6,160 results match your criteria Imaging in Lung Cancer Staging


Development of sodium fluoride PET response criteria for solid tumours (NAFCIST) in a clinical trial of radium-223 in osteosarcoma: from RECIST to PERCIST to NAFCIST.

ESMO Open 2019 28;4(1):e000439. Epub 2019 Feb 28.

Department of Investigational Cancer Therapeutics, Division of Cancer Medicine and Division of Pediatrics, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.

Purpose: The development of osteosarcoma therapeutics has been challenging, in part because of the lack of appropriate criteria to evaluate responses. We developed a novel criteria in a clinical trial of radium-223 dichloride (RaCl) for response assessment in osteosarcoma, NAFCIST (NaF PET response Criteria in Solid Tumors).

Experimental Design: Patients received one to six cycles of RaCl, and cumulative doses varied from 6. Read More

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http://dx.doi.org/10.1136/esmoopen-2018-000439DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6435244PMC
February 2019
1 Read

FAPI-PET/CT: Mean intensity of tracer-uptake (SUV) in 28 different kinds of cancer.

J Nucl Med 2019 Apr 6. Epub 2019 Apr 6.

University Hospital Heidelberg, Germany.

The recent development of quinoline based positron-emission-tomography (PET)-tracers that act as fibroblast-activation-protein inhibitors (FAPIs) demonstrated promising preclinical and clinical results. FAP is overexpressed by cancer associated fibroblasts (CAFs) of several tumor entities. Here we quantify the tumor-uptake in FAPI-PET/CT of various primary and metastatic tumors to identify the most promising indications for future application. Read More

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http://dx.doi.org/10.2967/jnumed.119.227967DOI Listing
April 2019
1 Read

Every distant deposit is not a metastasis: Synchronous primaries do exist.

Indian J Cancer 2019 Jan-Mar;56(1):70-73

Department of Medical Oncology, Kidwai Memorial Institute of Oncology, Bengaluru, Karnataka, India.

Background: Synchronous occurrence of two malignant tumors is a rare event. With increasing use of sophisticated imaging modalities for staging, synchronous multiple tumors are more commonly detected now. Assuming the second primary malignancy as metastasis will change the intent of treatment from curative to palliative, greater awareness among oncologists is of paramount importance. Read More

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http://dx.doi.org/10.4103/ijc.IJC_637_17DOI Listing

The Role of F-FDG PET/CT in Detecting Ovarian Cancer Recurrence in Patients with Elevated CA-125 Levels

Mol Imaging Radionucl Ther 2019 Mar;28(1):8-14

Aydın Adnan Menderes University Faculty of Medicine, Department of Nuclear Medicine, Aydın, Turkey

Objectives: To investigate the role of F-FDG positron emission tomography/computed tomography (PET/CT) in detection of recurrence in ovarian cancer patients with increased CA-125 levels.

Methods: Fifty-two patients (30-80 years old, mean: 58.5±10. Read More

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http://dx.doi.org/10.4274/mirt.galenos.2018.00710DOI Listing
March 2019
2 Reads

Patient preferences for whole-body MRI or conventional staging pathways in lung and colorectal cancer: a discrete choice experiment.

Eur Radiol 2019 Apr 1. Epub 2019 Apr 1.

Research Department of Applied Health Research, University College London, 1-19 Torrington Place, London, WC1E 6BT, UK.

Objectives: To determine the importance placed by patients on attributes associated with whole-body MRI (WB-MRI) and standard cancer staging pathways and ascertain drivers of preference.

Methods: Patients recruited to two multi-centre diagnostic accuracy trials comparing WB-MRI with standard staging pathways in lung and colorectal cancer were invited to complete a discrete choice experiment (DCE), choosing between a series of alternate pathways in which 6 attributes (accuracy, time to diagnosis, scan duration, whole-body enclosure, radiation exposure, total scan number) were varied systematically. Data were analysed using a conditional logit regression model and marginal rates of substitution computed. Read More

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http://dx.doi.org/10.1007/s00330-019-06153-4DOI Listing

Lung cancer: diagnosis and management: summary of updated NICE guidance.

BMJ 2019 Mar 28;364:l1049. Epub 2019 Mar 28.

Queen's University Belfast; and Belfast Health and Social Care Trust, Belfast, UK.

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http://dx.doi.org/10.1136/bmj.l1049DOI Listing

Preliminary clinical assessment of dynamic F-fluorodeoxyglucose positron emission tomography/computed tomography for evaluating lymph node metastasis in patients with lung cancer: a prospective study.

Ann Nucl Med 2019 Mar 25. Epub 2019 Mar 25.

Department of Radiology, Tokushima University Hospital, 2-50-1, Kuramoto-cho, Tokushima City, Tokushima, 770-8503, Japan.

Objective: We assessed the diagnostic capacity of dynamic fluorine-18-fluorodeoxyglucose positron emission tomography/computed tomography (F-FDG PET/CT) and dual-time-point (DTP) PET/CT to explore the optimal scan timing for nodal staging in lung cancer.

