6,632 results match your criteria Imaging in Lung Cancer Staging


Synchronous tumours detected during cancer patient staging: prevalence and patterns of occurrence in multidetector computed tomography.

Pol J Radiol 2020 26;85:e261-e270. Epub 2020 May 26.

Radiology Department, National Cancer Institute Pascale Foundation, Naples, Italy.

Purpose: The incidental detection of one or more additional primary tumours during computed tomography (CT) staging of a patient with known malignancy is rare but possible. This occurrence should be considered by the radiologist when a new lesion is detected, especially if the lesion location is atypical for metastases. The purpose of this report was to document the usefulness of total body CT scan to detect synchronous primary malignancies in cancer patients undergoing a staging workup. Read More

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http://dx.doi.org/10.5114/pjr.2020.95781DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7315052PMC

A review of the role of MRI in diagnosis and treatment of early stage lung cancer.

Clin Transl Radiat Oncol 2020 Sep 6;24:16-22. Epub 2020 Jun 6.

Department of Radiation Oncology, H. Lee Moffitt Cancer Center and Research Institute, 12902 USF Magnolia Dr., Tampa, FL, USA.

Despite magnetic resonance imaging (MRI) being a mainstay in the oncologic care for many disease sites, it has not routinely been used in early lung cancer diagnosis, staging, and treatment. While MRI provides improved soft tissue contrast compared to computed tomography (CT), an advantage in multiple organs, the physical properties of the lungs and mediastinum create unique challenges for lung MRI. Although multi-detector CT remains the gold standard for lung imaging, advances in MRI technology have led to its increased clinical relevance in evaluating early stage lung cancer. Read More

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http://dx.doi.org/10.1016/j.ctro.2020.06.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7306507PMC
September 2020

FDG PET Hybrid Imaging.

Recent Results Cancer Res 2020 ;216:625-667

Department of Nuclear Medicine, University Medicine Rostock, Gertrudenplatz 1, 18057, Rostock, Germany.

Molecular imaging with positron emission tomography (PET) using tumour-seeking radiopharmaceuticals has gained wide acceptance in oncology with many clinical applications. The hybrid imaging modality PET/CT (computed tomography) allows assessing molecular as well as morphologic information at the same time. Therefore, PET/CT represents an efficient tool for whole-body staging and re-staging within one imaging modality. Read More

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http://dx.doi.org/10.1007/978-3-030-42618-7_19DOI Listing
January 2020

Usefulness of Positron Emission Tomography in the Examination of Hilar and Mediastinal Lymphadenopathies in Patients with Suspicion of Lung Cancer.

Can Respir J 2020 5;2020:7909543. Epub 2020 Jun 5.

Escuela de Medicina, Universidad de Santiago de Compostela, Área de Medicina Preventiva y Salud Pública, Santiago de Compostela, Spain.

Introduction: Lung cancer is a major health problem. Mediastinal staging performed with the aid of imaging techniques is essential for appropriate disease treatment and prognosis. Accordingly, this study aimed to ascertain the usefulness of positron emission tomography (PET) in mediastinal staging, establish the best maximum standardized uptake value (SUV) cutoff point, compare its usefulness to that of computed tomography (CT), and determine the influence of histological tumour subtype. Read More

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http://dx.doi.org/10.1155/2020/7909543DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7294363PMC

Imaging features and prognostic value of F-FDG PET/CT detection of soft-tissue metastasis from lung cancer: a retrospective study.

BMC Cancer 2020 Jun 26;20(1):596. Epub 2020 Jun 26.

Department of Nuclear Medicine, the Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, PR China, 646000.

Background: Soft-tissue metastasis (STM) is a relatively rare, but not exceptional, manifestation of lung cancer. The purpose of this study was to evaluate the imaging features of STM from lung cancer using fluorine-18 fluorodeoxyglucose positron emission tomography/computed tomography (F-FDG PET/CT), and assess the impact of STM detected at baseline PET/CT on patient survival.

Methods: Out of 4543 patients with lung cancer who underwent F-FDG PET/CT in our hospital between January 2013 and September 2018, 85 were diagnosed with STM (78 at baseline PET/CT and 7 at restaging PET/CT) and included in the imaging study. Read More

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http://dx.doi.org/10.1186/s12885-020-07080-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7318454PMC

Pulmonary artery enlargement on routine staging F-fluodeoxyglucose positron emission tomography/CT for lung and oesophageal cancer.

Br J Radiol 2020 Jun 25:20200323. Epub 2020 Jun 25.

Department of Nuclear Medicine, Churchill Hospital, Oxford University Hospitals NHS Foundation Trust, Oxford, United Kingdom.

Objective: Pulmonary hypertension (PH) is an underdiagnosed condition associated with poor survival and increased post-operative mortality in lung cancer. CT-based parameters of pulmonary artery enlargement are strong predictors of PH. We used these parameters to investigate pulmonary artery enlargement in lung and oesophageal cancer. Read More

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http://dx.doi.org/10.1259/bjr.20200323DOI Listing

Pre-surgical assessment of mediastinal lymph node metastases in Stage IA non-small-cell lung cancers.

Clin Imaging 2020 Jun 15;68:61-67. Epub 2020 Jun 15.

Department of Radiology, Mount Sinai School of Medicine, NY, NY, USA; Phoenix Veterans Affairs Health Care System, Phoenix, AZ, USA.

Objective: Evaluation of sensitivity and specificity of CT and fluorodeoxyglucose-positron emission tomography for pre-surgical staging of mediastinal lymph node metastases (N2/N3) of non-small-cell-lung-cancers ≤30 mm.

