8,842 results match your criteria Imaging in Juvenile Pilocytic Astrocytoma


The benefit of surveillance imaging for paediatric cerebellar pilocytic astrocytoma.

Childs Nerv Syst 2019 Feb 15. Epub 2019 Feb 15.

Department of Paediatric Oncology, Alder Hey Children's Hospital, Eaton Road, Liverpool, L12 2AP, UK.

Objectives: Paediatric cerebellar pilocytic astrocytomas (PA) (WHO grade 1) are amongst the most common of childhood brain tumours and are generally amenable to resection, with surgery alone being curative in the majority of cases. There is, however, a lack of consensus regarding the frequency and duration of post-treatment MRI surveillance for these tumours. This is important, as follow-up imaging is a significant use of resources and often associated with patient and family anxiety. Read More

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http://dx.doi.org/10.1007/s00381-019-04078-3DOI Listing
February 2019

Atypical Presentation of Glioblastoma Multiforme.

Eur J Case Rep Intern Med 2018 27;5(9):000954. Epub 2018 Sep 27.

Neurology Department, Henry Ford Health System, Detroit, MI, USA.

Background: Glioblastoma multiforme (GBM) is a highly malignant glial tumour classified by the World Health Organization (WHO) as a stage IV astrocytoma. It varies in shape and size and can be cystic, vascular and necrotic. It often appears as a ring-enhancing lesion on magnetic resonance imaging (MRI). Read More

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http://dx.doi.org/10.12890/2018_000954DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346815PMC
September 2018

Phase I/II trial testing safety and immunogenicity of the multipeptide IMA950/poly-ICLC vaccine in newly diagnosed adult malignant astrocytoma patients.

Neuro Oncol 2019 Feb 12. Epub 2019 Feb 12.

Department of Oncology, Clinical Research Unit, Dr Dubois Ferrière Dinu Lipatti Research Foundation, Geneva University Hospital, Geneva, Switzerland.

Background: Peptide vaccines offer the opportunity to elicit glioma-specific T cells with tumor killing ability. Using antigens eluted from the surface of glioblastoma samples, we designed a phase I/II study to test safety and immunogenicity of the IMA950 multipeptide vaccine adjuvanted with poly-ICLC in HLA-A2 + glioma patients.

Methods: Adult patients with newly diagnosed glioblastoma (n=16) and grade III astrocytoma (n=3) were treated with radiochemotherapy followed by IMA950/poly-ICLC vaccination. Read More

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http://dx.doi.org/10.1093/neuonc/noz040DOI Listing
February 2019
1 Read
5.562 Impact Factor

Outcomes Following Proton Therapy for Pediatric Low-Grade Glioma.

Int J Radiat Oncol Biol Phys 2019 Jan 23. Epub 2019 Jan 23.

Department of Radiation Oncology, University of Florida College of Medicine, Jacksonville, FL.

Background/objectives: Dosimetric studies show that proton therapy can reduce the low/intermediate radiation dose to uninvolved tissue in children with low-grade glioma (LGG). For this reason, LGG is the 4th most common pediatric tumor treated with proton therapy, yet clinical outcome data on efficacy and toxicity are limited.

Design/methods: We reviewed the medical records of 174 children (≤21 years old) with non-metastatic LGG enrolled on a prospective protocol and treated with proton therapy between 2007 and 2017 to assess clinical outcomes and toxicity, and analyze patient, tumor, and treatment-related variables. Read More

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http://dx.doi.org/10.1016/j.ijrobp.2019.01.078DOI Listing
January 2019
15 Reads

Influence of molecular classification in anaplastic glioma for determining outcome and future approach to management.

J Med Imaging Radiat Oncol 2019 Jan 24. Epub 2019 Jan 24.

Northern Sydney Cancer Centre, Royal North Shore Hospital, Sydney, New South Wales, Australia.

Introduction: Assess survival of patients with anaplastic glioma (AG) and the relationship to molecular subtype.

Methods: Patients with AG managed with IMRT between 2008 and 2014 were entered into a prospective database assessing relapse-free survival (RFS) and overall survival (OS). Isocitrate dehydrogenase (IDH) mutations were assessed prospectively from 2011, and subsequent testing of historical patients allowing categorisation under WHO 2016 classification as anaplastic astrocytoma IDH wild type (AAwt), anaplastic astrocytoma IDH mutated (AAmut), anaplastic oligodendroglioma (AOD) or other glial tumour (OTH). Read More

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http://dx.doi.org/10.1111/1754-9485.12850DOI Listing
January 2019
2 Reads

Reliability of Imaging-Based Diagnosis of Lateral Ventricular Masses in Children.

World Neurosurg 2019 Jan 17. Epub 2019 Jan 17.

Department of Neurological Sciences, Christian Medical College and Hospital, Vellore, Tamil Nadu, India. Electronic address:

Objective: We studied the accuracy of the radiologic diagnosis of lateral ventricular masses in children (<20 years of age).

Methods: In this retrospective study, data were collected from children with lateral ventricular masses managed in our unit between 2001 and 2016. There were 43 patients (26 boys and 17 girls; mean age, 12. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S18788750193007
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http://dx.doi.org/10.1016/j.wneu.2018.12.196DOI Listing
January 2019
5 Reads

MITK-ModelFit: A generic open-source framework for model fits and their exploration in medical imaging - design, implementation and application on the example of DCE-MRI.

