219 results match your criteria Imaging in Embryonic Demise


Evidence for uteroplacental malperfusion in fetuses with major congenital heart defects.

PLoS One 2020 5;15(2):e0226741. Epub 2020 Feb 5.

Fetal Medicine Unit, St George's University Hospitals NHS Foundation Trust and Molecular & Clinical Sciences Research Institute, St George's University of London, London, England, United Kingdom.

Aims: Fetuses affected by congenital heart defects (CHD) are considered to be at increased risk of fetal growth restriction and intrauterine demise. Whether these risks are a direct consequence of fetal CHD or a result of associated uteroplacental dysfunction is not evident from the data of recent studies. The aim of this study was to investigate the prevalence of uteroplacental dysfunction reflected by abnormal uterine artery Doppler indices and reduced fetal growth in CHD pregnancies. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0226741PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7001956PMC

Pseudolesion in the right parafissural liver parenchyma on CT: The base is found in embryology and collagen content.

PLoS One 2020 27;15(1):e0221544. Epub 2020 Jan 27.

Department of Forensic Medicine and Imaging, Institute of Forensic Medicine, University of Zürich, Zürich, Switzerland.

Background: Computed tomography (CT) images of livers may show a hypo-attenuated structure alongside the falciform ligament, which can be a focal fatty pseudolesion and can mimic a malignancy. The preferred location is on the right parafissural site, ventral in segment IVa/b. The etiology is not clear, nor is it known how the histology of this location develops. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0221544PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6984698PMC

Neglected intrauterine fetal demise for more than two decades leading to the development of a lithopedion: a case report.

J Med Case Rep 2019 Nov 12;13(1):330. Epub 2019 Nov 12.

Department of Radiology, Addis Ababa University, College of Health Sciences, Addis Ababa, Ethiopia.

Background: Lithopedion is a word derived from the Greek words lithos, meaning stone, and paidion, meaning child, to describe a fetus that has become stony or petrified. Lithopedion is a rare complication of pregnancy which occurs when a fetus dies and becomes too large to be reabsorbed by the body. This entity in rare circumstances can be challenging for physicians to diagnose since it has a range of clinical manifestations. Read More

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http://dx.doi.org/10.1186/s13256-019-2264-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6849196PMC
November 2019

Diagnosis and Management of Placental Mesenchymal Disease. A Review of the Literature.

Obstet Gynecol Surv 2019 Oct;74(10):611-622

Professor, Department of Obstetrics and Gynecology, University of Arkansas for the Medical Sciences, Little Rock, AR.

Objective: To review what is currently known about placental mesenchymal dysplasia (PMD) including imaging techniques for diagnosis and differentiation from a molar pregnancy, genetics, maternal/fetal effects, and management.

Evidence Acquisition: A literature search by research librarians at 2 universities was undertaken using the search engines PubMed and Web of Science. The search terms used were "etiology" OR "cause" OR "risk" OR "risks" OR "epidemiology" OR "diagnosis" OR "therapy" OR "prognosis" OR "management" AND "placental mesenchymal dysplasia" OR "placenta" AND "mesenchymal dysplasia. Read More

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http://dx.doi.org/10.1097/OGX.0000000000000716DOI Listing
October 2019
1 Read

Progesterone's Serum Level and a New Ultrasonographic Parameter in the First Trimester Pregnancy - Prognostic Factors for Embryonic Demise.

Rev Bras Ginecol Obstet 2019 Sep 23;41(9):525-530. Epub 2019 Sep 23.

Department of Obstetrics and Gynecology, University of Medicine and Pharmacy "Iuliu Haţieganu", Cluj-Napoca, Romania.

Objective:  The etiology of embryonic demise is multifactorial, with chromosomal abnormalities being the most common (40%). The purpose of the present study is to evaluate the correlation between a serum biomarker, progesterone, and an ultrasonographic parameter, the distance between yolk sac and embryo (DYSE) in assessing the prognosis of pregnancy outcome in the 1 trimester.

Methods:  The present study is a prospective case-control analysis that includes 2 groups of patients: 81 patients with first-trimester normal evolutive pregnancy and 89 patients with embryonic demise, all of the patients having between 6 and 11 weeks of amenorrhea. Read More

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http://dx.doi.org/10.1055/s-0039-1696948DOI Listing
September 2019

Re-evaluating the role of cerebroplacental ratio in predicting adverse perinatal outcome.

Eur J Obstet Gynecol Reprod Biol 2019 Nov 8;242:17-28. Epub 2019 Aug 8.

Perinatal Ultrasound Department, Nepean Hospital, Australia; Nepean Clinical School, The University of Sydney, Australia.

Aim: This meta-analysis evaluates the use of cerebroplacental ratio (CPR) in predicting adverse perinatal outcome.

Methods: An electronic search of PubMed, Embase, Google scholar, Cochrane Library and Up-to-Date was done using variations of 'cerebroplacental ratio' and 'cerebroumbilical ratio'. We included studies where CPR was measured and postpartum outcomes were available. Read More

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http://dx.doi.org/10.1016/j.ejogrb.2019.06.033DOI Listing
November 2019

Volume and vascularity: Using ultrasound to unlock the secrets of the first trimester placenta.

