682 results match your criteria Imaging in Ganglioglioma


Ganglioglioma Arising from the Septum Pellucidum: Case Report and Review of the Literature.

Pediatr Neurosurg 2019 Jan 8:1-10. Epub 2019 Jan 8.

Department of Neurological Surgery, University of Virginia Health Science Center, University of Virginia, Charlottesville, Virginia,

Background: Gangliogliomas are low-grade neoplasms that typically affect patients under the age of 30 and present with epilepsy and symptoms of mass effect. Here, we report a case of an intraventricular ganglioglioma involving the septum pellucidum in a pediatric patient with history of optic glioma. Only one other pediatric intraventricular ganglioglioma arising from the septum pellucidum has been reported previously. Read More

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https://www.karger.com/Article/FullText/495043
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http://dx.doi.org/10.1159/000495043DOI Listing
January 2019
11 Reads
0.497 Impact Factor

Discrimination of epileptogenic lesions and perilesional white matter using diffusion tensor magnetic resonance imaging.

Neuroradiol J 2018 Nov 21:1971400918813991. Epub 2018 Nov 21.

1 Department of Neuroradiology, Medical Centre - University of Freiburg, Faculty of Medicine, University of Freiburg, Germany.

The aim of this study was to evaluate whether ganglioglioma (GGL), dysembryoplastic neuroepithelial tumour (DNET) and FCD (focal cortical dysplasia) are distinguishable through diffusion tensor imaging. Additionally, it was investigated whether the diffusion measures differed in the perilesional (pNAWM) and in the contralateral normal appearing white matter (cNAWM). Six GGLs, eight DNETs and seven FCDs were included in this study. Read More

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http://dx.doi.org/10.1177/1971400918813991DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6327366PMC
November 2018
2 Reads

Cervicomedullary Ganglioglioma in a Child - A Case Report.

Prague Med Rep 2018 ;119(2-3):122-127

Department of Neurosurgery, Iran University of Medical Sciences, Rasool Akram Hospital, Tehran, Iran.

Ganglioglioma is a benign slow-growing neoplasm that most frequently occurs at the supratentorial region. Nevertheless, there are occasional reports of ganglioglioma occurring in the brainstem and spinal cord. Here we report a rare case of the craniocervical ganglioglioma. Read More

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https://pmr.lf1.cuni.cz/119/2/0122/
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http://dx.doi.org/10.14712/23362936.2018.12DOI Listing
January 2018
10 Reads

Stereotactic Brain Biopsy in Eloquent Areas Assisted by Navigated Transcranial Magnetic Stimulation: a Technical Case Report.

Oper Neurosurg (Hagerstown) 2018 Oct 26. Epub 2018 Oct 26.

Department of Neurosurgery, Karolinska University Hospital, Stockholm, Sweden.

Background And Importance: Stereotactic brain biopsy (SB) is an important part of the neurosurgical armamentarium, with the possibility of achieving histopathological diagnosis in otherwise inaccessible lesions of the brain. Nevertheless, the procedure is not without the risk of morbidity, which is especially true for lesions in eloquent parts of the brain, where even a minor adverse event can result in significant deficits. Navigated transcranial magnetic stimulation (nTMS) is widely used to chart lesions in eloquent areas, successfully guiding maximal safe resection, while its potential role in aiding with the planning of a stereotactic biopsy is so far unexplored. Read More

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https://academic.oup.com/ons/advance-article/doi/10.1093/ons
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http://dx.doi.org/10.1093/ons/opy321DOI Listing
October 2018
9 Reads

CD34 Expression in Low-Grade Epilepsy-Associated Tumors: Relationships with Clinicopathologic Features.

World Neurosurg 2019 Jan 9;121:e761-e768. Epub 2018 Oct 9.

Neurosurgery Unit, Department of Neuroscience, Bambino Gesù Children's Hospital IRCCS, Rome, Italy.

Objective: To analyze relationships between CD34 expression and several demographic, clinical, and pathologic features in patients with histopathologic evidence of low-grade epilepsy-associated tumors who underwent epilepsy surgery.

Methods: A retrospective study enrolling 187 patients with low-grade epilepsy-associated tumors who underwent surgery between January 2009 and June 2015 at 8 Italian epilepsy surgery centers was conducted. All cases were histologically diagnosed according to the World Health Organization classification of central nervous system tumors. Read More

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http://dx.doi.org/10.1016/j.wneu.2018.09.212DOI Listing
January 2019
1 Read

Inflammatory myofibroblastic lung tumor transforming into intracranial desmoplastic noninfantile ganglioglioma: A case report and literature review.

Medicine (Baltimore) 2018 Oct;97(40):e12668

Department of Neurosurgery, West China Hospital, Sichuan University, Chengdu.

Rationale: Inflammatory myofibroblastic tumor (IMT) of the lung often arises from excessive inflammatory response. It is one of the rare benign tumors of the lung, while desmoplastic noninfant gangliogliomas (DNIG), on the contrary, are rare intracranial benign tumors often seen in children within the first one and a half years of life.

