741 results match your criteria Imaging in Mucinous Cystic Neoplasms of the Pancreas


Impact of endoscopic ultrasound on diagnosis and management of presumed mucinous neoplasms when done for pancreatic cyst morphology change on non-invasive surveillance imaging.

Endosc Int Open 2019 Apr 15;7(4):E389-E395. Epub 2019 Mar 15.

Department of Digestive Diseases, Yale School of Medicine, New Haven, CT.

 Guidelines for management of presumed neoplastic pancreatic cysts have encouraged noninvasive imaging for low-risk surveillance, while reserving endoscopic ultrasound for worrisome features including morphologic change. We aim to study the impact of endoscopic ultrasound on diagnosis and management compared with non-invasive imaging.  A single-institution pancreatic cyst database was retrospectively queried for patients who underwent endoscopic ultrasound for the indication of change in cyst morphology. Read More

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http://dx.doi.org/10.1055/a-0824-6240DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6420337PMC
April 2019
1 Read

Are BRCA1 and BRCA2 gene mutation patients underscreened for pancreatic adenocarcinoma?

J Surg Oncol 2019 May 12;119(6):777-783. Epub 2019 Jan 12.

Department of Surgery, Indiana University School of Medicine, Indianapolis, Indiana.

Background: Breast cancer (BRCA) mutations account for the highest proportion of hereditary causes of pancreatic ductal adenocarcinoma (PDAC). Screening is currently recommended only for patients with one first-degree relative or two family members with PDAC. We hypothesized that screening all BRCA1/2 patients would identify a higher rate of pancreatic abnormalities. Read More

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http://dx.doi.org/10.1002/jso.25376DOI Listing
May 2019
3 Reads

[Cystic lesions of the pancreas : Differential diagnostics and treatment].

Authors:
J Rosendahl P Michl

Internist (Berl) 2019 Mar;60(3):219-225

Klinik für Innere Medizin I, Universitätsklinikum Halle (Saale), Ernst-Grube-Str. 40, 06120, Halle (Saale), Deutschland.

Cystic space-occupying lesions of the pancreas represent incidental findings in most cases. As there is a potential risk of malignant transformation further evaluation of the lesions as well as a follow-up of these patients is usually recommended. Before this work-up is initiated the clinical situation of the patient as a whole and comorbidities, age and personal preferences have to be taken into account. Read More

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http://dx.doi.org/10.1007/s00108-018-0547-6DOI Listing
March 2019
1 Read

Systematic review of the utility of 18-FDG PET in the preoperative evaluation of IPMNs and cystic lesions of the pancreas.

Surgery 2018 Dec 18. Epub 2018 Dec 18.

Department of Hepatopancreatobiliary and Transplant Surgery, Singapore General Hospital; Duke-NUS Medical School, Singapore. Electronic address:

Background: The aim of this systematic review is to assess the role of 18-fluorodeoxyglucose positron emission tomography in the preoperative evaluation of intraductal papillary mucinous neoplasms and cystic lesions of the pancreas.

Methods: A computerized PubMed search was conducted according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines to identify studies evaluating positron emission tomography in the preoperative evaluation of pancreatic cystic lesions.

Results: A total of 14 studies evaluated the role of 18-fluorodeoxyglucose positron emission tomography/positron emission tomography-computed tomography, 9 of which evaluated only intraductal papillary mucinous neoplasms and 5 evaluated all pancreatic cystic lesions, including intraductal papillary mucinous neoplasms. Read More

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http://dx.doi.org/10.1016/j.surg.2018.11.006DOI Listing
December 2018
2 Reads

Diagnosis and management of intraductal papillary mucinous neoplasms of the pancreas.

Acta Biomed 2018 Dec 17;89(9-S):147-152. Epub 2018 Dec 17.

Gastroenterology Unit, Molinette Hospital, Torino University, Torino.

Background And Aim Of The Work: Intraductal papillary mucinous neoplasms (IPMN) of the pancreas are cystic lesions with malignant potential. Given their increasing incidence in the latest years, a precise characterization and management of these lesions have become more and more crucial: even though the majority of IPMN has a benign and indolent course, it is fundamental to early recognize and stratify patients in order to accurately plan a tailored follow-up and to individuate those that would benefit of surgical treatment. The aim of this paper is to highlight the most recent evidence on IPMN available in the current literature. Read More

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http://dx.doi.org/10.23750/abm.v89i9-S.7958DOI Listing
December 2018
1 Read

Effect of a region-wide incorporation of an algorithm based on the 2012 international consensus guideline on the practice pattern for the management of pancreatic cystic neoplasms in an integrated health system.

World J Clin Cases 2018 Nov;6(13):624-631

School of Medicine, University of California, Riverside, CA 92521, United States.

Aim: To examine the practice pattern in Kaiser Permanente Southern California (KPSC), ., gastroenterology (GI)/surgery referrals and endoscopic ultrasound (EUS), for pancreatic cystic neoplasms (PCNs) after the region-wide dissemination of the PCN management algorithm.

Methods: Retrospective review was performed; patients with PCN diagnosis given between April 2012 and April 2015 (18 mo before and after the publication of the algorithm) in KPSC (integrated health system with 15 hospitals and 202 medical offices in Southern California) were identified. Read More

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http://www.wjgnet.com/2307-8960/full/v6/i13/624.htm
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http://dx.doi.org/10.12998/wjcc.v6.i13.624DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6232565PMC
November 2018
25 Reads

Cystic Pancreatic Tumors.

