6,086 results match your criteria Imaging in Lung Cancer Staging


Lung cancer imaging methods in China from 2005 to 2014: A national, multicenter study.

Thorac Cancer 2019 Feb 8. Epub 2019 Feb 8.

Department of Diagnostic Radiology, National Cancer Center/ National Clinical Research Center for Cancer/ Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

Background: The study was conducted to examine changes in diagnostic and staging imaging methods for lung cancer in China over a 10-year period and to determine the relationships between such changes and socioeconomic development.

Methods: This was a hospital-based, nationwide, multicenter retrospective study of primary lung cancer cases. The data were extracted from the 10-year primary lung cancer databases at eight tertiary hospitals from various geographic areas in China. Read More

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http://doi.wiley.com/10.1111/1759-7714.12988
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http://dx.doi.org/10.1111/1759-7714.12988DOI Listing
February 2019
7 Reads

Bone marrow biopsy in the initial staging of Ewing sarcoma: Experience from a single institution.

Pediatr Blood Cancer 2019 Feb 5:e27653. Epub 2019 Feb 5.

Chemotherapy Section, IRCCS-Rizzoli Orthopaedic Institute, Bologna, Italy.

Background: Ewing sarcoma (ES) is the second most common bone tumor in adolescents and children. Staging workup for ES includes imaging and bone marrow biopsy (BMB). The effective role of BMB is now under discussion. Read More

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http://dx.doi.org/10.1002/pbc.27653DOI Listing
February 2019
2.562 Impact Factor

Population-based assessment of the national comprehensive cancer network recommendations for baseline imaging of hepatocellular carcinoma.

Med Oncol 2019 Feb 1;36(3):26. Epub 2019 Feb 1.

Department of Oncology, University of Calgary, Tom Baker Cancer Centre, 1331 29 ST NW, Calgary, AB, T2N 4N2, Canada.

This analysis aims to evaluate the performance characteristics of alternative baseline imaging thresholds in a cohort of hepatocellular carcinoma (HCC) patients from the Surveillance, Epidemiology, and End Results (SEER) database. HCC patients within the SEER database (2010-2015) who had complete information on clinical T and N stages as well as complete information on metastatic sites were eligible for the current study. Various performance characteristics associated with baseline imaging were investigated, including specificity, sensitivity, positive likelihood ratio (LR), negative LR, number needed to investigate (NNI), negative predictive value (NPV), positive predictive value (PPV), and accuracy. Read More

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http://dx.doi.org/10.1007/s12032-019-1248-2DOI Listing
February 2019

M1b Disease in the 8th Edition of TNM Staging of Lung Cancer: Pattern of Single Extrathoracic Metastasis and Clinical Outcome.

Oncologist 2019 Jan 29. Epub 2019 Jan 29.

Department of Radiology, Brigham and Women's Hospital and Dana-Farber Cancer Institute, Boston, Massachusetts, USA

Background: The 8th edition of TNM staging of non-small cell lung cancer (NSCLC) has revised M classification and defined M1b disease with single extrathoracic metastasis, which is distinguished from M1c with multiple extrathoracic metastases. We investigated the prevalence, characteristics, and overall survival (OS) of M1b disease in patients with stage IV NSCLC.

Methods: The study reviewed the medical records and imaging studies of 567 patients with stage IV NSCLC to determine M stage using the 8th edition of TNM staging. Read More

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http://dx.doi.org/10.1634/theoncologist.2018-0596DOI Listing
January 2019

Lung and Pancreatic Tumor Characterization in the Deep Learning Era: Novel Supervised and Unsupervised Learning Approaches.

IEEE Trans Med Imaging 2019 Jan 23. Epub 2019 Jan 23.

Risk stratification (characterization) of tumors from radiology images can be more accurate and faster with computeraided diagnosis (CAD) tools. Tumor characterization through such tools can also enable non-invasive cancer staging, prognosis, and foster personalized treatment planning as a part of precision medicine. In this study, we propose both supervised and unsupervised machine learning strategies to improve tumor characterization. Read More

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http://dx.doi.org/10.1109/TMI.2019.2894349DOI Listing
January 2019
1 Read

Resected Pure Small Cell Lung Carcinomas and Combined Small Cell Lung Carcinomas: Histopathology Features, Imaging Features, and Prognoses.

AJR Am J Roentgenol 2019 Jan 23:1-9. Epub 2019 Jan 23.

3 Department of Thoracic Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.

Objective: The objective of our study was to investigate histopathology features, imaging features, and prognoses of surgically resected pure small cell lung carcinomas (SCLCs) and combined SCLCs.

Materials And Methods: Forty-one patients with a pure SCLC or a combined SCLC underwent preoperative chest CT and F-FDG PET/CT and subsequent surgical resection. The clinicopathologic findings were noted by reviewing the electronic medical records. Read More

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http://dx.doi.org/10.2214/AJR.18.20519DOI Listing
January 2019
2 Reads

Impact of different image reconstructions on PET quantification in non-small cell lung cancer: a comparison of adenocarcinoma and squamous cell carcinoma.

Br J Radiol 2019 Jan 23:20180792. Epub 2019 Jan 23.

1 Department of Nuclear Medicine, University Hospital Zurich , Zurich , Switzerland.

Objective:: Positron emission tomography (PET) using 18F-fluordeoxyglucose (F-FDG) is an established imaging modality for tumor staging in patients with non-small cell lung cancer (NSCLC). There is a growing interest in using F-FDG PET for therapy response assessment in NSCLC which relies on quantitative PET parameters such as standardized uptake values (SUV). Different reconstruction algorithms in PET may affect SUV. Read More

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http://dx.doi.org/10.1259/bjr.20180792DOI Listing
January 2019
1 Read

Left systematic mediastinal lymph node dissection.

