4,859 results match your criteria Imaging in Dilated Cardiomyopathy


Case report: adult-onset manifesting heterozygous glycogen storage disease type IV with dilated cardiomyopathy and absent late gadolinium enhancement on cardiac magnetic resonance imaging.

Eur Heart J Case Rep 2020 Jun 3;4(3):1-6. Epub 2020 May 3.

Department of Radiology, Jacobi Medical Center, 1400 Pelham Pkwy S, Bronx, NY 10461, USA.

Background: Glycogen storage disease type IV (GSD IV; Andersen's disease) is a rare autosomal recessive disease caused by mutation in the GBE1 gene. Presentation of GSD IV varies on a continuum of severity and symptomatology ranging from neonatal death to mild adult-onset disease with variable involvement of hepatic, muscular, neurologic, dermatologic, and cardiac systems. Cardiomyopathy seen in GSD IV is also heterogeneous and its appearance on cardiac magnetic resonance imaging (CMR) is rarely described. Read More

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http://dx.doi.org/10.1093/ehjcr/ytaa078DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7319828PMC

Clinical outcomes after primary prevention defibrillator implantation are better predicted when the left ventricular ejection fraction is assessed by cardiovascular magnetic resonance.

J Cardiovasc Magn Reson 2020 Jun 25;22(1):48. Epub 2020 Jun 25.

Service de Cardiologie, EA4650 (Signalisation, électrophysiologie et imagerie des lésions d'ischémie-reperfusion myocardique), Normandie Univ, UNICAEN, CHU de Caen Normandie, 14000, Caen, France.

Background: The left ventricular ejection fraction (LVEF) is the key selection criterion for an implanted cardioverter defibrillator (ICD) in primary prevention of sudden cardiac death. LVEF is usually assessed by two-dimensional echocardiography, but cardiovascular magnetic resonance (CMR) imaging is increasingly used. The aim of our study was to evaluate whether LVEF assessment using CMR imaging (CMR-LVEF) or two-dimensional echocardiography (2D echo-LVEF) may predict differently the occurrence of clinical outcomes. Read More

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http://dx.doi.org/10.1186/s12968-020-00640-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7315498PMC

Biventricular Thrombi in Substance-Induced Dilated Cardiomyopathy.

CASE (Phila) 2020 Jun 20;4(3):170-174. Epub 2020 Feb 20.

Department of Cardiology, Gundersen Health System, La Crosse, Wisconsin.

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http://dx.doi.org/10.1016/j.case.2020.01.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7303235PMC

Clinical, pathological, imaging, and genetic characterization in a Taiwanese cohort with limb-girdle muscular dystrophy.

Orphanet J Rare Dis 2020 Jun 23;15(1):160. Epub 2020 Jun 23.

Baylor Genetics, Houston, TX, USA.

Background: Limb-girdle muscular dystrophy (LGMD) is a genetically heterogeneous, hereditary disease characterized by limb-girdle weakness and histologically dystrophic changes. The prevalence of each subtype of LGMD varies among different ethnic populations. This study for the first time analyzed the phenotypes and genotypes in Taiwanese patients with LGMD in a referral center for neuromuscular diseases (NMDs). Read More

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http://dx.doi.org/10.1186/s13023-020-01445-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7310488PMC

The phospholamban p.(Arg14del) pathogenic variant leads to cardiomyopathy with heart failure and is unreponsive to standard heart failure therapy.

Sci Rep 2020 Jun 17;10(1):9819. Epub 2020 Jun 17.

Department of Experimental Cardiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.

Phospholamban (PLN) plays a role in cardiomyocyte calcium handling as primary inhibitor of sarco/endoplasmic reticulum Ca-ATPase (SERCA). The p.(Arg14del) pathogenic variant in the PLN gene results in a high risk of developing dilated or arrhythmogenic cardiomyopathy with heart failure. Read More

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http://dx.doi.org/10.1038/s41598-020-66656-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7300032PMC

Reduction in Filamin C transcript is associated with arrhythmogenic cardiomyopathy in Ashkenazi Jews.

Int J Cardiol 2020 Apr 5. Epub 2020 Apr 5.

Heart Center, Sheba Medical Center, Tel Hashomer, Israel; Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel.

Background: Filamin C is a cytoskeletal protein expressed in cardiac cells. Nonsense variations in the filamin C gene (FLNC) were associated with dilated and arrhythmogenic cardiomyopathies.