Magn Reson Imaging Clin N Am 2018 Aug;26(3):405-420

Department of Radiology, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA.

Cystic pancreatic lesions are common and often incidentally detected on cross-sectional examinations of the abdomen. Most lesions are asymptomatic and benign. However, some carry a significant risk of malignant degeneration, so correct identification, complete characterization, and adequate follow-up/management of these lesions are paramount. Read More

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http://dx.doi.org/10.1016/j.mric.2018.03.006DOI Listing
August 2018
6 Reads

Identification of Cystic Lesions by Secondary Screening of Familial Pancreatic Cancer (FPC) Kindreds Is Not Associated with the Stratified Risk of Cancer.

Am J Gastroenterol 2019 Jan;114(1):155-164

Department of Molecular and Clinical Cancer Medicine, Institute of Translational Medicine, University of Liverpool, Liverpool, L69 3GA, UK.

Objectives: Intraductal papillary mucinous neoplasms (IPMNs) are associated with risk of pancreatic ductal adenocarcinoma (PDAC). It is unclear if an IPMN in individuals at high risk of PDAC should be considered as a positive screening result or as an incidental finding. Stratified familial pancreatic cancer (FPC) populations were used to determine if IPMN risk is linked to familial risk of PDAC. Read More

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http://www.nature.com/articles/s41395-018-0395-y
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http://dx.doi.org/10.1038/s41395-018-0395-yDOI Listing
January 2019
7 Reads

Imaging and Cytopathological Criteria Indicating Malignancy in Mucin-Producing Pancreatic Neoplasms: A Series of 68 Histopathologically Confirmed Cases.

Pancreas 2018 Nov/Dec;47(10):1283-1289

Department of Cytopathology, Aretaieion Hospital, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece.

Objectives: This study aims to evaluate the performance of clinical, imaging, and cytopathological criteria in the identification of high-grade dysplasia/carcinoma (HGD/Ca) in pancreatic mucin-producing cystic neoplasms.

Methods: Sixty-eight consecutive, histopathologically confirmed mucin-producing cystic neoplasms, evaluated by endoscopic ultrasound-guided fine-needle aspiration, were enrolled; specifically, 39 branch duct intraductal papillary mucinous neoplasms (BD-IPMNs), 21 main duct IPMNs, and 8 mucinous cystic neoplasms. The associations between HGD/Ca in histopathology and findings of endoscopic ultrasound and cytology, demographic, lifestyle, and clinical parameters were evaluated, separately in IPMNs and mucinous cystic neoplasms. Read More

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http://Insights.ovid.com/crossref?an=00006676-201811000-0001
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http://dx.doi.org/10.1097/MPA.0000000000001182DOI Listing
March 2019
8 Reads
2.959 Impact Factor

Risk of malignancy in pancreatic cysts with cytology of high-grade epithelial atypia.

Cancer Cytopathol 2018 Sep 26;126(9):773-781. Epub 2018 Sep 26.

Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.

Background: The risk of malignancy is weighed against the attendant risks of surgery in the clinical management of pancreatic cysts. The latter are a group of histologically diverse and prognostically variable entities, and the risk of malignancy therein is primarily based on imaging characteristics-with or without high-grade atypia. Cytologic criteria for high-grade atypia in intraductal papillary mucinous neoplasms have recently been defined, and its recognition in all pancreatic cysts may help to guide management. Read More

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http://doi.wiley.com/10.1002/cncy.22035
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http://dx.doi.org/10.1002/cncy.22035DOI Listing
September 2018
22 Reads

Surgery of Cystic Tumors of the Pancreas - Why, When, and How?

Visc Med 2018 Jul 14;34(3):206-210. Epub 2018 Jun 14.

Department of General, Visceral, and Transplantation Surgery, Ludwig Maximilians-University, Munich, Germany.

The management of cystic pancreatic neoplasms has increasingly gained clinical attention due to their frequent incidental detection by cross-sectional imaging and their potential for progression to pancreatic cancer. Surgical resection is warranted for all mucinous cystic neoplasms, solid pseudopapillary neoplasms, and main-duct intraductal papillary mucinous neoplasms since these lesions harbor a major risk for malignant transformation. For branch-duct IPMN (BD-IPMN), the risk for malignancy is considerably lower so that some lesions may be safely followed while others require surgical resection. Read More

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http://dx.doi.org/10.1159/000489234DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6117660PMC

The "extracapsular cystic" sign in pancreatic serous cystic neoplasms: A clinicopathologic study of 177 patients with cystic pancreatic lesions.

Eur J Radiol 2018 Sep 4;106:167-172. Epub 2018 Aug 4.

Department of Radiology, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China. Electronic address:

Objective: To assess a new imaging feature that we have named the extracapsular cystic sign which can make a constructive contribution towards differentiating serous cystic neoplasms (SCNs) from other pancreatic cystic lesions.

Material And Methods: We retrospectively reviewed 177 CTs/MRIs of patients who underwent pancreatic resection of cystic lesions at two institutions from January 2011/2013, to September 2017. For each patient, demographic information, clinical presentation, especially imaging features were carefully investigated by two experienced abdominal radiologists, retrospectively. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0720048X183027
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http://dx.doi.org/10.1016/j.ejrad.2018.08.002DOI Listing
September 2018
5 Reads

Radiological Workup of Cystic Neoplasms of the Pancreas.

