11,055 results match your criteria Imaging in Juvenile Pilocytic Astrocytoma

A curious case of T2-FLAIR mismatch in H3K27M mutant glioma.

Radiol Case Rep 2022 Sep 17;17(9):2930-2935. Epub 2022 Jun 17.

Riverside Community Hospital, 4445 Magnolia Avenue, Riverside, CA, 92501 USA.

Diffuse midline gliomas are a rare relatively new classification of primary central nervous system tumors which include astrocytomas, oligodendrogliomas, and glioblastomas. The T2-FLAIR mismatch sign is regarded as a highly specific imaging feature of IDH-mutant, 1p/19q non-codeleted astrocytomas. The case presented herein demonstrates this sign, however, in a non-IDH mutated diffuse midline glioma with a H3K27M mutation, a World Health Organization Grade IV neoplasm. Read More

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September 2022

Ellipsoid calculations versus manual tumor delineations for glioblastoma tumor volume evaluation.

Sci Rep 2022 Jun 22;12(1):10502. Epub 2022 Jun 22.

Department of Radiotherapy, ICANS, Institut Cancérologie Strasbourg Europe, 17 Rue Albert Calmette, 67200, Strasbourg Cedex, France.

In glioblastoma, the response to treatment assessment is essentially based on the 2D tumor size evolution but remains disputable. Volumetric approaches were evaluated for a more accurate estimation of tumor size. This study included 57 patients and compared two volume measurement methods to determine the size of different glioblastoma regions of interest: the contrast-enhancing area, the necrotic area, the gross target volume and the volume of the edema area. Read More

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Recent development of contrast agents for magnetic resonance and multimodal imaging of glioblastoma.

J Nanobiotechnology 2022 Jun 16;20(1):284. Epub 2022 Jun 16.

School of Science and Shenzhen Key Laboratory of Flexible Printed Electronics Technology, Harbin Institute of Technology, Shenzhen, 518055, China.

Glioblastoma (GBM) as the most common primary malignant brain tumor exhibits a high incidence and degree of malignancy as well as poor prognosis. Due to the existence of formidable blood-brain barrier (BBB) and the aggressive growth and infiltrating nature of GBM, timely diagnosis and treatment of GBM is still very challenging. Among different imaging modalities, magnetic resonance imaging (MRI) with merits including high soft tissue resolution, non-invasiveness and non-limited penetration depth has become the preferred tool for GBM diagnosis. Read More

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Progression Patterns in Non-Contrast-Enhancing Gliomas Support Brain Tumor Responsiveness to Surgical Lesions.

Pathol Oncol Res 2022 30;28:1610268. Epub 2022 May 30.

Department of Neurosurgery, University Hospital Mannheim, University of Heidelberg, Mannheim, Germany.

The overall benefit of surgical treatments for patients with glioma is undisputed. We have shown preclinically that brain tumor cells form a network that is capable of detecting damage to the tumor, and repair itself. The aim of this study was to determine whether a similar mechanism might contribute to local recurrence in the clinical setting. Read More

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Spatially resolved multi-omics deciphers bidirectional tumor-host interdependence in glioblastoma.

Cancer Cell 2022 Jun;40(6):639-655.e13

Faculty of Medicine, University of Freiburg, Freiburg, Germany; Department of Medicine II: Gastroenterology, Hepatology, Endocrinology, and Infectious Disease, Medical Center - University of Freiburg, Freiburg, Germany.

Glioblastomas are malignant tumors of the central nervous system hallmarked by subclonal diversity and dynamic adaptation amid developmental hierarchies. The source of dynamic reorganization within the spatial context of these tumors remains elusive. Here, we characterized glioblastomas by spatially resolved transcriptomics, metabolomics, and proteomics. Read More

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MRI-based whole-tumor radiomics to classify the types of pediatric posterior fossa brain tumor.

Neurochirurgie 2022 Jun 3. Epub 2022 Jun 3.

Institute of Cancer & Genomic Science, University of Birmingham, B152TT, Birmingham, United Kingdom.

Background: Differential diagnosis between medulloblastoma (MB), ependymoma (EP) and astrocytoma (PA) is important due to differing medical treatment strategies and predicted survival. The aim of this study was to investigate non-invasive MRI-based radiomic analysis of whole tumors to classify the histologic tumor types of pediatric posterior fossa brain tumor and improve the accuracy of discrimination, using a random forest classifier.

