792 results match your criteria Imaging in Ganglioglioma

Bilateral oligodendroglial hamartomas: A rare cause of drug-resistant epilepsy in a pediatric patient.

J Clin Imaging Sci 2022 5;12:24. Epub 2022 May 5.

Department of Imaging Sciences, University of Rochester Medical Center, Rochester, New York, United States.

Intractable or drug-resistant seizures in pediatric patients are often secondary to cortical malformations, hamartomas, or mass lesions. Various subtypes of intracerebral hamartomas, associated with seizure disorders, have been described. In this report, we describe a subtype of intracerebral hamartoma associated with intractable epilepsy in a 10-year-old patient. Read More

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Infratentorial ganglioglioma mimicking a cerebellar metastasis.

Int J Neurosci 2022 Jun 2:1-5. Epub 2022 Jun 2.

Department of Neurosurgery, University Medical Center Göttingen, Göttingen, Germany.

We report a case of an infratentorial ganglioglioma in a 56-year-old male, who underwent magnetic resonance imaging (MRI) during the diagnostic workup for a suspected lung cancer. The MRI scan revealed a space-occupying lesion of the left lobulus semilunaris superior cerebelli, which was assumed being a metastasis. The asymptomatic lesion was resected to establish the diagnosis. Read More

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Multifocal Desmoplastic Infantile Ganglioglioma/Astrocytoma (DIA/DIG): An Institutional Series Report and a Clinical Summary of This Rare Tumor.

Front Oncol 2021 9;11:608129. Epub 2022 May 9.

School of Computer Science and Engineering, University of Electronic Science and Technology of China, Chengdu, China.

Aim: Multifocal desmoplastic infantile ganglioglioma/astrocytoma (DIA/DIG) has rarely been reported. Here, two cases have been presented, reviewing the literature and proposed treatment algorithms for this rare tumor.

Patients And Methods: We report two patients diagnosed with multifocal DIA/DIGs in West China Hospital. Read More

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Optic Neuropathy Revealing Severe Superficial Siderosis in the Setting of Long-standing Low-grade Intracranial Neoplasm.

Neuroophthalmology 2022 2;46(3):171-177. Epub 2021 Aug 2.

Ophthalmology Department, Cliniques Universitaires Saint-Luc, Brussels, Belgium.

Two cases of optic neuropathy due to superficial siderosis (SS) are reported in two patients, aged 29 and 38 years, operated for intracranial neoplasms, the first one with a desmoplasic infantile ganglioglioma excised in 1991, and the other one with a pilocytic astrocytoma, operated on in 1997, 1998 and 2016. Both patients presented with progressive loss of visual acuity, as a result of bilateral optic nerve atrophy, as well as unsteadiness, ataxic gait and hearing loss. Magnetic resonance imaging (MRI) of the brain and spine, including gradient echo (GRE) T2-weighted acquisitions, revealed thin optic nerves and strong hypointensity with susceptibility artefacts corresponding to haemosiderin deposits within the meningeal layers of the spine, the infra- and supratentorial spaces of the brain and the peri-optic sheaths in both patients. Read More

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Uncommon Glioneuronal Tumors: A Radiologic and Pathologic Synopsis.

AJNR Am J Neuroradiol 2022 May 5. Epub 2022 May 5.

From the Department of Pediatric Radiology (A.V., B.C.d.A.T.), Hospital Pequeno Príncipe, Curitiba, Paraná, Brazil.

Glioneuronal tumors are characterized exclusively by neurocytic elements (neuronal tumors) or a combination of neuronal and glial features (mixed neuronal-glial tumors). Most of these tumors occur in young patients and are related to epilepsy. While ganglioglioma, dysembryoplastic neuroepithelial tumor, and desmoplastic infantile tumor are common glioneuronal tumors, anaplastic ganglioglioma, papillary glioneuronal tumor, rosette-forming glioneuronal tumor, gangliocytoma, and central neurocytoma are less frequent. Read More

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Infantile Spasms, Clinical Manifestations of a Rare Brain Tumor: A Case Report and Literature Review.

Iran J Child Neurol 2022 14;16(2):161-166. Epub 2022 Mar 14.

Student Research Committee, School of Medicine, Babol University of Medical Sciences, Babol, Iran.