Visc Med 2018 Jul 15;34(3):182-190. Epub 2018 Jun 15.

Department of Radiology, University Medical Center Utrecht, Utrecht, the Netherlands.

Pancreatic cystic lesions are being detected with increasing frequency because of increased use and improved quality of cross-sectional imaging techniques. Pancreatic cystic lesions encompass non-neoplastic lesions (such as pancreatitis-related collections) and neoplastic tumors. Common cystic pancreatic neoplasms include serous cystadenomas, mucinous cystic neoplasms, intraductal papillary mucinous neoplasms, and solid pseudopapillary tumors. Read More

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https://www.karger.com/Article/FullText/489674
Publisher Site
http://dx.doi.org/10.1159/000489674DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6103340PMC
July 2018
10 Reads

Cyst Fluid Biomarkers - Diagnosis and Prediction of Malignancy for Cystic Lesions of the Pancreas.

Visc Med 2018 Jul 13;34(3):178-181. Epub 2018 Jun 13.

Department of Medicine, Surgery, Radiology and Oncology, The Sol Goldman Pancreatic Cancer Research Center, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.

Pancreatic cysts are common, and are identified in 2-13% of individuals undergoing cross-sectional imaging. Intraductal papillary mucinous neoplasms (IPMNs) and mucinous cystic neoplasms (MCNs) are pancreatic cysts which are precursors to pancreatic adenocarcinoma. Currently available tools are imperfect at differentiating IPMNs and MCNs from other, benign types of pancreatic cysts. Read More

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http://dx.doi.org/10.1159/000490137DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6103364PMC

New horizons in the endoscopic ultrasonography-based diagnosis of pancreatic cystic lesions.

World J Gastroenterol 2018 Jul;24(26):2853-2866

Department of Gastroenterology, Ramsay Générale de Santé Private Hospital Jean Mermoz, Lyon 69008, France.

Pancreatic cystic lesions (PCLs) are increasingly being identified because of the widespread use of high-resolution abdominal imaging. These cysts encompass a spectrum from malignant disease to benign lesions, and therefore, accurate diagnosis is crucial to determine the best management strategy, either surgical resection or surveillance. However, the current standard of diagnosis is not accurate enough due to limitations of imaging and tissue sampling techniques, which entail the risk of unnecessary burdensome surgery for benign lesions or missed opportunities of prophylactic surgery for potentially malignant PCLs. Read More

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http://dx.doi.org/10.3748/wjg.v24.i26.2853DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6048425PMC
July 2018
17 Reads

Does cyst growth predict malignancy in branch duct intraductal papillary mucinous neoplasms? Results of a large multicenter experience.

Dig Liver Dis 2018 Sep 27;50(9):961-968. Epub 2018 Apr 27.

Division of Gastroenterology, Indiana University School of Medicine, Indianapolis, IN, USA. Electronic address:

Background: Cyst growth of BD-IPMNs on follow-up imaging remains a concerning sign.

Aims: To describe cyst size changes over time in BD-IPMNs, and determine whether cyst growth rate is associated with increased risk of malignancy.

Methods: This is a retrospective study performed at two high volume tertiary centers. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S15908658183071
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http://dx.doi.org/10.1016/j.dld.2018.04.022DOI Listing
September 2018
28 Reads

Clinical Impact of KRAS and GNAS Analysis Added to CEA and Cytology in Pancreatic Cystic Fluid Obtained by EUS-FNA.

Dig Dis Sci 2018 09 24;63(9):2351-2361. Epub 2018 May 24.

Faculty of Medicine, University of Lisbon, Lisbon, Portugal.

Background: Pancreatic cysts are common incidental findings with malignant potential, raising diagnostic and treatment dilemmas.

Aims: To determine the added value of KRAS and GNAS mutation analysis on cyst classification and decision making.

Methods: We analyzed 52 frozen samples of pancreatic cystic fluid obtained by EUS-FNA between 2008 and 2014. Read More

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http://dx.doi.org/10.1007/s10620-018-5128-yDOI Listing
September 2018
5 Reads
2.550 Impact Factor

Clinical significance of pancreatic intraepithelial neoplasia in resectable pancreatic cancer on survivals.

Ann Surg Treat Res 2018 May 30;94(5):247-253. Epub 2018 Apr 30.

Department of Pathology, Korea University College of Medicine, Seoul, Korea.

Purpose: Noninvasive precursor lesions for pancreatic adenocarcinoma include pancreatic intraepithelial neoplasia (PanIN), intraductal papillary mucinous neoplasm, and mucinous cystic neoplasm. PanIN is often found synchronously adjacent to resected pancreatic ductal adenocarcinoma (PDAC) tumors. However, its prognostic significance on outcome after PDAC resection is unknown. Read More

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http://dx.doi.org/10.4174/astr.2018.94.5.247DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5931935PMC
May 2018
1 Read

Predictors of Malignancy in "Pure" Branch-Duct Intraductal Papillary Mucinous Neoplasm of the Pancreas without Enhancing Mural Nodules on CT Imaging: A Nationwide Multicenter Study.