BMC Bioinformatics 2019 Jan 16;20(1):31. Epub 2019 Jan 16.

Division of Medical Image Computing, German Cancer Research Center DKFZ, Heidelberg, Germany.

Background: Many medical imaging techniques utilize fitting approaches for quantitative parameter estimation and analysis. Common examples are pharmacokinetic modeling in dynamic contrast-enhanced (DCE) magnetic resonance imaging (MRI)/computed tomography (CT), apparent diffusion coefficient calculations and intravoxel incoherent motion modeling in diffusion-weighted MRI and Z-spectra analysis in chemical exchange saturation transfer MRI. Most available software tools are limited to a special purpose and do not allow for own developments and extensions. Read More

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https://bmcbioinformatics.biomedcentral.com/articles/10.1186
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http://dx.doi.org/10.1186/s12859-018-2588-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6335810PMC
January 2019
6 Reads

MR imaging features of spinal pilocytic astrocytoma.

BMC Med Imaging 2019 Jan 14;19(1). Epub 2019 Jan 14.

Department of Radiology, Huashan Hospital, Fudan University, 12 Middle Wulumuqi Road, Jingan District, Shanghai, China.

Background: The purpose of this retrospective review is to determine the MR imaging features of pilocytic astrocytoma (PA) in the spinal cord to help neuroradiologists preoperatively differentiate PA from other intramedullary tumors.

Methods: Neuro-oncology database review revealed 13 consecutive patients with a pathological spinal PA diagnosis and availability of preoperative MR imaging. Three patients had preoperative diffusion-weighted MR imaging. Read More

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http://dx.doi.org/10.1186/s12880-018-0296-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6332544PMC
January 2019
1 Read

Papillary glioblastoma exhibiting a neuroradiological cyst with a mural nodule: A case report.

Medicine (Baltimore) 2019 Jan;98(2):e14102

Division of Human Pathology, Department of Pathology and Microbiology.

Rationale: Glioblastomas are malignant, infiltrating gliomas classified as grade IV by the World Health Organization. Genetically, most glioblastomas do not exhibit the isocitrate dehydrogenase (IDH) 1/2 gene mutation and rarely harbor the 1p/19q co-deletion. Neuroradiologically, glioblastomas rarely form a cyst with a mural nodule lesion. Read More

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http://Insights.ovid.com/crossref?an=00005792-201901110-0007
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http://dx.doi.org/10.1097/MD.0000000000014102DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6336597PMC
January 2019
2 Reads

Tissue-type mapping of gliomas.

Neuroimage Clin 2018 Dec 25:101648. Epub 2018 Dec 25.

Neurosciences Research Centre, Molecular and Clinical Sciences Research Institute, St. George's, University of London, Cranmer Terrace, London SW17 0RE, UK. Electronic address:

Purpose: To develop a statistical method of combining multimodal MRI (mMRI) of adult glial brain tumours to generate tissue heterogeneity maps that indicate tumour grade and infiltration margins.

Materials And Methods: We performed a retrospective analysis of mMRI from patients with histological diagnosis of glioma (n = 25). H Magnetic Resonance Spectroscopic Imaging (MRSI) was used to label regions of "pure" low- or high-grade tumour across image types. Read More

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http://dx.doi.org/10.1016/j.nicl.2018.101648DOI Listing
December 2018
1 Read

The role of diffusion and perfusion magnetic resonance imaging in differentiation of haemangioblastomas and pilocytic astrocytomas.

Pol J Radiol 2018 10;83:e197-e203. Epub 2018 May 10.

Department of General and Interventional Radiology and Neuroradiology, Wroclaw Medical University, Poland.

Purpose: Haemangioblastomas (HABLs) and pilocytic astrocytomas (PAs) are brain tumours presenting similar appearance and location in conventional magnetic resonance (MR) imaging. The purpose of our study was to determine whether a detailed analysis of diffusion (DWI) and perfusion (PWI) characteristics can be useful in preoperative differentiation of these tumours.

Material And Methods: The study group consisted of biopsy proven six HABLs and six PAs, which underwent preoperative standard MR examinations including PWI and DWI. Read More

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https://www.termedia.pl/doi/10.5114/pjr.2018.75870
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http://dx.doi.org/10.5114/pjr.2018.75870DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6323599PMC
May 2018
4 Reads

Ganglioglioma Arising from the Septum Pellucidum: Case Report and Review of the Literature.

Pediatr Neurosurg 2019 Jan 8:1-10. Epub 2019 Jan 8.

Department of Neurological Surgery, University of Virginia Health Science Center, University of Virginia, Charlottesville, Virginia,

Background: Gangliogliomas are low-grade neoplasms that typically affect patients under the age of 30 and present with epilepsy and symptoms of mass effect. Here, we report a case of an intraventricular ganglioglioma involving the septum pellucidum in a pediatric patient with history of optic glioma. Only one other pediatric intraventricular ganglioglioma arising from the septum pellucidum has been reported previously. Read More

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https://www.karger.com/Article/FullText/495043
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http://dx.doi.org/10.1159/000495043DOI Listing
January 2019
11 Reads
0.497 Impact Factor

Texture analysis on conventional MRI images accurately predicts early malignant transformation of low-grade gliomas.

Eur Radiol 2019 Jan 7. Epub 2019 Jan 7.