Patient Concerns: We present a 12-year-old girl with 2 months history of none productive cough and right-sided chest pain. Read More

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http://Insights.ovid.com/crossref?an=00005792-201810050-0006
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http://dx.doi.org/10.1097/MD.0000000000012668DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6200452PMC
October 2018
4 Reads
5.723 Impact Factor

Post-treatment maturation of medulloblastoma in children: two cases and a literature review.

J Int Med Res 2018 Nov 1;46(11):4781-4790. Epub 2018 Oct 1.

Department of Neurosurgery, Children's Hospital of Chongqing Medical University, Chongqing, China.

We herein report two cases of post-treatment maturation of medulloblastoma (MB). We also conducted a literature review to summarize the clinical and pathologic features of MB maturation. From January 1992 to February 2017, 52 patients with MB underwent surgical resection followed by radiotherapy and chemotherapy. Read More

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http://dx.doi.org/10.1177/0300060518788251DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6259389PMC
November 2018
14 Reads

[BRAF V600E mutation and clinicopathologic characteristics in 250 cases of brain tumors associated with epilepsy].

Zhonghua Bing Li Xue Za Zhi 2018 Sep;47(9):664-670

Department of Pathology, Capital Medical University, Beijing 100010, China.

To investigate the clinicopathologic characteristics and BRAF V600E mutation of brain tumors associated with epilepsy. Totally 250 patients with brain tumors associated with epilepsy were included from March 2008 to August 2017 retrospectively at Sanbo Brain Hospital, Capital Medical University.The clinical manifestations, histological features and BRAF V600E mutation results were collected and analyzed. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0529-5807.2018.09.003DOI Listing
September 2018
6 Reads

Meningioma mimicking an intraparenchymal cystic tumor.

Nagoya J Med Sci 2018 Aug;80(3):431-434

Department of Neurosurgery, Sapporo Medical University School of Medicine, Sapporo, Japan.

Meningiomas rarely exhibit cystic lesions with mural nodules, and may be misdiagnosed as intraparenchymal cystic tumors. We herein present a 64-year-old woman with a cystic lesion and enhancing mural nodule in the left temporal lobe accompanied by peritumoral brain edema. Differential diagnoses included low-grade gliomas, hemangioblastoma, and cystic meningioma. Read More

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http://dx.doi.org/10.18999/nagjms.80.3.431DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6125649PMC
August 2018
3 Reads

Pediatric primary anaplastic ganglioglioma with malignant neuronal component.

Turk J Pediatr 2018 ;60(1):102-106

Departments of Pediatrics, Cumhuriyet University Faculty of Medicine, Sivas, Turkey.

Kaymak-Cihan M, Erdiş E, Bozkurt S, Ünver-Korğalı E. Pediatric primary anaplastic ganglioglioma with malignant neuronal component. Turk J Pediatr 2018; 60: 102-106. Read More

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http://dx.doi.org/10.24953/turkjped.2018.01.017DOI Listing
January 2019
10 Reads

Pediatric Intracranial Anaplastic Gangliogliomas: Illustrative Case and Systematic Review.

World Neurosurg 2018 Nov 8;119:220-231. Epub 2018 Aug 8.

Department of Neurosurgery, Mongi Ben Hamida National Institute of Neurology Tunis, Faculty of Medicine, University of Tunis El Manar, Tunis, Tunisia.

Objective: We present an illustrative case of pediatric intracranial anaplastic ganglioglioma and systematically reviewed the current reported data of anaplastic ganglioglioma in the pediatric population.

Methods: A comprehensive literature search for our review was conducted using PubMed, Scopus, Web of Science, PsycINFO, Cochrane, and Embase databases. The search terms included "ganglioglioma," "anaplastic," "pediatrics," "children," and "intracranial. Read More

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http://dx.doi.org/10.1016/j.wneu.2018.07.278DOI Listing
November 2018
2 Reads

Surgical Treatment of Lesional Mesial Temporal Lobe Epilepsy.

J Epilepsy Res 2018 Jun 30;8(1):6-11. Epub 2018 Jun 30.

Division of Pediatric Neurosurgery, Seoul National University Children's Hospital, Seoul National University College of Medicine, Seoul, Korea.

Lesional mesial temporal lobe epilepsy (mTLE) concerns a lesion other than mesial hippocampal sclerosis present in the mesial temporal lobe and causing seizures. The lesions are usually composed of focal cortical dysplasia (FCD) or are tumorous. These are good candidates for surgical treatment. Read More

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http://dx.doi.org/10.14581/jer.18002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6066696PMC
June 2018
7 Reads

Ganglioglioma of the adenohypophysis mimicking pituitary adenoma: A case report and review of the literature.

Medicine (Baltimore) 2018 Jul;97(30):e11583

Department of Neurosurgery, The Second Affiliated Hospital, School of Medicine.

