1,148 results match your criteria Imaging in Herpes Encephalitis


Ramsay Hunt syndrome with pontine lesion: A case report.

Medicine (Baltimore) 2019 Feb;98(5):e14260

Department of Neurological Function Examination.

Rationale: The coexistence of Ramsay Hunt syndrome (RHS) and varicella-zoster virus (VZV) encephalitis is rare. A patient who developed RHS after being infected with VZV, along with a pontine lesion, is reported in the present study.

Patient Concerns: A 41-year-old male patient presented with his mouth askew for 7 days, and dizziness, accompanied by hearing loss for 3 days. Read More

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http://dx.doi.org/10.1097/MD.0000000000014260DOI Listing
February 2019
1 Read
5.723 Impact Factor

Mouse model of anti-NMDA receptor post-herpes simplex encephalitis.

Neurol Neuroimmunol Neuroinflamm 2019 Mar 26;6(2):e529. Epub 2018 Dec 26.

Center for Systems Biology (CSB), Department of Neurology (J.L., R.N.), Massachusetts General Hospital (MGH); CSB, Department of Radiology (B.P., S.S., M.Z.), MGH, Boston; Neuroimmunology Program (T.A.), Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Hospital Clínic, Universitat de Barcelona; Pediatric Neuroimmunology Unit (T.A.), Neurology Department, Sant Joan de Déu Children's Hospital, University of Barcelona; Neuroimmunology Program (J.P., J.D.), IDIBAPS, Barcelona, Spain; Department of Neurology (J.D.), University of Pennsylvania, PA; Catalan Institute for Research and Advanced Studies (ICREA) (J.D.), Barcelona, Spain; and Institute for Innovation in Imaging (J.C.), Department of Radiology, MGH, Boston.

Objective: To develop an endogenous rodent model of postinfectious anti-NMDA receptor (NMDAR) encephalitis.

Methods: Six mice were inoculated intranasally with herpes simplex virus (HSV) 1 and subsequently treated with acyclovir for 2 weeks. Serum was collected at 3, 6, and 8 weeks postinoculation and tested for NMDAR antibodies through a cell-based assay. Read More

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http://dx.doi.org/10.1212/NXI.0000000000000529DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6340334PMC
March 2019
1 Read

Cerebrovascular manifestations of herpes simplex virus infection of the central nervous system: a systematic review.

J Neuroinflammation 2019 Jan 29;16(1):19. Epub 2019 Jan 29.

Department of Neurology, Christian Doppler Medical Center, Paracelsus Medical University, Ignaz-Harrer-Str. 79, 5020, Salzburg, Austria.

Background: Intracerebral hemorrhage and ischemic stroke are increasingly recognized complications of central nervous system (CNS) infection by herpes simplex virus (HSV).

Aim Of The Study: To analyze clinical, imaging, and laboratory findings and outcomes of cerebrovascular manifestations of HSV infection.

Methods: Systematic literature review from January 2000 to July 2018. Read More

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http://dx.doi.org/10.1186/s12974-019-1409-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6352343PMC
January 2019
1 Read

An Adult Case of Herpes Simplex Virus-Associated Granulomatous Encephalitis.

Intern Med 2019 Jan 10. Epub 2019 Jan 10.

Department of Neurology, Graduate School of Medicine, Chiba University, Japan.

Brain granuloma occurs under certain conditions. Herpes simplex virus (HSV) causes granulomatous encephalitis in children; however, it has been rarely reported in adults. A 74-year-old man with a history of herpes simplex encephalitis suffered recurrent seizures. Read More

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http://dx.doi.org/10.2169/internalmedicine.2046-18DOI Listing
January 2019
1 Read

Japanese Encephalitis Virus-Induced Anti-N-Methyl-D-Aspartate Receptor Encephalitis: A Case Report and Review of Literature.

Neuropediatrics 2019 Jan 8. Epub 2019 Jan 8.

Department of Pediatrics, Zunyi Medical University, First Affiliated Hospital, Zunyi, Guizhou Province, China.

Anti-N-methyl-D-aspartate receptor encephalitis (anti-NMDARe) was originally described as a paraneoplastic disease with more than 50% cases involving a tumor. However, tumor incidence in anti-NMDARe in children is much lower. Herpes simplex virus-induced anti-NMDARe has been well-described; however, findings on Japanese encephalitis virus (JEV)-induced anti-NMDARe are scarce. Read More

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http://dx.doi.org/10.1055/s-0038-1675607DOI Listing
January 2019
3 Reads

Challenges in HSV encephalitis: normocellular CSF, unremarkable CCT, and atypical MRI findings.

Infection 2018 Dec 1. Epub 2018 Dec 1.

Department of Neurology, Klinikum der Ludwig-Maximilians-University (LMU) Munich, Marchioninistr. 15, 81377, Munich, Germany.