Gut Liver 2018 09;12(5):583-590

Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.

Background/aims: Presence of enhanced mural nodules, which can be visualized using computed tomography (CT), is one of high-risk stigmata in branch-duct intraductal papillary mucinous neoplasms (BD-IPMNs). Conversely, the absence of enhanced mural nodules on preoperative imaging does not exclude malignant risk. The present study aimed to investigate other morphological features as predictors of malignancy in "pure" BD-IPMNs without enhanced mural nodules on CT. Read More

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http://dx.doi.org/10.5009/gnl17582DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6143451PMC
September 2018
18 Reads

Concurrent presentation of an intraductal tubulopapillary neoplasm and intraductal papillary mucinous neoplasm in the branch duct of the pancreas, with a superior mesenteric artery aneurysm: a case report.

World J Surg Oncol 2018 Apr 24;16(1):83. Epub 2018 Apr 24.

Department of Surgery, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo, 160-8582, Japan.

Background: Since the concept of intraductal tubulopapillary neoplasm (ITPN) was introduced in the current World Health Organization classification of tumors, the number of reports of ITPN occurrence has increased gradually. However, ITPN is usually located in the main pancreatic duct, with few reports of a branch duct ITPN. As a result, imaging protocols for the diagnosis of a branch duct ITPN have not been established. Read More

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https://wjso.biomedcentral.com/articles/10.1186/s12957-018-1
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http://dx.doi.org/10.1186/s12957-018-1391-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5913796PMC
April 2018
9 Reads

Diagnostic Accuracy of Preoperative Imaging for Differentiation of Branch Duct Versus Mixed Duct Intraductal Papillary Mucinous Neoplasms.

Pancreas 2018 May/Jun;47(5):556-560

Objective: The aim of this study is to determine the diagnostic accuracy of preoperative evaluation to detect main pancreatic duct involvement in pancreatic cystic lesions thus differentiating mixed intraductal papillary mucinous neoplasm (IPMN) from branch duct (BD)-IPMN.

Methods: The pathology database of pancreatic resections from 2000 to 2014 was reviewed. Main pancreatic duct-IPMNs and IPMNs with intracystic mass/nodules were excluded. Read More

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http://dx.doi.org/10.1097/MPA.0000000000001040DOI Listing
October 2018
9 Reads
2.960 Impact Factor

Epidermoid cyst within an intrapancreatic accessory spleen.

BMJ Case Rep 2018 Apr 5;2018. Epub 2018 Apr 5.

Division of Surgical Oncology, Department of Surgery, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA.

This is a case of an epidermoid cyst in an intrapancreatic accessory spleen at the tail of the pancreas. Concurrent epidermoid cyst within the accessory spleen is an exceedingly rare entity. The patient initially presented with abdominal pain, nausea and vomiting. Read More

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http://dx.doi.org/10.1136/bcr-2017-223600DOI Listing
April 2018
3 Reads

[Pancreatic mucinous cystadenoma doubly complicated by acute pancreatitis and retroperitoneal rupture].

Pan Afr Med J 2017 6;28:203. Epub 2017 Nov 6.

Département de Chirurgie, Hôpital La Rabta, Faculté de Médecine de Tunis, Tunis, Tunisie.

Mucinous cystadenomas are benign tumors with malignant potential. They are often revealed by non-specific abdominal pain, jaundice or an episode of acute pancreatitis. We here report an exceptional case of mucinous cystadenoma doubly complicated by acute pancreatitis and retroperitoneal rupture. Read More

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http://dx.doi.org/10.11604/pamj.2017.28.203.13715DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5878853PMC
May 2018
1 Read

Progression Patterns in the Remnant Pancreas after Resection of Non-Invasive or Micro-Invasive Intraductal Papillary Mucinous Neoplasms (IPMN).

Ann Surg Oncol 2018 Jun 27;25(6):1752-1759. Epub 2018 Mar 27.

Department of Surgery, Hepatopancreatobiliary Service, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

Background: Although IPMN are thought to represent a whole-gland disease, segmental resection remains the most frequently performed treatment. We sought to determine the rates, patterns, and predictors of IPMN progression in the pancreatic remnant following segmental resection of noninvasive or microinvasive IPMN.

Methods: A prospectively maintained database was queried to identify all patients who underwent resection of noninvasive or microinvasive IPMN (≤ 10 mm of invasive component) between 1989 and 2015. Read More

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http://link.springer.com/10.1245/s10434-018-6445-2
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http://dx.doi.org/10.1245/s10434-018-6445-2DOI Listing
June 2018
19 Reads

Neuroendocrine neoplasm of pancreas with cystic degeneration mimicking mucinous cystic neoplasm.

Clin J Gastroenterol 2018 Aug 13;11(4):333-337. Epub 2018 Mar 13.

Department of Gastroenterology and Hepatology, Nagoya University Graduate School of Medicine, Aichi, Japan.

Endoscopic ultrasound is increasingly being used for evaluation of pancreatic diseases and pancreatic tumors. Among various pancreatic cystic lesions, cystic degeneration of pancreatic neuroendocrine neoplasm is of the challenge in making diagnosis. Although unique characteristic of each type of pancreatic cystic lesions has been proposed abundantly, typical morphology of cystic degeneration of pancreatic neuroendocrine neoplasm is still unclear. Read More

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http://dx.doi.org/10.1007/s12328-018-0846-4DOI Listing
August 2018
1 Read

[Surgical Resection of an Intraductal Papillary Mucinous Carcinoma Observed on Imaging Four Years after the Initial Diagnosis].

