6,992 results match your criteria Imaging in Lung Cancer Staging

T-staging pulmonary oncology from radiological reports using natural language processing: translating into a multi-language setting.

Insights Imaging 2021 Jun 10;12(1):77. Epub 2021 Jun 10.

Department of Radiation Oncology (MAASTRO), GROW School for Oncology and Developmental Biology, Maastricht University Medical Center, Maastricht, The Netherlands.

Background: In the era of datafication, it is important that medical data are accurate and structured for multiple applications. Especially data for oncological staging need to be accurate to stage and treat a patient, as well as population-level surveillance and outcome assessment. To support data extraction from free-text radiological reports, Dutch natural language processing (NLP) algorithm was built to quantify T-stage of pulmonary tumors according to the tumor node metastasis (TNM) classification. Read More

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Advances in multimodal treatment for stage IIIA-N2 non-small cell lung cancer.

J Clin Transl Res 2021 Apr 16;7(2):185-198. Epub 2021 Apr 16.

Department of Radiation Oncology, Hospital Universitario Quirónsalud Madrid, C/Diego de Velázquez, 1, 28223, Pozuelo de Alarcón, Madrid, Spain.

Background And Aim: In Stage IIIA-N2 non-small cell lung cancer (NSCLC), the accuracy of combined positron-emission tomography/computed tomography imaging (PET-CT), together with mediastinal staging techniques, has led to a wide range of challenging clinical scenarios in terms of therapeutic management. Concurrent chemoradiotherapy followed by consolidation immunotherapy remains the standard of care. In patients with potentially-resectable disease, surgery plays an important role in multimodal therapy. Read More

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Oncological Follow-up with 2-[F]-FDG PET/CT in Li-Fraumeni Syndrome

Mol Imaging Radionucl Ther 2021 06;30(2):110-112

Las Américas Clinic Auna, Department of Radiology, Medellin, Antioquia, Colombia

Li-Fraumeni syndrome is a rare disorder caused by abnormalities of the tumor-suppressor protein gene. We present the case of a 26-years-old female diagnosed with bilateral ductal carcinoma. The genetic panel for breast cancer gene 1 (BRCA1) and BRCA2 mutations was negative and positive heterozygous germline tumor protein gene mutations, considering Li-Fraumeni syndrome. Read More

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Importance of chest HRCT in the diagnostic evaluation of fibrosing interstitial lung diseases.

J Bras Pneumol 2021 31;47(3):e20200096. Epub 2021 May 31.

. Departamento de Radiologia, Universidade Federal do Rio de Janeiro, Rio de Janeiro (RJ) Brasil.

Many conditions result in chronic interstitial lung disease (ILD), being classified as fibrosing ILDs, including idiopathic pulmonary fibrosis, connective tissue diseases, sarcoidosis, and fibrotic hypersensitivity pneumonitis. HRCT plays an important role in the clinical evaluation of fibrosing ILDs. Current treatment perspectives are encouraging and reinforce the need for HRCT scans of adequate technical quality for early detection of fibrosing ILD. Read More

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Ga-FAPI-PET/CT in patients with various gynecological malignancies.

Eur J Nucl Med Mol Imaging 2021 May 29. Epub 2021 May 29.

Department of Nuclear Medicine, Heidelberg University Hospital, Heidelberg, Germany.

Purpose: Ga-FAPI (fibroblast activation protein inhibitor) is a novel and highly promising radiotracer for PET/CT imaging. The aim of this retrospective analysis is to explore the potential of FAPI-PET/CT in gynecological malignancies. We assessed biodistribution, tumor uptake, and the influence of pre- or postmenopausal status on tracer accumulation in hormone-sensitive organs. Read More

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Positron Emission Tomography/Computed Tomography Alert Finding in an Esophageal Cancer Patient.

Indian J Nucl Med 2021 Jan-Mar;36(1):80-81. Epub 2021 Mar 4.

Department of Nuclear Medicine, Theageneio Cancer Hospital, Thessaloniki, Greece.

Emergency pathologies often accompany malignancies. We herein report a case of pulmonary abscess in a patient with esophageal cancer which was depicted during the F-18-fluorodeoxyglucose positron emission tomography/computed tomography (PET/CT) staging study. The patient's history of recent dilatation of the cancer stenosis in adjunct to the previous CT lung imaging, which was normal, made evident the diagnosis of the pulmonary abscess due to the perforation of the esophageal neoplasm. Read More

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Development of Brain Metastases in Patients With Non-Small Cell Lung Cancer and No Brain Metastases at Initial Staging Evaluation: Cumulative Incidence and Risk Factor Analysis.