Purpose: Herpes simplex virus (HSV) encephalitis continues to be the most common form of sporadic lethal encephalitis worldwide. The wide spectrum of clinical presentations and laboratory findings often poses a diagnostic challenge for physicians which might delay administration of life-saving therapy with acyclovir. Atypical presentations of HSV encephalitis have become increasingly prevalent with better diagnostic techniques and have not been well studied. Read More

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http://link.springer.com/10.1007/s15010-018-1257-7
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http://dx.doi.org/10.1007/s15010-018-1257-7DOI Listing
December 2018
9 Reads

[A 64-year-old male with recurrence of herpes simplex encephalitis after suffering from severe pneumonia and sepsis].

Rinsho Shinkeigaku 2018 Dec 29;58(12):771-774. Epub 2018 Nov 29.

Department of Neurology, NTT Medical Center Tokyo.

The case is a 64-year-old male who had a past history of herpes simplex virus encephalitis (HSE) two years prior to his admission. He was admitted to our hospital due to severe pneumonia and sepsis. Several days later, he developed HSE again. Read More

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http://dx.doi.org/10.5692/clinicalneurol.cn-001226DOI Listing
December 2018
1 Read

Limbic encephalitis: Experience of a moroccan center.

Brain Behav 2019 Jan 25;9(1):e01177. Epub 2018 Nov 25.

Department of Neurology, Hassan II University Teaching Hospital, Fez, Morocco.

Objectives: Histologically defined as an inflammation-degeneration of limbic structures, limbic encephalitis (LE) is a rare disease and often difficult to diagnose particularly in institutions with limited access to laboratory tests such as antineuronal antibodies or HSV-PCR, and functional imaging. We aimed to describe the demographic, clinical, paraclinical, and etiological features of LE, as well as its medium-term prognosis in Moroccan patients.

Materials And Methods: We collected retrospectively all patients diagnosed with LE in the Department of Neurology of the University Hospital Hassan II of Fez (Morocco) between September 2008 and December 2016. Read More

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http://doi.wiley.com/10.1002/brb3.1177
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http://dx.doi.org/10.1002/brb3.1177DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346419PMC
January 2019
8 Reads

Clinical Correlations of Positive Herpes Simplex PCR in Cerebrospinal Fluid.

Neurologist 2018 Nov;23(6):204-208

Infectology, Raúl Carrea Institute for Neurological Research (FLENI).

Objectives: Herpes simplex viruses (HSV) can produce encephalitis (HSE), which requires early detection, typically using polymerase chain reaction (PCR) in cerebrospinal fluid (CSF). However, other neurological conditions not directly caused by HSV may also present with a positive HSV PCR in the CSF (NCNHPCR+). We aimed to analyze the clinical features of both groups of patients (HSE vs. Read More

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http://dx.doi.org/10.1097/NRL.0000000000000215DOI Listing
November 2018
5 Reads

Manifestations of Herpes Virus Infections in the Nervous System.

Neurol Clin 2018 Nov;36(4):725-738

Department of Neurology, Felsenstein Medical Research Institut, Rabin Medical Center, Beilinson Hospital, Beilinson Campus, Petach Tikva 49100, Israel; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 6997801, Israel.

The 3 neurotropic human herpes viruses, herpes simplex virus (HSV) type 1 and 2, and varicella-zoster virus (VZV) are capable of establishment of latent viral infection in trigeminal and dorsal root ganglia. HSV-1, and more rarely HSV-2, carries the potential to cause meningoencephalitis, with devastating clinical consequences. Immediate diagnosis, based on clinical presentation, MRI imaging, and molecular diagnosis by polymerase chain reaction, and initiation of therapy are mandatory to reduce mortality and neurologic permanent sequelae. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S07338619183123
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http://dx.doi.org/10.1016/j.ncl.2018.06.005DOI Listing
November 2018
18 Reads

Postseizure aphasia in Wernicke's encephalopathy: a case report and review of literature.

Neuropsychiatr Dis Treat 2018 8;14:2593-2598. Epub 2018 Oct 8.

Department of Psychiatry, Consultation-Liaison Psychiatry, Loyola University Medical Center, Maywood, IL 60153, USA,

This case discusses the course of a woman with a history of epilepsy, alcohol use disorder, herpes simplex virus (HSV) encephalitis, and Wernicke encephalopathy (WE) who presented with altered mental status following approximately 48 hours of vomiting. After experiencing a tonic-clonic seizure in the emergency department, she developed a fluent aphasia. Aphasias are ordinarily attributed to structural changes in the brain parenchyma, often from stroke, neoplasm, or infection. Read More

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http://dx.doi.org/10.2147/NDT.S174481DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6183589PMC
October 2018
17 Reads

A Fatal Case of Herpes Simplex Encephalitis with Two False-Negative Polymerase Chain Reactions.

Case Rep Neurol 2018 May-Aug;10(2):217-222. Epub 2018 Aug 29.

Department of Neurology, University of Iowa Hospitals and Clinics, Iowa City, Iowa, USA.

