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Int J Cardiovasc Imaging 2019 Apr 10. Epub 2019 Apr 10.

Department of Cardiovascular Diseases, University of Siena, Viale Bracci 1, Siena, Italy.

For patients with asymptomatic mitral regurgitation (MR), the criteria identifying the groups at higher-risk and their clinical outcome are still uncertain. Therefore, in these patients, optimal time of surgery remains controversial. The purpose of this study was to compare left atrial (LA) strain to other echocardiographic left ventricular (LV) and LA parameters for the prediction of cardiovascular outcomes in patients with moderate asymptomatic MR. Read More

Zhong Nan Da Xue Xue Bao Yi Xue Ban 2019 Mar;44(3):290-296

Department of Radiology, Third Xiangya Hospital, Central South University, Changsha 410013, China.

Objective: To assess the performance of radiomics model based on cardiac magnetic resonance imaging (CMR) cine sequence for assessing the severity of mitral regurgitation.
 Methods: A total of 80 patients who underwent CMR and echocardiography examination were retrospectively enrolled, including 67 patients with no or slight mitral regurgitation and 13 patients with moderate or severe mitral regurgitation. The relative difference in average filtered gradient (RDAFG) of CMR cine sequence were generated, which were combined with minimum output sum of squared error tracker (MOSSE) to extract 25 radiomics features. Read More

Am J Cardiol 2019 Mar 18. Epub 2019 Mar 18.

Department of Pediatrics, Division of Pediatric Cardiology, Adnan Menderes University Hospital, Aydın, Turkey. Electronic address:

Early impairment of left ventricular (LV) function has been reported in some inherited connective tissue diseases such as Marfan syndrome or rheumatic heart disease in pediatric patients. However, there is no study about cardiac strain in pediatric patients with primary mitral valve prolapse (MVP). The aim of this study was to evaluate the LV functions in pediatric patients with primary MVP, mild or moderate mitral regurgitation (MR), and normal LV ejection fraction. Read More

Int J Cardiol 2019 Mar 27. Epub 2019 Mar 27.

Heart Center, Segeberger Kliniken, Bad Segeberg, Germany.

Background: The management of patients with mitral regurgitation (MR) undergoing transcatheter aortic valve replacement (TAVR) is challenging. We sought to investigate the evolution and long-term prognostic impact of residual post-TAVR MR.

Methods: The severity of MR was assessed at baseline and at 30 days and six months post-TAVR. Read More

JACC Cardiovasc Imaging 2019 Apr;12(4):652-664

Department of Cardiac, Thoracic, and Vascular Sciences, University of Padua School of Medicine, Padua, Italy; IRCCS, Instituto Auxologico Italiano, S. Luca Hospital, University of Milano-Biococca, Milan, Italy.

Current guidelines recommend transthoracic echocardiography to assess patients with functional tricuspid regurgitation (FTR) because it provides information regarding the presence of structural abnormalities of the tricuspid valve (TV), allows measurement of tricuspid annulus diameter, and evaluates severity of FTR by integrating data obtained from 2D and Doppler echocardiography. Critical components of the noninvasive evaluation include information regarding TV anatomy, tricuspid regurgitation severity, right ventricular size and systolic function, and associated findings such as estimated pulmonary artery pressure. However, most of the parameters included in the current recommendations to assess FTR are derived from the experience and knowledge developed about the mitral valve and have been transferred from the left to the right side of the heart without accounting for differences in anatomy of the tricuspid and mitral apparatus or for differences in hemodynamic environment in which the TV operates compared to its left counterpart. Read More

BMC Cardiovasc Disord 2019 Apr 3;19(1):80. Epub 2019 Apr 3.

Departamento de Fisiología, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Sierra Mojada 950, Col. Independencia, Guadalajara, Jalisco, México.