Introduction: Ganglioglioma is a generally benign tumor, mostly occurring in patients <30 years old. Temporal lobe is most frequently involved. Up to now, only 3 cases were reported of ganglioglioma in the pituitary gland, all being confined to the neurohypophysis. Read More

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http://dx.doi.org/10.1097/MD.0000000000011583DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6078729PMC
July 2018
11 Reads

Magnetic resonance imaging findings of mixed neuronal-glial tumors with pathologic correlation: a review.

Acta Neurol Belg 2018 Sep 9;118(3):379-386. Epub 2018 Jul 9.

Department of Neurosurgery, Bahçeşehir University School of Medicine, Göztepe Medical Park Training and Education Hospital, Istanbul, Turkey.

Mixed neuronal-glial tumors are rare, and MRI diagnosis of them presents a challenge. In this review, we discuss the MRI findings of ganglioglioma, anaplastic ganglioglioma, desmoplastic infantile ganglioglioma, papillary glioneuronal tumor, rosette-forming glioneuronal tumor, and primary diffuse leptomeningeal glioneuronal tumor with clinicopathologic correlation. There is overlap of imaging features both with each other and some other tumors, which complicates diagnosis. Read More

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http://dx.doi.org/10.1007/s13760-018-0981-1DOI Listing
September 2018
16 Reads

Novel suprasellar location of desmoplastic infantile astrocytoma and ganglioglioma: a single institution's experience.

J Neurosurg Pediatr 2018 Oct 6;22(4):397-403. Epub 2018 Jul 6.

Departments of 4 Neurologic Surgery.

Objective: The aim of this study was to describe the clinical presentation, imaging appearance, and differential outcomes based on tumor location in 7 patients with desmoplastic infantile astrocytoma and desmoplastic infantile gangliogliomas (DIA/DIG).

Methods: Data of 7 patients with histopathology-proven DIA/DIGs and preoperative imaging were retrospectively reviewed, and age, sex, clinical presentation, imaging characteristics, tumor location, surgical procedure, postoperative morbidity, and overall mortality were recorded.

Results: Two subgroups of patients with DIA/DIGs were found to exist based on whether their tumor was located in the cerebral hemispheres or suprasellar region. Read More

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http://dx.doi.org/10.3171/2018.4.PEDS17638DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6261346PMC
October 2018
20 Reads
1.370 Impact Factor

Cerebellopontine Angle Anaplastic Ganglioglioma Masquerading as Vestibular Schwannoma: Unusual Entity.

World Neurosurg 2018 Sep 19;117:221-224. Epub 2018 Jun 19.

Department of Neuro-Surgery, Govind Ballabh Pant Institute of Postgraduate Medical Education and Research, New Delhi, India.

Background: Anaplastic gangliogliomas at the cerebellopontine angle (CPA) are exceptionally rare with only a few reported cases in published literature. These are composed of atypical ganglion cells and astrocytes accounting for nearly 1% of all central nervous system tumors. The authors report the case of anaplastic ganglioglioma in an adult patient presenting as a CPA mass lesion. Read More

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http://dx.doi.org/10.1016/j.wneu.2018.06.054DOI Listing
September 2018
13 Reads
2.420 Impact Factor

The genetic landscape of ganglioglioma.

Acta Neuropathol Commun 2018 Jun 7;6(1):47. Epub 2018 Jun 7.

Department of Pathology, University of California, San Francisco, CA, USA.

Ganglioglioma is the most common epilepsy-associated neoplasm that accounts for approximately 2% of all primary brain tumors. While a subset of gangliogliomas are known to harbor the activating p.V600E mutation in the BRAF oncogene, the genetic alterations responsible for the remainder are largely unknown, as is the spectrum of any additional cooperating gene mutations or copy number alterations. Read More

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http://dx.doi.org/10.1186/s40478-018-0551-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5992851PMC
June 2018
4 Reads
1 Citation

Subtotal Resection of an Anaplastic Ganglioglioma in Pregnancy.

Case Rep Obstet Gynecol 2018 10;2018:4606354. Epub 2018 May 10.

Department of Obstetrics and Gynecology, Houston Methodist Hospital, Houston, TX, USA.

Background: Anaplastic ganglioglioma is a rare malignant brain tumor associated with high morbidity and mortality. The diagnosis of a central nervous system malignancy in the early 3rd trimester presents management challenges to both neurosurgeons and obstetricians.

Case: A 33-year-old woman, gravida 2 para 1, presented at 28 6/7 weeks with four months of worsening headaches, nausea, vomiting, and mental status changes due to a 7. Read More

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http://dx.doi.org/10.1155/2018/4606354DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5971236PMC
May 2018
2 Reads

Bipolar electro-coagulation with cortextomy in the treatment of insular and insulo-opercular epilepsy explored by stereoelectro-encephalography.

Epilepsy Res 2018 09 24;145:18-26. Epub 2018 May 24.

