4,553 results match your criteria Imaging in Dilated Cardiomyopathy


Relationship between left ventricular vortex and preejectional flow velocity during isovolumic contraction studied by using vector flow mapping.

Echocardiography 2019 Feb 6. Epub 2019 Feb 6.

Department of Ultrasound, PLA 967th Hospital, Dalian, China.

Objectives: The purpose of this study was to investigate the relationship between the vortex in left ventricle (LV) during the isovolumic contraction (IVC) period and the preejectional flow velocity in LV outflow tract (V ).

Methods: Color Doppler loops were acquired for vector flow mapping in apical long-axis view in 76 patients with dilated cardiomyopathy, 61 patients with coronary artery disease and 36 healthy controls.

Results: All normals exhibited an IVC vortex reaching the LV base. Read More

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http://dx.doi.org/10.1111/echo.14277DOI Listing
February 2019
1 Read

Heart rate reduction strategy using ivabradine in end-stage Duchenne cardiomyopathy.

Int J Cardiol 2019 Jan 17. Epub 2019 Jan 17.

Department of Pediatric Cardiology and Cardiac Surgery, Cardiology Unit, Bambino Gesù Hospital & Research Institute, Rome, Italy.

Background: End-stage dilated cardiomyopathy (DCM) is the leading cause of morbidity and mortality in patients with Duchenne Muscular Dystrophy (DMD). No studies are available on the effect of ivabradine on long-term outcomes in end-stage DMD/DCM.

Methods: We prospectively enrolled a cohort of end-stage DMD/DCM patients with LV ejection fraction <40%, on chronic HF treatment with an ACE inhibitor referred consecutively from 2012 to 2017 to Bambino Gesù Children's Hospital. Read More

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http://dx.doi.org/10.1016/j.ijcard.2019.01.052DOI Listing
January 2019
1 Read

Ioxynil and diethylstilbestrol disrupt vascular and heart development in zebrafish.

Environ Int 2019 Mar 25;124:511-520. Epub 2019 Jan 25.

Centre of Marine Sciences, University of Algarve, Faro, Portugal. Electronic address:

Background: Endocrine disruption is one of the consequences of industrialization and chemicals released into the environment have a profound impact on organisms. Waterborne micromolar concentrations of ioxynil (IOX) and diethylstilbestrol (DES) in fish affect the development of the heart, vasculature and thyroid gland.

Objectives: The present study aimed to determine how IOX and DES disrupt the crosstalk between the developing thyroid gland and cardio-vascular system in zebrafish. Read More

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http://dx.doi.org/10.1016/j.envint.2019.01.009DOI Listing
March 2019
2 Reads

Speckle-Tracking Echocardiography in Children With Duchenne Muscular Dystrophy: A Prospective Multicenter Controlled Cross-Sectional Study.

J Am Soc Echocardiogr 2019 Jan 21. Epub 2019 Jan 21.

PHYMEDEXP, University of Montpellier, CNRS, INSERM, CHU Montpellier, Montpellier, France.

Background: Prognosis of Duchenne muscular dystrophy (DMD) is related to cardiac dysfunction. Speckle-tracking echocardiographic (STE) imaging is emerging as a noninvasive functional biomarker to consider in the early detection of DMD-related cardiomyopathy. However, STE analysis has not been assessed in a prospectively controlled study, especially in presymptomatic children with DMD, and no study has used STE analysis in all three displacements (longitudinal, radial, and circumferential) and for both ventricles. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S08947317183060
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http://dx.doi.org/10.1016/j.echo.2018.10.017DOI Listing
January 2019
5 Reads

Long term prognostic importance of late gadolinium enhancement in first-presentation non-ischaemic dilated cardiomyopathy.

Int J Cardiol 2019 Jan 9. Epub 2019 Jan 9.

