828 results match your criteria Imaging in Mucinous Cystic Neoplasms of the Pancreas

Automated Detection of Pancreatic Cystic Lesions on CT Using Deep Learning.

Diagnostics (Basel) 2021 May 19;11(5). Epub 2021 May 19.

Clinic of Radiology & Nuclear Medicine, University Hospital Basel, University of Basel, Petersgraben 4, 4031 Basel, Switzerland.

Pancreatic cystic lesions (PCL) are a frequent and underreported incidental finding on CT scans and can transform into neoplasms with devastating consequences. We developed and evaluated an algorithm based on a two-step nnU-Net architecture for automated detection of PCL on CTs. A total of 543 cysts on 221 abdominal CTs were manually segmented in 3D by a radiology resident in consensus with a board-certified radiologist specialized in abdominal radiology. Read More

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Pancreatic cystic neoplasms and post-inflammatory cysts: interobserver agreement and diagnostic performance of MRI with MRCP.

Abdom Radiol (NY) 2021 May 20. Epub 2021 May 20.

Department of Radiology and Imaging Sciences, Indiana University School of Medicine, 550 N. University Blvd UH 0663, Indianapolis, IN, 46202, USA.

Purpose: We aimed to answer several clinically relevant questions; (1) the interobserver agreement, (2) diagnostic performance of MRI with MRCP for (a) branch duct intraductal papillary mucinous neoplasms (BD-IPMN), mucinous cystic neoplasms (MCN) and serous cystic neoplasms (SCN), (b) distinguishing mucinous (BD-IPMN and MCN) from non-mucinous cysts, and (c) distinguishing three pancreatic cystic neoplasms (PCN) from post-inflammatory cysts (PIC).

Methods: A retrospective analysis was performed at a tertiary referral center for pancreatic diseases on 71 patients including 44 PCNs and 27 PICs. All PCNs were confirmed by surgical pathology to be 17 BD-IPMNs, 13 MCNs, and 14 SCNs. Read More

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Multiparameter Analysis Using F-FDG PET/CT in the Differential Diagnosis of Pancreatic Cystic Neoplasms.

Contrast Media Mol Imaging 2021 7;2021:6658644. Epub 2021 Apr 7.

Department of Nuclear Medicine, The First Medical Centre, Chinese PLA General Hospital, Fuxing Road 28, Beijing 100853, China.

Purpose: To evaluate multiparametric analysis in differential diagnosis between pancreatic serous cystic neoplasms (SCNs) and mucinous cystic neoplasms (MCNs) as well as the differentiation of the benign and malignant MCNs with F-FDG (18-fluorodeoxyglucose) PET/CT (positron emission tomography).

Methods: Forty patients with total of 41 lesions (SCNs: 27/41; MCNs: 14/41), who were preoperatively examined with F-FDG PET/CT, were retrospectively analyzed. Multiple quantitative parameters using conventional and texture features were included. Read More

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A case of intraductal tubulopapillary neoplasm of the pancreas in a branch duct: a rare case report and literature review.

BMC Gastroenterol 2021 Apr 13;21(1):162. Epub 2021 Apr 13.

Department of Gastroenterology, National Hospital Organization Kure Medical Center and Chugoku Cancer Center, Kure, Hiroshima Prefecture, Japan.

Background: Intraductal tubulopapillary neoplasm (ITPN) of the pancreas is a new disease concept defined by the World Health Organization in 2010. ITPN progresses with tubulopapillary growth in the pancreatic duct and is known to have a fair prognosis. Localization in the main pancreatic duct (MPD) is one characteristic. Read More

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Pancreatic cystic neoplasms: a review of current recommendations for surveillance and management.

Abdom Radiol (NY) 2021 Mar 20. Epub 2021 Mar 20.

Case Western Reserve University School of Medicine, 2109 Adelbert Road, Cleveland, OH, USA.

Pancreatic cystic neoplasms (PCN) comprise of a diverse array of pancreatic cysts, including intraductal papillary mucinous neoplasms (IPMN), mucinous cystic neoplasms (MCN), serous cystic neoplasms (SCN), cystic neuroendocrine tumors (cNET), and many others. Increasing use of cross-sectional imaging has resulted in greater numbers of PCNs discovered incidentally. The overall risk of malignancy is low, but can vary considerably between different classes of PCNs. Read More

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Lactoferrin amyloid presenting as a mural nodule in a pancreatic cystic lesion prompting pancreatoduodenectomy: a case report.