Department of Neurosurgery, Sanbo Brain Hospital, Capital Medical University, Beijing, PR China; Beijing Key Lab. of Epilepsy, Beijing, PR China; Center of Epilepsy, Beijing Institute for Brain Disorders, Beijing, PR China. Electronic address:

Objective: The diagnosis and treatment of insular and insulo-opercular epilepsy remain underexplored because the insula is covered by the insulo-opercular and a dense vascular curtain. Stereoelectro-encephalography (SEEG) is a reliable and recommended technique for locating the epileptic zone, especially in insular and insulo-opercular regions (Isnard et al., 2000, 2004). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09201211173057
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http://dx.doi.org/10.1016/j.eplepsyres.2018.05.007DOI Listing
September 2018
4 Reads

Intraventricular Ganglioglioma Presenting with Spontaneous Hemorrhage.

Acta Med Port 2018 Mar 29;31(3):170-175. Epub 2018 Mar 29.

Anatomical Pathology Unit. Hospital CUF Descobertas. Lisboa. Instituto CUF de Oncologia. Lisboa, Portugal.

Intraventricular gangliogliomas presenting with spontaneous hemorrhage are rare. Due to high density of important tracts lateral to the ventricular atrium, the intraparietal trans sulcal approach is a good option to remove lesions in this location. These tracts are displaced and sometimes destroyed by the presence of large masses. Read More

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http://dx.doi.org/10.20344/amp.8943DOI Listing
March 2018
4 Reads

Perioperative Multimodal Evaluation and Surgical Tactics of Tumor-Related Epilepsy: 2-Dimensional Operative Video.

Oper Neurosurg (Hagerstown) 2018 Nov;15(5):E55-E56

Neurosurgery Department of Huashan Hospital, Fudan University, Shanghai, China.

Treatment of tumor-related epilepsy (TRE), especially for tumors near critical areas, requires surgeons to strike a balance between the epileptic benefit and functional outcome after surgery. Here, we present a case in which multimodal evaluation facilitated the achievement of such surgical balance. Informed patient consent was obtained. Read More

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http://dx.doi.org/10.1093/ons/opy098DOI Listing
November 2018
5 Reads

EWSR1-PATZ1 gene fusion may define a new glioneuronal tumor entity.

Brain Pathol 2019 01 13;29(1):53-62. Epub 2018 Jul 13.

Department of Pathology, IUCT-Oncopole, Toulouse University Hospital, Toulouse, France.

We investigated the challenging diagnostic case of a ventricular cystic glioneuronal tumor with papillary features, by RNA sequencing using the Illumina TruSight RNA Fusion panel. We did not retrieve the SLC44A1-PRKCA fusion gene specific for papillary glioneuronal tumor, but an EWSR1-PATZ1 fusion transcript. RT-PCR followed by Sanger sequencing confirmed the EWSR1-PATZ1 fusion. Read More

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http://dx.doi.org/10.1111/bpa.12619DOI Listing
January 2019
7 Reads

Intractable Yawning as a Predominant Symptom of Temporal Lobe Ganglioglioma: Case Report and Review of Literature.

Asian J Neurosurg 2018 Jan-Mar;13(1):102-104

Department of Neurosurgery, Government Medical College, Calicut, Kerala, India.

Yawning, a physiologic reflex exhibited by vertebrates, is seldom noticed as a symptom of a disease. Not too often is a patient aware of it as a symptom, unless it is of such a distressing nature to seek attention. In this situation, to distinguish between normal and abnormal behavior would pose a diagnostic dilemma for the attending physician. Read More

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http://dx.doi.org/10.4103/1793-5482.180898DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5820860PMC
March 2018
6 Reads

Suprasellar Ganglioglioma: Expanding the Differential Diagnosis.

Case Rep Pathol 2018 1;2018:9486064. Epub 2018 Feb 1.

Department of Pathology, Augusta University-Medical College of Georgia, 1120 Fifteenth Street, Augusta, GA 30912-3600, USA.

This case study describes a young man with symptoms suggestive of the presence of a space-occupying lesion within the cranial cavity. Imaging studies confirmed a lesion in the suprasellar region and surgical intervention to remove the tumor yielded an unexpected diagnosis. Neuroimaging characteristics and histopathology including immunohistochemistry are described. Read More

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http://dx.doi.org/10.1155/2018/9486064DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5816866PMC
February 2018
5 Reads

Lesional Temporal Lobe Epilepsy: Beware the Deceitful "Panic Attack".

World Neurosurg 2018 Mar 28;111:197-200. Epub 2017 Dec 28.

Department of Neurosurgery, Lenox Hill Hospital, Hofstra Northwell School of Medicine, New York, New York, USA. Electronic address:

Background: Ganglioglioma is a rare, benign, intraaxial glioneuronal tumor but a relatively common cause of pharmacoresistant temporal lobe epilepsy (TLE). Given its often nonspecific neuropsychiatric manifestations and frequently negative electroencephalographic workup, TLE can be easily misdiagnosed as a psychiatric disorder, particularly panic attacks.