Multimed Man Cardiothorac Surg 2019 01 2;2019. Epub 2019 Jan 2.

General Surgery Department General Hospital of Athens "Evangelismos'' Athens, Greece.

Sampling, or systematic mediastinal lymph node dissection, is the standard-of-care surgical treatment for early stage non-small cell lung cancer, according to guidelines from the European Society of Thoracic Surgeons. Lymph node status defines disease status and patients' prognosis. In this  video tutorial, a radical ipsilateral mediastinal lymph node dissection in a man suffering from a left, centrally located lung adenocarcinoma is presented. Read More

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http://dx.doi.org/10.1510/mmcts.2019.001DOI Listing
January 2019

Population-based validation of the National Comprehensive Cancer Network recommendations for baseline imaging for bladder cancer: a case for routine baseline bone scan?

J Comp Eff Res 2019 Feb 9;8(3):157-163. Epub 2019 Jan 9.

Clinical Oncology Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt.

Aim: This study aims at evaluating the performance of some of the imaging recommendations of the National Comprehensive Cancer Network (NCCN) for initial evaluation of bladder cancer.

Methods: Surveillance, epidemiology and end results program (2010-2015) was queried and patients with clinically (T1-T4) bladder cancer and complete information about clinical T/N (tumor/nodal) stage and metastatic sites were extracted. The following characteristics were evaluated in the current analysis: sensitivity, specificity, number needed to investigate (NNI), positive predictive value (PPV), negative predictive value and accuracy. Read More

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https://www.futuremedicine.com/doi/10.2217/cer-2018-0113
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http://dx.doi.org/10.2217/cer-2018-0113DOI Listing
February 2019
4 Reads

Prognostic Value and Clinical Impact of Pretreatment FDG PET in Pulmonary Lymphoepithelioma-Like Carcinoma.

Clin Nucl Med 2019 Feb;44(2):e68-e75

Thoracic Medicine, and.

Purpose: Compared with other forms of non-small cell lung cancer, pulmonary lymphoepithelioma-like carcinoma (LELC) is rarer and portends better outcomes. We sought to investigate the prognostic role and clinical impact of pretreatment F-FDG PET in pulmonary LELC.

Methods: A total of 71 patients with pulmonary LELC were identified through a retrospective review of clinical records. Read More

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http://dx.doi.org/10.1097/RLU.0000000000002371DOI Listing
February 2019
2 Reads

Systematic and combined endosonographic staging of lung cancer (SCORE study).

Eur Respir J 2019 Feb 7;53(2). Epub 2019 Feb 7.

Dept of Respiratory Medicine, Amsterdam University Medical Center, University of Amsterdam, Amsterdam, The Netherlands.

Guidelines recommend endosonography for mediastinal nodal staging in patients with resectable nonsmall cell lung cancer (NSCLC). We hypothesise that a systematic endobronchial ultrasound (EBUS) evaluation combined with an oesophageal investigation using the same EBUS bronchoscope (EUS-B) improves mediastinal nodal staging the current practice of targeted positron emission tomography (PET)-computed tomography (CT)-guided EBUS staging alone.A prospective, multicentre, international study (NCT02014324) was conducted in consecutive patients with (suspected) resectable NSCLC. Read More

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http://dx.doi.org/10.1183/13993003.00800-2018DOI Listing
February 2019
1 Read

Successful treatment with temozolomide in an elderly woman with advanced pulmonary large-cell neuroendocrine carcinoma: A case report.

Medicine (Baltimore) 2018 Dec;97(51):e13318

Department of Medical Oncology.

Rationale: Pulmonary large-cell neuroendocrine carcinoma (LCNEC) is a rare type of lung cancer, and 40% of patients are in stage IV at initial diagnosis. It has an extremely poor prognosis with a 1-year survival rate of 27%. Patients with LCNEC are predominantly male, older, and heavy smokers. Read More

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http://Insights.ovid.com/crossref?an=00005792-201812210-0001
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http://dx.doi.org/10.1097/MD.0000000000013318DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6320007PMC
December 2018
2 Reads

Nivolumab therapy for lung cancer with tracheo-parenchymal fistula: A case report.

Medicine (Baltimore) 2018 Dec;97(50):e13739

Department of Molecular and Internal Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University, Minami-ku.

Rationale: Tracheobronchial fistulas are rare complications in lung cancer patients. These lesions are associated with a high rate of mortality caused by infection and bleeding, and there is no consensus on a definitive optimal therapy.

Patient Concerns And Diagnoses: The patient was a 59-year-old man with a right lung mass showing mediastinal invasion and tracheal compression, diagnosed with adenocarcinoma, cT4N0M0, stage IIIA. Read More

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http://dx.doi.org/10.1097/MD.0000000000013739DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6320206PMC
December 2018

Optimal Endobronchial Ultrasound Strain Elastography Assessment Strategy: An Explorative Study.

Respiration 2018 Dec 14:1-11. Epub 2018 Dec 14.

Department of Pulmonology, Radboud University Medical Center, Nijmegen, The

Background: In lung cancer staging, mediastinal lymph nodes are currently aspirated using endobronchial ultrasound transbronchial needle aspiration (EBUS-TBNA) based on size and FDG-PET avidity. EBUS strain elastography (SE) is a new technique that may help predict the presence of malignancy. However, a standardized assessment strategy for EBUS-SE measurement is lacking. Read More

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http://dx.doi.org/10.1159/000494143DOI Listing
December 2018
1 Read

Adoption of prophylactic cranial irradiation (PCI) for extensive stage small cell lung cancer (ES-SCLC): a population based outcome study.