BMC Gastroenterol 2021 Feb 12;21(1):66. Epub 2021 Feb 12.

Department of Pathology and Immunology, Baylor College of Medicine, 1 Baylor Plaza, MS BCM315, Houston, TX, 77030, USA.

Background: Amyloid deposition in pancreas is rare. Lactoferrin amyloid deposition has not been reported in pancreas, till date. Presence of enhancing mural nodule in a cyst on imaging is a worrisome feature for malignancy, and warrants surgical resection in a surgically fit candidate, as per Fukuoka guidelines for management of cystic lesions in pancreas. Read More

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February 2021

Triple threat: pancreatic cystic lesion presenting with spontaneous hemorrhage is found to harbor three distinct neoplasms.

World J Surg Oncol 2021 Jan 15;19(1):15. Epub 2021 Jan 15.

HPB Surgery and Surgical Oncology, Valley Medical Group, Luckow Plaza, One Valley Health Plaza, Paramus, NJ, 07652, USA.

Background: Pancreatic serous cystadenoma (SCA) is a benign, cystic lesion with an indolent growth pattern. Complications such as spontaneous hemorrhage or malignant transformation from SCA are extremely rare. Our case report describes an unusual presentation of a patient with a previously diagnosed SCA, made unique by the presence of three separate neoplasms in the final specimen. Read More

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January 2021

Mucin-filled CBD, difficult to manage cholangitis.

BMJ Case Rep 2021 Jan 11;14(1). Epub 2021 Jan 11.

Gastroenterology, GB Pant Hospital, New Delhi, India

Intraductal papillary mucinous neoplasms (IPMNs) are mucin-secreting cystic neoplasm of pancreas. They have a malignant potential. They are usually localised to the pancreas but occasionally can involve surrounding structures (1. Read More

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January 2021

Cystic biliary tumors of the liver: diagnostic criteria and common pitfalls.

Hum Pathol 2021 Jun 28;112:70-83. Epub 2020 Dec 28.

Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA. Electronic address:

With major advancements and frequent use of abdominal imaging techniques, hepatic cysts are increasingly encountered in clinical practice. Although the majority of cysts are benign, a small subset represents neoplastic precursors to cholangiocarcinoma. These cystic precursors include intraductal papillary neoplasms of the bile duct (IPNB) and mucinous cystic neoplasms of the liver (MCN-L), and bear striking pathologic resemblance to corresponding cystic neoplastic precursors within the pancreas. Read More

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Magnetic resonance (MR) for mural nodule detection studying Intraductal papillary mucinous neoplasms (IPMN) of pancreas: Imaging-pathologic correlation.

Pancreatology 2021 Jan 3;21(1):180-187. Epub 2020 Dec 3.

Department of Surgery, G.B. Rossi Hospital, University of Verona, Piazzale L.A. Scuro 10, 37134, Verona, Italy.

Purpose: Magnetic Resonance (MR) is recommended to diagnose Intraductal Papillary Mucinous Neoplasms (IPMN) and in the follow-up of borderline lesions. The purpose of this work is to evaluate the diagnostic accuracy of dynamic MR with Diffusion Weighted Imaging (DWI) in the identification of mural nodules of pancreatic IPMN by using pathological analysis as gold standard.

Materials And Methods: Ninety-one preoperative MR with histopathological diagnosis of IPMN were reviewed by two radiologists. Read More

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January 2021

Sonographic characteristics and follow-up of pancreatic cysts.

J Clin Ultrasound 2021 Mar 10;49(3):184-188. Epub 2020 Dec 10.

Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.

Objectives: To assess sonographic characteristics and outcome of patients with pancreatic cystic lesions seen by ultrasound.

Methods: From our ultrasound electronic reporting database we identified all patients in which "pancreatic cyst" or "pancreatic cysts" were reported from 1995 to 2018. In patients with more than one sonogram, the first was used for our study. Read More

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Differentiating benign from malignant pancreatic cysts on computed tomography.

Eur J Radiol Open 2020 1;7:100278. Epub 2020 Nov 1.

Second Affiliated Hospital, Department of Radiology, Sun Yat-sen University, Guangzhou 510000, China.

