9,665 results match your criteria Imaging in Juvenile Pilocytic Astrocytoma


Abnormal spindle-like microcephaly-associated (ASPM) gene expression in posterior fossa brain tumors of childhood and adolescence.

Childs Nerv Syst 2020 Jun 26. Epub 2020 Jun 26.

Department of Pediatrics, Pediatric Oncology Institute-GRAACC, Federal University of São Paulo, São Paulo, SP, Brazil.

Purpose: In neurogenesis, ASPM (abnormal spindle-like microcephaly-associated) gene is expressed mainly in the ventricular zone of posterior fossa and is the major determinant in the cerebral cortex. Besides its role in embryonic development, ASPM overexpression promotes tumor growth, including central nervous system (CNS) tumors. This study aims to investigate ASPM expression levels in most frequent posterior fossa brain tumors of childhood and adolescence: medulloblastoma (MB), ependymoma (EPN), and astrocytoma (AS), correlating them with clinicopathological characteristics and tumor solid portion size. Read More

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http://dx.doi.org/10.1007/s00381-020-04740-1DOI Listing

INCIDENTAL FINDINGS ON BRAIN MAGNETIC RESONANCE IMAGING (MRI) IN PEDIATRIC ENDOCRINE PATIENTS.

Endocr Pract 2020 Jun 23. Epub 2020 Jun 23.

From: Pediatric Endocrinology and Diabetes Unit.

To explore incidental findings on brain magnetic resonance imaging (MRI) studies of pediatric patients referred due to endocrine disorders. A retrospective, observational study conducted in a tertiary referral center. The neuroimaging database of 17,445 brain MRI studies of 11,011 pediatric patients were searched for cases with endocrine referrals and without medical history of malignancy, genetic syndromes and/or neurological comorbidities. Read More

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http://dx.doi.org/10.4158/EP-2020-0208DOI Listing

Clinicopathological analysis of T2-FLAIR mismatch sign in lower-grade gliomas.

Sci Rep 2020 Jun 22;10(1):10113. Epub 2020 Jun 22.

Division of Neurosurgery, Shizuoka Cancer Center, Shizuoka, Japan.

T2-FLAIR mismatch sign is known as a highly specific imaging marker of IDH-mutant astrocytomas. This study was intended to clarify what the T2-FLAIR mismatch sign represents by pathological analysis of lower-grade gliomas rediagnosed in accordance with the WHO 2016 classification. We retrospectively analyzed the records of 64 patients diagnosed with WHO grade II and III diffuse gliomas between June 2009 and November 2018. Read More

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http://dx.doi.org/10.1038/s41598-020-67244-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7308392PMC

The value of intravoxel incoherent motion imaging in predicting the survival of patients with astrocytoma.

Acta Radiol 2020 Jun 17:284185120926907. Epub 2020 Jun 17.

Department of Magnetic Resonance, the First Hospital of Shanxi Medical University, Taiyuan, Shanxi, PR China.

Background: The evaluation of the prognosis of gliomas may have great value in individualized treatment.

Purpose: To evaluate the value of intravoxel incoherent motion (IVIM) in predicting the survival of patients with astrocytoma and comparing it to apparent diffusion coefficients (ADC).

Material And Methods: Sixty patients with pathologically confirmed cerebral astrocytomas underwent IVIM scans before any treatment was performed. Read More

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http://dx.doi.org/10.1177/0284185120926907DOI Listing

Role of the default mode resting-state network for cognitive functioning in malignant glioma patients following multimodal treatment.

Neuroimage Clin 2020 May 26;27:102287. Epub 2020 May 26.

Institute of Neuroscience and Medicine (INM-1, -3, -4), Research Center Juelich, Wilhelm-Johnen-Str., 52428 Juelich, Germany; Department of Nuclear Medicine, University Hospital Aachen, RWTH Aachen University, Pauwelsstr. 30, 52074 Aachen, Germany.

Background: Progressive cognitive decline following multimodal neurooncological treatment is a common observation in patients suffering from malignant glioma. Alterations of the default-mode network (DMN) represent a possible source of impaired neurocognitive functioning and were analyzed in these patients.

Methods: Eighty patients (median age, 51 years) with glioma (WHO grade IV glioblastoma, n = 57; WHO grade III anaplastic astrocytoma, n = 13; WHO grade III anaplastic oligodendroglioma, n = 10) and ECOG performance score 0-1 underwent resting-state functional MRI (rs-fMRI) and neuropsychological testing at a median interval of 13 months (range, 1-114 months) after initiation of therapy. Read More

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http://dx.doi.org/10.1016/j.nicl.2020.102287DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7298724PMC

Neuroimaging of pediatric infratentorial tumors and the value of diffusion-weighted imaging (DWI) in determining tumor grade.

Acta Radiol 2020 Jun 15:284185120933219. Epub 2020 Jun 15.

Department of Pathology, Christian Medical College, Vellore, Tamil Nadu, India.

Background: Diffusion-weighted imaging (DWI) provides information about the cellular density of tumors. This feature is useful in grading and identifying different tumor types.