Background: There are three major mechanical complications after acute myocardial infarction: left ventricular free-wall rupture, ventricular septum rupture and acute mitral valve regurgitation. The left ventricular free-wall rupture is a serious and often lethal complication following an ST elevation myocardial infarction. However, very rarely this rupture can be contained by the pericardium, forming a pseudoaneurysm. Read More

Mayo Clin Proc 2019 Mar 29. Epub 2019 Mar 29.

Clinician-Investigator Training Program, Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN. Electronic address:

A 51-year-old man with a long-standing history of bileaflet mitral valve prolapse accompanied by mitral annular disjunction and mild mitral regurgitation presented for evaluation of increasingly frequent palpitations. Ambulatory Holter monitoring, cardiac magnetic resonance imaging, serial transthoracic echocardiography, and diagnostic electrophysiology studies were consistent with a diagnosis of arrhythmogenic bileaflet mitral valve prolapse syndrome. Because of the presence of a similar phenotype in the proband's mother, brother, and maternal aunt, research-based whole exome sequencing was pursued and a novel truncating variant (p. Read More

Kyobu Geka 2019 Mar;72(3):184-189

Department of Cardiovascular Surgery, Kagoshima University Hospital, Kagoshima, Japan.

Functional mitral regurgitation( FMR) is a risk factor that increases the mortality rate and incidence of heart failure. Surgical intervention is important. Mitral valve (MV) reconstruction can preserve the valvular apparatus;no anticoagulation therapy is required, left ventricular function is preserved. Read More

Kyobu Geka 2019 Mar;72(3):178-181

Department of Cardiovascular Surgery, Ogaki Municipal Hospital, Ogaki, Japan.

An 80-year-old male was admitted to our hospital because of subacute myocardial infarction with moderate mitral regurgitation. Though he recovered well and went home within 2 weeks, the transthoracic echocardiography revealed rapid growing aneurysmal changes at the left ventricular posterior wall. We made diagnose of a pseudoaneurysm by the multi detector-row computed tomography, and planed a surgical treatment. Read More

Eur Heart J Cardiovasc Imaging 2019 04;20(4):406

J Cardiovasc Magn Reson 2019 Mar 18;21(1):20. Epub 2019 Mar 18.

Department of Pediatric Cardiology, University Medical Center Utrecht / Wilhelmina Children's Hospital, Utrecht, The Netherlands.

Background: Aortic regurgitation (AR) and subclinical left ventricular (LV) dysfunction expressed by myocardial deformation imaging are common in patients with transposition of the great arteries after the arterial switch operation (ASO). Echocardiographic evaluation is often hampered by reduced acoustic window settings. Cardiovascular magnetic resonance (CMR) imaging provides a robust alternative as it allows for comprehensive assessment of degree of AR and LV function. Read More

JACC Cardiovasc Imaging 2019 Mar 13. Epub 2019 Mar 13.

Cardiology University Department, Heart Failure Unit, IRCCS Policlinico San Donato, San Donato Milanese, Milan, Italy; Department for Biomedical Sciences for Health, University of Milano, Milan, Italy. Electronic address:

Objectives: The aim of this study was to identify the pattern of exercise left atrial (LA) dynamics, its gas exchange correlates, and prognosis in mitral regurgitation (MR) of primary and secondary origin.

Background: The adaptive response and clinical significance of LA function during exercise in MR is undefined.

Methods: A total of 196 patients with MR (81 with primary MR, 115 with secondary MR) and 54 control subjects underwent exercise stress echocardiography and cardiopulmonary exercise testing with LA function assessment. Read More

Turk Kardiyol Dern Ars 2019 03;47(2):88-94

Department of Cardiology, Health Science University, Antalya Training and Research Hospital, Antalya, Turkey.

Objective: Cardiovascular disease is the leading cause of mortality in patients undergoing dialysis. Most of the available studies focus on left ventricular (LV) function in peritoneal dialysis (PD) patients; data about the effect of PD on right ventricular (RV) function are scarce. The aim of this study was to evaluate echocardiographic parameters of the RV in patients with end-stage renal disease (ESRD) undergoing PD. Read More

Eur Heart J Cardiovasc Imaging 2019 Mar 12. Epub 2019 Mar 12.

