8,938 results match your criteria Imaging in Juvenile Pilocytic Astrocytoma


Modelling MR and clinical features in grade II/III astrocytomas to predict IDH mutation status.

Eur J Radiol 2019 May 14;114:120-127. Epub 2019 Mar 14.

Department of Brain Repair and Rehabilitation, UCL Institute of Neurology, London, UK; National Hospital for Neurology and Neurosurgery, Queen Square, London, UK.

Background And Purpose: There is increasing evidence that many IDH wildtype (IDHwt) astrocytomas have a poor prognosis and although MR features have been identified, there remains diagnostic uncertainty in the clinic. We have therefore conducted a comprehensive analysis of conventional MR features of IDHwt astrocytomas and performed a Bayesian logistic regression model to identify critical radiological and basic clinical features that can predict IDH mutation status.

Materials And Methods: 146 patients comprising 52 IDHwt astrocytomas (19 WHO Grade II diffuse astrocytomas (A II) and 33 WHO Grade III anaplastic astrocytomas (A III)), 68 IDHmut astrocytomas (53 A II and 15 A III) and 26 GBM were studied. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0720048X193009
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http://dx.doi.org/10.1016/j.ejrad.2019.03.003DOI Listing
May 2019
1 Read

Isocitrate dehydrogenase1 mutation reduces the pericyte coverage of microvessels in astrocytic tumours.

J Neurooncol 2019 Apr 19. Epub 2019 Apr 19.

Department of Neurology, Tangdu Hospital, The Fourth Military Medical University, Xi'an, 710032, Shaanxi, China.

Introduction: Tumour-associated angiogenesis is associated with the malignancy and poor prognosis of glioma. Isocitrate dehydrogenase (IDH) mutations are present in the majority of lower-grade (WHO grade II and III) and secondary glioblastomas, but their roles in tumour angiogenesis remain unclear.

Methods: Using magnetic resonance imaging (MRI), the cerebral blood flow (CBF) of IDH-mutated glioma was measured and compared with the IDH-wildtype glioma. Read More

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http://link.springer.com/10.1007/s11060-019-03156-5
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http://dx.doi.org/10.1007/s11060-019-03156-5DOI Listing
April 2019
1 Read

Usefulness of [C] Methionine PET in the Differentiation of Tumefactive Multiple Sclerosis from High Grade Astrocytoma.

Neurol Med Chir (Tokyo) 2019 Apr 17. Epub 2019 Apr 17.

Department of Neurosurgery, Tokyo Medical and Dental University.

Tumefactive multiple sclerosis (tumefactive MS) is an atypical variant of MS characterized by a large isolated demyelinating lesion. Because tumefactive MS mimics high grade astrocytoma clinically and radiologically, it is difficult to distinguish between the two using only traditional diagnostic modalities, such as routine magnetic resonance imaging. [C] methionine positron emission tomography (MET PET) has been known as a useful diagnostic tool for glioma. Read More

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http://dx.doi.org/10.2176/nmc.oa.2018-0287DOI Listing

A vascular-task response dependency and its application in functional imaging of brain tumors.

J Neurosci Methods 2019 Apr 13. Epub 2019 Apr 13.

Department of Radiology, Weill Cornell Medicine, New York, NY, USA; Functional MRI Laboratory, Department of Radiology, Memorial Sloan-Kettering Cancer Center, New York, NY, USA; Brain Tumor Center, Memorial Sloan-Kettering Cancer Center, New York, NY, USA; Department of Neuroscience, Weill-Cornell Graduate School of the Medical Sciences, New York, NY, USA.

Purpose: Preoperative functional MRI (fMRI) is limited by a muted BOLD response caused by abnormal vasoreactivity and resultant neurovascular uncoupling adjacent to malignant brain tumors. We propose to overcome this limitation and more accurately identify eloquent areas adjacent to brain tumors by independently assessing vasoreactivity using breath-holding and incorporating these data into the fMRI analysis.

Methods: Local vasoreactivity using a breath-holding paradigm with the same timing as the functional motor and language tasks was determined in 16 patients (9 glioblastomas, 1 anaplastic astrocytoma, 5 low grade astrocytomas, and 1 metastasis) and 6 healthy control subjects. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01650270193011
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http://dx.doi.org/10.1016/j.jneumeth.2019.04.004DOI Listing
April 2019
3 Reads

Prognostic Value of O-(2-[F]Fluoroethyl)-L-Tyrosine PET/CT in Newly Diagnosed WHO 2016 Grade II and III Glioma.

Mol Imaging Biol 2019 Apr 11. Epub 2019 Apr 11.

Department of Nuclear Medicine, University Hospital Würzburg, Oberdürrbacher Str. 6, 97080, Wurzburg, Germany.

Purpose: The use of [F]fluoroethyl)-L-tyrosine ([F]FET) positron emission tomography/computed tomography (PET/CT) has proven valuable in brain tumor management. This study aimed to investigate the prognostic value of radiotracer uptake in newly diagnosed grade II or III gliomas according to the current 2016 World Health Organization (WHO) classification.

Procedures: A total of 35 treatment-naive patients (mean age, 48 ± 17 years) with histologically proven WHO grade II or III gliomas as defined by the current 2016 WHO classification were included. Read More

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http://link.springer.com/10.1007/s11307-019-01357-y
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http://dx.doi.org/10.1007/s11307-019-01357-yDOI Listing
April 2019
2 Reads

Microsurgical management of fourth ventricle astrocytoma via the median suboccipital keyhole approach: A review of 12 cases.

