7,411 results match your criteria Imaging in Lung Cancer Staging


Computed DWI MRI Results in Superior Capability for N-Stage Assessment of Non-Small Cell Lung Cancer Than That of Actual DWI, STIR Imaging, and FDG-PET/CT.

J Magn Reson Imaging 2022 Jun 26. Epub 2022 Jun 26.

Department of Radiology, Fujita Health University School of Medicine, Toyoake, Japan.

Background: Computed diffusion-weighted imaging (cDWI) is a mathematical computation technique that generates DWIs for any b-value by using actual DWI (aDWI) data with at least two different b-values and may improve differentiation of metastatic from nonmetastatic lymph nodes.

Purpose: To determine the appropriate b-value for cDWI to achieve a better diagnostic capability for lymph node staging (N-staging) in non-small cell lung cancer (NSCLC) patients compared to aDWI, short inversion time (TI) inversion recovery (STIR) imaging, or positron emission tomography with 2-[fluorine-18] fluoro-2-deoxy-d-glucose combined with computed tomography (FDG-PET/CT).

Study Type: Prospective. Read More

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New PET Tracers: Current Knowledge and Perspectives in Lung Cancer.

Semin Nucl Med 2022 Jun 22. Epub 2022 Jun 22.

Department of Clinical Physiology and Nuclear Medicine, Rigshospitalet Copehagen University Hospital, Copenhagen, Denmark.

PET/CT with the tracer 2-[F]fluoro-2-deoxy-D-glucose ([F]FDG) has improved diagnostic imaging in cancer and is routinely used for diagnosing, staging and treatment planning in lung cancer patients. However, pitfalls of [F]FDG-PET/CT limit the use in specific settings. Additionally, lung cancer is still the leading cause of cancer associated death and has high risk of recurrence after curative treatment. Read More

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FDG PET/CT for Primary Staging of Lung Cancer and Mesothelioma.

Semin Nucl Med 2022 Jun 20. Epub 2022 Jun 20.

Department of Radiology, Duke University, Durham, NC; Department of Medicine, Otago Medical School, University of Otago, Dunedin, New Zealand. Electronic address:

Lung cancer is the leading cause of cancer-related mortality in the United States. Accurate staging at initial diagnosis determines appropriate treatment and is the most important predictor of survival. Since 2018, the 8th edition of the TNM staging system has been used to stage lung cancer based on local tumor extent (T), nodal involvement (N), and metastases (M). Read More

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PET/MR Imaging of a Lung Metastasis Model of Clear Cell Renal Cell Carcinoma with (2S,4R)-4-[F]Fluoroglutamine.

Mol Imaging Biol 2022 Jun 22. Epub 2022 Jun 22.

Department of Urology, MD Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX, 77030, USA.

Purpose: Metabolic reprogramming plays an important role in the tumorigenesis of clear cell renal cell carcinoma (ccRCC). Currently, positron emission tomography (PET) reporters are not used clinically to visualize altered glutamine metabolism in ccRCC, which greatly hinders detection, staging, and real-time therapeutic assessment. We sought to determine if (2S,4R)-4-[F]fluoroglutamine ([F]FGln) could be used to interrogate altered glutamine metabolism in ccRCC lesions in the lung. Read More

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Diagnosis and treatment of Merkel cell carcinoma: European consensus-based interdisciplinary guideline - Update 2022.

Eur J Cancer 2022 Jun 19;171:203-231. Epub 2022 Jun 19.

Universite' de Paris, INSERM U976, AP-HP, Dermatology Department, Saint Louis Hospital, Paris, France. Electronic address:

Merkel cell carcinoma (MCC) is a rare skin cancer, accounting for less than 1% of all cutaneous malignancies. It is found predominantly in white populations and risk factors include advanced age, ultraviolet exposure, male sex, immunosuppression, such as AIDS/HIV infection, haematological malignancies or solid organ transplantation, and Merkel cell polyomavirus infection. MCC is an aggressive tumour with 26% of cases presenting lymph node involvement at diagnosis and 8% with distant metastases. Read More

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Endosonography and endosonography guided needle aspiration for left adrenal gland assessment in lung cancer patients - 10 years' experience.

