jul 20.

Department of Pathology, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, 110029, India.

Diffuse leptomeningeal glioneuronal tumor (DL-GNT) is a newly introduced tumor entity of uncertain prognosis characterised by a primary diffuse leptomeningeal growth pattern, oligodendroglial-like morphology and dual glial/neuronal differentiation. Predominantly occurring in children, these tumors present as chronic meningitis and mimic infectious/inflammatory diseases. They are surgically challenging tumors with a high incidence of delayed morbidity and mortality despite low-grade histology. Read More

BMJ Case Rep 2018 Jun 28;2018. Epub 2018 Jun 28.

Department of Neurology, Washington University in Saint Louis School of Medicine, St Louis, Missouri, USA.

Tumefactive appearing lesions on brain imaging can cause a diagnostic dilemma. We report a middle-aged man who presented with right-sided optic neuritis. A brain MRI showed enhancement of the right optic nerve, and non-enhancing white matter lesions including a 3 cm right frontal lesion with adjacent gyral expansion. Read More

Magn Reson Imaging 2018 10 11;52:75-83. Epub 2018 Jun 11.

Service de Biophysique et Médecine Nucléaire, Hôpitaux Universitaires de Strasbourg, France; ICube, Université de Strasbourg/CNRS (UMR 7357), Strasbourg, France; Fédération de Médecine Translationnelle de Strasbourg (FMTS), Faculté de Médecine, Strasbourg, France.

Purpose: The aim of this study was to study the relationship between MRSI, before and after surgery, and patient survival. The accuracy of pre-operative MRSI in differentiating low- from high-grade oligodendrogliomas (ODGs) was also studied.

Methods: Two hundred patients with ODG were retrospectively included in this study between 2000 and 2016. Read More

Brain Lang 2018 08 18;183:41-46. Epub 2018 May 18.

Department of Neurosurgery, David Geffen School of Medicine at UCLA, Los Angeles, CA, United States; Semel Neuropsychiatric Institute, Brain Research Institute, Center for Cognitive Neurosciences and Department of Pscychology, University of California, Los Angeles, Los Angeles, CA, United States.

We evaluated plasticity in speech supplemental motor area (SMA) tissue in two patients using functional magnetic resonance imaging (fMRI), following resection of tumors in or associated with the dominant hemisphere speech SMA. Patient A underwent resection of a anaplastic astrocytoma NOS associated with the left speech SMA, experienced SMA syndrome related mutism postoperatively, but experienced full recovery 14 months later. FMRI performed 32 months after surgery demonstrated a migration of speech SMA to homologous contralateral hemispheric regional tissue. Read More

World Neurosurg 2018 Aug 5;116:e534-e542. Epub 2018 Jun 5.

Department of Veterinary Clinical Sciences, Purdue University, West Lafayette, Indiana, USA; Department of Neurological Surgery, Indiana University School of Medicine, Indianapolis, Indiana, USA. Electronic address:

Objective: Metronomic (daily low-dose) chlorambucil requires further study before use in human patients with glioma. The aim of this study was to investigate distribution and safety of metronomic chlorambucil in naturally occurring canine glioma.

Methods: Eight client-owned (pet) dogs with newly diagnosed spontaneous glioma were prospectively enrolled. Read More

Sci Rep 2018 May 17;8(1):7792. Epub 2018 May 17.

Wellcome Centre for Integrative Neuroimaging, FMRIB Division, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, OX3 9DU, UK.

Magnetic resonance spectroscopic imaging (MRSI) is a promising technique in both experimental and clinical settings. However, to date, MRSI has been hampered by prohibitively long acquisition times and artifacts caused by subject motion and hardware-related frequency drift. In the present study, we demonstrate that density weighted concentric ring trajectory (DW-CRT) k-space sampling in combination with semi-LASER excitation and metabolite-cycling enables high-resolution MRSI data to be rapidly acquired at 3 Tesla. Read More

World Neurosurg 2018 Jul 5;115:373-383. Epub 2018 May 5.