Methods: MRI images of 99 patients, with 59 MBs, 13 EPs and 27 PAs histologically confirmed by surgery and pathology before treatment, were included in this retrospective study. Read More

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DNA-methylome-assisted classification of patients with poor prognostic subventricular zone associated IDH-wildtype glioblastoma.

Acta Neuropathol 2022 Jul 4;144(1):129-142. Epub 2022 Jun 4.

German Cancer Consortium (DKTK), Core Center Heidelberg, Heidelberg, Germany.

Glioblastoma (GBM) derived from the "stem cell" rich subventricular zone (SVZ) may constitute a therapy-refractory subgroup of tumors associated with poor prognosis. Risk stratification for these cases is necessary but is curtailed by error prone imaging-based evaluation. Therefore, we aimed to establish a robust DNA methylome-based classification of SVZ GBM and subsequently decipher underlying molecular characteristics. Read More

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Quantitative relaxometry using synthetic MRI could be better than T2-FLAIR mismatch sign for differentiation of IDH-mutant gliomas: a pilot study.

Sci Rep 2022 Jun 2;12(1):9197. Epub 2022 Jun 2.

Department of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.

This study aimed to determine whether quantitative relaxometry using synthetic magnetic resonance imaging (SyMRI) could differentiate between two diffuse glioma groups with isocitrate dehydrogenase (IDH)-mutant tumors, achieving an increased sensitivity compared to the qualitative T2-fluid-attenuated inversion recovery (FLAIR) mismatch sign. Between May 2019 and May 2020, thirteen patients with IDH-mutant diffuse gliomas, including seven with astrocytomas and six with oligodendrogliomas, were evaluated. Five neuroradiologists independently evaluated the presence of the qualitative T2-FLAIR mismatch sign. Read More

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Application of blood brain barrier models in pre-clinical assessment of glioblastoma-targeting CAR-T based immunotherapies.

Fluids Barriers CNS 2022 Jun 1;19(1):38. Epub 2022 Jun 1.

Human Health Therapeutics Research Centre, National Research Council of Canada, Building M-54, Montreal Road, ON, K1A 0R6, Ottawa, Canada.

Human blood brain barrier (BBB) models derived from induced pluripotent stem cells (iPSCs) have become an important tool for the discovery and preclinical evaluation of central nervous system (CNS) targeting cell and gene-based therapies. Chimeric antigen receptor (CAR)-T cell therapy is a revolutionary form of gene-modified cell-based immunotherapy with potential for targeting solid tumors, such as glioblastomas. Crossing the BBB is an important step in the systemic application of CAR-T therapy for the treatment of glioblastomas and other CNS malignancies. Read More

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Discrimination between glioblastoma and solitary brain metastasis: a quantitative analysis based on FLAIR signal intensity.

Eur Rev Med Pharmacol Sci 2022 May;26(10):3577-3584

Department of Radiology, Hanoi Medical University, Hanoi, Vietnam.

Objective: This study determined the diagnostic performance of fluid-attenuated inversion recovery (FLAIR) signal intensity (SI) in discriminating between glioblastoma (GBM) and solitary brain metastasis (SBM).

Patients And Methods: We recruited 40 patients with a histologically confirmed diagnosis of GBM or SBM who underwent conventional 3 Tesla magnetic resonance imaging before surgery or biopsy between August 2020 and January 2022. Three regions of interest were placed to assess FLAIR SI: the enhancing region (eFLAIR), the peritumoral region (pFLAIR), and the contralateral normal white matter (nFLAIR). Read More

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Grading of IDH-mutant astrocytoma using diffusion, susceptibility and perfusion-weighted imaging.

BMC Med Imaging 2022 May 29;22(1):105. Epub 2022 May 29.

Department of Radiology, First Affiliated Hospital of Fujian Medical University, 20 Cha-Zhong Road, Fuzhou, 350005, Fujian, People's Republic of China.

Background: The accurate grading of IDH-mutant astrocytoma is essential to make therapeutic strategies and assess the prognosis of patients. The purpose of this study was to investigate the usefulness of DWI, SWI and DSC-PWI in grading IDH-mutant astrocytoma.