Department of Radiology, Weill Cornell Medicine, 407 E 61st Street Suite 107, New York, NY, 10065, USA.

Objectives: Texture analysis performed on MRI images can provide additional quantitative information that is invisible to human assessment. This study aimed to evaluate the feasibility of texture analysis on preoperative conventional MRI images in predicting early malignant transformation from low- to high-grade glioma and compare its utility to histogram analysis alone.

Methods: A total of 68 patients with low-grade glioma (LGG) were included in this study, 15 of which showed malignant transformation. Read More

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http://dx.doi.org/10.1007/s00330-018-5921-1DOI Listing
January 2019
2 Reads

Conventionally fractionated stereotactic radiotherapy (CFRT) in combination with dose-dense temozolomide (TMZ) in relapsed malignant glioma: A case report.

Medicine (Baltimore) 2019 Jan;98(1):e13869

Department of Radiation Oncology, Affiliated Hospital of Hebei University, Baoding, Hebei, P.R. China.

Rationale: At present, there is no uniform consensus on the treatment of recurrent glioblastoma, especially the re-irradiation dose and temozolomide (TMZ) dose. The literature on the treatment of recurrent glioblastoma (GBM) by conventionally fractionated stereotactic radiotherapy (CFRT) is even rarer.

Patient Concerns: A 44-year-old woman was admitted to our hospital for residual tumor after reoperation. Read More

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http://dx.doi.org/10.1097/MD.0000000000013869DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6344191PMC
January 2019
1 Read

Manifestation of a solitary retinal astrocytic hamartoma in a patient with Best macular dystrophy.

Am J Ophthalmol Case Rep 2019 Mar 11;13:80-82. Epub 2018 Dec 11.

Casey Eye Institute at Oregon Health & Science University, United States.

Purpose: To report the case of an adolescent male with a history of Best macular dystrophy and retinal astrocytic hamartoma.

Observations: A 15 year old male with a history of Best macular dystrophy who had been followed by ophthalmology for 9 years was noted to have progressive enlargement of a superonasal peripapillary retinal lesion. Imaging and exam are consistent with a diagnosis of retinal astrocytic hamartoma. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S24519936183033
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http://dx.doi.org/10.1016/j.ajoc.2018.12.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6299127PMC
March 2019
6 Reads

Successful treatment with temozolomide in an elderly woman with advanced pulmonary large-cell neuroendocrine carcinoma: A case report.

Medicine (Baltimore) 2018 Dec;97(51):e13318

Department of Medical Oncology.

Rationale: Pulmonary large-cell neuroendocrine carcinoma (LCNEC) is a rare type of lung cancer, and 40% of patients are in stage IV at initial diagnosis. It has an extremely poor prognosis with a 1-year survival rate of 27%. Patients with LCNEC are predominantly male, older, and heavy smokers. Read More

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http://Insights.ovid.com/crossref?an=00005792-201812210-0001
Publisher Site
http://dx.doi.org/10.1097/MD.0000000000013318DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6320007PMC
December 2018
2 Reads

[Diffuse Astrocytoma with Pilomyxoid Features Presenting as Intratumoral Hemorrhage:A Case Report].

No Shinkei Geka 2018 Dec;46(12):1073-1079

Department of Neurosurgery(Omori), School of Medicine, Faculty of Medicine, Toho University.

Hemorrhagic low-grade glioma(LGG)without malignant transformation is rare, accounting for less than 1% of cases. To the best of our knowledge, hemorrhagic LGG with an arteriovenous(AV)shunt has not been reported. We report the case of 17-year-old man with LGG with an AV shunt. Read More

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http://dx.doi.org/10.11477/mf.1436203870DOI Listing
December 2018
9 Reads

Intraventricular Pilocytic Astrocytoma With KIAA1549/BRAF Fusion Arising in a 44-Year Old.

J Neuropathol Exp Neurol 2019 Feb;78(2):187-190

Department of Pathology, Duke University, Durham, North Carolina.

Rare pilocytic astrocytomas (PA) have been described to arise in the ventricles of children. They are even less common in this location for the adult population. We present the case of a 44-year old man presenting with vision and mental status changes. Read More

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http://dx.doi.org/10.1093/jnen/nly116DOI Listing
February 2019
1 Read

Tanycytic ependymoma of filum terminale: Clinical characteristics and surgical outcomes.

Oncol Lett 2018 Dec 1;16(6):6910-6917. Epub 2018 Oct 1.

Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing 100050, P.R. China.

Tanycytic ependymoma (TE), a rare subtype of ependymoma, was classified as grade II ependymoma by the World Health Organization in 2000 and 2007. Preoperative diagnosis of TE is challenging due to its similarities to schwannoma and astrocytoma; therefore, differentiation is required. The present study investigated the clinical, imaging and pathological characteristics of TE in the filum terminale. Read More

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http://www.spandidos-publications.com/10.3892/ol.2018.9531
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http://dx.doi.org/10.3892/ol.2018.9531DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6256739PMC
December 2018
7 Reads

Grading and proliferation assessment of diffuse astrocytic tumors with monoexponential, biexponential, and stretched-exponential diffusion-weighted imaging and diffusion kurtosis imaging.

Eur J Radiol 2018 Dec 5;109:188-195. Epub 2018 Nov 5.

