4,591 results match your criteria Imaging in Dilated Cardiomyopathy


Patients with Isolated Focal Right Ventricular Dyskinetic Segments: Toward a Better Understanding of This Cohort.

J Cardiovasc Imaging 2019 Apr;27(2):93-101

Division of Cardiovascular Medicine, Clemenceau Medical Center, Beirut, Lebanon.

Background: The 2010 revised Task Force criteria for the diagnosis of arrhythmogenic right ventricular cardiomyopathy (ARVC) provided guidance for the classification of patients as definitive, borderline or possible ARVC. However, many patients with clinical suspicion for ARVC have isolated RV dyskinetic segments only and partly meet cardiac magnetic resonance (CMR) imaging criteria. This subgroup of patients and the implication of this imaging finding remain not well defined. Read More

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http://dx.doi.org/10.4250/jcvi.2019.27.e16DOI Listing

Heart failure in cardiomyopathies: a position paper from the Heart Failure Association of the European Society of Cardiology.

Eur J Heart Fail 2019 Apr 16. Epub 2019 Apr 16.

Berlin-Brandenburg Center for Regenerative Therapies, Deutsches Zentrum für Herz-Kreislauf-Forschung (DZHK) Berlin, Department of Cardiology, Campus Virchow Klinikum, Charite - Universitaetsmedizin Berlin, Berlin, Germany.

Cardiomyopathies are a heterogeneous group of heart muscle diseases and an important cause of heart failure (HF). Current knowledge on incidence, pathophysiology and natural history of HF in cardiomyopathies is limited, and distinct features of their therapeutic responses have not been systematically addressed. Therefore, this position paper focuses on epidemiology, pathophysiology, natural history and latest developments in treatment of HF in patients with dilated (DCM), hypertrophic (HCM) and restrictive (RCM) cardiomyopathies. Read More

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http://dx.doi.org/10.1002/ejhf.1461DOI Listing
April 2019
6.526 Impact Factor

Nexilin is a New Component of Junctional Membrane Complexes Required for Cardiac T-Tubule Formation.

Circulation 2019 Apr 15. Epub 2019 Apr 15.

Department of Medicine, University of California San Diego, La Jolla, CA.

Background: Membrane contact sites (MCS) are fundamental for transmission and translation of signals in multicellular organisms. A prime example is junctional membrane complexes (JMC) in the cardiac dyads, where T-tubules are juxtaposed to the sarcoplasmic reticulum (SR). T-tubule uncoupling and remodeling are well-known features of cardiac disease and heart failure. Read More

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http://dx.doi.org/10.1161/CIRCULATIONAHA.119.039751DOI Listing

Left ventricular apical hypertrophy in a transplanted heart: a case report.

BMC Cardiovasc Disord 2019 Apr 3;19(1):81. Epub 2019 Apr 3.

Department of Cardiology, St Francis Hospital and Medical Center, 114 Woodland St, Hartford, CT, 06105, USA.

Background: Left ventricular apical hypertrophic cardiomyopathy is a rare presentation of hypertrophic cardiomyopathy associated with thickening of the apical segment of the left ventricle. It was initially described in Japan in 1976 and is characterized by electrocardiogram findings showing giant T wave inversions in the precordial leads as well as a spade shaped appearance of the apical cavity on imaging (Abugroun et al., Cardiol Res 8:265-268, 2017). Read More

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http://dx.doi.org/10.1186/s12872-019-1069-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6446306PMC
April 2019
4 Reads

[Mitral Regurgitation Repaired by Papillary Heads Optimization Technique].

Kyobu Geka 2019 Mar;72(3):184-189

Department of Cardiovascular Surgery, Kagoshima University Hospital, Kagoshima, Japan.

Functional mitral regurgitation( FMR) is a risk factor that increases the mortality rate and incidence of heart failure. Surgical intervention is important. Mitral valve (MV) reconstruction can preserve the valvular apparatus;no anticoagulation therapy is required, left ventricular function is preserved. Read More

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March 2019
1 Read

A large deletion in RYR2 exon 3 is associated with nadolol and flecainide refractory catecholaminergic polymorphic ventricular tachycardia.

Pacing Clin Electrophysiol 2019 Mar 25. Epub 2019 Mar 25.

Center for Arrhythmia Care, Heart & Vascular Center, Pritzker School of Medicine of the University of Chicago, Chicago, Illinois.

We report a 17-year-old boy with a large RYR2 exon 3 deletion who has a severe catecholaminergic polymorphic ventricular tachycardia (CPVT) phenotype characterized by refractoriness to both nadolol and flecainide which has previously not been reported in this subgroup of CPVT patients. Treatment options in a patient like ours are therefore limited and sympathectomy and implantable cardioverter-defibrillator implantation should be considered early in the treatment course as was done in this patient. In contrast to other CPVT patients who do not usually have structural cardiac abnormalities, these patients are at a high risk of developing left ventricular noncompaction or dilated cardiomyopathy and therefore might benefit from cardiac imaging at regular intervals. Read More

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http://dx.doi.org/10.1111/pace.13668DOI Listing
March 2019
1 Read

Molecular characterization of Portuguese patients with dilated cardiomyopathy.