Radiat Oncol 2018 Dec 14;13(1):247. Epub 2018 Dec 14.

Division of Radiation Oncology, National Cancer Center Singapore, Singapore, Singapore.

Background: The survival benefit of PCI in ES-SCLC reported by a European randomized trial (RCT) in 2007 was not replicated by a Japanese RCT published in 2017. This study aimed to evaluate the uptake of PCI before and after publication of the European RCT and its association with survival in ES-SCLC.

Methods: We identified eligible patients in the only two Singapore national cancer centres from 2003 to 2010. Read More

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https://ro-journal.biomedcentral.com/articles/10.1186/s13014
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http://dx.doi.org/10.1186/s13014-018-1184-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6295074PMC
December 2018
5 Reads

[A Case Report : FDG Uptake to Brown Adipose Tissue Activated by Elevated Serum Catecholamine in a Patient with Pheochromocytoma].

Hinyokika Kiyo 2018 Nov;64(11):435-438

The Department of Urology, Osaka National Hospital.

A 69-year-old woman was admitted to the previous hospital because of a right adrenal tumor detected by a medical checkup. Although the tumor was diagnosed as non-functional adrenal adenoma, abdominal computed tomography (CT) revealed a left renal mass which was suspected to be renal cell carcinoma. Chest CT seeking for metastatic lesions revealed lung cancer of the left lung. Read More

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http://dx.doi.org/10.14989/ActaUrolJap_64_11_435DOI Listing
November 2018

[The predictive role of PET/CT imaging in clinical N and M staging and treatment decision process. Institutional experiences in Hungary].

Orv Hetil 2018 Sep;159(39):1593-1601

Egészségügyi Központ, Diagnosztikai és Onkoradiológiai Intézet, Kaposvári Egyetem Kaposvár, Szent Imre u. 14/B, 7400.

Introduction And Aim: The aim of our study was to investigate changes in clinical staging N (lymph node) and M (distant metastasis) in patients who receive PET/CT-based 3D radiotherapy within complex oncological treatment, and compare to conventional cross-sectional imaging staging technique. We also investigated the presence of PET/CT-detected second tumors and the effect of PET/CT on therapeutic decisions.

Method: From the 1st of January 2015 to the 30th of November 2016, 192 patients (n = 192) were treated with PET/CT-based radiation (109 head, 44 lung, 28 rectum and 11 cervical localization) in the Oncoradiology Institute of the Health Center of the University of Kaposvár. Read More

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https://www.akademiai.com/doi/10.1556/650.2018.31207
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http://dx.doi.org/10.1556/650.2018.31207DOI Listing
September 2018
3 Reads

Development of a radiomics nomogram based on the 2D and 3D CT features to predict the survival of non-small cell lung cancer patients.

Eur Radiol 2018 Dec 6. Epub 2018 Dec 6.

Key Laboratory of Molecular Imaging, Chinese Academy of Science, Beijing, 100080, China.

Objectives: The aim of this study was to develop a radiomics nomogram by combining the optimized radiomics signatures extracted from 2D and/or 3D CT images and clinical predictors to assess the overall survival of patients with non-small cell lung cancer (NSCLC).

Methods: One training cohort of 239 and two validation datasets of 80 and 52 NSCLC patients were enrolled in this study. Nine hundred seventy-five radiomics features were extracted from each patient's 2D and 3D CT images. Read More

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http://dx.doi.org/10.1007/s00330-018-5770-yDOI Listing
December 2018

[18F-FDG PET/CT features on paraganglioma of testis with multiple lymph node and lung metastasis: A case report and literature review].

Zhong Nan Da Xue Xue Bao Yi Xue Ban 2018 Oct;43(10):1164-1168

PET/CT Center, Second Xiangya Hospital, Central South University, Changsha 410011, China.

Objective: To determine the clinicopathological and imaging features in 18F-fluoro-2-deoxyglucose (18F-FDG) positron emission tomography and computed tomography (PET/CT) for paraganglioma of testis, and to increase the diagnostic accuracy.
 Methods: A case of paraganglioma of testis with multiple lymph node and lung metastasis were reported. PET/CT and pathological findings in the case were retrospectively analyzed. Read More

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http://dx.doi.org/10.11817/j.issn.1672-7347.2018.10.019DOI Listing
October 2018
1 Read

Localization of the Metastatic Site Within a Lymph Node Using Endobronchial Elastography.

Semin Thorac Cardiovasc Surg 2018 Dec 7. Epub 2018 Dec 7.

Department of General Thoracic Surgery, Chiba University Graduate School of Medicine, Chiba, Chiba, Japan.

Endobronchial elastography is a novel imaging technology which visualizes the relative stiffness of the targeted tissue. Endobronchial elastography can be used for differentiating malignant and benign lymph nodes during nodal staging in patients with lung cancer. Another possible utility of endobronchial elastography would be targeting high-risk area within the intrathoracic lymph node. Read More

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http://dx.doi.org/10.1053/j.semtcvs.2018.11.013DOI Listing
December 2018
1 Read

Towards More Structure: Comparing TNM Staging Completeness and Processing Time of Text-Based Reports versus Fully Segmented and Annotated PET/CT Data of Non-Small-Cell Lung Cancer.