College of Medicine and Public Health, Flinders University, Australia; Department of Cardiovascular Medicine, Flinders Medical Centre, Australia; Cardiac Imaging Research Group, South Australian Health & Medical Research Institute, Australia. Electronic address:

Background: Presence of myocardial fibrosis in well-established non-ischaemic dilated cardiomyopathy (NIDCM) is associated with adverse clinical outcomes. However, the impact of myocardial fibrosis at first presentation in NIDCM, and its long-term association with left ventricular (LV) dysfunction, heart failure (HF) and ventricular arrhythmia (VA) remains unclear. We investigated whether the presence of myocardial fibrosis quantified by late gadolinium enhancement cardiovascular magnetic resonance (LGE-CMR) at presentation, is independently associated with long-term major adverse cardiovascular events (MACE) in patients with first presentation NIDCM. Read More

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http://dx.doi.org/10.1016/j.ijcard.2019.01.018DOI Listing
January 2019
1 Read

Left Ventricular Torsion - A New Echocardiographic Prognosticator in Patients With Non-Ischemic Dilated Cardiomyopathy.

Circ J 2019 Jan 20. Epub 2019 Jan 20.

Department for Internal Medicine and Cardiology, Herzzentrum Dresden, Technische Universität Dresden.

Background: Left ventricular (LV) torsion is a key parameter in cardiac function and predicts functional capacity (FC) more appropriately than LV ejection fraction (EF). We sought to investigate LV torsion as a marker of hospitalization for worsening heart failure (HF) in non-ischemic dilated cardiomyopathy (DCM) patients. Methods and Results: The 91 outpatients with newly diagnosed DCM (53±13 years, 20% female) were evaluated with 3D speckle-tracking imaging and followed up for 12 months; 43 healthy sex- and age-matched volunteers served as controls. Read More

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http://dx.doi.org/10.1253/circj.CJ-18-0986DOI Listing
January 2019
2 Reads

Microvascular Dysfunction in Dilated Cardiomyopathy: A Quantitative Stress Perfusion Cardiovascular Magnetic Resonance Study.

JACC Cardiovasc Imaging 2019 Jan 9. Epub 2019 Jan 9.

Royal Brompton Hospital, London, United Kingdom; Imperial College London, London, United Kingdom.

Objectives: This study sought to quantify myocardial blood flow (MBF) and myocardial perfusion reserve (MPR) in dilated cardiomyopathy (DCM) and examine the relationship between myocardial perfusion and adverse left ventricular (LV) remodeling.

Background: Although regarded as a nonischemic condition, DCM has been associated with microvascular dysfunction, which is postulated to play a role in its pathogenesis. However, the relationship of the resulting perfusion abnormalities to myocardial fibrosis and the degree of LV remodeling is unclear. Read More

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http://dx.doi.org/10.1016/j.jcmg.2018.10.032DOI Listing
January 2019
1 Read

Absolute Myocardial Blood Flow in Dilated Cardiomyopathy: Does it Matter?

JACC Cardiovasc Imaging 2019 Jan 9. Epub 2019 Jan 9.

Cardio-Thoracic and Vascular Department, University Hospital of Pisa, Pisa, Italy.

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http://dx.doi.org/10.1016/j.jcmg.2018.12.002DOI Listing
January 2019
1 Read

Pheochromocytoma-related cardiomyopathy presenting as broken heart syndrome: Case report and literature review.

Int J Surg Case Rep 2019 Jan 9;55:7-10. Epub 2019 Jan 9.

Department of Surgery, Kendall Regional Medical Center, Miami, FL, United States.

Introduction: Pheochromocytoma are neuroendocrine tumors that arise from sympathetic chromaffin cells within the adrenal medulla. They principally secrete catecholamines, potentially causing life-threatening cardiovascular complications. A myriad of symptomatology and clinical findings are associated with pheochromocytoma, including a catecholamine-induced dilated cardiomyopathy. Read More

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http://dx.doi.org/10.1016/j.ijscr.2018.12.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6330378PMC
January 2019
1 Read

State of the art: Evaluation and prognostication of myocarditis using cardiac MRI.

J Magn Reson Imaging 2019 Jan 13. Epub 2019 Jan 13.

Department of Cardiology, Barbara and Donald Zucker School of Medicine at Hofstra Northwell, Manhasset, New York, USA.

Myocarditis encompasses both primary and secondary processes causing inflammation of the myocardium. Viral infections are a common secondary cause of myocarditis with important clinical relevance. Viral myocarditis has a varied clinical presentation, potentially resulting in significant morbidity and mortality. Read More

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http://dx.doi.org/10.1002/jmri.26611DOI Listing
January 2019
1 Read

The role of echocardiography in anomalous origin of coronary artery from pulmonary artery (ALCAPA): Simple tool for a complex diagnosis.