Placenta 2019 09 26;84:32-36. Epub 2019 Jun 26.

Nuffield Department of Women's and Reproductive Health, University of Oxford, UK; Fetal Medicine Unit, The Women's Centre, John Radcliffe Hospital, Oxford, UK. Electronic address:

Fetal growth restriction (FGR) is a major cause of perinatal morbidity and mortality. Identifying which pregnancies are at risk of FGR facilitates enhanced surveillance and early delivery before fetal demise can ensue. However, existing risk stratification strategies yield an unacceptably low detection rate. Read More

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http://dx.doi.org/10.1016/j.placenta.2019.06.379DOI Listing
September 2019
4 Reads

Ethical Considerations in Multiple Pregnancy: Preterm Delivery in the Setting of Discordant Fetal Anomaly.

Twin Res Hum Genet 2019 04 26;22(2):120-123. Epub 2019 Apr 26.

Multiple Pregnancy Clinic,The Royal Women's Hospital,Melbourne, Victoria,Australia.

Planning for the preterm birth of a fetus with known anomalies can raise complex ethical issues. This is particularly true of multiple pregnancies, where the interests of each fetus and of the expectant parent(s) can conflict. In these complex situations, parental wishes and values can also conflict with the recommendations of treating clinicians. Read More

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http://dx.doi.org/10.1017/thg.2019.12DOI Listing
April 2019
6 Reads

Fetal and perinatal outcome associated with small cerebellar diameter based on second- or third-trimester ultrasonography.

Prenat Diagn 2019 06 29;39(7):536-543. Epub 2019 May 29.

Hospices Civils de Lyon, Department of Obstetrics and Gynecology, Hôpital Femme Mère Enfant, Université Claude Bernard, Lyon 1, Bron-, Lyon, 69500, France.

Objective: To examine the outcome of pregnancy with fetal transverse cerebellar diameter (TCD) below the fifth percentile based on routine second- or third-trimester ultrasonography.

Methods: We retrospectively analyzed the outcomes of 12 344 women according to TCD Z scores based on systematic second- or third-trimester ultrasound examination between 2007 and 2015. Information on major malformations, chromosomal anomalies, intrauterine or neonatal demise, and other abnormal findings were collected. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/pd.5465
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http://dx.doi.org/10.1002/pd.5465DOI Listing
June 2019
25 Reads

Primary fetal pleural effusion: Characteristics, outcomes, and the role of intervention.

Prenat Diagn 2019 05 9;39(6):484-488. Epub 2019 May 9.

Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, Baylor College of Medicine and Texas Children's Hospital, Houston, TX.

Background: We aimed to present the natural history and outcomes of fetal primary pleural effusions (PPE).

Methods: Fetuses with prenatal diagnosis of PPE delivered between January 2011 and June 2018 were included. Fetal PPE were separated into groups: resolved, stable, or progressive. Read More

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http://dx.doi.org/10.1002/pd.5462DOI Listing
May 2019
8 Reads
2.514 Impact Factor

Fetal cardiac findings and hemodynamic changes associated with severe lower urinary tract obstruction in utero.

Ultrasound Obstet Gynecol 2019 Dec 4;54(6):780-785. Epub 2019 Nov 4.

Department of Pediatrics, Division of Pediatric Cardiology, Columbia University Medical Center, New York-Presbyterian Hospital, New York, NY, USA.

Objectives: To describe fetal echocardiographic findings associated with lower urinary tract obstruction (LUTO) and to compare anatomic and hemodynamic measurements between fetuses with LUTO and gestational age (GA)-matched controls, with an emphasis on quantitative indices of diastolic function and cardiac output.

Methods: This was a retrospective cohort study of fetuses diagnosed with severe LUTO with giant bladder, which underwent at least one fetal echocardiogram at our center between January 2005 and June 2018. Fetuses with major congenital heart disease were excluded. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/uog.20271
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http://dx.doi.org/10.1002/uog.20271DOI Listing
December 2019
17 Reads

Yolk sac-embryo distance in correlation with soluble form of vascular endothelial growth factor levels in pregnancy with potentially reserved evolutivity.

Med Ultrason 2018 Dec;20(4):487-492

II ND Department of Obstetrics and Gynaecology , University of Medicine and Pharmacy Iuliu Hatieganu, Cluj Napoca, Romania.

Aims: Embryonic demise is a frequent complication of the first trimester pregnancy. The purpose of this study was to evaluate the correlation between a serum biomarker, the soluble form of the vasculo-endothelial growth factor (sFlt-1) and the distance between the yolk sac (YS) and embryo (DYSE), determined by ultrasonography.

Material And Methods: The study was a prospective case-control study that included 2 groups of patients - the control group with 81 first-trimester pregnancies in evolution and the case group with 89 first-trimester pregnancies with a potentially reserved evolutivity. Read More

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http://dx.doi.org/10.11152/mu-1504DOI Listing
December 2018
11 Reads

Persistent amnion-chorion membrane separation.

J Obstet Gynaecol Res 2019 Feb 8;45(2):352-357. Epub 2018 Nov 8.

Department of Obstetrics and Gynecology, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA.