Purpose: To assess the value of diffusion restriction and apparent diffusion coefficient (ADC) values in differentiating pediatric infratentorial tumors. Read More

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http://dx.doi.org/10.1177/0284185120933219DOI Listing

Intramedullary Masses of the Spinal Cord: Radiologic-Pathologic Correlation.

Radiographics 2020 Jul-Aug;40(4):1125-1145. Epub 2020 Jun 12.

From the Department of Radiology, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Rd, Bethesda, MD 20814 (R.Y.S.); and Department of Radiology, Mayo Clinic, Rochester, Minn (K.K.K.).

Spinal cord tumors are a challenge for patients and neurosurgeons because of the high risk of neurologic deficits from the disease process and surgical interventions. Spinal cord tumors are uncommon, and approximately 2%-3% of primary intra-axial tumors of the central nervous system occur in the spinal cord. Primary intra-axial tumors are usually derived from neuroepithelial tissue, especially glial cells. Read More

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http://dx.doi.org/10.1148/rg.2020190196DOI Listing

Neuroimaging in tuberous sclerosis complex.

Childs Nerv Syst 2020 Jun 9. Epub 2020 Jun 9.

Department of Pediatric Neurosciences, Pediatric Neurosurgery Unit, Santobono-Pausilipon Children's Hospital, Via Mario Fiore n. 6, 80129, Naples, Italy.

Introduction: Tuberous sclerosis complex (TSC) is a rare autosomal dominant disorder affecting multiple systems, due to inactivating mutations of TSC1 or TSC2 mTOR pathway genes. Neurological manifestations are observed in about 95% cases, representing the most frequent cause of morbidity and one of the most common causes of mortality.

Background: Neuroimaging is crucial for early diagnosis, monitoring, and management of these patients. Read More

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http://dx.doi.org/10.1007/s00381-020-04705-4DOI Listing

Exploring the Feasibility and Effects of a Ketogenic Diet in Patients With CNS Malignancies: A Retrospective Case Series.

Front Neurosci 2020 19;14:390. Epub 2020 May 19.

Cedars-Sinai Medical Center, Samuel Oschin Comprehensive Cancer Center, Los Angeles, CA, United States.

Recently, the ketogenic diet has been proposed as an adjunct treatment for a range of medical conditions including weight loss, diabetes, cancer, and neurodegenerative diseases. Because malignant CNS tumors are highly dependent on glucose, the use of a ketogenic diet as an adjunct therapy is currently being explored. This case series summarizes our experience implementing a ketogenic diet for patients with CNS malignancies. Read More

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http://dx.doi.org/10.3389/fnins.2020.00390DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7248360PMC

Safety of immediate use of nonsteroidal antiinflammatory drugs after pediatric craniotomy for tumor.

J Neurosurg Pediatr 2020 Jun 5:1-7. Epub 2020 Jun 5.

Objective: Postoperative pain can limit the recovery of children undergoing craniotomy for tumor resection, and pain management is highly variable between institutions and practitioners. Nonsteroidal antiinflammatory drugs (NSAIDs) are effective in treating postoperative pain following craniotomy, but their use has been limited by concerns about postoperative hemorrhage. The risk of postoperative hemorrhage is not insignificant in patients undergoing craniotomy for tumor resection. Read More

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http://dx.doi.org/10.3171/2020.4.PEDS2055DOI Listing

Glioblastoma multiforme that unusually present with radiographic dural tails: Questioning the diagnostic paradigm with a rare case report.

Radiol Case Rep 2020 Jul 8;15(7):1087-1090. Epub 2020 May 8.

Icahn School of Medicine at Mount Sinai-Elmhurst Hospital, Queens, New York, NY.

Glioblastoma multiforme (GBM) is both the most common as well as one of the most aggressive primary intracerebral tumors. It classically presents on magnetic resonance imaging as a heterogeneous ring-enhancing lesion in the brain parenchyma with central necrosis. This type of neoplasm can also rarely present, however, as a mass with meningeal attachment and radiographic evidence of a dural tail, which was until recently thought to be specific to meningiomas. Read More

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http://dx.doi.org/10.1016/j.radcr.2020.05.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7256235PMC

Occurrence of Glioma in Pregnant Patients: An Institutional Case Series and Review of the Literature.

Anticancer Res 2020 Jun;40(6):3453-3457

Department of Neurology & Neurotherapeutics, UT Southwestern Medical Center, Dallas, TX, U.S.A.

Background/aim: Gliomas present a uniquely challenging clinical situation in the context of pregnancy, with no standard recommendations. This case series aimed to describe the treatment regimen and outcomes of five pregnant patients with gliomas.

Patients And Methods: This is a retrospective study. Read More

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http://dx.doi.org/10.21873/anticanres.14331DOI Listing

Fractionated Stereotactic Sequential Boost in a Selected Cohort of Glioblastoma Patients: A Mono-institutional Analysis.

Anticancer Res 2020 Jun;40(6):3387-3393

Radiation Oncology Division, Perugia General Hospital, Perugia, Italy.

Aim: To retrospectively assess toxicity and survival in 15 selected Glioblastoma patients treated with a sequential fractionated stereotactic radiotherapy (FSRT) boost after chemo-radiotherapy (CHT-RT) and compare their survival outcomes with a control group.

