27 results match your criteria Imaging in Medicine [Journal]

  • Page 1 of 1

Recent developments in dynamic contrast-enhanced ultrasound imaging of tumor angiogenesis.

Imaging Med 2014 Feb;6(1):41-52

Department of Radiology, University of Alabama at Birmingham, Birmingham, AL, USA ; Biomedical Engineering, University of Alabama at Birmingham, Birmingham, AL, USA ; Electrical & Computer Engineering, University of Alabama at Birmingham, Birmingham, AL, USA ; Comprehensive Cancer Center, University of Alabama at Birmingham, Volker Hall G082, 1670 University Boulevard, Birmingham, AL 35294, USA.

Angiogenesis is a critical process for tumor growth and metastatic dissemination. There is tremendous interest in the development of noninvasive methods for imaging tumor angiogenesis, and ultrasound (US) is an emerging platform technology to address this challenge. The introduction of intravascular microbubble contrast agents not only allows real-time visualization of tumor perfusion during an US examination, but they can be functionalized with specific ligands to permit molecular US imaging of angiogenic biomarkers that are overexpressed on the tumor endothelium. Read More

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http://dx.doi.org/10.2217/iim.13.74DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4160124PMC
February 2014
3 Reads

Diffusion tensor MRI as a biomarker in axonal and myelin damage.

Imaging Med 2013 Oct;5(5):427-440

Department of Radiology, Washington University, School of Medicine, 510 South Kingshighway Boulevard, St Louis, MO 63110, USA ; Department of Neurological Surgery, Washington University School of Medicine, St Louis, MO, USA.

Diffusion tensor imaging has been used extensively as a research tool to understand the structural changes associated with white matter pathology. Using water diffusion as the basis to construct anatomic details, diffusion tensor imaging offers the potential to identify structural and functional adaptations before gross anatomical changes, such as lesions and tumors, become apparent on conventional MRI. Over the past 10 years, further parameters, such as axial and radial diffusivity, have been developed to characterize white matter changes specific to axons and myelin. Read More

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http://dx.doi.org/10.2217/iim.13.49DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4004089PMC
October 2013
1 Read

Effect of disease and recovery on functional anatomy in brain tumor patients: insights from functional MRI and diffusion tensor imaging.

Imaging Med 2013 Aug;5(4):333-346

Department of Neurosurgery, Brigham & Women's Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA ; Department of Radiology, Brigham & Women's Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA.

Patients with brain tumors provide a unique opportunity to understand functional brain plasticity. Using advanced imaging techniques, such as functional MRI and diffusion tensor imaging, we have gained tremendous knowledge of brain tumor behavior, transformation, infiltration and destruction of nearby structures. Using these advanced techniques as an adjunct with more proven techniques, such as direct cortical stimulation, intraoperative navigation and advanced microsurgical techniques, we now are able to better formulate safer resection trajectories, perform larger resections at reduced risk and better counsel patients and their families about possible complications. Read More

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http://dx.doi.org/10.2217/iim.13.40DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3959954PMC
August 2013
11 Reads

Quantitative analysis of structural neuroimaging of mesial temporal lobe epilepsy.

Imaging Med 2013 Jun;5(3)

Department of Neurology, Reed, Neurological Research Center, Suite, 2155, University of California, 710 Westwood Plaza, Los Angeles, CA 90095, USA.

Mesial temporal lobe epilepsy (MTLE) is the most common of the surgically remediable drug-resistant epilepsies. MRI is the primary diagnostic tool to detect anatomical abnormalities and, when combined with EEG, can more accurately identify an epileptogenic lesion, which is often hippocampal sclerosis in cases of MTLE. As structural imaging technology has advanced the surgical treatment of MTLE and other lesional epilepsies, so too have the analysis techniques that are used to measure different structural attributes of the brain. Read More

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http://dx.doi.org/10.2217/iim.13.28DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3847906PMC
June 2013
2 Reads

Harnessing advances in structural MRI to enhance research on Parkinson's disease.

