84 results match your criteria Imaging in Ganglioneuroma and Ganglioneuroblastoma


Clinical and Pathological Evidence of Anti-GD2 Immunotherapy Induced Differentiation in Relapsed/Refractory High-Risk Neuroblastoma.

Cancers (Basel) 2021 Mar 12;13(6). Epub 2021 Mar 12.

Pathology Department, Pediatric Cancer Center Barcelona, Hospital Sant Joan de Déu, 08950 Barcelona, Spain.

Background: Neuroblastic tumors (NBTs) originate from a block in the process of differentiation. Histologically, NBTs are classified in neuroblastoma (NB), ganglioneuroblastoma (GNB), and ganglioneuroma (GN). Current therapy for high-risk (HR) NB includes chemotherapy, surgery, radiotherapy, and anti-GD2 monoclonal antibodies (mAbs). Read More

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Diagnostic values of Ga-labelled DOTANOC PET/CT imaging in pediatric patients presenting with paraneoplastic opsoclonus myoclonus ataxia syndrome.

Eur Radiol 2021 Jan 6. Epub 2021 Jan 6.

Department of Pediatric Neurology, Post Graduate Institute of Medical Education and Research, Chandigarh, India.

Objectives: Opsoclonus myoclonus ataxia (OMA) syndrome, also known as "Kinsbourne syndrome" or "dancing eye syndrome," is a rare, paraneoplastic entity which may be associated with pediatric neuroblastic tumors and carry a grave prognosis. We aimed to evaluate the role of Ga DOTANOC PET/CT for detecting neuroblastic tumors in patients with OMA syndrome.

Methods: We retrospectively evaluated the Ga-DOTANOC PET/CT data of pediatric patients presenting with OMA syndrome from March 2012 to November 2018. Read More

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January 2021

Feasibility and possible value of quantitative semi-automated diffusion weighted imaging volumetry of neuroblastic tumors.

Cancer Imaging 2020 Dec 17;20(1):89. Epub 2020 Dec 17.

Department of Diagnostic and Interventional Radiology, University Hospital Tuebingen, Hoppe-Seyler-Straße 3, 72076, Tuebingen, Germany.

Background: To assess the feasibility and possible value of semi-automated diffusion weighted imaging (DWI) volumetry of whole neuroblastic tumors with apparent diffusion coefficient (ADC) map evaluation after neoadjuvant chemotherapy.

Methods: Pediatric patients who underwent surgical resection of neuroblastic tumors at our institution from 2013 to 2019 and who received a preoperative MRI scan with DWI after chemotherapy were included. Tumor volume was assessed with a semi-automated approach in DWI using a dedicated software prototype. Read More

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December 2020

Brain paraneoplastic syndromes in a patient with mediastinal ganglioneuroma.

Radiol Case Rep 2020 Nov 2;15(11):2059-2062. Epub 2020 Sep 2.

Department of Pediatric Radiology, Hospital Universitari Vall d'Hebron, Passeig de la Vall d'Hebron 119-129 08035, Barcelona, Spain.

Paraneoplastic neurologic syndromes are a rare and heterogeneous group of immune-mediated syndromes caused by underlying solid and nonsolid tumors. We present a case of 8-year-old female with long history of mild headaches and central instability who presented multiple poorly defined signal abnormalities at the subcortical white matter of both cerebral hemispheres and cerebellar atrophy on brain magnetic resonance imaging. Further studies revealed a posterior mediastinum ganglioneuroma derived from a mature ganglioneuroblastoma that was treated with surgery. Read More

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November 2020

Retrospective accuracy analysis of MRI based lesion size measurement in neuroblastic tumors: which sequence should we choose?

BMC Med Imaging 2020 09 10;20(1):105. Epub 2020 Sep 10.

Department of Diagnostic and Interventional Radiology, University Hospital Tuebingen, Hoppe-Seyler-Straße 3, 72076, Tuebingen, Germany.

Background: MR imaging of neuroblastic tumors is widely used for assessing the effect of chemotherapy on tumor size. However, there are some concerns that MRI might falsely estimate lesion diameters due to calcification and fibrosis. Therefore, the aim of our study was to compare neuroblastic tumor size based on MRI measurements to histopathology measurements of the resected specimens as standard of reference. Read More

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September 2020

Retroperitoneal Ganglioneuroma in a Patient Presenting With Vague Abdominal Pain.

Cureus 2020 Jul 11;12(7):e9133. Epub 2020 Jul 11.

Emergency Medicine, Usman Memorial Hospital, Karachi, PAK.

