J Pediatr Hematol Oncol 2021 Mar 3. Epub 2021 Mar 3.
Hematopoietic Stem Cell Transplantation Unit, Department of Haemato-Oncology Child Neuropsychiatry Unit Neuroradiology Unit, IRCSS Istituto Giannina Gaslini, Genoa, Italy Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (DINOGMI), University of Genoa, Genoa Department of Pediatrics, Pediatric Oncology and Haematology Unit "Lalla Seràgnoli" Child Neurology and Psychiatry Unit, St. Orsola-Malpighi Hospital, University of Bologna Neuroradiology Unit, IRCCS Istituto delle Scienze Neurologiche di Bologna, Bologna Department of Neuroscience, University of Turin, Turin, Italy.
Objectives: Drug resistant epilepsy has rarely been reported following posterior reversible encephalopathy syndrome (PRES), with few cases of mesial temporal sclerosis (MTS). The aim of this study was to report clinical and neuroimaging features of MTS subsequent to PRES in haemato-oncological/stem cell transplanted children.
Materials And Methods: Among 70 children treated in 2 pediatric haemato-oncological Italian centers between 1994 and 2018 and presenting an episode of PRES, we retrospectively identified and analyzed a subgroup of patients who developed epilepsy and MTS. Read More