Department of Cardiology, AORN Ospedali dei Colli-Monaldi, Naples, Italy.

Aims: Functional mitral regurgitation (FMR) is a well-known pathophysiological factor in heart failure (HF) patients, and left atrial function (LAF) is a novel determinant of clinical status and outcome in this setting. However, little is known about the pathophysiological role of FMR on LAF in HFrEF patients. Aim of this study is to explore the possible interplay between the severity of FMR and LAF in heart failure with reduce ejection fraction (HFrEF) patients and their possible consequences. Read More

Lancet 2019 03;393(10175):1056-1070

Department of Cardiology, Leiden University Medical Center, Leiden, Netherlands.

In heart failure, extensive evaluation with modern non-invasive imaging modalities is needed to assess causes, pathophysiology, and haemodynamics, to determine prognosis and consider therapeutic options. This systematic evaluation includes a stepwise assessment of left ventricular size and function, the presence and severity of coronary artery disease, mitral regurgitation, pulmonary hypertension, right ventricular dilation and dysfunction, and tricuspid regurgitation. Based on this imaging-derived information, the need for specific therapies besides optimised medical therapy can be determined. Read More

J Am Coll Cardiol 2019 Mar;73(9):1078-1088

CHU Lille, Université de Lille, Inserm U1011 - EGID, Institut Pasteur de Lille, Lille, France; CHU Lille, Hematology and Transfusion, Lille, France. Electronic address:

For decades, numerous observations have shown an intimate relationship between von Willebrand factor (VWF) multimer profile and heart valve diseases (HVD). The current knowledge of the unique biophysical properties of VWF helps us to understand the longstanding observations concerning the bleeding complications in patients with severe HVD. Not only does the analysis of the VWF multimer profile provide an excellent evaluation of HVD severity, it is also a strong predictor of clinical events. Read More

Echocardiography 2019 04 4;36(4):722-731. Epub 2019 Mar 4.

Institut Universitaire de Cardiologie et de Pneumologie de Québec - Université Laval, Québec City, Québec, Canada.

Background: Significant mitral regurgitation (MR) is associated with poorer outcomes in patients undergoing transcatheter aortic valve replacement (TAVR). Factors associated with MR improvement have not been studied thoroughly.

Methods: Retrospective analysis of consecutive patients treated with TAVR with more than mild MR at baseline. Read More

Heart Fail Clin 2019 Apr 10;15(2):219-227. Epub 2019 Feb 10.

King's Health Partners, King's College Hospital NHS Foundation Trust, King's College Hospital, Denmark Hill, London SE5 9RS, UK.

Secondary regurgitation caused by the remodeling and dysfunction of the left or right heart chamber may complicate heart failure, worsening both symptoms and prognosis. Outcome studies have shown that patients' prognosis worsened as the severity of secondary regurgitation increases. Imaging and more specifically echocardiography plays a central role for diagnosis and serial assessment of secondary regurgitation as well as for timing the intervention and guiding the procedure. Read More

JACC Cardiovasc Interv 2019 Mar 27;12(6):592-594. Epub 2019 Feb 27.

Division of Cardiology, Department of Internal Medicine, Baylor University Medical Center and Baylor Scott and White Heart Hospital in Dallas, Dallas, Texas. Electronic address:

Heart 2019 May 1;105(9):671-677. Epub 2019 Mar 1.

Department of Clinical Laboratory, Noninvasive Cardiovascular Imaging, Miyazaki Medical Association Hospital Cardiovascular Center, Miyazaki, 880-0834, Japan.