Rev Port Cardiol 2019 Feb 11;38(2):129-139. Epub 2019 Mar 11.

Department of Medicine, Faculty of Medicine, University of Porto, Portugal; I3S - Institute for Innovation and Health Research, Portugal; Department of Cardiology, São João Hospital Center, Portugal.

Introduction: Dilated cardiomyopathy (DCM) is a disease of the heart muscle characterized by ventricular dilatation and impaired systolic function. Familial forms account for 30-50% of cases. Autosomal dominant inheritance is the predominant pattern of transmission. Read More

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http://dx.doi.org/10.1016/j.repc.2018.10.010DOI Listing
February 2019
2 Reads

Doxorubicin Exposure Causes Subacute Cardiac Atrophy Dependent on the Striated Muscle-Specific Ubiquitin Ligase MuRF1.

Circ Heart Fail 2019 Mar;12(3):e005234

McAllister Heart Institute (T.L.P., D.I.B., R.I.M., W.H., B.C.J.), University of North Carolina School of Medicine, Chapel Hill.

Background Anthracycline chemotherapeutics, such as doxorubicin, are used widely in the treatment of numerous malignancies. The primary dose-limiting adverse effect of anthracyclines is cardiotoxicity that often presents as heart failure due to dilated cardiomyopathy years after anthracycline exposure. Recent data from animal studies indicate that anthracyclines cause cardiac atrophy. Read More

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http://dx.doi.org/10.1161/CIRCHEARTFAILURE.118.005234DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6422170PMC
March 2019
8 Reads
5.891 Impact Factor

Clinical presentation and early predictors for poor outcomes in pediatric myocarditis: A retrospective study.

World J Clin Cases 2019 Mar;7(5):548-561

Department of Pediatric Nephrology, Puerta del Mar University Hospital, Cadiz 11009, Spain.

Background: Myocarditis is an important cause of morbidity and mortality in children, leading to long-term sequelae including chronic congestive heart failure, dilated cardiomyopathy, heart transplantation, and death. The initial diagnosis of myocarditis is usually based on clinical presentation, but this widely ranges from the severe sudden onset of a cardiogenic shock to asymptomatic patients. Early recognition is essential in order to monitor and start supportive treatment prior to the development of severe adverse events. Read More

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https://www.wjgnet.com/2307-8960/full/v7/i5/548.htm
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http://dx.doi.org/10.12998/wjcc.v7.i5.548DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6406197PMC
March 2019
2 Reads

SLMAP-3 is downregulated in human dilated ventricles and its overexpression promotes cardiomyocyte response to adrenergic stimuli by increasing intracellular calcium.

Can J Physiol Pharmacol 2019 Mar 11. Epub 2019 Mar 11.

King Faisal Specialist Hospital and Research Center, 37852, Department of Genetics, , P.O. Box 3354 , 11211 , Riyadh, Saudi Arabia , 11211.

Structural dilation of cardiomyocytes (CMs) imposes a decline in cardiac performance that precipitates cardiac failure and sudden death. Since membrane proteins are implicated in dilated cardiomyopathy and heart failure, we evaluated the expression of the sarcolemmal membrane-associated protein (SLMAP) in dilated cardiomyopathy and its effect on CM contraction. We found that all three SLMAP isoforms (SLMAP-1, -2, and -3) are expressed in CMs and are downregulated in human dilated ventricles. Read More

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http://dx.doi.org/10.1139/cjpp-2018-0660DOI Listing
March 2019
1 Read

Pathophysiological background and prognostic implication of systolic aortic root motion in non-ischemic dilated cardiomyopathy.

Sci Rep 2019 Mar 7;9(1):3866. Epub 2019 Mar 7.

Department of Internal Medicine III, Cardiology, Angiology and Pneumology, University of Heidelberg, Heidelberg, Germany.

Recordings of aortic root movement represent one of the first accomplishments of ultrasound in medicine and mark the beginning of functional cardiac imaging. However, the underlying mechanism is not completely understood. Since the aortic root is directly connected to the cardiac skeleton we hypothesize, that the amplitude of systolic aortic root motion (SARM) may be mainly caused by displacement of the cardiac base towards the apex and might therefore be used as measure of left ventricular longitudinal function (LV-LF). Read More

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http://dx.doi.org/10.1038/s41598-019-40386-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6405754PMC
March 2019
3 Reads

Therapeutic Advances in Emergency Cardiology: A Focus on Acute Myocarditis.

Am J Ther 2019 Mar/Apr;26(2):e294-e300

Cardiology Department, Victor Babeş University of Medicine and Pharmacy, Timişoara, Romania.

Background: Myocarditis, defined as an inflammation of the myocardium, is an important cause of dilated cardiomyopathy and congestive heart failure. Unfortunately, its diagnosis and etiology is often challenging in clinical practice, and thus, improving diagnosis and therapeutic approach of this cardiac pathology is a matter of great interest.