Department of Radiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China. Electronic address:

Purpose: To compare the main parameters derived from monoexponential, biexponential and stretched-exponential diffusion-weighted imaging (DWI) and diffusion kurtosis imaging (DKI) with respect to diagnostic performance for tumor grading and proliferation assessment in diffuse astrocytic tumors (DATs).

Materials And Methods: Fifty-eight pathologically confirmed DAT patients who underwent DWI and DKI on a 3-T scanner were prospectively collected and retrospectively reviewed. Measurements including the apparent diffusion coefficient (ADC), true diffusion coefficient (D), pseudodiffusion coefficient (D), perfusion fraction (f), distributed diffusion coefficient (DDC), heterogeneity index (α), mean diffusivity (MD), fractional anisotropy (FA), and mean kurtosis (MK) were compared between tumor grades (Ⅱ, Ⅲ, and Ⅳ) by using a Jonckheere-Terpstra test. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0720048X183039
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http://dx.doi.org/10.1016/j.ejrad.2018.11.003DOI Listing
December 2018
8 Reads

Diffusion Kurtosis Imaging Reflects Glial Fibrillary Acidic Protein (GFAP), Topo IIα, and O⁶-Methylguanine-DNA Methyltransferase (MGMT) Expression in Astrocytomas.

Med Sci Monit 2018 Dec 6;24:8822-8830. Epub 2018 Dec 6.

Department of Radiology, First Clinical Medical College, Shanxi Medical University, Taiyuan, Shanxi, China (mainland).

BACKGROUND Astrocytomas are the most common primary brain neoplasms. Biological indicators of astrocytomas can reflect its biological characteristics. The aim of this study was to assess the expression of the pathological glial fibrillary acidic protein (GFAP) Topo IIα and O⁶-methylguanine-DNA methyltransferase (MGMT) in astrocytomas using magnetic resonance (MR) diffusion kurtosis imaging (DKI) to evaluate the biological characteristics of astrocytomas. Read More

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https://www.medscimonit.com/abstract/index/idArt/911631
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http://dx.doi.org/10.12659/MSM.911631DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6292149PMC
December 2018
9 Reads

Awake Transcortical Approach Resection of Dominant Posterior Cingulate Gyrus Glioma: 2-Dimensional Operative Video.

Oper Neurosurg (Hagerstown) 2018 Nov 28. Epub 2018 Nov 28.

Department of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, China.

Two techniques, the translongitudinal cerebral fissure and transfrontal cortical approach, can be employed to resect posterior cingulate gyrus tumors. We demonstrate the transcortical technique comprising of multimodal imaging guidance and awake brain mapping which enabled maximum safe resection of dominant cingulate gyrus glioma. The patient, a 49-yr-old female, came to clinic after experiencing headache for a month. Read More

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https://academic.oup.com/ons/advance-article/doi/10.1093/ons
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http://dx.doi.org/10.1093/ons/opy347DOI Listing
November 2018
13 Reads

Intramedullary spinal cord ependymoma and astrocytoma: intraoperative frozen-section diagnosis, extent of resection, and outcomes.

Authors:

J Neurosurg Spine 2018 Oct 1:1-7. Epub 2018 Oct 1.

OBJECTIVEThe intraoperative differentiation of ependymomas from astrocytomas is important because neurosurgical strategies differ between these two tumor groups. Previous studies have reported that the diagnostic accuracy of intraoperative frozen sections of intracranial central nervous system (CNS) tumors is higher than 83%-97%, whereas that for spinal intramedullary tumors remains unknown. Herein, authors tested the hypothesis that intraoperative frozen-section diagnosis is the gold standard for a differential diagnosis of intramedullary spinal cord tumors. Read More

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http://dx.doi.org/10.3171/2018.7.SPINE18230DOI Listing
October 2018
2 Reads

COMBImage: a modular parallel processing framework for pairwise drug combination analysis that quantifies temporal changes in label-free video microscopy movies.

BMC Bioinformatics 2018 Nov 26;19(1):453. Epub 2018 Nov 26.

Department of Medical Sciences, Cancer Pharmacology and Computational Medicine, Uppsala University, Uppsala, Sweden.

Background: Large-scale pairwise drug combination analysis has lately gained momentum in drug discovery and development projects, mainly due to the employment of advanced experimental-computational pipelines. This is fortunate as drug combinations are often required for successful treatment of complex diseases. Furthermore, most new drugs cannot totally replace the current standard-of-care medication, but rather have to enter clinical use as add-on treatment. Read More

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https://bmcbioinformatics.biomedcentral.com/articles/10.1186
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http://dx.doi.org/10.1186/s12859-018-2458-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6257977PMC
November 2018
12 Reads

Periostin concentrations in childhood-onset craniopharyngioma patients.

J Endocrinol Invest 2018 Nov 24. Epub 2018 Nov 24.

Department of Pediatrics and Pediatric Hematology/Oncology, University Children's Hospital, Klinikum Oldenburg AöR, 26133, Oldenburg, Germany.

Purpose: Periostin is highly expressed in craniopharyngioma (CP)-associated fibroblasts and has been identified as a marker for non-alcoholic fatty liver disease (NAFLD). Half of CP patients with hypothalamic syndrome develop NAFLD. We hypothesized that periostin concentration is elevated in biological fluids of CP and associated with pathological hepatic parameters, indicating increased risk for NAFLD. Read More

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http://link.springer.com/10.1007/s40618-018-0987-9
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http://dx.doi.org/10.1007/s40618-018-0987-9DOI Listing
November 2018
8 Reads

MRI based texture analysis to classify low grade gliomas into astrocytoma and 1p/19q codeleted oligodendroglioma.