AJR Am J Roentgenol 2021 May 26. Epub 2021 May 26.

Department of Radiology and Research Institute of Radiology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.

While established guidelines give indications for performing staging brain MRI at initial non-small cell lung cancer (NSCLC) diagnosis, guidelines are lacking for performing surveillance brain MRI in patients without brain metastases at presentation. To estimate the cumulative incidence of, and risk factors associated with, brain metastasis development in patients with NSCLC without brain metastases at initial presentation. This retrospective study included 1495 patients with NSCLC (mean age 65±10 years; 920 men, 575 women) without brain metastases at initial evaluation that included brain MRI. Read More

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Analysis of medication-related osteonecrosis of the jaw with bone SPECT/CT: relationship between patient characteristics and maximum standardized uptake value.

Dentomaxillofac Radiol 2021 May 21:20200516. Epub 2021 May 21.

Quantitative Diagnostic Imaging, Field of Oral and Maxillofacial Imaging and Histopathological Diagnostics, Course of Applied Science, The Nippon Dental University Graduate School of Life Dentistry at Niigata, Niigata, Japan.

Objective: To analyze medication-related osteonecrosis of the jaw (MRONJ) with bone single photon emission computed tomography (SPECT)/CT, especially relationship between patient characteristics and maximum standardized uptake value (SUV).

Methods: 48 patients with MRONJ who underwent bone SPECT/CT were prospectively included. MRONJ patients were included 34 osteoporosis and 14 bone metastases from 6 lung cancer, 6 breast cancer and 2 rectal cancer. Read More

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Novel FAP ligands enable improved imaging contrast in sarcoma patients due to FAPI-PET/CT.

Eur J Nucl Med Mol Imaging 2021 May 21. Epub 2021 May 21.

Department of Nuclear Medicine, Heidelberg University Hospital, Heidelberg, Germany.

Purpose: A high expression of fibroblast activation protein (FAP) was observed in multiple sarcomas, indicating an enormous potential for PET/CT using Ga-radiolabeled inhibitors of FAP (FAPI). Therefore, this retrospective study aimed to evaluate the role of the novel hybrid imaging probe for sarcomas as a first clinical evaluation.

Methods: A cohort of 15 patients underwent Ga-FAPI-PET/CT for staging or restaging. Read More

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Concurrent chemoradiotherapy for stage III non-small-cell lung cancer: recent progress and future perspectives (a narrative review).

Transl Lung Cancer Res 2021 Apr;10(4):2018-2031

Department of Oncology and Radiotherapy, Medical University of Gdańsk, Gdańsk, Poland.

Concurrent chemoradiotherapy (CHRT) remains the therapeutic standard for locally advanced inoperable non-small-cell lung cancer (NSCLC). The median overall survival (OS) with this approach is in the range of 20-30 months, with five-year survival of approximately 30%. These outcomes have recently been further improved by supplementing CHRT with maintenance durvalumab, a monoclonal anti-PD-L1 agent. Read More

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Evolving target volume concepts in locally advanced non-small cell lung cancer.

Transl Lung Cancer Res 2021 Apr;10(4):1999-2010

Department of Radiation Oncology (Maastro Clinic), Maastricht University Medical Center+, GROW Research Institute, Maastricht, The Netherlands.

Radiotherapy (RT) target volume concepts for locally advanced lung cancer have been under discussion for years. Although they may be as important as treatment doses, many aspects of them are still based on conventions, which, due to the paucity of prospective data, rely on long-term practice or on clinical knowledge and experience (e.g. Read More

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Pathfinders in oncology from the time the causal relation between tobacco use and lung cancer was established to publication of the first Cancer Staging Manual by the American Joint Committee on Cancer.

Steven I Hajdu

Cancer 2021 May 10. Epub 2021 May 10.

Pathology Consultants, Westlake Village, California.

During the period from 1962 to 1977, several antigens, notably carcinoembryonic antigen and prostate-specific antigen, were discovered and entered clinical use. Ultrasonography, positron emission tomography scanning, and magnetic resonance imaging were introduced, and adjuvant radiation and chemotherapy after limited surgery became routine procedures. Radioimmunoassay and immunohistochemistry techniques were standardized. Read More

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Utility of Prophylactic Cranial Irradiation for Extensive-Stage Small-Cell Lung Cancer in the MRI Screening Era.