Methods And Results: We identified an intronic variation in FLNC gene (c. Read More

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http://dx.doi.org/10.1016/j.ijcard.2020.04.005DOI Listing

Cold feet, warm heart.

Heart 2020 Jul;106(13):959-1032

Edinburgh Heart Centre, Royal Infirmary of Edinburgh, Edinburgh, UK.

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http://dx.doi.org/10.1136/heartjnl-2020-316815DOI Listing

X-linked dilated cardiomyopathy: the important role of genetic tests and imaging in the early diagnosis and treatment.

Future Cardiol 2020 Jun 8. Epub 2020 Jun 8.

Unit for Athletes & Hereditary Cardiovascular Diseases (EKKAN), 1st Cardiology Department, National & Kapodistrian University of Athens University Medical School, Hippokration Hospital, Athens, Greece.

Familial dilated cardiomyopathy predominantly affects younger adults and may cause advanced heart failure and sudden cardiac death. Therefore, detailed family history, family members screening, appropriate genetic testing and counselling may allow correct identification of cardiac remodeling etiology, as well as earlier disease detection. Accordingly, we present a case with an early diagnosis of an X-linked dilated cardiomyopathy guided by clinical features, cardiac MRI and genetic testing. Read More

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http://dx.doi.org/10.2217/fca-2020-0030DOI Listing

Clinical features and cardiovascular magnetic resonance characteristics in Danon disease.

Clin Radiol 2020 Jun 1. Epub 2020 Jun 1.

Department of Magnetic Resonance Imaging, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China; Key Laboratory of Cardiovascular Imaging (Cultivation), Chinese Academy of Medical Sciences, Beijing 100037, China. Electronic address:

Aims: To investigate the clinical spectrum, cardiovascular magnetic resonance imaging (cMRI) characteristics, including T1 and extracellular volume fraction, and outcomes of Danon disease to facilitate further understanding of the phenotype of patients with Danon disease.

Materials And Methods: The study comprised six male patients 8-23 years old recruited to the study between 2014-2019. The clinical presentation, laboratory examinations, pathology/genetic analysis, electrocardiography (ECG), echocardiography, and cCMRI characteristics were summarised. Read More

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http://dx.doi.org/10.1016/j.crad.2020.04.012DOI Listing

Ruptured cerebral mycotic aneurysm in a left ventricular assist device patient with bacteremia.

Int J Artif Organs 2020 May 30:391398820925493. Epub 2020 May 30.

Division of Cardiac Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.

A 50-year-old male with a history of nonischemic dilated cardiomyopathy presented in cardiogenic shock and ultimately underwent durable left ventricular assist device implantation. He recovered well initially but developed persistent bacteremia. His indwelling pacemaker leads were extracted due to evidence of vegetation. Read More

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http://dx.doi.org/10.1177/0391398820925493DOI Listing

Parameters of left ventricular systolic and diastolic dyssynchrony on radionuclide imaging to improve cardiac resynchronization therapy in heart failure patients with dilated cardiomyopathy.

J Nucl Cardiol 2020 May 26. Epub 2020 May 26.

Nuclear Cardiovascular Imaging Laboratory, Department of Cardiology, Westchester Medical Center, Valhalla, USA.

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http://dx.doi.org/10.1007/s12350-020-02202-4DOI Listing

The emerging spectrum of cardiopulmonary pathology of the coronavirus disease 2019 (COVID-19): Report of 3 autopsies from Houston, Texas, and review of autopsy findings from other United States cities.

Cardiovasc Pathol 2020 Sep - Oct;48:107233. Epub 2020 May 7.

Internal Medicine, McGovern Medical School, The University of Texas Health Science Center at Houston (UTHealth), Houston, Texas, USA; Center for Advanced Cardiopulmonary Therapies and Transplantation, McGovern Medical School and Memorial Hermann Hospital-Texas Medical Center, Houston, Texas, USA.

This paper collates the pathological findings from initial published autopsy reports on 23 patients with coronavirus disease 2019 (COVID-19) from 5 centers in the United States of America, including 3 cases from Houston, Texas. Findings confirm that COVID-19 is a systemic disease with major involvement of the lungs and heart. Acute COVID-19 pneumonia has features of a distinctive acute interstitial pneumonia with a diffuse alveolar damage component, coupled with microvascular involvement with intra- and extravascular fibrin deposition and intravascular trapping of neutrophils, and, frequently, with formation of microthombi in arterioles. Read More

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http://dx.doi.org/10.1016/j.carpath.2020.107233DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7204762PMC
July 2020
2.336 Impact Factor

Genetics of inherited cardiomyopathies in Africa.