Areas Of Uncertainty: The etiology of the disease may be represented by not only infectious agents, usually with viral determination, but also autoimmune and systemic diseases or drugs. Read More

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http://dx.doi.org/10.1097/MJT.0000000000000921DOI Listing
March 2019
2 Reads

Glucagonoma-associated dilated cardiomyopathy refractory to somatostatin analogue therapy.

Endocrinol Diabetes Metab Case Rep 2019 Mar 5;2019. Epub 2019 Mar 5.

Wolfson Diabetes & Endocrine Clinic, Cambridge University Hospitals NHS Foundation Trust.

A 67-year-old woman presented with a generalised rash associated with weight loss and resting tachycardia. She had a recent diagnosis of diabetes mellitus. Biochemical evaluation revealed elevated levels of circulating glucagon and chromogranin B. Read More

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http://dx.doi.org/10.1530/EDM-18-0157DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6432982PMC
March 2019
5 Reads

Tricuspid valve dysplasia and a patent foramen ovale resulting in severe tricuspid regurgitation and right-heart dilation in a Red Angus calf.

J Vet Cardiol 2019 Feb 11;21:28-33. Epub 2018 Dec 11.

Department of Medical Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, 2015 Linden Drive, Madison, WI 53706, USA.

A two-month-old Red Angus heifer calf presented to the University of Wisconsin Veterinary Care for evaluation of suspected severe bronchopneumonia. Pertinent physical exam findings included tachycardia, tachypnea, dyspnea with a significant abdominal component, and cyanotic mucous membranes. On thoracic auscultation, wheezes were present bilaterally, as well as a grade 2/6 right apical systolic murmur. Read More

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http://dx.doi.org/10.1016/j.jvc.2018.10.005DOI Listing
February 2019
1 Read

Association between atrial fibrillation and right-sided manifestations of congestive heart failure in dogs with degenerative mitral valve disease or dilated cardiomyopathy.

J Vet Cardiol 2019 Feb 11;21:18-27. Epub 2018 Dec 11.

Department of Veterinary Pathology, College of Veterinary Medicine, Iowa State University, 1809 S. Riverside Drive, Ames, IA 50011, USA.

Introduction: To determine whether dogs with atrial fibrillation (AF) are more likely to develop right-sided manifestations of congestive heart failure (R-CHF) than dogs without AF.

Animals: Two hundred twenty dogs diagnosed with congestive heart failure (CHF) secondary to degenerative mitral valve disease (DMVD, n = 155) or dilated cardiomyopathy (DCM, n = 65) at a referral institution.

Methods: Medical records were reviewed to extract relevant clinical and echocardiographic data. Read More

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http://dx.doi.org/10.1016/j.jvc.2018.10.006DOI Listing
February 2019
2 Reads

Echocardiographic phenotype of canine dilated cardiomyopathy differs based on diet type.

J Vet Cardiol 2019 Feb 5;21:1-9. Epub 2018 Dec 5.

College of Veterinary Medicine, North Carolina State University, 1060 William Moore Dr., Raleigh, NC, 27607, USA.

Introduction: Canine dilated cardiomyopathy (DCM) can result from numerous etiologies including genetic mutations, infections, toxins, and nutritional imbalances. This study sought to characterize differences in echocardiographic findings between dogs with DCM fed grain-free (GF) diets and grain-based (GB) diets.

Animals: Forty-eight dogs with DCM and known diet history. Read More

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http://dx.doi.org/10.1016/j.jvc.2018.11.002DOI Listing
February 2019
2 Reads

The prognostic value of 2D strain in assessment of the right ventricle in patients with dilated cardiomyopathy.

Eur Heart J Cardiovasc Imaging 2019 Feb 22. Epub 2019 Feb 22.

Department of Cardiology, Sanggye-Paik Hospital, Inje University College of Medicine, Sanggye-dong, Nowon-gu, Seoul, Republic of Korea.

Aims: Several studies have been reported using right ventricular (RV) strain as a method for evaluating RV function in patients with various cardiovascular diseases; however, the clinical relevance of RV strain in dilated cardiomyopathy (DCM) patients with sinus rhythm is unknown. The aim of this study was to investigate the relationship between RV strain and adverse events in DCM patients with sinus rhythm.

Methods And Results: We enrolled 143 DCM patients with sinus rhythm who had been first diagnosed, evaluated, and followed at Sanggye Paik Hospital between March 2013 and August 2017. Read More

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https://academic.oup.com/ehjcimaging/advance-article/doi/10.
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http://dx.doi.org/10.1093/ehjci/jez015DOI Listing
February 2019
11 Reads

Effects of triptolide and methotrexate nanosuspensions on left ventricular remodeling in autoimmune myocarditis rats.

Int J Nanomedicine 2019 29;14:851-863. Epub 2019 Jan 29.

Department of Chemical Engineering, Northeastern University, Boston, MA 02115, USA,

Purpose: This study was carried out to investigate the effects of a triptolide (TP) nanosuspension and methotrexate (MTX) nanosuspension on left ventricular remodeling and cardiac function for autoimmune myocarditis (EAM) in rats. The regulating effects on inflammatory cytokines in the peripheral serum and related mechanisms are also discussed.