Methods: We reviewed a total of 263 patients from a prospective cohort study, who underwent resection including mediastinal lymph nodes, for first primary non-small-cell-lung-cancer ≤30 mm in maximum diameter on pre-surgical CT. Cutoff criteria for short-axis diameter on CT of the largest N2/N3 node of 10, 15, and 20 mm and positron emission uptake of 2. Read More

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http://dx.doi.org/10.1016/j.clinimag.2020.06.016DOI Listing

Is Skeletal Imaging Essential in the Staging Workup for Conventional Chondrosarcoma?

Clin Orthop Relat Res 2020 Jun 10. Epub 2020 Jun 10.

A. Gulia, V. Kurisunkal, A. Puri, N. Purandare, S. Gupta, V. Rangarajan, Department of Surgical Oncology, Tata Memorial Hospital, HBNI, Mumbai, India.

Background: Staging of a bone sarcoma before initiating treatment helps orthopaedic oncologists determine the intent of treatment and predicting the prognosis. As per National Comprehensive Cancer Network (NCCN) and European Society for Medical Oncology (ESMO) guidelines, there are no exclusive recommendations for chondrosarcoma staging. They are staged similar to other bone sarcomas even though skeletal metastases are extremely rare in chondrosarcomas. Read More

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http://dx.doi.org/10.1097/CORR.0000000000001357DOI Listing

Metastatic incidence of (PET)CT positive lung hilar and retroperitoneal lymph nodes in esophageal cancer patients.

Surg Oncol 2020 Jun 15;33:170-176. Epub 2020 Feb 15.

Department of Surgery, University Medical Center Utrecht, Utrecht University, Heidelberglaan 100, P.O. Box 85500, 3508 GA, Utrecht, the Netherlands. Electronic address:

Background: Extra-regional lymph node metastases strongly determine treatment options in patients with esophageal cancer. Staging modalities such as (FDG-PET) CT scanning frequently show activity in retroperitoneal and lung hilar lymph nodes. This study evaluated the incidence of histologically confirmed metastases, treatment approach and recurrence patterns in patients with (FDG-PET) CT positivity in these regions. Read More

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http://dx.doi.org/10.1016/j.suronc.2020.02.012DOI Listing

Review of Nonmammary Metastases to the Breast: Imaging and Clinical Presentation.

Curr Probl Diagn Radiol 2020 May 17. Epub 2020 May 17.

Department of Radiology, Mayo Clinic, Rochester, MN.

Objectives: The purpose of our study is to review the imaging findings of breast metastases from nonmammary sources at our institution and to explore the mode of initial detection of these breast metastases.

Methods: In this study, we reviewed our electronic medical record and our breast imaging database for all patients who presented with nonmammary metastases to breasts between 5/1/2009 and 12/1/2019. We reviewed all available imaging data, clinical notes, and pathology reports. Read More

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http://dx.doi.org/10.1067/j.cpradiol.2020.04.010DOI Listing

Targeting and imaging colorectal cancer by activatable cell-penetrating peptides.

Am J Transl Res 2020 15;12(5):1754-1766. Epub 2020 May 15.

Department of Colorectal Surgery, Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, The Sixth Affiliated Hospital of Sun Yat-sen University Guangzhou 510655, Guangdong, China.

While it has been a great challenge to determine the positive status of metastasis lesions, intraoperative tumor imaging, which can show tumor localization and facilitate intraoperative staging of nodal metastases, have enabled surgeons to quickly and accurately perform radical resections. However, to date, there is no accurate method for evaluating nodal status intraoperatively. In this study, we synthesized activatable cell-penetrating peptides (ACPPs) that can specifically recognize colorectal cancer and their nodal status. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7270030PMC

An Fusion Gene in Extraskeletal Undifferentiated Round Cell Sarcoma Expands the Spectrum of Genetic Landscape in the "Ewing-Like" Undifferentiated Round Cell Sarcomas.

Int J Surg Pathol 2020 Jun 7:1066896920929081. Epub 2020 Jun 7.

Department of Pathology & Laboratory Medicine, The Ohio State University Wexner Medical Center, Columbus, OH, USA.

The molecular findings in Ewing sarcoma have greatly expanded in recent years. Furthermore, this is particularly true for the subset termed "Ewing-like" undifferentiated round cell sarcomas in which new translocations have been reported since the fourth edition of the . Amid this expanding genetic landscape, we report a case of extraskeletal undifferentiated round cell "Ewing-like" sarcoma in a 27-year-old female. Read More

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http://dx.doi.org/10.1177/1066896920929081DOI Listing

First-line albumin-bound paclitaxel/carboplatin plus apatinib in advanced pulmonary sarcomatoid carcinoma: A case series and review of the literature.

Medicine (Baltimore) 2020 Jun;99(23):e20667

Department of Surgery, Xuzhou Central Hospital, Xuzhou, China.

Rationale: Pulmonary sarcomatoid carcinoma (PSC) is an uncommon type of non-small cell lung cancer, exhibiting aggressive behavior and resistance to the conventional chemoradiotherapy. To date, the optimal treatment for PSC has not been elucidated.

Patient Concerns: Three male patients including a 69-year-old smoker (Case 1), a 45-year-old non-smoker (Case 2), and a 69-year-old smoker (Case 3) were admitted because of cough, back pain, and loss of body weight respectively. Read More

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http://dx.doi.org/10.1097/MD.0000000000020667DOI Listing
June 2020
5.723 Impact Factor

2-[F]FDG PET/CT radiomics in lung cancer: An overview of the technical aspect and its emerging role in management of the disease.

