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EClinicalMedicine 2022 Jul 27;49:101466. Epub 2022 May 27.

Department of Cardiology, Shanghai Children's Medical Centre, Shanghai Jiao Tong University School of Medicine, Shanghai 200127, China.

Background: Few data on paediatric hypertrophic cardiomyopathy (HCM) are available in developing countries. A multicentre, retrospective, cohort study was conducted to profile the clinical characteristics and survival of children with HCM in China.

Methods: We collected longitudinal data on children with HCM aged 0-18 years at three participating institutions between January 1, 2010 and December 31, 2019. Read More

Cureus 2022 Jun 18;14(6):e26067. Epub 2022 Jun 18.

Cardiology, Lincoln Medical Center, New York City, USA.

Hypertrophic cardiomyopathy (HCM) is the most prevalent genetic cardiac disease while apical hypertrophic cardiomyopathy (apHCM) is a rare subset of HCM. The significance of this case report is to present apHCM, its chronological course, and its association with left ventricular aneurysm, thrombosis, and cardiac arrest. We present the case of a 56-year-old female with a past medical history of apHCM who was admitted for substernal chest pain, developed a ventricular storm (VT), and subsequently suffered cardiac arrest; resuscitation of spontaneous circulation (ROSC) was eventually achieved after 10 minutes. Read More

J Cardiovasc Dev Dis 2022 May 25;9(6). Epub 2022 May 25.

National Cerebral and Cardiovascular Center, Department of Cardiovascular Medicine, Suita 564-8565, Japan.

Hypertrophic cardiomyopathy (HCM) is an underdiagnosed genetic heart disease with an estimated prevalence of 0.2-0.5%. Read More

Int J Cardiol 2022 Jun 16. Epub 2022 Jun 16.

MD, Unité médico-chirurgicale de cardiologie congénitale et pédiatrique, centre de référence des maladies cardiaques congénitales complexes - M3C, Hôpital universitaire Necker-Enfants Malades, Université de Paris, France and Azienda Ospedaliero Universitaria Meyer, Florence, Italy. Electronic address:

Background: Clinical and prognostic role of cardiac magnetic resonance (CMR) in adult population with hypertrophic cardiomyopathy (HCM) have been largely assessed. We sought to investigate the role of CMR for predicting cardiovascular events in children with HCM.

Methods: CMR was performed in 116 patients with HCM (37 sarcomeric mutations, 31 other mutations, mean age 10. Read More

J Magn Reson Imaging 2022 Jun 17. Epub 2022 Jun 17.

Department of Radiology, Functional and Molecular Imaging Key Laboratory of Sichuan Province, West China Hospital, Sichuan University, Chengdu, Sichuan, China.

Background: Obesity is highly prevalent in patients with hypertrophic cardiomyopathy (HCM) and believed to influence its phenotype.

Purpose: To explore the effects of obesity on left ventricular (LV) remodeling and long-term clinical course in Chinese patients with HCM.

Study Type: Longitudinal. Read More

Sci Rep 2022 Jun 17;12(1):10186. Epub 2022 Jun 17.

Unit of Medical Physics, Pisa University Hospital "Azienda Ospedaliero-Universitaria Pisana", Via Roma 67, 56126, Pisa, Italy.

Radiomics is emerging as a promising and useful tool in cardiac magnetic resonance (CMR) imaging applications. Accordingly, the purpose of this study was to investigate, for the first time, the effect of image resampling/discretization and filtering on radiomic features estimation from quantitative CMR T1 and T2 mapping. Specifically, T1 and T2 maps of 26 patients with hypertrophic cardiomyopathy (HCM) were used to estimate 98 radiomic features for 7 different resampling voxel sizes (at fixed bin width), 9 different bin widths (at fixed resampling voxel size), and 7 different spatial filters (at fixed resampling voxel size/bin width). Read More

Clin Sports Med 2022 Jul;41(3):425-440

Sports & Performance Cardiology Program, MedStar Health, 3333 North Calvert Street Suite 500 JPB, Baltimore, MD 21218, USA. Electronic address:

Routine vigorous exercise can lead to electrical, structural, and functional adaptations that can enhance exercise performance. There are several factors that determine the type and magnitude of exercise-induced cardiac remodeling (EICR) in trained athletes. In some athletes with pronounced cardiac remodeling, there can be an overlap in morphologic features with mild forms of cardiomyopathy creating gray zone scenarios whereby distinguishing health from disease can be difficult. Read More

Med Phys 2022 Jun 15. Epub 2022 Jun 15.