Methods: Thirty-four patients with lung cancer underwent dynamic and consecutive DTP PET/CT scans. Two readers visually evaluated FDG uptake within each lymph node (LN) and pulmonary artery (metastatic LN: n = 10; nonmetastatic LN: n = 121). Read More

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http://dx.doi.org/10.1007/s12149-019-01350-zDOI Listing
March 2019
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[Application of Metabolic Parameters Measured by ¹⁸F-FDG PET/CT in the Evaluation of the Prognosis of Non-small Cell Lung Cancer].

Zhongguo Fei Ai Za Zhi 2019 Mar;22(3):167-172

Department of Nuclear Medicine, the Affiliated Hospital of Qingdao University, Qingdao 266100, China.

Tumor-node-metastasis (TNM) staging system is the most important basis for making therapeutic decisions and predicting prognosis of lung cancer patients. The metabolic parameters including standardized uptake value (SUV), metabolic tumor volume (MTV) and total lesion glycolysis (TLG) measured by ¹⁸F-fluorodeoxyglucose-positron emission tomography (¹⁸F-FDG PET/CT) associate with tumor aggressiveness and can provide additional prognostic information. A new staging methodology combines the conventional cTNM with the metabolic tumor burden quantified from the PET images is a better predictor of overall survival with superior stratifying power may help oncologists to make better treatment plans. Read More

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http://dx.doi.org/10.3779/j.issn.1009-3419.2019.03.09DOI Listing
March 2019
2 Reads

Spectral CT and its specific values in the staging of patients with non-small cell lung cancer: technical possibilities and clinical impact.

Clin Radiol 2019 Mar 21. Epub 2019 Mar 21.

Department of Radiology, Charité University Medicine Berlin, Campus Virchow Klinikum, Berlin, Germany; Department of Radiology, University Hospital Munich, Ludwig-Maximilians University (LMU), Munich, Germany. Electronic address:

Aim: To investigate how spectral computed tomography (SCT) values impact the staging of non-small cell lung cancer (NSCLC) patients.

Materials And Methods: One hundred and thirteen patients with confirmed NSCLC were included in a prospective cohort study. All patients underwent single-phase contrast-enhanced SCT (using the fast tube voltage switching technique, 80-140 kV). Read More

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http://dx.doi.org/10.1016/j.crad.2019.02.010DOI Listing
March 2019
1 Read

Semantic segmentation and detection of mediastinal lymph nodes and anatomical structures in CT data for lung cancer staging.

Int J Comput Assist Radiol Surg 2019 Mar 19. Epub 2019 Mar 19.

Medical Technology Department, SINTEF, Trondheim, Norway.

Purpose: Accurate lung cancer diagnosis is crucial to select the best course of action for treating the patient. From a simple chest CT volume, it is necessary to identify whether the cancer has spread to nearby lymph nodes or not. It is equally important to know precisely where each malignant lymph node is with respect to the surrounding anatomical structures and the airways. Read More

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http://dx.doi.org/10.1007/s11548-019-01948-8DOI Listing

Imaging in pleural mesothelioma: A review of the 14th International Conference of the International Mesothelioma Interest Group.

Lung Cancer 2019 Apr 28;130:108-114. Epub 2018 Nov 28.

Department of Radiology, The Ottawa Hospital, Ottawa, Ontario, Canada.

Mesothelioma patients rely on the information their clinical team obtains from medical imaging. Whether x-ray-based computed tomography (CT) or magnetic resonance imaging (MRI) based on local magnetic fields within a patient's tissues, different modalities generate images with uniquely different appearances and information content due to the physical differences of the image-acquisition process. Researchers are developing sophisticated ways to extract a greater amount of the information contained within these images. Read More

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http://dx.doi.org/10.1016/j.lungcan.2018.11.033DOI Listing
April 2019
1 Read

Performance characteristics of EUS-FNA biopsy for adrenal lesions: A meta-analysis.

Endosc Ultrasound 2019 Mar 12. Epub 2019 Mar 12.

Indiana University School of Medicine, Indianapolis, IN, USA.

Background And Objective: The role of EUS-FNA biopsy (EUS-FNAB) for detection of metastatic lesions (mets) to adrenals has not been evaluated systematically. Our aim is to systematically evaluate the performance characteristics of EUS-FNAB in detecting metastasis to the adrenal glands.

Materials And Methods: We performed a systematic search on PubMed and OvidSP from January 1990 to July 2016 using various search terms for EUS and adrenal lesion. Read More

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http://dx.doi.org/10.4103/eus.eus_42_18DOI Listing
March 2019
1 Read

Sodium-glucose cotransporters: new targets of cancer therapy?

Arh Hig Rada Toksikol 2018 Dec;69(4):278-285

Molecular Toxicology Unit, Institute for Medical Research and Occupational Health, Zagreb, Croatia.

Glucose, the key source of metabolic energy, is imported into cells by two categories of transporters: 1) facilitative glucose transporters (GLUTs) and 2) secondary active sodium-glucose cotransporters (SGLTs). Cancer cells have an increased demand for glucose uptake and utilisation compared to normal cells. Previous studies have demonstrated the overexpression of GLUTs, mainly GLUT1, in many cancer types. Read More

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http://content.sciendo.com/view/journals/aiht/69/4/article-p
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http://dx.doi.org/10.2478/aiht-2018-69-3204DOI Listing
December 2018
3 Reads
0.727 Impact Factor

Diffusion-weighted magnetic resonance imaging is useful for the response evaluation of chemotherapy and/or radiotherapy to recurrent lesions of lung cancer.

