1,297 results match your criteria Imaging in Hyperaldosteronism


Familial Hyperaldosteronism Type 3 with a Rapidly Growing Adrenal Tumor: An In Situ Aldosterone Imaging Study.

Curr Issues Mol Biol 2021 Dec 28;44(1):128-138. Epub 2021 Dec 28.

Department of Urology and Andrology, Kansai Medical University, Osaka 573-1191, Japan.

Primary aldosteronism is most often caused by aldosterone-producing adenoma (APA) and bi-lateral adrenal hyperplasia. Most APAs are caused by somatic mutations of various ion channels and pumps, the most common being the inward-rectifying potassium channel . Germ line mutations of cause familial hyperaldosteronism type 3 (FH3), which is associated with severe hyperaldosteronism and hypertension. Read More

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December 2021

11C-Metomidate PET-CT versus adrenal vein sampling to subtype primary aldosteronism: a prospective clinical trial.

J Hypertens 2022 Jun;40(6):1179-1188

Yong Loo Lin School of Medicine, National University of Singapore (NUS).

Objective: Adrenal vein sampling (AVS) is recommended to subtype primary aldosteronism, but it is technically challenging. We compared 11C-Metomidate-PET-computed tomography (PET-CT) and AVS for subtyping of primary aldosteronism.

Methods: Patients with confirmed primary aldosteronism underwent both AVS and 11C-Metomidate PET-CT (post-dexamethasone). Read More

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Radiomics utilization to differentiate nonfunctional adenoma in essential hypertension and functional adenoma in primary aldosteronism.

Sci Rep 2022 May 25;12(1):8892. Epub 2022 May 25.

Division of Cardiology, Department of Internal Medicine, National Taiwan University Hospital, National Taiwan University College of Medicine, Taipei, Taiwan.

We performed the present study to investigate the role of computed tomography (CT) radiomics in differentiating nonfunctional adenoma and aldosterone-producing adenoma (APA) and outcome prediction in patients with clinically suspected primary aldosteronism (PA). This study included 60 patients diagnosed with essential hypertension (EH) with nonfunctional adenoma on CT and 91 patients with unilateral surgically proven APA. Each whole nodule on unenhanced and venous phase CT images was segmented manually and randomly split into training and test sets at a ratio of 8:2. Read More

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Autonomous cortisol secretion is associated with worse arterial stiffness and vascular fibrosis in primary aldosteronism: a cross-sectional study with follow-up data.

Eur J Endocrinol 2022 Jun 7;187(1):197-208. Epub 2022 Jun 7.

Division of Cardiology, Department of Internal Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan.

Objective: The presence of autonomous cortisol secretion (ACS) in patients with primary aldosteronism (PA) is common and potentially associated with poor outcomes. The aim of this study was to investigate the association between ACS and vascular remodeling in PA patients.

Design And Methods: We prospectively enrolled 436 PA patients from October 2006 to November 2019. Read More

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Early Renin Recovery After Adrenalectomy in Aldosterone-Producing Adenomas: A Prospective Study.

Horm Metab Res 2022 Apr 12;54(4):224-231. Epub 2022 Apr 12.

Department of Internal Medicine, University of Sao Paulo, Ribeirao Preto, SP, Brazil.

The aim of the study was to clarify the relationship and the time of aldosterone and renin recoveries at immediate and long-term follow-up in aldosterone-producing adenoma (APA) patients who underwent adrenalectomy. Prospective and longitudinal protocol in a cohort of APA patients was followed in a single center. Among 43 patients with primary aldosteronism (PA), thirteen APA patients were enrolled in this study. Read More

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Accurate lesion localisation facilitates nephron sparing surgery in reninoma patients: case report and discussion.

Urol Case Rep 2022 Jul 25;43:102069. Epub 2022 Mar 25.

Monash Health Department of Urology, 62-70 Kangan Drive, Berwick, VIC, 3806, Australia.

A 21-year-old female was referred with a suspected juxtaglomerular cell tumour (reninoma) in the superior pole of the left kidney. She underwent renal biopsy and renal vein sampling (RVS) to confirm the diagnosis. Following an uncomplicated laparoscopic partial nephrectomy, antihypertensive medications were ceased. Read More

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Integration of molecular imaging in the personalized approach of patients with adrenal masses.