Imaging Med 2013 Apr;5(2):91-94

Department of Neurology and the Center for Integrative Neuroscience, University of California, San Francisco, 675 Nelson Rising Lane, San Francisco, CA 94158 USA.

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http://dx.doi.org/10.2217/iim.13.8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3655710PMC
April 2013
2 Reads

Myocardial perfusion imaging with PET.

Imaging Med 2013 Feb;5(1):35-46

Departments of Imaging & Medicine, & Cedars-Sinai Heart Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA.

PET-myocardial perfusion imaging (MPI) allows accurate measurement of myocardial perfusion, absolute myocardial blood flow and function at stress and rest in a single study session performed in approximately 30 min. Various PET tracers are available for MPI, and rubidium-82 or nitrogen-13-ammonia is most commonly used. In addition, a new fluorine-18-based PET-MPI tracer is currently being evaluated. Read More

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http://dx.doi.org/10.2217/iim.13.1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3650901PMC
February 2013
6 Reads

FDG-PET/CT imaging biomarkers in head and neck squamous cell carcinoma.

Imaging Med 2012 Dec;4(6):633-647

Russel H Morgan Department of Radiology & Radiology Science, Johns Hopkins Medical Institutions, 601 North Caroline Street/JHOC 3235, Baltimore, MD 21287, USA.

This article discusses the value of F-fluoro-2-deoxyglucose PET/CT imaging biomarkers in head and neck squamous cell carcinoma. F-fluoro-2-deoxyglucose PET/CT is valuable at baseline staging, radiotherapy planning, therapy response assessment and in the follow-up of patients with head and neck squamous cell carcinoma. Maximum and peak standardized uptake value (SUV and SUV), metabolic tumor volume and total lesion glycolysis are the common F-fluoro-2-deoxyglucose quantitative parameters that have been studied, along with qualitative assessments. Read More

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http://dx.doi.org/10.2217/iim.12.60DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3587845PMC
December 2012
3 Reads
25 Citations

Biomarkers for the clinical evaluation of the cognitively impaired elderly: amyloid is not enough.

Imaging Med 2012 Jun;4(3):343-357

Departments of Radiology & Neurosciences, University of California, 9500 Gilman Drive, MC 0949, La Jolla, San Diego, CA 92093-0949, USA.

The number of elderly patients seeking clinical treatment for memory problems will rise sharply in coming years as our population ages. These patients present a challenge for diagnosis and prognosis since cognitive problems in older patients can arise from many etiologies, some of which are curable. With the development of clinically available biomarkers for detecting Alzheimer's disease pathology in living patients, evaluation of cognitively impaired elderly patients is about to undergo a major paradigm shift. Read More

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http://dx.doi.org/10.2217/iim.12.27DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3573528PMC
June 2012
1 Read

Cord blood endothelial progenitor cells as therapeutic and imaging probes.

Imaging Med 2012 Aug;4(4):477-490

Cellular & Molecular Imaging Laboratory, Department of Radiology, Henry Ford Hospital, 1 Ford Place, 2F, Box 82, Detroit, MI 48202, USA.

Numerous studies demonstrated that neovascularization processes associated with severe tissue ischemia commonly found in conditions such as cardiovascular disorders and tumor growth occur via angiogenic and vasculogenic mechanisms. Over the past decade, it has been demonstrated that endothelial progenitor cells (EPCs) play a significant role in neo-angiogenic and neovasculogenic processes. Due to their ability to self-renew, circulate, home to the ischemic sites and differentiate into mature endothelial cells, EPCs derived from various sources hold enormous potential to be used as therapeutic agents in pro- or anti-angiogenic strategies for the treatment of ischemic and tumor conditions, respectively. Read More

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http://dx.doi.org/10.2217/iim.12.35DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3513932PMC
August 2012
3 Reads

Intravascular multispectral optoacoustic tomography of atherosclerosis: prospects and challenges.