Echocardiography 2019 01;36(1):177-181

Cardiovascular Intervention Research Center, Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, Iran.

Anomalous origin of coronary artery from pulmonary artery (ALCAPA) is a rare coronary anomaly usually presenting in the first year of life. Adult presentation suggests a wide range of differential diagnosis such as myocarditis, dilated cardiomyopathy, and coronary artery disease. We have presented here the major distinctive echocardiographic features of ALCAPA through 4 cases. Read More

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http://doi.wiley.com/10.1111/echo.14236
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http://dx.doi.org/10.1111/echo.14236DOI Listing
January 2019
5 Reads

Fibrosis Microstructure Modulates Reentry in Non-ischemic Dilated Cardiomyopathy: Insights From Imaged Guided 2D Computational Modeling.

Front Physiol 2018 19;9:1832. Epub 2018 Dec 19.

School of Biomedical Engineering and Imaging Sciences, King's College London, London, United Kingdom.

Patients who present with non-ischemic dilated cardiomyopathy (NIDCM) and enhancement on late gadolinium magnetic resonance imaging (LGE-CMR), are at high risk of sudden cardiac death (SCD). Further risk stratification of these patients based on LGE-CMR may be improved through better understanding of fibrosis microstructure. Our aim is to examine variations in fibrosis microstructure based on LGE imaging, and quantify the effect on reentry inducibility and mechanism. Read More

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http://dx.doi.org/10.3389/fphys.2018.01832DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6305754PMC
December 2018
1 Read

Usefulness of Malignancy as a Predictor of WorseIn-Hospital Outcomes in Patients With Takotsubo Cardiomyopathy.

Am J Cardiol 2018 Dec 22. Epub 2018 Dec 22.

MedStar Heart and Vascular Institute, Georgetown University, Washington, District of Columbia. Electronic address:

Takotsubo cardiomyopathy (TC) is a form of dilated cardiomyopathy often associated with physical or emotional stress. Association with cancer has been reported, however, in-hospital outcomes in TC patients with history of malignancy have not been fully characterized. We conducted a retrospective chart review of hospitalized patients with diagnosis of TC between January 2006 and January 2017. Read More

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http://dx.doi.org/10.1016/j.amjcard.2018.11.054DOI Listing
December 2018
1 Read

Myocardial segmental thickness variability on echocardiography is a highly sensitive and specific marker to distinguish ischemic and non-ischemic dilated cardiomyopathy in new onset heart failure.

Int J Cardiovasc Imaging 2018 Dec 29. Epub 2018 Dec 29.

Division of Cardiology, UCSF Fresno, 155 N Fresno St, Fresno, CA, USA.

The aim of this study was to determine non-invasive diagnostic markers by echocardiography that differentiate ischemic dilated (ICM) from non-ischemic dilated cardiomyopathy (NICM) in patients with new onset heart failure. We identified 100 consecutive new heart failure patients with dilated cardiomyopathy (valvular etiology excluded). Clinical risk factors, medication history, serum biomarkers, ECG and echocardiographic variables were compared between the ICM and NICM groups (as confirmed by coronary angiography). Read More

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http://dx.doi.org/10.1007/s10554-018-01515-3DOI Listing
December 2018
1 Read

Comprehensive evaluation of structural and functional myocardial impairments in Becker muscular dystrophy using quantitative cardiac magnetic resonance imaging.

Eur Heart J Cardiovasc Imaging 2018 Dec 24. Epub 2018 Dec 24.

Centre de Référence de Pathologie Neuromusculaire Nord/Est/Ile-de-France, Institute of Myology, Assistance Publique des Hôpitaux de Paris, Groupe Hospitalier Pitié-Salpêtrière, 47-83 Boulevard Vincent Auriol, 75651 Paris, France.

Aims: Becker muscular dystrophy (BMD) is a genetic neuromuscular disease characterized by an alteration of the dystrophin protein. Myocardial involvement is frequent, eventually progressing to a dilated cardiomyopathy, and represents the most common cause of death for this pathology. We performed a comprehensive evaluation of myocardial functional and structural alterations encountered in a large cohort of BMD patients using quantitative cardiac magnetic resonance (CMR) imaging. Read More

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http://dx.doi.org/10.1093/ehjci/jey209DOI Listing
December 2018
3 Reads

Phenotypic Refinement of Heart Failure in a National Biobank Facilitates Genetic Discovery.