Contrast Media Mol Imaging 2018 1;2018:5693058. Epub 2018 Nov 1.

University Hospital Basel, University of Basel, Department of Radiology, Petersgraben 4, 4031 Basel, Switzerland.

Results of PET/CT examinations are communicated as text-based reports which are frequently not fully structured. Incomplete or missing staging information can be a significant source of staging and treatment errors. We compared standard text-based reports to a manual full 3D-segmentation-based approach with respect to TNM completeness and processing time. Read More

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http://dx.doi.org/10.1155/2018/5693058DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6236664PMC
November 2018
1 Read

Whole-Body MRI: Comparison of Its Capability for TNM Staging of Malignant Pleural Mesothelioma With That of Coregistered PET/MRI, Integrated FDG PET/CT, and Conventional Imaging.

AJR Am J Roentgenol 2019 Feb 4;212(2):311-319. Epub 2018 Dec 4.

1 Department of Radiology, Division of Functional and Diagnostic Imaging Research, Kobe University Graduate School of Medicine, 7-5-2 Kusunoki-cho, Chuo-ku, Kobe 650-0017, Japan.

Objective: The purpose of this study was to compare the diagnostic accuracy of whole-body MRI, coregistered FDG PET/MRI, integrated FDG PET/CT, and conventional imaging examination including bone scintigraphy, contrast-enhanced brain MRI, and CT for malignant pleural mesothelioma (MPM) staging according to the new International Association for the Study of Lung Cancer (IASLC) system.

Subjects And Methods: The study subjects were 23 consecutively registered patients with MPM (15 men, eight women; mean age, 68 years for both sexes) who had prospectively undergone whole-body FDG PET/CT, whole-body MRI, conventional radiologic examination, surgical or conventional treatments, pathologic examination, and follow-up conventional imaging examinations between January 2011 and December 2017. TNM staging was evaluated by two independent readers. Read More

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https://www.ajronline.org/doi/10.2214/AJR.18.20111
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http://dx.doi.org/10.2214/AJR.18.20111DOI Listing
February 2019
5 Reads

Convolutional Neural Networks Promising in Lung Cancer T-Parameter Assessment on Baseline FDG-PET/CT.

Contrast Media Mol Imaging 2018 30;2018:1382309. Epub 2018 Oct 30.

Department of Biomedical Sciences, Humanitas University, Milan, Pieve Emanuele, Italy.

Aim: To develop an algorithm, based on convolutional neural network (CNN), for the classification of lung cancer lesions as T1-T2 or T3-T4 on staging fluorodeoxyglucose positron emission tomography (FDG-PET)/CT images.

Methods: We retrospectively selected a cohort of 472 patients (divided in the training, validation, and test sets) submitted to staging FDG-PET/CT within 60 days before biopsy or surgery. TNM system seventh edition was used as reference. Read More

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http://dx.doi.org/10.1155/2018/1382309DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6232785PMC
October 2018

Effectiveness of 18F-FDG PET/CT in the diagnosis, staging and recurrence monitoring of Ewing sarcoma family of tumors: A meta-analysis of 23 studies.

Medicine (Baltimore) 2018 Nov;97(48):e13457

Department of Orthopaedics, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, Shandong, China.

Background: To investigate the value of positron emission tomography (PET) and PET/computed tomography (CT) using fluorine-18-fluorodeoxyglucose (F-FDG) in the diagnosis, staging, restaging and recurrence monitoring of Ewing sarcoma family of tumors (ESFTs), a meta-analysis was performed through systematically searching PubMed, Embase, and Cochrane Central library to retrieve articles.

Methods: After screening and diluting out the articles that met inclusion criteria to be used for statistical analysis the pooled evaluation indexes including sensitivity, specificity, and diagnostic odd ratio (DOR) as well as the summary receiver operating characteristic curve (SROC) were calculated involving diagnostic data (true positive, false positive, false negative, and true negative) extracted from original studies.

Results: Screening determined that out of 2007, 23 studies involving a total of 524 patients were deemed viable for inclusion in the meta-analysis. Read More

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http://dx.doi.org/10.1097/MD.0000000000013457DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6283220PMC
November 2018
5.723 Impact Factor

Lymph node resection induces the activation of tumor cells in the lungs.

Cancer Sci 2019 Feb 17;110(2):509-518. Epub 2019 Jan 17.

Laboratory of Biomedical Engineering for Cancer, Graduate School of Biomedical Engineering, Tohoku University, Sendai, Japan.

Lymph node (LN) dissection is a crucial procedure for cancer staging, diagnosis and treatment, and for predicting patient survival. Activation of lung metastatic lesions after LN dissection has been described for head and neck cancer and breast cancer. Preclinical studies have reported that dissection of a tumor-bearing LN is involved in the activation and rapid growth of latent tumor metastases in distant organs, but it is also important to understand how normal (non-tumor-bearing) LN resection influences secondary cancer formation. Read More

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http://dx.doi.org/10.1111/cas.13898DOI Listing
February 2019
1 Read

Initial extended resection or neoadjuvant therapy for T4 non-small cell lung cancer-What is the evidence?

Shanghai Chest 2018 Oct 11;2. Epub 2018 Oct 11.

Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

Locally advanced non-small cell lung cancer (NSCLC) tumors that invade surrounding structures within the chest (T4) are a heterogeneous group, and, as such, there are no straightforward guidelines for their management. Advances in imaging, invasive mediastinal staging, and neoadjuvant therapies have expanded the role of surgery with curative intent for this patient group and have also diminished the rate of explorative thoracotomies. Unlike for T4 superior sulcus tumors, the use of neoadjuvant therapy for central T4 tumors is not clearly defined. Read More

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http://dx.doi.org/10.21037/shc.2018.09.08DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6258022PMC
October 2018

Utility Of Molecular Imaging With 2-Deoxy-2-[Fluorine-18] Fluoro-D-Glucose Positron Emission Tomography (18f-Fdg Pet) For Small Cell Lung Cancer (Sclc): A Radiation Oncology Perspective.

Curr Radiopharm 2018 Nov 20. Epub 2018 Nov 20.

Department of Radiation Oncology; University of Health Sciences, Gulhane Medical Faculty, Ankara. Turkey.

Background And Objective: Although accounting for a relatively small proportion of all lung cancers, small cell lung cancer (SCLC) remains to be a global health concern with grim prognosis. Radiotherapy (RT) plays a central role in SCLC management either as a curative or palliative therapeutic strategy. There has been considerable progress in RT of SCLC thanks to improved imaging techniques leading to accurate target localization for precise delivery of RT. Read More

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http://dx.doi.org/10.2174/1874471012666181120162434DOI Listing
November 2018
8 Reads

Metastatic thymic carcinoid responds to chemoradiation and octreotide: A case report.

Medicine (Baltimore) 2018 Nov;97(47):e13286

Department of Oncology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.

Rationale: Thymic carcinoids are a rare type of malignant neuroendocrine tumors which have a poor prognosis due to their distant metastasis, invasive behaviour, and postoperative recurrence. Surgical resection is still the fundamental mode for treating thymic carcinoids. Here, we report the rapid shrinkage of an atypical thymic carcinoid with multiple metastases following chemoradiation plus octreotide as a first-line therapy PATIENT CONCERNS:: A 39-year-old Chinese man presented with chest tightness, dyspnea with a history of lumbago and untreated malignant thymoma. Read More

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http://dx.doi.org/10.1097/MD.0000000000013286DOI Listing
November 2018
11 Reads

Role of Low-Dose Computerized Tomography in Lung Cancer Screening among Never-Smokers.

J Thorac Oncol 2018 Nov 13. Epub 2018 Nov 13.

Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea; Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Seoul National University Bundang Hospital, Bundang-Gu, Seongnam, Gyeonggi-do, Republic of Korea. Electronic address:

Introduction: The incidence of lung cancer among never-smokers has been increasing rapidly. The U. S. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S15560864183341
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http://dx.doi.org/10.1016/j.jtho.2018.11.002DOI Listing
November 2018
13 Reads

Prognostic impact of combining whole-body PET/CT and brain PET/MR in patients with lung adenocarcinoma and brain metastases.

Eur J Nucl Med Mol Imaging 2019 02 10;46(2):467-477. Epub 2018 Nov 10.

Department of Nuclear Medicine and Center for Advanced Molecular Imaging and Translation, Chang Gung Memorial Hospital and Chang Gung University, 5 Fu-Shin Street, Kueishan, Taoyuan, 333, Taiwan.

Purpose: The role of brain FDG-PET in patients with lung cancer and brain metastases remains unclear. Here, we sought to determine the prognostic significance of whole-body PET/CT plus brain PET/MR in predicting the time to neurological progression (nTTP) and overall survival (OS) in this patient group.

Methods: Of 802 patients with non-small cell lung cancer who underwent primary staging by a single-day protocol of whole-body PET/CT plus brain PET/MR, 72 cases with adenocarcinoma and brain metastases were enrolled for a prognostic analysis of OS. Read More

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http://link.springer.com/10.1007/s00259-018-4210-1
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http://dx.doi.org/10.1007/s00259-018-4210-1DOI Listing
February 2019
8 Reads

68Ga-PSMA PET/CT in prostate cancer patients - patterns of disease, benign findings and pitfalls.

Cancer Imaging 2018 Nov 1;18(1):39. Epub 2018 Nov 1.

Department of Medical Biophysics and Nuclear Medicine, Hadassah University Hospital, Ein Kerem, Jerusalem, Israel.

Background: 68Ga-PSMA PET/CT has an important role in assessment of prostate cancer patients with biochemical recurrence and is evolving in staging high- and intermediate risk disease. The aim of present study was to describe the metastatic patterns and frequency of involved sites of prostate cancer and to assess the incidence of benign Ga68-PSMA avid PET/CT findings in a large patient population.

Methods: 68Ga-PSMA PET/CT studies performed in two tertiary medical centers over a period of 24 months were retrospectively reviewed. Read More

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https://cancerimagingjournal.biomedcentral.com/articles/10.1
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http://dx.doi.org/10.1186/s40644-018-0175-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6211573PMC
November 2018
2 Reads

[A Case of Stage IV Rectal Cancer Achieving Long-Term Stable Disease Treated with Chemotherapy and Residual Tumor Resection].

Gan To Kagaku Ryoho 2018 Oct;45(10):1527-1529

Dept. of Surgery, Tokyo Women's Medical University Medical Center East.

We herein report a Stage IV case ofrectal cancer in a patient who achieved stable disease and was treated monthly with fluorouracil(FU)monotherapy plus bevacizumab(Bmab)against relapse after residual tumor resection and withdrawal because ofref usal to continue chemotherapy, even though a marked response was obtained with standard chemotherapy. A 73-year-old woman visited a former hospital in 2014, and was diagnosed with rectal cancer with liver and lung metastases (diagnosed with Rb, T3, M1b[liver, lung]cStage IV). Chemotherapy(mFOLFOX6 plus Bmab)was initiated with a consideration of conversion. Read More

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October 2018
2 Reads

Performance of F-FDG PET/MRI and F-FDG PET/CT for T and N staging in patients with non-small-cell lung cancer.