Magn Reson Imaging 2019 Apr 19;57:254-258. Epub 2018 Nov 19.

Department of Radiology, Weill Cornell Medicine, New York, NY, USA. Electronic address:

Purpose: Texture analysis performed on MR images can detect quantitative features that are imperceptible to human visual assessment. The purpose of this study was to evaluate the feasibility of texture analysis on preoperative conventional MRI to discriminate between histological subtypes in low-grade gliomas (LGGs), and to determine the utility of texture analysis compared to histogram analysis alone.

Methods: A total of 41 patients with LGG, 21 astrocytoma and 20 1p/19q codeleted oligodendroglioma were included in this study. Read More

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http://dx.doi.org/10.1016/j.mri.2018.11.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6347382PMC
April 2019
7 Reads

Integrated mapping of pharmacokinetics and pharmacodynamics in a patient-derived xenograft model of glioblastoma.

Nat Commun 2018 11 21;9(1):4904. Epub 2018 Nov 21.

Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02115, USA.

Therapeutic options for the treatment of glioblastoma remain inadequate despite concerted research efforts in drug development. Therapeutic failure can result from poor permeability of the blood-brain barrier, heterogeneous drug distribution, and development of resistance. Elucidation of relationships among such parameters could enable the development of predictive models of drug response in patients and inform drug development. Read More

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http://dx.doi.org/10.1038/s41467-018-07334-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6249307PMC
November 2018
8 Reads

Pilocytic Astrocytoma with Gangliocytic Differentiation to Pilomyxoid Astrocytoma-expanding the Morphological Spectrum: Case Report and Literature Review.

Asian J Neurosurg 2018 Oct-Dec;13(4):1193-1196

Department of Neurosurgery, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

We present a rare case of pilocytic astrocytoma (PA) with gangliocytic differentiation arising in the suprasellar/chiasmatic region in a young boy that showed a rapid regrowth after the 1 subtotal resection and "differentiated" into pilomyxoid astrocytoma (PMA) in subsequent recurrences. The clinical course, imaging, and histological features have been described with a review of the literature. While PA is well-circumscribed, biphasic tumors with bipolar piloid cells, those arising in the diencephalic region often contain myxoid stroma, angiocentric pattern, and "intermediate" features between PA and PMA. Read More

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http://dx.doi.org/10.4103/ajns.AJNS_247_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6208220PMC
November 2018
10 Reads

A malignant astrocytoma with uncommon angiocentric features and dot-like EMA expression.

Contemp Oncol (Pozn) 2018 30;22(3):205-208. Epub 2018 Sep 30.

Department of Pathology, Chair of Oncology, Medical University of Lodz, Poland.

Angiocentric features are uncommon in high-grade World Health Organisation (WHO) brain tumours, whilst they are typical for WHO grade I tumours, e.g. angiocentric gliomas. Read More

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https://www.termedia.pl/doi/10.5114/wo.2018.78944
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http://dx.doi.org/10.5114/wo.2018.78944DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6238096PMC
September 2018
9 Reads

Overall survival prediction in glioblastoma multiforme patients from volumetric, shape and texture features using machine learning.

Surg Oncol 2018 Dec 10;27(4):709-714. Epub 2018 Sep 10.

National University of Singapore, Singapore. Electronic address:

Glioblastoma multiforme (GBM) are aggressive brain tumors, which lead to poor overall survival (OS) of patients. OS prediction of GBM patients provides useful information for surgical and treatment planning. Radiomics research attempts at predicting disease prognosis, thus providing beneficial information for personalized treatment from a variety of imaging features extracted from multiple MR images. Read More

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http://dx.doi.org/10.1016/j.suronc.2018.09.002DOI Listing
December 2018

Tumour volume reduction following PET guided intensity modulated radiation therapy and temozolomide in IDH mutated anaplastic glioma.

J Clin Neurosci 2019 Jan 14;59:68-74. Epub 2018 Nov 14.

Northern Sydney Cancer Centre, Royal North Shore Hospital, Sydney, Australia; Sydney Medical School, University of Sydney, Sydney, Australia; Sydney NeuroOncology Group, Sydney, Australia.

The role of maximal surgical debulking in isocitrate dehydrogenase (IDH) mutated anaplastic glioma prior to adjuvant radiation therapy remains uncertain. This study assessed the reduction in tumour volume following intensity modulated radiation therapy (IMRT) and temozolomide in this favourable and more responsive tumour pathology. 56 patients were managed from 2011 to 2014 and 53 had residual disease. Read More

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http://dx.doi.org/10.1016/j.jocn.2018.11.005DOI Listing
January 2019
3 Reads

Long-term Seizure Disorder Caused by a Dermoid Cyst with Catastrophic Developments.

Cureus 2018 Sep 10;10(9):e3272. Epub 2018 Sep 10.

Surgery/Neurosurgery, University of Toledo Medical Center, Toledo, USA.

Glioblastoma multiforme (GBM) is a World Health Organization (WHO) grade IV primary malignant astrocytoma. Aneurysms are devastating intracranial neurovascular pathologies. Intracranial dermoid cysts are common, benign lesions which can be clinically silent or associated with seizure disorder. Read More

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https://www.cureus.com/articles/12761-long-term-seizure-diso
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http://dx.doi.org/10.7759/cureus.3272DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6235633PMC
September 2018
10 Reads

Proliferative Index in Pediatric Pilocytic Astrocytoma by Region of Origin and Prediction of Clinical Behavior.