An 88-year-old man presented with a 1-month history of altered mental status and seizures. His electrographic and imaging findings were suggestive of herpes simplex encephalitis (HSE), for which he was empirically treated with acyclovir. He underwent two lumbar punctures 3 days apart; both cerebrospinal fluid analyses tested negative for herpes simplex virus (HSV) by polymerase chain reaction (PCR). Read More

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http://dx.doi.org/10.1159/000492053DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6167650PMC
August 2018
2 Reads

Herpesvirus Infections of the Nervous System.

Continuum (Minneap Minn) 2018 Oct;24(5, Neuroinfectious Disease):1349-1369

Purpose Of Review: This article reviews the spectrum of neurologic disease associated with human herpesvirus infections.

Recent Findings: As more patients are becoming therapeutically immunosuppressed, human herpesvirus infections are increasingly common. Historically, infections with human herpesviruses were described as temporal lobe encephalitis caused by herpes simplex virus type 1 or type 2. Read More

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http://dx.doi.org/10.1212/CON.0000000000000661DOI Listing
October 2018
10 Reads

Atypical development of neurosyphilis mimicking limbic encephalitis.

Int J STD AIDS 2018 Sep 26:956462418797873. Epub 2018 Sep 26.

1 Brain Research Laboratory, Department of Neurology, Ziv Medical Center, Safed, Israel.

A previously healthy 35-year-old man suffering from behavioral and mental deterioration for three months was referred to our facility. On admission, the patient was dysphasic and had tonic-clonic seizures. Neurological examination showed mental confusion, euphoric mood, mania, paranoia, and mild motor dysphasia. Read More

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http://journals.sagepub.com/doi/10.1177/0956462418797873
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http://dx.doi.org/10.1177/0956462418797873DOI Listing
September 2018
17 Reads

Acute Viral Encephalitis.

Authors:
Kenneth L Tyler

N Engl J Med 2018 Aug;379(6):557-566

From the Departments of Neurology, Medicine, and Immunology-Microbiology and the Section on Neuroinfectious Disease, University of Colorado School of Medicine, Aurora.

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http://dx.doi.org/10.1056/NEJMra1708714DOI Listing
August 2018
1 Read

Frequency, symptoms, risk factors, and outcomes of autoimmune encephalitis after herpes simplex encephalitis: a prospective observational study and retrospective analysis.

Lancet Neurol 2018 Sep 23;17(9):760-772. Epub 2018 Jul 23.

Neuroimmunology Program, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Hospital Clínic, University of Barcelona, Barcelona, Spain; Service of Neurology, Hospital Clínic, University of Barcelona, Barcelona, Spain; Department of Neurology, University of Pennsylvania, PA, USA; Catalan Institution for Research and Advanced Studies (ICREA), Barcelona, Spain. Electronic address:

Background: Herpes simplex encephalitis can trigger autoimmune encephalitis that leads to neurological worsening. We aimed to assess the frequency, symptoms, risk factors, and outcomes of this complication.

Methods: We did a prospective observational study and retrospective analysis. Read More

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http://dx.doi.org/10.1016/S1474-4422(18)30244-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6128696PMC
September 2018
21 Reads

A Case of Herpes Simplex Virus Type 1 (HSV-1) Encephalitis as a Possible Complication of Cosmetic Nasal Dermal Filler Injection.

Am J Case Rep 2018 Jul 13;19:825-828. Epub 2018 Jul 13.

Department of Radiology, Universiti Kebangsaan Malaysia Medical Center, Cheras, Malaysia.

BACKGROUND Dermal fillers are increasingly used for medical and aesthetic purposes in clinical practice. Common complications following filler injections include bruising, itching, infections, allergic reactions, and tissue necrosis. This case is the first report of Herpes simplex virus type 1 (HSV-1) encephalitis as a possible complication of dermal filler injection. Read More

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http://dx.doi.org/10.12659/AJCR.909883DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6066969PMC
July 2018
8 Reads

Teratoma-negative anti-NMDA receptor encephalitis presenting with a single generalized tonic-clonic seizure.

Epilepsy Behav Case Rep 2018 13;10:29-31. Epub 2018 Mar 13.

Department of Clinical Neurological Sciences, Western University, London, Ontario, Canada.

Herein, we describe a case report of anti-NMDA receptor encephalitis characterized by a single generalized tonic-clonic seizure and predominantly psychiatric symptoms, persisting long after EEG abnormalities had resolved. We discuss common presentations of anti-NMDA receptor encephalitis and advocate for the inclusion of this disease entity in the differential diagnosis of patients presenting with one generalized tonic-clonic seizure and prominent psychiatric symptoms. Read More

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http://dx.doi.org/10.1016/j.ebcr.2018.02.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6030023PMC
March 2018
6 Reads

A 20-Month-Old Girl With Fever, Seizures, Hemiparesis, and Brain Lesions Requiring a Diagnostic Brain Biopsy.

Semin Pediatr Neurol 2018 07 13;26:80-82. Epub 2017 Apr 13.