Eur J Nucl Med Mol Imaging 2019 02 30;46(2):522-523. Epub 2018 Oct 30.

CHU de Bordeaux, F-33000, Bordeaux, France.

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http://dx.doi.org/10.1007/s00259-018-4201-2DOI Listing
February 2019
1 Read

Predictive factors for adrenal metastasis in extra-adrenal malignancy patients with solitary adrenal mass.

J Surg Oncol 2018 Dec 27;118(8):1271-1276. Epub 2018 Oct 27.

Department of Urology, School of Medicine, Kyungpook National University, Daegu, Korea.

Background And Objectives: The adrenal gland is a frequent site for metastasis, and a solitary adrenal mass is often observed during staging workup or imaging follow-up in patients with extra-adrenal malignancy. To create an appropriate management plan, it is essential to distinguish between benign adrenal lesions and metastasis in patients with extra-adrenal cancer having solitary adrenal masses. Therefore, here we evaluated the predictive factors for adrenal metastasis in patients with extra-adrenal malignancy having solitary adrenal mass. Read More

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http://doi.wiley.com/10.1002/jso.25272
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http://dx.doi.org/10.1002/jso.25272DOI Listing
December 2018
12 Reads

Best practices for the management of thymic epithelial tumors: A position paper by the Italian collaborative group for ThYmic MalignanciEs (TYME).

Cancer Treat Rev 2018 Dec 5;71:76-87. Epub 2018 Oct 5.

Department of Medical Oncology, Humanitas Clinical and Research Hospital, Rozzano (Milan), Italy.

Thymic epithelial tumors (TETs) are a heterogenous group of rare tumors, with a complex histopatological classification. Furthermore, the recent introduction of the first TNM staging system, that is scheduled to replace the Masaoka-Koga system, may create further difficulties in TET management, that remains challenging. Several guidelines for treatment of TETs are available and provide recommendations based mainly on non randomized trials and retrospective or limited series. Read More

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http://dx.doi.org/10.1016/j.ctrv.2018.10.001DOI Listing
December 2018
10 Reads

The combination of EBUS-TBNA and the PAB antibody led to a successful treatment for lung cancer in a patient with asymptomatic sarcoidosis mimicking nodal metastasis.

Respir Med Case Rep 2018 18;25:296-299. Epub 2018 Oct 18.

Department of Pathology, Japanese Red Cross Medical Center, 4-1-22 Hiroo, Shibuya-ku, Tokyo 150-8935, Japan.

Correct staging of lung cancer is important for the selection of the best therapy, but discriminating between lymphadenopathy from lung cancer and from sarcoidosis by imaging examinations is difficult. Additionally, distinguishing lymphadenopathy of sarcoidosis from sarcoid reactions which are sometimes caused by lung cancer is difficult on imaging and pathological findings. A 73-year-old woman was diagnosed as lung cancer clinical T1bN3M0 stage ШB based on false-positive F-fluoro-2-deoxyglucose positron emission tomography uptake. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S22130071183030
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http://dx.doi.org/10.1016/j.rmcr.2018.10.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6198119PMC
October 2018
6 Reads

Population-based validation of the National Cancer Comprehensive Network recommendations for baseline imaging workup of cutaneous melanoma.

Melanoma Res 2019 Feb;29(1):53-58

Department of Clinical Oncology, Faculty of Medicine, Ain Shams University, Cairo, Egypt.

The aim of the current study is to assess the performance of some of the imaging scans recommended in the National Comprehensive Cancer Network Guidelines as part of baseline staging for cutaneous melanoma, regarding the detection of lung, brain, bone, and liver metastases. Surveillance, Epidemiology and End Results database (2010-2015) was used to extract the data, and cases with cutaneous melanoma and complete information about TN stages and sites of distant metastases were explored. Performance parameters assessed in the current study included positive predictive value (PPV), negative predictive value, sensitivity, specificity, number needed to investigate (NNI), and accuracy. Read More

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http://dx.doi.org/10.1097/CMR.0000000000000528DOI Listing
February 2019
5 Reads
2.282 Impact Factor

Resection of primary malignant lung melanoma: a case report.

Asian Cardiovasc Thorac Ann 2018 Nov 25;26(9):710-712. Epub 2018 Oct 25.

Department of Thoracic Surgery, Ohta Nishinouchi Hospital, Koriyama, Fukushima, Japan.

A 74-year-old man presented with chest pain and high-grade fever. Chest radiography revealed a consolidation in the right lower lung lobe, and computed tomography demonstrated atelectasis and infiltration of the right lower lobe, with pleural effusion. Bronchoscopy revealed a tumor occluding the inlet of the lateral/posterior basal segmental bronchus of the right lung, but bronchoscopic biopsy did not lead to a definitive diagnosis. Read More

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http://dx.doi.org/10.1177/0218492318811735DOI Listing
November 2018
11 Reads

Nanomedicines guided nanoimaging probes and nanotherapeutics for early detection of lung cancer and abolishing pulmonary metastasis: Critical appraisal of newer developments and challenges to clinical transition.

J Control Release 2018 Dec 22;292:29-57. Epub 2018 Oct 22.