Ganglioneuroblastoma, neuroblastoma, and ganglioneuroma (GN) are the tumors that arise from the neural crest cells. Of these, GN has the most benign origin without metastatic potential. The most common sites of their origin are the posterior mediastinum and retroperitoneum. Read More

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Suprasellar central nervous system ganglioneuroblastoma: a case in a 9-year-old child and review of the literature.

Childs Nerv Syst 2020 11 3;36(11):2845-2849. Epub 2020 Apr 3.

Department of Neurosurgery, Pennsylvania State University College of Medicine, Hershey, PA, 17033, USA.

Purpose: Intracranial ganglioneuroblastomas are incredibly rare neuroectodermal tumors with only 8 described cases total, 5 of those having imaging findings METHODS: Here we present a 9-year-old female patient with 4 months progressive headaches, personality changes, and vomiting. We also present a review of the current literature of intracranial ganglioneuroblastomas.

Results: Imaging demonstrated a partially calcified suprasellar mass measuring 4. Read More

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November 2020

Importance of Magnetic Resonance Imaging With Diffusion-weighted Imaging in Guiding Biopsy of Nodular Ganglioneuroblastoma: A Case Report.

J Pediatr Hematol Oncol 2021 01;43(1):e130-e135

Haematology and Oncology Department, Great Ormond Street Hospital.

Background: Nodular ganglioneuroblastoma is a rare peripheral neuroblastic tumor of variable prognosis. Accurate diagnosis, staging, and risk categorization can be particularly challenging in patients with nodular ganglioneuroblastoma due to the inherent heterogeneity of these lesions.

Case Presentation: We illustrate the use of diffusion-weighted magnetic resonance imaging to identify tumor nodules and guide tumor biopsy in an almost 5-year-old boy with a large abdominal tumor. Read More

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January 2021

Resection of a thoracoabdominal ganglioneuroma via a retroperitoneal minimally invasive approach.

J Pediatr Surg Case Rep 2019 Jan 25;40:47-49. Epub 2018 Oct 25.

University of California - Davis, Division of Pediatric General, Thoracic and Fetal Surgery, USA.

A 10-year-old girl presented to her pediatrician with a history of cough and fever. A chest radiograph revealed a paraspinal mass. On cross-sectional imaging, the mass traversed the diaphragm, extending from T9 to L1 spinal levels with involvement of the T10-12 neural foramen. Read More

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January 2019

Adrenal masses in children: Imaging, surgical treatment and outcome.

Asian J Surg 2020 Jan 6;43(1):207-212. Epub 2019 Apr 6.

Department of Pediatric Surgery, Cerrahpasa Medical Faculty, Istanbul University-Cerrahpasa, Turkey.

Background/objective: This study aims to evaluate the current surgical approach to adrenal masses in the pediatric age group.

Methods: We retrospectively analyzed cases that underwent surgery for adrenal masses between 2007 and 2017. Patients were assessed regarding age, sex, primary diagnosis, image defined risk factors (IDRF), surgical treatment method, complications, duration of hospital stay, and follow-up. Read More

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January 2020

Multidisciplinary surgical strategy for dumbbell neuroblastoma: A single-center experience of 32 cases.

Pediatr Blood Cancer 2019 08 4;66 Suppl 3:e27670. Epub 2019 Mar 4.

Department of Pediatric Surgery and Urology, Hôpital Necker-Enfants Malades, Assistance Publique-Hôpitaux de Paris, Paris, France.

Introduction: Prognosis of dumbbell neuroblastoma (NBL) is mainly determined by the sequelae induced by the tumor itself and the neurosurgical approach. However, after primary chemotherapy, surgical management of the residual tumor, especially the spinal canal component, remains controversial.

Methods: We conducted a single-center retrospective cohort study over the last 15 years (2002-2017) including patients treated for NBL with spinal canal extension focusing on timing and type of surgery, complications, and functional and oncological follow-up. Read More

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Quantitative DWI predicts event-free survival in children with neuroblastic tumours: preliminary findings from a retrospective cohort study.

Eur Radiol Exp 2019 Jan 30;3(1). Epub 2019 Jan 30.

Department of Diagnostic and Interventional Radiology, University Hospital Ulm, Albert-Schweitzer-Allee 23, 89081, Ulm, Germany.

Background: Quantitative diffusion-weighted imaging (DWI) probes into tissue microstructure in solid tumours. In this retrospective ethically approved study, we investigated DWI as a potential non-invasive predictor of tumour dignity and prognosis in paediatric patients with neuroblastic tumours.