Adv Respir Med 2022 ;90(3):157-163

Endoscopy Unit, Pulmonary Hospital, Zakopane, Poland.

Introduction: Lung cancer patients (LCP) require invasive evaluation of left adrenal glands (LAG) if distant metastases (M1b/1c) are suspected in CT or PET-CT. Only few studies showed utility of endosonography and particularly EUS-b-FNA as minimally invasive endoscopic method of LAG analysis.

Material And Methods: A retrospective study of consecutive LCP was conducted in two pulmonology centers between January 2010 and December 2019. Read More

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Incidental irradiation of the regional lymph nodes during deep inspiration breath-hold radiation therapy in left-sided breast cancer patients: a dosimetric analysis.

BMC Cancer 2022 Jun 21;22(1):682. Epub 2022 Jun 21.

Department of Radiation Oncology, University Hospital of Freiburg, Robert-Koch-Strasse 3, 79106, Freiburg, Germany.

Background: Radiotherapy using the deep inspiration breath-hold (DIBH) technique compared with free breathing (FB) can achieve substantial reduction of heart and lung doses in left-sided breast cancer cases. The anatomical organ movement in deep inspiration also cause unintended exposure of locoregional lymph nodes to the irradiation field.

Methods: From 2017-2020, 148 patients with left-sided breast cancer underwent breast conserving surgery (BCS) or mastectomy (ME) with axillary lymph node staging, followed by adjuvant irradiation in DIBH technique. Read More

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Clinical quality indicators of pathways to oncological lung surgery.

N Z Med J 2022 Jun 10;135(1556):11-22. Epub 2022 Jun 10.

Cardiothoracic Surgery Registrar, Department of Cardiothoracic Surgery, Dunedin Public Hospital, Dunedin, Otago.

Aims: Multidisciplinary team (MDT) meetings are a standard of care for lung cancer management in many regions around the world. Clinical quality indicators (CQIs) can be used to assess the proficiency of these multidisciplinary teams and compare their performance against those recommended by local and international guidelines. The effectiveness of the lung cancer MDT meeting at Dunedin Public Hospital has been evaluated using CQIs with a focus on the timeliness of surgical management. Read More

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[F]FDG-PET/CT radiomics and artificial intelligence in lung cancer: Technical aspects and potential clinical applications.

Semin Nucl Med 2022 Jun 15. Epub 2022 Jun 15.

Division of Molecular Imaging and Theranostics, Department of Nuclear Medicine, University Hospital Salzburg, Paracelsus Medical University, Salzburg, Austria. Electronic address:

Lung cancer is the second most common cancer and the leading cause of cancer-related death worldwide. Molecular imaging using [F]fluorodeoxyglucose Positron Emission Tomography and/or Computed Tomography ([F]FDG-PET/CT) plays an essential role in the diagnosis, evaluation of response to treatment, and prediction of outcomes. The images are evaluated using qualitative and conventional quantitative indices. Read More

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A Novel Radiopathological Grading System to Tailor Recurrence Risk for Pathologic Stage IA Lung Adenocarcinoma.

Semin Thorac Cardiovasc Surg 2022 Jun 13. Epub 2022 Jun 13.

Guangdong Lung Cancer Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China; Guangdong Provincial Key Laboratory of Translational Medicine in Lung Cancer, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China; Shantou University Medical College, Shantou, China; The Second School of Clinical Medicine, Southern Medical University, Guangzhou, China. Electronic address:

To validate the efficiency of pathological grading system in pathological stage IA lung adenocarcinoma (LUAD), and explore whether integrating preoperative radiological features would enhance the performance of recurrence discrimination. We retrospectively collected 510 patients with resected stage IA LUAD between January 2012 and December 2019 from Guangdong Provincial People's Hospital (GDPH). Pathological grade classification of each case was based on the International Association for the Study of Lung Cancer (IASLC) pathological staging system. Read More

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Contribution of Metabolic Tumor Volume and Total Lesion Glycolysis to Predict Prognosis in Early-Stage Lung Cancer at Preoperative Staging.