Transl Oncol 2019 May 9;12(5):699-704. Epub 2019 Mar 9.

Department of Thoracic Surgery, Kanazawa Medical University, Ishikawa, Japan.

Diffusion-weighted magnetic resonance imaging (DWI) has been reported to be useful for the assessment of lung cancer staging. It is uncertain whether DWI is more accurate for the response evaluation of chemotherapy and/or radiotherapy compared to computed tomography (CT). The purpose of this study is to compare the response evaluation of DWI for chemotherapy and/or radiotherapy to recurrent tumors of lung cancer with that of CT which is a standard tool in RECIST (Response Evaluation Criteria in Solid Tumours). Read More

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http://dx.doi.org/10.1016/j.tranon.2019.02.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6411607PMC
May 2019
4 Reads

Prediction of pleural invasion using different imaging tools in non-small cell lung cancer.

Ann Transl Med 2019 Jan;7(2):33

Department of Surgery, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan.

Clinical staging of non-small cell lung cancer (NSCLC) is used for planning therapeutic strategies. In particular, pleural invasion is regarded as an indicator for upstaging to T2 or T3 in the current 8th TNM staging system; patients with pleural invasion should be indicated for lobectomy rather than sublobar resection. Therefore, accurate preoperative prediction of pleural invasion is important for surgical planning. Read More

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http://dx.doi.org/10.21037/atm.2019.01.15DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6381262PMC
January 2019
3 Reads

Unexpected significant findings non-related to prostate cancer identified using combined prostate-specific membrane antigen positron emission tomography/CT and diagnostic CT scan in primary staging for prostate cancer.

J Med Imaging Radiat Oncol 2019 Mar 6. Epub 2019 Mar 6.

Wesley Medical Imaging, The Wesley Hospital, Brisbane, Queensland, Australia.

Introduction: There is increasing scientific evidence that whole-body Gallium-68 prostate-specific membrane antigen ( Ga-PSMA) positron emission tomography/computed tomography (PET/CT) improves the sensitivity of prostate cancer detection above standard staging radiology. Diagnostic IV-contrasted CT scanning offers high-quality recognition and delineation of organs and structures with a high sensitivity and specificity for diagnoses of many non-prostate pathologies. At our institution, imaging for prostate cancer staging and restaging involves a Ga-PSMA PET/CT scan combined with a diagnostic IV-contrasted CT scan of the head, neck, chest, abdomen and pelvis. Read More

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http://dx.doi.org/10.1111/1754-9485.12864DOI Listing
March 2019
2 Reads

[Health economics analysis for 18F-fluorodeoxyglucose positron-emission tomography compared with computed tomography in lung cancer].

Zhong Nan Da Xue Xue Bao Yi Xue Ban 2019 Feb;44(2):216-221

PET-CT Center, Second Xiangya Hospital, Central South University, Changsha 410011, China.

Compared with conventional imaging, 18F-fluorodeoxyglucose positron-emission tomography compared with computed tomography (18F-FDG PET/CT) possesses higher sensitivity and specificity in the diagnosis of solitary pulmonary nodule (SPN) and lung cancer. From the perspective of health economics, PET/CT is more suitable strategy for diagnose of SPN with intermediate probability of malignancy, and has good health economics value in preoperative staging diagnosis and follow-up after radiotherapy and chemotherapy of lung cancer. The evaluation method, effect index and comparison method used in the health economics research of PET/CT for lung cancer diagnosis and treatment are cost-effect analysis, life year and incremental cost-effect ratio, respectively. Read More

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http://dx.doi.org/10.11817/j.issn.1672-7347.2019.02.015DOI Listing
February 2019
2 Reads

Centrally-located lung cancer and risk of occult nodal disease: an objective evaluation of multiple definitions of tumor centrality with a dedicated imaging software.

Eur Respir J 2019 Feb 28. Epub 2019 Feb 28.

Department of Pulmonary Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.

Introduction: Current guidelines recommend invasive mediastinal staging in patients with centrally located radiographic stage T1N0M0 non-small cell lung cancer. The lack of a specific definition of central tumor has resulted in discrepancies among guidelines and heterogeneity in practice patterns.

Methods: Our objective was to study specific definitions of tumor centrality and their association with occult nodal disease. Read More

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http://dx.doi.org/10.1183/13993003.02220-2018DOI Listing
February 2019
1 Read

A critical review of the chest CT scans performed to detect asymptomatic synchronous metastasis in new and recurrent breast cancers.

World J Surg Oncol 2019 Feb 23;17(1):40. Epub 2019 Feb 23.

Breast and Endocrine Surgery Unit, Maroondah Hospital, Eastern Health, Davey Drive, Ringwood East, Melbourne, VIC, 3135, Australia.

Background: Chest computed tomography (CTC) has now replaced chest X-ray (CXR) as the first choice of investigation to stage breast cancers in most centers in Australia. Routine staging is not recommended in early breast cancers (EBCs). This recommendation is based largely on the use of conventional tests like CXR as staging investigations (SIs). Read More

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http://dx.doi.org/10.1186/s12957-019-1584-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6387737PMC
February 2019
3 Reads

Empiric Radiotherapy for Lung Cancer Collaborative Group multi-institutional evidence-based guidelines for the use of empiric stereotactic body radiation therapy for non-small cell lung cancer without pathologic confirmation.