Circulation 2018 Nov 11. Epub 2018 Nov 11.

Cardiovascular Research Center, Massachusetts General Hospital, United States.

Background: Heart failure (HF) is a morbid and heritable disorder for which the biological mechanisms are incompletely understood. We therefore examined genetic associations with HF in a large national biobank, and assessed whether refined phenotypic classification would facilitate genetic discovery.

Methods: We defined all-cause HF among 488010 participants from the UK Biobank and performed a genome-wide association analysis. Read More

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http://dx.doi.org/10.1161/CIRCULATIONAHA.118.035774DOI Listing
November 2018
7 Reads

Case 38-2018: A 54-Year-Old Man with New Heart Failure.

N Engl J Med 2018 Dec;379(24):2362-2372

From the Departments of Medicine (E.M.I., A.A.S., A.E.S.), Radiology (N.M.M.), and Pathology (K.J.T.), Massachusetts General Hospital, and the Departments of Medicine (E.M.I., A.A.S., A.E.S.), Radiology (N.M.M.), and Pathology (K.J.T.), Harvard Medical School - both in Boston.

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http://dx.doi.org/10.1056/NEJMcpc1810386DOI Listing
December 2018
1 Read

Relationship Between Electrocardiographic Findings and Cardiac Magnetic Resonance Phenotypes in Arrhythmogenic Cardiomyopathy.

J Am Heart Assoc 2018 Nov;7(22):e009855

1 Department of Cardiac, Thoracic and Vascular Sciences University of Padova Italy.

Background The new designation of arrhythmogenic cardiomyopathy defines a broader spectrum of disease phenotypes, which include right dominant, biventricular, and left dominant variants. We evaluated the relationship between electrocardiographic findings and contrast-enhanced cardiac magnetic resonance phenotypes in arrhythmogenic cardiomyopathy. Methods and Results We studied a consecutive cohort of patients with a definite diagnosis of arrhythmogenic cardiomyopathy, according to 2010 International Task Force criteria, who underwent electrocardiography and contrast-enhanced cardiac magnetic resonance. Read More

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https://www.ahajournals.org/doi/10.1161/JAHA.118.009855
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http://dx.doi.org/10.1161/JAHA.118.009855DOI Listing
November 2018
10 Reads

Value of Cardiac Magnetic Resonance Fractal Analysis Combined With Myocardial Strain in Discriminating Isolated Left Ventricular Noncompaction and Dilated Cardiomyopathy.

J Magn Reson Imaging 2018 Dec 19. Epub 2018 Dec 19.

Department of Radiology, Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi Province, China.

Background: Excessive trabeculation is present in isolated left ventricular noncompaction (LVNC) and dilated cardiomyopathy (DCM), which sometimes makes the differentiation between these two difficult. Fractal dimension (FD) is a unitless measure value of how completely the object fills space, which can assess the extent of myocardial trabeculae quantitatively.

Purpose: To compare the trabeculae features and myocardial strain derived from cardiac MR between LVNC and DCM. Read More

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http://doi.wiley.com/10.1002/jmri.26616
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http://dx.doi.org/10.1002/jmri.26616DOI Listing
December 2018
6 Reads

Left Ventricular Reverse Remodeling in Recent Onset Idiopathic Dilated Cardiomyopathy Using Contemporary Echo Techniques.

Isr Med Assoc J 2018 Dec;20(12):749-753

Heart Institute, Kaplan Medical Center, Rehovot, Israel.

Background: Early identification of patients with a likelihood of cardiac improvement has important implications for management strategies.

Objectives: To evaluate whether tissue Doppler imaging (TDI) and two-dimensional (2D) strain measures may predict left ventricular (LV) improvement in patients with recent onset dilated cardiomyopathy (ROCM).

Methods: Clinical and comprehensive echo were performed at baseline and at 6 months. Read More

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December 2018
1 Read

Current diagnostic strategies for dilated cardiomyopathy: a comparison of imaging techniques.

Expert Rev Cardiovasc Ther 2019 Jan 26;17(1):53-63. Epub 2018 Nov 26.

a Cardiovascular Department , Università degli Studi di Trieste , Trieste , Italy.