Methods: First, TP and MTX were prepared as a nanosuspension, and the EAM model was successfully established in rats with cardiac myosin. Read More

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http://dx.doi.org/10.2147/IJN.S191267DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6361222PMC
March 2019
1 Read

Relationship between left ventricular vortex and preejectional flow velocity during isovolumic contraction studied by using vector flow mapping.

Echocardiography 2019 03 6;36(3):558-566. Epub 2019 Feb 6.

Department of Ultrasound, PLA 967th Hospital, Dalian, China.

Objectives: The purpose of this study was to investigate the relationship between the vortex in left ventricle (LV) during the isovolumic contraction (IVC) period and the preejectional flow velocity in LV outflow tract (V ).

Methods: Color Doppler loops were acquired for vector flow mapping in apical long-axis view in 76 patients with dilated cardiomyopathy, 61 patients with coronary artery disease and 36 healthy controls.

Results: All normals exhibited an IVC vortex reaching the LV base. Read More

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http://dx.doi.org/10.1111/echo.14277DOI Listing
March 2019
1 Read

Heart rate reduction strategy using ivabradine in end-stage Duchenne cardiomyopathy.

Int J Cardiol 2019 Apr 17;280:99-103. Epub 2019 Jan 17.

Department of Pediatric Cardiology and Cardiac Surgery, Cardiology Unit, Bambino Gesù Hospital & Research Institute, Rome, Italy.

Background: End-stage dilated cardiomyopathy (DCM) is the leading cause of morbidity and mortality in patients with Duchenne Muscular Dystrophy (DMD). No studies are available on the effect of ivabradine on long-term outcomes in end-stage DMD/DCM.

Methods: We prospectively enrolled a cohort of end-stage DMD/DCM patients with LV ejection fraction <40%, on chronic HF treatment with an ACE inhibitor referred consecutively from 2012 to 2017 to Bambino Gesù Children's Hospital. Read More

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http://dx.doi.org/10.1016/j.ijcard.2019.01.052DOI Listing
April 2019
2 Reads

Ioxynil and diethylstilbestrol disrupt vascular and heart development in zebrafish.

Environ Int 2019 Mar 25;124:511-520. Epub 2019 Jan 25.

Centre of Marine Sciences, University of Algarve, Faro, Portugal. Electronic address:

Background: Endocrine disruption is one of the consequences of industrialization and chemicals released into the environment have a profound impact on organisms. Waterborne micromolar concentrations of ioxynil (IOX) and diethylstilbestrol (DES) in fish affect the development of the heart, vasculature and thyroid gland.

Objectives: The present study aimed to determine how IOX and DES disrupt the crosstalk between the developing thyroid gland and cardio-vascular system in zebrafish. Read More

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http://dx.doi.org/10.1016/j.envint.2019.01.009DOI Listing
March 2019
3 Reads

Speckle-Tracking Echocardiography in Children With Duchenne Muscular Dystrophy: A Prospective Multicenter Controlled Cross-Sectional Study.

J Am Soc Echocardiogr 2019 Mar 21;32(3):412-422. Epub 2019 Jan 21.

PHYMEDEXP, University of Montpellier, CNRS, INSERM, CHU Montpellier, Montpellier, France.

Background: Prognosis of Duchenne muscular dystrophy (DMD) is related to cardiac dysfunction. Speckle-tracking echocardiographic (STE) imaging is emerging as a noninvasive functional biomarker to consider in the early detection of DMD-related cardiomyopathy. However, STE analysis has not been assessed in a prospectively controlled study, especially in presymptomatic children with DMD, and no study has used STE analysis in all three displacements (longitudinal, radial, and circumferential) and for both ventricles. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S08947317183060
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http://dx.doi.org/10.1016/j.echo.2018.10.017DOI Listing
March 2019
12 Reads
4.056 Impact Factor

Long term prognostic importance of late gadolinium enhancement in first-presentation non-ischaemic dilated cardiomyopathy.

Int J Cardiol 2019 Apr 9;280:124-129. Epub 2019 Jan 9.

College of Medicine and Public Health, Flinders University, Australia; Department of Cardiovascular Medicine, Flinders Medical Centre, Australia; Cardiac Imaging Research Group, South Australian Health & Medical Research Institute, Australia. Electronic address:

Background: Presence of myocardial fibrosis in well-established non-ischaemic dilated cardiomyopathy (NIDCM) is associated with adverse clinical outcomes. However, the impact of myocardial fibrosis at first presentation in NIDCM, and its long-term association with left ventricular (LV) dysfunction, heart failure (HF) and ventricular arrhythmia (VA) remains unclear. We investigated whether the presence of myocardial fibrosis quantified by late gadolinium enhancement cardiovascular magnetic resonance (LGE-CMR) at presentation, is independently associated with long-term major adverse cardiovascular events (MACE) in patients with first presentation NIDCM. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01675273183484
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http://dx.doi.org/10.1016/j.ijcard.2019.01.018DOI Listing
April 2019
5 Reads

Left Ventricular Torsion - A New Echocardiographic Prognosticator in Patients With Non-Ischemic Dilated Cardiomyopathy.