Case Description: We present a case of a 17-year-old boy who was found to have lesional TLE secondary to a left temporal ganglioglioma, 5 years after having been misdiagnosed with panic disorder and having undergone ineffective and unnecessary psychotherapy. Read More

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http://dx.doi.org/10.1016/j.wneu.2017.12.124DOI Listing
March 2018
5 Reads

Dysplasia and overgrowth: magnetic resonance imaging of pediatric brain abnormalities secondary to alterations in the mechanistic target of rapamycin pathway.

Neuroradiology 2018 Feb 26;60(2):137-150. Epub 2017 Dec 26.

Division of Pediatric Radiology and Pediatric Neuroradiology, Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, 1800 Orleans Street, Zayed 4174, Baltimore, MD, 21287, USA.

The current classification of malformations of cortical development is based on the type of disrupted embryological process (cell proliferation, migration, or cortical organization/post-migrational development) and the resulting morphological anomalous pattern of findings. An ideal classification would include knowledge of biological pathways. It has recently been demonstrated that alterations affecting the mechanistic target of rapamycin (mTOR) signaling pathway result in diverse abnormalities such as dysplastic megalencephaly, hemimegalencephaly, ganglioglioma, dysplastic cerebellar gangliocytoma, focal cortical dysplasia type IIb, and brain lesions associated with tuberous sclerosis. Read More

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http://link.springer.com/10.1007/s00234-017-1961-5
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http://dx.doi.org/10.1007/s00234-017-1961-5DOI Listing
February 2018
17 Reads

A Novel Functional Magnetic Resonance Imaging Paradigm for the Preoperative Assessment of Auditory Perception in a Musician Undergoing Temporal Lobe Surgery.

World Neurosurg 2018 Mar 15;111:63-67. Epub 2017 Dec 15.

Faculty of Medicine and Health, University of Leeds, Leeds, United Kingdom; Department of Neurology, The Leeds Teaching Hospitals NHS Trust, Leeds, United Kingdom. Electronic address:

Background: Presurgical evaluation for temporal lobe epilepsy routinely assesses speech and memory lateralization and anatomic localization of the motor and visual areas but not baseline musical processing. This is paramount in a musician. Although validated tools exist to assess musical ability, there are no reported functional magnetic resonance imaging (fMRI) paradigms to assess musical processing. Read More

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http://dx.doi.org/10.1016/j.wneu.2017.12.018DOI Listing
March 2018
16 Reads
2.420 Impact Factor

Seizure and cognitive outcomes after resection of glioneuronal tumors in children.

Epilepsia 2018 01 26;59(1):170-178. Epub 2017 Nov 26.

Great Ormond Street Hospital, London, United Kingdom.

Objective: Glioneuronal tumors (GNTs) are well-recognized causes of chronic drug-resistant focal epilepsy in children. Our practice involves an initial period of radiological surveillance and antiepileptic medications, with surgery being reserved for those with radiological progression or refractory seizures. We planned to analyze the group of patients with low-grade GNTs, aiming to identify factors affecting seizure and cognitive outcomes. Read More

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http://dx.doi.org/10.1111/epi.13961DOI Listing
January 2018
51 Reads

Imaging features of rosette-forming glioneuronal tumours.

Clin Radiol 2018 03 13;73(3):275-282. Epub 2017 Nov 13.

Wulumuqi Middle Street 12, Department of Radiology, Huashan Hospital of Fudan University, Shanghai, China. Electronic address:

Aim: To describe the imaging features of rosette-forming glioneuronal tumours (RGNTs) to enable accurate diagnosis.

Materials And Methods: Image data and clinical findings for seven patients with histopathologically confirmed RGNTs were studied comprehensively.

Results: Six neoplasms were located near the midline and all were relatively well circumscribed. Read More

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http://dx.doi.org/10.1016/j.crad.2017.10.011DOI Listing
March 2018
2 Reads

Presentation of a meningioma in a transwoman after nine years of cyproterone acetate and estradiol intake: case report and literature review.

Gynecol Endocrinol 2018 Jun 5;34(6):456-459. Epub 2017 Nov 5.

a DIMEC , University of Bologna , Bologna , Italy.

The administration of cyproterone acetate (CPA) and estradiol is a common regimen used by male-to-female transsexuals (transwoman) to adjust their body to their gender identity. Major adverse events are uncommon in these subjects in spite of long-term, high dose cross-sex steroid treatments. We describe the occurrence of a meningioma in a transwoman treated with estrogens and CPA over a period of nine years. Read More

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http://dx.doi.org/10.1080/09513590.2017.1395839DOI Listing
June 2018
6 Reads

[Clinicopathologic features of infant dysembryoplastic neuroepithelial tumor: a case report and literature review].

Beijing Da Xue Xue Bao Yi Xue Ban 2017 10;49(5):904-909

Department of Pathology, Peking University First Hospital, Beijing 100034, China.