Methods: Nineteen consecutive patients with neuroblastoma (NB, n = 15), ganglioneuroblastoma (GNB, n = 1) and ganglioneuroma (GN, n = 3) underwent 3-T magnetic resonance imaging at first diagnosis and after 3-month follow-up, following a protocol including DWI (b = 50 and 800 s/mm) in addition to standard sequences. Read More

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January 2019

Statistical Framework in Support of a Revised Children's Oncology Group Neuroblastoma Risk Classification System.

JCO Clin Cancer Inform 2018 12;2:1-15

Arlene Naranjo, University of Florida, Gainesville, FL; Meredith S. Irwin, Hospital for Sick Children, Toronto, ON, Canada; Michael D. Hogarty, University of Pennsylvania, Philadelphia, PA; Susan L. Cohn, The University of Chicago, Chicago, IL; Julie R. Park, University of Washington, Seattle, WA; and Wendy B. London, Dana-Farber/Boston Children's Cancer and Blood Disorders Center and Harvard Medical School, Boston, MA.

Purpose: The International Neuroblastoma Risk Group (INRG) Staging System (INRGSS) was developed through international consensus to provide a presurgical staging system that uses clinical and imaging data at diagnosis. A revised Children's Oncology Group (COG) neuroblastoma (NB) risk classification system is needed to incorporate the INRGSS and within the context of modern therapy. Herein, we provide statistical support for the clinical validity of a revised COG risk classification system. Read More

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December 2018

High Oct4 expression: implications in the pathogenesis of neuroblastic tumours.

BMC Cancer 2019 Jan 3;19(1). Epub 2019 Jan 3.

Pathology Department, Medical School, University of Valencia-INCLIVA, Av. Blasco Ibáñez, 15, 46010, Valencia, Spain.

Background: Neuroblastic tumours (NBTs) are paediatric solid tumours derived from embryonic neural crest cells which harbour their own cancer stem cells (CSC). There is evidence indicating that CSC may be responsible for tumour progression, chemotherapy resistance and recurrence in NBTs. Oct4 is a transcription factor which plays a key role in mammal embryonic development and stem cell fate regulation. Read More

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January 2019

Peripheral neuroblastic tumor of the kidney: case report and review of literature.

Tumori 2018 Dec 19;104(6):NP34-NP37. Epub 2018 Jul 19.

1 Pediatric Oncology Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.

Introduction: Peripheral neuroblastic tumors (PNTs) account for 8%-10% of all pediatric tumors. Adrenal glands and sympathetic ganglia are the commonest site of tumor growth. In the clinicopathologic spectrum of PNTs, neuroblastoma and ganglioneuroma are the most primitive and the most mature tumor form, while ganglioneuroblastoma represents an intermediate state of maturation. Read More

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December 2018

Multifactorial analysis of opsoclonus-myoclonus syndrome etiology ("Tumor" vs. "No tumor") in a cohort of 356 US children.

Pediatr Blood Cancer 2018 08 4;65(8):e27097. Epub 2018 May 4.

National Pediatric Myoclonus Center, National Pediatric Neuroinflammation Organization, Inc., Orlando, Florida, USA.

Background: Pediatric opsoclonus-myoclonus syndrome (OMS) presents a paradox of etiopathogenesis: A neuroblastic tumor (NB) is found in only one half of the cases, the others are ascribed to infections or designated as idiopathic.

Method: From an IRB-approved observational study of 356 US children with OMS, secondary analysis of "etiology" and related factors was performed on a well-characterized cohort. The "Tumor" (n = 173) and "No Tumor" groups (n = 183), as defined radiologically, were compared according to multiple factors considered potentially differentiating. Read More

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Usefulness of fluorodeoxyglucose positron emission tomography/computed tomography for detection of a neuroblastic nodule in a ganglioneuroblastoma: a case report.

J Med Case Rep 2018 May 3;12(1):119. Epub 2018 May 3.

Department of Pediatric Oncology, Fukushima Medical University Hospital, 1 Hikarigaoka, Fukushima City, Fukushima, 960-1295, Japan.

Background: Ganglioneuroblastoma, nodular is defined as a composite tumor of biologically distinct clones. The peripheral neuroblastic tumors in this category are characterized by the presence of grossly visible neuroblastoma nodules coexisting with ganglioneuroblastoma, intermixed, or with ganglioneuroma. Making a correct diagnosis of ganglioneuroblastoma, nodular is often difficult by biopsy or partial tumor resection, because the neuroblastic nodule could be hidden and not sampled for pathological examination. Read More

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Neuroblastic tumors in young adults as a sequela of malignant neuroblastoma: report of two cases.