Gan To Kagaku Ryoho 2018 Feb;45(2):269-272

Dept. of Surgery, Keiyu Hospital.

We herein report a 75-year-old woman who presented with an intraductal papillary mucinous carcinoma(IPMC)who was treated with surgical resection 4 years after the initial diagnosis was made. She previously underwent a high anterior resection of the rectum for rectal cancer at 71 years of age. Preoperative CT revealed a multilocular cystic mass measuring 6 cm in size in the body of the pancreas, which was considered benign. Read More

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February 2018
3 Reads

Resection of benign side-branch intraductal papillary mucinous neoplasm of the pancreas-is long term follow-up indicated?: A case report and review of the literature.

Medicine (Baltimore) 2018 Feb;97(7):e9894

Rationale: Intraductal papillary mucinous neoplasms of the pancreas (IPMNs) are benign cystic tumors with a relevant risk of malignant transformation over time. Currently, follow-up after surgical resection of benign IPMNs remains controversial.

Patient Concerns: This is a case report of a 68-year-old male who underwent pancreatic head resection for a multicystic side-branch IPMN with low-grade epithelial dysplasia in March 2009 at the Katharinenhospital Stuttgart, Germany. Read More

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http://dx.doi.org/10.1097/MD.0000000000009894DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5839808PMC
February 2018
5 Reads

[Simple mucinous cyst of the pancreas: Case-report and literature review].

Ann Pathol 2018 Apr 4;38(2):137-142. Epub 2018 Feb 4.

Service d'anatomie et cytologie pathologiques, hôpital Saint-Antoine, 184, rue du Faubourg-Saint-Antoine, 75571 Paris cedex 12, France. Electronic address:

Simple mucinous cyst of the pancreas is an unusual pancreatic cyst, first described by Kosmahl et al. in 2002 with 5 cases. We describe a case of simple mucinous cyst of the pancreas, followed by a literature review. Read More

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http://dx.doi.org/10.1016/j.annpat.2017.12.004DOI Listing

Current concepts in molecular genetics and management guidelines for pancreatic cystic neoplasms: an essential update for radiologists.

Abdom Radiol (NY) 2018 Sep;43(9):2351-2368

Department of Radiology, University of Pittsburgh Medical Center, Radiology Suite 200 East Wing E2051B, 200 Lothrop Street, Pittsburgh, PA, 15213, USA.

Cystic neoplasms in the pancreas are encountered frequently on imaging, often detected incidentally during evaluation for other conditions. They can have a variety of clinical and imaging presentations, and similarly, wide-ranging prognostic and treatment implications. In the majority, imaging helps in diagnosis of pancreatic cystic neoplasms (PCNs) and guides management decisions. Read More

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http://dx.doi.org/10.1007/s00261-017-1452-5DOI Listing
September 2018
14 Reads

Imaging Follow-up of Low-Risk Incidental Pancreas and Kidney Findings: Effects of Patient Age and Comorbidity on Projected Life Expectancy.

Radiology 2018 05 5;287(2):504-514. Epub 2018 Feb 5.

From the Department of Radiology (T.J.R., D.T.W., A.B.K., P.V.P.) and Institute for Technology Assessment (T.J.R., D.T.W., A.B.K., P.V.P.), Massachusetts General Hospital, 101 Merrimac St, 10th Floor, Boston, MA 02114; Department of Radiology, University of Alabama at Birmingham, Birmingham, Ala (L.L.B.); Department of Radiology, Cleveland Clinic, Cleveland, Ohio (B.R.H.); and Department of Radiology, NYU-Langone Medical Center, New York, NY (A.J.M.).

Purpose To determine the effects of patient age and comorbidity level on life expectancy (LE) benefits associated with imaging follow-up of Bosniak IIF renal cysts and pancreatic side-branch (SB) intraductal papillary mucinous neoplasms (IPMNs). Materials and Methods A decision-analytic Markov model to evaluate LE benefits was developed. Hypothetical cohorts with varied age (60-80 years) and comorbidities (none, mild, moderate, or severe) were evaluated. Read More

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http://dx.doi.org/10.1148/radiol.2018171701DOI Listing
May 2018
6 Reads

Bleeding from isolated gastric varices as complication of a mucinous cystic neoplasm of the pancreas: A case report.

Medicine (Baltimore) 2017 Nov;96(47):e8775

Department of Surgery, University of Medicine and Pharmacy "Grigore T. Popa".

Introduction: Bleeding from isolated gastric varices, though uncommon, may be life threatening and may occur as a consequence of splenic vein thrombosis by tumoral compression and subsequent left-sided portal hypertension.

Case Overview: We report the case of a 37-year old woman, previously diagnosed with a benign pancreatic cyst, who presented with severe gastric variceal bleeding.

Diagnosis, Therapeutics Interventions, And Outcomes: Abdominal ultrasound (US) and computed-tomography (CT) revealed enlargement and changed morphology of the cystic tumor located on the body of the pancreas. Read More

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http://Insights.ovid.com/crossref?an=00005792-201711270-0006
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http://dx.doi.org/10.1097/MD.0000000000008775DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5708976PMC
November 2017
18 Reads

Mass forming chronic pancreatitis mimicking pancreatic cystic neoplasm: A case report.