Transl Lung Cancer Res 2019 Feb;8(1):5-14

Department of Radiation Oncology, University of Maryland School of Medicine, Baltimore, MD, USA.

The standard of care for managing early stage non-small cell lung cancer (NSCLC) is definitive surgical resection. Stereotactic body radiation therapy (SBRT) has become the standard treatment for patient who are medically inoperable, and it is increasingly being considered as an option in operable patients. With the growing use of screening thoracic CT scans for patients with a history of heavy smoking, as well as improved imaging capabilities, the discovery of small lung nodes has become a common dilemma. Read More

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http://dx.doi.org/10.21037/tlcr.2018.12.12DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6351405PMC
February 2019
2 Reads

Gross handling of pulmonary resection specimen: maintaining the 3-dimensional orientation.

J Thorac Dis 2019 Jan;11(Suppl 1):S37-S44

Department of Pathology Amsterdam University Medical Centers, VU University Medical Center, De Boelelaan 1117, Amsterdam, The Netherlands.

There is limited literature on the gross handling of lung resection specimens. Microscopic examination of the specimen, TNM staging and predictive biomarker testing are fully dependent on an adequate gross handling. In this paper, we present a 3-dimensional (3D) grossing method of oncological lung resection specimens, which ensures proper fixation of the tumor tissue, but also enables accurate correlation with the pre-surgical imaging. Read More

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http://dx.doi.org/10.21037/jtd.2018.12.36DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6353737PMC
January 2019

Does FDG PET/CT have a role in determining adjuvant chemotherapy in surgical margin-negative stage IA non-small cell lung cancer patients?

J Cancer Res Clin Oncol 2019 Apr 13;145(4):1021-1026. Epub 2019 Feb 13.

Department of Thoracic and Cardiovascular Surgery, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.

Purpose: To evaluate the prognostic value of FDG PET/CT metabolic parameter compared to clinico-pathological risk factors in surgical margin-negative stage IA non-small cell lung cancer (NSCLC) patients.

Methods: 167 patients with consecutive FDG PET/CT scans from 2009 to 2015 performed for staging of NSCLC stage IA with plans for curative surgery were retrospectively reviewed. Maximum standardized uptake value (SUVmax) of primary tumor and mean SUV of liver were acquired from PET/CT. Read More

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http://dx.doi.org/10.1007/s00432-019-02858-7DOI Listing
April 2019
1 Read

Lung cancer imaging methods in China from 2005 to 2014: A national, multicenter study.

Thorac Cancer 2019 Apr 8;10(4):708-714. Epub 2019 Feb 8.

Department of Diagnostic Radiology, National Cancer Center/ National Clinical Research Center for Cancer/ Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

Background: The study was conducted to examine changes in diagnostic and staging imaging methods for lung cancer in China over a 10-year period and to determine the relationships between such changes and socioeconomic development.

Methods: This was a hospital-based, nationwide, multicenter retrospective study of primary lung cancer cases. The data were extracted from the 10-year primary lung cancer databases at eight tertiary hospitals from various geographic areas in China. Read More

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http://doi.wiley.com/10.1111/1759-7714.12988
Publisher Site
http://dx.doi.org/10.1111/1759-7714.12988DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6449240PMC
April 2019
23 Reads
1.126 Impact Factor

Bone marrow biopsy in the initial staging of Ewing sarcoma: Experience from a single institution.

Pediatr Blood Cancer 2019 Feb 5:e27653. Epub 2019 Feb 5.

Chemotherapy Section, IRCCS-Rizzoli Orthopaedic Institute, Bologna, Italy.

Background: Ewing sarcoma (ES) is the second most common bone tumor in adolescents and children. Staging workup for ES includes imaging and bone marrow biopsy (BMB). The effective role of BMB is now under discussion. Read More

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http://dx.doi.org/10.1002/pbc.27653DOI Listing
February 2019
1 Read
2.562 Impact Factor

Correlations of Twist Expression with Pathological and Computed Tomography (CT) Characteristics and Prognosis of Non-Small Cell Lung Cancer (NSCLC).

Med Sci Monit 2019 Feb 4;25:977-983. Epub 2019 Feb 4.

Department of Radiology, Shengli Oilfield Central Hospital, Dongying, Shandong, China (mainland).

BACKGROUND The aim of this study was to assess the correlations of Twist expression with pathological and computed tomography (CT) characteristics and prognosis of non-small cell lung cancer (NSCLC). MATERIAL AND METHODS We enrolled 120 patients with lung cancer who underwent CT examination. The Twist protein expression level was detected in 120 cases of cancer tissues and a control group using immunohistochemical method. Read More

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http://dx.doi.org/10.12659/MSM.912674DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6371739PMC
February 2019
1 Read

Population-based assessment of the national comprehensive cancer network recommendations for baseline imaging of hepatocellular carcinoma.

Med Oncol 2019 Feb 1;36(3):26. Epub 2019 Feb 1.

Department of Oncology, University of Calgary, Tom Baker Cancer Centre, 1331 29 ST NW, Calgary, AB, T2N 4N2, Canada.