Q J Nucl Med Mol Imaging 2022 Jun 28;66(2):104-115. Epub 2022 Mar 28.

Division of Endocrine and Metabolic Surgery, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy.

Adrenal masses are a frequent finding in clinical practice. Many of them are incidentally discovered with a prevalence of 4% in patients undergoing abdominal anatomic imaging and require a differential diagnosis. Biochemical tests, evaluating hormonal production of both adrenal cortex and medulla (in particular, mineralocorticoids, glucocorticoids and catecholamines), have a primary importance in distinguishing functional or non-functional lesions. Read More

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Discordant imaging-adrenal vein sampling in almost half of patients with primary aldosteronism and a unilateral adrenal adenoma.

Intern Med J 2022 Mar 23. Epub 2022 Mar 23.

Department of Endocrinology, North Shore Hospital, Waitematā District Health Board.

Background: Primary hyperaldosteronism (PHA) is an underdiagnosed cause of secondary hypertension, with an increased risk of cardiovascular and renal complications compared to those with essential hypertension alone. Distinguishing between unilateral and bilateral aldosterone secretion is important as management differs. Adrenal vein sampling (AVS) is the gold standard for determining lateralisation. Read More

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KCNJ5 Somatic Mutation Is Associated With Higher Aortic Wall Thickness and Less Calcification in Patients With Aldosterone-Producing Adenoma.

Front Endocrinol (Lausanne) 2022 2;13:830130. Epub 2022 Mar 2.

Department of Business Administration and Graduate School of Service Management, Chihlee University of Technology, New Taipei City, Taiwan.

Objective: Primary aldosteronism (PA) is the most common type of secondary hypertension, and it is associated with a higher rate of cardiovascular complications. KCNJ5 somatic mutations have recently been identified in aldosterone-producing adenoma (APA), however their influence on vascular remodeling and injury is still unclear. The aim of this study was to investigate the association between KCNJ5 somatic mutation status and vascular status. Read More

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A case of atypical reninoma with mild hypertension and normal plasma renin activity but elevated plasma renin concentration.

BMC Endocr Disord 2022 Mar 18;22(1):71. Epub 2022 Mar 18.

Department of Endocrinology and Metabolism, Tianjin Medical University General Hospital, Tianjin, China.

Background: Reninoma is a rare, benign renal neoplasm. Typical clinical features include severe hypertension, secondary hyperaldosteronism, hypokalaemia and metabolic alkalosis caused by the overproduction of renin.

Case Presentation: A 25-year-old lean Chinese woman with no family history of hypertension was hospitalized for stage 1 hypertension that gradually developed over two years. Read More

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Primary hyperaldosteronism induces congruent alterations of sodium homeostasis in different skeletal muscles: a 23Na-MRI study.

Eur J Endocrinol 2022 Mar 29;186(5):K33-K38. Epub 2022 Mar 29.

University and University Hospital Würzburg, Comprehensive Heart Failure Center, Würzburg, Germany.

Background: Sodium homeostasis is disrupted in many cardiovascular diseases, which makes non-invasive sodium storage assessment desirable. In this regard, sodium MRI has shown its potential to reveal differences in sodium content between healthy and diseased tissues as well as treatment-related changes of sodium content. When different tissues are affected disparately, simultaneous assessment of these compartments is expected to provide better information about sodium distribution, reduce examination time, and improve clinical efficiency. Read More

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The Accuracy of Simple and Adjusted Aldosterone Indices for Assessing Selectivity and Lateralization of Adrenal Vein Sampling in the Diagnosis of Primary Aldosteronism Subtypes.

Front Endocrinol (Lausanne) 2022 16;13:801529. Epub 2022 Feb 16.

Endocrinology, Diabetes and Metabolism, Department of Medical Sciences, City of Health and Science University Hospital, University of Turin, Turin, Italy.

Objective: This study aimed to evaluate the reliability of simple and corrected aldosterone indices for assessing the selectivity and lateralization of adrenal vein sampling (AVS) in patients with primary aldosteronism.