Authors:
Keum Nahn Jee

World J Gastroenterol 2018 Jan;24(2):297-302

Department of Radiology, Dankook University Hospital, Chungcheongnam-do 330-715, South Korea.

Mass forming chronic pancreatitis is very rare. Diagnosis could be done by the pathologic findings of focal inflammatory fibrosis without evidence of tumor in pancreas. A 34-year-old man presented with right upper abdominal pain for a few weeks and slightly elevated bilirubin level on clinical findings. Read More

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http://dx.doi.org/10.3748/wjg.v24.i2.297DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5768948PMC
January 2018
14 Reads

Prevalence and outcomes of pancreatic cystic neoplasms in liver transplant recipients.

World J Gastroenterol 2017 Dec;23(48):8526-8532

AW Morrow Gastroenterology and Liver Centre, Royal Prince Alfred Hospital, Camperdown, NSW 2050, Australia

Aim: To determine the prevalence, characteristics and clinical course of pancreatic cystic neoplasms (PCNs) in liver transplantation (LT) recipients.

Methods: We retrospectively studied consecutive patients who underwent LT between January 1998 to April 2016. Clinical and laboratory data were obtained from patient medical records. Read More

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http://www.wjgnet.com/1007-9327/full/v23/i48/8526.htm
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http://dx.doi.org/10.3748/wjg.v23.i48.8526DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5752712PMC
December 2017
11 Reads

Intraductal Papillary Mucinous Neoplasms of the Pancreas: Strategic Considerations.

Visc Med 2017 Dec 8;33(6):466-476. Epub 2017 Dec 8.

Department of Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.

Intraductal papillary mucinous neoplasms (IPMN) are cystic neoplasms with the potential for progression to pancreatic cancer. Recognized by the global medical community just over two decades ago, IPMN have gained great epidemiological and clinical relevance thanks to the widespread use of cross-sectional abdominal imaging, which has led to a surge in the number of incidental pancreatic cysts being diagnosed. As our understanding of this disease has improved, we now know that some IPMN have a very elevated risk of cancer and require surgical resection, while others are low-risk lesions and can be followed. Read More

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http://dx.doi.org/10.1159/000485014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5757605PMC
December 2017
7 Reads

Agreement among Magnetic Resonance Imaging/Magnetic Resonance Cholangiopancreatography (MRI-MRCP) and Endoscopic Ultrasound (EUS) in the evaluation of morphological features of Branch Duct Intraductal Papillary Mucinous Neoplasm (BD-IPMN).

Pancreatology 2018 Mar 4;18(2):170-175. Epub 2018 Jan 4.

Gastroenterology Department, Complejo Hospitalario Universitario de Santiago de Compostela, Santiago de Compostela, Spain. Electronic address:

Background/objectives: To evaluate the agreement between the imaging modalities MRI-MRCP and EUS in cystic lesions of the pancreas which were thought to be a BD-IPMN.

Methods: Multicenter retrospective study included all patients between 2010 and 2015 with a suspected BD-IPMN who underwent an EUS and MRI-MRCP within 6 months or less of each other. Location, number, size, worrisome features and high-risk stigmata were evaluated. Read More

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http://dx.doi.org/10.1016/j.pan.2018.01.002DOI Listing
March 2018
5 Reads

[The current status of diagnosis and treatment of pancreatic cystic neoplasm in China: a report of 2 251 cases].

Authors:

Zhonghua Wai Ke Za Zhi 2018 Jan;56(1):24-29

To analyze the current status of diagnosis and treatment of pancreatic cystic neoplasm(PCN)in China. Clinical data of 2 251 PCN patients who underwent surgical resection from January 2006 to December 2016 in 16 institutions was retrospectively analyzed.Excel database was created which covered 132 fields of 7 fields: general information of patients, imaging findings, preoperative blood biochemical indexes, tumor markers, surgical related data, postoperative complications and pathology. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0529-5815.2018.01.007DOI Listing
January 2018
2 Reads

Pancreas ductal adenocarcinoma with cystic features on cross-sectional imaging: radiologic-pathologic correlation.

Diagn Interv Radiol 2018 Jan-Feb;24(1):5-11

Department of Internal Medicine, Seoul St. Mary's Hospital, The Catholic University of Korea College of Medicine, Seoul, Korea; Hepato-Biliary-Pancreatic Cancer Center, Seoul St. Mary's Hospital, The Catholic University of Korea College of Medicine, Seoul, Korea; Cancer Research Institute, The Catholic University of Korea College of Medicine, Seoul, South Korea.

Most pancreatic ductal adenocarcinomas (PDAs) show solid growth pattern, but ductal adenocarcinomas may demonstrate intratumoral cystic appearance or accompany peritumoral non-neoplastic cystic lesions, thus mimicking cystic pancreatic tumors on imaging studies. The histopathologic findings for PDA with cystic feature are divided into neoplastic and non-neoplastic cysts. Neoplastic cystic changes include large-duct type cysts (microcystic appearance), neoplastic mucin cysts (macrocystic appearance), colloid carcinomas (mucinous noncystic adenocarcinomas), and degenerative cystic change usually caused by hemorrhagic necrosis of tumor. Read More

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http://www.dirjournal.org/eng/makale/1779/93/Full-Text
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http://dx.doi.org/10.5152/dir.2018.17250DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5765930PMC
August 2018
7 Reads

Diagnosis, morphopathological profile and treatment of mucinous cystadenoma of the pancreas - a single center experience.