Pediatr Neurosurg 2018 14;53(6):395-400. Epub 2018 Nov 14.

Children's Hospital LA, Los Angeles, California, USA.

Background/aims: Pilocytic astrocytomas are common pediatric tumors. Molecular profiles vary with location of origin. Comparisons of proliferation have not been reported. Read More

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http://dx.doi.org/10.1159/000490466DOI Listing
January 2019
10 Reads

Nanotechnology for Treatment of Glioblastoma Multiforme.

J Transl Int Med 2018 Sep 9;6(3):128-133. Epub 2018 Oct 9.

Department of Neurosurgery, Cedars-Sinai Medical Center, Los Angeles, California, USA.

Glioblastoma multiforme (GBM), a grade IV astrocytoma as defined by the World Health Organization (WHO) criteria, is the most common primary central nervous system tumor in adults. After treatment with the current standard of care consisting of surgical resection, concurrent temozolomide (TMZ), and radiation, the median survival is only 15 months. The limited and less-effective treatment options for these highly aggressive GBMs call for the development of new techniques and the improvement of existing technologies. Read More

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https://content.sciendo.com/view/journals/jtim/6/3/article-p
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http://dx.doi.org/10.2478/jtim-2018-0025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6231306PMC
September 2018
7 Reads

Longitudinal Effects of Everolimus on White Matter Diffusion in Tuberous Sclerosis Complex.

Pediatr Neurol 2019 Jan 18;90:24-30. Epub 2018 Oct 18.

Department of Neurology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.

Objective: We studied the longitudinal effects of everolimus, an inhibitor of the mammalian target of rapamycin (mTOR), on callosal white matter diffusion tensor imaging (DTI) in patients with tuberous sclerosis complex (TSC).

Methods: Serial imaging data spanning nine years were used from the open label, Phase I/II trial (NCT00411619) and open-ended extension phase of everolimus for the treatment of subependymal giant cell astrocytoma associated with TSC. From 28 patients treated with everolimus and 25 untreated control patients, 481 MRI scans were available. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S08878994183092
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http://dx.doi.org/10.1016/j.pediatrneurol.2018.10.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6314307PMC
January 2019
9 Reads

Differentiation between pilocytic astrocytoma and glioblastoma: a decision tree model using contrast-enhanced magnetic resonance imaging-derived quantitative radiomic features.

Eur Radiol 2018 Nov 12. Epub 2018 Nov 12.

Department of Radiology, the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310009, China.

Objective: To differentiate brain pilocytic astrocytoma (PA) from glioblastoma (GBM) using contrast-enhanced magnetic resonance imaging (MRI) quantitative radiomic features by a decision tree model.

Methods: Sixty-six patients from two centres (PA, n = 31; GBM, n = 35) were randomly divided into training and validation data sets (about 2:1). Quantitative radiomic features of the tumours were extracted from contrast-enhanced MR images. Read More

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http://link.springer.com/10.1007/s00330-018-5706-6
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http://dx.doi.org/10.1007/s00330-018-5706-6DOI Listing
November 2018
10 Reads
4.014 Impact Factor

Conformal Radiation Therapy for Pediatric Patients with Low-Grade Glioma: Results from the Children's Oncology Group Phase 2 Study ACNS0221.

Int J Radiat Oncol Biol Phys 2018 Nov 10. Epub 2018 Nov 10.

Department of Radiation Oncology, St. Jude Children's Research Hospital, Memphis, Tennessee. Electronic address:

Purpose: To determine the rate of marginal relapse, progression-free survival (PFS), and overall survival (OS) in patients with pediatric low-grade glioma (PLGG) treated with conformal radiation therapy (CRT) with a clinical target volume (CTV) margin of 5 mm in the Children's Oncology Group trial ACNS0221.

Methods And Materials: Patients aged 3 to 21 years with unresectable progressive, recurrent, or residual PLGG were eligible for this study. Patients younger than 10 years were required to have received at least 1 chemotherapy course. Read More

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http://dx.doi.org/10.1016/j.ijrobp.2018.11.004DOI Listing
November 2018
11 Reads

Unusual Clinical Presentation and Association of Cranial Dermoid Tumor and Tethered Cord Syndrome.

Pediatr Neurosurg 2018 8;53(6):427-431. Epub 2018 Nov 8.

Bahcesehir University, Faculty of Medicine, Department of Neurosurgery, Gaziantep Medical Park Hospital, Gaziantep, Turkey.

Tethered cord syndrome (TCS), a neurological disorder characterized by the lower settlement of the conus medullaris, is a congenital spinal disease which is caused by split cord syndrome, meningomyelocele, and spinal tumors. Cranial dermoid tumor (CDT) is a congenital benign tumor which is generally located on the midline of the cranium. Even though TCS is highly associated with spinal dermoid tumor, the relationship of CDT and TCS is unusual. Read More

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http://dx.doi.org/10.1159/000494087DOI Listing
January 2019
34 Reads
0.500 Impact Factor

Mathematically universal and biologically consistent astrocytoma genotype encodes for transformation and predicts survival phenotype.