J Coll Physicians Surg Pak 2022 Jun;32(6):740-745

Department of Thoracic Surgery, Recep Tayyip Erdogan University Education and Research Hospital, Rize, Turkey.

Objective: To evaluate the effect of metabolic tumor volume (MTV) and total lesion glycolysis (TLG) values of the primary tumor measured by preoperative positron emission tomography/computed tomography (FDG-PET/CT) on survival in patients with operated non-small cell lung cancer (NSCLC).

Study Design: Cohort study.

Place And Duration Of Study: Recep Tayyip Erdogan University, Faculty of Medicine, Department of Medical Oncology from January 2017 to June 2020, Turkey. Read More

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PET-CT in Clinical Adult Oncology: II. Primary Thoracic and Breast Malignancies.

Cancers (Basel) 2022 May 29;14(11). Epub 2022 May 29.

Department of Radiology and Imaging Sciences, University of Utah, Salt Lake City, UT 84132, USA.

Positron emission tomography combined with x-ray computed tomography (PET-CT) is an advanced imaging modality with oncologic applications that include staging, therapy assessment, restaging, and surveillance. This six-part series of review articles provides practical information to providers and imaging professionals regarding the best use of PET-CT for the more common adult malignancies. The second article of this series addresses primary thoracic malignancy and breast cancer. Read More

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[Lung Cancer Surgery for Severe COPD with Emphysema: Tumor Resection with Improvement of Lung Function].

Praxis (Bern 1994) 2022 ;111(8):457-462

Klinik für Thoraxchirurgie, Universitätsspital Zürich, Zürich, Schweiz.

Lung Cancer Surgery for Severe COPD with Emphysema: Tumor Resection with Improvement of Lung Function The golden standard for the therapy of early stage non-small cell lung cancer consists of surgical resection, usually performed as lobectomy or segmentectomy. These procedures demand a certain operability, including certain lung functional reserves. Patients with COPD and emphysema usually have lung function values far below that. Read More

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EGFR Mutation Status and Subtypes Predicted by CT-Based 3D Radiomic Features in Lung Adenocarcinoma.

Onco Targets Ther 2022 30;15:597-608. Epub 2022 May 30.

Department of Radiology, Peking University Shenzhen Hospital, Shenzhen PKU-HKUST Medical Center, Shenzhen, People's Republic of China.

Objective: In this study, we aim to establish a non-invasive tool to predict epidermal growth factor receptor (EGFR) mutation status and subtypes based on radiomic features of computed tomography (CT).

Methods: A total of 233 lung adenocarcinoma patients were investigated and randomly divided into the training and test cohorts. In this study, 2300 radiomic features were extracted from original and filtered (Exponential, Laplacian of Gaussian, Logarithm, Gabor, Wavelet) CT images. Read More

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Toward Improved Outcomes for Patients With Lung Cancer Globally: The Essential Role of Radiology and Nuclear Medicine.

JCO Glob Oncol 2022 05;8:e2100100

Division of Human Health, Department of Nuclear Sciences and Applications, International Atomic Energy Agency, Vienna, Austria.

Purpose: Key to achieving better population-based outcomes for patients with lung cancer is the improvement of medical imaging and nuclear medicine infrastructure globally. This paper aims to outline why and spark relevant health systems strengthening.

Methods: The paper synthesizes the global lung cancer landscape, imaging referral guidelines (including resource-stratified ones), the reliance of TNM staging upon imaging, relevant multinational health technology assessments, and precisely how treatment selection and in turn patient outcomes hinge upon imaging findings. Read More

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Added Value of Respiratory Gating in Positron Emission Tomography for the Clinical Management of Lung Cancer Patients.

Semin Nucl Med 2022 May 25. Epub 2022 May 25.

Department of Radiology, Leiden University Medical Center, Leiden, The Netherlands.