Rom J Morphol Embryol 2018 ;59(4):1155-1163

Center of General Surgery and Liver Transplantation, "Fundeni" Clinical Institute, Bucharest, Romania;

Aim: Pancreatic mucinous cystadenoma (MCA) occurs almost exclusively in perimenopausal women and represents between 10% and 45% of cystic neoplasm of the pancreas, being considered a premalignant lesion.

Materials And Methods: From 1983 to 2017, 31 patients underwent surgery for MCA of the pancreas in our Center. The median age was 47 years (range 17-81 years). Read More

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April 2019
2 Reads

Loss of Pten and Activation of Kras Synergistically Induce Formation of Intraductal Papillary Mucinous Neoplasia From Pancreatic Ductal Cells in Mice.

Gastroenterology 2018 04 19;154(5):1509-1523.e5. Epub 2017 Dec 19.

Departments of Pediatrics and Cellular and Molecular Medicine, University of California-San Diego, La Jolla, California. Electronic address:

Background & Aims: Intraductal papillary mucinous neoplasias (IPMNs) are precancerous cystic lesions that can develop into pancreatic ductal adenocarcinomas (PDACs). These large macroscopic lesions are frequently detected during medical imaging, but it is unclear how they form or progress to PDAC. We aimed to identify cells that form IPMNs and mutations that promote IPMN development and progression. Read More

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http://dx.doi.org/10.1053/j.gastro.2017.12.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5880733PMC
April 2018
21 Reads

Spyglass-guided pancreatic stent placement for intraductal papillary mucinous neoplasm with recurrent pancreatitis.

Dig Liver Dis 2018 May 24;50(5):513. Epub 2017 Nov 24.

Department of Gastroenterology, Changhai Hospital, Second Military Medical University, Shanghai, China. Electronic address:

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http://dx.doi.org/10.1016/j.dld.2017.11.009DOI Listing
May 2018
7 Reads

Vanishing Pancreatic Cysts during Follow-Up: Another Step Towards De-Emphasizing Cyst Size as a Major Clinical Predictor of Malignancy.

Dig Surg 2018 12;35(6):508-513. Epub 2017 Dec 12.

Department of General and Pancreatic Surgery, The Pancreas Institute, University of Verona Hospital Trust, Verona, Italy.

Introduction: In the management of pancreatic cystic neoplasms (PCN), size plays a crucial role as the expression of disease progression. While many evidences regarding the natural history of growing pancreatic cysts exist, almost no data are available regarding cysts with a reduction in size.

Methods: Radiological and clinical data from patients of the dedicated pancreatic cysts outpatient clinic of the Department of General and Pancreatic Surgery, University of Verona Hospital were retrospectively reviewed. Read More

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http://dx.doi.org/10.1159/000485199DOI Listing
January 2019
5 Reads

The association of pancreatic cystosis and IPMN in cystic fibrosis: case report and literature review.

Eur Rev Med Pharmacol Sci 2017 Nov;21(22):5179-5184

Department of Internal Medicine and Gastroenterology, Pancreatic Unit, Fondazione Policlinico Universitario "A. Gemelli", Catholic University of the Sacred Heart, School of Medicine, Rome, Italy.

Pancreatic cystosis is a rare presentation of cystic fibrosis involving pancreatic gland. To date, only very few cases of pancreatic cystosis have been described in literature. Pancreatic cystosis may begin during the second decade of life and is the rarest presentation of cystic fibrosis. Read More

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http://dx.doi.org/10.26355/eurrev_201711_13837DOI Listing
November 2017
3 Reads

[A case of non-invasive IPMC with fibrotic lesion-like "tubular complex"].

Nihon Shokakibyo Gakkai Zasshi 2017;114(12):2142-2150

Department of Gastroenterology, National Hospital Organization Sendai Medical Center.

A 73-year-old man was incidentally diagnosed with a cystic lesion in the pancreatic body. Ultrasonography, abdominal computed tomography, magnetic resonance imaging, endoscopic retrograde cholangiopancreatography, and endoscopic ultrasound were performed, and a nodule was detected in the cystic lesion along with an irregularity of the main pancreatic duct. An initial diagnosis of a mixed-type intraductal papillary mucinous neoplasm was made, and a central pancreatectomy was performed. Read More

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http://dx.doi.org/10.11405/nisshoshi.114.2142DOI Listing
June 2018
3 Reads

Outcomes of endoscopic ultrasound-guided pancreatic FNAC diagnosis for solid and cystic lesions at Manchester Royal Infirmary based upon the Papanicolaou Society of Cytopathology pancreaticobiliary terminology classification scheme.

Cytopathology 2018 02 29;29(1):71-79. Epub 2017 Nov 29.

Manchester Cytology Centre, Manchester Royal Infirmary, Manchester University NHS Foundation Trust, Manchester, UK.