Division of Neurosurgery, Department of Surgery, Royal University Hospital, Saskatoon, Saskatchewan, Canada; Department of Psychology, University of Saskatchewan, Saskatoon, Saskatchewan, Canada. Electronic address:

Background: We report the case of a 40-year-old patient with a large, World Health Organization grade III oligodendroglioma in the left parietal lobe.

Case Description: Presurgical planning included functional magnetic resonance imaging (fMRI) localization of language, motor, and somatosensory processing. fMRI results for motor and somatosensory tasks revealed activation in perilesional regions near the surgical resection as well as deactivation in the tumor for the sensory task, suggesting decreased autoregulation in the region owing to the glioma. Read More

Medicine (Baltimore) 2018 Apr;97(17):e0594

Department of Oncology, Laiyang Central Hospital of Yantai,Yantai, ShanDong, China.

Rationale: Oligodendrogliomas are usually located in the frontal, parietal and the temporal lobe, with the ones in the fourth ventricle quite rare. Hence we want to introduce a case about the rare disease.

Patient Concerns: An eight-year old boy complained of progressive headache, dizziness and vomit for about 2 months. Read More

J Med Case Rep 2018 Apr 25;12(1):106. Epub 2018 Apr 25.

Department of Clinical Laboratory Medicine, Kyoto University Graduate School of Medicine, 54 Shogoin-Kawara-cho, Sakyo-ku, Kyoto, 606-8507, Japan.

Background: Staphylococcus epidermidis can cause nosocomial meningitis in the presence of prosthetic devices. We describe a case of Staphylococcus epidermidis meningitis in a patient with neutropenia who had no intracranial foreign body, and we review the literature on meningitis that is caused by coagulase-negative Staphylococcus spp. without a neurosurgical device. Read More

Asian J Neurosurg 2018 Apr-Jun;13(2):471-474

Department of Neurosurgery, South City Hospital, Clifton, Karachi, Pakistan.

The past few years have seen increasing support for gross total resection in the management of low-grade gliomas (LGGs), with a greater extent of resection correlated with better overall survival, progression-free survival, and time to malignant transformation. There is consistent evidence in literature supporting extent of safe resection as a good prognostic indicator as well as positively affecting seizure control, symptomatic relief in pressure symptoms, and longer progression-free and total survival. The operative goal in most LGG cases is to maximize the extent of resection for these benefits while avoiding postoperative neurologic deficits. Read More

BMJ Case Rep 2018 Mar 30;2018. Epub 2018 Mar 30.

Department of Neurosurgery, King Abdulaziz Medical City, King Saud bin Abdulaziz University for Health Sciences, King Abdullah International Medical Research Center Ministry of National Guard Health Affairs, Riyadh, Saudi Arabia.

Apixaban is a factor Xa inhibitor which is a non-vitamin K dependent oral anticoagulant known tocause the lowest rate of intracranial bleeding among the same kind of inibitors. In this paper, we report a rare case in a 60-year-old man with a history of hypertension and oligodendroglioma on apixaban for deep venous thrombosis who presented to our hospital with decreased level of consciousness and slurred speech with rapid deterioration. We highlight the risk of subdural bleeding requiring immediate neurosurgical intervention due to apixaban, with literature review. Read More

World Neurosurg 2018 Jun 9;114:53-57. Epub 2018 Mar 9.

Department of Neurosurgery, Santa Corona Hospital, Pietra Ligure, Italy.

Background: Diffuse leptomeningeal glioneuronal tumor (DLGNT) was recently added to the World Health Organization classification of central nervous system tumors. DLGNT is a rare entity that occurs more commonly in pediatric patients, but occasional cases have been reported in adults. This tumor has been recognized as a distinct pathologic entity; however, its biologic behavior remains unclear. Read More

AJNR Am J Neuroradiol 2018 Apr 8;39(4):687-692. Epub 2018 Mar 8.

Department of Anatomical Pathology (M.G.), The Royal Melbourne Hospital, Parkville, Victoria, Australia.

Background And Purpose: The 2016 revision of the mandates codeletion of chromosomes 1p and 19q for the diagnosis of oligodendroglioma. We studied whether conventional MR imaging features could predict 1p/19q status.