Patients And Methods: Toxicity was assessed with the CTCAE 3.0 scale. Read More

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http://dx.doi.org/10.21873/anticanres.14322DOI Listing

TSC2 pathogenic variants are predictive of severe clinical manifestations in TSC infants: results of the EPISTOP study.

Genet Med 2020 May 28. Epub 2020 May 28.

Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.

Purpose: To perform comprehensive genotyping of TSC1 and TSC2 in a cohort of 94 infants with tuberous sclerosis complex (TSC) and correlate with clinical manifestations.

Methods: Infants were enrolled at age <4 months, and subject to intensive clinical monitoring including electroencephalography (EEG), brain magnetic resonance imaging (MRI), and neuropsychological assessment. Targeted massively parallel sequencing (MPS), genome sequencing, and multiplex ligation-dependent probe amplification (MLPA) were used for variant detection in TSC1/TSC2. Read More

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http://dx.doi.org/10.1038/s41436-020-0823-4DOI Listing

Fluorescein-guided surgery for spinal gliomas: Analysis of 220 consecutive cases.

Int Rev Neurobiol 2020 13;151:139-154. Epub 2020 May 13.

Department of Neurosurgery, Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua University, Beijing, China. Electronic address:

Objective: Sodium fluorescein (FL) is widely used as a fluorescent tracer for brain tumor resection. However, FL-guided resection of spinal gliomas has been reported only occasionally. To evaluate the safety, characteristics, and usefulness of FL-guided surgery in the resection of spinal glioma. Read More

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http://dx.doi.org/10.1016/bs.irn.2020.03.004DOI Listing

Advantage of high b value diffusion-weighted imaging for differentiation of common pediatric brain tumors in posterior fossa.

Eur J Radiol 2020 Jul 5;128:108983. Epub 2020 May 5.

Department of Neurosurgery, Graduate School of Biomedical and Health Sciences, Hiroshima University, 1-2-3, Kasumi, Minami-ku, Hiroshima, Japan. Electronic address:

Purpose: The pediatric posterior fossa (PF) brain tumors with higher frequencies are embryonal tumors (ET), ependymal tumors (EPN) and pilocytic astrocytomas (PA), however, it is often difficult to make a differential diagnosis among them with conventional MRI. The ADC calculated from DWI could be beneficial for diagnostic work up.

Method: We acquired DWI at b = 1000 and 4000(s/mm). Read More

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http://dx.doi.org/10.1016/j.ejrad.2020.108983DOI Listing
July 2020
2.369 Impact Factor

The clinical significance of the T2-FLAIR mismatch sign in grade II and III gliomas: a population-based study.

BMC Cancer 2020 May 20;20(1):450. Epub 2020 May 20.

Department of Neurosurgery, Sahlgrenska University Hospital, Gothenburg, Sweden.

Background: The T2-FLAIR mismatch sign is an imaging finding highly suggestive of isocitrate dehydrogenase mutated (IDH-mut) 1p19q non-codeleted (non-codel) gliomas (astrocytomas). In previous studies, it has shown excellent specificity but limited sensitivity for IDH-mut astrocytomas. Whether the mismatch sign is a marker of a clinically relevant subtype of IDH-mut astrocytomas is unknown. Read More

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http://dx.doi.org/10.1186/s12885-020-06951-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7238512PMC

Tc-CXCR4-L for Imaging of the Chemokine-4 Receptor Associated with Brain Tumor Invasiveness: Biokinetics, Radiation Dosimetry, and Proof of Concept in Humans.

Contrast Media Mol Imaging 2020 27;2020:2525037. Epub 2020 Apr 27.

Departamento de Materiales Radiactivos, Instituto Nacional de Investigaciones Nucleares (ININ), Ocoyoacac 52750, Estado de México, Mexico.

Overexpression of the chemokine-4 receptor (CXCR4) in brain tumors is associated with high cancer cell invasiveness. Recently, we reported the preclinical evaluation of Tc-CXCR4-L (cyclo-D-Tyr-D-[NMe]Orn[EDDA-Tc-6-hydrazinylnicotinyl]-Arg-NaI-Gly) as a SPECT radioligand capable of specifically detecting the CXCR4 protein. This research aimed to estimate the biokinetic behavior and radiation dosimetry of Tc-CXCR4-L in healthy subjects, as well as to correlate the radiotracer uptake by brain tumors in patients, with the histological grade of differentiation and CXCR4 expression evaluated by immunohistochemistry. Read More

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http://dx.doi.org/10.1155/2020/2525037DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7201577PMC

Magnetic Resonance Elastography reveals effects of anti-angiogenic glioblastoma treatment on tumor stiffness and captures progression in an orthotopic mouse model.

Cancer Imaging 2020 May 12;20(1):35. Epub 2020 May 12.

Department of Radiology, Brigham and Women's Hospital, Boston, MA, USA.

Background: Anti-angiogenic treatment of glioblastoma (GBM) complicates radiologic monitoring. We evaluated magnetic resonance elastography (MRE) as an imaging tool for monitoring the efficacy of anti-VEGF treatment of GBM.

Methods: Longitudinal studies were performed in an orthotopic GBM xenograft mouse model. Read More

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http://dx.doi.org/10.1186/s40644-020-00314-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7218549PMC

The biological and clinical basis for early referral of low grade glioma patients to a surgical neuro-oncologist.