Clin Lung Cancer 2021 Mar 26. Epub 2021 Mar 26.

Department of Radiation Oncology, UPMC Hillman Cancer Center, Pittsburgh, PA. Electronic address:

Background: Conflicting data exists regarding the benefit of prophylactic cranial irradiation (PCI) in patients with extensive-stage small-cell lung cancer (ES-SCLC). We sought to retrospectively review outcomes of patients within our network with ES-SCLC treated with and without PCI between 2009 and 2020.

Methods: Endpoints assessed using the Kaplan-Meier estimator were overall survival (OS), freedom from death with uncontrolled intracranial disease (UI-DFS), brain metastasis-free survival (BMFS), and symptomatic BMFS (SBMFS). Read More

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Automated mapping and N-Staging of thoracic lymph nodes in contrast-enhanced CT scans of the chest using a fully convolutional neural network.

Eur J Radiol 2021 Jun 20;139:109718. Epub 2021 Apr 20.

Institute for Diagnostic and Interventional Radiology, University Cologne, Faculty of Medicine and University Hospital Cologne, Kerpener Straße 62, 50937, Cologne, Germany.

Purpose: To develop a deep-learning (DL)-based approach for thoracic lymph node (LN) mapping based on their anatomical location.

Method: The training-and validation-dataset included 89 contrast-enhanced computed tomography (CT) scans of the chest. 4201 LNs were semi-automatically segmented and then assigned to LN levels according to their anatomical location. Read More

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Cutaneous Lesion of the Nose as Initial Presentation of Esophageal Adenocarcinoma.

Anticancer Res 2021 May;41(5):2485-2488

Division of Medical Oncology, Allegheny General Hospital, Pittsburgh, PA, U.S.A.

Background/aim: Cutaneous manifestations of disease are exceedingly rare and commonly overlooked in clinical practice. Allergies or contact dermatitis, autoimmune disease or skin cancer are the most common conditions typically associated with skin lesions. Rarely, cutaneous lesions may be the first sign of internal malignancy, or even resemble recurrent disease in those with history of cancer. Read More

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Ga-FAPI-PET/CT improves diagnostic staging and radiotherapy planning of adenoid cystic carcinomas - Imaging analysis and histological validation.

Radiother Oncol 2021 May 1;160:192-201. Epub 2021 May 1.

Department of Radiation Oncology, Heidelberg University Hospital, Heidelberg, Germany; Heidelberg Institute of Radiation Oncology (HIRO), Heidelberg, Germany.

Background: Adenoid cystic carcinomas (ACCs) are rare epithelial tumors mostly situated in the head and neck region and characterized by infiltrative growth. The tumor stroma of ACCs includes cancer-associated fibroblasts (CAFs) expressing Fibroblast Activation Protein (FAP), a new target for positron emission tomography (PET) imaging. Here we describe the value of PET/ computed tomography (PET/CT) imaging using Ga-labelled FAP-Inhibitors (Ga-FAPI-PET/CT) and their clinical potential for staging and radiotherapy planning in 12 ACC patients (7 primary, 5 recurrent). Read More

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Real-world Israeli single institution experience with PET-PSMA for staging of patients with clinically staged localized prostate carcinoma.

Cancer Rep (Hoboken) 2021 May 2:e1386. Epub 2021 May 2.

Sharett Institute of Oncology, Hadassah-Hebrew University Medical Center, Jerusalem, Israel.

Background: A recent prospective trial, the proPSMA study, showed superior specificity and sensitivity of Positron emission tomography (PET) - Prostate-specific membrane antigen (PSMA) imaging compared standard Computerized tomography (CT) and bone scan for staging of recently diagnosed high-risk local prostate carcinoma for curative intent treatment.

Aim: To share our experience with false-positive PET PSMA scans in newly diagnosed intermediate-risk prostate cancer.

Methods And Results: Here, we report a series of eight patients who underwent systemic staging using PET-PSMA with false-positive results who were ultimately treated with definitive radiation or surgery. Read More

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Ga-68-FAPI as diagnostic tool in sarcoma: Data from the FAPI-PET prospective observational trial.

J Nucl Med 2021 Apr 30. Epub 2021 Apr 30.

Department of Medical Oncology, West-German Cancer Center, University of Duisburg-Essen, Germany.

Bone and soft tissue sarcomas express fibroblast activation protein (FAP) on tumor cells and associated fibroblast. Therefore, FAP is a promising therapeutic and diagnostic target. Novel radio-labelled FAP-Inhibitors (e. Read More

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Prognostic Value of Computed Tomography and/or F-Fluorodeoxyglucose Positron Emission Tomography Radiomics Features in Locally Advanced Non-small Cell Lung Cancer.

