Neurobiol Dis 2022 Aug 25;170:105776. Epub 2022 May 25.
Brain Health Imaging Institute, Department of Radiology, Weill Cornell Medicine, New York, NY, USA. Electronic address:
Cerebrospinal fluid (CSF), predominantly produced in the ventricles and circulating throughout the brain and spinal cord, is a key protective mechanism of the central nervous system (CNS). Physical cushioning, nutrient delivery, metabolic waste, including protein clearance, are key functions of the CSF in humans. CSF volume and flow dynamics regulate intracranial pressure and are fundamental to diagnosing disorders including normal pressure hydrocephalus, intracranial hypotension, CSF leaks, and possibly Alzheimer's disease (AD). Read More