APL Bioeng 2018 Sep 19;2(3). Epub 2018 Sep 19.

Scientific Computing and Imaging Institute, University of Utah, Salt Lake City, Utah 84112, USA.

DNA alterations have been observed in astrocytoma for decades. A copy-number genotype predictive of a survival phenotype was only discovered by using the generalized singular value decomposition (GSVD) formulated as a comparative spectral decomposition. Here, we use the GSVD to compare whole-genome sequencing (WGS) profiles of patient-matched astrocytoma and normal DNA. Read More

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http://aip.scitation.org/doi/10.1063/1.5037882
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http://dx.doi.org/10.1063/1.5037882DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6215493PMC
September 2018
7 Reads

Machine learning based on multi-parametric magnetic resonance imaging to differentiate glioblastoma multiforme from primary cerebral nervous system lymphoma.

Eur J Radiol 2018 Nov 14;108:147-154. Epub 2018 Sep 14.

Department of Diagnostic Radiology, Graduate School of Life Sciences, Kumamoto University, 1-1-1 Honjo, Chuoku, Kumamoto, 860-8556, Japan. Electronic address:

Purpose: To evaluate the performance of a machine learning method based on texture features in multi-parametric magnetic resonance imaging (MRI) to differentiate a glioblastoma multiforme (GBM) from a primary cerebral nervous system lymphoma (PCNSL).

Materials And Methods: We included 70 patients who underwent contrast enhanced brain MRI at 3 T with brain tumors diagnosed as GBM (n = 45) and PCNSL (n = 25) in this retrospective study. Twelve histograms and texture parameters were assessed on T2-weighted images (T2WIs), apparent diffusion coefficient maps, relative cerebral blood volume (rCBV) map, and contrast-enhanced T1-weighted images (CE-T1WIs). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0720048X183032
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http://dx.doi.org/10.1016/j.ejrad.2018.09.017DOI Listing
November 2018
12 Reads

Ictal SPECT reveals different epileptogenic zones in frontal lobe epilepsy.

Epileptic Disord 2018 Oct;20(5):447-450

Epilepsy Center, Department of Neurology, University of Munich, Munich, Germany.

We report a patient with frontal lobe epilepsy due to a right frontal astrocytoma (WHO Grade III) in whom two ictal SPECTs (single photon emission tomography) were performed during two seizures with different semiology and different EEG seizure patterns. Subtraction of ictal and interictal SPECT showed right lateral frontal hyperperfusion during a left face clonic seizure, and right mesial fronto-polar hyperperfusion during a subclinical seizure. This report demonstrates that ictal SPECT may reflect different seizure semiology from the frontal lobe of the same individual and that simultaneous EEG is indispensable for the correct interpretation of SPECT in epilepsy. Read More

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http://dx.doi.org/10.1684/epd.2018.0991DOI Listing
October 2018
9 Reads

A comparison of pseudo-continuous arterial spin labelling and dynamic susceptibility contrast MRI with and without contrast agent leakage correction in paediatric brain tumours.

Br J Radiol 2019 Feb 3;92(1094):20170872. Epub 2019 Jan 3.

1 Birmingham Children's Hospital , Birmingham , UK.

Objective:: To investigate correlations between MRI perfusion metrics measured by dynamic susceptibility contrast and arterial spin labelling in paediatric brain tumours.

Methods:: 15 paediatric patients with brain tumours were scanned prospectively using pseudo-continuous arterial spin labelling (ASL) and dynamic susceptibility contrast (DSC-) MRI with a pre-bolus to minimise contrast agent leakage. Cerebral blood flow (CBF) maps were produced using ASL. Read More

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http://dx.doi.org/10.1259/bjr.20170872DOI Listing
February 2019
5 Reads

Endoscopic transnasal resection of optic pathway pilocytic astrocytoma.

Childs Nerv Syst 2019 Jan 18;35(1):73-81. Epub 2018 Oct 18.

Department of Neurosurgery, King Saud University, Riyadh, Saudi Arabia.

Purpose: Optic pathway gliomas (OPGs) are low-grade neoplasms that primarily affect children. The management of OPGs remains controversial. Reports on the use of the endoscopic endonasal approach (EEA) in OPGs are extremely limited, and no such reports exist on its utility for pediatric OPGs. Read More

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http://link.springer.com/10.1007/s00381-018-3994-4
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http://dx.doi.org/10.1007/s00381-018-3994-4DOI Listing
January 2019
17 Reads
1.163 Impact Factor

Subcortical Calculation Mapping During Parietal Glioma Surgery in the Dominant Hemisphere: A Case Report.

World Neurosurg 2019 Jan 13;121:205-210. Epub 2018 Oct 13.

Department of Neurosurgery, Nara Medical University, Kashihara, Japan.

Background: To avoid permanent neurologic deficits and preserve brain function in and near the eloquent area, intraoperative electrical stimulation mapping (IESM) is necessary. However, little is known about how these subcortical regions are involved in calculation processing function in patients with glioma.

Case Description: We report the case of a 56-year-old, right-handed woman working at a primary school as a teacher who had recurrent left parietal glioma. Read More

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http://dx.doi.org/10.1016/j.wneu.2018.10.046DOI Listing
January 2019
5 Reads

Rare and rarer: co-occurrence of stroke-like migraine attacks after radiation therapy and Charles Bonnet syndromes.