Methods 2020 Jun 1. Epub 2020 Jun 1.

Department of Nuclear Medicine, University Hospital, RWTH University, Aachen, Germany; Department of Nuclear Medicine & Endocrinology, Paracelsus Medical University, Salzburg, Austria. Electronic address:

Lung cancer is the most common cancer, worldwide, and a major health issue with a remarkable mortality rate. 2-[F]fluoro-2-deoxy-D-glucose positron emission tomography/computed tomography (2-[F]FDG PET/CT) plays an indispensable role in the management of lung cancer patients. Long-established quantitative parameters such as size, density, and metabolic activity have been and are being employed in the current practice to enhance interpretation and improve diagnostic and prognostic value. Read More

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http://dx.doi.org/10.1016/j.ymeth.2020.05.023DOI Listing

Predictive Value of Endobronchial Ultrasound Strain Elastography in Mediastinal Lymph Node Staging: The E-Predict Multicenter Study Results.

Respiration 2020 Jun 3:1-9. Epub 2020 Jun 3.

Department of Pulmonology, Radboudumc, Nijmegen, The Netherlands,

Background: Systematic assessment of lymph node status by endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) is indicated in (suspected) lung cancer. Sampling is herein guided by nodal size and FDG-PET characteristics. Ultrasound strain elastography (SE) might further improve risk stratification. Read More

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http://dx.doi.org/10.1159/000507592DOI Listing

Pattern of Local Failure and its Risk Factors of Locally Advanced Non-small Cell Lung Cancer Treated With Concurrent Chemo-radiotherapy.

Anticancer Res 2020 Jun;40(6):3513-3517

Department of Radiation Oncology, International Medical Center, Saitama Medical University, Hidaka, Japan.

Background/aim: The treatment outcome of locally advanced non-small cell lung cancer (LA-NSCLC) has been improved over the past years but local failure is still common for these patients. The purpose of this study is to analyze the pattern of local failure and its risk factor of concurrent chemo-radiotherapy (CCRT) for locally advanced LA-NSCLC.

Patients And Methods: We evaluated 77 patients treated with CCRT for LA-NSCLC from July 2007 to December 2017 at our institution. Read More

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http://dx.doi.org/10.21873/anticanres.14339DOI Listing

Correlation of Iodine Quantification and FDG Uptake in Early Therapy Response Assessment of Non-small Cell Lung Cancer: Possible Benefit of Dual-energy CT Scan as an Integral Part of PET/CT Examination.

Anticancer Res 2020 Jun;40(6):3459-3468

Department of Imaging Methods, Faculty of Medicine in Pilsen, Charles University and University Hospital in Pilsen, Pilsen, Czech Republic.

Aim: To compare iodine-related and fluorine-18 fluorodeoxyglucose (F-FDG) parameters during staging of lung cancer as well as during early follow-up, while investigating potential use and possible substitutability in the assessment of therapeutic response or prediction.

Patients And Methods: Patients (n=45) with confirmed lung cancer underwent F-FDG positron-emission tomography (PET) using single-source dual-energy computed tomography was performed for staging and early follow-up. Correlation of FDG uptake and iodine-related parameters was assessed and comparison with therapy response was performed. Read More

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http://dx.doi.org/10.21873/anticanres.14332DOI Listing

Care of patients with non-small-cell lung cancer stage III - the Central European real-world experience.

Radiol Oncol 2020 May 28;54(2):209-220. Epub 2020 May 28.

1st Faculty of Medicine of Charles University in Prague, Prague Czech Republic.

Background Management of non-small-cell lung cancer (NSCLC) is affected by regional specificities. The present study aimed at determining diagnostic and therapeutic procedures including outcome of patients with NSCLC stage III in the real-world setting in Central European countries to define areas for improvements. Patients and methods This multicentre, prospective and non-interventional study collected data of patients with NSCLC stage III in a web-based registry and analysed them centrally. Read More

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http://dx.doi.org/10.2478/raon-2020-0026DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7276648PMC

ERS/ESTS/EACTS/ESTRO guidelines for the management of malignant pleural mesothelioma.

Eur Respir J 2020 Jun 11;55(6). Epub 2020 Jun 11.

Dept of Radiation Oncology, Kantonsspital St Gallen, St Gallen, Switzerland.

The European Respiratory Society (ERS)/European Society of Thoracic Surgeons (ESTS)/European Association for Cardio-Thoracic Surgery (EACTS)/European Society for Radiotherapy and Oncology (ESTRO) task force brought together experts to update previous 2009 ERS/ESTS guidelines on management of malignant pleural mesothelioma (MPM), a rare cancer with globally poor outcome, after a systematic review of the 2009-2018 literature. The evidence was appraised using the Grading of Recommendations, Assessment, Development and Evaluation approach. The evidence syntheses were discussed and recommendations formulated by this multidisciplinary group of experts. Read More

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http://dx.doi.org/10.1183/13993003.00953-2019DOI Listing

VATS and Minimally Invasive Resection in Early-Stage NSCLC.

Semin Respir Crit Care Med 2020 Jun 25;41(3):335-345. Epub 2020 May 25.

Division of Cardiovascular and Thoracic Surgery, Department of Surgery, Duke Cancer Institute, Duke University Medical Center, Durham, North Carolina.