Aim: Fetal membranes are composed of the amnion and chorion, which fuse during the early second trimester. Persistent separation confers increased risk of adverse perinatal outcomes. This study characterizes sonographic and placental findings associated with persistent amnion-chorion (AC) membrane separation. Read More

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http://doi.wiley.com/10.1111/jog.13852
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http://dx.doi.org/10.1111/jog.13852DOI Listing
February 2019
36 Reads

Intertwin membrane separation in dichorionic twin pregnancy associated with intrauterine co-twin demise.

Authors:
Shunji Suzuki

Int J Gynaecol Obstet 2018 11 16;143(2):246-247. Epub 2018 Aug 16.

Department of Obstetrics and Gynecology, Japanese Red Cross Katsushika Maternity Hospital, Tokyo, Japan.

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http://dx.doi.org/10.1002/ijgo.12639DOI Listing
November 2018
6 Reads

Factors associated to early intrauterine fetal demise after laser for TTTS by preoperative fetal heart and Doppler ultrasound.

Prenat Diagn 2018 06 6;38(7):523-530. Epub 2018 Jun 6.

Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, CHU Sainte-Justine, Montreal University, Montreal, Québec, Canada.

Objective: To determine the prognostic value of fetal Doppler and echocardiographic parameters for intrauterine fetal demise (IUFD) within 24 hours and within 1 week after laser coagulation in monochorionic pregnancies complicated by twin-twin transfusion syndrome.

Method: This retrospective study correlated the preoperative hemodynamic and echocardiography parameters to the outcome in fetuses with twin-twin transfusion syndrome undergoing laser therapy.

Results: One hundred and twelve laser coagulations were performed between February 2006 and June 2015. Read More

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http://dx.doi.org/10.1002/pd.5280DOI Listing
June 2018
55 Reads

Prediction of adverse pregnancy outcome in monochorionic diamniotic twin pregnancy complicated by selective fetal growth restriction.

Ultrasound Obstet Gynecol 2019 02;53(2):200-207

Fetal Medicine Unit, St George's University Hospitals NHS Foundation Trust, University of London, London, UK.

Objective: To identify key factors associated with adverse perinatal outcome in monochorionic diamniotic twin pregnancy complicated by selective fetal growth restriction (sFGR).

Methods: This was a retrospective cohort study of all monochorionic diamniotic twin pregnancies diagnosed with sFGR at ≥ 16 weeks' gestation, in a single tertiary referral center between March 2000 and May 2015. The presence of coexisting twin-twin transfusion syndrome (TTTS) was noted. Read More

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http://dx.doi.org/10.1002/uog.19078DOI Listing
February 2019
25 Reads

Neural Tube Defects in Embryonic Life: Lessons Learned From 340 Early Pregnancy Failures.

J Ultrasound Med 2018 Dec 17;37(12):2841-2847. Epub 2018 Apr 17.

Division of Prenatal Medicine, Department of Obstetrics and Gynecology, University of Schleswig-Holstein, Luebeck, Germany.

Objectives: The aim of this study was to evaluate the feasibility of sonographic assessment of the embryonic/fetal neural tube in nonviable pregnancies and to determine the defect incidence.

Methods: Prospective analysis of transvaginally acquired 3-dimensional (3D) multiplanar and 3D surface-rendered volume sets of 340 cases of missed abortion between March 2010 and September 2015 was performed. Data regarding karyotype and postmortem examination as well as demographic features and the outcomes of subsequent pregnancies were evaluated. Read More

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http://dx.doi.org/10.1002/jum.14642DOI Listing
December 2018
14 Reads

Subchorionic Hematoma: Correlation of Grading Techniques With First-Trimester Pregnancy Outcome.

J Ultrasound Med 2018 Jul 17;37(7):1725-1732. Epub 2018 Jan 17.

Departments of Radiology, Obstetrics and Gynecology , Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.

Objectives: To evaluate and compare grading systems of subchorionic hematoma (SCH) on first-trimester ultrasound examinations with live embryos to assess which best correlates with early pregnancy outcome and to assess the effect of gestational age at the time of diagnosis on outcome.

Methods: First-trimester live singleton pregnancies between 6 and 11 weeks' gestational age with SCH were identified by an institutional database search. First-trimester outcome was categorized as "live" or "demise" based on ultrasound or medical record documentation. Read More

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http://doi.wiley.com/10.1002/jum.14524
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http://dx.doi.org/10.1002/jum.14524DOI Listing
July 2018
37 Reads

Cardiac function and dysfunction in the fetus.

Echocardiography 2017 12;34(12):1776-1787

Fetal & Neonatal Cardiology Program, Echocardiography Laboratory, Division of Cardiology, Departments of Pediatrics, Women & Children's Health Research, Mazankowski Alberta Heart Institutes, and Cardiovascular Research Centre, University of Alberta, Edmonton, AB, Canada.

Evaluation of fetal cardiac function is one of the most important components of fetal echocardiography. Fetal cardiac dysfunction is closely linked to risk of intrauterine fetal demise, in many, but not all cases is indicative of worse postnatal prognosis and may prompt the use of medications or interventions to optimize outcomes. There may be implications for termination versus continuation of pregnancy, an indication for early delivery, a change in location and even mode of delivery. Read More

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http://doi.wiley.com/10.1111/echo.13654
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http://dx.doi.org/10.1111/echo.13654DOI Listing
December 2017
13 Reads

Fetal brain sparing in a mouse model of chronic maternal hypoxia.