J Clin Neurosci 2020 May 4. Epub 2020 May 4.

Department of Neurosurgery, University of Calgary, Alberta, Canada.

The discovery of IDH1/2 (isocitrate dehydrogenase) mutation in large scale, genomewide mutational analyses of gliomas has led to profound developments in understanding tumourigenesis, and restructuring of the classification of both high and low grade gliomas. Owing to this progress made in the recognition of molecular markers which predict tumour behavior and treatment response, the increasing importance of adjuvant treatments such as chemo- and radiotherapy, and the tremendous advances in surgical technique and intraoperative monitoring which have facilitated superior extents of resection whilst preserving neurological functioning and quality of life, contemporary management of low grade glioma (LGG) has switched from a passive, observant approach to a more active, interventional one. Furthermore, this has implications for the manner in which patients with incidentally discovered and/or asymptomatic LGG are managed, and this review of the biological behaviour of LGG, as well as its clinical investigation and management, should act as a timely reminder to all clinicians of the importance of referring LGG patients early to a surgical neuro-oncologist who is not only familiar and acquainted with the vagaries of this disease process, but who, in addition, is devoted to delivering care to these patients with the support of a multi-disciplinary clinical decision-making unit, comprising medical neuro-oncologists, radiation oncologists and allied health professionals. Read More

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http://dx.doi.org/10.1016/j.jocn.2020.04.119DOI Listing

A biphasic tumor in posterior cranial fossa and the pineal region in young adult.

Surg Neurol Int 2020 11;11:64. Epub 2020 Apr 11.

Departments of Neurosurgery, University Hospital Dubrava, Zagreb, Croatia.

Background: Biphasic tumors of the central nervous system are rarely described and mainly consisted out of the glial and mesenchymal component. The tumor originated out of both astrocytes and pinealocytes, best to our knowledge, has not been described. We present a case of a brain tumor consisted out of pilocytic astrocytoma (PA) and pineocytoma as components situated in the pineal region and posterior cranial fossa in young adult. Read More

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http://dx.doi.org/10.25259/SNI_288_2019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7193197PMC

The Diagnostic Value of Conventional MRI and CT Features in the Identification of the IDH1-Mutant and 1p/19q Co-Deletion in WHO Grade II Gliomas.

Acad Radiol 2020 Apr 28. Epub 2020 Apr 28.

Department of Neurosurgery, First Medical Center, Chinese PLA General Hospital, Beijing, China. Electronic address:

Rationale And Objectives: The classification of patients based on pathology and molecular features is important for improving WHO grade II glioma patient prognosis, especially for the initially diagnosed patients. Less invasive and more convenient methods for the prediction of the pathological type and gene status are desired.

Materials And Methods: This study investigates the ability to use conventional magnetic resonance imaging (MRI) and computed tomography (CT) features for determining the Isocitrate Dehydrogenase (IDH)-mutant and 1p/19q-codeletion status, through a retrospective review of information obtained from 189 WHO grade II glioma patients. Read More

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http://dx.doi.org/10.1016/j.acra.2020.03.008DOI Listing

Neuroimaging Findings in Children with Constitutional Mismatch Repair Deficiency Syndrome.

AJNR Am J Neuroradiol 2020 05 30;41(5):904-910. Epub 2020 Apr 30.

From the Department of Radiology (A.K., M.S., S.S., C.H.), Sheba Medical Center, Tel Hashomer, Ramat Gan, Israel.

Background And Purpose: Constitutional mismatch repair deficiency is a hereditary childhood cancer predisposition syndrome characterized by brain tumors and colorectal and hematologic malignancies. Our objective was to describe the neuroimaging findings in patients with constitutional mismatch repair deficiency.

Materials And Methods: This retrospective study included 14 children with genetically confirmed constitutional mismatch repair deficiency who were referred to 2 tertiary pediatric oncology centers. Read More

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http://dx.doi.org/10.3174/ajnr.A6512DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7228156PMC

Recent Advances in Pathology: the 2020 Annual Review Issue of The Journal of Pathology.

J Pathol 2020 Apr;250(5):475-479

RECAMO, Masaryk Memorial Cancer Institute, Brno, Czech Republic.

This year's Annual Review Issue of The Journal of Pathology contains 18 invited reviews on current research areas in pathology. The subject areas reflect the broad range of topics covered by the journal and this year encompass the development and application of software in digital histopathology, implementation of biomarkers in pathology practice; genetics and epigenetics, and stromal influences in disease. The reviews are authored by experts in their field and provide comprehensive updates in the chosen areas, in which there has been considerable recent progress in our understanding of disease. Read More

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http://dx.doi.org/10.1002/path.5425DOI Listing

Clinical characteristics and prognostic factors of adult patients with pilocytic astrocytoma.

J Neurooncol 2020 May 27;148(1):187-198. Epub 2020 Apr 27.

Division of Oncology, Department of Medicine I, Medical University of Vienna, Vienna, Austria.