Clin Lung Cancer 2021 Mar 27. Epub 2021 Mar 27.

Department of Radiation Oncology, University of California Davis School of Medicine, Sacramento, CA. Electronic address:

Introduction: We investigated whether adding computed tomography (CT) and/or F-fluorodeoxyglucose (F-FDG) PET radiomics features to conventional prognostic factors (CPFs) improves prognostic value in locally advanced non-small cell lung cancer (NSCLC).

Materials And Methods: We retrospectively identified 39 cases with stage III NSCLC who received chemoradiotherapy and underwent planning CT and staging F-FDG PET scans. Seven CPFs were recorded. Read More

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[Malignant mesothelioma of the ovary: a case report].

Pan Afr Med J 2021 27;38:92. Epub 2021 Jan 27.

Service d´Oncologie Médicale, Centre Hospitalier Universitaire (CHU) Hassan II, Fès, Maroc.

Primary malignant mesothelioma of the ovary (PMMO) is an extremely rare tumor which can develop from mesothelial cells. This neoplasia is caused predominantly by exposure to asbestos or other cancer-causing agents. Preoperative assessment, based on computed tomography (CT) scan, magnetic resonance imaging and positron emission tomography, is essential for cancer staging. Read More

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Understanding the patient journey to diagnosis of lung cancer.

BMC Cancer 2021 Apr 14;21(1):402. Epub 2021 Apr 14.

Department of Health Policy and Management, School of Public Health and Tropical Medicine, Tulane University, 1440 Canal Street, Suite 1900, New Orleans, LA, 70112, USA.

Objective: This research describes the clinical pathway and characteristics of two cohorts of patients. The first cohort consists of patients with a confirmed diagnosis of lung cancer while the second consists of patients with a solitary pulmonary nodule (SPN) and no evidence of lung cancer. Linked data from an electronic medical record and the Louisiana Tumor Registry were used in this investigation. Read More

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Computer-Assisted Reporting and Decision Support in Standardized Radiology Reporting for Cancer Imaging.

JCO Clin Cancer Inform 2021 Apr;5:426-434

Harvard Medical School, Boston, MA.

Purpose: Recent advances in structured reporting are providing an opportunity to enhance cancer imaging assessment to drive value-based care and improve patient safety.

Methods: The computer-assisted reporting and decision support (CAR/DS) framework has been developed to enable systematic ingestion of guidelines as clinical decision structured reporting tools embedded within the radiologist's workflow.

Results: CAR/DS tools can reduce the radiology reporting variability and increase compliance with clinical guidelines. Read More

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Prostate Adenocarcinoma with Brain Metastasis: A Surveillance, Epidemiology, and End Results Database Analysis 2010-2015.

Med Sci Monit 2021 Apr 12;27:e930064. Epub 2021 Apr 12.

Department of Internal Medicine, Division of Medical Oncology, University of Kentucky, Lexington, KY, USA.

BACKGROUND Prostate adenocarcinoma rarely metastasize to the brain. The aim of this study was to understand the risk association and survival outcomes comparing prostate cancer with brain metastasis (group 1) with prostate cancer without brain metastasis (group 2) at the time of initial diagnosis. MATERIAL AND METHODS We searched the Surveillance, Epidemiology, and End Results (SEER) statewide cancer registries for all cases of stage IV prostate cancer adenocarcinoma diagnosed between 2010 and 2015. Read More

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Non-small cell lung cancer stage migration as a function of wait times from diagnostic imaging: A pooled analysis from five international centres.

Lung Cancer 2021 05 30;155:136-143. Epub 2021 Mar 30.

Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Australia; Department of Radiation Oncology, Peter MacCallum Cancer Centre, Melbourne, Australia.

Introduction: Patients with non-small cell lung cancer (NSCLC) can experience rapid disease progression between initial staging FDG-PET scans and commencement of curative-intent radiotherapy (RT). Previous studies that estimated stage migration rates by comparing staging PET/CT and treatment-planning PET/CT images were limited by small sample sizes.

Methods: This multicenter, international study combined prospective data from five institutions for PET-staged patients with NSCLC who were intended to receive curative-intent RT. Read More

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Canadian Society of Thoracic Radiology/Canadian Association of Radiologists Clinical Practice Guidance for Non-Vascular Thoracic MRI.