Imaging Med 2012 Jun;4(3):299-310

Institute for Biological & Medical Imaging, Helmholtz Zentrum München & Technische Universität München, Munich, Germany.

The progression of atherosclerosis involves complex changes in the structure, composition and biology of the artery wall. Currently, only anatomical plaque burden is routinely characterized in living patients, whereas compositional and biological changes are mostly inaccessible. However, anatomical imaging alone has proven to be insufficient for accurate diagnostics of the disease. Read More

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http://dx.doi.org/10.2217/iim.12.20DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3493570PMC
June 2012
8 Reads

Role of CT perfusion imaging in the diagnosis and treatment of vasospasm.

Imaging Med 2011 Jun;3(3):287-297

Division of Interventional Neuroradiology, Department of Neurosurgery, Weill Cornell Medical College, NewYork-Presbyterian Hospital, NY, USA.

The current role of CT perfusion (CTP) imaging in the diagnosis and treatment of vasospasm in the setting of aneurysmal subarachnoid hemorrhage is discussed in this article, with specific attention directed towards defining the terminology of vasospasm and delayed cerebral ischemia. A commonly used CTP technique in clinical practice is described. A review of the literature regarding the usefulness of CTP for the diagnosis of vasospasm and its role in guiding treatment are discussed. Read More

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http://dx.doi.org/10.2217/iim.11.19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3389822PMC
June 2011
6 Reads

An update on brain imaging in parkinsonian dementia.

Imaging Med 2012 Apr;4(2):201-213

University of Michigan, Ann Arbor, MI, USA.

Disturbances of cognition are frequent in Parkinson's disease (PD). Unlike severe loss of dopamine early in PD, extensive cholinergic losses have been consistently reported in PD with dementia. Cholinergic imaging suggests that basal forebrain cholinergic system degeneration appears early in PD and worsens with dementia development. Read More

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http://dx.doi.org/10.2217/iim.12.10DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3387991PMC
April 2012
4 Reads

Tracking stem cells for cardiovascular applications in vivo: focus on imaging techniques.

Imaging Med 2011 Aug;3(4):473-486

Russell H Morgan Department of Radiology & Radiological Science, Johns Hopkins University, Baltimore, MD, USA.

Despite rapid translation of stem cell therapy into clinical practice, the treatment of cardiovascular disease using embryonic stem cells, adult stem and progenitor cells or induced pluripotent stem cells has not yielded satisfactory results to date. Noninvasive stem cell imaging techniques could provide greater insight into not only the therapeutic benefit, but also the fundamental mechanisms underlying stem cell fate, migration, survival and engraftment in vivo. This information could also assist in the appropriate choice of stem cell type(s), delivery routes and dosing regimes in clinical cardiovascular stem cell trials. Read More

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http://dx.doi.org/10.2217/iim.11.33DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3265127PMC
August 2011
2 Reads

Neurological imaging: statistics behind the pictures.

Authors:
Ivo D Dinov

Imaging Med 2011 Aug;3(4):423-432

SOCR Resource and Laboratory of Neuro Imaging, UCLA Statistics, 8125 Mathematical Science Bldg, Los Angeles, CA 90095, USA, Tel.: +1 310 825 8430.

Neurological imaging represents a powerful paradigm for investigation of brain structure, physiology and function across different scales. The diverse phenotypes and significant normal and pathological brain variability demand reliable and efficient statistical methodologies to model, analyze and interpret raw neurological images and derived geometric information from these images. The validity, reproducibility and power of any statistical brain map require appropriate inference on large cohorts, significant community validation, and multidisciplinary collaborations between physicians, engineers and statisticians. Read More

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http://dx.doi.org/10.2217/iim.11.37DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3237637PMC
August 2011
2 Reads

What challenges must be overcome before ultrasound elasticity imaging is ready for the clinic?

Imaging Med 2011 Aug;3(4):433-444

Department of Biomedical Engineering, Duke University, Durham, NC 27708, USA.