Lung carcinoma widely affects men and women in the sixth and seventh decades of life. Thorough workup with radiographic imaging, pathologic diagnosis, and cardiopulmonary functional assessment is key to successful treatment. Accurate staging is essential for both assessing prognosis and directing therapy. Read More

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http://dx.doi.org/10.1055/s-0039-3401991DOI Listing

ERS/ESTS/EACTS/ESTRO guidelines for the management of malignant pleural mesothelioma.

Eur J Cardiothorac Surg 2020 Jul;58(1):1-24

Unit of Thoracic Surgery, Azienda Ospedaliera San Camillo Forlanini, Rome, Italy.

The European Respiratory Society (ERS)/European Society of Thoracic Surgeons (ESTS)/European Association for Cardio-Thoracic Surgery (EACTS)/European Society for Radiotherapy and Oncology (ESTRO) task force brought together experts to update previous 2009 ERS/ESTS guidelines on management of malignant pleural mesothelioma (MPM), a rare cancer with globally poor outcome, after a systematic review of the 2009-2018 literature. The evidence was appraised using the Grading of Recommendations, Assessment, Development and Evaluation approach. The evidence syntheses were discussed and recommendations formulated by this multidisciplinary group of experts. Read More

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http://dx.doi.org/10.1093/ejcts/ezaa158DOI Listing

Lung Cancer And Radiological Imaging.

Curr Radiopharm 2020 May 23. Epub 2020 May 23.

Ospedale San Giovanni e Paolo, ULSS 3 Veneziana, Venezia. Italy.

Background: Lung cancer is the neoplasm with the highest prevalence and mortality rates in the world. Most patients with lung cancer that are symptomatic have hemoptysis, coughing, shortness of breath, chest pain and persistent infections. Less than 10% of patients are asymptomatic when the tumor is detected as an incidental finding. Read More

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http://dx.doi.org/10.2174/1874471013666200523161849DOI Listing

Hodkgin lymphoma concomitant of tuberculosis, a therapeutic challenge for multidisciplinary management.

Cancer Radiother 2020 Jul 19;24(4):335-339. Epub 2020 May 19.

Department of Radiation Oncology, Institut Curie, 25, rue d'Ulm, 75005 Paris, France; University of Versailles, St Quentin, France.

Hodgkin lymphoma (HL) is a disease characterized by a high curability rate, and the treatment benefit-risk balance must be carefully addressed to achieve complete disease control with low risk of long-term toxicities. Most patients are treated with a combination of chemotherapy and radiotherapy, after disease staging and response to treatment evaluated by FDG PET/CT. We report the case of a 28-year-old patient concomitantly diagnosed of a Hodgkin lymphoma and active tuberculosis. Read More

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http://dx.doi.org/10.1016/j.canrad.2020.02.005DOI Listing

Ultrasensitive detection of malignant melanoma using PET molecular imaging probes.

Proc Natl Acad Sci U S A 2020 Jun 21;117(23):12991-12999. Epub 2020 May 21.

Department of Nuclear Medicine, Chonnam National University Medical School and Hwasun Hospital, 58128 Hwasun, Korea;

Malignant melanoma has one of the highest mortality rates of any cancer because of its aggressive nature and high metastatic potential. Clinical staging of the disease at the time of diagnosis is very important for the prognosis and outcome of melanoma treatment. In this study, we designed and synthesized the F-labeled pyridine-based benzamide derivatives -(2-(dimethylamino)ethyl)-5-[F]fluoropicolinamide ([F]DMPY2) and -(2-(dimethylamino)ethyl)-6-[F]fluoronicotinamide ([F]DMPY3) to detect primary and metastatic melanoma at an early stage and evaluated their performance in this task. Read More

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http://dx.doi.org/10.1073/pnas.1922313117DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7293619PMC

Predictors of patient preference for either whole body magnetic resonance imaging (WB-MRI) or CT/ PET-CT for staging colorectal or lung cancer.

J Med Imaging Radiat Oncol 2020 May 14. Epub 2020 May 14.

Centre for Medical Imaging, University College London, Charles Bell House, UK.

Introduction: Whole body magnetic resonance imaging (WB-MRI) may be more efficient in staging cancers, but can be harder for patients to tolerate. We examined predictors of patient preference for WB-MRI vs. CT/ PET-CT for staging colorectal or lung cancer. Read More

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http://dx.doi.org/10.1111/1754-9485.13038DOI Listing

Preliminary Presentation of Metastatic Non-Small Cell Carcinoma of the Lung as Atraumatic Avulsion Fracture of the Lesser Trochanter.

Case Rep Oncol 2020 Jan-Apr;13(1):436-441. Epub 2020 Apr 21.

Orthopaedic Department, Queen Elizabeth Hospital, Gateshead, United Kingdom.

Traumatic avulsion fractures of the lesser trochanter are usually seen along with fractures of the proximal femur and with young adolescents involved in high-intensity sporting injuries. Atraumatic isolated lesser trochanter avulsion in adults are most commonly associated with malignancy. We describe a case of a female in her sixties who was previously fit and healthy with no systemic illness and no history of trauma presenting with groin pain. Read More

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http://dx.doi.org/10.1159/000506451DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7204840PMC

Overuse of Diagnostic Brain Imaging Among Patients With Stage IA Non-Small Cell Lung Cancer.

J Natl Compr Canc Netw 2020 05;18(5):547-554

The University of Texas MD Anderson Cancer Center, Houston, Texas.