Dysembryoplastic neuroepithelial tumor (DNT) has traditionally been viewed as rare benign tumors that present with seizure widely considered curable with surgery alone. Most DNTs occur in childhood and young adults. However, rare reported cases occur in infants. Read More

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October 2017
19 Reads

Pathology-MRI Correlations in Diffuse Low-Grade Epilepsy Associated Tumors.

J Neuropathol Exp Neurol 2017 Dec;76(12):1023-1033

Lysholm Department of Neuroradiology in National Hospital for Neurology and Neurosurgery, London, UK; Division of Neuropathology, National Hospital for Neurology and Neurosurgery, London, UK; Department of Clinical and Experimental Epilepsy, UCL Institute of Neurology, London, UK; and Victor Horsley Department of Neurosurgery, National Hospital for Neurology and Neurosurgery, London, UK.

It is recognized that IDH mutation negative, low-grade epilepsy associated tumors (LEAT) can show diffuse growth patterns and lack the diagnostic hallmarks of either classical dysembryoplastic neuroepithelial tumors (DNT) or typical ganglioglioma. "Nonspecific or diffuse DNT" and more recently "polymorphous low-grade neuroepithelial tumor of the young" have been terms used for these entities. There are few reports on the MRI recognition of these diffuse glioneuronal tumors (dGNT), which is important in planning the extent of surgical resection. Read More

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http://dx.doi.org/10.1093/jnen/nlx090DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5939705PMC
December 2017
12 Reads

Malignant transformation and leptomeningeal spread of recurrent ganglioglioma: case report and review of literature.

Clin Imaging 2018 Mar - Apr;48:7-11. Epub 2017 Sep 20.

Department of Radiology, University of Iowa hospitals and clinics, IA, USA.

Gangliogliomas are rare, typically benign low grade tumors which usually occur in the supratentorial compartment, more commonly in the pediatric age group. Malignant transformation of a low grade ganglioglioma in the absence of prior radiation therapy is exceptionally rare with only 17 such cases previously reported. The author present an additional case of malignant transformation of recurrent ganglioglioma. Read More

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http://dx.doi.org/10.1016/j.clinimag.2017.09.011DOI Listing
August 2018
5 Reads

Cystic supratentorial mass in a middle-aged patient: MR imaging findings with histopathologic correlation.

Acta Neurol Belg 2017 12 25;117(4):909-913. Epub 2017 Sep 25.

Department of Medical Imaging, University Hospital (UZ) Gent, Gent, Belgium.

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http://link.springer.com/10.1007/s13760-017-0841-4
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http://dx.doi.org/10.1007/s13760-017-0841-4DOI Listing
December 2017
6 Reads

Ganglioglioma Progression to Combined Anaplastic Ganglioglioma and Anaplastic Pleomorphic Xanthoastrocytoma. Case Report and Literature Review.

World Neurosurg 2017 Dec 20;108:996.e17-996.e25. Epub 2017 Sep 20.

Department of Neurosurgery, Hospital Universitari de Bellvitge, l'Hospitalet de Llobregat, Barcelona, Catalonia, Spain.

Background: Composite ganglioma and pleomorphic xanthoastrocytoma with anaplastic features in both components is an extremely rare glioneuronal tumor. Five cases of anaplastic progression in the glioma component have been reported. These tumors generally affect young patients who have brain tumor-related epilepsy, which are usually located in the temporal lobe or in the cerebellum and may have associated leptomeningeal spreading. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S18788750173157
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http://dx.doi.org/10.1016/j.wneu.2017.09.072DOI Listing
December 2017
9 Reads

Atypical Presentation of a Pediatric Cerebellar Ganglioglioma.

Pediatr Neurosurg 2018 20;53(1):43-48. Epub 2017 Sep 20.

Department of Neurological Surgery, Stony Brook Medicine, Stony Brook, NY, USA.

Background/aims: Gangliogliomas (GGs) are rare central nervous system tumors occurring primarily in the supratentorial compartment with infratentorial instances most often involving the brain stem. Infratentorial GGs typically present with signs and symptoms of increased intracranial pressure (ICP), cranial nerve deficits, or focal cerebellar findings; rarely, these tumors have been associated with focal seizures.

Methods: In this report, we describe an atypical presentation of a cerebellar GG in a 20-month-old male who initially presented with syncope and emesis in the absence of electrographic evidence of seizures, radiographic evidence of hydrocephalus, or elevated ICP. Read More

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https://www.karger.com/Article/FullText/479975
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http://dx.doi.org/10.1159/000479975DOI Listing
July 2018
11 Reads
0.500 Impact Factor

tissue imaging for radiology-pathology correlation: a pilot study with a small bore 7-T MRI in a rare pigmented ganglioglioma exhibiting complex MR signal characteristics associated with melanin and hemosiderin.

J Med Imaging (Bellingham) 2017 Jul 13;4(3):036001. Epub 2017 Sep 13.

University of Winnipeg, Department of Physics, Winnipeg, Manitoba, Canada.