Department of Internal Medicine, University of Iowa Carver College of Medicine, Iowa City, IA.

We report a case of a 20-month-old girl with atypical presentation of a fairly common condition. She presented with acute onset of fever, seizures, and hemiparesis. Her cerebrospinal fluid showed total nucleated cells 10/mm with lymphocyte dominance. Read More

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http://dx.doi.org/10.1016/j.spen.2017.03.012DOI Listing

Magnetic resonance imaging of arterial stroke mimics: a pictorial review.

Insights Imaging 2018 Oct 22;9(5):815-831. Epub 2018 Jun 22.

Department of Diagnostic and Therapeutic Neuroradiology, Hôpital Purpan, Place du Docteur Baylac, TSA 40031, 31059, Toulouse, France.

Acute ischaemic stroke represents the most common cause of new sudden neurological deficit, but other diseases mimicking stroke happen in about one-third of the cases. Magnetic resonance imaging (MRI) is the best technique to identify those 'stroke mimics'. In this article, we propose a diagnostic approach of those stroke mimics on MRI according to an algorithm based on diffusion-weighted imaging (DWI), which can be abnormal or normal, followed by the results of other common additional MRI sequences, such as T2 with gradient recalled echo weighted imaging (T2-GRE) and fluid-attenuated inversion recovery (FLAIR). Read More

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http://dx.doi.org/10.1007/s13244-018-0637-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6206386PMC
October 2018
9 Reads

Neurological Disorders Associated with Human Alphaherpesviruses.

Authors:
Jun-Ichi Kawada

Adv Exp Med Biol 2018 ;1045:85-102

Department of Pediatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan.

Herpes simplex virus (HSV) encephalitis is the most common cause of sporadic fatal encephalitis worldwide, and central nervous system (CNS) involvement is observed in approximately one-third of neonatal HSV infections . In recent years, single-gene inborn errors of innate immunity have been shown to be associated with susceptibility to HSV encephalitis . Temporal lobe abnormalities revealed by magnetic resonance imaging-the most sensitive imaging method for HSV encephalitis-are considered strong evidence for the disease. Read More

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http://dx.doi.org/10.1007/978-981-10-7230-7_5DOI Listing
November 2018
1 Read

B/L Basal Ganglia Lesions in a Child Leading to a Diagnosis of Glucose-6-Phosphate Dehydrogenase Deficiency.

Ann Neurosci 2018 Apr 21;25(1):50-52. Epub 2017 Nov 21.

Department of Radiodiagnosis and Imaging, PGIMER, Chandigarh, India.

Bilateral basal ganglia lesions are a common non-specific finding seen in many diseases. One of the differential diagnoses for it, in a child, is kernicterus occurring due to hyperbilirubinemia. Glucose-6-phosphate dehydrogenase (G6PD) deficiency is a common cause of severe hyperbilirubinemia. Read More

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https://www.karger.com/Article/FullText/481907
Publisher Site
http://dx.doi.org/10.1159/000481907DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5981589PMC
April 2018
13 Reads

Fatal case of amoebic encephalitis masquerading as herpes.

Oxf Med Case Reports 2018 May 3;2018(5):omy010. Epub 2018 May 3.

Department of Medicine, National Center for Rheumatic Diseases, Medicine, Pashupati Sadak, Kathmandu-9, Kathmandu, Nepal.

Primary amoebic meningoencephalitis (PAM) is a rare, fulminating, hemorrhagic infection of the brain caused by , a thermophilic, free-living amoeba. A 74-year male presented with sudden severe global headache and fever with features of anomic aphasia. Magnetic resonance imaging (MRI) suggested herpes encephalitis and acyclovir (IV) was started but the patient developed altered sensorium, agitation and progressive weakness of lower limbs with gradual truncal weakness. Read More

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http://dx.doi.org/10.1093/omcr/omy010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5934662PMC
May 2018
9 Reads

Neurosyphilis: mighty imitator forays with benign presentation and unique neuroimaging findings.

Sex Health 2018 Apr 30. Epub 2018 Apr 30.

Common causes of temporal lobe hyper intensities are central nervous system infections like herpes simplex encephalitis, Lyme disease, limbic encephalitis and vascular pathology like Cerebral Autosomal Dominant Arteriopathy with Subcortical infarcts and Leukoencephalopathy. Personal assessment, laboratory data analysis and neuroimaging for the patient who was admitted to a central Pennsylvania tertiary care referral centre were conducted. A 52-year-old male presented with a 1-year history of diffuse dysesthesia in upper and lower extremities with associated intermittent headaches and neck stiffness. Read More

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http://dx.doi.org/10.1071/SH17088DOI Listing
April 2018
5 Reads

Severe aseptic temporal lobe encephalitis on fingolimod.

Mult Scler Relat Disord 2018 Jul 16;23:4-6. Epub 2018 Apr 16.

University of Toronto, Division of Neurology, Canada; St. Michael's Hospital, Toronto, Ontario, Canada.