Authors:
Li Guowei Lan Qing

World Neurosurg 2019 Apr 8. Epub 2019 Apr 8.

Department of Neurosurgery, the Second Affiliated Hospital of Soochow University, SanXiang Road 1005. Suzhou 215004. China. Electronic address:

Objective: To investigate the clinical effect and surgical techniques of fourth ventricle astrocytoma resection through the median suboccipital keyhole approach.

Methods: Twelve patients received tumor resection through the median suboccipital keyhole approach in our department. A 4-cm median suboccipital excision starting 1 cm under the foramen magnum region and directed vertically upward was applied. Read More

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http://dx.doi.org/10.1016/j.wneu.2019.02.156DOI Listing

A radiomics nomogram may improve the prediction of IDH genotype for astrocytoma before surgery.

Eur Radiol 2019 Apr 10. Epub 2019 Apr 10.

Department of Radiology, The first hospital of Shanxi Medical University, Taiyuan, 030001, Shanxi Province, China.

Objectives: To develop and validate a radiomics nomogram to preoperative prediction of isocitrate dehydrogenase (IDH) genotype for astrocytomas, which might contribute to the pretreatment decision-making and prognosis evaluating.

Methods: One hundred five astrocytomas (Grades II-IV) with contrast-enhanced T1-weighted imaging (CE-T1WI), T2 fluid-attenuated inversion recovery (T2FLAIR), and apparent diffusion coefficient (ADC) map were enrolled in this study (training cohort: n = 74; validation cohort: n = 31). IDH1/2 genotypes were determined using Sanger sequencing. Read More

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http://dx.doi.org/10.1007/s00330-019-06056-4DOI Listing

Magnetic resonance imaging and proton magnetic resonance spectroscopy for differentiating between enhanced gliomas and malignant lymphomas.

World Neurosurg 2019 Apr 2. Epub 2019 Apr 2.

Department of Neurosurgery, Fujita Health University, Toyoake, Aichi, Japan.

Objective: Although the treatment strategies for malignant lymphomas and gliomas differ, it is usually difficult to preoperatively distinguish between the two. Magnetic resonance spectroscopy (MRS) was recently reported to be useful for preoperative diagnoses; however, MRS data analysis using LCModel, which is a quantitative and objective method, was performed in only a few of the existing reports.

Methods: The clinical characteristics, conventional magnetic resonance imaging findings and MRS parameters using LCModel were evaluated to identify the factors that can help distinguish between malignant lymphomas and enhanced gliomas. Read More

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http://dx.doi.org/10.1016/j.wneu.2019.03.261DOI Listing
April 2019
7 Reads

Prognostic Significance of Anatomic Origin and Evaluation of Survival Statistics of Astrocytoma Patients-a Tertiary Experience.

Indian J Surg Oncol 2019 Mar 30;10(1):55-60. Epub 2018 Oct 30.

1Department of Biotechnology and Bioinformatics, School of Life Sciences, University of Hyderabad, Hyderabad, Telangana State 500046 India.

Astrocytoma constitutes the most noted malignancies of the central nervous system with worse clinical outcomes in grade IV astrocytoma or glioblastoma multiforme. Owing to poor clinical outcomes with existing therapeutic regime, there is a need to revisit the initial course of treatment. Statistical information of clinicopathological parameters could be used to understand the spread of disease and, in turn, to formulate updated treatment management. Read More

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http://link.springer.com/10.1007/s13193-018-0820-0
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http://dx.doi.org/10.1007/s13193-018-0820-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6414575PMC
March 2019
4 Reads

Holocord Pilocytic Astrocytoma in an Adult: A Rare Case Report and Review of the Literature.

World Neurosurg 2019 Mar 19. Epub 2019 Mar 19.

Memorial Hospital, Neurosurgery Clinic, Ankara, Turkey.

Background: Intramedullary glial neoplasms affecting the entire spinal cord from the cervicomedullary junction to conus medullaris are termed 'holocord tumors'. Pilocytic astrocytomas are relatively uncommon tumors forming holocord involvement. Hitherto 24 holocord astrocytoma cases were reported in the literature. Read More

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http://dx.doi.org/10.1016/j.wneu.2019.03.103DOI Listing
March 2019
1 Read
2.417 Impact Factor

Proliferation-dominant high-grade astrocytoma: survival benefit associated with extensive resection of FLAIR abnormality region.

J Neurosurg 2019 Mar 22:1-8. Epub 2019 Mar 22.

1Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, and China National Clinical Research Center for Neurological Diseases, Center of Brain Tumor, Beijing Institute for Brain Disorders and Beijing Key Laboratory of Brain Tumor, Beijing, China; and.

OBJECTIVEThe aim of this study was to investigate the relationship between extent of resection (EOR) and survival in terms of clinical, molecular, and radiological factors in high-grade astrocytoma (HGA).METHODSClinical and radiological data from 585 cases of molecularly defined HGA were reviewed. In each case, the EOR was evaluated twice: once according to contrast-enhanced T1-weighted images (CE-T1WI) and once according to fluid attenuated inversion recovery (FLAIR) images. Read More

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http://dx.doi.org/10.3171/2018.12.JNS182775DOI Listing
March 2019
2 Reads

Gliomatosis Cerebri Among Children and Adolescents: An Individual-Patient Data Meta-analysis of 182 Patients.

J Child Neurol 2019 Mar 19:883073819836551. Epub 2019 Mar 19.

1 Department of Hygiene, Epidemiology and Medical Statistics, Medical School, National and Kapodistrian University of Athens, Athens, Greece.