To advance magnetic resonance imaging (MRI) technologies further for tissue characterization with histopathologic validation, we investigated the feasibility of tissue imaging of a surgically removed human brain tumor as a comprehensive approach for radiology-pathology correlation in histoanatomically identical fashion in a rare case of pigmented ganglioglioma with complex paramagnetic properties. Pieces of surgically removed ganglioglioma, containing melanin and hemosiderin pigments, were imaged with a small bore 7-T MRI scanner to obtain T1-, T2-, and T2*-weighted image and diffusion tensor imaging (DTI). Corresponding histopathological slides were prepared for routine hematoxylin and eosin stain and special stains for melanin and iron/hemosiderin to correlate with MRI signal characteristics. Read More

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https://www.spiedigitallibrary.org/journals/journal-of-medic
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http://dx.doi.org/10.1117/1.JMI.4.3.036001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5596201PMC
July 2017
29 Reads

Discrepancy between radiological and histological findings in ganglioglioma of the optic chasm: Case report.

Surg Neurol Int 2017 11;8:146. Epub 2017 Jul 11.

Department of Neurosurgery, Shiga Medical Center for Adults, Shiga, Japan.

Background: Gangliogliomas involving the optic nerve or chiasm are extremely rare tumors, which can be confused radiologically with other neoplasms. α-[-methyl-C]-methylaminoisobutyric acid (C-MeAIB) is a new artificial amino acid positron emission tomography (PET) tracer, which is metabolically more stable and may be more specific for tumors than C-methionine. However, the utility of C-MeAIB PET in the diagnosis of brain tumors has not yet been reported. Read More

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http://dx.doi.org/10.4103/sni.sni_289_16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5523510PMC
July 2017
16 Reads

Gliosarcomas with the V600E mutation: a report of two cases and review of the literature.

J Clin Pathol 2017 Dec 3;70(12):1079-1083. Epub 2017 Aug 3.

Department of Pathology, Xuanwu Hospital Capital Medical University, Beijing, China.

Gliosarcoma, which is regarded as a variant of glioblastoma, is a rare malignant neoplasm of the central nervous system. Both its sarcomatous component and glial component are reported to share significant clinical and genetic similarities. However, gliosarcomas are considered to be characterised by a lack of the V600E mutation. Read More

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http://jcp.bmj.com/lookup/doi/10.1136/jclinpath-2017-204620
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http://dx.doi.org/10.1136/jclinpath-2017-204620DOI Listing
December 2017
9 Reads

[Pediatric brain tumors].

Radiologe 2017 Sep;57(9):728-739

Klinik für Diagnostische und Interventionelle Neuroradiologie, Universitätsklinikum des Saarlandes, Kirrberger Straße, 66421, Homburg/Saar, Deutschland.

Brain tumors differ between children and adults both in histology and localization. Malignant gliomas and meningiomas predominate in adults while medulloblastomas and low-grade astrocytomas are the most frequent brain tumors in children. More than one half (50-70%) of pediatric brain tumors have an infratentorial location but only approximately 30% in adults. Read More

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http://dx.doi.org/10.1007/s00117-017-0287-yDOI Listing
September 2017
5 Reads

Ganglioglioma of brain stem and cervicomedullary junction: A 50years review of literature.

J Clin Neurosci 2017 Oct 4;44:34-46. Epub 2017 Jul 4.

Department of Neurological Surgery, Weill Cornell Medical College and New York Presbyterian Hospital, 525 East, 68th Street, New York, NY 10065, United States.

Gangliogliomas are rare low-grade brain tumors composed of both neoplastic glial and neuronal cell elements. The treatment modalities are relatively different in this location and hence factors affecting outcome are poorly understood. We identified 142 brain stem GG patients across 46 studies. Read More

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http://dx.doi.org/10.1016/j.jocn.2017.06.021DOI Listing
October 2017
11 Reads

Ganglioglioma in the Third Ventricle: A Case Report and Literature Review.

NMC Case Rep J 2016 Jul 19;3(3):97-101. Epub 2016 May 19.

Department of Neurosurgery, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan.

Gangliogliomas typically arise in the cerebral hemispheres, but may occur rarely in the ventricles. Herein, we report a 38-year-old woman who was treated for hydrocephalus caused by a ganglioglioma of the third ventricle. Magnetic resonance imaging (MRI) revealed a heterogeneously enhanced tumor occupying the anterior part of the third ventricle. Read More

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http://dx.doi.org/10.2176/nmccrj.cr.2016-0038DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5386175PMC
July 2016
21 Reads

Hemorrhagic ganglioglioma of the third ventricle with atypical pathological findings.

Brain Tumor Pathol 2017 07 17;34(3):135-137. Epub 2017 Jun 17.

Department of Neuro-Oncology/Neurosurgery, Saitama Medical University International Medical Center, 1397-1 Yamane, Hidaka, Saitama, Japan.

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http://dx.doi.org/10.1007/s10014-017-0290-zDOI Listing
July 2017
10 Reads
2.281 Impact Factor

A Child With Progressive Leg Weakness.