Positron emission tomography (PET) is an important imaging modality for personalizing clinical management of patients with lung cancer. In this regard, PET imaging is essential for adequate clinical staging and monitoring of treatment response in patients with lung cancer. The key advantage of PET over other radiological imaging modalities is its high sensitivity for the detection of pulmonary lesions, normal-sized metastatic hilar and/or mediastinal lymph nodes, and distant metastases. Read More

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FDG PET/CT for Evaluation of Immunotherapy Response in Lung Cancer Patients.

Semin Nucl Med 2022 May 27. Epub 2022 May 27.

Department of Radiology and Nuclear Medicine, Centre Hospitalier de l'Université de Montréal, Montréal, Canada; Centre de recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM), Université de Montréal, Montréal, Québec, Canada; University of Ottawa Heart Institute, Ottawa, Canada. Electronic address:

Over the last decade, several strategies have revolutionized the clinical management of patients with lung cancer, including immunotherapy. Indeed, immune checkpoint inhibitors (ICI) monotherapy or in combination represent the standard-of-care for patients with advanced disease with no actionable mutation. Due to the unique action of ICI to potentiate the immune system, conventional response assessment criteria in medical imaging, such as RECIST 1. Read More

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The value of the Standardized Uptake Value (SUV) and Metabolic Tumor Volume (MTV) in lung cancer.

Authors:
Rodney J Hicks

Semin Nucl Med 2022 May 24. Epub 2022 May 24.

Department of Medicine, St Vincent's Medical School, University of Melbourne, Melbourne Academic Centre for Health, University of Melbourne Centre for Cancer Research, Victorian Comprehensive Cancer Centre, Central Clinical School, Alfred Hospital, Monash University, Melbourne VIC, Australia. Electronic address:

The diagnosis, staging and therapeutic monitoring of lung cancer were amongst the first applications for which the utility of FDG PET was documented and FDG PET/CT is now a routine diagnostic tool for clinical decision-making. As well as having high sensitivity for detection of disease sites, which provides critical information about stage, the intensity of uptake provides deeper biological characterization, while the burden of disease also has potential clinical significance. These disease characteristics can easily be quantified on delayed whole-body imaging as the maximum standardized uptake value (SUV) and metabolic tumor volume (MTV), respectively. Read More

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Extraskeletal Ewing Sarcoma from Head to Toe: Multimodality Imaging Review.

Radiographics 2022 May 27:210226. Epub 2022 May 27.

From the Department of Abdominal Imaging, The University of Texas MD Anderson Cancer Center, 1400 Pressler St, Houston, TX 77030 (A.W., M.B., B.R.K., K.M.E.); Department of Radiology, Mayo Clinic, Jacksonville, Fla (M.D., C.W.B.); Department of Radiology, The University of Texas Health Science Center at Houston, Tex (J.G.); Department of Radiology, University of Wisconsin School of Medicine and Public Health, Madison, Wis (P.J.P., M.G.L.); Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, Mo (V.M.M.); and Department of Laboratory Medicine and Pathology, Mayo Clinic, Scottsdale, Ariz (L.C.).

Extraskeletal Ewing sarcoma (EES) is a rare subtype in the Ewing sarcoma family of tumors (ESFT), which also includes Ewing sarcoma of bone (ESB) and, more recently, primitive neuroectodermal tumors. Although these tumors often have different manifestations, they are grouped on the basis of common genetic translocation and diagnosis from specific molecular and immunohistochemical features. While the large majority of ESFT cases occur in children and in bones, approximately 25% originate outside the skeleton as EES. Read More

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Spatial metabolomics for evaluating response to neoadjuvant therapy in non-small cell lung cancer patients.

Cancer Commun (Lond) 2022 06 20;42(6):517-535. Epub 2022 May 20.

Research Unit Analytical Pathology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, 85764, Germany.

Background: The response to neoadjuvant chemotherapy (NAC) differs substantially among individual patients with non-small cell lung cancer (NSCLC). Major pathological response (MPR) is a histomorphological read-out used to assess treatment response and prognosis in patients NSCLC after NAC. Although spatial metabolomics is a promising tool for evaluating metabolic phenotypes, it has not yet been utilized to assess therapy responses in patients with NSCLC. Read More

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Impact of Bayesian penalized likelihood reconstruction on quantitative and qualitative aspects for pulmonary nodule detection in digital 2-[F]FDG-PET/CT.