Background:: Gliomatosis cerebri is a rare but fatal widespread infiltrating central nervous system tumor. We aimed to describe diagnostic and prognostic features of gliomatosis cerebri among children and adolescents.

Methods:: We conducted a systematic literature review for published case reports and case series on patients with histologically confirmed gliomatosis cerebri and extracted data on an individual patient level for those aged 0-18 years. Read More

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http://dx.doi.org/10.1177/0883073819836551DOI Listing
March 2019
5 Reads

Arterial Spin Labeling for Glioma Grade Discrimination: Correlations with IDH1 Genotype and 1p/19q Status.

Transl Oncol 2019 May 15;12(5):749-756. Epub 2019 Mar 15.

Department of Radiology, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, 651 Dongfeng East Road, Guangzhou 510060, China. Electronic address:

Since accurate grading of gliomas has important clinical value, the aim of this study is to evaluate the diagnostic efficacy of perfusion values derived from arterial spin labeling (ASL) to grade gliomas. In addition, the correlation between perfusion and isocitrate dehydrogenase 1 (IDH1) genotypes and chromosome arms 1p and 19q (1p/19q) status of gliomas was assessed. A total of 52 cases of supratentorial gliomas in adults who received ASL imaging were enrolled in this retrospective study. Read More

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http://dx.doi.org/10.1016/j.tranon.2019.02.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6423366PMC
May 2019
3 Reads

Glucose transporter 1-mediated vascular translocation of nanomedicines enhances accumulation and efficacy in solid tumors.

J Control Release 2019 Mar 4;301:28-41. Epub 2019 Mar 4.

Innovation Center of Nanomedicine (iCONM), Kawasaki Institute of Industrial Promotion, 3-25-14 Tonomachi, Kawasaki-ku, Kawasaki 210-0821, Japan; Policy Alternatives Research Institute, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan. Electronic address:

Nanomedicine modification with ligands directed to receptors on tumor blood vessels has the potential for selectively enhancing nanomedicine accumulation in malignant tissues by overcoming the vascular barrier of tumors. Nevertheless, the development of broadly applicable ligand approaches capable of promoting the transvascular transport of nanomedicines in a wide spectrum of tumors has been elusive so far. By considering the indispensable and persistent glycolytic fueling of tumors, we developed glucose-installed polymeric micelles loading cisplatin (Gluc-CDDP/m) targeting the glucose transporter 1 (GLUT1), which is overexpressed in most tumors and present on vascular endothelial cells, toward improving the delivery efficiency and therapeutic efficacy. Read More

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http://dx.doi.org/10.1016/j.jconrel.2019.02.021DOI Listing
March 2019
1 Read

Prognostic value of subventricular zone involvement in relation to tumor volumes defined by fused MRI and O-(2-[F]fluoroethyl)-L-tyrosine (FET) PET imaging in glioblastoma multiforme.

Radiat Oncol 2019 Mar 4;14(1):37. Epub 2019 Mar 4.

Department of Oncology, Radiotherapy and Gynecologic Oncology, Faculty of Health Sciences, Nicolaus Copernicus University Toruń, Bydgoszcz, Poland.

Background: Subventricular zone (SVZ) involvement is associated with a dismal prognosis in patients with glioblastoma multiforme (GBM). Dual-time point (dtp) O-(2-[F]fluoroethyl)-L-tyrosine (FET) PET/CT (PET) may be a time- and cost-effective alternative to dynamic FET PET, but its prognostic value, particularly with respect to SVZ involvement, is unknown.

Methods: Thirty-five patients had two scans 5-15 and 50-60 min after i. Read More

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http://dx.doi.org/10.1186/s13014-019-1241-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6398237PMC
March 2019
3 Reads

Regorafenib in patients with recurrent high-grade astrocytoma.

J Cancer Res Clin Oncol 2019 Apr 28;145(4):1037-1042. Epub 2019 Feb 28.

Division of Clinical Neurooncology, Department of Neurology, University Hospital Essen, University Duisburg-Essen, 45147, Essen, Germany.

Purpose: Antiangiogenic treatment approaches have failed to improve outcome in randomized trials of high-grade astrocytoma. One key mechanism of resistance to antiangiogenic treatment may concern the upregulation of alternative pro-angiogenic pathways. Regorafenib is a potent multikinase inhibitor that may alter some of those pathways. Read More

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http://dx.doi.org/10.1007/s00432-019-02868-5DOI Listing
April 2019
3 Reads

Deep Learning-Based Framework for Identification of Glioblastoma Tumor using Hyperspectral Images of Human Brain.

Sensors (Basel) 2019 Feb 22;19(4). Epub 2019 Feb 22.

Department of Bioengineering, The University of Texas at Dallas, 800 W. Campbell Road, Richardson, TX 75080, USA.

The main goal of brain cancer surgery is to perform an accurate resection of the tumor, preserving as much normal brain tissue as possible for the patient. The development of a non-contact and label-free method to provide reliable support for tumor resection in real-time during neurosurgical procedures is a current clinical need. Hyperspectral imaging is a non-contact, non-ionizing, and label-free imaging modality that can assist surgeons during this challenging task without using any contrast agent. Read More

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http://www.mdpi.com/1424-8220/19/4/920
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http://dx.doi.org/10.3390/s19040920DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6412736PMC
February 2019
3 Reads

Correlation of Ki-67 Index with Volumetric Segmentation and its Value as a Prognostic Marker in Glioblastoma.

World Neurosurg 2019 Feb 18. Epub 2019 Feb 18.

