1,195 results match your criteria Imaging in Hyperaldosteronism


New-Onset Atrial Fibrillation in Patients With Primary Aldosteronism Receiving Different Treatment Strategies: Systematic Review and Pooled Analysis of Three Studies.

Front Endocrinol (Lausanne) 2021 24;12:646933. Epub 2021 May 24.

Department of Internal Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan.

Background: Primary aldosteronism (PA) is a common cause of secondary hypertension and associated with higher incidence of new-onset atrial fibrillation (NOAF). However, the effects of surgical or medical therapies on preventing NOAF in PA patents remain unclear. The aim of this meta-analysis study was to assess the risk of NOAF among PA patients receiving mineralocorticoid receptor antagonist (MRA) treatment, PA patients receiving adrenalectomy, and patients with essential hypertension. Read More

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Should Adrenal Venous Sampling Be Performed in PA Patients Without Apparent Adrenal Tumors?

Front Endocrinol (Lausanne) 2021 12;12:645395. Epub 2021 Apr 12.

Department of Endocrinology and Metabolism, National Hospital Organization Kyoto Medical Center, Kyoto, Japan.

Introduction: Some aldosterone-producing micro-adenomas cannot be detected through image inspection. Therefore, adrenal venous sampling (AVS) is often performed, even in primary aldosteronism (PA) patients who have no apparent adrenal tumors (ATs) on imaging. In most of these cases, however, the PA is bilateral. Read More

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Adrenal Incidentaloma.

Authors:
Electron Kebebew

N Engl J Med 2021 Apr;384(16):1542-1551

From the Division of General Surgery, Department of Surgery, Stanford University School of Medicine, Stanford, CA.

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Enhanced Ca signaling, mild primary aldosteronism, and hypertension in a familial hyperaldosteronism mouse model ( ).

Proc Natl Acad Sci U S A 2021 Apr;118(17)

Department of Nephrology, Charité-Universitätsmedizin Berlin, 10115 Berlin, Germany;

Gain-of-function mutations in the gene (encoding the T-type calcium channel Ca3.2) cause autosomal-dominant familial hyperaldosteronism type IV (FH-IV) and early-onset hypertension in humans. We used CRISPR/Cas9 to generate knockin mice as a model of the most common FH-IV mutation, along with corresponding knockout mice ( ). Read More

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Prevalence, Subtype Classification, and Outcomes of Treatment of Primary Aldosteronism: A Prospective Study in China.

Endocr Pract 2021 May 14;27(5):478-483. Epub 2020 Dec 14.

Center of Laboratory Medicine, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People's Republic of China. Electronic address:

Objective: To investigate the prevalence of primary aldosteronism (PA) among participants with hypertension, evaluate the concordance of PA classification between adrenal computed tomography and adrenal venous sampling, and compare the outcomes of surgery and medication for unilateral PA.

Methods: A prospective study was conducted among all inpatients with hypertension (n = 7594) at the National Center for Cardiovascular Diseases, China, from May 2016 to April 2018.

Results: Of the 7594 participants, 8. Read More

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Pearls & Oy-sters: Cerebral Microbleeds Caused by Adrenocortical Adenoma-Related Primary Aldosteronism.

Neurology 2021 05 7;96(20):960-962. Epub 2021 Apr 7.

From the Departments of Neurology (S.M.L., S.Y.M.), Endocrinology (Y.J.C.), Ophthalmology (K.L.), Thyroid Endocrinology Surgery (H.K.K.), Cardiology (J.-S.P.), Neurosurgery (Y.C.L.), and Pathology (J.-H.K.), Ajou University School of Medicine; and Department of Medical Sciences (S.M.L.), Graduate School of Ajou University, Suwon, Republic of Korea.

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A Rare Cause of Refractory Severe Polyhydramnios: Antenatal Bartter Syndrome.

Medicina (Kaunas) 2021 Mar 16;57(3). Epub 2021 Mar 16.

Department of Obstetrics and Gynecology, Ewha Womans University School of Medicine, Seoul 07804, Korea.

: Antenatal Bartter syndrome is an autosomal recessive disorder causing severe polyuria that leads to severe polyhydramnios and preterm labor. Prenatal diagnosis of antenatal Bartter syndrome is difficult because the genetic diagnosis can only be confirmed following a clinical diagnosis in infants. Reports of prenatal diagnosis and treatment of antenatal Bartter syndrome are limited. Read More

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Feasibility of Iodine-131 6β-Methyl-Iodo-19 Norcholesterol (NP-59) Scintigraphy to Complement Adrenal Venous Sampling in Management of Primary Aldosteronism: A Case Series.

Int J Gen Med 2021 1;14:673-680. Epub 2021 Mar 1.

Division of Endocrinology and Metabolism, Department of Internal Medicine, Eunpyeong St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.