Methods: Data of all consecutive patients with primary aldosteronism who underwent AVS for subtype diagnosis, followed at two Italian referral centers, were analyzed retrospectively.

Results: AVS achieved bilateral selectivity in 112/144 patients. Read More

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The Relationship Between Renal Stones and Primary Aldosteronism.

Front Endocrinol (Lausanne) 2022 9;13:828839. Epub 2022 Feb 9.

Department of Urology, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan.

Introduction: The association between primary aldosteronism (PA) and nephrolithiasis is still unclear. The hypercalciuria and hypocitraturia of PA patients might be the reason leading to recurrent calcium nephrolithiasis. This study aimed to evaluate the relationship between PA and renal stones, including stone size and density. Read More

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Recent Advances in the Clinical Application of Adrenal Vein Sampling.

Front Endocrinol (Lausanne) 2022 9;13:797021. Epub 2022 Feb 9.

Department of Endocrine and Metabolic Diseases, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.

We reviewed clinical research investigating the applications of adrenal vein sampling (AVS). AVS could be applied not only to primary aldosteronism (PA) but also to other endocrine diseases, such as adrenocorticotropic hormone (ACTH) independent Cushing syndrome (AICS) and hyperandrogenemia (HA). However, the AVS protocol requires improvements to increase its success rate. Read More

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Primary Aldosteronism: Imaging vs. Lateralization.

Authors:
John W Funder

Am J Hypertens 2022 Jun;35(6):512-513

Hudson Institute (Steroid Biology) and Monash University, Clayton, Victoria, Australia.

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[Diagnosis and therapy of primary aldosteronism: new aspects].

Dtsch Med Wochenschr 2022 Jan 31;147(3):92-97. Epub 2022 Jan 31.

Primary aldosteronism represents the most frequent cause of endocrine hypertension. It is associated with a higher morbidity and mortality compared to essential hypertension. Early identification of the affected patients is crucial, as the adequate therapy leads to an excellent long-term prognosis, especially after unilateral adrenalectomy. Read More

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January 2022

Diabetes mellitus is associated with worse baseline and less post-treatment recovery of arterial stiffness in patients with primary aldosteronism.

Ther Adv Chronic Dis 2022 13;13:20406223211066727. Epub 2022 Jan 13.

Division of Cardiology, Department of Internal Medicine, National Taiwan University Hospital, College of Medicine, National Taiwan University, No. 7, Chung-Shan South Road, Taipei 100 Cardiovascular Center, National Taiwan University Hospital, Taipei.

Background: Aldosterone excess in primary aldosteronism (PA) has been linked to insulin resistance, and diabetes mellitus has been associated with increased arterial stiffness and worse cardiovascular outcomes. However, the impact of diabetes on baseline and post-treatment arterial stiffness in patients with PA is unknown.

Methods: This study prospectively enrolled 1071 PA patients, of whom 177 had diabetes and 894 did not. Read More

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January 2022

Prognosis of adrenalectomy guided by computed tomography versus adrenal vein sampling in patients with primary aldosteronism: A systematic review and meta-analysis.

J Clin Hypertens (Greenwich) 2022 02 22;24(2):106-115. Epub 2022 Jan 22.

Beijing An Zhen Hospital, Capital Medical University, Beijing, China.

Adrenal vein sampling (AVS) is recommended to be the gold standard for patients with unilateral subtypes of primary aldosteronism to clinical diagnosis and surgery therapy. However, it is uncertain whether AVS is better for prognosis than computed tomography (CT), which is the most widely used. Pubmed, Embase, and Cochrane Library were searched for articles with no start date restriction. Read More

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February 2022

Visualization of calcium channel blockers in human adrenal tissues and their possible effects on steroidogenesis in the patients with primary aldosteronism (PA).

J Steroid Biochem Mol Biol 2022 04 12;218:106062. Epub 2022 Jan 12.

Department of Pathology, Tohoku University Graduate School of Medicine, Sendai, Japan.

Voltage-gated L-type calcium channel (CaV) isoforms are well known to play pivotal tissue-specific roles not only in vasoconstriction but also in adrenocortical steroidogenesis including aldosterone biosynthesis. Alpha-1C subunit calcium channel (CC) (CaV1.2) is the specific target of anti-hypertensive CC blockers (CCBs) and its Alpha-1D subunit (CaV1. Read More

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A case with primary hyperaldosteronism associated with chronic kidney disease.