Oxf Med Case Reports 2018 Oct 5;2018(10):omy077. Epub 2018 Oct 5.

Neurology Department, Townsville Hospital and Health Service, Douglas, Queensland, Australia.

A 30-year-old man presented with new onset severe headache and homonymous hemianopia, with a subsequent seizure, on a background of a right parietal astrocytoma resected at age 5 with adjuvant chemotherapy and radiotherapy. Magnetic resonance imaging of the brain revealed post-surgical and radiotherapy changes only and a clinical diagnosis of Stroke-like Migraine Attacks after Radiation Therapy (SMART) syndrome was made. Vision subsequently recovered gradually over a 6-week period, however, during the recovery phase he reported well formed hallucinations in the affected hemi-field consisting of small mammals, particularly possums, which gradually became less distinct as vision recovered; a phenomenon which was felt likely to represent the Charles Bonnet syndrome. Read More

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http://dx.doi.org/10.1093/omcr/omy077DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6172599PMC
October 2018
3 Reads

Comparison of Survival Outcomes Between Partial Resection and Biopsy for Primary Glioblastoma: A Propensity Score-Matched Study.

World Neurosurg 2019 Jan 11;121:e858-e866. Epub 2018 Oct 11.

Department of Neurological Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.

Objectives: Gross total resection for glioblastoma (GBM) has been associated with better prognosis. However, it is not always feasible, and the threshold for the extent of resection required for better prognosis has been controversial. Therefore, we compared the survival and clinical outcomes of patients with GBM who had undergone partial resection (PR) or biopsy. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S18788750183229
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http://dx.doi.org/10.1016/j.wneu.2018.09.237DOI Listing
January 2019
8 Reads
2.420 Impact Factor

Utility of Magnetic Resonance Perfusion Imaging in Quantifying Active Tumor Fraction and Radiation Necrosis in Recurrent Intracranial Tumors.

World Neurosurg 2019 Jan 9;121:e836-e842. Epub 2018 Oct 9.

Department of Neurosurgery, University of Miami, Miami, Florida, USA.

Background: Ancillary criteria to identify tumor recurrence such as the McDonald criteria or Response Assessment in Neuro-Oncology criteria can provide false diagnoses. Magnetic resonance perfusion (MRP) imaging has been proposed to differentiate post-treatment changes from recurrence. We investigated the utility of MRP to quantify the histological fraction of active tumor (AT), treatment-related changes, and radiation necrosis in recurrent post-treatment intracranial tumors. Read More

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http://dx.doi.org/10.1016/j.wneu.2018.09.233DOI Listing
January 2019
1 Read

Differentiation of Brain Metastases and Gliomas Based on Color Map of Phase Difference Enhanced Imaging.

Front Neurol 2018 21;9:788. Epub 2018 Sep 21.

Department of Diagnostic and Interventional Radiology, Osaka City University Graduate School of Medicine, Osaka, Japan.

Phase difference enhanced imaging (PADRE), a new phase-related MRI technique, can enhance both paramagnetic and diamagnetic substances, and select which phases to be enhanced. Utilizing these characteristics, we developed color map of PADRE (Color PADRE), which enables simultaneous visualization of myelin-rich structures and veins. Our aim was to determine whether Color PADRE is sufficient to delineate the characteristics of non-gadolinium-enhancing T2-hyperintense regions related with metastatic tumors (MTs), diffuse astrocytomas (DAs) and glioblastomas (GBs), and whether it can contribute to the differentiation of MTs from GBs. Read More

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https://www.frontiersin.org/article/10.3389/fneur.2018.00788
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http://dx.doi.org/10.3389/fneur.2018.00788DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6160550PMC
September 2018
14 Reads

Basal fatty acid oxidation increases after recurrent low glucose in human primary astrocytes.

Diabetologia 2019 01 6;62(1):187-198. Epub 2018 Oct 6.

Institute of Biomedical and Clinical Sciences, University of Exeter Medical School, RILD Building, Barrack Road, Exeter, EX2 5DW, UK.

Aims/hypothesis: Hypoglycaemia is a major barrier to good glucose control in type 1 diabetes. Frequent hypoglycaemic episodes impair awareness of subsequent hypoglycaemic bouts. Neural changes underpinning awareness of hypoglycaemia are poorly defined and molecular mechanisms by which glial cells contribute to hypoglycaemia sensing and glucose counterregulation require further investigation. Read More

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http://link.springer.com/10.1007/s00125-018-4744-6
Publisher Site
http://dx.doi.org/10.1007/s00125-018-4744-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6290858PMC
January 2019
4 Reads

Diffuse low grade glioma after the 2016 WHO update, seizure characteristics, imaging correlates and outcomes.

Clin Neurol Neurosurg 2018 Dec 2;175:9-15. Epub 2018 Oct 2.

Department of Neurosurgery, University Hospital of Wales, Heath Park, Cardiff, CF14 4XW, UK.

Objectives: The majority of patients with supratentorial diffuse grade II glioma present with seizures, which adversely affect quality of life. The exact mechanism of epileptogenesis is unknown and the influence of tumour characteristics, radiological and histological, are not well studied, particularly following the introduction of molecular genetics in the 2016 WHO reclassification of gliomas. We sought to define predictors of seizure development and outcome in low grade glioma. Read More

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http://dx.doi.org/10.1016/j.clineuro.2018.10.001DOI Listing
December 2018
9 Reads