Authors:
Arpita Lakhotia

Pediatr Neurol 2017 09 18;74:104-105. Epub 2017 May 18.

Pediatric Neurology, University of Louisville, Louisville, Kentucky. Electronic address:

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http://dx.doi.org/10.1016/j.pediatrneurol.2017.05.001DOI Listing
September 2017
1 Read

A rare association of ganglioglioma and cavernous malformation: Report of two cases and literature review.

Surg Neurol Int 2017 26;8:94. Epub 2017 May 26.

Department of Medicine, Surgery, and Neurosciences, Section of Neurosurgery, University of Siena, Siena, Italy.

Background: Some glial tumors have been observed in association with different types of vascular malformations of the brain (angiogliomas). However, the association of ganglioglioma with other vascular malformations is extremely rare, with only few cases reported in the literature, one of which is referred to as "angioganglioglioma."

Case Description: Two patients presented with acute onset of neurological symptoms, with magnetic resonance imaging (MRI) finding of cavernoma of the left middle cerebellar penduncle, and small mass of the chiasmatic region, respectively. Read More

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http://dx.doi.org/10.4103/2152-7806.207115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5461571PMC
May 2017
2 Reads

Surgery for dysembryoplastic neuroepithelial tumors and gangliogliomas in eloquent areas. Functional results and seizure control.

Neurochirurgie 2017 Jun 12;63(3):227-234. Epub 2017 May 12.

Service d'anatomie pathologique, hôpital Sainte-Anne, université Paris Descartes, 75014 Paris, France.

Introduction: Dysembryoplastic neuroepithelial tumors and gangliogliomas are developmental glioneuronal tumors usually revealed by partial epilepsy. High epileptogenicity, childhood epilepsy onset, drug-resistance, temporal location, and seizure freedom after complete resection are common characteristics of both tumors. We report the specificity of surgical management, functional results and seizure outcome in cases of a tumor location in eloquent areas. Read More

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http://dx.doi.org/10.1016/j.neuchi.2016.10.009DOI Listing
June 2017
19 Reads

Natural course and prognosis of anaplastic gangliogliomas: a multicenter retrospective study of 43 cases from the French Brain Tumor Database.

Neuro Oncol 2017 05;19(5):678-688

CHRU de Tours, Service de Neurochirurgie, Tours, France.

Background: Anaplastic gangliogliomas (GGGs) are rare tumors whose natural history is poorly documented. We aimed to define their clinical and imaging features and to identify prognostic factors.

Methods: Consecutive cases of anaplastic GGGs in adults prospectively entered into the French Brain Tumor Database between March 2004 and April 2014 were screened. Read More

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http://dx.doi.org/10.1093/neuonc/now186DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5464461PMC
May 2017
32 Reads

Pediatric Basal Ganglia Region Tumors: Clinical and Radiologic Features Correlated with Histopathologic Findings.

World Neurosurg 2017 Jul 10;103:504-516. Epub 2017 Apr 10.

Department of Neurosurgery, West China Hospital of Sichuan University, Chengdu, Sichuan, China. Electronic address:

Purpose: To summarize the clinical and radiologic features of pediatric basal ganglia region tumors (PBGRT) in correlation with their histopathologic findings to reduce inappropriate surgery and identify tumors that can benefit from maximal safe resection.

Methods: The records of 35 children with PBGRT treated in our hospital from December 2011 to December 2015 were analyzed retrospectively. The clinical and radiologic features of these tumors were summarized and correlated with their histopathologic diagnosis. Read More

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http://dx.doi.org/10.1016/j.wneu.2017.04.004DOI Listing
July 2017
6 Reads

Intraventricular ganglioglioma with extensive hemorrhage.

Clin Neuropathol 2017 Jul/Aug;36(4):178-182

Gangliogliomas represent a rare form of neuroepithelial tumor (up to 1.3% of brain tumors [1]), which even more rarely present with hemorrhage or localize intraventricularly. To date, only two cases of ganglioglioma with both of these features have been reported. Read More

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http://dx.doi.org/10.5414/NP301007DOI Listing
August 2018
4 Reads

5ALA in pediatric brain tumors is not routinely beneficial.

Childs Nerv Syst 2017 May 14;33(5):787-792. Epub 2017 Mar 14.

Department of Pediatric Neurosurgery, Dana Children's Hospital, Tel Aviv Medical Center, Tel Aviv University, 6 Weizman Street, 64239, Tel Aviv, Israel.

Purpose: Over recent years, 5-aminoluvolinic acid (5ALA) has been increasingly used for resection guidance in adult high-grade gliomas. However, amongst pediatric patients, publication of intraoperative fluorescence has been limited, with inconsistent outcomes. We describe our experience and intraoperative finding amongst children with various brain tumors that were given 5ALA prior to tumor resection. Read More

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http://dx.doi.org/10.1007/s00381-017-3371-8DOI Listing
May 2017
6 Reads