Department of Neurosurgery, University Medicine of Rostock, Rostock, Germany.

Objective: Previous research has shown a strong correlation between the Ki-67 proliferation index and grade of malignancy in astrocytoma. Ki-67 has also shown encouraging results as a prognostic marker for patients' overall survival (OS). We focus on whether the index is linked to the appearance of glioblastoma on pretreatment magnetic resonance imaging (MRI) or to OS. Read More

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http://dx.doi.org/10.1016/j.wneu.2019.02.006DOI Listing
February 2019

Carbon ion radiotherapy boost in the treatment of glioblastoma: a randomized phase I/III clinical trial.

Cancer Commun (Lond) 2019 02 20;39(1). Epub 2019 Feb 20.

Department of Radiation Oncology, Shanghai Proton and Heavy Ion Center, Pudong, 4365 Kangxin Road, Shanghai, 201321, P. R. China.

Background: Glioblastoma (GBM) is a highly virulent tumor of the central nervous system, with a median survival < 15 months. Clearly, an improvement in treatment outcomes is needed. However, the emergence of these malignancies within the delicate brain parenchyma and their infiltrative growth pattern severely limit the use of aggressive local therapies. Read More

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http://dx.doi.org/10.1186/s40880-019-0351-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6383247PMC
February 2019

Detection of occult neoplastic infiltration in the corpus callosum and prediction of overall survival in patients with glioblastoma using diffusion tensor imaging.

Eur J Radiol 2019 Mar 15;112:106-111. Epub 2019 Jan 15.

Department of Radiology, Division of Neuroradiology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA; Department of Cellular and Molecular Physiology, University of Liverpool, Liverpool, UK.

Objective: Corpus callosum (CC) involvement is a poor prognostic factor in patients with glioblastoma (GBM). The purpose of this study was to determine whether diffusion tensor imaging (DTI) can quantify occult tumor infiltration in the CC and predict the overall survival in GBM patients.

Methods: Forty-eight patients with pathologically proven GBM and 17 normal subjects were included in this retrospective study. Read More

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http://dx.doi.org/10.1016/j.ejrad.2019.01.015DOI Listing
March 2019
1 Read

The benefit of surveillance imaging for paediatric cerebellar pilocytic astrocytoma.

Childs Nerv Syst 2019 May 15;35(5):801-805. Epub 2019 Feb 15.

Department of Paediatric Oncology, Alder Hey Children's Hospital, Eaton Road, Liverpool, L12 2AP, UK.

Objectives: Paediatric cerebellar pilocytic astrocytomas (PA) (WHO grade 1) are amongst the most common of childhood brain tumours and are generally amenable to resection, with surgery alone being curative in the majority of cases. There is, however, a lack of consensus regarding the frequency and duration of post-treatment MRI surveillance for these tumours. This is important, as follow-up imaging is a significant use of resources and often associated with patient and family anxiety. Read More

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http://link.springer.com/10.1007/s00381-019-04078-3
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http://dx.doi.org/10.1007/s00381-019-04078-3DOI Listing
May 2019
9 Reads

Atypical Presentation of Glioblastoma Multiforme.

Eur J Case Rep Intern Med 2018 27;5(9):000954. Epub 2018 Sep 27.

Neurology Department, Henry Ford Health System, Detroit, MI, USA.

Background: Glioblastoma multiforme (GBM) is a highly malignant glial tumour classified by the World Health Organization (WHO) as a stage IV astrocytoma. It varies in shape and size and can be cystic, vascular and necrotic. It often appears as a ring-enhancing lesion on magnetic resonance imaging (MRI). Read More

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http://dx.doi.org/10.12890/2018_000954DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346815PMC
September 2018
3 Reads

Phase I/II trial testing safety and immunogenicity of the multipeptide IMA950/poly-ICLC vaccine in newly diagnosed adult malignant astrocytoma patients.

Neuro Oncol 2019 Feb 12. Epub 2019 Feb 12.

Department of Oncology, Clinical Research Unit, Dr Dubois Ferrière Dinu Lipatti Research Foundation, Geneva University Hospital, Geneva, Switzerland.

Background: Peptide vaccines offer the opportunity to elicit glioma-specific T cells with tumor killing ability. Using antigens eluted from the surface of glioblastoma samples, we designed a phase I/II study to test safety and immunogenicity of the IMA950 multipeptide vaccine adjuvanted with poly-ICLC in HLA-A2 + glioma patients.

Methods: Adult patients with newly diagnosed glioblastoma (n=16) and grade III astrocytoma (n=3) were treated with radiochemotherapy followed by IMA950/poly-ICLC vaccination. Read More

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http://dx.doi.org/10.1093/neuonc/noz040DOI Listing
February 2019
12 Reads
5.562 Impact Factor

Hemorrhagic presentation of frontal partially calcified pilocytic astrocytoma in an 18-year-old woman: A case report and literature review as "clinical case".

Neurochirurgie 2019 Feb 30;65(1):32-35. Epub 2019 Jan 30.

Department of radiology, Assistance publique-Hôpitaux de Paris, Bichat Hospital, 46, rue Henri-Huchard, 75018, Paris, France; INSERM U1148, 75018 Paris, France; University Paris 7, Faculté de Médecine Xavier-Bichat, 75018 Paris, France. Electronic address:

We report an unusual case of a frontal partially calcified pilocytic astrocytoma (PA) (WHO grade 1) in an 18-year-old woman who presented with acute, spontaneous intracerebral hemorrhage. Histopathology revealed the PA was mixed with psammoma bodies and areas of vascular proliferation responsible for a hypervascular pattern. The patient underwent a total gross resection. Read More

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http://dx.doi.org/10.1016/j.neuchi.2018.12.002DOI Listing
February 2019

Outcomes Following Proton Therapy for Pediatric Low-Grade Glioma.