Introduction: Dilated cardiomyopathy (DCM) is generally thought as a final common pathway of several conditions leading to the same clinical phenotype. Multiple imaging modalities play a fundamental role in recognizing the underlying pathological substrate in DCM. Areas covered: Echocardiography represents the first reliable and easily accessible diagnostic tool, allowing the identification of associated cardiac abnormalities, such as valve disease and highlighting features associated with an adverse prognosis. Read More

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https://www.tandfonline.com/doi/full/10.1080/14779072.2019.1
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http://dx.doi.org/10.1080/14779072.2019.1550719DOI Listing
January 2019
12 Reads

Plasmatic and chamber-specific modulation of cardiac microRNAs in an acute model of DOX-induced cardiotoxicity.

Biomed Pharmacother 2019 Feb 16;110:1-8. Epub 2018 Nov 16.

Immunology and Functional Genomics Unit, Centro Cardiologico Monzino IRCCS, Milan, Italy. Electronic address:

Background: Doxorubicin (DOX) is a chemotherapeutic drug limited in its usefulness by an adverse side effect, cardiotoxicity. The mechanisms leading to this detrimental occurrence are not completely clear, and lately many authors focused their attention on the possible role of microRNAs (miRNAs), small regulators of cardiovascular functions, in this phenomenon. Notably, these molecules recently emerged also as potential circulating biomarkers of several cardiac diseases. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S07533322183700
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http://dx.doi.org/10.1016/j.biopha.2018.11.042DOI Listing
February 2019
11 Reads

T1 or ECV?: Depends on the Methods.

JACC Cardiovasc Imaging 2018 Nov 8. Epub 2018 Nov 8.

Oxford Centre for Clinical Magnetic Resonance Research, Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom.

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https://linkinghub.elsevier.com/retrieve/pii/S1936878X183083
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http://dx.doi.org/10.1016/j.jcmg.2018.10.001DOI Listing
November 2018
7 Reads

Comparing CMR Mapping Methods and Myocardial Patterns Toward Heart Failure Outcomes in Nonischemic Dilated Cardiomyopathy.

JACC Cardiovasc Imaging 2018 Nov 8. Epub 2018 Nov 8.

Noninvasive Cardiovascular Imaging Program, Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts; Cardiovascular Division, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts. Electronic address:

Objectives: In patients with nonischemic dilated cardiomyopathy (NIDCM), native T1, partition coefficient (λ), and extracellular volume fraction (ECV) mapping may offer prognostic values beyond late gadolinium enhancement (LGE), by scaling the range of myocardial changes.

Background: In patients with NIDCM, LGE is seen in 30% of patients and it indicates adverse prognosis.

Methods: The study mapped 6 anatomical locations using all 4 cardiac magnetic resonance (CMR) tissue-characterizing methods and associated with outcome. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S1936878X183074
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http://dx.doi.org/10.1016/j.jcmg.2018.08.021DOI Listing
November 2018
6 Reads

Left ventricular 2D speckle tracking echocardiography for detection of systolic dysfunction in genetic, dilated cardiomyopathies.

Eur Heart J Cardiovasc Imaging 2018 Nov 15. Epub 2018 Nov 15.

Department of Cardiology, Heart Lung Center, Leiden University Medical Center, Albinusdreef 2, Leiden 2300 RC, The Netherlands.

Aims: Genetic, dilated cardiomyopathy (DCM) can be caused by a large variety of mutations. Mutation carriers are often asymptomatic until DCM is well established, presenting with heart failure, arrhythmias, or sudden cardiac death. Preventive strategies can only be applied if DCM can be detected early. Read More

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https://academic.oup.com/ehjcimaging/advance-article/doi/10.
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http://dx.doi.org/10.1093/ehjci/jey169DOI Listing
November 2018
12 Reads

Low-Gradient Aortic Stenosis: Solving the Conundrum Using Multi-Modality Imaging.

Prog Cardiovasc Dis 2018 Nov - Dec;61(5-6):416-422. Epub 2018 Nov 13.

Division of Cardiology, Mayo College of Medicine, Mayo Clinic, Rochester, MN, United States of America.