This analysis aims to evaluate the performance characteristics of alternative baseline imaging thresholds in a cohort of hepatocellular carcinoma (HCC) patients from the Surveillance, Epidemiology, and End Results (SEER) database. HCC patients within the SEER database (2010-2015) who had complete information on clinical T and N stages as well as complete information on metastatic sites were eligible for the current study. Various performance characteristics associated with baseline imaging were investigated, including specificity, sensitivity, positive likelihood ratio (LR), negative LR, number needed to investigate (NNI), negative predictive value (NPV), positive predictive value (PPV), and accuracy. Read More

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http://dx.doi.org/10.1007/s12032-019-1248-2DOI Listing
February 2019
2.058 Impact Factor

[Clinical significance of recombinant virus-specific detection for viable circulating tumor cells in lung cancer patients].

Zhonghua Jie He He Hu Xi Za Zhi 2019 Feb;42(2):101-105

Department of Respiratory and Critical Care Medicine, Beijing Anzhen Hospital, Capital Medical University, Beijing 100029, China.

To investigate the clinical significance of recombinant virus-specific detection for detecting viable circulating tumor cell (CTC) in lung cancer patients. From June 2017 to August 2018, 63 lung cancer patients diagnosed by imaging and pathology at the Department of Respiratory and Critical Care Medicine, Beijing Anzhen Hospital were recruited for this study, including 38 cases of adenocarcinoma, 13 squamous cell carcinoma, and 12 small cell carcinoma. The patients consisted of 36 males and 27 females, with an average age of (65±11) years. Read More

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http://dx.doi.org/10.3760/cma.j.issn.1001-0939.2019.02.005DOI Listing
February 2019
2 Reads

M1b Disease in the 8th Edition of TNM Staging of Lung Cancer: Pattern of Single Extrathoracic Metastasis and Clinical Outcome.

Oncologist 2019 Jan 29. Epub 2019 Jan 29.

Department of Radiology, Brigham and Women's Hospital and Dana-Farber Cancer Institute, Boston, Massachusetts, USA

Background: The 8th edition of TNM staging of non-small cell lung cancer (NSCLC) has revised M classification and defined M1b disease with single extrathoracic metastasis, which is distinguished from M1c with multiple extrathoracic metastases. We investigated the prevalence, characteristics, and overall survival (OS) of M1b disease in patients with stage IV NSCLC.

Methods: The study reviewed the medical records and imaging studies of 567 patients with stage IV NSCLC to determine M stage using the 8th edition of TNM staging. Read More

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http://dx.doi.org/10.1634/theoncologist.2018-0596DOI Listing
January 2019
1 Read

Lung and Pancreatic Tumor Characterization in the Deep Learning Era: Novel Supervised and Unsupervised Learning Approaches.

IEEE Trans Med Imaging 2019 Jan 23. Epub 2019 Jan 23.

Risk stratification (characterization) of tumors from radiology images can be more accurate and faster with computeraided diagnosis (CAD) tools. Tumor characterization through such tools can also enable non-invasive cancer staging, prognosis, and foster personalized treatment planning as a part of precision medicine. In this study, we propose both supervised and unsupervised machine learning strategies to improve tumor characterization. Read More

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http://dx.doi.org/10.1109/TMI.2019.2894349DOI Listing
January 2019
8 Reads

Resected Pure Small Cell Lung Carcinomas and Combined Small Cell Lung Carcinomas: Histopathology Features, Imaging Features, and Prognoses.

AJR Am J Roentgenol 2019 Apr 23;212(4):773-781. Epub 2019 Jan 23.

3 Department of Thoracic Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.

Objective: The objective of our study was to investigate histopathology features, imaging features, and prognoses of surgically resected pure small cell lung carcinomas (SCLCs) and combined SCLCs.

Materials And Methods: Forty-one patients with a pure SCLC or a combined SCLC underwent preoperative chest CT and F-FDG PET/CT and subsequent surgical resection. The clinicopathologic findings were noted by reviewing the electronic medical records. Read More

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http://dx.doi.org/10.2214/AJR.18.20519DOI Listing
April 2019
3 Reads

Impact of different image reconstructions on PET quantification in non-small cell lung cancer: a comparison of adenocarcinoma and squamous cell carcinoma.

Br J Radiol 2019 Apr 26;92(1096):20180792. Epub 2019 Feb 26.

1 Department of Nuclear Medicine, University Hospital Zurich / University of Zurich , Switzerland.

Objective:: Positron emission tomography (PET) using F-fludeoxyglucose (F-FDG) is an established imaging modality for tumor staging in patients with non-small cell lung cancer (NSCLC). There is a growing interest in using F-FDG PET for therapy response assessment in NSCLC which relies on quantitative PET parameters such as standardized uptake values (SUV). Different reconstruction algorithms in PET may affect SUV. Read More

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http://dx.doi.org/10.1259/bjr.20180792DOI Listing
April 2019
3 Reads

Left systematic mediastinal lymph node dissection.

Multimed Man Cardiothorac Surg 2019 01 2;2019. Epub 2019 Jan 2.

General Surgery Department General Hospital of Athens "Evangelismos'' Athens, Greece.