Cardiovasc Diagn Ther 2020 Apr;10(2):262-278

Cardiovascular Genetics Laboratory, Hatter Institute for Cardiovascular Research in Africa, Department of Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa.

In sub-Saharan Africa (SSA), the burden of noncommunicable diseases (NCDs) is rising disproportionately in comparison to the rest of the world, affecting urban, semi-urban and rural dwellers alike. NCDs are predicted to surpass infections like human immunodeficiency virus, tuberculosis and malaria as the leading cause of mortality in SSA over the next decade. Heart failure (HF) is the dominant form of cardiovascular disease (CVD), and a leading cause of NCD in SSA. Read More

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http://dx.doi.org/10.21037/cdt.2019.10.03DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7225421PMC

Combination of extracellular volume fraction by cardiac magnetic resonance imaging and QRS duration for the risk stratification for patients with non-ischemic dilated cardiomyopathy.

Heart Vessels 2020 May 16. Epub 2020 May 16.

Department of Medical Science and Cardiorenal Medicine, Yokohama City University, Yokohama, Kanagawa, Japan.

The extracellular volume fraction (ECV) by T1 mapping can quantify diffuse myocardial fibrosis, and useful as a non-invasive marker for risk stratification for patients with non-ischemic dilated cardiomyopathy (NIDCM). Prolonged QRS interval on electrocardiogram is related to worse clinical outcome for heart failure patients. The purpose of this study was to evaluate the prognostic value of the combination of ECV and QRS duration for NIDCM patients. Read More

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http://dx.doi.org/10.1007/s00380-020-01618-9DOI Listing

Differentiating Athlete's Heart from Left Ventricle Cardiomyopathies.

J Cardiovasc Transl Res 2020 May 14. Epub 2020 May 14.

Instituto Cardiovascular, Hospital Clínic, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Centro de Investigación Biomédica en Red Enfermedades Cardiovasculares (CIBERCV), Barcelona, Spain.

Imaging techniques have allowed knowing the structural adaptative changes observed in the hearts of highly trained athletes. Athletes can develop very marked structural changes and the need may rise for a differential diagnosis with real cardiomyopathy. In this chapter, authors review the physiologic and morphologic features associated with athletic training and the keys to differentiate normal adaptive athlete's heart from mild or initial expression forms of left-heart side cardiomyopathies such as hypertrophic cardiomyopathy (HCM), dilated cardiomyopathy (DCM), and left ventricle non-compaction (LVNC). Read More

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http://dx.doi.org/10.1007/s12265-020-10021-8DOI Listing

Left ventricular systolic and diastolic dyssynchrony to improve cardiac resynchronization therapy response in heart failure patients with dilated cardiomyopathy.

J Nucl Cardiol 2020 May 13. Epub 2020 May 13.

College of Computing, Michigan Technological University, 1400 Townsend Dr, Houghton, MI, 49931, USA.

Background: The systolic and diastolic dyssynchrony is physiologically related, but measure different left ventricular mechanisms. Left ventricular systolic mechanical dyssynchrony (systolic LVMD) has shown significant clinical values in improving cardiac resynchronization therapy (CRT) response in the heart failure patients with dilated cardiomyopathy (DCM). Our recent study demonstrated that LV diastolic dyssynchrony (diastolic LVMD) parameters have important prognostic values for DCM patients. Read More

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http://dx.doi.org/10.1007/s12350-020-02132-1DOI Listing

Left Ventricular Aneurysm in a Child After Recovering From Dilated Cardiomyopathy.

World J Pediatr Congenit Heart Surg 2020 May 13:2150135120908208. Epub 2020 May 13.

Department of Cardiac Imaging, Inova Children's Hospital, Falls Church, VA, USA.

Left ventricular aneurysms are extremely rare in children. A child developed an aneurysm a year after recovering from idiopathic dilated cardiomyopathy. The initial management was conservative. Read More

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http://dx.doi.org/10.1177/2150135120908208DOI Listing

Two Cases of Cardiac Implantable Electronic Device Placement via Persistent Left Superior Vena Cava.

Eur J Case Rep Intern Med 2020 24;7(5):001484. Epub 2020 Mar 24.

Heart and Vascular Centre, Victoria Hospital Yangon, Myanmar.