Purpose: It is important to identify features on computed tomography (CT) that can distinguish between benign and premalignant or malignant pancreatic cysts to avoid unnecessary surgeries. This study investigated the preoperative diagnostic evaluation of cystic pancreatic lesions to determine how advanced imaging and clinical factors should guide management.

Methods: In total, 53 patients with 27 benign and 26 premalignant or malignant cysts were enrolled. Read More

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November 2020

Establishing a living biobank of patient-derived organoids of intraductal papillary mucinous neoplasms of the pancreas.

Lab Invest 2021 02 9;101(2):204-217. Epub 2020 Oct 9.

Department of Gastrointestinal Oncology, Moffitt Cancer Center and Research Institute, Tampa, FL, USA.

Pancreatic cancer (PaCa) is the third leading cause of cancer-related deaths in the United States. There is an unmet need to develop strategies to detect PaCa at an early, operable stage and prevent its progression. Intraductal papillary mucinous neoplasms (IPMNs) are cystic PaCa precursors that comprise nearly 50% of pancreatic cysts detected incidentally via cross-sectional imaging. Read More

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February 2021

Pancreatic mesothelial cyst.

BMJ Case Rep 2020 Oct 7;13(10). Epub 2020 Oct 7.

Department of General Surgery, Notre Dame des Secours University Hospital Center, Jbeil, Mont-Liban, Lebanon.

A 60-year-old woman was investigated for abdominal pain and increasing asthenia. Abdominal CT revealed a 25 mm hypodense cystic lesion in the tail of the pancreas. MRI showed a multiloculated cystic lesion, T1-hypointense and T2-hyperintense lesion, without wall enhancement. Read More

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October 2020

Mixed-type intraductal papillary mucinous neoplasm: Tailored surgical planning - case report.

Int J Surg Case Rep 2020 24;76:111-115. Epub 2020 Sep 24.

Post Graduate Program in Health of Sciences, São Francisco University Medical School (USF), Bragança Paulista-SP, Brazil; Department of Surgery, University of Campinas, Campinas, SP, Brazil. Electronic address:

Introduction: With the greater availability of imaging exams, the diagnosis of intraductal papillary mucinous neoplasms (IPMNs) has increased recently. However, there are still questions about adequate management approaches for this disease, especially regarding the best therapeutic strategy. The objective is to describe the case of a patient with mixed-type (MT) IPMN successfully treated by a tailored surgical plan that adopted duodenopancreatectomy and imaging to monitor the remaining lesions of the tail and body of the pancreas. Read More

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September 2020

Non-Neoplastic and Neoplastic Cysts of the Pancreas.

Monogr Clin Cytol 2020 28;26:53-73. Epub 2020 Sep 28.

Office of Chief Medical Examiner, New York, New York, USA.

Inflammatory, developmental, and neoplastic lesions may all present as cystic masses on imaging. Pseudocyst is the most common of these and presents in association with a history of pancreatitis. Pancreatic cystic neoplasms are uncommon compared to solid neoplasms. Read More

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September 2020

Intraductal papillary mucinous neoplasm complicated with intraductal bleeding in a young woman mimicked a cystic solid pseudo-papillary tumor: a case report.

BMC Gastroenterol 2020 Sep 16;20(1):304. Epub 2020 Sep 16.

Department of Radiology, Fujian Provincial Hospital, Provincial clinic medical college of Fujian Medical University, NO.134, Eastern Road, Gulou District, Fuzhou, China.

Background: There are only 6 cases of intraductal papillary mucinous neoplasm (IPMN) complicated with intraductal hemorrhage have been reported in English literatures. All these 6 cases of IPMN occurred in the old people. The present rare case of IPMN complicated with intraductal hemorrhage occurred in a young woman, and mimicked a cystic solid pseudo-papillary neoplasm (SPN) on preoperative imaging findings. Read More

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September 2020

Mucinous cystic adenoma with inflammatory cell infiltration around the splenic artery mimicking pancreatic cancer: a case report.

Clin J Gastroenterol 2020 Dec 9;13(6):1360-1366. Epub 2020 Sep 9.

Department of Gastroenterology and Hepatology, Mie University Hospital, 2-174 Edobashi, Tsu, Mie, 514-8507, Japan.

A 45-year-old woman presented with upper abdominal and back pain. A cystic lesion in the pancreas and inflammation around the splenic artery were detected by computed tomography. Although imaging studies were difficult to exclude malignancy, pathological and cytological findings of a fine-needle aspiration showed no signs of malignancy. Read More

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December 2020

Intraductal Pancreatic Mucinous Neoplasms: A Tumor-Biology Based Approach for Risk Stratification.