Ultrasound elasticity imaging has been a research interest for the past 20 years with the goal of generating novel images of soft tissues based on their material properties (i.e., stiffness and viscosity). Read More

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http://dx.doi.org/10.2217/iim.11.41DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3235674PMC
August 2011
2 Reads

Advanced MRI of articular cartilage.

Imaging Med 2011 Oct;3(5):541-555

Department of Radiology, Stanford University, CA, USA.

Musculoskeletal MRI is advancing rapidly, with innovative technology and significant potential for immediate clinical impact. In particular, cartilage imaging has become a topic of increasing interest as our aging population develops diseases such as osteoarthritis. Advances in MRI hardware and software have led to increased image quality and tissue contrast. Read More

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http://dx.doi.org/10.2217/iim.11.43DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3230859PMC
October 2011
3 Reads

Oncologic Angiogenesis Imaging in the clinic---how and why.

Imaging Med 2011 Sep;3(4):445-457

The ability to control the growth of new blood vessels would be an extraordinary therapeutic tool for many disease processes. Too often, the promises of discoveries in the basic science arena fail to translate to clinical success. While several anti angiogenic therapeutics are now FDA approved, the envisioned clinical benefits have yet to be seen. Read More

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http://dx.doi.org/10.2217/iim.11.31DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3224985PMC
September 2011
3 Reads

Diffusion-Tensor MRI Based Skeletal Muscle Fiber Tracking.

Imaging Med 2011 Nov;3(6):675-687

Institute of Imaging Science, Vanderbilt University, Nashville TN USA ; Department of Radiology and Radiological Sciences, Vanderbilt University, Nashville TN USA ; Department of Biomedical Engineering, Vanderbilt University, Nashville TN USA ; Program in Chemical and Physical Biology, Vanderbilt University, Nashville TN USA ; Department of Electrical Engineering and Computer Science, Vanderbilt University, Nashville TN USA.

A skeletal muscle's function is strongly influenced by the internal organization and geometric properties of its fibers, a property known as muscle architecture. Diffusion-tensor magnetic resonance imaging-based fiber tracking provides a powerful tool for non-invasive muscle architecture studies, has three-dimensional sensitivity, and uses a fixed frame of reference. Significant advances have been made in muscle fiber tracking technology, including defining seed points for fiber tracking, quantitatively characterizing muscle architecture, implementing denoising procedures, and testing validity and repeatability. Read More

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http://dx.doi.org/10.2217/iim.11.60DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4241547PMC
November 2011
1 Read

Diffusion tensor imaging of white matter pathology in the mouse brain.

Authors:
Jiangyang Zhang

Imaging Med 2010 Dec;2(6):623-632

Department of Radiology, Johns Hopkins University School of Medicine, 217 Traylor Bldg, 720 Rutland Ave., Baltimore, MD, 21205, USA, Tel.: +1 410 502 9856.

Diffusion tensor imaging has been increasingly used for studying white matter pathology in rodent models of neurological diseases. Here, applications of diffusion tensor imaging in detecting major and subtle white matter pathology in the mouse CNS are reviewed, followed by several technical details that may be helpful in designing studies that involve diffusion tensor imaging of rodent brain and spinal cord. Read More

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http://dx.doi.org/10.2217/iim.10.60DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3105628PMC
December 2010
2 Reads

Image reconstruction for PET/CT scanners: past achievements and future challenges.

Imaging Med 2010 Oct;2(5):529-545

Department of Radiology, University of Washington, Seattle WA, USA.

PET is a medical imaging modality with proven clinical value for disease diagnosis and treatment monitoring. The integration of PET and CT on modern scanners provides a synergy of the two imaging modalities. Through different mathematical algorithms, PET data can be reconstructed into the spatial distribution of the injected radiotracer. Read More

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http://dx.doi.org/10.2217/iim.10.49DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3039307PMC
October 2010
1 Read

3D gradient echo sequence provides better images in contrast-enhanced imaging of the pituitary gland at 3 T.