The diagnosis of acute mitral regurgitation (MR) is often missed or delayed because the clinical presentation is substantially different from that in patients with chronic MR. Management of acute MR depends on the specific aetiology of valve dysfunction and there is a lack of consensus on the optimal therapeutic approach in many patients. In particular, management of secondary MR due to acute ischaemia is challenging because of unique mechanisms of valve incompetence compared with chronic ischaemic MR. Read More

J Am Heart Assoc 2019 Mar;8(5):e010974

1 Department of Medicine Weill Cornell Medical College New York NY.

Background Mitral regurgitation ( MR ) has the potential to impede exercise capacity; it is uncertain whether this is because of regurgitation itself or the underlying cause of valvular insufficiency. Methods and Results The population comprised 3267 patients who underwent exercise treadmill myocardial perfusion imaging and transthoracic echocardiography within 6±8 days. MR was present in 28%, including 176 patients (5%) with moderate or greater MR . Read More

Int Heart J 2019 Mar 22;60(2):336-344. Epub 2019 Feb 22.

Shanghai Institute of Cardiovascular Disease.

Data involving combined mitral and aortic valve procedure via the right mini-thoracotomy approach are very limited. This single-center propensity-matching study aimed to evaluate early clinical outcomes of patients who underwent combined mitral and aortic valve procedure via right mini-thoracotomy versus full median sternotomy.From January 2013 to December 2016, 926 eligible patients in our center were identified for this study. Read More

J Am Soc Echocardiogr 2019 Apr 20;32(4):431-475. Epub 2019 Feb 20.

West Virginia University Heart & Vascular Institute, Morgantown, West Virginia.

J Vet Cardiol 2019 Feb 25;21:93-97. Epub 2019 Jan 25.

Department of Clinical Sciences, Colorado State University, 300 W Drake Rd., Fort Collins, CO 80523, USA.

A 10-week-old male intact mixed breed dog presented for evaluation of suspected right-sided congestive heart failure. Echocardiographic imaging revealed a perforate cor triatriatum dexter (CTD), along with pulmonary valve stenosis and tricuspid and mitral valve dysplasia. In typical CTD cases, there is unidirectional blood flow across the dividing membrane, from the caudal into the cranial right atrial chambers. Read More

J Vet Cardiol 2019 Feb 11;21:18-27. Epub 2018 Dec 11.

Department of Veterinary Pathology, College of Veterinary Medicine, Iowa State University, 1809 S. Riverside Drive, Ames, IA 50011, USA.

Introduction: To determine whether dogs with atrial fibrillation (AF) are more likely to develop right-sided manifestations of congestive heart failure (R-CHF) than dogs without AF.

Animals: Two hundred twenty dogs diagnosed with congestive heart failure (CHF) secondary to degenerative mitral valve disease (DMVD, n = 155) or dilated cardiomyopathy (DCM, n = 65) at a referral institution.

Methods: Medical records were reviewed to extract relevant clinical and echocardiographic data. Read More

Catheter Cardiovasc Interv 2019 Feb 21. Epub 2019 Feb 21.

Greenberg Cardiology Division, Weill Cornell Medicine, New York, New York.

Objectives: To assess impact of left ventricular (LV) chamber remodeling on MitraClip (MClp) response.

Background: MitraClip is the sole percutaneous therapy approved for mitral regurgitation (MR) but response varies. LV dilation affects mitral coaptation; determinants of MClp response are uncertain. Read More

Heart 2019 Feb 16. Epub 2019 Feb 16.

Department of Cardiology, Hospital General Universitario Gregorio Maranon, Madrid, Spain.

Objective: To obtain reference values of aortic valve area (AVA) in a large population and to infer the risk of overestimating aortic stenosis (AS) when focusing on flow-corrected indices of severity.

Methods: We prospectively measured indices of AS in all consecutive echocardiograms performed in a large referral cardiac imaging laboratory for 1 year. We specifically analysed the distribution of AVA, indexed AVA and velocity ratio (Vratio) in patients with and without AS, the latter defined as the coexistence of valvular outflow obstruction (Vmax ≥2. Read More

Cardiol J 2019 Feb 14. Epub 2019 Feb 14.

Abbott Health Economics & Reimbursement.