J Cereb Blood Flow Metab 2019 06 22;39(6):1172-1184. Epub 2017 Dec 22.

1 Mouse Imaging Centre, The Hospital for Sick Children, Toronto, Ontario, Canada.

Hypoxic stress is a common occurrence during human pregnancy, yet little is known about its effects on the fetal brain. This study examined the fetal hemodynamic responses to chronic hypoxia in an experimental mouse model of chronic maternal hypoxia (11% O from E14.5 to E17. Read More

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http://dx.doi.org/10.1177/0271678X17750324DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6547196PMC
June 2019
36 Reads

Risk of donor demise after laser therapy for twin-twin transfusion when complicated by growth discordance and abnormal umbilical artery Doppler findings.

J Matern Fetal Neonatal Med 2019 Apr 27;32(8):1332-1336. Epub 2017 Nov 27.

a Department of Obstetrics and Gynecology , Charlotte Fetal Care Center , Charlotte , NC , USA.

Objective: To investigate the natural course of abnormal umbilical artery Doppler (UAD) findings in donor fetuses after laser surgery and the prognostic significance of resolution, persistence, or new onset UAD abnormalities with and without the presence of preoperative growth discordance.

Study Design: Retrospective cohort study of all monochorionic-diamniotic multi-fetal gestations diagnosed with twin-twin transfusion syndrome (TTTS) undergoing laser surgery at a single large metropolitan referral center from 2010-2016. The estimated fetal weight was measured preoperatively and the UAD were measured both pre- and postoperatively (median = 8 days). Read More

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http://dx.doi.org/10.1080/14767058.2017.1404983DOI Listing
April 2019
14 Reads

Non-Immune Hydrops Fetalis: Do Placentomegaly and Polyhydramnios Matter?

J Ultrasound Med 2018 May 27;37(5):1185-1191. Epub 2017 Oct 27.

Department of Obstetrics, Gynecology, and Reproductive Sciences, Division of Maternal-Fetal Medicine, University of California, San Francisco, California, USA.

Objectives: Polyhydramnios and placentomegaly are commonly observed in nonimmune hydrops fetalis (NIHF); however, whether their ultrasonographic identification is relevant for prognosis is controversial. We evaluated outcomes of fetal or neonatal death and preterm birth (PTB) in cases of NIHF alone and in those with polyhydramnios and/or placentomegaly (P/PM).

Methods: We conducted a retrospective cohort of singletons with NIHF evaluated between 1994 and 2013. Read More

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http://dx.doi.org/10.1002/jum.14462DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6029704PMC
May 2018
25 Reads

Fetal intra-abdominal umbilical vein varix: retrospective cohort study and systematic review and meta-analysis.

Ultrasound Obstet Gynecol 2018 May;51(5):580-585

Maternité Hôpital Necker-Enfants Malades, Assistance Publique, Hôpitaux de Paris, Université Paris Descartes, Paris, France.

Objective: To investigate the ultrasound characteristics and outcome of pregnancies with fetal intra-abdominal umbilical vein varix (FIUVV).

Methods: Cases of FIUVV managed at our tertiary university hospital over an 8-year period were reviewed. Information retrieved included gestational age and diameter of the umbilical varix at diagnosis, increase in varix diameter, associated ultrasound or chromosomal anomalies and pregnancy outcome. Read More

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http://dx.doi.org/10.1002/uog.18895DOI Listing
May 2018
36 Reads

Excessive Maternal Orange Intake - A Reversible Etiology of Fetal Premature Ductus Arteriosus Constriction: A Case Report.

Authors:
Shaimaa Rakha

Fetal Diagn Ther 2017 27;42(2):158-160. Epub 2017 Jul 27.

Pediatric Cardiology Unit, Mansoura University Children Hospital, Mansoura University, Mansoura, Egypt.

Ductus arteriosus (DA) is a crucial element in the fetal circulation. Therefore, premature constriction of DA during the third trimester can have hazardous complications such as right ventricular dysfunction, fetal heart failure, hydrops, and even in utero demise. Normally, premature constriction is prevented by a balance between prostaglandin E2 and fetal oxygenation. Read More

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http://dx.doi.org/10.1159/000453063DOI Listing
May 2018
19 Reads

The Vanishing Twin Syndrome: Two Cases of Extreme Malformations Associated With Vanished Twins.

Pediatr Dev Pathol 2017 Jul-Aug;20(4):348-353. Epub 2017 Jan 25.

2 Division of Anatomic Pathology, Department of Pathology, Emory University School of Medicine, Children's Healthcare of Atlanta, Atlanta, Georgia, USA.