Purpose: Primary aldosteronism (PA) is mainly comprised of aldosterone-producing adenoma and bilateral idiopathic adrenal hyperplasia. Current guidelines recommend adrenal venous sampling (AVS) as a gold standard method to classify the subtypes. However, because of technical challenges in AVS including invasiveness of AVS and a wide range of success rate for cannulation, it is not uncommon that appropriate decisions could not be made depending on AVS. Read More

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[Hyperaldosteronism].

Authors:
U I Scholl

Internist (Berl) 2021 Mar 18;62(3):245-251. Epub 2021 Feb 18.

Medizinische Klinik mit Schwerpunkt Nephrologie und Internistische Intensivmedizin, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Charitéplatz 1, 10117, Berlin, Deutschland.

Aldosterone is produced in the adrenal cortex and governs volume and electrolyte homeostasis. Hyperaldosteronism can occur either as primary aldosteronism (renin-independent) or secondary aldosteronism (renin-dependent). As the commonest cause of secondary hypertension, primary aldosteronism is associated with increased cardiovascular risk. Read More

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Functional imaging by 11C-metomidate PET: a really useless technique for primary aldosteronism subtyping?

Eur J Endocrinol 2021 Mar;184(3):L9-L10

Internal Medicine Emergency Unit, Specialized Hypertension Centre of Regione Veneto, Department of Medicine - DIMED, University of Padova, Padova, Italy.

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Spindle Cell Hemangioma and Atypically Localized Juxtaglomerular Cell Tumor in a Patient with Hereditary BRIP1 Mutation: A Case Report.

Genes (Basel) 2021 Feb 3;12(2). Epub 2021 Feb 3.

Department of Pediatrics, University Hospital Brno, 613 00 Brno, Czech Republic.

Spindle cell hemangioma is a benign vascular tumor typically occurring in the dermis or subcutis of distal extremities as red-brown lesions that can grow in both size and number over time. They can be very painful and potentially disabling. A family history of cancer or previous history may be relevant and must be taken into consideration. Read More

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February 2021

Quadriplegia and rhabdomyolysis as a presenting feature of Conn's syndrome.

BMJ Case Rep 2021 Jan 25;14(1). Epub 2021 Jan 25.

Endocrinology, Kasturba Medical College, Manipal, Manipal Academy of Higher Education, MAHE, Manipal, Karnataka, India

Conn's syndrome is an important endocrine cause for secondary hypertension. Hypokalaemia paralysis and rhabdomyolysis with accelerated hypertension may be the presenting symptoms of Conn's syndrome. Here, we present one such case of a 38-year-old woman presenting with accelerated hypertension and acute onset quadriplegia. Read More

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January 2021

Exploration Of The Seated Saline Suppression Test For The Diagnosis Of Primary Aldosteronism In The Chinese Population.

Endocr Pract 2020 Aug;26(8):891-899

From the Department of Endocrinology and Metabolism, Adrenal Center, West China Hospital, Sichuan University, Chengdu, Sichuan, China. Electronic address:

Objective: We prospectively investigated the accuracy of the seated saline suppression test (SSST) in 113 patients with hypertension (including 93 primary aldosteronism [PA] and 20 essential hypertension patients) in the Department of Endocrinology and Metabolism.

Methods: Each patient underwent a recumbent saline suppression test (RSST) and SSST. The accuracy of the SSST for a confirmative PA diagnosis and subtype classification was evaluated and compared with the RSST. Read More

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Diagnostic accuracy of adrenal imaging for subtype diagnosis in primary aldosteronism: systematic review and meta-analysis.

BMJ Open 2020 12 31;10(12):e038489. Epub 2020 Dec 31.

Cardiology, Clinical Medical College and The First Affiliated Hospital of Chengdu Medical College, Chengdu, Sichuan, China

Objectives: Accurate subtype classification in primary aldosteronism (PA) is critical in assessing the optimal treatment options. This study aimed to evaluate the diagnostic accuracy of adrenal imaging for unilateral PA classification.

Methods: Systematic searches of PubMed, EMBASE and the Cochrane databases were performed from 1 January 2000 to 1 February 2020, for all studies that used CT or MRI in determining unilateral PA and validated the results against invasive adrenal vein sampling (AVS). Read More

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December 2020

Approach to the Patient with Primary Aldosteronism: Utility and Limitations of Adrenal Vein Sampling.

J Clin Endocrinol Metab 2021 Mar;106(4):1195-1208

Division of Metabolism, Endocrinology, and Diabetes, Ann Arbor, Michigan, USA.

Several studies over the past 3 decades document a higher prevalence of primary aldosteronism (PA) among hypertensive patients than generally presumed. PA exists as a spectrum from mild to severe aldosterone excess. Although a variety of PA subtypes exist, the 2 most common are aldosterone-producing adenomas (APAs) and bilateral hyperaldosteronism (BHA). Read More

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Functional imaging of adrenal cortex.