Introduction: Pilocytic astrocytoma (PA) is the most common primary brain neoplasm in children and treated in curative intent with gross total resection (GTR). However, PA is rare in adults, resulting in limited knowledge on the natural clinical course. This study aimed to describe the clinical course and identify prognostic factors of adult patients with PA. Read More

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http://dx.doi.org/10.1007/s11060-020-03513-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7280326PMC

Magnetic Resonance Imaging Derived Biomarkers of IDH Mutation Status and Overall Survival in Grade III Astrocytomas.

Diagnostics (Basel) 2020 Apr 23;10(4). Epub 2020 Apr 23.

Neuroradiology Unit, S. Chiara Hospital, Trento, Largo Medaglie d'oro 9, 38122 Trento, Italy.

The evaluation of the isocitrate dehydrogenase (IDH) mutation status in the glioma decision-making process has diagnostic, prognostic and therapeutic implications. The aim of this study was to evaluate whether conventional magnetic resonance imaging (MRI) and apparent diffusion coefficient (ADC) can noninvasively predict the most common IDH mutational status (R132H) in GIII-astrocytomas and the overall survival (OS). Hence, twenty-two patients (9-F, 13-M) with a histological diagnosis of GIII-astrocytoma and evaluation of IDH-mutation status (12-wild type, 10-mutant) were retrospectively evaluated. Read More

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http://dx.doi.org/10.3390/diagnostics10040247DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7236014PMC

Ependymoma and pilocytic astrocytoma: Differentiation using radiomics approach based on machine learning.

J Clin Neurosci 2020 Apr 23. Epub 2020 Apr 23.

School of Electrical Engineering, Zhengzhou University, Zhengzhou 450001, China; Industrial Technology Research Institute, Zhengzhou University, Zhengzhou 450001, China; Henan Key Laboratory of Brain Science and Brain-Computer Interface Technology, Zhengzhou University, Zhengzhou 450001, China. Electronic address:

Mandatory accurate and specific diagnosis demands have brought about increased challenges for radiologists in pediatric posterior fossa tumor prediction and prognosis. With the development of high-performance computing and machine learning technologies, radiomics provides increasing opportunities for clinical decision-making. Several studies have applied radiomics as a decision support tool in intracranial tumors differentiation. Read More

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http://dx.doi.org/10.1016/j.jocn.2020.04.080DOI Listing
April 2020
1.318 Impact Factor

Survival, Prognostic Factors, and Volumetric Analysis of Extent of Resection for Anaplastic Gliomas.

Cancer Res Treat 2020 Apr 23. Epub 2020 Apr 23.

Department of Neurosurgery, Yonsei University College of Medicine, Seoul, Korea.

Purpose: The aim of this study is to evaluate the survival rate and prognostic factors of anaplastic gliomas according to the 2016 World Health Organization classification, including extent of resection (EOR) as measured by contrast-enhanced T1-weighted magnetic resonance imaging (MRI) and the T2-weighted MRI.

Materials And Methods: The records of 113 patients with anaplastic glioma who were newly diagnosed at our institute between 2000 and 2013 were retrospectively reviewed. There were 62 cases (54. Read More

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http://dx.doi.org/10.4143/crt.2020.057DOI Listing

Unexpected discovery of a diffuse astrocytoma of the conus medullaris in an elderly NF1 patient.

Radiol Case Rep 2020 Jun 18;15(6):784-788. Epub 2020 Apr 18.

Department of Radiology, Toho University Sakura Medical Center.

Neurofibromatosis type 1 (NF1) is one of the most common genetic neurocutaneous disorders, and it is well known to be associated with peripheral or central nervous system malignancies. The most common malignant tumors are malignant peripheral nerve sheath tumors (MPNSTs); MPNSTs are the most common cause of death in patients with NF1. Central nervous system malignancies rarely occur. Read More

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http://dx.doi.org/10.1016/j.radcr.2020.02.033DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7167499PMC

[The value of analysis of quantitative radiomics based on DTI in predicting astrocytoma IDH1 mutation].

Zhonghua Yi Xue Za Zhi 2020 Apr;100(15):1154-1158

Department of Radiology, the First Affiliated Hospital of Soochow University, Suzhou 215006, China.

Non-invasive prediction of IDH1 mutations by establishing a quantitative radiographic model based on DTI-based whole-tumor texture analysis. Preoperative MRI images of patients with surgically confirmed astrocytoma were collected in the First Affiliated Hospital of Soochow University from February 2016 to June 2019, including T(1)WI, T(2)WI, DTI, and T(1)-contrast enhancement images.A total of 38 patients were included, consisting of 12 mutants and 26 wilds, 20 males and 18 females, the average age was (49±15) years old. Read More

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http://dx.doi.org/10.3760/cma.j.cn112137-20190906-01977DOI Listing

The Use of Rapid Sequence Magnetic Resonance Imaging of the Brain as a Screening Tool for the Detection of Gross Intracranial Pathology in Children Presenting to the Emergency Department With a Chief Complaint of Persistent or Recurrent Headaches.

Pediatr Emerg Care 2020 Apr 16. Epub 2020 Apr 16.

From the Pediatric Emergency/Trauma Center Saint Joseph Children's Hospital and Medical Center; and Vascular and Interventional Radiology Florida Hospital Carollwood, Tampa, FL.