Sampling, or systematic mediastinal lymph node dissection, is the standard-of-care surgical treatment for early stage non-small cell lung cancer, according to guidelines from the European Society of Thoracic Surgeons. Lymph node status defines disease status and patients' prognosis. In this  video tutorial, a radical ipsilateral mediastinal lymph node dissection in a man suffering from a left, centrally located lung adenocarcinoma is presented. Read More

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http://dx.doi.org/10.1510/mmcts.2019.001DOI Listing
January 2019
2 Reads

SOX9 is a dose-dependent metastatic fate determinant in melanoma.

J Exp Clin Cancer Res 2019 Jan 14;38(1):17. Epub 2019 Jan 14.

School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong, 21 Sassoon Road, Hong Kong, China.

Background: In this research, we aimed to resolve contradictory results whether SOX9 plays a positive or negative role in melanoma progression and determine whether SOX9 and its closely related member SOX10 share the same or distinct targets in mediating their functions in melanoma.

Methods: Immunofluorescence, TCGA database and qPCR were used to analyze the correlation between the expression patterns and levels of SOX9, SOX10 and NEDD9 in melanoma patient samples. AlamarBlue, transwell invasion and colony formation assays in melanoma cell lines were conducted to investigate the epistatic relationship between SOX10 and NEDD9, as well as the effects of graded SOX9 expression levels. Read More

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https://jeccr.biomedcentral.com/articles/10.1186/s13046-018-
Publisher Site
http://dx.doi.org/10.1186/s13046-018-0998-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6330758PMC
January 2019
17 Reads

Trimodally treatment for stage IIIa NSCLC patients increases survival while not effecting surgical mortality or complexity.

J Cardiothorac Surg 2019 Jan 9;14(1). Epub 2019 Jan 9.

Department of Cardiothoracic Surgery, Rabin Medical Center, Beilinson Campus, Petach-Tikva, Israel.

Introduction: Advanced non-small cell lung cancer (NSCLC) is still a therapeutic challenge as the 5-year survival is under 30%. The optimal treatment regimen is still under debate.

Hypothesis: Neo adjuvant (NA) treatment given pre-pneumonectomy does not increase surgical complexity or peri-OP mortality while it has a potential to increase long term survival. Read More

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http://dx.doi.org/10.1186/s13019-018-0829-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6327573PMC
January 2019
1 Read

Population-based validation of the National Comprehensive Cancer Network recommendations for baseline imaging for bladder cancer: a case for routine baseline bone scan?

J Comp Eff Res 2019 Feb 9;8(3):157-163. Epub 2019 Jan 9.

Clinical Oncology Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt.

Aim: This study aims at evaluating the performance of some of the imaging recommendations of the National Comprehensive Cancer Network (NCCN) for initial evaluation of bladder cancer.

Methods: Surveillance, epidemiology and end results program (2010-2015) was queried and patients with clinically (T1-T4) bladder cancer and complete information about clinical T/N (tumor/nodal) stage and metastatic sites were extracted. The following characteristics were evaluated in the current analysis: sensitivity, specificity, number needed to investigate (NNI), positive predictive value (PPV), negative predictive value and accuracy. Read More

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https://www.futuremedicine.com/doi/10.2217/cer-2018-0113
Publisher Site
http://dx.doi.org/10.2217/cer-2018-0113DOI Listing
February 2019
8 Reads

Parotid incidentalomas on positron emission tomography: what is their clinical significance?

Nucl Med Commun 2019 Mar;40(3):264-269

Norwich Radiology Academy, The Cotman Centre, Norwich.

Objective And Aim: The increased use of PET/CT in cancer staging has resulted in more incidental findings in unexpected locations, making this a challenge for the radiologist interpreting the study. Our aim was to determine the frequency of parotid incidentalomas and to assess the ability of PET/CT to characterize them.

Patients And Methods: At the Norfolk and Norwich University Trust, in between October 2010 to October 2015, 4044 patients had a PET/CT examination. Read More

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http://dx.doi.org/10.1097/MNM.0000000000000961DOI Listing
March 2019
2 Reads

Prognostic Value and Clinical Impact of Pretreatment FDG PET in Pulmonary Lymphoepithelioma-Like Carcinoma.

Clin Nucl Med 2019 Feb;44(2):e68-e75

Thoracic Medicine, and.

Purpose: Compared with other forms of non-small cell lung cancer, pulmonary lymphoepithelioma-like carcinoma (LELC) is rarer and portends better outcomes. We sought to investigate the prognostic role and clinical impact of pretreatment F-FDG PET in pulmonary LELC.

Methods: A total of 71 patients with pulmonary LELC were identified through a retrospective review of clinical records. Read More

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http://dx.doi.org/10.1097/RLU.0000000000002371DOI Listing
February 2019
3 Reads

PET-CT has low specificity for mediastinal staging of non-small-cell lung cancer in an endemic area for tuberculosis: a diagnostic test study (LACOG 0114).

BMC Cancer 2019 Jan 3;19(1). Epub 2019 Jan 3.

Medical School, Pontifical Catholic University of Rio Grande do Sul, Porto Alegre, Brazil.

Background: The present study aims to assess the performance of 18F-FDG PET-CT on mediastinal staging of non-small cell lung cancer (NSCLC) in a location with endemic granulomatous infectious disease.