Desmoplastic infantile ganglioglioma (DIG) has a favorable prognosis and is classified as a benign infantile brain tumor. The DIG is more common in children under 2 years of age than in other age groups. This report introduces a 5. Read More

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[Long-term epilepsy-associated tumors].

Zh Nevrol Psikhiatr Im S S Korsakova 2022 ;122(4):127-134

Research Center of Neurology, Moscow, Russia.

Objective: The goal of this review is to summarize data concerning radiological and histological diagnosis of epileptogenic tumors, as well as to discuss their surgical treatment.

Material And Methods: PubMed literature database was searched for relevant articles, we also used our own clinical experience.

Results: Benign glioneuronal tumors are the second most common cause of drug resistant epilepsy in adults after hippocampal sclerosis. Read More

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Upfront Molecular Targeted Therapy for the Treatment of BRAF-Mutant Pediatric High-Grade Glioma.

Neuro Oncol 2022 Apr 9. Epub 2022 Apr 9.

Pediatric Neuro-Oncology Service, Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, New York.

Background: The prognosis for patients with pediatric high-grade glioma (pHGG) is poor despite aggressive multi-modal therapy. Objective responses to targeted therapy with BRAF inhibitors have been reported in some patients with recurrent BRAF-mutant pHGG but are rarely sustained.

Methods: We performed a retrospective, multi-institutional review of patients with BRAF-mutant pHGG treated with off-label BRAF +/- MEK inhibitors as part of their initial therapy. Read More

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Ganglioglioma revealed by spontaneous intracerebral hematoma: A cohort study.

Neurochirurgie 2022 Mar 4. Epub 2022 Mar 4.

Department of neurosurgery, CHU Caen, 14000 Caen, France; Medical School, Université Caen Normandie, 14000 Caen, France; UNICAEN, Inserm, U1237, PhIND "Physiopathology and Imaging of Neurological Disorders", Institut Blood and Brain Caen-Normandie, Cyceron, Normandie université, 14000 Caen, France.

Background: Gangliogliomas are rare tumors of the central nervous system. Intracerebral hemorrhage (ICH) is a frequent pathological event, rarely related to intracranial tumor. Here we report a cohort of 14 gangliogliomas, 3 of which were revealed by ICH. Read More

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Ganglioglioma with novel molecular features presenting in a child with Allan-Herndon-Dudley syndrome.

BMJ Case Rep 2022 Mar 2;15(3). Epub 2022 Mar 2.

Neurosciences and Pediatrics, University of California San Diego, La Jolla, California, USA

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Rare simultaneous occurrence of a ganglioglioma and diffuse astrocytoma with distinct molecular features in a teenager with neurofibromatosis type 1.

BMJ Case Rep 2022 Feb 28;15(2). Epub 2022 Feb 28.

Neurosciences and Pediatrics, University of California San Diego, La Jolla, California, USA

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February 2022

The molecular characteristics of low-grade and high-grade areas in desmoplastic infantile astrocytoma/ganglioglioma.

Neuropathol Appl Neurobiol 2022 06 1;48(4):e12801. Epub 2022 Mar 1.

Department of Pathology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.

Aims: Desmoplastic infantile astrocytomas and gangliogliomas (DIA/DIGs) are rare brain tumours of infancy. A distinctive feature of their histopathology is a combination of low-grade and high-grade features. Most DIA/DIGs can be surgically resected and have a good prognosis. Read More

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A case of ganglioglioma grade 3 with H3 K27M mutation arising in the medial temporal lobe in an elderly patient.

Neuropathology 2022 Jun 20;42(3):197-203. Epub 2022 Feb 20.

Department of Neurosurgery, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.

The mutation p.K27M in H3F3A (H3 K27M mutation) is mainly detected in diffuse midline glioma. However, recent studies have demonstrated that H3 K27M mutation could also be observed in a subset of gangliogliomas. Read More

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Adult gangliocytoma arising within the lateral ventricle: A case report and review of the literature.

Surg Neurol Int 2022 12;13:11. Epub 2022 Jan 12.

Department of Surgery, Section of Neurosurgery, Max Rady College of Medicine, University of Manitoba, Canada.

Background: Gangliocytomas are rare neuronal tumors with an incidence of <1% of all central nervous system (CNS) neoplasms. They occur mostly in the pediatric age group, localizing within the cerebral cortex, most often the temporal lobe.