Persistent left superior vena cava (PLSVC) is the most common variation of anomalous venous return to the heart and present in 0.1-0.5% of the general population. Read More

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http://dx.doi.org/10.12890/2020_001484DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7213826PMC

Cardiovascular magnetic resonance native T and T quantitative values for cardiomyopathies and heart transplantations: a systematic review and meta-analysis.

J Cardiovasc Magn Reson 2020 May 11;22(1):34. Epub 2020 May 11.

Department of Radiology, University Medical Center Groningen, University of Groningen, Hanzeplein 1, 9713 GZ, Groningen, The Netherlands.

Background: The clinical application of cardiovascular magnetic resonance (CMR) T and T mapping is currently limited as ranges for healthy and cardiac diseases are poorly defined. In this meta-analysis we aimed to determine the weighted mean of T and T mapping values in patients with myocardial infarction (MI), heart transplantation, non-ischemic cardiomyopathies (NICM) and hypertension, and the standardized mean difference (SMD) of each population with healthy controls. Additionally, the variation of mapping outcomes between studies was investigated. Read More

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http://dx.doi.org/10.1186/s12968-020-00627-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7212597PMC

Analysis of cardiac magnetic resonance imaging in 36,000 individuals yields genetic insights into dilated cardiomyopathy.

Nat Commun 2020 May 7;11(1):2254. Epub 2020 May 7.

Division of Cardiology, Massachusetts General Hospital, Boston, MA, USA.

Dilated cardiomyopathy (DCM) is an important cause of heart failure and the leading indication for heart transplantation. Many rare genetic variants have been associated with DCM, but common variant studies of the disease have yielded few associated loci. As structural changes in the heart are a defining feature of DCM, we report a genome-wide association study of cardiac magnetic resonance imaging (MRI)-derived left ventricular measurements in 36,041 UK Biobank participants, with replication in 2184 participants from the Multi-Ethnic Study of Atherosclerosis. Read More

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http://dx.doi.org/10.1038/s41467-020-15823-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7206184PMC

Familial screening in case of acute myocarditis reveals inherited arrhythmogenic left ventricular cardiomyopathies.

ESC Heart Fail 2020 May 1. Epub 2020 May 1.

l'Institut du Thorax, INSERM, CNRS, UNIV Nantes, CHU Nantes, Nantes, France.

Aims: Several data suggest that acute myocarditis could be related to genetic variants involved in familial cardiomyopathies, particularly arrhythmogenic cardiomyopathy, but the management of patients with acute myocarditis and their families regarding their risk for having an associated inherited cardiomyopathy is unclear.

Methods And Results: Families with at least one individual with a documented episode of acute myocarditis and at least one individual with a cardiomyopathy or a history of sudden death were included in the study. Comprehensive pedigree, including genetic testing, and history of these families were analysed. Read More

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http://dx.doi.org/10.1002/ehf2.12686DOI Listing

Cuba's Role in International Atomic Energy Agency Regional Cooperation in Cardiology.

MEDICC Rev 2019 Oct;21(4):78-81

Cardiovascular diseases are the leading cause of death worldwide, and a health problem in low- and middle-income as well as high-income countries. They also constitute the main cause of death in Latin America, with ischemic heart disease as the principal cause in most countries of the region. In Cuba, heart disease is the first cause of death, followed by cancer and stroke. Read More

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October 2019

Moving Toward Improved Risk Stratification in Patients With Dilated Cardiomyopathy.

Circ Cardiovasc Imaging 2020 Apr 21;13(4):e010629. Epub 2020 Apr 21.

Division of Cardiology, Section for Cardiac Electrophysiology, Hospital of the University of Pennsylvania, Philadelphia.

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http://dx.doi.org/10.1161/CIRCIMAGING.120.010629DOI Listing

Prognostic Value of Late Gadolinium Enhancement for the Prediction of Cardiovascular Outcomes in Dilated Cardiomyopathy: An International, Multi-Institutional Study of the MINICOR Group.

Circ Cardiovasc Imaging 2020 Apr 21;13(4):e010105. Epub 2020 Apr 21.

Departments of Cardiac Sciences and Diagnostic Imaging, Libin Cardiovascular Institute of Alberta, Calgary, Canada (S.D., J.F., J.A.W.).