Methods: Diagnostic test study including patients aged 18 years or older with operable stage I-III NSCLC and indication for a mediastinal lymph node biopsy. All patients underwent a 18F-FDG PET-scan before invasive mediastinal staging, either through mediastinoscopy or thoracotomy, which was considered the gold-standard. Read More

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https://bmccancer.biomedcentral.com/articles/10.1186/s12885-
Publisher Site
http://dx.doi.org/10.1186/s12885-018-5233-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6318867PMC
January 2019
2 Reads

Whole-Body Staging of Metastatic Atypical Meningioma Using 68Ga-DOTATATE PET/CT.

Clin Nucl Med 2019 Mar;44(3):227-228

Radiology.

A 43-year-old woman with suspected recurrence of atypical meningioma World Health Organization grade II presented extensive intracranial lesions with high Ga-DOTATATE uptake. Moreover, numerous Ga-DOTATATE-positive bone, lung, and liver lesions were seen. For final diagnosis, biopsies taken from a lung lesion revealed distant metastases of the atypical meningioma. Read More

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http://dx.doi.org/10.1097/RLU.0000000000002422DOI Listing
March 2019
3 Reads

Systematic and combined endosonographic staging of lung cancer (SCORE study).

Eur Respir J 2019 Feb 7;53(2). Epub 2019 Feb 7.

Dept of Respiratory Medicine, Amsterdam University Medical Center, University of Amsterdam, Amsterdam, The Netherlands.

Guidelines recommend endosonography for mediastinal nodal staging in patients with resectable nonsmall cell lung cancer (NSCLC). We hypothesise that a systematic endobronchial ultrasound (EBUS) evaluation combined with an oesophageal investigation using the same EBUS bronchoscope (EUS-B) improves mediastinal nodal staging the current practice of targeted positron emission tomography (PET)-computed tomography (CT)-guided EBUS staging alone.A prospective, multicentre, international study (NCT02014324) was conducted in consecutive patients with (suspected) resectable NSCLC. Read More

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http://dx.doi.org/10.1183/13993003.00800-2018DOI Listing
February 2019
10 Reads

Successful treatment with temozolomide in an elderly woman with advanced pulmonary large-cell neuroendocrine carcinoma: A case report.

Medicine (Baltimore) 2018 Dec;97(51):e13318

Department of Medical Oncology.

Rationale: Pulmonary large-cell neuroendocrine carcinoma (LCNEC) is a rare type of lung cancer, and 40% of patients are in stage IV at initial diagnosis. It has an extremely poor prognosis with a 1-year survival rate of 27%. Patients with LCNEC are predominantly male, older, and heavy smokers. Read More

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http://Insights.ovid.com/crossref?an=00005792-201812210-0001
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http://dx.doi.org/10.1097/MD.0000000000013318DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6320007PMC
December 2018
3 Reads

Nivolumab therapy for lung cancer with tracheo-parenchymal fistula: A case report.

Medicine (Baltimore) 2018 Dec;97(50):e13739

Department of Molecular and Internal Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University, Minami-ku.

Rationale: Tracheobronchial fistulas are rare complications in lung cancer patients. These lesions are associated with a high rate of mortality caused by infection and bleeding, and there is no consensus on a definitive optimal therapy.

Patient Concerns And Diagnoses: The patient was a 59-year-old man with a right lung mass showing mediastinal invasion and tracheal compression, diagnosed with adenocarcinoma, cT4N0M0, stage IIIA. Read More

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http://dx.doi.org/10.1097/MD.0000000000013739DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6320206PMC
December 2018
1 Read

Optimal Endobronchial Ultrasound Strain Elastography Assessment Strategy: An Explorative Study.

Respiration 2018 Dec 14;97(4):337-347. Epub 2018 Dec 14.

Department of Pulmonology, Radboud University Medical Center, Nijmegen, The Netherlands,

Background: In lung cancer staging, mediastinal lymph nodes are currently aspirated using endobronchial ultrasound transbronchial needle aspiration (EBUS-TBNA) based on size and FDG-PET avidity. EBUS strain elastography (SE) is a new technique that may help predict the presence of malignancy. However, a standardized assessment strategy for EBUS-SE measurement is lacking. Read More

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http://dx.doi.org/10.1159/000494143DOI Listing
December 2018
1 Read

Adoption of prophylactic cranial irradiation (PCI) for extensive stage small cell lung cancer (ES-SCLC): a population based outcome study.

Radiat Oncol 2018 Dec 14;13(1):247. Epub 2018 Dec 14.

Division of Radiation Oncology, National Cancer Center Singapore, Singapore, Singapore.

Background: The survival benefit of PCI in ES-SCLC reported by a European randomized trial (RCT) in 2007 was not replicated by a Japanese RCT published in 2017. This study aimed to evaluate the uptake of PCI before and after publication of the European RCT and its association with survival in ES-SCLC.

Methods: We identified eligible patients in the only two Singapore national cancer centres from 2003 to 2010. Read More

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https://ro-journal.biomedcentral.com/articles/10.1186/s13014
Publisher Site
http://dx.doi.org/10.1186/s13014-018-1184-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6295074PMC
December 2018
7 Reads

[A Case Report : FDG Uptake to Brown Adipose Tissue Activated by Elevated Serum Catecholamine in a Patient with Pheochromocytoma].