Abdom Radiol (NY) 2018 07;43(7):1531-1534

Department of Diagnostic Radiology, Tokyo Medical and Dental University, 1-5-45, Yushima, Bunkyo, Tokyo, 113-8519, Japan.

Neuroblastoma, ganglioneuroblastoma, and ganglioneuroma share the same histological spectrum which originates from neural crest cells. We present herein two young adult patients with neuroblastic tumors with lymph node metastases. Both the patients were diagnosed incidentally as having retroperitoneal masses, which showed little or no immature cells despite coexistence of lymph node involvement. Read More

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Characteristics and management of ganglioneuroma and ganglioneuroblastoma-intermixed in children and adolescents.

Pediatr Blood Cancer 2018 05 25;65(5):e26964. Epub 2018 Jan 25.

Division of Haematology & Oncology, Department of Pediatrics, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada.

Background: Ganglioneuromas (GNs) usually demonstrate favorable histological and clinical features. Surgery is often performed due to clinical symptoms and/or theoretical concerns that GN may transform into neuroblastoma (NB); however, several studies have identified significant GN-surgical morbidities.

Objectives: We compared the natural history, biological and clinical features of GN and ganglioneuroblastoma-intermixed (GNB-I) managed by surgery or observation to inform management and surveillance. Read More

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Diagnostic Value of Diffusion-Weighted MRI for Tumor Characterization, Differentiation and Monitoring in Pediatric Patients with Neuroblastic Tumors.

Rofo 2017 Jul 16;189(7):640-650. Epub 2017 May 16.

Department of Diagnostic and Interventional Radiology, University Hospital Ulm, Germany.

 We explored the diagnostic value of diffusion-weighted MRI (DWI) for tumor characterization, differentiation and therapy monitoring in pediatric patients with extracranial neuroblastic tumors.  All 29 patients (14 girls, median age: 3 years) with neuroblastoma (NB, n = 19), ganglioneuroblastoma (GNB, n = 4) and ganglioneuroma (GN, n = 6) who had had at least one in-house DWI examination since 2005 were identified and retrospectively analyzed. Two independent blinded readers measured ADC values (unit: 10-3 mm/s) and signal intensity ratios (SIRs) of the primary tumor and, if applicable, of the tumor after chemotherapy, metastases and tumor relapse. Read More

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Role of diffusion-weighted imaging in distinguishing thoracoabdominal neuroblastic tumours of various histological types and differentiation grades.

J Med Imaging Radiat Oncol 2017 Dec 16;61(6):718-724. Epub 2017 May 16.

Department of Pathology, Beijing Children's Hospital, Capital Medical University, Beijing, China.

Introduction: Diffusion-weighted MR imaging (DWI) has demonstrated a great potential to help distinguish benign from malignant tumours in paediatric body. Our purpose is to evaluate whether DWI allow discrimination of thoracoabdominal neuroblastic tumours of various histological types and differentiation grades.

Methods: We retrospectively analysed DWI scans of the thoracoabdominal neuroblastic tumours in 25 children (11 girls, 14 boys). Read More

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December 2017

Clinical characteristics of adrenal tumors in children: a retrospective review of a 15-year single-center experience.

Int Urol Nephrol 2017 Mar 17;49(3):381-385. Epub 2016 Dec 17.

Department of Pediatric Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.

Objective: Adrenal tumors are rare in children. The aim of this study is to review and analyze clinical data on the diagnosis and management of adrenal tumors in children.

Methods: Between 2001 and 2015, 48 pediatric patients (<14 years old) admitted to our institute with adrenal tumors were reviewed. Read More

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Diffusion weighted imaging in differentiating malignant and benign neuroblastic tumors.

Jpn J Radiol 2016 Sep 14;34(9):620-4. Epub 2016 Jul 14.

Department of Radiology, Pediatric Radiology Section, Erciyes University School of Medicine, Melikgazi, Kayseri, Turkey.

Purpose: Our aim was to assess diffusion weighted imaging (DWI) of neuroblastic tumors and whether apparent diffusion coefficient (ADC) value may have a role in discrimination among neuroblastoma, ganglioneuroblastoma and ganglioneuroma.

Material And Methods: The DWIs (b = 0-800 s/mm(2)) of 24 children (13 girls, 11 boys) who were diagnosed neuroblastic tumors on histopathological examination (neuroblastoma = 15, ganglioneuroblastoma = 5, ganglioneuroma = 4) were evaluated retrospectively. The ADC maps were performed by drawing freehand ROI on PACS (Sectra Workstation IDS7, Linköping, Sweden). Read More

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September 2016

Imaging of Thoracic Neurogenic Tumors.