Sci Rep 2022 May 18;12(1):8308. Epub 2022 May 18.

Department of Nuclear Medicine, University Hospital Zurich, Rämistrasse 100, 8091, Zurich, Switzerland.

To evaluate the impact of block sequential regularized expectation maximization (BSREM) reconstruction on quantitative and qualitative aspects of 2-[F]FDG-avid pulmonary nodules compared to conventional ordered subset expectation maximization (OSEM) reconstruction method. Ninety-one patients with 144 2-[F]FDG-avid pulmonary nodules (all ≤ 20 mm) undergoing PET/CT for oncological (re-)staging were retrospectively included. Quantitative parameters in BSREM and OSEM (including point spread function modelling) were measured, including maximum standardized uptake value (SUV). Read More

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Relationships between SUVmax of lung adenocarcinoma and different T stages, histological grades and pathological subtypes: a retrospective cohort study in China.

BMJ Open 2022 05 17;12(5):e056804. Epub 2022 May 17.

Department of Nuclear Medicine, Shanghai Chest Hospital, Shanghai Jiao Tong University, Shanghai, China

Objectives: Cancer cell has aberrant metabolism. The purpose of this study aimed to investigate relationships between maximum standard uptake value (SUVmax)of fluoro-2-deoxy-d-glucose and T stages, histological grades and pathological subtypes of lung adenocarcinoma.

Design: Retrospective cohort study, employing the Kruskal-Wallis, Bonferroni-Dunn and Mann-Whitney tests to compare SUVmax of different T stages, histological grades and pathological subtypes of lung adenocarcinoma. Read More

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Prognostic value of thoracic tumor staging and volume parameters in non-small cell lung cancer patients with synchronous solitary bone metastasis.

J Thorac Dis 2022 Apr;14(4):1130-1138

Department of Orthopedic Oncology, Changzheng Hospital, Naval Medical University, Shanghai, China.

Background: Non-small cell lung cancer (NSCLC) patients with synchronous solitary metastasis are a heterogeneous population. The analysis and evaluation of NSCLC patients with synchronous solitary bone metastases by cTN stage (thoracic tumor staging) and volume parameters have not yet been studied. The purpose of this study is to estimate the prognostic value of cTN stage and volume parameters obtained by fluorodeoxyglucose (FDG) positron emission tomography (PET)/computed tomography (CT) in NSCLC patients with synchronous solitary bone metastasis. Read More

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Lung Cancer: Diagnosis, Treatment Principles, and Screening.

Am Fam Physician 2022 May;105(5):487-494

Loma Linda University School of Medicine, Loma Linda, CA, USA.

Lung cancer is the second most common cancer in men and women in the United States; however, it remains the leading cause of cancer-related death in the United States and worldwide. The most common but nonspecific symptom of lung cancer is cough. Associated symptoms, including hemoptysis or shortness of breath, or systemic symptoms, including anorexia or weight loss, greatly increase the likelihood of having lung cancer. Read More

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Higher accuracy of [ Ga]Ga-DOTA-FAPI-04 PET/CT comparing with 2-[F]FDG PET/CT in clinical staging of NSCLC.

Eur J Nucl Med Mol Imaging 2022 Jul 11;49(8):2983-2993. Epub 2022 May 11.

Key Laboratory of Carcinogenesis and Translational Research, (Ministry of Education/Beijing), NMPA Key Laboratory for Research and Evaluation of Radiopharmaceuticals (National Medical Products Administration), Department of Nuclear Medicine, Peking University Cancer Hospital & Institute, No. 52 Fucheng Rd, Beijing, 100142, China.

Purpose: This study aimed to explore the clinical staging performance of [ Ga]Ga-DOTA-FAPI-04 PET/CT compared with that of 2-[F]FDG PET/CT in non-small cell lung cancer (NSCLC) patients lesion by lesion.