Int J Radiat Oncol Biol Phys 2019 May 23;104(1):149-156. Epub 2019 Jan 23.

Department of Radiation Oncology, University of Florida College of Medicine, Jacksonville, Florida.

Purpose: Dosimetric studies show that proton therapy can reduce the low/intermediate radiation dose to uninvolved tissue in children with low-grade glioma (LGG). For this reason, LGG is the fourth most common pediatric tumor treated with proton therapy, yet clinical outcome data on efficacy and toxicity are limited.

Methods And Materials: We reviewed the medical records of 174 children (≤21 years old) with nonmetastatic LGG enrolled on a prospective protocol and treated with proton therapy between 2007 and 2017. Read More

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http://dx.doi.org/10.1016/j.ijrobp.2019.01.078DOI Listing
May 2019
26 Reads

Influence of molecular classification in anaplastic glioma for determining outcome and future approach to management.

J Med Imaging Radiat Oncol 2019 Apr 24;63(2):272-280. Epub 2019 Jan 24.

Northern Sydney Cancer Centre, Royal North Shore Hospital, Sydney, New South Wales, Australia.

Introduction: Assess survival of patients with anaplastic glioma (AG) and the relationship to molecular subtype.

Methods: Patients with AG managed with IMRT between 2008 and 2014 were entered into a prospective database assessing relapse-free survival (RFS) and overall survival (OS). Isocitrate dehydrogenase (IDH) mutations were assessed prospectively from 2011, and subsequent testing of historical patients allowing categorisation under WHO 2016 classification as anaplastic astrocytoma IDH wild type (AAwt), anaplastic astrocytoma IDH mutated (AAmut), anaplastic oligodendroglioma (AOD) or other glial tumour (OTH). Read More

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http://dx.doi.org/10.1111/1754-9485.12850DOI Listing
April 2019
4 Reads

Reliability of Imaging-Based Diagnosis of Lateral Ventricular Masses in Children.

World Neurosurg 2019 Jan 17. Epub 2019 Jan 17.

Department of Neurological Sciences, Christian Medical College and Hospital, Vellore, Tamil Nadu, India. Electronic address:

Objective: We studied the accuracy of the radiologic diagnosis of lateral ventricular masses in children (<20 years of age).

Methods: In this retrospective study, data were collected from children with lateral ventricular masses managed in our unit between 2001 and 2016. There were 43 patients (26 boys and 17 girls; mean age, 12. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S18788750193007
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http://dx.doi.org/10.1016/j.wneu.2018.12.196DOI Listing
January 2019
14 Reads

MITK-ModelFit: A generic open-source framework for model fits and their exploration in medical imaging - design, implementation and application on the example of DCE-MRI.

BMC Bioinformatics 2019 Jan 16;20(1):31. Epub 2019 Jan 16.

Division of Medical Image Computing, German Cancer Research Center DKFZ, Heidelberg, Germany.

Background: Many medical imaging techniques utilize fitting approaches for quantitative parameter estimation and analysis. Common examples are pharmacokinetic modeling in dynamic contrast-enhanced (DCE) magnetic resonance imaging (MRI)/computed tomography (CT), apparent diffusion coefficient calculations and intravoxel incoherent motion modeling in diffusion-weighted MRI and Z-spectra analysis in chemical exchange saturation transfer MRI. Most available software tools are limited to a special purpose and do not allow for own developments and extensions. Read More

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https://bmcbioinformatics.biomedcentral.com/articles/10.1186
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http://dx.doi.org/10.1186/s12859-018-2588-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6335810PMC
January 2019
13 Reads

MR imaging features of spinal pilocytic astrocytoma.

BMC Med Imaging 2019 01 14;19(1). Epub 2019 Jan 14.

Department of Radiology, Huashan Hospital, Fudan University, 12 Middle Wulumuqi Road, Jingan District, Shanghai, China.

Background: The purpose of this retrospective review is to determine the MR imaging features of pilocytic astrocytoma (PA) in the spinal cord to help neuroradiologists preoperatively differentiate PA from other intramedullary tumors.

Methods: Neuro-oncology database review revealed 13 consecutive patients with a pathological spinal PA diagnosis and availability of preoperative MR imaging. Three patients had preoperative diffusion-weighted MR imaging. Read More

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http://dx.doi.org/10.1186/s12880-018-0296-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6332544PMC
January 2019
2 Reads

Papillary glioblastoma exhibiting a neuroradiological cyst with a mural nodule: A case report.

Medicine (Baltimore) 2019 Jan;98(2):e14102

Division of Human Pathology, Department of Pathology and Microbiology.

Rationale: Glioblastomas are malignant, infiltrating gliomas classified as grade IV by the World Health Organization. Genetically, most glioblastomas do not exhibit the isocitrate dehydrogenase (IDH) 1/2 gene mutation and rarely harbor the 1p/19q co-deletion. Neuroradiologically, glioblastomas rarely form a cyst with a mural nodule lesion. Read More

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http://Insights.ovid.com/crossref?an=00005792-201901110-0007
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http://dx.doi.org/10.1097/MD.0000000000014102DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6336597PMC
January 2019
3 Reads

Tissue-type mapping of gliomas.

Neuroimage Clin 2019 25;21:101648. Epub 2018 Dec 25.