Utah Center for Advanced Imaging Research (UCAIR), Department of Radiology and Imaging Sciences, University of Utah, Salt Lake City, Utah, USA.

Background: Using the spin-lattice relaxation time (T1) as a biomarker, the myocardium can be quantitatively characterized using cardiac T1 mapping. The modified Look-Locker inversion (MOLLI) recovery sequences have become the standard clinical method for cardiac T1 mapping. However, the MOLLI sequences require an 11-heartbeat breath-hold that can be difficult for subjects, particularly during exercise or pharmacologically induced stress. Read More

PLoS One 2022 13;17(6):e0269807. Epub 2022 Jun 13.

Heart and Vascular Center, Semmelweis University, Budapest, Hungary.

Background: While patients with cardiac transthyretin amyloidosis are easily diagnosed with bone scintigraphy, the detection of cardiac light chain (AL) amyloidosis is challenging. Cardiac magnetic resonance (CMR) analyses play an essential role in the differential diagnosis of cardiomyopathies; however, limited data are available from cardiac AL-Amyloidosis. Hence, the purpose of the present study was to analyze the potential role of CMR in the detection of cardiac AL-amyloidosis. Read More

J Cardiovasc Magn Reson 2022 Jun 13;24(1):36. Epub 2022 Jun 13.

Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford Centre for Clinical Magnetic Resonance Research (OCMR), University of Oxford, John Radcliffe Hospital, Headley Way, Oxford, OX3 9DU, UK.

Background: The right ventricle (RV) in hypertrophic cardiomyopathy (HCM) tends to be neglected, as previous efforts have predominantly focused on examining the prognostic value of left ventricular (LV) abnormalities. The objectives of this study were to assess RV function in HCM, changes over time, and association with clinical outcomes.

Methods: Two hundred and ninety HCM patients with preserved LV ejection fraction (LVEF ≥ 55%) and 30 age- and sex-matched controls underwent cardiovascular magnetic resonance (CMR). Read More

J Clin Med 2022 Jun 1;11(11). Epub 2022 Jun 1.

Institute for Radiology, Nuclear Medicine and Molecular Imaging, Herz-und Diabeteszentrum NRW, Ruhr-Universität Bochum, 32545 Bad Oeynhausen, Germany.

The present study aims to evaluate magnetic-resonance-imaging (MRI)-assessed left atrial strain (LAS) and left atrial strain rate (LASR) as potential parameters for the diagnosis of cardiac amyloidosis (CA), the distinction of clinical subtypes and differentiation from other cardiomyopathies. LAS and LASR were assessed by MRI feature tracking in patients with biopsy-proven CA. LAS and LASR of patients with CA were compared to healthy subjects and patients with hypertrophic cardiomyopathy. Read More

Eur Heart J Cardiovasc Imaging 2022 Jun 7. Epub 2022 Jun 7.

Department of Cardiology, Room Rg-419, Thoraxcenter, Erasmus MC, University Medical Center Rotterdam, Dr. Molewaterplein 40, Rotterdam 3015 GD, The Netherlands.

Aims: Genetic testing in relatives of hypertrophic cardiomyopathy (HCM) patients leads to early identification of pathogenic DNA variant carriers (G+), before the onset of left ventricular hypertrophy. Routine phenotyping consists of electrocardiography (ECG) and transthoracic echocardiography (TTE). Cardiovascular magnetic resonance (CMR) has become valuable in the work-up of HCM. Read More

Radiol Case Rep 2022 Aug 28;17(8):2598-2602. Epub 2022 May 28.

Department of Magnetic Resonance Imaging, Fuwai Hospital and National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beilishi Road No. 167, Xicheng District, Beijing 100037, China.

Cor triatriatum dexter (CTD) is an extremely rare congenital cardiac malformation in which a membrane divides the right atrium into 2 chambers. Hypertrophic cardiomyopathy (HCM) with restrictive phenotype is also a rare cardiomyopathy. We report a case with an 18-year history of chest discomfort, fatigue and syncope following intense physical activity was finally diagnosed with CTD complicated with HCM, and the HCM is a special type, restrictive phenotype. Read More

J Am Soc Echocardiogr 2022 Jun;35(6):533-569

Toronto General Hospital, Toronto, Canada.