Two cases of devastating fetal malformations associated with vanished monochorionic twins were identified upon review of pathology files. A 35-year-old G1P0 woman and 36-year-old G3P1 woman were both diagnosed with an intrauterine twin gestation via transvaginal ultrasound at 10 weeks. The spectrum of fetal anomalies ranged from omphalocele, bilateral upper extremity, and unilateral lower extremity hypoplasia, to craniofacial malformation with diaphragmatic hernia. Read More

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http://dx.doi.org/10.1177/1093526616686470DOI Listing
May 2019
33 Reads
0.860 Impact Factor

Whole-exome sequencing on deceased fetuses with ultrasound anomalies: expanding our knowledge of genetic disease during fetal development.

Genet Med 2017 10 20;19(10):1171-1178. Epub 2017 Apr 20.

GeneDx, Gaithersburg, Maryland, USA.

PurposeThe aim of this study was to determine the diagnostic yield of whole-exome sequencing (WES) in fetuses with ultrasound anomalies that resulted in fetal demise or pregnancy termination. The results were also utilized to aid in the identification of candidate genes for fetal development and to expand the clinical phenotype of known genetic conditions.MethodsWES was performed on specimens from 84 deceased fetuses. Read More

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http://dx.doi.org/10.1038/gim.2017.31DOI Listing
October 2017
29 Reads

Zika Virus Infection Associated With Congenital Birth Defects in a HIV-infected Pregnant Woman.

Pediatr Infect Dis J 2017 May;36(5):500-501

From the *Infectious Diseases Department, Hospital Federal dos Servidores do Estado, Rio de Janeiro, Brazil; †Instituto Nacional de Infectologia Evandro Chagas - Fiocruz, Rio de Janeiro, Brazil; and ‡Hospital Maternidade Maria Amelia Buarque de Hollanda, Rio de Janeiro, Brazil.

We describe a case of Zika virus infection acquired during the first trimester in a HIV-infected pregnant woman that led to multiple fetal malformations and fetal demise in Rio de Janeiro, Brazil. Read More

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http://dx.doi.org/10.1097/INF.0000000000001482DOI Listing
May 2017
107 Reads

Conventional vs virtual autopsy with postmortem MRI in phenotypic characterization of stillbirths and fetal malformations.

Ultrasound Obstet Gynecol 2018 02;51(2):236-245

Department of Pediatrics, All India Institute of Medical Sciences, New Delhi, India.

Objective: To compare virtual autopsy using postmortem magnetic resonance imaging (MRI) with conventional autopsy with respect to phenotypic characterization of stillbirths and malformed fetuses, and acceptability to parents.

Methods: This was a prospective diagnostic evaluation study, conducted from June 2013 to June 2015, including stillbirths and pregnancies terminated owing to fetal malformation at ≥ 20 weeks' gestation, for which parental consent to both conventional autopsy and postmortem MRI was obtained. Cases of maternal and obstetric cause of fetal demise were excluded. Read More

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http://dx.doi.org/10.1002/uog.17468DOI Listing
February 2018
16 Reads

Influence of chorionicity and gestational age at single fetal loss on risk of preterm birth in twin pregnancy: analysis of STORK multiple pregnancy cohort.

Ultrasound Obstet Gynecol 2017 Dec;50(6):723-727

Fetal Medicine Unit, Division of Developmental Sciences, St George's University of London, London, UK.

Objective: Single intrauterine death (sIUD) in twin pregnancy is associated with a significant risk of cotwin demise and preterm birth (PTB), especially in monochorionic (MC) twins. However, it is yet to be established whether the gestational age at loss may influence the pregnancy outcome. The aim of this study was to explore the risk of PTB according to the gestational age at diagnosis of sIUD. Read More

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http://doi.wiley.com/10.1002/uog.17426
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http://dx.doi.org/10.1002/uog.17426DOI Listing
December 2017
3 Reads

Does First-Trimester Screening Modify the Natural History of Congenital Heart Disease? Analysis of Outcome of Regional Cardiac Screening at 2 Different Time Periods.

Circulation 2017 Mar 31;135(11):1045-1055. Epub 2017 Jan 31.

From Department of Pediatric Cardiology, University Hospital Brno and Faculty of Medicine, Masaryk University, Czech Republic (H.J.); Fetal Medicine Center, Brno, Czech Republic (H.J., P.V., I.G.); Children's Heart Center, 2nd Faculty of Medicine, Charles University and Motol University Hospital, Prague, Czech Republic (M.J., V.T., J.S., J.M.); University Hospital Sv. Anny, Brno, Czech Republic (I.G.); Louisiana State University Health-New Orleans, School of Public Health (J.V.); and Great Ormond Street Hospital for Children and Institute of Cardiovascular Sciences UCL, London, UK (J.M.).

Background: The study analyzed the impact of first-trimester screening on the spectrum of congenital heart defects (CHDs) later in pregnancy and on the outcome of fetuses and children born alive with a CHD.

Methods: The spectrum of CHDs, associated comorbidities, and outcome of fetuses, either diagnosed with a CHD in the first trimester (Group I, 127 fetuses) or only in the second-trimester screening (Group II, 344 fetuses), were analyzed retrospectively between 2007 and 2013. Second-trimester fetuses diagnosed with a CHD between 2007 and 2013 were also compared with Group III (532 fetuses diagnosed with a CHD in the second trimester from 1996 to 2001, the period before first-trimester screening was introduced). Read More

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https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.115.0
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http://dx.doi.org/10.1161/CIRCULATIONAHA.115.020864DOI Listing
March 2017
27 Reads

Are early pregnancy complications more common in women with hyperemesis gravidarum?