Methods: One hundred and seven patients with IDH-mutant astrocytoma who underwent DWI, SWI and DSC-PWI were retrospectively reviewed. Read More

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Endoscope-Assisted Extreme Lateral Supracerebellar Infratentorial Approach for Resection of Superior Cerebellar Peduncle Pilocytic Astrocytoma: Technical Note.

Children (Basel) 2022 Apr 29;9(5). Epub 2022 Apr 29.

Department of Neurosurgery, University Hospital of Lausanne and University of Lausanne, 1015 Lausanne, Switzerland.

(1) Background: Superior cerebellar peduncle (SCP) lesions are sparsely reported in the literature. The surgical approaches to the cerebello-mesencephalic region remain challenging. In this article, we present the extreme lateral supracerebellar infratentorial (ELSI) approach to treat a large hemorrhagic pilocytic astrocytoma of the SCP. Read More

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Application of 7T MRS to High-Grade Gliomas.

AJNR Am J Neuroradiol 2022 May 26. Epub 2022 May 26.

From the Department of Neurosurgery (L.M., C.G.H.), Icahn School of Medicine at Mount Sinai, Mount Sinai Health System, New York, New York.

MRS, including single-voxel spectroscopy and MR spectroscopic imaging, captures metabolites in high-grade gliomas. Emerging evidence indicates that 7T MRS may be more sensitive to aberrant metabolic activity than lower-field strength MRS. However, the literature on the use of 7T MRS to visualize high-grade gliomas has not been summarized. Read More

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Novel therapeutics and drug-delivery approaches in the modulation of glioblastoma stem cell resistance.

Ther Deliv 2022 04 26;13(4):249-273. Epub 2022 May 26.

Department of Radiology & Imaging Sciences, Indiana University School of Medicine, Indianapolis, IN 46202, USA.

Glioblastoma (GBM) is a deadly malignancy with a poor prognosis. An important factor contributing to GBM recurrence is high resistance of GBM cancer stem cells (GSCs). While temozolomide (TMZ), has been shown to consistently extend survival, GSCs grow resistant to TMZ through upregulation of DNA damage repair mechanisms and avoidance of apoptosis. Read More

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Analysis of the Prognosis of High-Grade gliomas in the View of New Immunohistochemistry Markers and 2016 WHO Classification.

Turk Neurosurg 2022 ;32(3):500-507

Istanbul University, Istanbul Faculty of Medicine, Department of Neurosurgery, Istanbul, Turkey.

Aim: To evaluate isocitrate dehydrogenase (IDH) mutation status and Ki67 percentages of tumors that were treated in our institution to determine whether these markers affected the initial diagnosis and survival rates.

Material And Methods: High-grade glioma patients, who were operated in our department between 2013 and 2018, were enrolled in the study and retrospectively reviewed. New immunohistochemistry staining studies were conducted and survival analyses were performed. Read More

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Multifocal Desmoplastic Infantile Ganglioglioma/Astrocytoma (DIA/DIG): An Institutional Series Report and a Clinical Summary of This Rare Tumor.

Front Oncol 2021 9;11:608129. Epub 2022 May 9.

School of Computer Science and Engineering, University of Electronic Science and Technology of China, Chengdu, China.

Aim: Multifocal desmoplastic infantile ganglioglioma/astrocytoma (DIA/DIG) has rarely been reported. Here, two cases have been presented, reviewing the literature and proposed treatment algorithms for this rare tumor.

Patients And Methods: We report two patients diagnosed with multifocal DIA/DIGs in West China Hospital. Read More

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Combining radiomics and deep convolutional neural network features from preoperative MRI for predicting clinically relevant genetic biomarkers in glioblastoma.

Neurooncol Adv 2022 Jan-Dec;4(1):vdac060. Epub 2022 Apr 22.

Department of Radiology and Biomedical Imaging, University of California at San Francisco, San Francisco, California, USA.

Background: Glioblastoma is the most common primary brain malignancy, yet treatment options are limited, and prognosis remains guarded. Individualized tumor genetic assessment has become important for accurate prognosis and for guiding emerging targeted therapies. However, challenges remain for widespread tumor genetic testing due to costs and the need for tissue sampling. Read More

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Clinical measures, radiomics, and genomics offer synergistic value in AI-based prediction of overall survival in patients with glioblastoma.

Sci Rep 2022 May 24;12(1):8784. Epub 2022 May 24.