Background: Dilated cardiomyopathy is associated with increased risk of major cardiovascular events. Late gadolinium enhancement (LGE) cardiac magnetic resonance imaging is a unique tissue-based marker that, in single-center studies, suggests strong prognostic value. We retrospectively studied associations between LGE presence and adverse cardiovascular events in patients with dilated cardiomyopathy in a multicenter setting as part of an emerging global consortium (MINICOR [Multi-Modal International Cardiovascular Outcomes Registry]). Read More

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http://dx.doi.org/10.1161/CIRCIMAGING.119.010105DOI Listing
April 2020
5.316 Impact Factor

Substrate for the Myocardial Inflammation-Heart Failure Hypothesis Identified Using Novel USPIO Methodology.

JACC Cardiovasc Imaging 2020 Apr 15. Epub 2020 Apr 15.

Manchester University NHS Foundation Trust, Wythenshawe Hospital, Manchester, United Kingdom; Division of Cardiovascular Sciences, University of Manchester, Manchester, United Kingdom; Wellcome Centre for Cell-Matrix Research, University of Manchester, Manchester, United Kingdom. Electronic address:

Objectives: The purpose of this study was to identify where ultrasmall superparamagnetic particles of iron oxide (USPIO) locate to in myocardium, develop a methodology that differentiates active macrophage uptake of USPIO from passive tissue distribution; and investigate myocardial inflammation in cardiovascular diseases.

Background: Myocardial inflammation is hypothesized to be a key pathophysiological mechanism of heart failure (HF), but human evidence is limited, partly because evaluation is challenging. USPIO-magnetic resonance imaging (MRI) potentially allows specific identification of myocardial inflammation but it remains unclear what the USPIO-MRI signal represents. Read More

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http://dx.doi.org/10.1016/j.jcmg.2020.02.001DOI Listing

Translational large animal model of hibernating myocardium: characterization by serial multimodal imaging.

Basic Res Cardiol 2020 Apr 14;115(3):33. Epub 2020 Apr 14.

Translational Laboratory for Cardiovascular Imaging and Therapy, Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), C/ Melchor Fernandez Almagro 3, Madrid, 28029, Spain.

Nonrevascularizable coronary artery disease is a frequent cause of hibernating myocardium leading to heart failure (HF). Currently, there is a paucity of therapeutic options for patients with this condition. There is a lack of animal models resembling clinical features of hibernating myocardium. Read More

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http://dx.doi.org/10.1007/s00395-020-0788-0DOI Listing
April 2020
5.414 Impact Factor

Is left bundle branch block pattern on the ECG caused by variable ventricular activation sequence?

Pacing Clin Electrophysiol 2020 05 28;43(5):486-494. Epub 2020 Apr 28.

Children's Heart Centre, Motol University Hospital, 1st and 2nd Faculty of Medicine, Charles University, Prague, Czech Republic.

Background: The presence and extent of ventricular dyssynchrony are currently assessed from the QRS complex morphology and width. However, similar electrocardiography (ECG) pattern may be caused by variable ventricular activation sequence. This may then contribute to interindividually different response to cardiac resynchronization therapy (CRT). Read More

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http://dx.doi.org/10.1111/pace.13914DOI Listing

Left-ventricular non-compaction-comparison between different techniques of quantification of trabeculations: Should the diagnostic thresholds be modified?

Arch Cardiovasc Dis 2020 May 2;113(5):321-331. Epub 2020 Apr 2.

Cardiology Department, La Timone Hospital, AP-HM, 13005 Marseille France; Aix Marseille Université, IRD, APHM, MEPHI, IHU - Méditerranée Infection, 13005 Marseille, France. Electronic address:

Background: Diagnosis of left ventricular non-compaction (LVNC) is challenging, and different imaging techniques propose different criteria.

Aim: To compare the value of two-dimensional transthoracic echocardiography (2D-TTE) and cardiac magnetic resonance (CMR) criteria in diagnosing LVNC, and to test a new trabecular quantification method obtained by 2D-TTE, exploring its relationship with CMR non-compacted mass quantification.

Methods: From a multicentre French study, we selected 48 patients with LVNC and 20 with dilated cardiomyopathy (DCM) who underwent 2D-TTE and CMR. Read More

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http://dx.doi.org/10.1016/j.acvd.2020.01.004DOI Listing

Predicting Sudden Death in Dilated Cardiomyopathy: The Potential Power of Magnetic Resonance Imaging as a Critical Tool.

Can J Cardiol 2019 Dec 31. Epub 2019 Dec 31.

Department of Medicine, University of Toronto, Toronto, Ontario, Canada; Division of Cardiology, St Michael's Hospital, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1016/j.cjca.2019.12.027DOI Listing
December 2019

Could myocardial viability be related to left ventricular dyssynchrony? Simultaneous evaluation by gated SPECT-MPI.