J Obstet Gynaecol 2017 Apr 31;37(3):355-357. Epub 2017 Jan 31.

a Early Pregnancy and Acute Gynaecology Assessment Unit , King's College Hospital , London , UK.

Ultrasound evaluation is usually requested for women presenting with hyperemesis gravidarum (HG) in early pregnancy. This is to check viability as well as to diagnose multiple pregnancies and exclude gestational trophoblastic disease (GTD). The aim of this retrospective case control study was to evaluate the early pregnancy outcomes in women with HG and to compare them with an asymptomatic control group. Read More

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http://dx.doi.org/10.1080/01443615.2016.1256955DOI Listing
April 2017
28 Reads

The Fetus with Ectopia Cordis: Experience and Expectations from Two Centers.

Pediatr Cardiol 2017 Mar 19;38(3):531-538. Epub 2016 Dec 19.

Fetal Treatment Center, University of California, San Francisco Benoiff Children's Hospital, San Francisco, CA, USA.

Ectopia cordis (EC) is a rare congenital anomaly often associated with congenital heart disease (CHD). There is a lack of contemporary information on EC diagnosed prenatally. We sought to combine the experiences of two regional referral centers in order to evaluate current outcomes for EC. Read More

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http://dx.doi.org/10.1007/s00246-016-1545-xDOI Listing
March 2017
34 Reads

A case of rudimentary horn pregnancy diagnosed after failed attempts at pregnancy termination.

Niger J Clin Pract 2017 Jan;20(1):111-114

Department of Obstetrics and Gynecology, Kanuni Sultan Suleyman Training and Research Hospital, Istanbul, Turkey.

We report a case of rudimentary horn pregnancy at 12 weeks gestation with fetal demise misdiagnosed ultrasonographically as an intrauterine pregnancy in a private clinic. The patient was referred to a tertiary care hospital after failed attempts at terminating her pregnancy. A definitive diagnosis was made with ultrasonography and magnetic resonance imaging (MRI) before uterine rupture ensued. Read More

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http://dx.doi.org/10.4103/1119-3077.187317DOI Listing
January 2017
13 Reads

Neonatal Outcomes in Fetuses With a Persistent Intrahepatic Right Umbilical Vein.

J Ultrasound Med 2016 Oct 31;35(10):2237-41. Epub 2016 Aug 31.

Department of Obstetrics, Gynecology, and Reproductive Sciences, Division of Ultrasound, Magee-Womens Hospital, University of Pittsburgh, Pittsburgh, Pennsylvania USA.

Objectives: A fetal persistent intrahepatic right umbilical vein has been linked to anomalies and genetic disorders but can be a normal variant. We conducted a retrospective review to determine other sonographic findings that can stratify fetuses for further evaluation.

Methods: A total of 313 fetuses had a persistent intrahepatic right umbilical vein identified on 17- to 24-week sonography. Read More

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http://dx.doi.org/10.7863/ultra.15.10015DOI Listing
October 2016
13 Reads

Echocardiographic Parameters and Outcomes in Primary Fetal Cardiomyopathy.

J Ultrasound Med 2016 Sep 27;35(9):1949-55. Epub 2016 Jul 27.

Section of Pediatric Cardiology, Texas Children's Hospital, Baylor College of Medicine, Houston, Texas USA.

Objectives: Primary fetal cardiomyopathy is a rare entity, with a poor prognosis. We sought to describe its echocardiographic characteristics and outcomes.

Methods: We performed a 12-year retrospective review of fetuses with primary cardiomyopathy. Read More

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http://dx.doi.org/10.7863/ultra.15.05059DOI Listing
September 2016
20 Reads

Cardiac Findings in the Fetus with Cerebral Arteriovenous Malformation Are Associated with Adverse Outcome.

Fetal Diagn Ther 2017 3;41(2):108-114. Epub 2016 Jun 3.

Department of Cardiology, Children's Hospital Boston, Boston Mass., USA.

Objectives: To assess cardiac sequelae of fetal cerebral arteriovenous malformations (CAVMs) and evaluate any association with outcomes.

Methods: We retrospectively analyzed cardiac structure and function in fetuses with CAVMs who underwent fetal echocardiography (October 1999 to August 2015, n = 11), and compared them with normal controls.

Results: The median gestational age was 36 weeks (range 18-38). Read More

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https://www.karger.com/Article/FullText/446432
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http://dx.doi.org/10.1159/000446432DOI Listing
August 2017
10 Reads

Ebstein's Anomaly of the Tricuspid Valve in the Fetus - A Multicenter Experience.

Ultraschall Med 2017 Aug 1;38(4):427-436. Epub 2016 Jun 1.

Division of Prenatal Medicine and Gynecologic Sonography, Department of Obstetrics and Gynecology, University of Köln, Germany.

 To assess the spectrum of associated anomalies, the intrauterine course, the outcome and possible prognostic markers in prenatally diagnosed Ebstein's anomaly (EA).  All cases of EA diagnosed over a period of 13 years with a minimum follow-up of 1 year were retrospectively collected in 4 tertiary referral centers in Germany.  In the study period 76 cases of EA were prenatally diagnosed. Read More

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http://dx.doi.org/10.1055/s-0042-107151DOI Listing
August 2017
22 Reads

[Ultrasound Examination and Management of Twin Pregnancy.]