We report the case of an MS patient with aseptic temporal lobe encephalitis while on treatment with fingolimod. This 49-year-old woman developed headache and decreasing level of consciousness after 3.5 years of fingolimod therapy. Read More

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http://dx.doi.org/10.1016/j.msard.2018.04.008DOI Listing
July 2018
1 Read

Acute encephalitis - diagnosis and management.

Clin Med (Lond) 2018 03;18(2):155-159

The Walton Centre NHS Foundation Trust, Liverpool, UK.

Encephalitis, inflammation of the brain, is most commonly caused by a viral infection (especially herpes simplex virus [HSV] type 1 in the UK) although autoimmune causes, such as N-methyl D-aspartate receptor (NMDAR) antibody encephalitis, are increasingly recognised. Most patients present with a change in consciousness level and may have fever, seizures, movement disorder or focal neurological deficits. Diagnosis hinges crucially on lumbar puncture and cerebrospinal fluid (CSF) examination, but imaging and electroencephalography (EEG) may also be helpful. Read More

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http://dx.doi.org/10.7861/clinmedicine.18-2-155DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6303463PMC
March 2018
3 Reads

Herpes Simplex Virus Encephalitis: Atypical Presentation as a Right Middle Cerebral Artery Stroke.

Cureus 2018 Jan 15;10(1):e2067. Epub 2018 Jan 15.

Attending Physician, Charleston Area Medical Center / West Virginia University.

Herpes simplex virus encephalitis (HSVE) is a medical emergency associated with high mortality and morbidity. Definitive diagnosis is established by history, clinical examination, neuroimaging studies, supportive electroencephalogram (EEG) findings, and cerebrospinal fluid (CSF) analysis. We report a case of HSVE presenting as a stroke mimic in a 76-year-old female with a history of atrial fibrillation on warfarin. Read More

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http://dx.doi.org/10.7759/cureus.2067DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5858849PMC
January 2018
1 Read

[An Autopsy Case of Meningoencephalitis and Cerebral Infarction that Developed with Ramsay Hunt Syndrome and Disseminated Herpes Zoster].

Brain Nerve 2018 Mar;70(3):253-258

Department of Neurology, Faculty of Medicine, University of Yamanashi.

We report here the clinical presentation and subsequent autopsy of a 90-year-old man who developed small papules with pain and swelling in his right ear. On admission, he exhibited right facial nerve paralysis, neck stiffness and Kernig's sign. The cell count was elevated and the varicella-zoster virus-PCR was positive in the CSF. Read More

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http://dx.doi.org/10.11477/mf.1416200990DOI Listing
March 2018
2 Reads

Autoimmune GFAP astrocytopathy after viral encephalitis: A case report.

Mult Scler Relat Disord 2018 Apr 19;21:84-87. Epub 2018 Feb 19.

Department of Neurology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China; Neurosciences Center, Chinese Academy of Medical Sciences, Beijing, China.

Autoimmune glial fibrillary acidic protein (GFAP) astrocytopathy is a novel autoimmune disease. This is the first report of a case of autoimmune GFAP astrocytopathy after herpes simplex viral encephalitis (HSVE). A 35-year-old female patient presented with a combination of headache, fever, seizure and psychiatric/behavioral abnormalities. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S22110348183007
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http://dx.doi.org/10.1016/j.msard.2018.02.020DOI Listing
April 2018
7 Reads

A Rare Case of Concurrent Herpes Simplex Encephalitis and Glioblastoma Multiforme.

Asian J Neurosurg 2018 Jan-Mar;13(1):78-82

Department of Neuropathology, Hull Royal Infirmary, Hull, United Kingdom.

Herpes encephalitis superimposed on an intracranial malignancy has previously been described mainly in the context of malignancy imitating infection or in the postoperative setting after neurosurgical intervention. We report a rare case of presentation of concurrent herpes encephalitis and glioblastoma. A 63-year-old man presented with status epilepticus and subsequent magnetic resonance imaging (MRI) brain showed a right temporal enhancing lesion with mass effect. Read More

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http://dx.doi.org/10.4103/1793-5482.181141DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5820902PMC
March 2018
38 Reads

Herpes simplex virus (HSV) encephalitis in a young man: an unusual course.

BMJ Case Rep 2018 Feb 24;2018. Epub 2018 Feb 24.

Department of Medicine, Division of Neurology, Ng Teng Fong General Hospital, Singapore.

We present a case of cerebral venous sinus thrombosis (CVST) as a rare complication of herpes simplex virus (HSV) encephalitis. A young man with no pertinent medical history was diagnosed with HSV encephalitis. After initial treatment, he showed improvement in symptomatology until day 6 when he acutely developed new neurological deficits. Read More

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http://dx.doi.org/10.1136/bcr-2017-222499DOI Listing
February 2018
10 Reads

Aetiology of acute encephalitis syndrome in Uttar Pradesh, India from 2014 to 2016.