Can Assoc Radiol J 2021 Mar 29:846537121998961. Epub 2021 Mar 29.

Department of Medical Imaging, Sunnybrook Health Sciences Centre, 7938University of Toronto, Toronto, Ontario, Canada.

Historically thoracic MRI has been limited by the lower proton density of lung parenchyma, cardiac and respiratory motion artifacts and long acquisition times. Recent technological advancements in MR hardware systems and improvement in MR pulse sequences have helped overcome these limitations and expand clinical opportunities for non-vascular thoracic MRI. Non-vascular thoracic MRI has been established as a problem-solving imaging modality for characterization of thymic, mediastinal, pleural chest wall and superior sulcus tumors and for detection of endometriosis. Read More

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Cancer Imaging and Patient Care during the COVID-19 Pandemic.

Radiol Imaging Cancer 2020 11 13;2(6):e200058. Epub 2020 Nov 13.

Scientific Editor, RSNA (A.N.B.); Center for Infectious Disease Imaging, NIH Clinical Center, Bethesda, Maryland (D.A.H.); Departments of Pediatrics and Microbiology and Immunology, University of Michigan, Ann Arbor, Michigan (J.B.W.); Division of Cardiothoracic Radiology, Department of Radiology, University of Michigan, Ann Arbor, Michigan (P.A.); Department of Radiology, Division of Abdominal imaging, University of Michigan, Ann Arbor, Michigan (M.M.); Department of Radiology, Biomedical Engineering, and Microbiology and Immunology, University of Michigan, Ann Arbor, Michigan (G.D.L).

Patients with cancer have been negatively impacted during the coronavirus disease 2019 (COVID-19) pandemic, as many of these individuals may be immunosuppressed and of older age. Additionally, cancer follow-up or imaging appointments have been delayed in many clinics around the world. Postponement of routine screening exams will result in delays in new cancer diagnoses. Read More

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November 2020

Interobserver Variability of Quantitative and Qualitative Assessment Using MRI in Malignant Pleural Mesothelioma.

Radiol Cardiothorac Imaging 2020 Apr 30;2(2):e190066. Epub 2020 Apr 30.

Department of Radiology, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Ave, Boston, MA 02215-5491 (R.R.G.); Department of Radiology, St Vincent's University Hospital, Dublin, Ireland (D.J.M.); Magnetic Resonance Research & Development, Siemens Healthineers, Boston, Mass (R.T.S.); Division of Biostatistics, Department of Data Sciences, Dana Farber Cancer Institute, Boston, Mass (E.M.); and Department of Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, Mass (R.B., W.G.R.).

Purpose: To evaluate the interobserver variability associated with quantitative and qualitative MRI assessments of malignant pleural mesothelioma (MPM).

Materials And Methods: Patients with MPM who underwent uniform-protocol preoperative MRI between 2009 and 2014 were included. The MRI-derived tumor volume was estimated. Read More

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Pulmonary carcinomas arising in association with scar: Cytomorphologic features in histologically confirmed cases.

Diagn Cytopathol 2021 Jun 25;49(6):753-760. Epub 2021 Mar 25.

Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA.

Background: Lung carcinoma arising in association with scar tissue is a well-reported but much debated phenomenon. Scar tissue complicates imaging and pathologic tumor measurement for cancer staging. To the best of our knowledge, the cytological findings in lung scar carcinoma (LSC) have not been described in the literature. Read More

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Recurrent feature fusion learning for multi-modality pet-ct tumor segmentation.

Comput Methods Programs Biomed 2021 May 11;203:106043. Epub 2021 Mar 11.

School of Computer Science, University of Sydney, NSW, Australia; Australian Research Council Training Centre for Innovative Bioengineering, NSW, Australia. Electronic address:

Background And Objective: [18f]-fluorodeoxyglucose (fdg) positron emission tomography - computed tomography (pet-ct) is now the preferred imaging modality for staging many cancers. Pet images characterize tumoral glucose metabolism while ct depicts the complementary anatomical localization of the tumor. Automatic tumor segmentation is an important step in image analysis in computer aided diagnosis systems. Read More

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[Initial assessment of lung cancer].

Rev Prat 2020 Dec;70(10):1111-1120

Service d'oncologie thoracique, université Paris-Diderot, hôpital Bichat-Claude-Bernard, AP-HP, Paris, France.

Initial assessment of lung cancer. Lung cancer is frequent with a high mortality rate. Improvement of diagnosis tools provide better staging and tumor characterization enhancing prognosis. Read More

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December 2020