Authors:
Ali Syed Arbab

Imaging Med 2010 Apr;2(2):129-130

Henry Ford Hospital, Cellular & Molecular Imaging Laboratory, Department of Radiology, 1 Ford Place, 2F Detroit, MI 48202, USA, Tel.: +1 313 874 4435, ,

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3027067PMC
April 2010
6 Reads

How have developments in molecular imaging techniques furthered schizophrenia research?

Imaging Med 2009 Dec;1(2):135-153

Department of Psychiatry, Columbia University and New York State Psychiatric Institute, 1051 Riverside Drive, Unit 31, New York, NY 10032, USA.

Molecular imaging techniques have led to significant advances in understanding the pathophysiology of schizophrenia and contributed to knowledge regarding potential mechanisms of action of the drugs used to treat this illness. The aim of this article is to provide a review of the major findings related to the application of molecular imaging techniques that have furthered schizophrenia research. This article focuses specifically on neuroreceptor imaging studies with PET and SPECT. Read More

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http://dx.doi.org/10.2217/IIM.09.22DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3020795PMC
December 2009
2 Reads

MRI in the early identification and classification of high-risk atherosclerotic carotid plaques.

Imaging Med 2010 Feb;2(1):63-75

Department of Surgery, Vascular Imaging Lab, University of Washington, 815 Mercer Street, Box 358050, Seattle, WA 98109, USA, Tel.: +1 206 543 3061, ,

Stroke is a leading cause of mortality and long-term morbidity. As a means for stroke prevention, an estimated 99,000 carotid endarterectomy procedures were performed in the USA in 2006. Traditionally, the degree of luminal stenosis has been used as a marker of the stage of atherosclerosis and as an indication for surgical intervention. Read More

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http://dx.doi.org/10.2217/iim.09.33DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2953811PMC
February 2010
2 Reads

Computer-aided diagnostic models in breast cancer screening.

Imaging Med 2010 Jun;2(3):313-323

Industrial & Systems Engineering Department, University of Wisconsin, Madison, WI, USA.

Mammography is the most common modality for breast cancer detection and diagnosis and is often complemented by ultrasound and MRI. However, similarities between early signs of breast cancer and normal structures in these images make detection and diagnosis of breast cancer a difficult task. To aid physicians in detection and diagnosis, computer-aided detection and computer-aided diagnostic (CADx) models have been proposed. Read More

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http://www.futuremedicine.com/doi/abs/10.2217/iim.10.24
Publisher Site
http://dx.doi.org/10.2217/IIM.10.24DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2936490PMC
June 2010
10 Reads

Imaging to optimize liver tumor ablation.

Imaging Med 2010 Aug;2(4):433-443

Memorial Sloan-Kettering Cancer Center, NY, USA.

Surgical resection remains the ideal treatment for hepatocellular carcinoma and metastasis to the liver. Many alternatives are available for treatment of nonsurgical candidates. Regardless of treatment, optimizing imaging in the pretreatment, treatment and post-treatment settings is critical in order to lower the rates of local tumor progression and maximize the effectiveness of treatment that may result in prolonged survival. Read More

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http://dx.doi.org/10.2217/IIM.10.32DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5102511PMC
August 2010
8 Reads

Radiation dose reduction in computed tomography: techniques and future perspective.

Imaging Med 2009 Oct;1(1):65-84

Department of Radiology, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA.

Despite universal consensus that computed tomography (CT) overwhelmingly benefits patients when used for appropriate indications, concerns have been raised regarding the potential risk of cancer induction from CT due to the exponentially increased use of CT in medicine. Keeping radiation dose as low as reasonably achievable, consistent with the diagnostic task, remains the most important strategy for decreasing this potential risk. This article summarizes the general technical strategies that are commonly used for radiation dose management in CT. Read More

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http://dx.doi.org/10.2217/iim.09.5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3271708PMC
October 2009
2 Reads
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