Objective: The purpose of the study, was to assess the utility of rapid sequence brain magnetic resonance imaging (RS-MRI), as a screening tool to detect gross intracranial pathology in children that present to the emergency department, with a chief complaint of persistent or recurrent headaches. Rapid sequence MRI of the brain is a radiation-free technique that is used to evaluate ventricular size in children with shunted hydrocephalus, who present to the emergency department with symptomatology consistent with shunt malfunction.

Methods: The study evaluated RS-MRI radiographic findings of 105 children that presented to a busy tertiary care pediatric emergency/trauma center between May 1, 2013, and May 31, 2015. Read More

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http://dx.doi.org/10.1097/PEC.0000000000002089DOI Listing

The effect of mTOR inhibition on obstructive hydrocephalus in patients with tuberous sclerosis complex (TSC) related subependymal giant cell astrocytoma (SEGA).

J Neurooncol 2020 May 13;147(3):731-736. Epub 2020 Apr 13.

Division of Haematology/Oncology, Department of Paediatrics, The Hospital for Sick Children, 555 University Avenue, Toronto, M5G 1X8, Canada.

Purpose: Mammalian target of rapamycin inhibitors (mTORi) are known to effectively reduce the size of subependymal giant cell astrocytomas (SEGAs), which are benign brain lesions associated with Tuberous Sclerosis Complex (TSC) that commonly cause obstructive hydrocephalus (OH). This retrospective case series reviews an institutional experience of the effect of mTORi on OH in patients with TSC-related SEGA.

Methods: Thirteen of 16 identified patients with TSC-related SEGA treated with mTORi from October 2007 to December 2018 were included. Read More

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http://dx.doi.org/10.1007/s11060-020-03487-8DOI Listing

Neuro-Oncology Practice Clinical Debate: targeted therapy vs conventional chemotherapy in pediatric low-grade glioma.

Neurooncol Pract 2020 Jan 13;7(1):4-10. Epub 2019 Aug 13.

Department of Pediatrics, University of California, San Francisco.

The treatment of children with low-grade glioma has evolved over the last several decades, beginning initially with focal radiotherapy, which has now been largely replaced by systemic treatment with conventional chemotherapy agents or more recently molecularly targeted therapeutics. A consensus standard of care is not well defined, leaving clinicians and parents to choose from an increasing number of options, often without complete information concerning the associated risks and benefits. Issues critical to this topic include timing of interventions (when to treat), preservation of neurological function (goals of treatment), choice of initial therapy strategy (conventional cytotoxic chemotherapy vs molecularly targeted therapy), duration of treatment (how long, and what clinical or imaging endpoints to consider), and perhaps most important, risk reduction relative to anticipated benefit. Read More

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http://dx.doi.org/10.1093/nop/npz033DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7104878PMC
January 2020

MRI Follow-up of Astrocytoma: Automated Coregistration and Color-Coding of FLAIR Sequences Improves Diagnostic Accuracy With Comparable Reading Time.

J Magn Reson Imaging 2020 Apr 4. Epub 2020 Apr 4.

Institute for Diagnostic and Interventional Radiology, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.

Background: MRI follow-up is widely used for longitudinal assessment of astrocytoma, yet reading can be tedious and error-prone, in particular when changes are subtle.

Purpose/hypothesis: To determine the effect of automated, color-coded coregistration (AC) of fluid attenuated inversion recovery (FLAIR) sequences on diagnostic accuracy, certainty, and reading time compared to conventional follow-up MRI assessment of astrocytoma patients.

Study Type: Retrospective. Read More

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http://dx.doi.org/10.1002/jmri.27136DOI Listing

Expanded transnasal approaches to the skull base in the Middle East: Where do we stand?

Ann Saudi Med 2020 Mar-Apr;40(2):94-104. Epub 2020 Apr 2.

From the Division of Neurosurgery, College of Medicine, King Saud University, Riyadh, Saudi Arabia.

Background: Endoscopic transnasal surgery has gained rapid global acceptance over the last two decades. The growing literature and understanding of anterior skull base endoscopic anatomy, in addition to new dedicated endoscopic instruments and tools, have helped to expand the use of the transnasal route in skull base surgery.

Objective: Report our early experience in expanded endoscopic transnasal surgery (EETS) and approach to skull base neoplasms. Read More

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http://dx.doi.org/10.5144/0256-4947.2020.94DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7118227PMC
April 2020
0.705 Impact Factor

Superficial Siderosis Associated with Long-Term Recurrence of Pilocytic Astrocytoma in an Elderly Person.

World Neurosurg 2020 Jun 27;138:541-544.e1. Epub 2020 Mar 27.

Department of Neurosurgery, Graduate School of Medical Science, Kanazawa University, Kanazawa, Ishikawa, Japan.

Background: Superficial siderosis is an irreversible disease in the central nervous system caused by the deposition of hemosiderin in the subpial tissue due to persistent bleeding in the subarachnoid space. The main symptoms include sensorineural hearing loss, cerebellar ataxia, and pyramidal tract disorder. Superficial siderosis is mainly idiopathic, but bleeding factors such as tumors or history of surgery often play an important role in its pathogenesis. Read More

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http://dx.doi.org/10.1016/j.wneu.2020.03.112DOI Listing

Novel Use of Subcostal Polyethylene Bands to Manage Tumor-Related Scoliosis Requiring Serial Imaging: A Case Report.