J Nucl Cardiol 2020 Apr 3. Epub 2020 Apr 3.

National Institute of Cardiology, Havana City, Cuba.

Background: Left ventricular contraction dyssynchrony (LVCD) has been related to induced ischemia and transmural scar but the interplay of myocardial viability and dyssynchrony is unknown. The aim of the present study was to establish the role of dyssynchrony in the context of a viability study performed with nitrate augmentation gated single photon emission computed tomography (GSPECT) myocardial perfusion imaging (MPI).

Methods: Fifty-four consecutive patients with ischemic dilated cardiomyopathy (IDC) and depressed left ventricular ejection fraction (LVEF) were included. Read More

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http://dx.doi.org/10.1007/s12350-020-02047-xDOI Listing

Looking at New Unexpected Disease Targets in -Linked Lipodystrophies in the Light of Complex Cardiovascular Phenotypes: Implications for Clinical Practice.

Cells 2020 Mar 20;9(3). Epub 2020 Mar 20.

Inserm UMRS938, Saint-Antoine Research Center, Sorbonne University, 75012 Paris, France.

Variants in , encoding A-type lamins, are responsible for laminopathies including muscular dystrophies, lipodystrophies, and progeroid syndromes. Cardiovascular laminopathic involvement is classically described as cardiomyopathy in striated muscle laminopathies, and arterial wall dysfunction and/or valvulopathy in lipodystrophic and/or progeroid laminopathies. We report unexpected cardiovascular phenotypes in patients with -associated lipodystrophies, illustrating the complex multitissular pathophysiology of the disease and the need for specific cardiovascular investigations in affected patients. Read More

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http://dx.doi.org/10.3390/cells9030765DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7140635PMC

The electrocardiogram in the diagnosis and management of patients with dilated cardiomyopathy.

Eur J Heart Fail 2020 Apr 3. Epub 2020 Apr 3.

Cardiovascular Department, A.O.U. Ospedali Riuniti, Trieste, Italy.

The term dilated cardiomyopathy (DCM) defines a heterogeneous group of cardiac disorders, which are characterized by left ventricular or biventricular dilatation and systolic dysfunction in the absence of abnormal loading conditions or coronary artery disease sufficient to cause global systolic impairment. In approximately one third of cases, DCM is familial with a genetic pathogenesis and various patterns of inheritance. Although the electrocardiogram (ECG) has been considered traditionally non-specific in DCM, the recently acquired knowledge of the genotype-phenotype correlations provides novel opportunities to identify patterns and abnormalities that may point toward specific DCM subtypes. Read More

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http://dx.doi.org/10.1002/ejhf.1815DOI Listing

Prognostic Implications of Left Ventricular Global Longitudinal Strain in Dilated Cardiomyopathy.

Authors:
Mi Young Park

J Cardiovasc Imaging 2020 Apr;28(2):150-151

Division of Cardiology, Department of Internal Medicine, Sejong General Hospital, Bucheon, Korea.

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http://dx.doi.org/10.4250/jcvi.2020.0031DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7114446PMC

Left Ventricular Global Longitudinal Strain as a Predictor for Left Ventricular Reverse Remodeling in Dilated Cardiomyopathy.

J Cardiovasc Imaging 2020 Apr;28(2):137-149

Division of Cardiology, Sanggye-Paik Hospital, Inje University, Seoul, Korea.

Background: A considerable number of patients with dilated cardiomyopathy (DCM) experience left ventricular reverse remodeling (LVRR). LV global longitudinal strain (LV GLS) offers sensitive and reproducible measurement of myocardial dysfunction. The authors sought to evaluate whether LV GLS at the time of diagnosis may predict LVRR in DCM patients with sinus rhythm and investigate its prognostic role in long-term follow-up in this population. Read More

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http://dx.doi.org/10.4250/jcvi.2019.0111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7114450PMC

Multiparametric Differentiation of Idiopathic Dilated Cardiomyopathy With and Without Congestive Heart Failure by Means of Cardiac and Hepatic T1-Weighted MRI Mapping.

AJR Am J Roentgenol 2020 Jul 24;215(1):79-86. Epub 2020 Mar 24.

Laboratoire d'Imagerie Biomédicale, Sorbonne Université, INSERM, Paris, France.