Objective: To compare endoscopic ultrasound (EUS)-FNAC diagnosis of pancreatic lesions with patient outcome based upon the Papanicolaou Society of Cytopathology pancreaticobiliary terminology classification scheme diagnostic categories: Panc 1 (non-diagnostic); Panc 2 (negative for malignancy/neoplasia); Panc 3 (atypical); Panc 4B (neoplastic, benign); Panc 4O (neoplastic, other); Panc 5 (suspicious of malignancy); and Panc 6 (positive/malignant).

Methods: All EUS-FNA pancreas specimens taken at Manchester Royal Infirmary in 2015 were prospectively classified according to the above scheme at the time of cytology reporting and data recorded prospectively. Subsequently, outcomes based on clinical follow-up or histopathology diagnosis were compared with the cytology diagnosis. Read More

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http://dx.doi.org/10.1111/cyt.12502DOI Listing
February 2018

Identification of a pyruvate-to-lactate signature in pancreatic intraductal papillary mucinous neoplasms.

Pancreatology 2018 Jan 14;18(1):46-53. Epub 2017 Nov 14.

Department of Molecular Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA; Department of Radiology, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA. Electronic address:

Objective: We used transcriptomic profiling and immunohistochemistry (IHC) to search for a functional imaging strategy to resolve common problems with morphological imaging of cystic neoplasms and benign cystic lesions of the pancreas.

Methods: Resected pancreatic cancer (n = 21) and normal pancreas were laser-capture micro-dissected, and transcripts were quantified by RNAseq. Functional imaging targets were validated at the protein level by IHC on a pancreatic adenocarcinoma tissue microarray and a newly created tissue microarray of resected intraductal papillary mucinous neoplasms (IPMNs) and IPMN-associated adenocarcinomas. Read More

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http://dx.doi.org/10.1016/j.pan.2017.11.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6139027PMC
January 2018
12 Reads

Progression of Pancreatic Branch Duct Intraductal Papillary Mucinous Neoplasm Associates With Cyst Size.

Gastroenterology 2018 02 23;154(3):576-584. Epub 2017 Oct 23.

Department of Surgery and Cancer Research Institute, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Korea. Electronic address:

Backgrounds & Aims: Most guidelines for management of patients with intraductal papillary mucinous neoplasms (IPMN) vary in proposed surveillance intervals and durations-these are usually determined based on expert opinions rather than substantial evidence. The progression of and optimal surveillance intervals for branch-duct IPMNs (BD-IPMN) has not been widely studied. We evaluated the progression of BD-IPMN under surveillance at a single center, and determined optimal follow-up intervals and duration. Read More

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http://dx.doi.org/10.1053/j.gastro.2017.10.013DOI Listing
February 2018
18 Reads

Prevalence and outcomes of cystic lesions of the transplant pancreas: The University of Wisconsin Experience.

Am J Transplant 2018 02 15;18(2):467-477. Epub 2017 Nov 15.

Division of Transplantation, Department of Surgery, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.

Literature on the behavior of cystic lesions in pancreas transplants is scarce, and hence a better understanding is warranted. Data on recipients and their respective donors that underwent simultaneous kidney and pancreas, pancreas transplant alone, and pancreas after kidney between 1994 and 2015 were reviewed (n = 1185). Cystic lesions of the transplant pancreas developed in 22 patients (1. Read More

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http://dx.doi.org/10.1111/ajt.14540DOI Listing
February 2018
18 Reads

Mucinous cystic neoplasms of the pancreas: high-resolution cross-sectional imaging features with clinico-pathologic correlation.

Abdom Radiol (NY) 2018 Jun;43(6):1413-1422

Division of Abdominal Imaging, Department of Radiology, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue - Ansin 235, Boston, MA, 02115, USA.

Purpose: To describe the high-resolution cross-sectional (MDCT/MRI) features of mucinous cystic neoplasms (MCN) of the pancreas with clinico-pathologic correlation; to identify imaging predictors of high-grade dysplasia/carcinoma; and to estimate MCN growth rate.

Materials And Methods: Thirty-two women (mean age: 46; range, 25-79 years) with resected MCN who underwent preoperative MDCT (n = 20) or MRI (n = 12) examinations over a 14-year period were included. Two radiologists examined retrospectively in consensus the following MDCT/MRI features: MCN location, size/volume, presence of capsule and thickness of the capsule, and presence of mural nodules, enhancing septations, calcifications, chronic pancreatitis, and main pancreatic duct dilation. Read More

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http://link.springer.com/10.1007/s00261-017-1326-x
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http://dx.doi.org/10.1007/s00261-017-1326-xDOI Listing
June 2018
15 Reads

Endoscopic Ultrasound Imaging for Diagnosing and Treating Pancreatic Cysts.

Gastrointest Endosc Clin N Am 2017 Oct 12;27(4):615-642. Epub 2017 Aug 12.

Division of Gastroenterology and Hepatology, Indiana University School of Medicine, 550 North University Boulevard, Suite 4100, Indianapolis, IN 46202, USA. Electronic address:

Cystic pancreatic lesions are increasingly diagnosed owing to the abundant use of cross-sectional imaging. Given their malignant potential, true pancreatic cysts should be considered for resection or periodic follow-up. Cystic lesions of the pancreas (CLPs) require further evaluation and management. Read More

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http://dx.doi.org/10.1016/j.giec.2017.06.004DOI Listing
October 2017
6 Reads