Akush Ginekol (Sofiia) 2016;55(6):19-25

Twin pregnancies are found in about 3 % of all pregnancies and 2/3 are dizygotic and 1/3 are monozygotic. In the last 30 years after the introduction of assisted conception and increasing maternal age the rate of twin pregnancies dramatically increased. Compared to singletons, twins have more complications such as intrauterine demise, intrauterine selective fetal growth reStriction, congenital anomalies, miscarriage and preterm labour. Read More

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May 2018
3 Reads

Umbilical Artery Half-Peak Systolic Velocity Deceleration Time in Fetal Growth Restriction.

Fetal Diagn Ther 2016 23;40(2):128-34. Epub 2015 Dec 23.

Department of Obstetrics and Gynecology, San Juan de Dios Hospital, School of Medicine, University of Chile, Clinica Santa Maria, Santiago, Chile.

Objective: To study the umbilical artery (UA) half-peak systolic velocity deceleration time (hPSV-DT) in pregnancies complicated by fetal growth restriction (FGR).

Methods: The study included 266 singleton, high-risk pregnancies with an estimated fetal weight <10th percentile, which were examined between 24 and 40 weeks' gestation and delivered within a week from the last ultrasound evaluation. UA hPSV-DT was measured with Doppler ultrasound in the same wave used to measure the pulsatility index. Read More

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http://dx.doi.org/10.1159/000442049DOI Listing
February 2017
6 Reads

Consequences of zygote injection and germline transfer of mutant human mitochondrial DNA in mice.

Proc Natl Acad Sci U S A 2015 Oct 5;112(42):E5689-98. Epub 2015 Oct 5.

Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami FL 33136;

Considerable evidence supports mutations in mitochondrial genes as the cause of maternally inherited diseases affecting tissues that rely primarily on oxidative energy metabolism, usually the nervous system, the heart, and skeletal muscles. Mitochondrial diseases are diverse, and animal models currently are limited. Here we introduced a mutant human mitochondrial gene responsible for Leber hereditary optic neuropathy (LHON) into the mouse germ line using fluorescence imaging for tissue-specific enrichment in the target retinal ganglion cells. Read More

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http://dx.doi.org/10.1073/pnas.1506129112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4620890PMC
October 2015
68 Reads

Presumed monozygotic twins develop following transfer of an in vitro-produced equine embryo.

J Equine Sci 2015 30;26(3):89-94. Epub 2015 Sep 30.

Department of Dairy Science, California Polytechnic State University, CA 93407, U.S.A.

An equine embryo produced by intracytoplasmic sperm injection (ICSI) was trans-cervically transferred to a recipient mare and pregnancy was confirmed via ultrasound examination on days 11, 12 and 15. On days 20 and 22, a single embryonic proper with a heartbeat was observed. On day 29, two embryos proper appeared during ultrasound examination, each possessing a heartbeat. Read More

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http://dx.doi.org/10.1294/jes.26.89DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4591415PMC
October 2015
5 Reads

Echogenic intracardiac focus on second trimester ultrasound: prevalence and significance in a Middle Eastern population.

J Matern Fetal Neonatal Med 2016 15;29(14):2293-6. Epub 2015 Sep 15.

a Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology , American University of Beirut Medical Center , Beirut , Lebanon .

Objective: The association between echogenic intracardiac focus (EIF) and trisomy 21 is well established, with a recognized ethnic variation. Our study aimed to determine the prevalence of EIF in a Middle Eastern population and to examine its association with trisomy 21 and other adverse pregnancy outcomes.

Methods: Retrospective case-control study of second-trimester obstetric sonograms (16-28 weeks) performed at a tertiary care center over a 5-year period. Read More

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http://dx.doi.org/10.3109/14767058.2015.1083549DOI Listing
January 2017
29 Reads

Aplasia Cutis Congenita Associated with Fetus Papyraceus.

Pediatr Dermatol 2015 Nov-Dec;32(6):858-61. Epub 2015 Jul 27.

Department of Dermatology, Hospital del Niño Jesús, Madrid, Spain.

Aplasia cutis congenita (ACC), or congenital absence of skin, is a heterogeneous condition that may be due to varied mechanisms. ACC has rarely been reported in association with fetus papyraceus, representing a peculiar phenotype of ACC. We present six new cases of neonates born with symmetric ACC associated with intrauterine fetal demise of co-twins during the late first or early second trimester. Read More

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http://dx.doi.org/10.1111/pde.12651DOI Listing
September 2016
44 Reads

[Fetal cardiac interventions - are we ready for them?].

Ginekol Pol 2015 Apr;86(4):280-6

Objective: The aim of the study was to analyze types and methods of intrauterine fetal cardiac interventions performed between June 2011 and December 2013, and to assess the perinatal management of the neonates.