Background: Among patients diagnosed with stage IA non-small cell lung cancer (NSCLC), the incidence of occult brain metastasis is low, and several professional societies recommend against brain imaging for staging purposes. The goal of this study was to characterize the use of brain imaging among Medicare patients diagnosed with stage IA NSCLC.

Methods: Using data from linked SEER-Medicare claims, we identified patients diagnosed with AJCC 8th edition stage IA NSCLC in 2004 through 2013. Read More

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http://dx.doi.org/10.6004/jnccn.2019.7384DOI Listing

Integrated CT imaging and tissue immune features disclose a radio-immune signature with high prognostic impact on surgically resected NSCLC.

Lung Cancer 2020 Jun 21;144:30-39. Epub 2020 Apr 21.

Department of Medicine and Surgery, University of Parma, Medical Oncology Unit, University Hospital of Parma, Via Gramsci 14, 43126, Parma, Italy. Electronic address:

Objectives: Qualitative and quantitative CT imaging features might intercept the multifaceted tumor immune microenvironment (TIME), providing a non-invasive approach to design new prognostic models in NSCLC patients.

Materials And Methods: Our study population consisted of 100 surgically resected NSCLC patients among which 31 served as a validation cohort for quantitative image analysis. TIME was classified according to PD-L1 expression and the magnitude of Tumor Infiltrating Lymphocytes (TILs) and further defined as hot or cold by the tissue analysis of effector (CD8-to-CD3/PD-1-to-CD8) or inert (CD8-to-CD3/PD-1-to-CD8) phenotypes. Read More

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http://dx.doi.org/10.1016/j.lungcan.2020.04.006DOI Listing
June 2020
3.958 Impact Factor

Case Report of Immuno-Oncotherapy (IO) Provoked Encephalitis Mimicking Brain Metastasis in a Patient with History of Traumatic Brain Injury.

World Neurosurg 2020 Apr 30;139:483-487. Epub 2020 Apr 30.

Neuroscience Institute, Geisinger Medical Center, Danville, Pennsylvania, USA; Cancer Institute, Geisinger Medical Center, Danville, Pennsylvania, USA. Electronic address:

Background: Immuno-oncotherapy (IO) has revolutionized systemic cancer care but remains experimental in brain tumors. IO treatment risks multiorgan autoimmune inflammatory responses that limit its use. The central nervous system (CNS) is an immune-specialized compartment with restricted cellular access, thus fewer cases are reported for immune-mediated encephalitis. Read More

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http://dx.doi.org/10.1016/j.wneu.2020.04.177DOI Listing

Development and evaluation of a venous computed tomography radiomics model to predict lymph node metastasis from non-small cell lung cancer.

Medicine (Baltimore) 2020 May;99(18):e20074

Department of Computed Tomography and Magnetic Resonance, Hebei Medical University Fourth Affiliated Hospital and Hebei Provincial Tumor Hospital, Shijiazhuang, Hebei Province.

The objective of this study was to develop a venous computed tomography (CT)-based radiomics model to predict the lymph node metastasis (LNM) in patients with non-small cell lung cancer (NSCLC). A total of 411 consecutive patients with NSCLC underwent tumor resection and lymph node (LN) dissection from January 2018 to September 2018 in our hospital. A radiologist with 20 years of diagnostic experience retrospectively reviewed all CT scans and classified all visible LNs into LNM and non-LNM groups without the knowledge of pathological diagnosis. Read More

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http://dx.doi.org/10.1097/MD.0000000000020074DOI Listing

Neuraxial dysraphism in associated syndrome due to improper mesenchymal transition.

Neurol Genet 2020 Jun 1;6(3):e414. Epub 2020 Apr 1.

National Institutes of Health (J.S.R., A.J.C., H.W., Z.Z.), National Cancer Institute Neuro-Oncology Branch; National Institutes of Health (D.P.A., J.D.H.), National Institute of Neurological Disorders and Stroke, Surgical Neurology Branch; National Institutes of Health (Y.P., A.J., K.P.), Eunice Kennedy Shriver National Institute of Child Health and Human Development, Section on Medical Neuroendocrinology; Georgetown Hospital (M.A.N.), Internal Medicine and Pediatrics, Washington DC; National Institutes of Health (J.P.M., D.R.D.), National Institute of Neurological Disorders and Stroke, Mouse Imaging Facility, Bethesda, MD; George Washington University (J.G.S.), Radiology, Washington DC; National Library of Medicine (J.G.S.), MedPix®; National Institutes of Health (M.M.M.), Center for Cancer Research, National Cancer Institute, Laboratory of Pathology; and National Institutes of Health (R.H.K., B.A.K.), National Heart Lung and Blood Institute, Translational Vascular Medicine Branch, Bethesda, MD.

Objective: To investigate the effect of somatic, postzygotic, gain-of-function mutation of Endothelial Per-Arnt-Sim (PAS) domain protein 1 () encoding hypoxia-inducible factor-2α (HIF-2α) on posterior fossa development and spinal dysraphism in gain-of-function syndrome, which consists of multiple paragangliomas, somatostatinoma, and polycythemia.

Methods: Patients referred to our institution for evaluation of new, recurrent, and/or metastatic paragangliomas/pheochromocytoma were confirmed for gain-of-function syndrome by identification of the gain-of-function mutation in resected tumors and/or circulating leukocytes. The posterior fossa, its contents, and the spine were evaluated retrospectively on available MRI and CT images of the head and neck performed for tumor staging and restaging. Read More

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http://dx.doi.org/10.1212/NXG.0000000000000414DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7164966PMC

[Recent progress of positron radionuclide labeled small molecule inhibitors of prostate specific membrane antigen for PET/CT imaging of prostate cancer].