Hinyokika Kiyo 2018 Nov;64(11):435-438

The Department of Urology, Osaka National Hospital.

A 69-year-old woman was admitted to the previous hospital because of a right adrenal tumor detected by a medical checkup. Although the tumor was diagnosed as non-functional adrenal adenoma, abdominal computed tomography (CT) revealed a left renal mass which was suspected to be renal cell carcinoma. Chest CT seeking for metastatic lesions revealed lung cancer of the left lung. Read More

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http://dx.doi.org/10.14989/ActaUrolJap_64_11_435DOI Listing
November 2018
2 Reads

[The predictive role of PET/CT imaging in clinical N and M staging and treatment decision process. Institutional experiences in Hungary].

Orv Hetil 2018 Sep;159(39):1593-1601

Egészségügyi Központ, Diagnosztikai és Onkoradiológiai Intézet, Kaposvári Egyetem Kaposvár, Szent Imre u. 14/B, 7400.

Introduction And Aim: The aim of our study was to investigate changes in clinical staging N (lymph node) and M (distant metastasis) in patients who receive PET/CT-based 3D radiotherapy within complex oncological treatment, and compare to conventional cross-sectional imaging staging technique. We also investigated the presence of PET/CT-detected second tumors and the effect of PET/CT on therapeutic decisions.

Method: From the 1st of January 2015 to the 30th of November 2016, 192 patients (n = 192) were treated with PET/CT-based radiation (109 head, 44 lung, 28 rectum and 11 cervical localization) in the Oncoradiology Institute of the Health Center of the University of Kaposvár. Read More

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https://www.akademiai.com/doi/10.1556/650.2018.31207
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http://dx.doi.org/10.1556/650.2018.31207DOI Listing
September 2018
6 Reads

Development of a radiomics nomogram based on the 2D and 3D CT features to predict the survival of non-small cell lung cancer patients.

Eur Radiol 2019 May 6;29(5):2196-2206. Epub 2018 Dec 6.

Key Laboratory of Molecular Imaging, Chinese Academy of Science, Beijing, 100080, China.

Objectives: The aim of this study was to develop a radiomics nomogram by combining the optimized radiomics signatures extracted from 2D and/or 3D CT images and clinical predictors to assess the overall survival of patients with non-small cell lung cancer (NSCLC).

Methods: One training cohort of 239 and two validation datasets of 80 and 52 NSCLC patients were enrolled in this study. Nine hundred seventy-five radiomics features were extracted from each patient's 2D and 3D CT images. Read More

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http://dx.doi.org/10.1007/s00330-018-5770-yDOI Listing

[18F-FDG PET/CT features on paraganglioma of testis with multiple lymph node and lung metastasis: A case report and literature review].

Zhong Nan Da Xue Xue Bao Yi Xue Ban 2018 Oct;43(10):1164-1168

PET/CT Center, Second Xiangya Hospital, Central South University, Changsha 410011, China.

Objective: To determine the clinicopathological and imaging features in 18F-fluoro-2-deoxyglucose (18F-FDG) positron emission tomography and computed tomography (PET/CT) for paraganglioma of testis, and to increase the diagnostic accuracy.
 Methods: A case of paraganglioma of testis with multiple lymph node and lung metastasis were reported. PET/CT and pathological findings in the case were retrospectively analyzed. Read More

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http://dx.doi.org/10.11817/j.issn.1672-7347.2018.10.019DOI Listing
October 2018
2 Reads

Preoperative brain MRI for clinical stage IA lung cancer: is routine scanning rational?

J Cancer Res Clin Oncol 2019 Feb 7;145(2):503-509. Epub 2018 Dec 7.

Department of Thoracic Surgery, Fudan University Shanghai Cancer Center, 270 Dong-An Road, Shanghai, 200032, China.

Purpose: Early detection and control of lung cancer brain metastases (BMs) are important. However, several guideline recommendations are inconsistent with regard to routine preoperative brain MRI, especially in patients with clinical stage IA lung cancer. Our study evaluated the value of preoperative brain MRI in patients with clinical stage IA lung cancer. Read More

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http://link.springer.com/10.1007/s00432-018-2814-2
Publisher Site
http://dx.doi.org/10.1007/s00432-018-2814-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6373267PMC
February 2019
14 Reads

Effect of Tumor Location and Dosimetric Predictors for Chest Wall Toxicity in Single-Fraction Stereotactic Body Radiation Therapy for Stage I Non-Small Cell Lung Cancer.

Pract Radiat Oncol 2019 Mar 7;9(2):e187-e195. Epub 2018 Dec 7.

Department of Radiation Oncology, Cleveland Clinic, Cleveland, Ohio.

Purpose: Dosimetric parameters to limit chest wall toxicity (CWT) are not well defined in single-fraction (SF) stereotactic body radiation therapy (SBRT) phase 2 trials. We sought to determine the relationship of tumor location and dosimetric parameters with CWT for SF-SBRT.

Methods And Materials: From a prospective registry of 1462 patients, we identified patients treated with 30 Gy or 34 Gy. Read More

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http://dx.doi.org/10.1016/j.prro.2018.11.011DOI Listing
March 2019
3 Reads