Circ J 2019 Feb 20;83(3):595-603. Epub 2019 Jan 20.

Department for Internal Medicine and Cardiology, Herzzentrum Dresden, Technische Universität Dresden.

Background: Left ventricular (LV) torsion is a key parameter in cardiac function and predicts functional capacity (FC) more appropriately than LV ejection fraction (EF). We sought to investigate LV torsion as a marker of hospitalization for worsening heart failure (HF) in non-ischemic dilated cardiomyopathy (DCM) patients. Methods and Results: The 91 outpatients with newly diagnosed DCM (53±13 years, 20% female) were evaluated with 3D speckle-tracking imaging and followed up for 12 months; 43 healthy sex- and age-matched volunteers served as controls. Read More

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http://dx.doi.org/10.1253/circj.CJ-18-0986DOI Listing
February 2019
2 Reads

Microvascular Dysfunction in Dilated Cardiomyopathy: A Quantitative Stress Perfusion Cardiovascular Magnetic Resonance Study.

JACC Cardiovasc Imaging 2019 Jan 9. Epub 2019 Jan 9.

Royal Brompton Hospital, London, United Kingdom; Imperial College London, London, United Kingdom.

Objectives: This study sought to quantify myocardial blood flow (MBF) and myocardial perfusion reserve (MPR) in dilated cardiomyopathy (DCM) and examine the relationship between myocardial perfusion and adverse left ventricular (LV) remodeling.

Background: Although regarded as a nonischemic condition, DCM has been associated with microvascular dysfunction, which is postulated to play a role in its pathogenesis. However, the relationship of the resulting perfusion abnormalities to myocardial fibrosis and the degree of LV remodeling is unclear. Read More

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http://dx.doi.org/10.1016/j.jcmg.2018.10.032DOI Listing
January 2019
4 Reads

Absolute Myocardial Blood Flow in Dilated Cardiomyopathy: Does it Matter?

JACC Cardiovasc Imaging 2019 Jan 9. Epub 2019 Jan 9.

Cardio-Thoracic and Vascular Department, University Hospital of Pisa, Pisa, Italy.

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http://dx.doi.org/10.1016/j.jcmg.2018.12.002DOI Listing
January 2019
2 Reads

Pheochromocytoma-related cardiomyopathy presenting as broken heart syndrome: Case report and literature review.

Int J Surg Case Rep 2019 9;55:7-10. Epub 2019 Jan 9.

Department of Surgery, Kendall Regional Medical Center, Miami, FL, United States.

Introduction: Pheochromocytoma are neuroendocrine tumors that arise from sympathetic chromaffin cells within the adrenal medulla. They principally secrete catecholamines, potentially causing life-threatening cardiovascular complications. A myriad of symptomatology and clinical findings are associated with pheochromocytoma, including a catecholamine-induced dilated cardiomyopathy. Read More

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http://dx.doi.org/10.1016/j.ijscr.2018.12.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6330378PMC
January 2019
3 Reads

State of the art: Evaluation and prognostication of myocarditis using cardiac MRI.

J Magn Reson Imaging 2019 Jan 13. Epub 2019 Jan 13.

Department of Cardiology, Barbara and Donald Zucker School of Medicine at Hofstra Northwell, Manhasset, New York, USA.

Myocarditis encompasses both primary and secondary processes causing inflammation of the myocardium. Viral infections are a common secondary cause of myocarditis with important clinical relevance. Viral myocarditis has a varied clinical presentation, potentially resulting in significant morbidity and mortality. Read More

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http://dx.doi.org/10.1002/jmri.26611DOI Listing
January 2019
3 Reads

The role of echocardiography in anomalous origin of coronary artery from pulmonary artery (ALCAPA): Simple tool for a complex diagnosis.

Echocardiography 2019 01;36(1):177-181

Cardiovascular Intervention Research Center, Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, Iran.

Anomalous origin of coronary artery from pulmonary artery (ALCAPA) is a rare coronary anomaly usually presenting in the first year of life. Adult presentation suggests a wide range of differential diagnosis such as myocarditis, dilated cardiomyopathy, and coronary artery disease. We have presented here the major distinctive echocardiographic features of ALCAPA through 4 cases. Read More

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http://doi.wiley.com/10.1111/echo.14236
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http://dx.doi.org/10.1111/echo.14236DOI Listing
January 2019
9 Reads

Fibrosis Microstructure Modulates Reentry in Non-ischemic Dilated Cardiomyopathy: Insights From Imaged Guided 2D Computational Modeling.

Front Physiol 2018 19;9:1832. Epub 2018 Dec 19.

School of Biomedical Engineering and Imaging Sciences, King's College London, London, United Kingdom.