Materials And Methods: Patients with previous 1p/19q testing were identified through pathology department records, typically performed on the basis of an oligodendroglial component on routine histology; 69 patients met the inclusion criteria. Read More

Neuroradiol J 2018 Aug 22;31(4):379-385. Epub 2018 Feb 22.

1 Department of Radiology, SUNY Upstate Medical University, Syracuse, NY, USA.

Purpose We explored whether advanced magnetic resonance (MR) imaging techniques could grade oligodendrogliomas. Methods Forty patients (age 9-61 years) with oligodendroglial tumors were selected. There were 23 patients with World Health Organization grade II (group 1) and 17 patients with grade III (group 2) tumors. Read More

Clin Neuroradiol 2018 Feb 21. Epub 2018 Feb 21.

Department of Neuroradiology, Eberhard Karls University, Hoppe-Seyler-Str. 3, 72076, Tübingen, Germany.

Purpose: To assess the diagnostic performance of dynamic susceptibility contrast perfusion magnetic resonance perfusion imaging (DSC-MRI) for in vivo human glioma molecular profiling.

Methods: In this study 100 patients with histopathologically confirmed glioma who provided written informed consent were retrospectively assessed between January 2016 and February 2017 in two prospective trials that were approved by the local institutional review board. Cerebral blood volume (CBV) measurements from DSC-MRI were assessed, and histogram parameters of relative CBV (rCBV) results were compared among World Health Organization (WHO) 2016 based histological findings and molecular characteristics. Read More

World Neurosurg 2018 May 10;113:62-66. Epub 2018 Feb 10.

Memorial Hospital, Neurosurgery Clinic, Ankara, Turkey.

Background: Oligodendrogliomas constitute 5% of all primary brain tumors and are the third most common cancer among intracranial tumors. More than 90% of oligodendrogliomas have supratentorial localization. Oligodendrogliomas arising in cerebellar peduncle are substantially rare, <1%. Read More

Br J Neurosurg 2018 Feb 12;32(1):18-27. Epub 2018 Feb 12.

b Radiological Sciences, Division of Clinical Neuroscience , University of Nottingham , Nottingham , UK.

Background: Despite previous identification of pre-operative clinical and radiological predictors of post-operative paediatric cerebellar mutism syndrome (CMS), a unifying pre-operative risk stratification model for use during surgical consent is currently lacking. The aim of the project is to develop a simple imaging-based pre-operative risk scoring scheme to stratify patients in terms of post-operative CMS risk.

Methods: Pre-operative radiological features were recorded for a retrospectively assembled cohort of 89 posterior fossa tumour patients from two major UK treatment centers (age 2-23yrs; gender 28 M, 61 F; diagnosis: 38 pilocytic astrocytoma, 32 medulloblastoma, 12 ependymoma, 1 high grade glioma, 1 pilomyxoid astrocytoma, 1 atypical teratoid rhabdoid tumour, 1 hemangioma, 1 neurilemmoma, 2 oligodendroglioma). Read More

Can J Neurol Sci 2018 05 12;45(3):360-362. Epub 2018 Feb 12.

3Division of Neurosurgery,Nova Scotia Health AuthorityQueen Elizabeth II Health Science Centre (Halifax Infirmary)Dalhousie University,Halifax,NS,Canada.

CNS Oncol 2018 01 2;7(1):1-5. Epub 2018 Feb 2.

Department of Neurosciences, College of Medicine - Philippine General Hospital, University of the Philippines Manila, Taft Avenue, Ermita, Manila, 1000, Philippines.

Widespread primary spinal oligodendrogliomas are a rare variety of tumors that usually affect children. Currently, there are only two adult cases reported worldwide. We report the first case of primary holocord oligodendroglioma with intracranial extension in a young adult female. Read More

CNS Oncol 2018 01 1;7(1):7-13. Epub 2018 Feb 1.

Department of Neurology, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA.