Int J Mol Sci 2020 Sep 2;21(17). Epub 2020 Sep 2.

Department of Medical Oncology, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, 00168 Rome, Italy.

Pancreatic ductal adenocarcinoma is one of the most lethal human cancers. Its precursor lesions include pancreatic intra-epithelial neoplasia, mucinous cystic neoplasm, and intraductal papillary mucinous neoplasm (IPMN). IPMNs usually present as an incidental finding at imaging in 2. Read More

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September 2020

Pearls and pitfalls of imaging features of pancreatic cystic lesions: a case-based approach with imaging-pathologic correlation.

Jpn J Radiol 2021 Feb 25;39(2):118-142. Epub 2020 Aug 25.

Department of Radiology, Kanazawa University Graduate School of Medical Sciences, Kanazawa, Japan.

A variety of neoplastic and non-neoplastic lesions of the pancreas can present with a predominantly cystic architecture. These lesions are increasingly being detected as incidental findings on routine cross-sectional imaging following technological advances in these techniques and their widespread use. The different histopathological behaviors show various common and uncommon imaging findings, and some cases show similar appearance in spite of different histopathology. Read More

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February 2021

Validation of the clinical utility of 4 guidelines in the initial triage of mucinous cystic lesions of the pancreas based on cross-sectional imaging: Experience with 188 surgically-treated patients.

Eur J Surg Oncol 2020 11 25;46(11):2114-2121. Epub 2020 Jul 25.

Department of Hepatopancreatobiliary and Transplant Surgery, Singapore General Hospital, Academia Level 5, 20 College Road, Singapore, 169856, Singapore; Duke NUS Medical School, 8 College Road, Singapore, 169857, Singapore. Electronic address:

Introduction: Over the years, several guidelines have been introduced to guide management of mucinous pancreatic cystic neoplasms (mPCN). In this study, we aimed to evaluate and compare the clinically utility of the Sendai-06, Fukuoka-12, Fukuoka-17 and European-18 guidelines in predicting malignancy of mPCN.

Methods: One hundred and eighty-eight patients with mucinous cystic neoplasms (MCN) or intraductal papillary mucinous neoplasm (IPMN) who underwent surgery were retrospectively reviewed and classified under the 4 guidelines. Read More

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November 2020

Concurrent ductal adenocarcinoma, pseudocyst, and neuroendocrine tumor of the pancreas: A case report.

Medicine (Baltimore) 2020 Jul;99(30):e21354

Department of Radiology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Auhui, China.

Introduction: Pancreatic pseudocyst is one of the most common cystic lesions. It always occurs following pancreatitis and is rarely found in combination with pancreatic adenocarcinoma. The coexistence of exocrine and neuroendocrine tumors of the pancreas is also infrequent. Read More

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Mucinous cystic neoplasms of the pancreas associated with pregnancy: Two case reports.

Medicine (Baltimore) 2020 Jul;99(31):e21471

Department of Surgery, UT Southwestern Medical Center, Dallas, TX.

Rationale: Although rare, pancreatic neoplasms can occur during pregnancy, both in benign and malignant forms. Mucinous cystic neoplasms (MCNs) of the pancreas, a type of these neoplasms, are precursor lesions to invasive pancreatic cancer. The presence of the ovarian-type stroma is a defining feature. Read More

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EGFR Mutated Lung Adenocarcinoma Metastasis to the Pancreas Mimicking Primary Pancreatic Ductal Carcinoma.

Anticancer Res 2020 Aug;40(8):4401-4404

Department of Pathology and Laboratory Medicine, Kaiser Permanente Sacramento Medical Center, Sacramento, CA, U.S.A.

Background: The occurrence of lung adenocarcinoma metastasizing to the pancreas is overall rare and can histologically imitate primary pancreatic ductal carcinoma (PDAC).

Case Report: This is a case report of a 70-year-old female with a history of surgically resected right lung adenocarcinoma presenting for routine follow up without symptoms. CT scans revealed a pancreatic cystic mass with ductal dilatation that was sampled via endoscopic ultrasound-guided fine needle aspiration (EUS-FNA) and thought to be a primary pancreatic mucinous neoplasm with high grade dysplasia suspicious for carcinoma based on smear cytology. Read More

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Discrimination of serous cystadenoma from mucinous cystic neoplasm and branch duct intraductal papillary mucinous neoplasm in the pancreas with CT.