Patients who present with non-ischemic dilated cardiomyopathy (NIDCM) and enhancement on late gadolinium magnetic resonance imaging (LGE-CMR), are at high risk of sudden cardiac death (SCD). Further risk stratification of these patients based on LGE-CMR may be improved through better understanding of fibrosis microstructure. Our aim is to examine variations in fibrosis microstructure based on LGE imaging, and quantify the effect on reentry inducibility and mechanism. Read More

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http://dx.doi.org/10.3389/fphys.2018.01832DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6305754PMC
December 2018
3 Reads

Rare Association of Mucolipidosis III alpha/beta with Dilated Cardiomyopathy.

Ann Clin Lab Sci 2018 Nov;48(6):785-789

Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea

Mucolipidosis III alpha/beta (ML III alpha/beta) is an autosomal recessive lysosomal storage disorder caused by N-acetylglucosamine-1-phosphotransferase (GlcNAc-phosphotransferase) deficiency. It is characterized by coarse facial features, developmental delay, short stature, and skeletal deformities. Its cardiovascular symptoms include valvular thickening or hypertrophic cardiomyopathy. Read More

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November 2018
12 Reads

Usefulness of Malignancy as a Predictor of WorseIn-Hospital Outcomes in Patients With Takotsubo Cardiomyopathy.

Am J Cardiol 2019 Mar 22;123(6):995-1001. Epub 2018 Dec 22.

MedStar Heart and Vascular Institute, Georgetown University, Washington, District of Columbia. Electronic address:

Takotsubo cardiomyopathy (TC) is a form of dilated cardiomyopathy often associated with physical or emotional stress. Association with cancer has been reported, however, in-hospital outcomes in TC patients with history of malignancy have not been fully characterized. We conducted a retrospective chart review of hospitalized patients with diagnosis of TC between January 2006 and January 2017. Read More

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http://dx.doi.org/10.1016/j.amjcard.2018.11.054DOI Listing
March 2019
4 Reads

Myocardial segmental thickness variability on echocardiography is a highly sensitive and specific marker to distinguish ischemic and non-ischemic dilated cardiomyopathy in new onset heart failure.

Int J Cardiovasc Imaging 2018 Dec 29. Epub 2018 Dec 29.

Division of Cardiology, UCSF Fresno, 155 N Fresno St, Fresno, CA, USA.

The aim of this study was to determine non-invasive diagnostic markers by echocardiography that differentiate ischemic dilated (ICM) from non-ischemic dilated cardiomyopathy (NICM) in patients with new onset heart failure. We identified 100 consecutive new heart failure patients with dilated cardiomyopathy (valvular etiology excluded). Clinical risk factors, medication history, serum biomarkers, ECG and echocardiographic variables were compared between the ICM and NICM groups (as confirmed by coronary angiography). Read More

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http://dx.doi.org/10.1007/s10554-018-01515-3DOI Listing
December 2018
1 Read

Comprehensive evaluation of structural and functional myocardial impairments in Becker muscular dystrophy using quantitative cardiac magnetic resonance imaging.

Eur Heart J Cardiovasc Imaging 2018 Dec 24. Epub 2018 Dec 24.

Centre de Référence de Pathologie Neuromusculaire Nord/Est/Ile-de-France, Institute of Myology, Assistance Publique des Hôpitaux de Paris, Groupe Hospitalier Pitié-Salpêtrière, 47-83 Boulevard Vincent Auriol, 75651 Paris, France.

Aims: Becker muscular dystrophy (BMD) is a genetic neuromuscular disease characterized by an alteration of the dystrophin protein. Myocardial involvement is frequent, eventually progressing to a dilated cardiomyopathy, and represents the most common cause of death for this pathology. We performed a comprehensive evaluation of myocardial functional and structural alterations encountered in a large cohort of BMD patients using quantitative cardiac magnetic resonance (CMR) imaging. Read More

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http://dx.doi.org/10.1093/ehjci/jey209DOI Listing
December 2018
5 Reads

Phenotypic Refinement of Heart Failure in a National Biobank Facilitates Genetic Discovery.

Circulation 2018 Nov 11. Epub 2018 Nov 11.

Cardiovascular Research Center, Massachusetts General Hospital, United States.

Background: Heart failure (HF) is a morbid and heritable disorder for which the biological mechanisms are incompletely understood. We therefore examined genetic associations with HF in a large national biobank, and assessed whether refined phenotypic classification would facilitate genetic discovery.

Methods: We defined all-cause HF among 488010 participants from the UK Biobank and performed a genome-wide association analysis. Read More

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http://dx.doi.org/10.1161/CIRCULATIONAHA.118.035774DOI Listing
November 2018
13 Reads

Case 38-2018: A 54-Year-Old Man with New Heart Failure.

N Engl J Med 2018 Dec;379(24):2362-2372

From the Departments of Medicine (E.M.I., A.A.S., A.E.S.), Radiology (N.M.M.), and Pathology (K.J.T.), Massachusetts General Hospital, and the Departments of Medicine (E.M.I., A.A.S., A.E.S.), Radiology (N.M.M.), and Pathology (K.J.T.), Harvard Medical School - both in Boston.