The purpose of this study was to test the hypothesis that patients with idiopathic dilated cardiomyopathy (IDCM) and heart failure have increased liver T1 relaxation times at MRI owing to congestion compared with the T1 relaxation times in patients with IDCM without heart failure and healthy control subjects. For this retrospective cross-sectional study, 55 subjects (33 men, 22 women; mean age, 47 ± 15 years) who had undergone cardiac MRI were included: 20 healthy control subjects and 35 consecutively registered patients with IDCM. Twenty-one patients were hospitalized for acute heart failure, and 14 patients were in stable condition without heart failure. Read More

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http://dx.doi.org/10.2214/AJR.19.22009DOI Listing

Emerging Techniques for Risk Stratification in Nonischemic Dilated Cardiomyopathy: JACC Review Topic of the Week.

J Am Coll Cardiol 2020 Mar;75(10):1196-1207

Department of Cardiovascular Sciences, University of Leicester and the National Institute for Health Research (NIHR) Leicester Biomedical Research Centre, Glenfield Hospital, Leicester, United Kingdom. Electronic address:

Dilated cardiomyopathy (DCM) is a common condition, which carries significant mortality from sudden cardiac death and pump failure. Left ventricular ejection fraction has conventionally been used as a risk marker for sudden cardiac death, but has performed poorly in trials. There have been significant advances in the areas of cardiac magnetic resonance imaging and genetics, which are able to provide useful rick prediction in DCM. Read More

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http://dx.doi.org/10.1016/j.jacc.2019.12.058DOI Listing

Comprehensive identification of signaling pathways for idiopathic pulmonary arterial hypertension.

Am J Physiol Cell Physiol 2020 May 11;318(5):C913-C930. Epub 2020 Mar 11.

Department of Pathophysiology, School of Basic Medicine, and Key Laboratory of Pulmonary Diseases of Ministry of Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Whole exome sequencing (WES) was used in the research of familial pulmonary arterial hypertension (FPAH). and were found as two novel candidate genes of FPAH. However, few pathogenic genes were identified in idiopathic pulmonary arterial hypertension (IPAH). Read More

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http://dx.doi.org/10.1152/ajpcell.00382.2019DOI Listing

The Role of Multimodality Cardiovascular Imaging in Peripartum Cardiomyopathy.

Front Cardiovasc Med 2020 18;7. Epub 2020 Feb 18.

Department of Neuroscience, Imaging and Clinical Sciences, "G. D'Annunzio" University, Chieti, Italy.

The burden of pregnancy-related heart disease has dramatically increased over the last decades due to the increasing age at first pregnancy and higher prevalence of cardiovascular risk factors such as diabetes, hypertension, and obesity. Pregnancy is associated with physiological changes in the cardiovascular system, including hemodynamic, metabolic, and hormonal adaptations to meet the increased metabolic demands of the mother and fetus. It has been postulated that pregnancy may act as a cardiovascular stress test to identify women at high risk for heart disease, where the inability to adequately adapt to the physiologic stress of pregnancy may reveal the presence of genetic susceptibility to cardiovascular disease or accelerate the phenotypic expression of both inherited and acquired heart diseases, such as peripartum cardiomyopathy (PPCM). Read More

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http://dx.doi.org/10.3389/fcvm.2020.00004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7041418PMC
February 2020

Left ventricular global myocardial strain assessment: Are CMR feature-tracking algorithms useful in the clinical setting?

Radiol Med 2020 May 3;125(5):444-450. Epub 2020 Mar 3.

Department of Imaging and Pathology, KU Leuven - University of Leuven, Herestraat 49, 3000, Leuven, Belgium.

Objectives: Myocardial strains can be calculated using cardiovascular magnetic resonance (CMR) feature-tracking (FT) algorithms. They show excellent intra- and inter-observer agreement but rather disappointing inter-vendor agreement. Currently, it is unknown how well CMR-FT-based strain values agree with manually obtained strain values. Read More

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http://dx.doi.org/10.1007/s11547-020-01159-1DOI Listing

Sarcoidosis diagnosed on granulomas in the explanted heart after transplantation: Results of a French nationwide study.

Int J Cardiol 2020 May 17;307:94-100. Epub 2020 Jan 17.