Abdom Radiol (NY) 2020 09 23;45(9):2772-2778. Epub 2020 Jul 23.

Department of Radiology, Xinqiao Hospital, Third Military Medical University, Chongqing, 400037, China.

Purpose: The imaging features of serous cystadenomas (SCAs) overlap with those of mucinous cystic neoplasms (MCNs) and branch duct intraductal papillary mucinous neoplasms (BD-IPMNs), and an accurate preoperative diagnosis is important for clinical treatment due to their different biological behaviors. The aim of this study was to provide a computed tomographic (CT) feature for the diagnosis of SCAs and estimate whether the "circumvascular sign" can contribute to the discrimination of SCAs from MCNs and BD-IPMNs.

Methods: From August 2011 through December 2019, a total of 71 patients (30 patients with 30 SCAs, 21 patients with 21 MCNs and 20 patients with 22 BP-IPMNs) were enrolled in this study. Read More

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September 2020

[Quality of indications in cystic lesions of the pancreas].

Chirurg 2020 Sep;91(9):736-742

Klinik für Allgemein, Viszeral- und Transplantationschirurgie, Klinikum der Universität München, Standort Großhadern, Marchioninistr. 15, 81377, München, Deutschland.

Cystic tumors of the pancreas (PCN) have increasingly gained importance in the clinical routine as they are frequently diagnosed as an incidental finding due to the continuous improvement in cross-sectional imaging. A differentiation is made between non-neoplastic and neoplastic cysts, whereby the latter has a tendency to malignant transformation to a varying extent. Therefore, they can be considered as precursor lesions of pancreatic cancer (PDAC). Read More

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September 2020

Multimodal radiomics and cyst fluid inflammatory markers model to predict preoperative risk in intraductal papillary mucinous neoplasms.

J Med Imaging (Bellingham) 2020 May 25;7(3):031507. Epub 2020 Jun 25.

Queen's University, School of Computing, Kingston, Ontario, Canada.

Our paper contributes to the burgeoning field of surgical data science. Specifically, multimodal integration of relevant patient data is used to determine who should undergo a complex pancreatic resection. Intraductal papillary mucinous neoplasms (IPMNs) represent cystic precursor lesions of pancreatic cancer with varying risk for malignancy. Read More

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[Clinical diagnosis and treatment characteristics of pancreatic cystic neoplasms in pediatric patients: a report of 13 cases].

Zhonghua Wai Ke Za Zhi 2020 Jul;58(7):525-529

Department of General Surgery, Wuhan Children's Hospital, Tongji Medical College, Huazhong University of Science & Technology, Wuhan 430014, China.

To investigate the clinical characteristics of pancreatic cystic neoplasms in pediatric patients. The clinical data of 13 patients with pancreatic cystic neoplasm at Wuhan Children's Hospital from July 2007 to November 2019 were collected.There were 5 males and 8 females, with a mean age of 133 months(range: 9 to 170 months). Read More

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Giant pancreatic mucinous cystadenoma masquerading as renal hydatid disease.

Urol Ann 2020 Apr-Jun;12(2):184-186. Epub 2020 Apr 14.

Department of Urology, MIOT International, Chennai, Tamil Nadu, India.

Mucinous cystic neoplasms of the pancreas are the most common pancreatic cystic neoplasms. A 54-year-old female presented with an abdominal mass and was diagnosed to have a multilocular hydatid cyst from the left kidney by imaging. During surgery, a large thick-walled cyst with multiple loculi was seen arising from the upper pole of the left kidney and adherent to the distal pancreas and splenic vessels. Read More

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Nondiagnostic fine-needle aspirates of the pancreas: A root cause analysis.

Cancer Cytopathol 2020 10 11;128(10):704-714. Epub 2020 Jun 11.

Department of Pathology, Case Western Reserve University, University Hospitals Cleveland Medical Center, Cleveland, Ohio.

Background: Fine-needle aspiration (FNA) of the pancreas is considered the primary and least invasive diagnostic method in the evaluation of pancreatic lesions. A nondiagnostic sample may trigger repeat FNA or a more invasive diagnostic procedure. The goal of this study was to identify the root causes of nondiagnostic samples. Read More

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October 2020