Hypertrophic cardiomyopathy (HCM) is defined by the presence of left ventricular hypertrophy in the absence of other potentially causative cardiac, systemic, syndromic, or metabolic diseases. Symptoms can be related to a range of pathophysiologic mechanisms including left ventricular outflow tract obstruction with or without significant mitral regurgitation, diastolic dysfunction with heart failure with preserved and heart failure with reduced ejection fraction, autonomic dysfunction, ischemia, and arrhythmias. Appropriate understanding and utilization of multimodality imaging is fundamental to accurate diagnosis as well as longitudinal care of patients with HCM. Read More

Monaldi Arch Chest Dis 2021 Dec 30;92(3). Epub 2021 Dec 30.

Cardiology Unit at Emergency Department, Madonna del Soccorso Hospital, San Benedetto del Tronto.

Hypertrophic cardiomyopathy (HCM) is a genetic disorder presenting with a pathological increase of left ventricle (LV) wall thicknesses. The most frequent morphological form is characterized by an abnormal LV basal septal hypertrophy. Tako-Tsubo cardiomyopathy (TTC) is a transient left ventricular systolic dysfunction induced by high physical or emotional stress. Read More

Eur Heart J Cardiovasc Imaging 2022 Jun 3. Epub 2022 Jun 3.

Department of Cardiology and Nephrology, Mie University Graduate School of Medicine, Tsu, Mie, Japan.

Am J Med 2022 May 29. Epub 2022 May 29.

HCM Center at Lahey Hospital and Medical Center, Burlington, MA.

PURPOSE;: To determine whether clinicians are encountering a phenotype of hypertrophic cardiomyopathy evolving from the disease recognized several years ago.

Methods: 3, 161 consecutive patients encountered with established hypertrophic cardiomyopathy (2003-2020), studied clinically and with imaging.

Results: Patients were identified as progressively older now (average 56 ± 15 years) compared to 44 ± 17 years previously (p<0. Read More

PLoS One 2022 1;17(6):e0269019. Epub 2022 Jun 1.

Division of Cardiovascular Medicine, Department of Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.

Background: This study aimed to determine the etiology of stage-D heart failure (HF) and the prevalence and prognosis of misdiagnosed cardiomyopathy in patients undergoing heart transplantation.

Methods And Results: We retrospectively reviewed 127 consecutive patients (mean age, 42 years; 90 [71%], male) from February 1994 to September 2021 admitted for heart transplant in our tertiary center. Pre-transplant clinical diagnosis was compared with post-transplant pathological diagnosis. Read More

Comput Cardiol (2010) 2021 Sep 10;2021. Epub 2022 Jan 10.

Chester F. Carlson Center for Imaging Science, Rochester Institute of Technology, Rochester, NY, USA.

Faithful, accurate, and successful cardiac biomechanics and electrophysiological simulations require patient-specific geometric models of the heart. Since the cardiac geometry consists of highly-curved boundaries, the use of high-order meshes with curved elements would ensure that the various curves and features present in the cardiac geometry are well-captured and preserved in the corresponding mesh. Most other existing mesh generation techniques require computer-aided design files to represent the geometric boundary, which are often not available for biomedical applications. Read More

Front Cardiovasc Med 2022 11;9:865615. Epub 2022 May 11.

Department of Cardiology, Cardiovascular Imaging Center, The Second Affiliated Hospital of Harbin Medical University, Harbin, China.

Background: The differentiation between hypertrophic cardiomyopathy (HCM) and hypertensive heart disease (HHD) is challenging due to similar myocardial hypertrophic phenotype. The purpose of this study is to evaluate the feasibility of cardiovascular magnetic resonance feature tracking (CMR-FT) and late gadolinium enhancement (LGE) to distinguish between HCM and HHD and the potential relationship between myocardial strain and cardiac functional parameters.

Methods: One hundred and seventy subjects (57 HCM, 45 HHD, and 68 controls) underwent 3. Read More

Am J Cardiol 2022 Aug 26;176:125-131. Epub 2022 May 26.

Peter Munk Cardiac Centre, Toronto General Hospital, University Health Network, Toronto, Ontario, Canada.