J Vector Borne Dis 2017 Oct-Dec;54(4):311-316

Department of Microbiology, King George's Medical University, Lucknow, India.

Background & Objectives: It is imperative to know the aetiology of acute encephalitis syndrome (AES) for patient management and policy making. The present study was carried out to determine the prevalence of common aetiological agents of AES in Uttar Pradesh (UP) state of India.

Methods: Serum and/or CSF samples were collected from AES patients admitted at Gandhi Memorial and Associated Hospital, King George's Medical University, Lucknow, a tertiary care centre, UP during 2014-16. Read More

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http://dx.doi.org/10.4103/0972-9062.225835DOI Listing
November 2018
4 Reads

[Acute polyradiculoneuropathy associated with human Herpes Virus 7 in an immunocompetent patient. Case report].

Rev Med Chil 2017 Sep;145(9):1218-1221

Departamento de Medicina Interna Clínica Alemana de Santiago, Universidad del Desarrollo, Santiago, Chile.

Human herpes virus 7 (HHV-7) is a cause of encephalitis, meningitis and myeloradiculoneuropathy in adults who are immunocompetent or with immunosuppression. The involvement of the peripheral nervous system is always associated with myelitis. We report a case of acute polyradiculoneuropathy due to HHV-7, without involvement of central nervous system, in an immunocompetent patient. Read More

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http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S
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http://dx.doi.org/10.4067/s0034-98872017000901218DOI Listing
September 2017
6 Reads

Case of Primary Central Nervous System Lymphoma Arising at Site of Remote Herpes Encephalitis.

World Neurosurg 2018 May 31;113:217-222. Epub 2018 Jan 31.

Department of Radiology, Vancouver General Hospital (VGH), Jim Pattison Pavilion, Vancouver, British Columbia, Canada.

Background: Primary central nervous system lymphoma (PCNSL) is a rare malignancy that usually arises in the context of severe immunosuppression but has incompletely understood etiology, limiting effective treatments.

Case Description: We present the case of an 81-year-old immunocompetent man who developed a PCNSL in the right temporal lobe, at the site of a remote episode of herpes simplex virus (HSV) encephalitis 8 years prior. There are numerous viruses with known oncogenic associations; however, to our knowledge, this is the first reported case of PCNSL with an antecedent HSV infection. Read More

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http://dx.doi.org/10.1016/j.wneu.2018.01.143DOI Listing
May 2018
6 Reads

Pitfalls in clinical diagnosis of anti-NMDA receptor encephalitis.

J Neurol 2018 Mar 22;265(3):586-596. Epub 2018 Jan 22.

Department of Neurology, Kitasato University School of Medicine, 1-15-1 Kitasato, Minami-ku, Sagamihara, Kanagawa, 252-0374, Japan.

Objectives: To report pitfalls in the clinical diagnosis of anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis.

Methods: We retrospectively reviewed the clinical information of 221 patients with clinically suspected autoimmune neurological disorders who underwent testing for autoantibodies against neuronal cell-surface antigens between January 1, 2007 and September 10, 2017. Forty-one patients met the diagnostic criteria for probable anti-NMDAR encephalitis (probable criteria), but one was excluded because neither serum nor CSF was examined at the active stage. Read More

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http://link.springer.com/10.1007/s00415-018-8749-3
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http://dx.doi.org/10.1007/s00415-018-8749-3DOI Listing
March 2018
7 Reads

HSV encephalitis: is the insight of the clinician still crucial for the outcome?

Folia Med Cracov 2017 ;57(4):97-105

M. Alexandrou 3B, Pefka, Thessaloniki 57010, Greece.

Herpes simplex virus (HSV) encephalitis is an acute infection of the Central Nervous System (CNS). During the last two decades its incidence has a ten-fold increase, while mortality rate exceeds 70%, if left undiagnosed and thus untreated. Clinical manifestations, imaging studies, cerebrospinal fluid (CSF) analysis and electroencephalogram (EEG) are the basis of diagnostic approach. Read More

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January 2017
4 Reads

Early rehabilitation results in a child who developed herpes simplex encephalitis.

North Clin Istanb 2017 23;4(3):273-274. Epub 2017 Oct 23.

Department of Physical Therapy and Rehabilitation, Inonu University Medicine Faculty, Malatya, Turkey.

In this case, a 4-year-old girl was admitted to the emergency service with the complaints of a sudden onset of fever, shortness of breath, jerking motions of the hands and feet and a sliding mouth. Her condition deteriorated, and she was kept under observation in the intensive care unit for 6 days. The Glasgow Coma Score of the patient was 1. Read More

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http://dx.doi.org/10.14744/nci.2017.24582DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5724925PMC
October 2017
8 Reads

How Does Imaging of Congenital Zika Compare with Imaging of Other TORCH Infections?