Sorbonne Université, Assistance Publique-Hôpitaux de Paris, Hôpital De la Pitié-Salpêtrière, Service de Médecine Interne 2, Centre de Référence National Maladies Systémiques Rares, 75013 Paris, France. Electronic address:

Background: Cardiac sarcoidosis (CS) is a challenging diagnosis. Patients may progress to end-stage congestive heart failure and require cardiac transplantation without ever having been diagnosed. Characteristics and outcomes of patients with granulomas in the explanted hearts are unknown. Read More

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http://dx.doi.org/10.1016/j.ijcard.2019.12.066DOI Listing

Equilibrium radionuclide angiography compared with tissue doppler imaging for detection of right ventricular dyssynchrony and prediction of acute response to cardiac resynchronization therapy.

Medicine (Baltimore) 2020 Feb;99(9):e19296

Department of Cardiology.

Objective: The aim of this study was to compare tissue doppler imaging (TDI) and equilibrium radionuclide angiography (ERNA) for detection of right ventricular (RV) dyssynchrony and prediction of the acute response to cardiac resynchronization therapy (CRT).

Methods: This study was approved by the local ethics committee of Huai'an First People's Hospital. Patient consent was not provided due to the use of completely anonymous images from which the individual could not be identified in this study. Read More

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http://dx.doi.org/10.1097/MD.0000000000019296DOI Listing
February 2020

Arrhythmogenic Right Ventricular Cardiomyopathy: Characterization of Left Ventricular Phenotype and Differential Diagnosis With Dilated Cardiomyopathy.

J Am Heart Assoc 2020 Mar 2;9(5):e014628. Epub 2020 Mar 2.

Department of Cardio-Thoraco-Vascular Sciences and Public Health University of Padua Italy.

Background This study assessed the prevalence of left ventricular (LV) involvement and characterized the clinical, electrocardiographic, and imaging features of LV phenotype in patients with arrhythmogenic right ventricular cardiomyopathy (ARVC). Differential diagnosis between ARVC-LV phenotype and dilated cardiomyopathy (DCM) was evaluated. Methods and Results The study population included 87 ARVC patients (median age 34 years) and 153 DCM patients (median age 51 years). Read More

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http://dx.doi.org/10.1161/JAHA.119.014628DOI Listing

Clinical Characteristics and Prognostic Factors of Myocarditis in New Zealand Patients.

Heart Lung Circ 2020 Feb 17. Epub 2020 Feb 17.

Cardiovascular Division, North Shore Hospital, Waitemata District Health Board, Auckland, New Zealand.

Background: Myocarditis is an inflammation of the heart muscle and an important cause of dilated cardiomyopathy. Its presentation is heterogeneous, and there are limited studies describing the clinical characteristics of these patients, or which factors predict adverse clinical outcomes. We performed a single-centre retrospective study to explore the clinical characteristics of patients with myocarditis. Read More

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http://dx.doi.org/10.1016/j.hlc.2020.01.007DOI Listing
February 2020

Echocardiography in Athletes in Primary Prevention of Sudden Death.

J Cardiovasc Echogr 2019 Oct-Dec;29(4):139-148

Department of Cardiology, Luigi Vanvitelli University of Naples, Monaldi Hospital, Naples, Italy.

Echocardiography is a noninvasive imaging technique useful to provide clinical data regarding physiological adaptations of athlete's heart. Echocardiographic characteristics may be helpful for the clinicians to identify structural cardiac disease, responsible of sudden death during sport activities. The application of echocardiography in preparticipation screening might be essential: it shows high sensitivity and specificity for identification of structural cardiac disease and it is the first-line imagining technique for primary prevention of SCD in athletes. Read More

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http://dx.doi.org/10.4103/jcecho.jcecho_26_19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7011488PMC
February 2020

First magnetic resonance imaging-guided cardiac radioablation of sustained ventricular tachycardia.

Radiother Oncol 2020 Feb 14. Epub 2020 Feb 14.

Department of Radiation Oncology, University Hospital Zurich, University of Zurich, Switzerland.

Purpose: To report the feasibility of magnetic resonance imaging-guided cardiac single fraction radioablation (MRgRA) in a patient with dilated cardiomyopathy and recurrent sustained ventricular tachycardia (VT) leading to electrical storms (ES).

Materials/methods: A workflow to perform Stereotactic Arrhythmia Radioablation (STAR) on a hybrid MR-Linac with real-time tracking and beam-gating was established. Challenges of the MRgRA approach included: (a) the safety of a non-MR compatible cardiac implantable electronic device (CIED) in the MR-Linac field, (b) artefacts caused by the CIED and (c) respiratory motion management with cine-tracking of the moving heart. Read More

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http://dx.doi.org/10.1016/j.radonc.2020.01.008DOI Listing
February 2020