AJR Am J Roentgenol 2016 Sep 24;207(3):552-61. Epub 2016 Jun 24.

6 Department of Radiology and Radiological Sciences, Uniformed Services University of the Health Sciences, Bethesda, MD.

Objective: Thoracic neurogenic neoplasms may be a diagnostic challenge both clinically and radiologically, ranging from benign, incidentally discovered tumors to aggressive, symptomatic malignancies. These tumors may originate from any nervous structure within the chest and are derived from cells of the nerve sheath, autonomic ganglia, or paraganglia. The nervous anatomy of the thorax is complex, and neurogenic tumors may be found in any mediastinal compartment or in the chest wall. Read More

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September 2016

Lumbar Spinal Immature Ganglioneuroma with Conus Medullaris Invasion: Case Report.

Pediatr Neurosurg 2015 14;50(6):330-5. Epub 2015 Oct 14.

Ganglioneuroma (GN) is a benign rare tumor that originates from neural crest cells. It shares a common histogenic family with ganglioneuroblastoma and neuroblastoma and represents the most benign and differentiated form of the group. The most common locations of the GNs are the mediastinum and retroperitoneum. Read More

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September 2016

Long-term follow-up results of the observation program for neuroblastoma detected at 6-month mass screening.

J Pediatr 2014 Oct 3;165(4):855-7.e1. Epub 2014 Aug 3.

Department of Hematology/Oncology, Saitama Children's Medical Center, Saitama, Japan.

We conducted an observation program of neuroblastoma in infants, detected by mass screening at 6 months of age; we followed up with them for 15 years. No recurrence was observed after disappearance of tumors, and persistent tumors showed no malignant transformation or metastasis. Histology of the resected tumors showed age-related differentiation. Read More

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October 2014

Ganglioneuroblastoma of filum terminale: case report.

J Neurosurg Spine 2014 Aug 30;21(2):270-4. Epub 2014 May 30.

Departments of 1 Orthopedic Surgery and.

Object: Neuroblastic tumors can be classified as neuroblastoma, ganglioneuroblastoma (GNB), or ganglioneuroma. Ganglioneuroblastomas consist of small, round, immature neuroblast cells and matured ganglion cells. They are most commonly found in the mediastinum and retroperitoneum; intraspinal GNBs are extremely rare. Read More

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High ¹²³I-MIBG uptake in neuroblastic tumours indicates unfavourable histopathology.

Eur J Nucl Med Mol Imaging 2013 Oct 16;40(11):1701-10. Epub 2013 Jul 16.

Department of Nuclear Medicine, Ludwig-Maximilians-University of Munich, Marchioninistrasse 15, 81377, Munich, Germany,

Purpose: Scintigraphy using (123)I-metaiodobenzylguanidine ((123)I-MIBG) is widely used for the detection of neuroblastic tumours. The aim of this study was to identify a possible correlation between the uptake intensity on (123)I-MIBG SPECT and histopathology of neuroblastic tumours.

Methods: (123)I-MIBG SPECT examinations were performed in 55 paediatric patients with neuroblastic tumour and compared to histopathology after surgical resection or biopsy at a mean of 2 weeks after SPECT. Read More

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October 2013

The late recurrence of ganglioneuroma 21 years after initial presentation with neuroblastoma.

Pediatr Hematol Oncol 2012 Oct 11;29(7):647-51. Epub 2012 Sep 11.

Department of Neurosurgery and Neuro-Oncology, National Cancer Center Hospital, Tokyo, Japan.

A 3-year-old boy presented with tumors in the adrenal gland and the right orbit, and was diagnosed with neuroblastoma. After chemotherapy, the tumors were resected and the pathological diagnoses of ganglioneuroblastoma in the adrenal gland and ganglioneuroma in the orbit were made. The tumor relapsed at the intracranial dura mater 21 years after the initial diagnosis, and was diagnosed as ganglioneuroma from a biopsied sample. Read More

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October 2012

Laparoscopic adrenalectomy in children.

J Pediatr Urol 2012 Aug 29;8(4):379-85. Epub 2011 Sep 29.

Division of Urology, Hospital das Clínicas, University of São Paulo Medical School, Rua Dr. Enéas de Carvalho Aguiar, 455 - 7 andar, São Paulo, Brazil.

Purpose: Reporting on the laparoscopic technique for adrenal disease in children and adolescents has been limited. We review here our experience with laparoscopic adrenal surgery in children.

Patients And Methods: 19 laparoscopic unilateral adrenalectomies were performed in 10 girls and 7 boys (mean age 3. Read More

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