Up to 1/3 of patients with both reduced or preserved left ventricular ejection fraction (LVEF), harbor a mean pressure gradient (MPG) < 40 mm Hg (peak velocity (PV) < 4 m/s), suggesting moderate aortic stenosis (AS) and an aortic valve area (AVA) < 1 cm suggesting severe AS raising uncertainties regarding AS severity and appropriate management. In patients with reduced LVEF, increased transvalvular flow and stroke volume ≥ 20% (i.e. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00330620183022
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http://dx.doi.org/10.1016/j.pcad.2018.11.006DOI Listing
January 2019
15 Reads

Tumorous imaginal disc 1 (TID1) inhibits isoproterenol-induced cardiac hypertrophy and apoptosis by regulating c-terminus of hsc70-interacting protein (CHIP) mediated degradation of Gαs.

Int J Med Sci 2018 20;15(13):1537-1546. Epub 2018 Oct 20.

Graduate Institute of Basic Medical Science, China Medical University, Taichung, Taiwan.

Dilated cardiomyopathy (DCM) is the most common form of non-ischemic cardiomyopathy. It is characterized by ventricular chamber dilation, and myocyte hypertrophy. Human tumorous imaginal disc 1 (Tid1), a chaperone protein and response to regulate number of signaling molecules in the mitochondria or cytosol. Read More

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http://dx.doi.org/10.7150/ijms.24296DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6216068PMC
October 2018
1 Read
2.003 Impact Factor

Current Cardiac Imaging Approaches in Duchenne Muscular Dystrophy.

J Clin Neuromuscul Dis 2018 Dec;20(2):85-93

Department of Paediatrics, Alberta Children's Hospital Research Institute, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.

Duchenne muscular dystrophy (DMD) is an X-linked neuromuscular condition caused by mutations in the dystrophin gene leading to skeletal muscle weakness and dilated cardiomyopathy. The prevalence of DMD-related cardiomyopathy increases with age and is almost universal by the third decade of life. Myocardial fibrosis and progressive left ventricular dysfunction lead to the development of heart failure and premature death. Read More

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http://Insights.ovid.com/crossref?an=00131402-201812000-0000
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http://dx.doi.org/10.1097/CND.0000000000000204DOI Listing
December 2018
15 Reads

Prenatal hypocalvaria after prolonged intrauterine exposure to angiotensin II receptor antagonists.

J Renin Angiotensin Aldosterone Syst 2018 Oct-Dec;19(4):1470320318810940

1 Obstetrics and Gynaecology Department, Besançon University Medical Centre, Franche-Comté University, France.

We report a case of prenatal exposure to angiotensin II receptor antagonists (ARA II) from the beginning of pregnancy in a patient with a hypokinetic dilated cardiomyopathy. This case report emphasizes the fetal renal impact of prolonged intrauterine exposure to renin-angiotensin system (RAS) blockers, and highlights that this exposure can cause severe prenatal hypocalvaria. This delayed ossification can be reversible after birth, but the presence of anhydramnios indicates an early and irreversible block of RAS blockers in the fetus that is responsible for fetal kidney development abnormalities. Read More

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http://dx.doi.org/10.1177/1470320318810940DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6243420PMC
January 2019
11 Reads

Quantitative evaluation of non-ischemic dilated cardiomyopathy by late iodine enhancement using rapid kV switching dual-energy computed tomography: A feasibility study.

J Cardiovasc Comput Tomogr 2018 Oct 29. Epub 2018 Oct 29.

Division of Radiology, Department of Pathophysiological Therapeutic Science, Tottori University Faculty of Medicine, Yonago City, Tottori 683-8504, Japan.

Objectives: The aim of this study was to evaluate the feasibility of myocardial iodine density and extracellular volume fraction (ECV) from delayed iodine density images using dual-energy computed tomography (DECT) for differentiation between non-ischemic dilated cardiomyopathy (NIDCM) patients and normal subjects.

Methods: Forty-six subjects were imaged, including 35 normal subjects and 11 patients with NIDCM. All subjects underwent myocardial delayed enhancement (MDE) imaging on rapid-kVp switching DECT. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S19345925183044
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http://dx.doi.org/10.1016/j.jcct.2018.10.028DOI Listing
October 2018
5 Reads

Prognostic value of left-ventricular systolic and diastolic dyssynchrony measured from gated SPECT MPI in patients with dilated cardiomyopathy.

J Nucl Cardiol 2018 Nov 1. Epub 2018 Nov 1.

School of Computing, University of Southern Mississippi, 730 East Beach Blvd, Long Beach, MS, 39560, USA.