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http://dx.doi.org/10.1056/NEJMcpc1810386DOI Listing
December 2018
3 Reads

Relationship Between Electrocardiographic Findings and Cardiac Magnetic Resonance Phenotypes in Arrhythmogenic Cardiomyopathy.

J Am Heart Assoc 2018 Nov;7(22):e009855

1 Department of Cardiac, Thoracic and Vascular Sciences University of Padova Italy.

Background The new designation of arrhythmogenic cardiomyopathy defines a broader spectrum of disease phenotypes, which include right dominant, biventricular, and left dominant variants. We evaluated the relationship between electrocardiographic findings and contrast-enhanced cardiac magnetic resonance phenotypes in arrhythmogenic cardiomyopathy. Methods and Results We studied a consecutive cohort of patients with a definite diagnosis of arrhythmogenic cardiomyopathy, according to 2010 International Task Force criteria, who underwent electrocardiography and contrast-enhanced cardiac magnetic resonance. Read More

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https://www.ahajournals.org/doi/10.1161/JAHA.118.009855
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http://dx.doi.org/10.1161/JAHA.118.009855DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6404435PMC
November 2018
17 Reads

Value of Cardiac Magnetic Resonance Fractal Analysis Combined With Myocardial Strain in Discriminating Isolated Left Ventricular Noncompaction and Dilated Cardiomyopathy.

J Magn Reson Imaging 2018 Dec 19. Epub 2018 Dec 19.

Department of Radiology, Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi Province, China.

Background: Excessive trabeculation is present in isolated left ventricular noncompaction (LVNC) and dilated cardiomyopathy (DCM), which sometimes makes the differentiation between these two difficult. Fractal dimension (FD) is a unitless measure value of how completely the object fills space, which can assess the extent of myocardial trabeculae quantitatively.

Purpose: To compare the trabeculae features and myocardial strain derived from cardiac MR between LVNC and DCM. Read More

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http://doi.wiley.com/10.1002/jmri.26616
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http://dx.doi.org/10.1002/jmri.26616DOI Listing
December 2018
13 Reads

Left Ventricular Reverse Remodeling in Recent Onset Idiopathic Dilated Cardiomyopathy Using Contemporary Echo Techniques.

Isr Med Assoc J 2018 Dec;20(12):749-753

Heart Institute, Kaplan Medical Center, Rehovot, Israel.

Background: Early identification of patients with a likelihood of cardiac improvement has important implications for management strategies.

Objectives: To evaluate whether tissue Doppler imaging (TDI) and two-dimensional (2D) strain measures may predict left ventricular (LV) improvement in patients with recent onset dilated cardiomyopathy (ROCM).

Methods: Clinical and comprehensive echo were performed at baseline and at 6 months. Read More

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December 2018
1 Read

BK virus nephropathy and multiorgan involvement in a child with heart transplantation
.

Clin Nephrol 2019 Feb;91(2):107-113

BK virus is a known cause of renal failure in kidney transplant recipients, but there is little data regarding its effect on native kidneys in heart transplant patients. Here, we describe the case of a child who underwent heart transplantation and was later diagnosed with BK virus with multiorgan involvement. This patient was diagnosed with dilated cardiomyopathy at 4 months of age and underwent heart transplantation at the age of 5 years. Read More

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http://dx.doi.org/10.5414/CN109520DOI Listing
February 2019
6 Reads

Current diagnostic strategies for dilated cardiomyopathy: a comparison of imaging techniques.

Expert Rev Cardiovasc Ther 2019 Jan 26;17(1):53-63. Epub 2018 Nov 26.

a Cardiovascular Department , Università degli Studi di Trieste , Trieste , Italy.

Introduction: Dilated cardiomyopathy (DCM) is generally thought as a final common pathway of several conditions leading to the same clinical phenotype. Multiple imaging modalities play a fundamental role in recognizing the underlying pathological substrate in DCM. Areas covered: Echocardiography represents the first reliable and easily accessible diagnostic tool, allowing the identification of associated cardiac abnormalities, such as valve disease and highlighting features associated with an adverse prognosis. Read More

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https://www.tandfonline.com/doi/full/10.1080/14779072.2019.1
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http://dx.doi.org/10.1080/14779072.2019.1550719DOI Listing
January 2019
17 Reads

Plasmatic and chamber-specific modulation of cardiac microRNAs in an acute model of DOX-induced cardiotoxicity.

Biomed Pharmacother 2019 Feb 16;110:1-8. Epub 2018 Nov 16.

Immunology and Functional Genomics Unit, Centro Cardiologico Monzino IRCCS, Milan, Italy. Electronic address:

Background: Doxorubicin (DOX) is a chemotherapeutic drug limited in its usefulness by an adverse side effect, cardiotoxicity. The mechanisms leading to this detrimental occurrence are not completely clear, and lately many authors focused their attention on the possible role of microRNAs (miRNAs), small regulators of cardiovascular functions, in this phenomenon. Notably, these molecules recently emerged also as potential circulating biomarkers of several cardiac diseases. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S07533322183700
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http://dx.doi.org/10.1016/j.biopha.2018.11.042DOI Listing
February 2019
12 Reads

T1 or ECV?: Depends on the Methods.