Radiology 2017 12;285(3):744-761

From the Department of Radiology, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Ave, Boston, MA 02215 (D.L.); Departments of Obstetrics and Gynecology (J.C.J.) and Radiology (M.C.), University Hospital Brugmann, Université Libre de Bruxelles, Brussels, Belgium; Department of Radiology, UZ Brussel, Vrije Universiteit Brussel, Brussels, Belgium (M.C.); and Department of Radiology, Boston Medical Center, Boston University, Boston, Mass (I.C.).

The acronym TORCH is used to refer to congenital infections, such as toxoplasmosis, other infections (such as syphillis, varicella-zoster, and parvovirus B19), cytomegalovirus, and herpes simplex virus. The classic findings in patients with TORCH infections include rash in the mother during pregnancy and ocular findings in the newborn. Zika virus has emerged as an important worldwide congenital infection. Read More

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http://dx.doi.org/10.1148/radiol.2017171238DOI Listing
December 2017
9 Reads
6.867 Impact Factor

Cerebral toxoplasmosis in an MS patient receiving Fingolimod.

Mult Scler Relat Disord 2017 Nov 12;18:106-108. Epub 2017 May 12.

Fundación Valle del Lili, Cali, Colombia; Universidad ICESI, Cali, Colombia. Electronic address:

Multiple Sclerosis (MS) is an autoimmune disease in which lymphocytes target putative myelin antigens in the CNS, causing inflammation and neurodegeneration. Fingolimod (FTY720) is an immunosuppressive drug used as a second line therapy for relapsing forms of MS due to its safety profile and good response to treatment. Despite its safety, there are still concerns about the possibility of Fingolimod being linked to the development of opportunistic infections like disseminated varicella zoster infections and herpes simplex encephalitis. Read More

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http://dx.doi.org/10.1016/j.msard.2017.05.004DOI Listing
November 2017
14 Reads

Review of Viral Encephalitis Cases Seen at a Tertiary Care Center in Turkey: Focus on Herpes Simplex Type 1.

Noro Psikiyatr Ars 2017 Sep 1;54(3):209-215. Epub 2016 Sep 1.

Clinic of Neurology, Bakırköy Prof. Dr. Mazhar Osman Psychiatric Training and Research Hospital, İstanbul, Turkey.

Introduction: The objective of this study was to determine the incidence of herpes simplex encephalitis (HSE), known as the most common, potentially mortal, and treatable cause of sporadic encephalitis, in a sample Turkish population.

Methods: The demographic, clinical, laboratory, imaging, electrophysiology, and polymerase chain reaction (PCR) DNA results of patients examined with a pre-diagnosis of encephalitis were retrospectively examined.

Results: A total of 68 patients were included in the study. Read More

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http://dx.doi.org/10.5152/npa.2016.12540DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5630098PMC
September 2017
10 Reads

Painful loss of vision after an episode of herpes simplex encephalitis.

Intern Med J 2017 10;47(10):1210-1211

Department of Infectious Diseases, Alfred Health and Monash University, Melbourne, Victoria, Australia.

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http://dx.doi.org/10.1111/imj.13562DOI Listing
October 2017
10 Reads

Fetal ventriculomegaly and herpes encephalitis following primary maternal herpes simplex infection.

Proc (Bayl Univ Med Cent) 2017 Oct;30(4):463-464

Department of Obstetrics and Gynecology, Baylor Scott & White Health and Texas A&M Health Science Center College of Medicine, Temple, Texas.

Uteroplacental transmission of a primary herpes simplex virus (HSV) infection in pregnancy has been reported; however, HSV ventriculomegaly of the neonate has not been well documented in utero. We present a case of a 19-year-old woman who developed a primary HSV outbreak at 17 weeks of gestation and was treated with acyclovir. A congenital malformation scan at 18 weeks of gestation demonstrated no fetal abnormalities; however, an ultrasound at 33 weeks showed a new finding of ventriculomegaly. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5595398PMC
October 2017
19 Reads

Postherpetic Anti-N-methyl-D-aspartate Receptor Encephalitis after Hemispherotomy in a Patient with Intractable Startle Epilepsy.

Neuropediatrics 2018 02 22;49(1):63-67. Epub 2017 Sep 22.

Department of Neurology, Faculty of Medicine, Hacettepe University, Ankara, Turkey.

Herpes simplex encephalitis (HSE) has been increasingly reported after neurosurgical procedures, mostly after tumor resections in patients with a prior history of HSE. Early detection and appropriate treatment are essential to prevent high mortality of the disease; however, there are diagnostic difficulties due to nonspecific prodromal symptoms. In addition, anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis has been reported after HSE as an immunological relapse. Read More

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http://www.thieme-connect.de/DOI/DOI?10.1055/s-0037-1606640
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http://dx.doi.org/10.1055/s-0037-1606640DOI Listing
February 2018
16 Reads

Syndromes of Rapidly Progressive Cognitive Decline-Our Experience.

J Neurosci Rural Pract 2017 Aug;8(Suppl 1):S66-S71

Department of Neurology, National Institute of Mental Health and Neurosciences, Bengaluru, Karnataka, India.