Rev Esp Med Nucl Imagen Mol (Engl Ed) 2020 Nov - Dec;39(6):393-404. Epub 2020 Oct 21.

Servicio de Medicina Nuclear, Hospital Universitario y Politécnico La Fe, Valencia, España.

The rising number of high-resolution imaging scans has increased the adrenal lesions detection, which require a differential diagnosis. Currently, the most commonly used scans are CT and MRI, but these are sometimes not very specific. In these cases, nuclear medicine scans with I-norcolesterol, C-metomidate and F-fludeoxyglucose help to differentiate benign vs. Read More

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October 2020

The diagnostic accuracy of adjusted unconventional indices for adrenal vein sampling in the diagnosis of primary aldosteronism subtypes.

J Hypertens 2021 May;39(5):1025-1033

Endocrinology, Diabetes and Metabolism, City of Health and Science University Hospital, Department of Medical Sciences, University of Turin, Turin.

Objective: Simple unconventional indices did not demonstrate a satisfactory accuracy for diagnosing unilateral primary aldosteronism when adrenal vein sampling is not bilaterally selective. This study aimed to evaluate the reliability of clinical/imaging-corrected unconventional indices for adrenal vein sampling in predicting unilateral primary aldosteronism.

Methods: Data of all consecutive patients with primary aldosteronism subtyped with adrenal vein sampling, referred to two Italian centers, were analyzed retrospectively. Read More

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Association of Adrenal Venous Sampling With Outcomes in Primary Aldosteronism for Unilateral Adenomas.

JAMA Surg 2021 Feb;156(2):165-171

Department of Surgery, Weill Cornell Medical College, New York-Presbyterian Hospital, New York.

Importance: Adrenal venous sampling is recommended prior to adrenalectomy for all patients with hyperaldosteronism; however, cross-sectional imaging resolution continues to improve, while the procedure remains invasive and technically difficult. Therefore, certain patients may benefit from advancing straight to surgery.

Objective: To determine whether clinical and biochemical resolution varied for patients with primary aldosteronism with unilateral adenomas who underwent adrenal venous sampling vs those who proceeded to surgery based on imaging alone. Read More

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February 2021

CACNA1H Calcium Channel Mutations in Primary Aldosteronism - Is Sodium the Culprit?

Endocrinology 2020 12;161(12)

Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Department of Nephrology and Medical Intensive Care, Berlin, Germany.

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December 2020

Prediction of hyperaldosteronism subtypes when adrenal vein sampling is unilaterally successful.

Eur J Endocrinol 2020 Dec;183(6):657-667

Division of Internal Medicine and Hypertension, Department of Medical Sciences, University of Torino, Torino, Italy.

Objective: Adrenal venous sampling (AVS) is the gold standard to discriminate patients with unilateral primary aldosteronism (UPA) from bilateral disease (BPA). AVS is technically demanding and in cases of unsuccessful cannulation of adrenal veins, the results may not always be interpreted. The aim of our study was to develop diagnostic models to distinguish UPA from BPA, in cases of unilateral successful AVS and the presence of contralateral suppression of aldosterone secretion. Read More

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December 2020

A highly unusual case of osmotic demyelination syndrome and extrapontine myelinolysis in a 3-month-old infant with Bartter syndrome.

J Int Med Res 2020 Oct;48(10):300060520966494

Child Neuropsychiatry, Obstetric and Pediatric Department, Azienda USL-IRCCS di Reggio Emilia, Reggio Emilia, Italy.

Bartter syndrome (BS) is a rare autosomal recessive renal tubular disorder characterized by acute electrolyte imbalance, and similarly, osmotic demyelination syndrome (ODS) is a rather rare complication occurring during electrolyte imbalance. The pathological features of ODS include central pontine myelinolysis and extrapontine myelinolysis (EPM), which consist of severe damage to the myelin sheath of neurons. ODS is very rare in children. Read More

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October 2020

Functional imaging with 11C-metomidate PET for subtype diagnosis in primary aldosteronism.

Eur J Endocrinol 2020 Dec;183(6):539-550

Endocrinology, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.

Objective: Endocrine Society guidelines recommend adrenal venous sampling (AVS) in primary aldosteronism (PA) if adrenalectomy is considered. We tested whether functional imaging of adrenal cortex with 11C-metomidate (11C-MTO) could offer a noninvasive alternative to AVS in the subtype classification of PA.

Design: We prospectively recruited 58 patients with confirmed PA who were eligible for adrenal surgery. Read More

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December 2020

Adrenal Venous Sampling-Guided Adrenalectomy Rates in Primary Aldosteronism: Results of an International Cohort (AVSTAT).