Case Description: We report a case of an intracranial gangliocytoma arising within the lateral ventricle in a 66-year-old female. Read More

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January 2022

Anaplastic ganglioglioma originating from the medulla oblongata: case report.

Transl Cancer Res 2021 Jun;10(6):3059-3066

Department of Neurosurgery, The Third Affiliated Hospital of Soochow University, Changzhou, China.

Ganglioglioma (GG) is a rare kind of intracranial tumor with low potential malignancy (WHO grade I), which could occur in any part of the brain. However, a patient with anaplastic ganglioglioma (WHO grade III) in the medulla oblongata is a more peculiar and rare clinical case. In our report, we presented a case of a 45-year-old man with anaplastic ganglioglioma (WHO grade III) in the medulla oblongata, who was perplexed with dysphagia, choking and left-sided numbness for two and a half years. Read More

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Heterogeneity and excitability of BRAFV600E-induced tumors is determined by Akt/mTOR-signaling state and Trp53-loss.

Neuro Oncol 2022 May;24(5):741-754

Institute of Neuropathology, Section for Translational Epilepsy Research, Medical Faculty, University of Bonn, Bonn, Germany.

Background: Developmental brain tumors harboring BRAFV600E somatic mutation are diverse. Here, we describe molecular factors that determine BRAFV600E-induced tumor biology and function.

Methods: Intraventricular in utero electroporation in combination with the piggyBac transposon system was utilized to generate developmental brain neoplasms, which were comprehensively analyzed with regard to growth using near-infrared in-vivo imaging, transcript signatures by RNA sequencing, and neuronal activity by multielectrode arrays. Read More

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Negative or positive imaging: ganglioglioma in a boy with epilepsy.

Br J Neurosurg 2021 Nov 25:1-3. Epub 2021 Nov 25.

Neurosurgery Department, Capital Institute of Pediatrics, Beijing, China.

Ganglioglioma is a rare primary tumour of the central nervous system, which characteristically contain both neuronal and glial neoplastic components mainly in children and adolescents. The most common clinical presentation is refractory epilepsy. The imaging findings of ganglioglioma are obvious and varied. Read More

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November 2021

Treatment of V600E mutated ganglioglioma of the third ventricle with dabrafenib.

Surg Neurol Int 2021 19;12:529. Epub 2021 Oct 19.

Department of Neurosurgery, Christchurch, New Zealand.

Background: Ganglioglioma (GG) of the third ventricle is rare. Surgical excision of tumors in this location is associated with high morbidity due to nearby eloquent brain centers. Alternative treatments, when available, should be considered to reduce risks of surgical treatment. Read More

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October 2021

Ganglioglioma Arising from the Septum Pellucidum.

J Neurosci Rural Pract 2021 Oct 16;12(4):807-810. Epub 2021 Sep 16.

Department of Neurosurgery, Annapurna Neurological Institute and Allied Sciences, Maitighar, Kathmandu, Nepal.

A 24-year-old gentleman presented to us with complaints of occasional headache for 2 years. Magnetic resonance imaging showed enhancing supra sellar mass with nonenhancing cystic components, extending superiorly up to the body of bilateral lateral ventricle, laterally displacing septum pellucidum, and compressing the third ventricle with obstructive hydrocephalus. Hormone profile depicted adrenocorticotropic hormone <5. Read More

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October 2021

Large Parenchymal Perianeurysmal Cyst: A Case Report.

J Neurosci Rural Pract 2021 Oct 7;12(4):800-803. Epub 2021 Sep 7.

Department of Neuropathology, National Institute of Mental Health and Neurosciences (NIMHANS), Bengaluru, Karnataka, India.

Parenchymal perianeurysmal cysts are rare. We report a case of 50-year-old woman who presented with persistent headaches and episodes of vomiting for the last 2 months. Magnetic resonance imaging of the brain showed a well-defined solitary cystic lesion with a mural nodule measuring 5. Read More

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October 2021

A Rare Case of Posterior Fossa Tumor and Central Precocious Puberty: Case Presentation and Review of the Literature.

Neurol Int 2021 Oct 20;13(4):535-540. Epub 2021 Oct 20.

Division of Neurosurgery, Department of Basic Medical Sciences, Neurosciences and Sense Organs, University "Aldo Moro" of Bari, 70124 Bari, Italy.