JBJS Case Connect 2020 Jan-Mar;10(1):e0351

Departments of Orthopaedic Surgery and Neurosurgery, Shriners Hospitals for Children-Philadelphia, Philadelphia, Pennsylvania.

Case: A 16-year-old male patient with severe kyphoscoliosis, paraplegia, and neurogenic bowel/bladder caused by a juvenile pilocytic astrocytoma was treated surgically using a hybrid fusion construct with polyethylene bands after neoplasm resection. Owing to the necessity of serial postoperative magnetic resonance imaging studies to evaluate the recurrence of pathology and known effect of metal artifact from spinal instrumentation, preservation of radiographic resolution was critical.

Conclusion: We describe the novel utility of polyethylene bands placed around the ribs as a safe and effective form of hybrid construct for reducing radiographic metal artifact in spinal deformity cases requiring serial imaging. Read More

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http://dx.doi.org/10.2106/JBJS.CC.19.00351DOI Listing

Image-based metric of invasiveness predicts response to adjuvant temozolomide for primary glioblastoma.

PLoS One 2020 27;15(3):e0230492. Epub 2020 Mar 27.

Mathematical NeuroOncology Laboratory, Precision Neurotherapeutics Innovation Program, Mayo Clinic, Phoenix, Arizona, United States of America.

Background: Temozolomide (TMZ) has been the standard-of-care chemotherapy for glioblastoma (GBM) patients for more than a decade. Despite this long time in use, significant questions remain regarding how best to optimize TMZ therapy for individual patients. Understanding the relationship between TMZ response and factors such as number of adjuvant TMZ cycles, patient age, patient sex, and image-based tumor features, might help predict which GBM patients would benefit most from TMZ, particularly for those whose tumors lack O6-methylguanine-DNA methyltransferase (MGMT) promoter methylation. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0230492PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7100932PMC

HSP70/IL-2 Treated NK Cells Effectively Cross the Blood Brain Barrier and Target Tumor Cells in a Rat Model of Induced Glioblastoma Multiforme (GBM).

Int J Mol Sci 2020 Mar 25;21(7). Epub 2020 Mar 25.

Department of Stem Cells and Developmental Biology, Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, ACECR, Tehran 16635-148, Iran.

Natural killer (NK) cell therapy is one of the most promising treatments for Glioblastoma Multiforme (GBM). However, this emerging technology is limited by the availability of sufficient numbers of fully functional cells. Here, we investigated the efficacy of NK cells that were expanded and treated by interleukin-2 (IL-2) and heat shock protein 70 (HSP70), both in vitro and in vivo. Read More

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http://dx.doi.org/10.3390/ijms21072263DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7178276PMC
March 2020
2.862 Impact Factor

Young Girl With Headache.

Ann Emerg Med 2020 04;75(4):e21-e22

Division of Emergency Medicine, Boston Children's Hospital, Boston, MA.

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http://dx.doi.org/10.1016/j.annemergmed.2019.10.023DOI Listing

Textiloma Mimicking a Recurrent High-Grade Astrocytoma: A Case Report.

J Neurol Surg Rep 2020 Jan 22;81(1):e7-e9. Epub 2020 Mar 22.

Department of Neuro-Oncology, Aurora Cancer Care, Milwaukee, Wisconsin, United States.

 Textiloma (Txm) is a nonmedical term that has been given to foreign body-related inflammatory pseudotumor arising from retained nonabsorbable cotton matrix that is either inadvertently or deliberately left behind during surgery, which may trigger an inflammatory reaction. This report describes a case of Txm mimicking a recurrent high-grade astrocytoma.  We, here, present the case of a 69-year-old female with a 6-month history of progressive left-sided weakness. Read More

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http://dx.doi.org/10.1055/s-0039-3400231DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7085942PMC
January 2020

T2-FLAIR mismatch sign in dysembryoplasticneuroepithelial tumor.

Eur J Radiol 2020 May 2;126:108924. Epub 2020 Mar 2.

Department of Neurosurgery, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan. Electronic address:

Purpose: T2-FLAIR mismatch sign was reported as specific imaging marker in non-enhancing diffuse astrocytoma, IDH-mutant & 1p/19q non-codeleted. However, most of the previous studies for T2-FLAIR mismatch sign were confirmed only among lower grade glioma. The aim of this study is to assess the T2-FLAIR mismatch sign in dysembryoplastic neuroepithelial tumor (DNET) and unveil the exception rules of the sign. Read More

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http://dx.doi.org/10.1016/j.ejrad.2020.108924DOI Listing
May 2020
2.369 Impact Factor

FASN Is a Biomarker Enriched in Malignant Glioma-Derived Extracellular Vesicles.

Int J Mol Sci 2020 Mar 12;21(6). Epub 2020 Mar 12.

Department of Neurosurgery, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.