Methods: A total of 134 diagnosed or suspected NSCLC patients were enrolled in the prospective study (ChiCTR2000038080); they received paired 2-[F]FDG PET/CT and [ Ga]Ga-DOTA-FAPI-04 PET/CT. Of these patients, the retrospective analysis of 74 NSCLC patients with pathological results was conducted from primary tumor (T) diagnosis, lymph node (N), and metastatic lesion (M) staging. Read More

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Revisiting Indications for Brain Imaging During the Clinical Staging Evaluation of Lung Cancer.

JTO Clin Res Rep 2022 May 6;3(5):100318. Epub 2022 Apr 6.

Division of Thoracic Surgery, Department of Surgery, Yale University School of Medicine, New Haven, Connecticut.

Introduction: Available guidelines are inconsistent as to whether patients with newly diagnosed clinical stage II NSCLC should receive routine brain imaging.

Methods: The National Cancer Database was queried for the prevalence of isolated brain metastases among patients with newly diagnosed NSCLC in 2016 and 2017. Patients with metastases in locations other than the brain were excluded. Read More

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Computed tomography perfusion (CTP) in primary lung cancer: Results from a tertiary care centre.

Lung India 2022 May-Jun;39(3):220-229

Department of Diagnostic and Interventional Radiology, All India Institute of Medical Sciences, Jodhpur, Rajasthan, India.

Context: Lung cancer is the leading cause of cancer-related deaths in the world. Computed tomography perfusion (CTP) parameters can be used to evaluate the vascular flow dynamics of lung tumours. We set out to evaluate the CTP parameters in lung cancer and correlate them with histopathological subtype and other characteristics of patients with Lung Cancer. Read More

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Quantifying lung cancer heterogeneity using novel CT features: a cross-institute study.

Insights Imaging 2022 Apr 28;13(1):82. Epub 2022 Apr 28.

Department of Epidemiology and Biostatistics, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences / School of Basic Medicine, Peking Union Medical College, Beijing, China.

Background: Radiomics-based image metrics are not used in the clinic despite the rapidly growing literature. We selected eight promising radiomic features and validated their value in decoding lung cancer heterogeneity.

Methods: CT images of 236 lung cancer patients were obtained from three different institutes, whereupon radiomic features were extracted according to a standardized procedure. Read More

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Angiogenesis versus Metabolic Imaging in Locally Advanced Breast Cancer Patients - A Comparative Study.

Indian J Nucl Med 2022 Jan-Mar;37(1):54-60. Epub 2022 Mar 25.

Department of Nuclear Medicine, Post Graduate Institute of Medical Education and Research, Chandigarh, India.

Purpose: The comparison of angiogenesis imaging (Ga-68-DOTA-Arginine-Glycine-Aspartic Acid [RGD]) positron emission tomography/computed tomography [PET/CT]) with metabolic imaging (F-18 fluorodeoxyglucose [FDG] PET/CT) in primary staging and response assessment to neoadjuvant chemotherapy (NACT) in locally advanced breast cancer (LABC) patients.

Methods: In this prospective study, 85 female patients with LABC were subjected to two PET/CT studies (Ga-68-DOTA-RGD and F-18 FDG) within 1 week of each other. Thirty patients had repeat studies 4 weeks after completing eight cycles of NACT. Read More

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Increased use of diagnostic CT imaging increases the detection of stage IA lung cancer: pathways and patient characteristics.

BMC Cancer 2022 Apr 27;22(1):464. Epub 2022 Apr 27.

The Danish Clinical Quality Program and Clinical Registries (RKKP), Aarhus, Denmark.

Background: At Silkeborg Regional Hospital, Denmark, the number of stage IA lung cancer increased after implementation of increased use of CT investigations and a corresponding reduction in chest X-ray. The aim of the present study was to understand the changes in referral pathways, patient characteristics and imaging procedures behind the observed increase in early-stage lung cancer.

Methods: The referral and imaging pathways for all patients diagnosed with lung cancer in 2013-2018 were described based on manually curated information from the electronic health care systems and staging information from the Danish Lung Cancer Registry. Read More

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