Sheng Wu Yi Xue Gong Cheng Xue Za Zhi 2020 Apr;37(2):219-224

Department of Nuclear Medicine, Laboratory of Clinical Nuclear Medicine, West China Hospital, Sichuan University, Chengdu 610041, P.R.China.

Prostate cancer is the most common tumor of the urinary system, and its mortality rate is second only to lung cancer. With the specific and high expression on the surface of prostate cancer cells, prostate-specific membrane antigen (PSMA) has been an ideal theranostic target of prostate cancer with great clinical significance and research value. Positron emission tomography/computed tomography (PET/CT), a new modality of molecular imaging combining functional metabolic information and anatomical structure, provides high diagnostic performance for cancer detection. Read More

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http://dx.doi.org/10.7507/1001-5515.201911073DOI Listing

A national audit of radiology practice in cancer multidisciplinary team meetings.

Clin Radiol 2020 Apr 20. Epub 2020 Apr 20.

Clinical Radiology and Quality Improvement Committee (CRQIC), The Royal College of Radiologists, 63 Lincoln's Inn Fields, London, WC2A 3JW, UK.

Aim: A national audit reviewing compliance of imaging departments with the Royal College of Radiologist (RCR) standards for cancer multidisciplinary team meetings (MDTMs).

Materials And Methods: The audit consisted of a generic and subspecialty component completed for breast, colorectal, and lung cancer MDTMs.

Results: The study achieved the highest response from a RCR national audit with 145/191 (76%) hospitals responding. Read More

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http://dx.doi.org/10.1016/j.crad.2020.03.031DOI Listing

Lung cancer staging: State of the art in the era of ablative therapies and surgical segmentectomy.

Respirology 2020 Apr 22. Epub 2020 Apr 22.

Division of Thoracic Surgery, Toronto General Hospital, University Health Network, University of Toronto, Toronto, ON, Canada.

Implementation of lung cancer screening and improvements in imaging are expected to increase the proportion of lung cancer diagnosed at an early stage. The standard of care has historically been anatomic lobectomy; however, there is now an array of surgical and non-surgical approaches for management of local disease either in active use or under investigation. By their nature, these new modalities offer a theoretical trade-off of reduced morbidity in exchange for reduced efficacy in the setting of advanced disease. Read More

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http://dx.doi.org/10.1111/resp.13827DOI Listing

Clinical characteristics and work-up of small to intermediate-sized pulmonary nodules in a Chinese dedicated cancer hospital.

Cancer Biol Med 2020 Feb;17(1):199-207

Department of Radiology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin, Tianjin's Clinical Research Center for Cancer, Tianjin 300060, China.

To evaluate the characteristics and work-up of small to intermediate-sized pulmonary nodules in a Chinese dedicated cancer hospital. Patients with pulmonary nodules 4-25 mm in diameter detected computed tomography (CT) in 2013 were consecutively included. The analysis was restricted to patients with a histological nodule diagnosis or a 2-year follow-up period without nodule growth confirming benign disease. Read More

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http://dx.doi.org/10.20892/j.issn.2095-3941.2019.0028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7142837PMC
February 2020

Invasive Staging Procedures Do Not Prevent Nodal Metastases From Being Missed in Stage I Lung Cancer.

Ann Thorac Surg 2020 Apr 10. Epub 2020 Apr 10.

Section of Thoracic Surgery, Department of Surgery, Yale School of Medicine, New Haven, Connecticut. Electronic address:

Background: Up to 20% of clinical stage I lung cancer patients harbor lymph node metastases that go undetected (missed) during the clinical staging evaluation. We investigated to what degree the addition of invasive nodal staging procedures to imaging, as currently practiced, prevents radiographically occult nodal metastases from being missed during the clinical staging evaluation.

Methods: Treatment-naive patients, imaged by positron emission tomography and computed tomography, who underwent lobectomy for clinical stage I lung cancer from 2012 to 2017 in The Society of Thoracic Surgeons General Thoracic Surgery Database were studied. Read More

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http://dx.doi.org/10.1016/j.athoracsur.2020.03.026DOI Listing

Dynamic chest radiography: Novel and less-invasive imaging approach for preoperative assessments of pleural invasion and adhesion.

Radiol Case Rep 2020 Jun 6;15(6):702-704. Epub 2020 Apr 6.

Department of Thoracic, Cardiovascular and General Surgery, Kanazawa University, Kanazawa, Japan.

Here, we report a case of lung cancer with preoperatively predicted invasion to the parietal pleura on dynamic chest radiography (DCR). An 82-year-old patient was referred for staging of a right lung tumor. Preoperative DCR revealed invasion or adhesion of the tumor to the chest wall, and intraoperative findings revealed invasion of the tumor to the parietal pleura. Read More

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http://dx.doi.org/10.1016/j.radcr.2020.02.019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7138928PMC

Lymph node assessment in early stage non-small cell lung cancer lymph node dissection or sampling?

Authors:
Gail E Darling

Gen Thorac Cardiovasc Surg 2020 Apr 7. Epub 2020 Apr 7.

Professor of Surgery, Division of Thoracic Surgery, Kress Family Chair in Esophageal Cancer, University of Toronto, University Health Network, Toronto General Hospital, 200 Elizabeth St 9N-955, Toronto, ON, M5G 2C4, Canada.