Extracellular vesicles (EVs) are known for their important role in cancer progression and hold considerable potential as a source for tumor biomarkers. However, purification of tumor-specific EVs from patient plasma is still an urgent unmet need due to contamination by normal host cell-derived EVs, that results in compromised analytical sensitivity. Here we identified fatty acid synthase (FASN), a key lipogenic enzyme which is highly expressed in malignant glioma cells, to be elevated in CD63- and CD81-positive EVs in glioma patient plasma samples, opening vital opportunities to sort brain tumor-specific EVs. Read More

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http://dx.doi.org/10.3390/ijms21061931DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7139767PMC

Involvement of the Olfactory Apparatus by Gliomas.

AJNR Am J Neuroradiol 2020 04 12;41(4):712-717. Epub 2020 Mar 12.

Radiology (S.C.).

The olfactory bulbs and tracts are central nervous system white matter tracts maintained by central neuroglia. Although rare, gliomas can originate from and progress to involve the olfactory apparatus. Through a Health Insurance Portability and Accountability Act-compliant retrospective review of the institutional teaching files and brain MR imaging reports spanning 10 years, we identified 12 cases of gliomas involving the olfactory bulbs and tracts, including 6 cases of glioblastoma, 2 cases of anaplastic oligodendroglioma, and 1 case each of pilocytic astrocytoma, diffuse (grade II) astrocytoma, anaplastic astrocytoma (grade III), and diffuse midline glioma. Read More

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http://dx.doi.org/10.3174/ajnr.A6471DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7144643PMC

Segmentation and Classification in Digital Pathology for Glioma Research: Challenges and Deep Learning Approaches.

Front Neurosci 2020 21;14:27. Epub 2020 Feb 21.

Cancer Imaging Program, National Cancer Institute, National Institutes of Health, Bethesda, MD, United States.

Biomedical imaging Is an important source of information in cancer research. Characterizations of cancer morphology at onset, progression, and in response to treatment provide complementary information to that gleaned from genomics and clinical data. Accurate extraction and classification of both visual and latent image features Is an increasingly complex challenge due to the increased complexity and resolution of biomedical image data. Read More

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http://dx.doi.org/10.3389/fnins.2020.00027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7046596PMC
February 2020

Surgical Management of Intramedullary Spinal Cord Tumors.

Neurosurg Clin N Am 2020 Apr 31;31(2):237-249. Epub 2020 Jan 31.

Department of Neurological Surgery, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA; Department of Neurological Surgery, Weill Cornell Medical College, 525 E. 68th St, New York, NY 10065, USA.

Intramedullary spinal cord tumors (IMSCT) comprise a rare subset of CNS tumors that have distinct management strategies based on histopathology. These tumors often present challenges in regards to optimal timing for surgery, invasiveness, and recurrence. Advances in microsurgical techniques and technological adjuncts have improved extent of resection and outcomes with IMSCT. Read More

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http://dx.doi.org/10.1016/j.nec.2019.12.004DOI Listing

Fetal subependymal giant cell astrocytoma: A case report and review of the literature.

Surg Neurol Int 2020 25;11:26. Epub 2020 Feb 25.

Departments of Neurosurgery, Children's Hospital "Aghia Sofia", Athens, Greece.

Background: Subependymal giant cell astrocytomas (SEGAs) appear approximately in 10% of patients with tuberous sclerosis. These tumors are most commonly diagnosed in childhood and adolescence, with diagnosed SEGAs being an extremely rare entity.

Case Description: We present the case of a congenital SEGA detected in an antenatal ultrasound and further investigated with fetal magnetic resonance imaging (MRI) scans at 22 and 32 weeks of gestational age. Read More

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http://dx.doi.org/10.25259/SNI_10_2019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7049878PMC
February 2020

Machine Learning Decision Tree Models for Differentiation of Posterior Fossa Tumors Using Diffusion Histogram Analysis and Structural MRI Findings.

Front Oncol 2020 7;10:71. Epub 2020 Feb 7.

Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, United States.

We applied machine learning algorithms for differentiation of posterior fossa tumors using apparent diffusion coefficient (ADC) histogram analysis and structural MRI findings. A total of 256 patients with intra-axial posterior fossa tumors were identified, of whom 248 were included in machine learning analysis, with at least 6 representative subjects per each tumor pathology. The ADC histograms of solid components of tumors, structural MRI findings, and patients' age were applied to construct decision models using Classification and Regression Tree analysis. Read More

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http://dx.doi.org/10.3389/fonc.2020.00071DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7018938PMC
February 2020

Avoiding New Biopsies by Identification of IDH1 and TERT Promoter Mutation in Nondiagnostic Biopsies From Glioma Patients.

Neurosurgery 2020 Feb 28. Epub 2020 Feb 28.

Centre de recherche en Cancérologie de Lyon, INSERM U1052, CNRS UMR 5286, Cancer Cell Plasticity department, Transcriptome Diversity in Stem Cells laboratory, Lyon, France.

Background: Biopsies in patients with a suspected glioma are occasionally nondiagnostic.

Objective: To explore the utility of molecular testing in this setting by determining whether IDH1 and TERT promoter (pTERT) mutations could be detected in nondiagnostic biopsies from glioma patients.

Methods: Using SNaPshot polymerase chain reaction, we retrospectively assessed IDH1 and pTERT mutation status in nondiagnostic biopsies from 28 glioma patients. Read More

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http://dx.doi.org/10.1093/neuros/nyaa025DOI Listing
February 2020