J Clin Endocrinol Metab 2021 Mar;106(3):e1400-e1407

Division of Diabetes and Endocrinology, National International Center for Global Health and Medicine, Tokyo, Japan.

Context: Adrenal venous sampling (AVS) is the current criterion standard lateralization technique in primary aldosteronism (PA). Japanese registry data found that 30% of patients with unilateral PA did not undergo adrenalectomy, but the reasons for this and whether the same pattern is seen internationally are unknown.

Objective: To assess the rate of AVS-guided adrenalectomy across an international cohort and identify factors that resulted in adrenalectomy not being performed in otherwise eligible patients. Read More

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A speckle-tracking echocardiographic study on right ventricular function in primary aldosteronism.

J Hypertens 2020 11;38(11):2152-2153

Department of Translational and Precision Medicine, "Sapienza" University of Rome, Rome, Italy.

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November 2020

[Clinical characteristics of primary aldosteronism with concurrent adrenal Cushing's syndrome].

Zhonghua Yi Xue Za Zhi 2020 Sep;100(36):2828-2833

Department of Endocrinology, Peking University First Hospital, Beijing 100034, China.

To analyze and summarize the clinical characteristics of primary aldosteronism (PA) with concurrent adrenal Cushing's syndrome (ACS). The clinical, imaging and pathological data of 87 patients with PA admitted to Peking University First Hospital from January 1st, 2013 to December 31th, 2016 were reviewed. There were 45 males (51. Read More

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September 2020

Primary Aldosteronism: New Insights Into its Detection and Cardiac Involvement.

JACC Cardiovasc Imaging 2020 10 16;13(10):2160-2161. Epub 2020 Sep 16.

Department of Medicine, University of Michigan School of Medicine, Ann Arbor, Michigan.

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October 2020

Aldosterone-Related Myocardial Extracellular Matrix Expansion in Hypertension in Humans: A Proof-of-Concept Study by Cardiac Magnetic Resonance.

JACC Cardiovasc Imaging 2020 10 16;13(10):2149-2159. Epub 2020 Sep 16.

Department of Radiology, Hôpital Européen Georges-Pompidou, Assistance Publique-Hôpitaux de Paris, Paris, France; Department of Hypertension, Hôpital Européen Georges-Pompidou, Assistance Publique-Hôpitaux de Paris, Paris, France; Department of Biological & Statistic, Hôpital Européen Georges-Pompidou, Assistance Publique-Hôpitaux de Paris, Paris, France; Université de Paris, Paris, France; Paris Cardiovascular Research Center, French Institute of Health and Medical Research, Paris, France. Electronic address:

Objectives: This study sought to assess the respective effects of aldosterone and blood pressure (BP) levels on myocardial fibrosis in humans.

Background: Experimentally, aldosterone promotes left ventricular (LV) hypertrophy, and interstitial myocardial fibrosis in the presence of high salt intake.

Methods: The study included 20 patients with primary aldosteronism (PA) (high aldosterone and high BP), 20 patients with essential hypertension (HTN) (average aldosterone and high BP), 20 patients with secondary aldosteronism due to Bartter/Gitelman (BG) syndrome (high aldosterone and normal BP), and 20 healthy subjects (HS) (normal aldosterone and normal BP). Read More

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October 2020

Primary Hyperaldosteronism in End-Stage Renal Disease: Diagnostic Challenges and Treatment Considerations.

Cureus 2020 Aug 7;12(8):e9599. Epub 2020 Aug 7.

Endocrinology and Diabetes, Center for Endocrinology and Diabetes, Shreveport, USA.

An adrenal incidentaloma is defined as an adrenal mass measuring at least 1 cm that is discovered surreptitiously in an imaging study done for reasons other than the evaluation of adrenal disease. The increase in the prevalence of adrenal incidentalomas has paralleled the increase in diagnostic imaging done for evaluation of other abdominal pathologies. However, most of these adrenal incidentalomas are benign non-hyperfunctioning adenomas. Read More

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Taiwan mini-frontier of primary aldosteronism: Updating detection and diagnosis.

J Formos Med Assoc 2021 Jan 24;120(1 Pt 1):121-129. Epub 2020 Aug 24.

Division of Endocrinology, Department of Internal Medicine, Taipei Tzu-Chi Hospital, Buddhist Tzu-Chi Medical Foundation, New Taipei City, Taiwan; School of Medicine, Tzu-Chi University, Hualien, Taiwan. Electronic address:

Background: To update information about the internationally accepted standards and clinical recommendations for the detection and diagnosis of primary aldosteronism (PA).

Methods: The Taiwan Society of Aldosteronism (TSA) Task Force reviewed the latest literature and reached a consensus after group meetings. The nine critical issues were recognized to provide updated information and internationally acceptable protocols. Read More

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January 2021