Interpretation of MRI abnormalities in patients with malignant gliomas (MG) treated with bevacizumab is challenging. Recent reports describe quantitative analyses of diffusion-weighted imaging abnormalities not available in standard clinical settings, to differentiate tumor recurrence from treatment necrosis. We retrospectively reviewed bevacizumab treated MG patients who underwent surgery or autopsy to correlate radiographic recurrence patterns with pathologic findings. Read More

Int J Neurosci 2018 Sep 19;128(9):886-890. Epub 2018 Feb 19.

a Department of Neurology , Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology , Wuhan , China.

Diffuse Low-Grade Gliomas (LGGs) include World Health Organization (WHO) grade II diffuse astrocytoma, oligodendroglioma and oligoastrocytoma. Since the neurological symptoms of LGGs are often subtle and deceptive, LGGs are easily overlooked at their early stage. Here, we report a case of a 49-year-old female with symptoms and imaging manifestations mimicking ischaemic infarct. Read More

Cochrane Database Syst Rev 2018 Jan 22;1:CD011551. Epub 2018 Jan 22.

Department of Imaging and Interventional Radiology, The Chinese University of Hong Kong, Prince of Wales Hospital, 30 Ngan Shing St, Shatin, Hong Kong.

Background: Gliomas are the most common primary brain tumour. They are graded using the WHO classification system, with Grade II-IV astrocytomas, oligodendrogliomas and oligoastrocytomas. Low-grade gliomas (LGGs) are WHO Grade II infiltrative brain tumours that typically appear solid and non-enhancing on magnetic resonance imaging (MRI) scans. Read More

J Neurooncol 2018 Feb 11;136(3):523-531. Epub 2017 Dec 11.

Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, 10050, People's Republic of China.

In this study we aimed to identify the anatomic features of 1p/19q co-deletion and investigate the predictive values of tumor location and radiological characteristics for the survival of anaplastic oligodendroglial (AO) glioma patients. Voxel-based lesion-symptom mapping (VLSM) analysis was applied to define the brain regions associated with occurrence of 1p/19q co-deletion in a cohort of 206 AO tumor patients (discovery set) treated between May 2009 and September 2013. Retrospectively, the acquired clusters and radiological features were subjected to Kaplan-Meier survival analysis using data from the Chinese Glioma Genome Atlas (validation set) to evaluate their prognostic role in AO patients. Read More

Br J Radiol 2018 Feb 22;91(1082):20170426. Epub 2018 Jan 22.

3 Department of Surgical Sciences, Uppsala University , Uppsala , Sweden.

Objective: To perform a meta-analysis evaluating the diagnostic accuracy of C-methionine (MET) positron emission tomography (PET) to discriminate between primary low-grade glioma (LGG) and high-grade glioma (HGG).

Methods: A systematic database search was performed by a librarian in relevant databases with the latest search on 07 November 2016. Hits were assessed for inclusion independently by two authors. Read More

J Neurooncol 2018 Feb 15;136(3):533-539. Epub 2017 Nov 15.

Service de Neuro-Oncologie, Groupe Hospitalier Est, Hospices Civils de Lyon, 59 Bvd Pinel, 69394, Lyon Cedex, France.

Although upfront temozolomide (TMZ) has been widely-used to treat 1p/19q-codeleted diffuse low-grade gliomas (LGG), its long-term impact on the growth kinetics of these tumors has not been determined. Based on serial magnetic resonance images we retrospectively evaluated the evolution of the mean tumor diameter (MTD) in 36 progressive 1p/19q-codeleted LGG treated with upfront TMZ. After TMZ onset, all but two patients (94. Read More

J Magn Reson Imaging 2018 07 15;48(1):74-83. Epub 2017 Nov 15.

Department of Radiology, Huashan Hospital, Fudan University, Shanghai, P.R. China.

Background: The genetic status of 1p/19q is important for differentiating oligodendroglioma, isocitrate-dehydrogenase (IDH)-mutant, and 1p/19q-codeleted from diffuse astrocytoma, IDH-mutant according to the 2016 World Health Organization (WHO) criteria.

Purpose: To assess the value of magnetic resonance textural analysis (MRTA) on T fluid-attenuated inversion recovery (FLAIR) images for making a genetically integrated diagnosis of true oligodendroglioma by WHO guidelines.

Study Type: Retrospective case control. Read More