Background: Dementias are fairly slowly progressive degenerative diseases of brain for which treatment options are very less and carry a lot of burden on family and society. A small percentage of them are rapidly progressive and mostly carry a different course outcome. However, there are no definite criteria other than the time line for these patients. Read More

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http://www.ruralneuropractice.com/text.asp?2017/8/5/66/21359
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http://dx.doi.org/10.4103/jnrp.jnrp_100_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5602264PMC
August 2017
47 Reads

[Investigation of bacterial and viral etiology in community acquired central nervous system infections with molecular methods].

Mikrobiyol Bul 2017 Jul;51(3):277-285

Sabuncuoglu Serefeddin Training and Research Hospital, Department of Infectious Diseases and Clinical Microbiology, Amasya, Turkey.

In this multicenter prospective cohort study, it was aimed to evaluate the bacterial and viral etiology in community-acquired central nervous system infections by standart bacteriological culture and multiplex polymerase chain reaction (PCR) methods. Patients hospitalized with central nervous system infections between April 2012 and February 2014 were enrolled in the study. Demographic and clinical information of the patients were collected prospectively. Read More

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http://dx.doi.org/10.5578/mb.57358DOI Listing
July 2017
52 Reads

Emergency Neurologic Life Support: Meningitis and Encephalitis.

Neurocrit Care 2017 Sep;27(Suppl 1):124-133

Department of Internal Medicine, Division of Critical Care, Boone Hospital Center, BJC Health Care, Columbia, MO, USA.

Bacterial meningitis and viral encephalitis, particularly herpes simplex encephalitis, are severe neurological infections that, if not treated promptly and effectively, lead to poor neurological outcome or death. Because of the value of early recognition and treatment, meningitis and encephalitis was chosen as an Emergency Neurological Life Support protocol. This protocol provides a practical approach to recognition and urgent treatment of bacterial meningitis and encephalitis. Read More

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http://dx.doi.org/10.1007/s12028-017-0455-yDOI Listing
September 2017
18 Reads

Concomitant neurosyphilis and herpes simplex encephalitis in an immunocompetent patient: a case report.

Neurol Sci 2018 01 15;39(1):185-187. Epub 2017 Sep 15.

Neurology Service, Hospital Universitario "Dr. José E. González" and Medical School, Universidad Autónoma de Nuevo León, Madero y Gonzalitos S/N, 64460, Monterrey, NL, Mexico.

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http://dx.doi.org/10.1007/s10072-017-3115-2DOI Listing
January 2018
20 Reads

Slowly progressing varicella zoster brainstem encephalitis complicating Ramsay Hunt syndrome in an immunocompetent patient: case report and review of the literature.

J Neurovirol 2017 12 13;23(6):922-928. Epub 2017 Sep 13.

Department of Biomedical Sciences for Health, IRCCS Policlinico San Donato, University of Milan, Piazza E. Malan 1, San Donato Mil.se, 20097, Milan, Italy.

A 56-year-old immunocompetent male developed brainstem encephalitis complicating Ramsay Hunt syndrome. The disease had a slowly progressing course of months after the triggering infection, much longer than previously reported. Furthermore, magnetic resonance imaging, physical-chemical, and cell count analyses on cerebrospinal fluid were normal, whereas polymerase chain reaction for varicella zoster virus DNA was positive. Read More

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http://dx.doi.org/10.1007/s13365-017-0575-3DOI Listing
December 2017
21 Reads

HSV-1 Encephalitis: High Index of Clinical Suspicion, Prompt Diagnosis, and Early Therapeutic Intervention Are the Triptych of Success-Report of Two Cases and Comprehensive Review of the Literature.

Case Rep Med 2017 16;2017:5320839. Epub 2017 Aug 16.

Department of Internal Medicine, General Hospital of Veria, Veria, Greece.

Herpes Simplex Virus (HSV) encephalitis is an acute infectious disease of the Central Nervous System (CNS), usually affecting the limbic structures, the median temporal cortex, and the orbitofrontal regions. Its annual incidence has significantly increased over the last 20 years and the mortality rate is 7%, if early diagnosed and treated, and 70%, if left untreated, while it is associated with high rates of morbidity. It should be noted that even when Cerebrospinal fluid (CSF) analysis seems normal, imaging studies are not specific and HSV Polymerase Chain Reaction (PCR) test is negative; the clinician should be more aggressive, if clinical presentation is indicative for HSV encephalitis, by administrating acyclovir early after patient's admission. Read More

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http://dx.doi.org/10.1155/2017/5320839DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5576427PMC
August 2017
11 Reads

HSV-2 encephalitis presenting as multifocal ischemic stroke.

Neurol Sci 2017 12 31;38(12):2229-2230. Epub 2017 Aug 31.

Department of Neurology, University of Miami Miller School of Medicine/Jackson Health System, Miami, FL, 33136, USA.

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http://dx.doi.org/10.1007/s10072-017-3100-9DOI Listing
December 2017
4 Reads