Central precocious puberty (CPP) is a condition that causes early gonadotropin-dependent sexual development; CPP is idiopathic in girls in most cases, whereas more than 50% of boys have an identifiable etiology. We conducted a qualitative systematic review following the ENTREQ (enhancing transparency in reporting the synthesis of qualitative research) framework. A search was made in MEDLINE/Pubmed and MeSH Database using the terms "precocious puberty" AND "brain tumor" OR "posterior fossa tumor" OR "cerebellar tumor" OR "infratentorial tumor", identifying five cases of pediatric patients with infratentorial tumors and CPP and a case of cerebellar ganglioglioma without hypothalamic-pituitary-gonadal axis involvement and/or intracranial hypertension. Read More

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October 2021

An Unusual Ganglioglioma with Pseudopapillary Features and PRKAR2B-BRAF Fusion.

J Neuropathol Exp Neurol 2021 10;80(10):1000-1003

Department of Pathology, National University Health System, Singapore, Singapore.

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October 2021

Gamma Knife radiosurgery as salvage therapy for gangliogliomas after initial microsurgical resection.

J Clin Neurosci 2021 Oct 5;92:98-102. Epub 2021 Aug 5.

Centre Hospitalier Regional Universitaire de Lille, Roger Salengro Hospital, Neurosurgery and Neurooncology Service Lille, France.

Introduction: Gangliogliomas (GG) are considered WHO grade I rare tumors. While they commonly manifest as temporal lobe epilepsy, they can be located anywhere in the brain. Primary treatment is complete microsurgical resection. Read More

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October 2021

Ganglioglioma of the cervicothoracic spinal cord in a patient with neurofibromatosis type 1: A case report.

Surg Neurol Int 2021 28;12:313. Epub 2021 Jun 28.

Departament of Surgical Specialities and Neurosurgery, Neurosurgery Teaching and Assistance Unit, Pedro Ernesto University Hospital, Rio de Janeiro, Brazil.

Background: Gangliogliomas are rare tumors of the central nervous system. They are usually located intracranially and rarely in the spinal cord. There is no clear correlation between this tumor and neurofibromatosis type 1 (NF1) with only four cases described. Read More

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A Rare Case of a High-Grade Astroblastoma with 5-Year Follow-up.

Asian J Neurosurg 2021 Jan-Mar;16(1):183-186. Epub 2021 Feb 23.

Department of Neurosurgery, Sri Ramachandra Institute of Higher Education and Research, Chennai, Tamil Nadu, India.

Astroblastoma is a very rare glial tumor derived from astroblasts. It has been controversial in terms of its features and diagnosis. The objective of this report is to present the findings of the high-grade astroblastoma with a good prognosis in a 21-year-old female who presented to us with diplopia and headache. Read More

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February 2021

A Rare Case of a Congenital Nasopharyngeal Ganglioglioma With Dyspnea in a 1-Month-Old Male Infant: A Case Report.

Front Pediatr 2021 10;9:690492. Epub 2021 Jun 10.

Department of Otolaryngology Head and Neck Surgery, Shengjing Hospital of China Medical University, Shenyang, China.

A ganglioglioma (GG), a tumor with both neuronal and astrocytic components, rarely occurs outside the central nervous system. We present the first reported case of a 1-month-old male with a congenital nasopharyngeal GG, nasal congestion, and dyspnea; we include the operative video. Magnetic resonance imaging was used to explore whether the tumor communicated with the intracranial space. Read More

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Sustained Tumor Control With MAPK Inhibition in V600-Mutant Adult Glial and Glioneuronal Tumors.

Neurology 2021 08 4;97(7):e673-e683. Epub 2021 Jun 4.