Methods: The program was developed after analysis of the available literature, practical individual training in Linz, Austria, and simulation of the procedure in a dissecting-room. The rules for anesthesia in pregnant women and their fetuses were developed. Read More

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http://dx.doi.org/10.17772/gp/2074DOI Listing
April 2015
9 Reads

Resolution of superimposed pre-eclampsia, and improvement in umbilical artery flow in a surviving twin after intrauterine demise of its co-twin.

J Obstet Gynaecol Res 2015 Sep 21;41(9):1473-7. Epub 2015 Jun 21.

Department of Obstetrics and Gynecology, Maimonides Medical Center.

Pre-eclampsia has a progressive clinical course, and is only cured by delivery of the placenta. We report a 30-year-old G1P0 with dichorionic twins, discordant growth and chronic hypertension who developed superimposed pre-eclampsia in her 21st week of gestation. After intrauterine demise of the severely growth-restricted twin, the superimposed pre-eclampsia resolved. Read More

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http://dx.doi.org/10.1111/jog.12725DOI Listing
September 2015
7 Reads

What you need to know when managing twins: 10 key facts.

Authors:
Lynn L Simpson

Obstet Gynecol Clin North Am 2015 Jun 9;42(2):225-39. Epub 2015 Mar 9.

Department of Obstetrics and Gynecology, Columbia University Medical Center, 622 West 168th Street, PH-16, New York, NY 10032, USA. Electronic address:

Twin pregnancies can be complicated. Early diagnosis with accurate dating, determination of chorionicity, screening for chromosomal and structural abnormalities, placental evaluation, and cervical length assessment should be completed in the first half of gestation. Routine fetal growth is recommended for all twins with serial surveillance for those complicated by anomalies, cervical shortening, growth disturbances, and amniotic fluid abnormalities. Read More

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http://dx.doi.org/10.1016/j.ogc.2015.01.002DOI Listing
June 2015
9 Reads

Abnormal umbilical artery Doppler findings in the recipient twin before laser surgery for twin-twin transfusion syndrome.

J Ultrasound Med 2015 May;34(5):843-6

Department of Obstetrics and Gynecology, Division of Maternal-Fetal Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California USA (S.P., L.M.K., A.L., R.H.C.); and Jackson Fetal Therapy Institute, Jackson Memorial Hospital, Miami, Florida USA (R.A.Q., E.V.K.)

Objectives: In twin-twin transfusion syndrome (TTTS), persistent absent or reversed end-diastolic flow in the umbilical artery is a rare finding in the recipient twin, and the clinical implications of this finding are not well characterized. We sought to study the clinical importance of abnormal umbilical artery Doppler waveforms in recipient twins and determine the perinatal survival of these twins after laser surgery.

Methods: A retrospective study of patients with TTTS treated with laser surgery between 2006 and 2012 was conducted. Read More

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http://dx.doi.org/10.7863/ultra.34.5.843DOI Listing
May 2015
11 Reads

Outcome of cesarean scar pregnancies diagnosed sonographically in the first trimester.

J Ultrasound Med 2015 Apr;34(4):595-9

Departments of Radiology (A.Y.M., C.B.B., D.A.C.) and Obstetrics and Gynecology (E.E.W., K.D.P., P.M.D.), Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts USA.

Objectives: The purpose of this study was to determine the outcome of cesarean scar pregnancies diagnosed during the first trimester.

Methods: We retrospectively identified all cesarean scar implantation pregnancies diagnosed by sonography before 14 weeks' gestation between 2000 and 2012 at our institution. We reviewed the patients' sonograms and medical records and recorded sonographic findings and pregnancy outcomes. Read More

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http://dx.doi.org/10.7863/ultra.34.4.595DOI Listing
April 2015
16 Reads

Discordance in fetal biometry and Doppler are independent predictors of the risk of perinatal loss in twin pregnancies.

Am J Obstet Gynecol 2015 Aug 28;213(2):222.e1-222.e10. Epub 2015 Feb 28.

Fetal Medicine Unit, St George's Hospital, St George's University of London, London, England, UK.

Objective: Impaired fetal growth might be better evaluated in twin pregnancies by assessing the intertwin discordance rather than the individual fetal size. The aim of this study was to investigate the prediction of perinatal loss in twin pregnancy using discordance in fetal biometry and Doppler.

Study Design: This was a retrospective cohort study in a tertiary referral center. Read More

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http://dx.doi.org/10.1016/j.ajog.2015.02.024DOI Listing
August 2015
40 Reads

Fetal brain injury in survivors of twin pregnancies complicated by demise of one twin as assessed by in utero MR imaging.

Prenat Diagn 2015 Jun 18;35(6):583-91. Epub 2015 Mar 18.

Birmingham Centre of Women's and Children's Health, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK.

Objective: The aim of this study was to quantify the risk of brain abnormalities in single-twin demise of monochorionic pregnancies and to describe the type of brain injuries using ultrasound and in utero magnetic resonance (iuMR) imaging.

Methods: Monochorionic twin pregnancies complicated by the demise of one twin referred between 2004 and 2013 were reviewed. Ultrasound was performed in a tertiary centre prior to iuMR. Read More

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http://doi.wiley.com/10.1002/pd.4577
Publisher Site
http://dx.doi.org/10.1002/pd.4577DOI Listing
June 2015
8 Reads