Neurosciences Research Centre, Molecular and Clinical Sciences Research Institute, St. George's, University of London, Cranmer Terrace, London SW17 0RE, UK. Electronic address:

Purpose: To develop a statistical method of combining multimodal MRI (mMRI) of adult glial brain tumours to generate tissue heterogeneity maps that indicate tumour grade and infiltration margins.

Materials And Methods: We performed a retrospective analysis of mMRI from patients with histological diagnosis of glioma (n = 25). H Magnetic Resonance Spectroscopic Imaging (MRSI) was used to label regions of "pure" low- or high-grade tumour across image types. Read More

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http://dx.doi.org/10.1016/j.nicl.2018.101648DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6411966PMC
December 2018
2 Reads

The role of diffusion and perfusion magnetic resonance imaging in differentiation of haemangioblastomas and pilocytic astrocytomas.

Pol J Radiol 2018 10;83:e197-e203. Epub 2018 May 10.

Department of General and Interventional Radiology and Neuroradiology, Wroclaw Medical University, Poland.

Purpose: Haemangioblastomas (HABLs) and pilocytic astrocytomas (PAs) are brain tumours presenting similar appearance and location in conventional magnetic resonance (MR) imaging. The purpose of our study was to determine whether a detailed analysis of diffusion (DWI) and perfusion (PWI) characteristics can be useful in preoperative differentiation of these tumours.

Material And Methods: The study group consisted of biopsy proven six HABLs and six PAs, which underwent preoperative standard MR examinations including PWI and DWI. Read More

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https://www.termedia.pl/doi/10.5114/pjr.2018.75870
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http://dx.doi.org/10.5114/pjr.2018.75870DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6323599PMC
May 2018
7 Reads

Ganglioglioma Arising from the Septum Pellucidum: Case Report and Review of the Literature.

Pediatr Neurosurg 2019 8;54(1):36-45. Epub 2019 Jan 8.

Department of Neurological Surgery, University of Virginia Health Science Center, University of Virginia, Charlottesville, Virginia, USA,

Background: Gangliogliomas are low-grade neoplasms that typically affect patients under the age of 30 and present with epilepsy and symptoms of mass effect. Here, we report a case of an intraventricular ganglioglioma involving the septum pellucidum in a pediatric patient with history of optic glioma. Only one other pediatric intraventricular ganglioglioma arising from the septum pellucidum has been reported previously. Read More

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https://www.karger.com/Article/FullText/495043
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http://dx.doi.org/10.1159/000495043DOI Listing
January 2019
18 Reads
0.497 Impact Factor

Texture analysis on conventional MRI images accurately predicts early malignant transformation of low-grade gliomas.

Eur Radiol 2019 Jan 7. Epub 2019 Jan 7.

Department of Radiology, Weill Cornell Medicine, 407 E 61st Street Suite 107, New York, NY, 10065, USA.

Objectives: Texture analysis performed on MRI images can provide additional quantitative information that is invisible to human assessment. This study aimed to evaluate the feasibility of texture analysis on preoperative conventional MRI images in predicting early malignant transformation from low- to high-grade glioma and compare its utility to histogram analysis alone.

Methods: A total of 68 patients with low-grade glioma (LGG) were included in this study, 15 of which showed malignant transformation. Read More

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http://dx.doi.org/10.1007/s00330-018-5921-1DOI Listing
January 2019
4 Reads

FCNN-based axon segmentation for convection-enhanced delivery optimization.

Int J Comput Assist Radiol Surg 2019 Mar 7;14(3):493-499. Epub 2019 Jan 7.

Department of Advanced Robotics (ADVR), Istituto Italiano di Tecnologia, Via Morego 30, 16136, Genoa, GE, Italy.

Purpose: Glioblastoma multiforme treatment is a challenging task in clinical oncology. Convection- enhanced delivery (CED) is showing encouraging but still suboptimal results due to drug leakages. Numerical models can predict drug distribution within the brain, but require retrieving brain physical properties, such as the axon diameter distribution (ADD), through axon architecture analysis. Read More

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http://dx.doi.org/10.1007/s11548-018-01911-zDOI Listing
March 2019
1 Read

Conventionally fractionated stereotactic radiotherapy (CFRT) in combination with dose-dense temozolomide (TMZ) in relapsed malignant glioma: A case report.

Medicine (Baltimore) 2019 Jan;98(1):e13869

Department of Radiation Oncology, Affiliated Hospital of Hebei University, Baoding, Hebei, P.R. China.

Rationale: At present, there is no uniform consensus on the treatment of recurrent glioblastoma, especially the re-irradiation dose and temozolomide (TMZ) dose. The literature on the treatment of recurrent glioblastoma (GBM) by conventionally fractionated stereotactic radiotherapy (CFRT) is even rarer.

Patient Concerns: A 44-year-old woman was admitted to our hospital for residual tumor after reoperation. Read More

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http://dx.doi.org/10.1097/MD.0000000000013869DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6344191PMC
January 2019
3 Reads

Relapsing Tumefactive Demyelination: A Case Report.

Acta Med Acad 2018 Nov;47(2):193-198

Neurology Clinic, Clinical Center of Sarajevo University, Sarajevo, Bosnia and Herzegovina.

Objective: We present a case of relapsing tumefactive demyelination in a young female patient, that posed a real diagnostic challenge, with a heterogeneous clinical picture, atypical for multiple sclerosis (MS) presentation, and neuroradiological manifestations with a high suspicion of neoplastic diseases.