From Sorbonne Université (G.B., L.B., C.D., A.I., J.-Y.D., K.H.-X., F.B., M.S., M.T., A.L.D.S.), Inserm, CNRS, UMR S 1127, Institut du Cerveau et de la Moelle Épinière, and AP-HP Hôpitaux Universitaires La Pitié Salpêtrière-Charles Foix, Service de Neurologie 2-Mazarin, Paris, France; Radiation Therapy Unit (L.B.), Imaging and Medical Physics Department, Veneto Institute of Oncology, IOV-IRCCS, Padua, Italy; Drug Development Department (C.B.), Institut Gustave Roussy and Université Paris-Saclay, Villejuif; Department of Neuroncology (F.D.), Hôpital Neurologique Pierre Wertheimer, Hospices Civils de Lyon, Bron; Department of Neurology (D.G., N.Y., A.L.D.S.), Department of Neurosurgery (S.G.), Service de Pharmacie (C.L.-S.), Department of Oncology (S.S.), Department of Neuroradiology (J.G.), and Department of Pathology (C.V.), Hôpital Foch, Suresnes, France; Neuro-oncology Unit (M.E., A.S.), Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy; Service de Neurologie (L.N.T.), Centre Hospitalier Perpignan, France; Radiation Oncology (F.P.), Department of Medicine and Oncology, University Hospital, Pisa, Italy; Clinical Research Unit (P.T.), Institut Curie, Paris; Department of Nuclear Medicine (A.K.), AP-HP GH Pitié-Salpêtrière, Paris; Department of Diagnostic Radiology (S.A.), Institut Gustave Roussy, Villejuif, France; Neuroradiology Unit (E.S., J.S.), Fondation Ophtalmologique Adolphe de Rothschild, Paris; Department of Pathology (D.M.), Eastern Hospital Group, Lyon Civil Hospices; Department of Neuropathology (F.B.), AP-HP, Hôpital de la Pitié-Salpêtrière; and Onconeurotek Tumor Bank (F.B., M.S.), Institut du Cerveau et de la Moelle Épinière (ICM), Paris, France. Dr. Berzero is currently at Neurology Unit (G.B.), IRCCS San Raffaele Scientific Institute, Milan, Italy; and Dr. Gaillard is currently at the Department of Neurosurgery, AP-HP, Groupe hospitalier Pitié-Salpêtrière, Paris.

Objective: To assess whether RAF and MEK inhibitors (RAFi/MEKi) can provide long-term clinical benefit in adult patients with V600-mutant glial and glioneuronal tumors (GGNTs), we analyzed tumor response and long-term outcome in a retrospective cohort.

Methods: We performed a retrospective search in the institutional databases of 6 neuro-oncology departments for adult patients with recurrent or disseminated V600-mutant GGNTs treated with RAFi/MEKi.

Results: Twenty-eight adults with recurrent or disseminated V600-mutant gangliogliomas (n = 9), pleomorphic xanthoastrocytomas (n = 9), and diffuse gliomas (n = 10) were included in the study. Read More

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Cyclin D1 expression in ganglioglioma, pleomorphic xanthoastrocytoma and pilocytic astrocytoma.

Exp Mol Pathol 2021 08 19;121:104652. Epub 2021 May 19.

University Hospital of Saint Etienne, North Hospital, Department of Pathology, Avenue Albert Raimond, 42055, Saint Etienne CEDEX 2, France; Corneal Graft Biology, Engineering and Imaging Laboratory, BiiGC, EA2521, Federative Institute of Research in Sciences and Health Engineering, Faculty of Medicine, Jean Monnet University, Saint-Etienne, France.

Ganglioglioma, pleomorphic xanthoastrocytoma (PXA) and pilocytic astrocytoma are rare brain neoplasms with frequent activation of mitogen-activated protein (MAP) kinase pathway. A downstream marker of MAP-kinase pathway activation is cyclin D1. However, the expression of cyclin D1 has not been studied in the differential diagnosis between these brain tumors. Read More

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Infra-Occipital Supra-Tentorial Approach for Resection of Low-Grade Tumor of the Left Lingual Gyrus: 2-Dimensional Operative Video.

Oper Neurosurg (Hagerstown) 2021 Aug;21(3):E257-E258

Neurosurgery Unit, Department of Neurosciences, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.

Surgical treatment of lesions involving the postero-medial occipito-temporal region is challenging because of high risk of morbidity due to damage or excessive retraction of critical neuro-vascular structures, especially within the dominant hemisphere.1-3  Here, we describe the case of a 17-yr-old patient who underwent resection of an epileptogenic low-grade tumor located within the left-dominant lingual gyrus. Seizures were characterized, as a first symptom, by right-sided simple visual hallucination that pointed to the left pericalcarine region, corresponding to the lesion location. Read More

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Alectinib-responsive infantile anaplastic ganglioglioma with a novel VCL-ALK gene fusion.

Pediatr Blood Cancer 2021 09 21;68(9):e29122. Epub 2021 May 21.

Department of Pediatrics, Graduate School of Medical Sciences, Kyushu University, Higashi-ku, Fukuoka, Japan.

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September 2021