Radiol Case Rep 2022 Mar 16;17(3):558-562. Epub 2021 Dec 16.

Department of Surgery, Biomedical Engineering, and Physiology, Mayo Clinic, Rochester, MN, USA.

Primary hyperaldosteronism (PA) is one of the most common causes of secondary hypertension. PA may be associated with a decline in renal function. About 20% of cases with resistant HTN eventually cause PA, so all these patients should be evaluated for PA. Read More

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Catecholamine-induced cardiomyopathy: an endocrinologist's perspective.

Rev Cardiovasc Med 2021 Dec;22(4):1215-1228

Department of Endocrinology and Metabolism, Pilgrim Hospital, PE21 9QS Boston, UK.

Although many endocrine diseases can be associated with acquired cardiomyopathy and heart failure, conditions except hypothyroidism, hyperthyroidism, phaeochromocytoma-paraganglioma (PPGL), and primary hyperaldosteronism are rare. PPGL is a rare catecholamine-secreting neuroendocrine tumour arising from the adrenal gland in 80-85% or extra-adrenal chromaffin cells of the autonomic neural ganglia in the remainder. The annual incidence of PPGL is 3-8 cases per million per year in the general population. Read More

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December 2021

A revised mechanism of action of hyperaldosteronism-linked mutations in cytosolic domains of GIRK4 (KCNJ5).

J Physiol 2022 03 17;600(6):1419-1437. Epub 2022 Jan 17.

Department of Physiology and Pharmacology, School of Medicine, and Sagol School of Neuroscience, Tel Aviv University, Tel Aviv, Israel.

G protein-gated, inwardly rectifying potassium channels (GIRK) mediate inhibitory transmission in brain and heart, and are present in the adrenal cortex. GIRK4 (KCNJ5) subunits are abundant in the heart and adrenal cortex. Multiple mutations of KCNJ5 cause primary aldosteronism (PA). Read More

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Is it Possible to Assess the Functional Status of Hormone Secretion or Non-secretion of Adrenal Masses Through Their Magnetic Resonance Imaging (MRI) Characteristics?

Endocr Metab Immune Disord Drug Targets 2021 12 19. Epub 2021 Dec 19.

Cukurova University, Faculty of Medicine, Division of Endocrinology, Adana, Turkey.

Background: Diagnostic imaging techniques including magnetic resonance imaging (MRI) should also perform on all patients with incidentalomas. However, there is a limited study whether the quantitative measurements (signal intensity index, adrenal to spleen ratio) in MRI could predict the functional status of adrenal adenomas.

Material-method: Between 2015-2020; 404 patients (265 females, 139 males) with adrenal mass who were referred to the university hospital for further investigation were included. Read More

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December 2021

Techniques in adrenal vein sampling: Multipurpose catheter shape facilitates sampling of cranially oriented right adrenal veins.

Diagn Interv Radiol 2022 Jan;28(1):79-82

Division of Interventional Radiology, Department of Radiology, Hospital of the University of Pennsylvania, Philadelphia, USA.

Adrenal vein sampling (AVS) failure is often attributed to difficulty sampling the right adrenal vein (RAV). Normally, the RAV is caudally oriented, however, cranial orientation of the RAV is not uncommon. In such cases, use of a multipurpose (MPA) catheter shape may facilitate sampling. Read More

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January 2022

Morphologically Normal-Appearing Adrenal Glands as a Prevalent Source of Aldosterone Production in Primary Aldosteronism.

Am J Hypertens 2022 Jun;35(6):561-571

Center for Adrenal Disorders, Division of Endocrinology, Diabetes, and Hypertension, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.

Background: Normal-appearing adrenal glands on cross-sectional imaging may still be the source of aldosterone production in primary aldosteronism (PA).

Methods: We evaluated the prevalence of aldosterone production among morphologically normal-appearing adrenal glands and the impact of this phenomenon on interpretations of localization studies and treatment decisions. We performed a retrospective cohort study of PA patients with at least 1 normal adrenal gland and reanalyzed contemporary studies to assess interpretations of imaging and adrenal venous sampling (AVS) at the individual patient and adrenal levels. Read More

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Enhanced performance of a modified diagnostic test of primary aldosteronism in patients with adrenal adenomas.