Lymph node assessment is an essential component of the treatment of lung cancer. Identification of the correct "N" stage is important for staging which in turn determines treatment. Assessment of lymph nodes may be accomplished using imaging with CT scan and PET-CT, invasive techniques such as mediastinoscopy, endobronchial ultrasound transbronchial needle aspiration (EBUS-TBNA) or endoscopic ultrasound fine needle aspiration (EUS-FNA). Read More

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http://dx.doi.org/10.1007/s11748-020-01345-yDOI Listing

Performance evaluation of developed dedicated breast PET scanner and improvement of the spatial resolution by wobbling: a Monte Carlo study.

Jpn J Radiol 2020 Apr 6. Epub 2020 Apr 6.

Research Center for Molecular and Cellular Imaging, Tehran University of Medical Sciences, Tehran, Iran.

Purpose: Molecular imaging, particularly PET scanning, has become an important cancer diagnostic tool. Whole-body PET is not effective for local staging of cancer because of their declining efficiency in detecting small lesions. The preliminary results of the performance evaluation of designed dedicated breast PET scanner presented. Read More

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http://dx.doi.org/10.1007/s11604-020-00966-wDOI Listing

[Risk factors for lung cancer based on low-dose computed tomography screening].

Zhonghua Zhong Liu Za Zhi 2020 Mar;42(3):222-227

PET-CT Center, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China.

To analyze the risk factors related to lung cancer in participants with low-dose computed tomography (LDCT) screening, to provide data support for identifying high-risk groups of lung cancer and to improve the effectiveness of LDCT lung cancer screening. A total of 5 366 asymptomatic subjects (2 762 males and 2 604 females) who underwent LDCT lung cancer screening were recruited at Cancer Hospital, Chinese Academy of Medical Sciences from 2014 to 2017. The result of LDCT and the risk factors of participants were analyzed. Read More

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http://dx.doi.org/10.3760/cma.j.cn112152-20190809-00509DOI Listing

A two-way comparison of whole-body 18FDG PET-CT and whole-body contrast-enhanced MRI for distant metastasis staging in patients with malignant tumors: a meta-analysis of 13 prospective studies.

Ann Palliat Med 2020 Mar 18;9(2):247-255. Epub 2020 Mar 18.

Department of Nuclear Medicine, The First Affiliated Hospital of Guangxi Medical University, Nanning 530021, China.

Background: The correct staging of distant metastasis is crucial in deciding an adequate course of therapy for cancer patients. This meta-analysis was carried out to produce an evaluation and comparison of the performances of 18F-fluorodeoxyglucose positron emission tomography-computed tomography (18FDG PET-CT) and contrastenhanced magnetic resonance imaging (MRI) in detecting distant metastasis in patients suffering malignant tumors. Systematic literature searches of the MEDLINE and Embase databases were conducted to identify relevant studies in the period from December 31, 1950 to August 1, 2019. Read More

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http://dx.doi.org/10.21037/apm.2020.02.30DOI Listing

18F-PSMA 1007 in Suspected Renal Cell Carcinoma.

Clin Nucl Med 2020 May;45(5):377-378

From the Jaber Alahmad Centre for Molecular Imaging, Shuwaikh, Kuwait.

A 60-year-old man with suspected right renal cell carcinoma underwent F-FDG PET/CT and F prostate-specific membrane antigen (PSMA) 1007 PET/CT scan. Compared with the F-FDG PET/CT scan, F-PSMA 1007 PET/CT showed intense tracer concentration in the primary tumor in the right kidney and intense tracer concentration consistently in all lung nodules. Unlike noted in previous pilot studies with Ga-PSMA, we observed that the primary renal tumor also showed intense tracer avidity with F-PSMA 1007. Read More

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http://dx.doi.org/10.1097/RLU.0000000000003002DOI Listing
May 2020
3.931 Impact Factor

Prognostic value of metabolic parameters measured by F-fluorodeoxyglucose positron emission tomography-computed tomography in surgically resected non-small cell lung cancer patients.

World J Nucl Med 2020 Jan-Mar;19(1):8-14. Epub 2020 Feb 27.

Department of Nuclear Medicine and Molecular Imaging, Tata Memorial Hospital, Homi Bhabha National Institute, Mumbai, Maharashtra, India.

F-fluorodeoxyglucose positron emission tomography-computed tomography-derived metabolic parameters can play a role in prognostication. We investigated the prognostic value of various metabolic parameters such as maximum standardized uptake value (SUV), mean SUV (SUV), whole-body metabolic tumor volume (WBMTV), and whole-body total lesion glycolysis (WBTLG) in surgically resected non-small cell lung cancer (NSCLC) patients. We retrospectively reviewed 153 patients with NSCLC who underwent surgical resection. Read More

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http://dx.doi.org/10.4103/wjnm.WJNM_26_19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7067134PMC
February 2020

Radiotherapy planning and Molecular Imaging in Lung Cancer.

Curr Radiopharm 2020 03 18. Epub 2020 Mar 18.

Nuclear Medicine Unit, Azienda Unità Sanitaria Locale - IRCCS, Italy.

The goal of the radiotherapy (RT) planning process is to select and delineate target volumes with the best accuracy on the basis of all the available diagnostic information and the knowledge of the physiology of the disease. The recommendation of the International Atomic Energy Agency (IAEA) expert panel, is that an appropriately timed and technically adequate 2-[18F]fluoro-2-deoxy-d-glucose/Positron Emission Tomography-Computer Tomography (18F-FDG-PET/CT) imaging is an essential component in the radiotherapy treatment planning (RTP) process for lung cancer [1]. Each patient considered for radical radiotherapy should have had a staging 18F-FDG-PET/CT for RTP, acquired in treatment position and co-registered with the planning CT [2]. Read More

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http://dx.doi.org/10.2174/1874471013666200318144154DOI Listing

Image-guided video-assisted thoracoscopic resection (iVATS): Translation to clinical practice-real-world experience.