There is a great need for innovative technologies that will improve the health and quality of life (QoL) of Polish patients with cardiac problems. It is important that the safety and effectiveness of the technology are confirmed by scientific evidence on which guidelines and clinical recommendations are based. Scientific evidence for medical devices is also increasingly important for decision-making in finance approval from public funds. Read More

J Cardiovasc Echogr 2018 Oct-Dec;28(4):207-217

Luigi Vanvitelli University, Monaldi Hospital, AORN Ospedali Dei Colli, Naples, Italy.

Mitral valve prolapse is generally a benign condition characterized by fibromyxomatous changes of the mitral leaflet with displacement into the left atrium and late-systolic regurgitation. Although it is an old clinical entity, it still arouses perplexity in diagnosis and clinical management. Complications, such as mitral regurgitation (MR), atrial fibrillation, congestive heart failure, endocarditis, ventricular arrhythmias, and sudden cardiac death (SCD), have been reported. Read More

J Thorac Dis 2018 Dec;10(12):6969-6986

Department of Cardiology, Hospital Universitario de Canarias, Tenerife, Spain.

Ischemic mitral regurgitation (IMR) is a frequent complication after acute myocardial infarction (AMI) associated with a worse prognosis. The pathophysiological mechanisms of IMR are not fully understood, but it is known to be a complex process in which ventricular remodelling is the main causal factor. The various imaging techniques in cardiology and echocardiography fundamentally have contributed significantly to clarify the mechanisms that cause and progressively aggravate IMR. Read More

BMC Infect Dis 2019 Jan 31;19(1):102. Epub 2019 Jan 31.

Okinawa Prefectural Nanbu Medical Center & Children's Medical Center, Department of General Pediatrics, Okinawa, Japan.

Background: Infective endocarditis (IE) is defined as endocarditis caused by microorganisms (bacteria or fungi) involving either the heart or great vessels. The clinical course of IE can be complicated by cardiac dysfunction and bacterial embolization to virtually any organ. Staphylococcus aureus and viridans group streptococci are the most common causative organisms, whereas group A Streptococcus (GAS) is less common. Read More

Circ Cardiovasc Imaging 2019 Feb;12(2):e007928

The Heart Institute, Cincinnati Children's Hospital Medical Center, OH (A.Z.B.).

Background: The 2012 World Heart Federation Criteria are the current gold standard for the diagnosis of latent rheumatic heart disease (RHD). Because data and experience using these criteria have grown, there is opportunity to simplify and develop outcome prediction tools. We aimed to develop a simple echocardiographic score applicable for RHD screening with potential to predict disease progression. Read More

J Cardiovasc Imaging 2019 Jan;27(1):50-63

Department of Internal Medicine, Seoul National University College of Medicine, Seoul National University Hospital, Seoul, Korea.

Background: We compared the gene expression profiles in the hypertrophied myocardium of rats subjected to pressure overload (PO) and volume overload (VO) using DNA chip technology, and compared the effects on exercise capacity with a treadmill test.

Methods: Constriction of the abdominal aorta or mitral regurgitation induced by a hole in the mitral leaflet were used to induce PO (n = 19), VO (n = 16) or PO + VO (n = 20) in rats. Serial echocardiographic studies and exercise were performed at 2-week intervals, and invasive hemodynamic examination by a pressure-volume catheter system was performed 12 weeks after the procedure. Read More

Medicine (Baltimore) 2019 Jan;98(4):e14090

Department of Cardiovascular Center, the Fourth Affiliated Hospital of Xinjiang Medical University, Urmuqi, China.

The objective of the study was to determine the geometric changes in mitral annular and/or leaflets spatial conformation in patients with atrial fibrillation (AF) complicated with severe atrial mitral regurgitation (AMR) by using real-time 3-dimensional transesophageal echocardiography, aiming to explore whether this condition could be improved through self-modulation of mitral annulus and/or leaflets after the restoration of sinus rhythm.Fifty-five patients who were diagnosed with AMR and subject to 1-year follow-up were recruited in this clinical trial. All patients successfully received AF ablation. Read More

JACC Cardiovasc Imaging 2019 Jan 9. Epub 2019 Jan 9.