Case Report: An 18-year old female patient presented to our Neurosurgical Out-patients' Clinic with symptoms atypical for multiple sclerosis, unremarkable neurological deficit, one tumefactive lesion on MRI, followed by relapse and another two lesions within a period of six months. We decided to perform biopsy of the tumefactive lesion with compressive effect. Read More

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http://dx.doi.org/10.5644/ama2006-124.231DOI Listing
November 2018

Manifestation of a solitary retinal astrocytic hamartoma in a patient with Best macular dystrophy.

Am J Ophthalmol Case Rep 2019 Mar 11;13:80-82. Epub 2018 Dec 11.

Casey Eye Institute at Oregon Health & Science University, United States.

Purpose: To report the case of an adolescent male with a history of Best macular dystrophy and retinal astrocytic hamartoma.

Observations: A 15 year old male with a history of Best macular dystrophy who had been followed by ophthalmology for 9 years was noted to have progressive enlargement of a superonasal peripapillary retinal lesion. Imaging and exam are consistent with a diagnosis of retinal astrocytic hamartoma. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S24519936183033
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http://dx.doi.org/10.1016/j.ajoc.2018.12.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6299127PMC
March 2019
11 Reads

Repeat Bleeding 18 Years After Hemorrhagic Pilocytic Astrocytoma: Prognostic Implications of Conservative Management-Case Report and Literature Review.

World Neurosurg 2019 Mar 19;123:328-338. Epub 2018 Dec 19.

Department of Neurosurgery, Policlinico "Tor Vergata", University of Rome "Tor Vergata", Rome, Italy.

Background: Acute hemorrhagic occurrence of pilocytic astrocytomas is extremely rare but has become increasingly recognized and often presents in clinically emergent situations. The precise significance of hemorrhage in these tumors and its pathogenetic mechanisms have not yet been defined. Nothing is known about the natural history of bleeding pilocytic astrocytomas. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S18788750183285
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http://dx.doi.org/10.1016/j.wneu.2018.12.032DOI Listing
March 2019
8 Reads

Successful treatment with temozolomide in an elderly woman with advanced pulmonary large-cell neuroendocrine carcinoma: A case report.

Medicine (Baltimore) 2018 Dec;97(51):e13318

Department of Medical Oncology.

Rationale: Pulmonary large-cell neuroendocrine carcinoma (LCNEC) is a rare type of lung cancer, and 40% of patients are in stage IV at initial diagnosis. It has an extremely poor prognosis with a 1-year survival rate of 27%. Patients with LCNEC are predominantly male, older, and heavy smokers. Read More

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http://Insights.ovid.com/crossref?an=00005792-201812210-0001
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http://dx.doi.org/10.1097/MD.0000000000013318DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6320007PMC
December 2018
3 Reads

[Diffuse Astrocytoma with Pilomyxoid Features Presenting as Intratumoral Hemorrhage:A Case Report].

No Shinkei Geka 2018 Dec;46(12):1073-1079

Department of Neurosurgery(Omori), School of Medicine, Faculty of Medicine, Toho University.

Hemorrhagic low-grade glioma(LGG)without malignant transformation is rare, accounting for less than 1% of cases. To the best of our knowledge, hemorrhagic LGG with an arteriovenous(AV)shunt has not been reported. We report the case of 17-year-old man with LGG with an AV shunt. Read More

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http://dx.doi.org/10.11477/mf.1436203870DOI Listing
December 2018
21 Reads

Brainstem astrocytoma as a neuro-Behçet's disease mimic.

BMJ Case Rep 2018 Dec 7;11(1). Epub 2018 Dec 7.

Internal Medicine, Division of Rheumatology, New York University, New York City, New York, USA.

A 58-year-old man with a history of recurrent aphthous ulcers since childhood was admitted to the hospital with acute neurological decline characterised by loss of motor dexterity, dysarthria, dysphagia and unsteady gait. MRI brain was significant for symmetrical hyperintense T2 fluid attenuated inversion recovery (FLAIR) in the corticospinal tracts, including parts of the pons and the mesodiencephalic junction. Though initial concern was for neuro-Behçet's disease, brain biopsy ultimately revealed a diagnosis of astrocytoma. Read More

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http://dx.doi.org/10.1136/bcr-2018-226945DOI Listing
December 2018

Magnetic resonance imaging-guided radiation therapy using animal models of glioblastoma.

Br J Radiol 2019 Mar 17;92(1095):20180713. Epub 2019 Jan 17.

2 Department of Nuclear Medicine, Ghent University Hospital , Ghent , Belgium.

Glioblastoma is the most aggressive and most common malignant primary brain tumour in adults and has a high mortality and morbidity. Because local tumour control in glioblastoma patients is still elusive in the majority of patients, there is an urgent need for alternative treatment strategies. However, to implement changes to the existing clinical standard of care, research must be conducted to develop alternative treatment strategies. Read More

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https://www.birpublications.org/doi/10.1259/bjr.20180713
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http://dx.doi.org/10.1259/bjr.20180713DOI Listing
March 2019
11 Reads

Comparisons Between PET With 11C-Methyl-L-Methionine and Arterial Spin Labeling Perfusion Imaging in Recurrent Glioblastomas Treated With Bevacizumab.

Clin Nucl Med 2019 Mar;44(3):186-193

From the Department of Neurosurgery.

Purpose: The aim of this study was to clarify whether arterial spin labeling (ASL) perfusion imaging can assess biological effects from bevacizumab (BEV) therapy as reliably as PET with C-methyl-L-methionine (C-met-PET).