In this study, we aimed to assess a large cohort of nonapical hypertrophic cardiomyopathy (HC) patients who have undergone 2 serial cardiac magnetic resonance studies to examine morphological dynamics and their correlation to patient characteristics and clinical outcomes. A total of 214 patients with nonapical HC were enrolled in this study, with 2 sequential cardiac magnetic resonance studies separated by a mean interval of 4.8 ± 2. Read More

Rev Esp Anestesiol Reanim (Engl Ed) 2022 05 25;69(5):317-318. Epub 2022 May 25.

Department of Anesthesia and Perioperative Medicine, Western University-London Health Sciences Centre, London (Ontario), Canada.

Diagnostics (Basel) 2022 Apr 28;12(5). Epub 2022 Apr 28.

Department of Cardiology, Institute of Medical Sciences, University of Opole, 45-401 Opole, Poland.

Patients with nonclassic phenotypes (NCP)-more advanced stages of hypertrophic cardiomyopathy (HCM)-constitute an intriguing and heterogeneous group that is difficult to diagnose, risk-stratify, and treat, and often neglected in research projects. We aimed to compare cardiac magnetic resonance (CMR) parameters in NCP versus classic phenotypes (CP) of HCM with special emphasis given to the parameters of established and potential prognostic importance, including numerous variables not used in everyday clinical practice. The CMR studies of 88 patients performed from 2011 to 2019 were postprocessed according to the study protocol to obtain standard and non-standard parameters. Read More

Diagnostics (Basel) 2022 Apr 19;12(5). Epub 2022 Apr 19.

Congenital Heart Disease and Pediatric Cardiology, German Heart Center Munich, Technical University of Munich, 80636 Munich, Germany.

Cardiomyopathies (CMPs) are a heterogeneous group of diseases that involve the myocardium and result in systolic or diastolic impairment of the cardiac muscle, potentially leading to heart failure, malignant arrhythmias, or sudden cardiac death. Occurrence in pediatric age is rare but has been associated with worse outcomes. Non-invasive cardiac imaging techniques, integrated with clinical, genetic, and electrocardiographic data, have shown a pivotal role in the clinical work-up of such diseases by defining structural alterations and assessing potential complications. Read More

J Imaging 2022 May 23;8(5). Epub 2022 May 23.

Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN 55902, USA.

The analysis and interpretation of cardiac magnetic resonance (CMR) images are often time-consuming. The automated segmentation of cardiac structures can reduce the time required for image analysis. Spatial similarities between different CMR image types were leveraged to jointly segment multiple sequences using a segmentation model termed a multi-image type UNet (MI-UNet). Read More

J Cardiovasc Dev Dis 2022 Apr 21;9(5). Epub 2022 Apr 21.

Department of Pediatrics, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, 416 85 Gothenburg, Sweden.

Sudden cardiac death due to hypertrophic cardiomyopathy (HCM), is the most common autopsy-proven cause of unexpected medical death in children after infancy. This mode of death is preventable by implantation of an internal cardiac defibrillator (ICD), a procedure that has considerable morbidity in childhood patients, and even mortality. Since HCM is an inheritable disease (usually autosomal dominant, occasionally recessive), family screening may identify subjects at risk. Read More

Arq Bras Cardiol 2022 05;118(5):873-874

Faculdade de Medicina de Ribeirão Preto - USP, São Paulo, SP - Brasil.

Circ Cardiovasc Interv 2022 Jun 23;15(6):e012106. Epub 2022 May 23.

Emory Structural Heart and Valve Center, Emory University, Atlanta, GA (A.B.G., G.S.H., P.T.G., E.K.I., R.A.G., G.P., V.C.B.).

BMC Cardiovasc Disord 2022 May 21;22(1):235. Epub 2022 May 21.

Department of Radiology, West China Hospital, Sichuan University, No. 37 Guo Xue Xiang, Chengdu, 610041, Sichuan, China.

Background: To elucidate the value of texture analysis (TA) in detecting and differentiating myocardial tissue alterations on T2-weighted CMR (cardiovascular magnetic resonance imaging) in patients with cardiac amyloidosis (CA) and hypertrophic cardiomyopathy (HCM).

Methods: In this retrospective study, 100 CA (58.5 ± 10. Read More

Circ Cardiovasc Imaging 2022 May 17;15(5):e000077. Epub 2022 May 17.