Department of Pharmaceutics, Faculty of Pharmacy, Universiti Teknologi MARA (UiTM) Selangor, Puncak Alam Campus, 42300 Bandar Puncak Alam, Selangor, Malaysia. Electronic address:

Lung cancer (LC) is the second most prevalent type of cancer and primary cause of mortality among both men and women, worldwide. The most commonly employed diagnostic modalities for LC include chest X-ray (CXR), magnetic-resonance-imaging (MRI), computed tomography (CT-scan), and fused-positron-emitting-tomography-CT (PET-CT). Owing to several limitations associated with the use of conventional diagnostic tools such as radiation burden to the patient, misleading diagnosis ("missed lung cancer"), false staging and low sensitivity and resolution, contemporary diagnostic regimen needed to be employed for screening of LC. Read More

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https://www.sciencedirect.com/journal/journal-of-controlled-
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https://www.sciencedirect.com/journal/journal-of-controlled-
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https://linkinghub.elsevier.com/retrieve/pii/S01683659183060
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http://dx.doi.org/10.1016/j.jconrel.2018.10.024DOI Listing
December 2018
12 Reads
7.705 Impact Factor

Impact of FDG-PET on the Detection of Patients with Lung Cancer at High Risk for ILD.

In Vivo 2018 Nov-Dec;32(6):1457-1462

Translational Lung Research Center Heidelberg, Member of the German Center for Lung Research DZL, Heidelberg, Germany.

Background/aim: Idiopathic pulmonary fibrosis IPF is a type of interstitial lung disease (ILD) with poor prognosis. Lung cancer (LC) is a frequent complication in IPF, where all therapeutic options are potential triggers for acute exacerbation of IPF.

Patients And Methods: Patients with 2-deoxy-2-fluoro-D-glucose-positron emission tomography/computer tomography (FDG-PET/CT) results before lobectomy for LC with and without (n=10 each) signs of ILD in initial imaging and after-care CT were retrospectively analyzed. Read More

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http://iv.iiarjournals.org/lookup/doi/10.21873/invivo.11399
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http://dx.doi.org/10.21873/invivo.11399DOI Listing
January 2019
11 Reads

Lymph Node Size Predicts for Asymptomatic Brain Metastases in Patients With Non-small-cell Lung Cancer at Diagnosis.

Clin Lung Cancer 2019 Jan 24;20(1):e107-e114. Epub 2018 Sep 24.

Department of Radiation Oncology, University of Maryland School of Medicine, Baltimore, MD. Electronic address:

Background: We questioned whether the National Comprehensive Cancer Network recommendations for brain magnetic resonance imaging (MRI) for patients with stage ≥ IB non-small-cell lung cancer (NSCLC) was high-yield compared with American College of Clinical Pharmacy and National Institute for Health and Care Excellence guidelines recommending stage III and above NSCLC. We present the prevalence and factors predictive of asymptomatic brain metastases at diagnosis in patients with NSCLC without extracranial metastases.

Materials And Methods: A retrospective analysis of 193 consecutive, treatment-naïve patients with NSCLC diagnosed between January 2010 and August 2015 was performed. Read More

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http://dx.doi.org/10.1016/j.cllc.2018.09.014DOI Listing
January 2019
4 Reads
3.104 Impact Factor

Pulmonary metastasectomy of colorectal cancer origin: Evaluating process and outcomes.

J Surg Oncol 2018 Dec 17;118(8):1292-1300. Epub 2018 Oct 17.

Department of Colorectal Surgical Oncology, Tata Memorial Centre, Mumbai, Maharashtra, India.

Background: This study was undertaken to evaluate the effect of change in policy of computed tomography (CT) scan of the thorax in staging and follow-up of colorectal cancer (CRC). Another objective was to review the outcomes following pulmonary metastasectomies (Pmets) and to determine the prognostic factors affecting outcomes.

Methods: This is a retrospective analysis from a prospective cohort database of patients, who underwent Pmet for CRC origin from August 2004 to February 2016. Read More

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http://doi.wiley.com/10.1002/jso.25273
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http://dx.doi.org/10.1002/jso.25273DOI Listing
December 2018
197 Reads
3.244 Impact Factor

Accelerated Hypofractionated Radiotherapy Versus Stereotactic Body Radiotherapy for the Treatment of Stage I Nonsmall Cell Lung Cancer-A Single Institution Experience With Long-Term Follow-Up.

Technol Cancer Res Treat 2018 01;17:1533033818806318

1 Division of Radiation Oncology, Department of Radiology, Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital, Bunkyo-ku, Tokyo, Japan.

Purpose: Although stereotactic body radiation therapy is one of the standard treatments for stage I nonsmall cell lung cancer, in the case of central tumors it carries the risk of severe adverse events for serial organs. Accelerated hypofractionated radiotherapy is considered a reasonable alternative to treat central tumors. We have been treating central tumors with accelerated hypofractionated radiotherapy using a 75 Gy/25 fr/5 weeks regimen, and we compared the results with those of stereotactic body radiation therapy using 48 Gy/4 fr/1 week. Read More

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http://dx.doi.org/10.1177/1533033818806318DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6195005PMC
January 2018

[Bronchoscopy and Interventional Pulmonology].

Kyobu Geka 2018 09;71(10):850-857

Department of General Thoracic Surgery, Chiba University Graduate School of Medicine, Chiba, Japan.

Recent advance in bronchology and interventional pulmonology contributes to improve the quality of patient care in thoracic surgery. Narrow band imaging (NBI) combined with high definition bronchoscopy clearly visualize the aberrant tumor vessels on the mucosa of endobronchial malignancy. It helps the preoperative surgical planning for the clear bronchial margin during the surgery. Read More

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September 2018
12 Reads

Advances in Imaging and Automated Quantification of Malignant Pulmonary Diseases: A State-of-the-Art Review.