Materials And Methods: Twenty-four patients with recurrent glioblastoma were examined using both ASL and C-met-PET before and 4 and 8 weeks after starting BEV treatment. Tumor-to-normal brain (T/N) ratios, fluctuations in T/N ratio, and tumor volumes were compared between ASL and C-met-PET. Read More

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http://dx.doi.org/10.1097/RLU.0000000000002417DOI Listing
March 2019
1 Read

Intraventricular Pilocytic Astrocytoma With KIAA1549/BRAF Fusion Arising in a 44-Year Old.

J Neuropathol Exp Neurol 2019 Feb;78(2):187-190

Department of Pathology, Duke University, Durham, North Carolina.

Rare pilocytic astrocytomas (PA) have been described to arise in the ventricles of children. They are even less common in this location for the adult population. We present the case of a 44-year old man presenting with vision and mental status changes. Read More

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http://dx.doi.org/10.1093/jnen/nly116DOI Listing
February 2019
3 Reads

Tanycytic ependymoma of filum terminale: Clinical characteristics and surgical outcomes.

Oncol Lett 2018 Dec 1;16(6):6910-6917. Epub 2018 Oct 1.

Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing 100050, P.R. China.

Tanycytic ependymoma (TE), a rare subtype of ependymoma, was classified as grade II ependymoma by the World Health Organization in 2000 and 2007. Preoperative diagnosis of TE is challenging due to its similarities to schwannoma and astrocytoma; therefore, differentiation is required. The present study investigated the clinical, imaging and pathological characteristics of TE in the filum terminale. Read More

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http://www.spandidos-publications.com/10.3892/ol.2018.9531
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http://dx.doi.org/10.3892/ol.2018.9531DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6256739PMC
December 2018
10 Reads

Unsupervised pathology detection in medical images using conditional variational autoencoders.

Int J Comput Assist Radiol Surg 2019 Mar 12;14(3):451-461. Epub 2018 Dec 12.

Institute of Medical Informatics, University of Lübeck, Lübeck, Germany.

Purpose: Pathology detection in medical image data is an important but a rather complicated task. In particular, the big variability of the pathologies is a challenge to automatic detection methods and even to machine learning methods. Supervised algorithms would usually learn the appearance of a single pathological structure based on a large annotated dataset. Read More

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http://dx.doi.org/10.1007/s11548-018-1898-0DOI Listing
March 2019
1 Read

Radiographic assessment of contrast enhancement and T2/FLAIR mismatch sign in lower grade gliomas: correlation with molecular groups.

J Neurooncol 2019 Jan 7;141(2):327-335. Epub 2018 Dec 7.

Translational Neuro-Oncology Laboratory, Department of Neurosurgery, Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA, USA.

Purpose: With the updated World Health Organization (WHO) 2016 neuropathological diagnostic criteria, radiographic prognostic associations in lower-grade gliomas (LGG, WHO grade II and III) are undergoing re-evaluation.

Methods: We identified 316 LGG patients (151 grade II and 165 grade III) for a combined cohort from three independent databases. We analyzed the preoperative axial FLAIR, axial T2-weighted and post-gadolinium volumetric T1-weighted MR images. Read More

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http://dx.doi.org/10.1007/s11060-018-03034-6DOI Listing
January 2019
1 Read

Opening the Blood-Brain Barrier and Improving the Efficacy of Temozolomide Treatments of Glioblastoma Using Pulsed, Focused Ultrasound with a Microbubble Contrast Agent.

Biomed Res Int 2018 11;2018:6501508. Epub 2018 Nov 11.

Department of Cardiovascular Medicine, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.

Objective: To explore the effects of pulsed, focused, and microbubble contrast agent-enhanced ultrasonography (mCEUS) on blood-brain barrier (BBB) permeability and the efficacy temozolomide for glioblastoma.

Methods: Wistar rats (n = 30) were divided into three groups (n = 10 per group) to determine optimal CUES conditions for achieving BBB permeability, as assessed by ultrastructure transmission electron microscopy (TEM) and western blot assays for the tight junction protein claudin-5. Optimized mCEUS effects on BBB permeability were subsequently confirmed with Evans blue staining (2 groups of 10 rats). Read More

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http://dx.doi.org/10.1155/2018/6501508DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6252217PMC
March 2019
1 Read

Grading and proliferation assessment of diffuse astrocytic tumors with monoexponential, biexponential, and stretched-exponential diffusion-weighted imaging and diffusion kurtosis imaging.

Eur J Radiol 2018 Dec 5;109:188-195. Epub 2018 Nov 5.

Department of Radiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China. Electronic address:

Purpose: To compare the main parameters derived from monoexponential, biexponential and stretched-exponential diffusion-weighted imaging (DWI) and diffusion kurtosis imaging (DKI) with respect to diagnostic performance for tumor grading and proliferation assessment in diffuse astrocytic tumors (DATs).

Materials And Methods: Fifty-eight pathologically confirmed DAT patients who underwent DWI and DKI on a 3-T scanner were prospectively collected and retrospectively reviewed. Measurements including the apparent diffusion coefficient (ADC), true diffusion coefficient (D), pseudodiffusion coefficient (D), perfusion fraction (f), distributed diffusion coefficient (DDC), heterogeneity index (α), mean diffusivity (MD), fractional anisotropy (FA), and mean kurtosis (MK) were compared between tumor grades (Ⅱ, Ⅲ, and Ⅳ) by using a Jonckheere-Terpstra test. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0720048X183039
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http://dx.doi.org/10.1016/j.ejrad.2018.11.003DOI Listing
December 2018
13 Reads