Eur J Endocrinol 2022 Jan 6;186(2):265-273. Epub 2022 Jan 6.

Department of Endocrinology, Diabetes and Metabolic Diseases, Henry Dunant Hospital Center, Athens, Greece.

Objective: Primary aldosteronism (PA) is the commonest cause of endocrine hypertension ranging from 4.6 to 16.6% according to the diagnostic tests employed. Read More

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January 2022

Feasibility of Imaging-Guided Adrenalectomy in Young Patients With Primary Aldosteronism.

Hypertension 2022 01 17;79(1):187-195. Epub 2021 Nov 17.

3rd Department of Medicine, Charles University Prague, General Hospital, Czech Republic (J.W., Z.K.).

Many of the patients with primary aldosteronism (PA) are denied curative adrenalectomy because of limited availability or failure of adrenal vein sampling. It has been suggested that adrenal vein sampling can be omitted in young patients with a unilateral adrenal nodule, who show a florid biochemical PA phenotype. As this suggestion was based on a very low quality of evidence, we tested the applicability and accuracy of imaging, performed by computed tomography and/or magnetic resonance, for identification of unilateral PA, as determined by biochemical and/or clinical cure after unilateral adrenalectomy. Read More

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January 2022

A Prospective Comparative Study on Cardiac Alterations After Surgery and Drug Treatment of Primary Aldosteronism.

Front Endocrinol (Lausanne) 2021 11;12:770711. Epub 2021 Nov 11.

Department of Cardiovascular Medicine, National Research Center for Translational Medicine, Centre for Cardiovascular Evaluations, Shanghai Key Laboratory of Hypertension, The Shanghai Institute of Hypertension, Department of Hypertension, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.

Background: Current guideline recommends both surgery and drug treatment for primary aldosteronism. Treatment effects on the cardiac structure and function remain under investigation.

Objective: We performed a prospective study in patients with primary aldosteronism to compare effects of surgery and drug treatment on the cardiac structure and function as assessed by the left ventricular (LV) pressure-strain loop, a novel echocardiographic technique that incorporates myocardial deformation and LV pressure. Read More

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February 2022

Positive Association Between Plasma Aldosterone Concentration and White Matter Lesions in Patients With Hypertension.

Front Endocrinol (Lausanne) 2021 18;12:753074. Epub 2021 Nov 18.

Hypertension Center of People's Hospital of Xinjiang Uygur Autonomous Region, Xinjiang Hypertension Institute, National Health Committee Key Laboratory of Hypertension Clinical Research, Key Laboratory of Xinjiang Uygur Autonomous Region "Hypertension Research Laboratory", Xinjiang Clinical Medical Research Center for Hypertension (Cardio-Cerebrovascular) Diseases, Urumqi, China.

Background And Objective: White matter lesions (WMLs) are imaging changes in MRI of cerebral small vessel disease associated with vascular risk factors, increasing the risk of dementia, depression, and stroke. Aldosterone (ALD) or activation of mineralocorticoid receptor (MR) causes cerebrovascular injury in a mouse model. We aimed to analyze the relationship between ALD and WMLs in a population with hypertension. Read More

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February 2022

Long-term mortality and cardiovascular events in patients with unilateral primary aldosteronism after targeted treatments.

Eur J Endocrinol 2021 Dec 20;186(2):195-205. Epub 2021 Dec 20.

Department of Urology, National Taiwan University Hospital, Taipei, Taiwan.

Objective: Long-term outcomes (especially mortality and/or major cardiovascular events (MACE)) of the unilateral primary aldosteronism (uPA) patients who underwent medical or surgery-targeted treatment, relative to those with essential hypertension (EH), have been scarcely reported.

Design And Settings: Using the prospectively designed observational Taiwan Primary Aldosteronism Investigation cohort, we identified 858 uPA cases among 1220 primary aldosteronism patients and another 1210 EH controls.

Exposures: Operated uPA patients were grouped via their 1-year post-therapy statuses. Read More

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December 2021