Lung 2018 Dec 9;196(6):633-642. Epub 2018 Oct 9.

Federal University of Rio de Janeiro, Av. Carlos Chagas Filho, 373, Rio De Janeiro, 21941-902, Brazil.

Quantitative imaging in lung cancer is a rapidly evolving modality in radiology that is changing clinical practice from a qualitative analysis of imaging features to a more dynamic, spatial, and phenotypical characterization of suspected lesions. Some quantitative parameters, such as the use of 18F-FDG PET/CT-derived standard uptake values (SUV), have already been incorporated into current practice as it provides important information for diagnosis, staging, and treatment response of patients with lung cancer. A growing body of evidence is emerging to support the use of quantitative parameters from other modalities. Read More

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http://link.springer.com/10.1007/s00408-018-0156-0
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http://dx.doi.org/10.1007/s00408-018-0156-0DOI Listing
December 2018
11 Reads
2.171 Impact Factor

Are Staging Computed Tomography (CT) Scans of the Chest Necessary in Pancreatic Adenocarcinoma?

Ann Surg Oncol 2018 Dec 1;25(13):3936-3942. Epub 2018 Oct 1.

Department of Surgery, Massachusetts General Hospital, Boston, MA, USA.

Background: There is no consensus on the use of chest imaging in pancreatic ductal adenocarcinoma (PDAC) patients. Among PDAC patients, we examined the use of chest computed tomography (CT) over time and determined whether the use of chest CT led to a survival difference or change in management via identification of indeterminate lung nodules (ILNs).

Methods: Retrospective clinical data was collected for patients diagnosed with PDAC from 1998 to 2014. Read More

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http://dx.doi.org/10.1245/s10434-018-6764-3DOI Listing
December 2018
5 Reads

18F-fluorocholine positron emission tomography-computed tomography (18F-FCH PET/CT) for staging of high-risk prostate cancer patients.

Can Urol Assoc J 2018 Sep 27. Epub 2018 Sep 27.

Department of Nuclear Medicine; Jewish General Hospital, McGill University Health Centre, Montreal, QC, Canada.

Introduction: We sought to evaluate the diagnostic performance of 18F-fluorocholine positron emission tomography-computed tomography (18F-FCH PET/CT) for initial staging of patients with high-risk prostate cancer. Secondary objectives were to compare the value of 18F-FCH PET/CT to conventional imaging modalities and to evaluate its clinical impact.

Methods: We conducted a retrospective study including 76 patients who underwent 18F-FCH PET/CT for initial staging of high-risk prostate cancer. Read More

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http://dx.doi.org/10.5489/cuaj.5142DOI Listing
September 2018
3 Reads

Practice-based evidence for the clinical benefit of PET/CT-results of the first oncologic PET/CT registry in Germany.

Eur J Nucl Med Mol Imaging 2019 01 29;46(1):54-64. Epub 2018 Sep 29.

Institute of Clinical Epidemiology and Applied Biostatistics, Eberhard-Karls-University Tuebingen, Tübingen, Germany.

Purpose: The purpose of this study was to evaluate the impact of PET/CT on clinical management of cancer patients based on a prospective data registry. The study was developed to inform consultations with public health insurances on PET/CT coverage.

Methods: We evaluated a prospective patient cohort having a clinically indicated PET/CT at a single German University Center from April 2013 to August 2016. Read More

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http://dx.doi.org/10.1007/s00259-018-4156-3DOI Listing
January 2019
13 Reads

Usefulness of iodine-123 whole-body scan in planning iodine-131 treatment of the differentiated thyroid carcinoma in children and adolescence.

Nucl Med Commun 2018 Dec;39(12):1121-1128

Department of Imaging, Nuclear Medicine Unit.

Objective: Radioiodine treatment (RAI-T) of differentiated thyroid carcinoma (DTC) is important to avoid disease progression, in particular in pediatric patients. For these reasons, a diagnostic scan may be useful to assess therapeutic tailored activity. The purpose of our study was to evaluate the usefulness of diagnostic whole-body scan (WBS) with iodine-123 (I) in combination with recombinant human thyroid-stimulating hormone (rh-TSH; Thyrogen) (rh-TSH-Dx-WBS), in planning RAI-T or further surgery before RAI-T in pediatric DTC. Read More

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http://dx.doi.org/10.1097/MNM.0000000000000922DOI Listing
December 2018
22 Reads

The role of F-18 FDG PET/CT in differentiating benign from malignant pulmonary masses and accompanying lymph nodes.

Tuberk Toraks 2018 Jun;66(2):130-135

Department of Nuclear Medicine, Faculty of Medicine, Akdeniz University, Antalya, Turkey.

Introduction: The aim of this study was to evaluate the usefulness of SUV and lesion size to differentiate benign and malignant lesions of the lung and accompanying mediastinal lymph node on F-18 FDG PET/CT imaging.

Materials And Methods: A retrospective analysis was carried out on 100 patients with suspected lung cancer who were recommended for PET/CT scans for diagnosis and staging. The results of the SUV, lesion size and patient's age were compared with histopathology which was considered to be the 'gold standard' and sensitivity and specificity were calculated respectively. Read More

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http://www.tuberktoraks.org/linkout.aspx?pmid=30246656
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http://dx.doi.org/10.5578/tt.10809DOI Listing
June 2018
2 Reads