JACC Cardiovasc Imaging 2018 Nov 8. Epub 2018 Nov 8.

Oxford Centre for Clinical Magnetic Resonance Research, Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom.

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https://linkinghub.elsevier.com/retrieve/pii/S1936878X183083
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http://dx.doi.org/10.1016/j.jcmg.2018.10.001DOI Listing
November 2018
12 Reads

Comparing CMR Mapping Methods and Myocardial Patterns Toward Heart Failure Outcomes in Nonischemic Dilated Cardiomyopathy.

JACC Cardiovasc Imaging 2018 Nov 8. Epub 2018 Nov 8.

Noninvasive Cardiovascular Imaging Program, Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts; Cardiovascular Division, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts. Electronic address:

Objectives: In patients with nonischemic dilated cardiomyopathy (NIDCM), native T1, partition coefficient (λ), and extracellular volume fraction (ECV) mapping may offer prognostic values beyond late gadolinium enhancement (LGE), by scaling the range of myocardial changes.

Background: In patients with NIDCM, LGE is seen in 30% of patients and it indicates adverse prognosis.

Methods: The study mapped 6 anatomical locations using all 4 cardiac magnetic resonance (CMR) tissue-characterizing methods and associated with outcome. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S1936878X183074
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http://dx.doi.org/10.1016/j.jcmg.2018.08.021DOI Listing
November 2018
12 Reads

Left ventricular 2D speckle tracking echocardiography for detection of systolic dysfunction in genetic, dilated cardiomyopathies.

Eur Heart J Cardiovasc Imaging 2018 Nov 15. Epub 2018 Nov 15.

Department of Cardiology, Heart Lung Center, Leiden University Medical Center, Albinusdreef 2, Leiden 2300 RC, The Netherlands.

Aims: Genetic, dilated cardiomyopathy (DCM) can be caused by a large variety of mutations. Mutation carriers are often asymptomatic until DCM is well established, presenting with heart failure, arrhythmias, or sudden cardiac death. Preventive strategies can only be applied if DCM can be detected early. Read More

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https://academic.oup.com/ehjcimaging/advance-article/doi/10.
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http://dx.doi.org/10.1093/ehjci/jey169DOI Listing
November 2018
14 Reads

Low-Gradient Aortic Stenosis: Solving the Conundrum Using Multi-Modality Imaging.

Prog Cardiovasc Dis 2018 Nov - Dec;61(5-6):416-422. Epub 2018 Nov 13.

Division of Cardiology, Mayo College of Medicine, Mayo Clinic, Rochester, MN, United States of America.

Up to 1/3 of patients with both reduced or preserved left ventricular ejection fraction (LVEF), harbor a mean pressure gradient (MPG) < 40 mm Hg (peak velocity (PV) < 4 m/s), suggesting moderate aortic stenosis (AS) and an aortic valve area (AVA) < 1 cm suggesting severe AS raising uncertainties regarding AS severity and appropriate management. In patients with reduced LVEF, increased transvalvular flow and stroke volume ≥ 20% (i.e. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00330620183022
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http://dx.doi.org/10.1016/j.pcad.2018.11.006DOI Listing
January 2019
25 Reads

Tumorous imaginal disc 1 (TID1) inhibits isoproterenol-induced cardiac hypertrophy and apoptosis by regulating c-terminus of hsc70-interacting protein (CHIP) mediated degradation of Gαs.

Int J Med Sci 2018 20;15(13):1537-1546. Epub 2018 Oct 20.

Graduate Institute of Basic Medical Science, China Medical University, Taichung, Taiwan.

Dilated cardiomyopathy (DCM) is the most common form of non-ischemic cardiomyopathy. It is characterized by ventricular chamber dilation, and myocyte hypertrophy. Human tumorous imaginal disc 1 (Tid1), a chaperone protein and response to regulate number of signaling molecules in the mitochondria or cytosol. Read More

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http://dx.doi.org/10.7150/ijms.24296DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6216068PMC
February 2019
8 Reads
2.003 Impact Factor

Current Cardiac Imaging Approaches in Duchenne Muscular Dystrophy.

J Clin Neuromuscul Dis 2018 Dec;20(2):85-93

Department of Paediatrics, Alberta Children's Hospital Research Institute, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.

Duchenne muscular dystrophy (DMD) is an X-linked neuromuscular condition caused by mutations in the dystrophin gene leading to skeletal muscle weakness and dilated cardiomyopathy. The prevalence of DMD-related cardiomyopathy increases with age and is almost universal by the third decade of life. Myocardial fibrosis and progressive left ventricular dysfunction lead to the development of heart failure and premature death. Read More

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http://Insights.ovid.com/crossref?an=00131402-201812000-0000
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http://dx.doi.org/10.1097/CND.0000000000000204DOI Listing
December 2018
25 Reads