Center for Biomedical Image Computing and Analytics (CBICA), University of Pennsylvania, 3700 Hamilton Walk, 7th floor, Philadelphia, PA, 19104, USA.

Multi-omic data, i.e., clinical measures, radiomic, and genetic data, capture multi-faceted tumor characteristics, contributing to a comprehensive patient risk assessment. Read More

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Tracking glioblastoma progression after initial resection with minimal reaction-diffusion models.

Math Biosci Eng 2022 Mar;19(6):5446-5481

School of Mathematical & Statistical Sciences, Arizona State University, Tempe, AZ 85281, USA.

We describe a preliminary effort to model the growth and progression of glioblastoma multiforme, an aggressive form of primary brain cancer, in patients undergoing treatment for recurrence of tumor following initial surgery and chemoradiation. Two reaction-diffusion models are used: the Fisher-Kolmogorov equation and a 2-population model, developed by the authors, that divides the tumor into actively proliferating and quiescent (or necrotic) cells. The models are simulated on 3-dimensional brain geometries derived from magnetic resonance imaging (MRI) scans provided by the Barrow Neurological Institute. Read More

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Target receptor identification and subsequent treatment of resected brain tumors with encapsulated and engineered allogeneic stem cells.

Nat Commun 2022 May 19;13(1):2810. Epub 2022 May 19.

Department of Medicinal Chemistry, College of Pharmacy University of Utah, Salt Lake City, UT, 84112, USA.

Cellular therapies offer a promising therapeutic strategy for the highly malignant brain tumor, glioblastoma (GBM). However, their clinical translation is limited by the lack of effective target identification and stringent testing in pre-clinical models that replicate standard treatment in GBM patients. In this study, we show the detection of cell surface death receptor (DR) target on CD146-enriched circulating tumor cells (CTC) captured from the blood of mice bearing GBM and patients diagnosed with GBM. Read More

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Diffuse glioma, not otherwise specified: imaging-based risk stratification achieves histomolecular-level prognostication.

Eur Radiol 2022 May 19. Epub 2022 May 19.

Department of Neurosurgery, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Republic of Korea.

Objectives: To determine whether imaging-based risk stratification enables prognostication in diffuse glioma, NOS (not otherwise specified).

Methods: Data from 220 patients classified as diffuse glioma, NOS, between January 2011 and December 2020 were retrospectively included. Two neuroradiologists analyzed pre-surgical CT and MRI to assign gliomas to the three imaging-based risk types considering well-known imaging phenotypes (e. Read More

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Optic Neuropathy Revealing Severe Superficial Siderosis in the Setting of Long-standing Low-grade Intracranial Neoplasm.

Neuroophthalmology 2022 2;46(3):171-177. Epub 2021 Aug 2.

Ophthalmology Department, Cliniques Universitaires Saint-Luc, Brussels, Belgium.

Two cases of optic neuropathy due to superficial siderosis (SS) are reported in two patients, aged 29 and 38 years, operated for intracranial neoplasms, the first one with a desmoplasic infantile ganglioglioma excised in 1991, and the other one with a pilocytic astrocytoma, operated on in 1997, 1998 and 2016. Both patients presented with progressive loss of visual acuity, as a result of bilateral optic nerve atrophy, as well as unsteadiness, ataxic gait and hearing loss. Magnetic resonance imaging (MRI) of the brain and spine, including gradient echo (GRE) T2-weighted acquisitions, revealed thin optic nerves and strong hypointensity with susceptibility artefacts corresponding to haemosiderin deposits within the meningeal layers of the spine, the infra- and supratentorial spaces of the brain and the peri-optic sheaths in both patients. Read More

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Towards real-time intraoperative tissue interrogation for REIMS-guided glioma surgery.

J Mass Spectrom Adv Clin Lab 2022 Apr 29;24:80-89. Epub 2022 Apr 29.

Maastricht MultiModal Molecular Imaging (M4I) Institute, Division of Imaging Mass Spectrometry, Maastricht University, 6229 ER Maastricht, The Netherlands.

Introduction: The main goal of brain tumour surgery is to maximize tumour resection while avoiding neurological deficits. Accurate characterization of tissue and delineation of resection margins are, therefore, essential to achieve optimal surgical results.