Cardiac Ultrasound Laboratory, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.

Braz J Cardiovasc Surg 2018 Nov-Dec;33(6):634-637

Universidade Estadual de Ponta Grossa (UEPG), Ponta Grossa, PR, Brazil.

This paper presents a case study of a 30-year-old male patient with dyspnea on exertion had echocardiographic diagnosis of aortic subvalvar stenosis. Discrete mitral regurgitation and aortic valve dysplasia with mild to moderate insufficiency and hypertrophic cardiomyopathy were also noted. During surgery, a rare condition was identified: presence of papillary muscle anomaly associated with the subaortic membrane as a cause of obstruction of the left ventricular outflow tract. Read More

Braz J Cardiovasc Surg 2018 Nov-Dec;33(6):573-578

Department of Cardiovascular Surgery, Okan University, Medicine Faculty Hospital, Istanbul, Turkey.

Introduction: The aim of this study is to investigate the change in the dimension of sinus of Valsalva in patients who underwent supracoronary ascending aorta replacement with aortic valve replacement.

Methods: A total of 81 patients who underwent supracoronary ascending aorta replacement with aortic valve replacement were included. Ten of 81 patients died during the follow-up. Read More

J Matern Fetal Neonatal Med 2019 Jan 17:1-12. Epub 2019 Jan 17.

a Hospital General Universitario Gregorio Marañón , Madrid , Spain.

Early onset Marfan syndrome is the most severe form of Marfan syndrome diagnosed during perinatal period. Early onset Marfan syndrome is associated with high mortality rates, usually within the first 2 years of life. First, we present a case of prenatally diagnosed early onset Marfan syndrome in a dichorionic diamniotic twin pregnancy, where suspicion was raised at 35 weeks of gestation. Read More

A A Pract 2019 Jan 3. Epub 2019 Jan 3.

Division of Cardiac Surgery, Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts.

Intraoperative evaluation of mitral regurgitation is a complex undertaking. Bileaflet prolapse/flail can result in divergent mitral regurgitation jets with a characteristic "crossed swords sign" appearance. We present a case of divergent mitral regurgitation jets that were detected intraoperatively and evaluated using 3-dimensional imaging. Read More

Int Heart J 2019 Mar 10;60(2):474-476. Epub 2019 Jan 10.

Department of Internal Medicine, Tianjin NanKai Hospital.

Simultaneous left and right-sided native valve infective endocarditis (IE) is rare. Staphylococcus aureus was the predominant organism for bilateral IE. Shunt diseases are common risk factors of both-sided IE. Read More

J Cardiothorac Surg 2019 Jan 9;14(1). Epub 2019 Jan 9.

Department of Thoracic and Cardiovascular Surgery, Yokohama Sakae Kyosai Hospital, 132 Katsura-cho, Sakae-ku, Yokohama, Kanagawa, 247-8581, Japan.

Background: Atrioventricular groove hematomas during mitral valve surgery range from simple hematomas to complex atrioventricular disruptions that cause frank rupture with massive bleeding and subsequent mortality. A small or moderate-sized hematoma is reported to be present in the left atrioventricular groove in 10 to 30% of all patients immediately after mitral valve replacement. Despite the fact that atrioventricular groove hematomas are inherently unstable and unpredictable, conservative strategies are recommended due to the high mortality associated with additional surgical repair. Read More

J Card Surg 2019 Jan 9;34(1):14-19. Epub 2019 Jan 9.

Department of Surgery, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

Background: We sought to analyze clinical features and surgical results of 10 cases of cardiac myxomas in Carney complex (CNC).

Methods: Between January 2003 and December 2013, 10 patients with cardiac myxomas in CNC underwent surgical resection. Associated cardiac lesions included moderate and severe mitral regurgitation in two cases, and moderate tricuspid regurgitation in one case. Read More

Eur Heart J Cardiovasc Imaging 2019 04;20(4):385-386

University of Liège, Division of Cardiology, University Hospital Sart Tilman, Liège, Belgium.