J Surg Oncol 2020 Jun 12;121(8):1225-1232. Epub 2020 Mar 12.

Department of Surgery, Brigham & Women's Hospital, Boston, Massachusetts.

Objective: We developed a novel approach for localization and resection of lung nodules, using image-guided video-assisted thoracoscopic surgery (iVATS). We report our experience of translating iVATS into clinical care.

Methods: Methodology and workflow for iVATS developed as part of the Phase I/II trial were used to train surgeons, radiologists, anesthesiologists, and radiology technologists. Read More

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http://dx.doi.org/10.1002/jso.25897DOI Listing

[The Outcome of Preoperative Chemoradiotherapy for Advanced Lower Rectal Cancer-The Possibility of an Omission of the Lateral Dissection].

Gan To Kagaku Ryoho 2019 Dec;46(13):1957-1959

Dept. of Digestive Tract and General Surgery, Saitama Medical Center.

The objective of this study was to evaluate the outcomes of selective LPLN dissection(LPLD)based on pretreatment imaging in patients with advanced low rectal cancer treated with pre-operative CRT. We reviewed 32 patients without suspected LPLN metastasis based on the MDCT or MRI results before CRT. These patients underwent total mesorectal excision (TME)without LPLD. Read More

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December 2019

Treatment of Patients With Late-Stage Colorectal Cancer: ASCO Resource-Stratified Guideline.

JCO Glob Oncol 2020 Mar;6:414-438

Dartmouth-Hitchcock Medical Center, Lebanon, NH.

Purpose: To provide expert guidance to clinicians and policymakers in resource-constrained settings on the management of patients with late-stage colorectal cancer.

Methods: ASCO convened a multidisciplinary, multinational Expert Panel that reviewed existing guidelines, conducted a modified ADAPTE process, and used a formal consensus process with additional experts for two rounds of formal ratings.

Results: Existing sets of guidelines from four guideline developers were identified and reviewed; adapted recommendations from five guidelines form the evidence base and provided evidence to inform the formal consensus process, which resulted in agreement of ≥ 75% on all recommendations. Read More

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http://dx.doi.org/10.1200/JGO.19.00367DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7124947PMC

Exploring technical issues in personalized medicine: NSCLC survival prediction by quantitative image analysis-usefulness of density correction of volumetric CT data.

Radiol Med 2020 Jul 3;125(7):625-635. Epub 2020 Mar 3.

Dipartimento Diagnostica per Immagini, Radioterapia oncologica ed Ematologia, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Largo Agostino Gemelli 8, Largo Francesco Vito 1, 00168, Rome, Italy.

The aim of this study was to apply density correction method to the quantitative image analysis of non-small cell lung cancer (NSCLC) computed tomography (CT) images, determining its influence on overall survival (OS) prediction of surgically treated patients. Clinicopathological (CP) data and preoperative CT scans, pre- and post-contrast medium (CM) administration, of 57 surgically treated NSCLC patients, were retrospectively collected. After CT volumetric density measurement of primary gross tumour volume (GTV), aorta and tracheal air, density correction was conducted on GTV (reference values: aortic blood and tracheal air). Read More

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http://dx.doi.org/10.1007/s11547-020-01157-3DOI Listing

18F-FDG PET/CT and whole-body MRI diagnostic performance in M staging for non-small cell lung cancer: a systematic review and meta-analysis.

Eur Radiol 2020 Jul 3;30(7):3641-3649. Epub 2020 Mar 3.

Postgraduate Program in Medicine and Health Sciences, Pontificia Universidade Catolica do Rio Grande do Sul, Av. Ipiranga, 6690, Porto Alegre, 90619900, Brazil.

Objectives: To evaluate the diagnostic test accuracy of 18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT), whole-body magnetic resonance imaging (WB-MRI), and whole-body diffusion-weighted imaging (WB-DWI) for the detection of metastases in patients with non-small cell lung cancer (NSCLC).

Methods: MEDLINE, Embase, and Cochrane Library databases were searched up to June 2019. Studies were selected if they reported data that could be used to construct contingency tables to compare 18F-FDG PET/CT, WB-MRI, and WB-DWI. Read More

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http://dx.doi.org/10.1007/s00330-020-06703-1DOI Listing
July 2020
4.014 Impact Factor

Application of computed tomography, positron emission tomography-computed tomography, magnetic resonance imaging, endobronchial ultrasound, and mediastinoscopy in the diagnosis of mediastinal lymph node staging of non-small-cell lung cancer: A protocol for a systematic review.

Medicine (Baltimore) 2020 Feb;99(9):e19314

Department of Respiratory, Lanzhou University Second Hospital.

Background: Ruling out distant metastases, non-small cell lung cancer (NSCLC)treatment depends on the results of mediastinal node staging (N staging). Several diagnostic methods play central roles in mediastinal N staging. This study is intended to evaluate the existing diagnostic methods and report quality, and to search for the best method for staging mediastinal lymph nodes. Read More

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http://dx.doi.org/10.1097/MD.0000000000019314DOI Listing
February 2020
5.723 Impact Factor