Objectives: The primary objective of this study was to develop and validate a mass spectrometry- based technique for the molecular characterization of high- and low-grade glioma tissue during surgery. Read More

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Impact of childhood cerebellar tumor surgery on cognition revealed by precuneus hyperconnectivity.

Neurooncol Adv 2022 Jan-Dec;4(1):vdac050. Epub 2022 Apr 13.

Department of Neurosurgery, Medical University of Vienna, Vienna, Austria.

Background: Childhood cerebellar pilocytic astrocytomas harbor excellent overall survival rates after surgical resection, but the patients may exhibit specific cognitive and behavioral problems. Functional MRI has catalyzed insights into brain functional systems and has already been linked with the neuropsychological performance. We aimed to exploit the question of whether resting-state functional MRI can be used as a biomarker for the cognitive outcome assessment of these patients. Read More

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Giant Pediatric Supratentorial Tumor: Clinical Feature and Surgical Strategy.

Front Pediatr 2022 26;10:870951. Epub 2022 Apr 26.

Department of Neurosurgery, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China.

Purpose: To analyze the clinical character of giant pediatric supratentorial tumor (GPST) and explore prognostic factors.

Materials And Methods: We analyzed the clinical data comprising of 35 cases of GPST from a single center between January 2015 and December 2020. The tumor volume was measured by 3D slicer software based on preoperative magnetic resonance imaging (MRI). Read More

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A Gambogic Acid-Loaded Delivery System Mediated by Ultrasound-Targeted Microbubble Destruction: A Promising Therapy Method for Malignant Cerebral Glioma.

Int J Nanomedicine 2022 3;17:2001-2017. Epub 2022 May 3.

Henan Key Laboratory of Medical Tissue Regeneration, School of Basic Medical Sciences, Xinxiang Medical University, Xinxiang, Henan, 453003, People's Republic of China.

Background: The blood-brain barrier (BBB) inhibits the delivery of macromolecular chemotherapeutic drugs to brain tumors, leading to low utilization rates and toxic side effects to surrounding tissues and organs. Ultrasonic targeted microbubble destruction (UTMD) technology can open the BBB, leading to a new type of drug delivery system with particular utility in glioma.

Purpose: We have developed a new type of drug-loaded microbubble complex based on poly(lactic-co-glycolic acid) (PLGA) that targets gambogic acid (GA) to the area of brain tumors through UTMD. Read More

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Cervical Lymph Node Metastasis in Glioblastoma Multiformae.

Neurol India 2022 Mar-Apr;70(2):836

Department of Pathology, Columbia Asia Hospital, Patiala, Punjab, India.

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Diffuse intrinsic pontine gliomas in adults: A retrospective study.

Neurol India 2022 Mar-Apr;70(2):584-590

Department of Neuropathology, National Institute of Mental Health and Neurosciences, Bangalore, Karnataka, India.

Background: Brainstem gliomas (BSG) constitutes very small proportion in adults brain tumors with pons as most common location. There is significant paucity in literature for adult diffuse intrinsic pontine gliomas (DIPG).

Objective: In this study, we attempt to review the outcomes of DIPG in single institute. Read More

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Carboxymethylcellulose biofunctionalized ternary quantum dots for subcellular-targeted brain cancer nanotheranostics.

Int J Biol Macromol 2022 Jun 2;210:530-544. Epub 2022 May 2.

Center of Nanoscience, Nanotechnology, and Innovation-CeNano(2)I, Federal University of Minas Gerais/UFMG, Belo Horizonte, MG, Brazil. Electronic address:

Among the most lethal forms of cancer, malignant brain tumors persist as one of the greatest challenges faced by oncologists, where nanotechnology-driven theranostics can play a critical role in developing novel polymer-based supramolecular nanoarchitectures with multifunctional and multi-modal characteristics to fight cancer. However, it is virtually a consensus that, besides the complexity of active delivering anticancer drugs by the nanocarriers to the tumor site, the current evaluation methods primarily relying on in vitro assays and in vivo animal models have been accounted for the low translational effectiveness to clinical applications. In this view, the chick chorioallantoic membrane (CAM) assay has been increasingly recognized as one of the best preclinical models to study the effects of anticancer drugs on the tumor microenvironment (TME). Read More

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Activity of Pemigatinib in Pilocytic Astrocytoma and Mutation.

JCO Precis Oncol 2022 04;6:e2100371

Department of Investigational Cancer Therapeutics, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX.

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