Heart Surg Forum 2018 11 7;21(6):E443-E447. Epub 2018 Nov 7.

Department of Cardiac Surgery, Beijing Anzhen Hospital, Capital Medical University, Beijing 100029, China.

Background: We sought to analyze the pathological characteristics of hypertrophic obstructive cardiomyopathy (HOCM) with concomitant mitral valve abnormalities and to discuss the surgical treatment strategies.

Methods: The clinical data of 26 HOCM patients treated from January 2014 to March 2016 were retrospectively analyzed. There were 19 males and 7 females with a mean age of 47 ± 16 years (range, 10-70 years). Read More

Interact Cardiovasc Thorac Surg 2019 Jan 2. Epub 2019 Jan 2.

Department of Cardiothoracic Surgery, Oslo University, Oslo, Norway.

Objectives: Transcatheter mitral valve replacement has recently been introduced as an alternative treatment option for severe mitral regurgitation. We present our single-centre first experience with screening and implantation outcomes.

Methods: Twenty-five patients with mitral regurgitation grades 3 and 4 were screened based on study inclusion/exclusion criteria, echocardiography and computed tomography imaging. Read More

Ann Cardiothorac Surg 2018 Nov;7(6):780-786

Department of Cardiac Surgery, University of Michigan Health System, Ann Arbor, MI, USA.

The IRIS mitral annuloplasty ring is a transcatheter, transfemoral and transseptal-delivered complete, semi-rigid annuloplasty ring. The IRIS system mimics surgical annuloplasty by reducing the mitral septal-lateral dimension and improving leaflet coaptation. We report the early experience with the IRIS system in seven patients. Read More

Ann Cardiothorac Surg 2018 Nov;7(6):731-740

Heart Valve Clinic, University Hospital of Zürich, University of Zürich, Zürich, Switzerland.

The field of mitral valve disease diagnosis and management is rapidly evolving. New understanding of pathophysiology and improvements in the adoption of sophisticated multimodality imaging modalities have led to early diagnosis and to more complex treatment. The most common cause of mitral regurgitation (MR) in the western world is in the primary alteration of the valve, which leads to degenerative leaflet prolapse due to chordal elongation or rupture and annular dilatation. Read More

Ann Cardiothorac Surg 2018 Nov;7(6):716-723

CORE Research Group, Macquarie University, Sydney, Australia.

Background: Valvular heart disease is an important cause of morbidity and mortality throughout the world; in industrialized nations, mitral regurgitation (MR) is the most common valvular lesion. Untreated, severe MR has a poor prognosis, with a 5-year mortality rate of up to 50%. Surgical repair of symptomatic, severe primary MR has been demonstrated to improve survival. Read More

Comput Methods Biomech Biomed Engin 2018 Dec 31:1-16. Epub 2018 Dec 31.

c Department of Mechanical Engineering , University of Birmingham , Birmingham , UK.

The aim of this study is to simulate the Mitral Regurgitation (MR) disease progression from mild to severe intensity. A Fluid Structure Interaction (FSI) model was developed to extract the hemodynamic parameters of blood flow in mitral regurgitation (MR) during systole. A two-dimensional (2D) geometry of the mitral valve was built based on the data resulting from Magnetic Resonance Imaging (MRI) dimensional measurements. Read More

Perfusion 2018 Dec 31:267659118820776. Epub 2018 Dec 31.

1 Department of Cardiology, Medical Academy, Lithuanian University of Health Sciences, Kaunas, Lithuania.

Objectives:: To evaluate the impact of concomitant tricuspid valve (TV) repair on the right ventricular (RV) function postoperatively and within the 6 months following degenerative mitral valve (MV) repair.

Methods:: The prospective study included 37 patients (mean age 57.32 ± 2. Read More