Background: Left-ventricular systolic dyssynchrony (LVSD) has been an important prognostic factor in the patients with dilated cardiomyopathy (DCM). However, the association between the LV diastolic dyssynchrony (LVDD) and clinical outcome is not well established. This study aims to evaluate the prognostic values of both systolic and diastolic dyssynchrony in patients with DCM. Read More

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http://link.springer.com/10.1007/s12350-018-01468-z
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http://dx.doi.org/10.1007/s12350-018-01468-zDOI Listing
November 2018
3 Reads

Towards cardiac MRI based risk stratification in idiopathic dilated cardiomyopathy.

Heart 2018 Oct 30. Epub 2018 Oct 30.

Cardiac MRI Department, North West Heart Centre, Manchester University Foundation Trust-Wythenshawe Site, Manchester, UK.

Sudden cardiac death (SCD) secondary to arrhythmia remains a risk in those with dilated cardiomyopathy (DCM), an implantable cardiac defibrillator (ICD) is an effective strategy to prevent SCD. Current guidelines recommend selection for ICD based on ejection fraction (EF) less than 35%, however, most SCD occurs in those with EF>35%. Although meta-analysis has demonstrated a survival benefit for primary prevention ICD in DCM, no randomised trial has shown a significant reduction in overall mortality including the most recent 'Danish Study to Assess the Efficacy of ICDs in Patients With Non-Ischemic Systolic Heat Failure on Mortality' study. Read More

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http://heart.bmj.com/lookup/doi/10.1136/heartjnl-2018-313767
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http://dx.doi.org/10.1136/heartjnl-2018-313767DOI Listing
October 2018
9 Reads

Myocardial work by echocardiography: a novel method ready for clinical testing.

Eur Heart J Cardiovasc Imaging 2019 01;20(1):18-20

Institute for Surgical Research, University of Oslo, Center for Cardiological Innovation; and Department of Cardiology, Oslo University Hospital, Rikshospitalet, Oslo, Norway.

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https://academic.oup.com/ehjcimaging/advance-article/doi/10.
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http://dx.doi.org/10.1093/ehjci/jey156DOI Listing
January 2019
18 Reads

Peripartum cardiomyopathy and ventricular thrombus: A case report and review of literature.

North Clin Istanb 2018 30;5(2):145-147. Epub 2018 Mar 30.

Department of Cardiology, Atatürk University Faculty of Medicine, Erzurum, Turkey.

Peripartum cardiomyopathy (PPCMP) is a rare and life-threatening condition. Intracardiac thrombus is characteristically associated with increased adverse events, mortality, and a high risk of thromboembolic events, and has been associated with PPCMP. Early diagnosis and treatment play a critical role. Read More

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http://kuzeyklinikleri.com/jvi.aspx?pdir=nci&plng=tur&am
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http://dx.doi.org/10.14744/nci.2017.53254DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6191556PMC
March 2018
8 Reads

High-Risk Cardiovascular Conditions in Sports-Related Sudden Death: Prevalence in 5,169 Schoolchildren Screened via Cardiac Magnetic Resonance.

Tex Heart Inst J 2018 08 1;45(4):205-213. Epub 2018 Aug 1.

Improving preparticipation screening of candidates for sports necessitates establishing the prevalence of high-risk cardiovascular conditions (hr-CVC) that predispose young people to sudden cardiac death (SCD). Our accurate, novel protocol chiefly involved the use of cardiac magnetic resonance (CMR) to estimate this prevalence. Middle and high school students from a general United States population were screened by means of questionnaires, resting electrocardiograms, and CMR to determine the prevalence of 3 types of hr-CVC: electrocardiographic abnormalities, cardiomyopathies, and anomalous coronary artery origin from the opposite sinus with intramural coronary course (ACAOS-IM). Read More

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http://thij.org/doi/10.14503/THIJ-18-6645
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http://dx.doi.org/10.14503/THIJ-18-6645DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6183627PMC
August 2018
13 Reads

INCA (Peru) Study: Impact of Non-Invasive Cardiac Magnetic Resonance Assessment in the Developing World.

J Am Heart Assoc 2018 Sep;7(17):e008981

1 Cardiac Imaging Barts Heart Centre St. Bartholomew's Hospital London London United Kingdom.

Background Advanced cardiac imaging permits optimal targeting of cardiac treatment but needs to be faster, cheaper, and easier for global delivery. We aimed to pilot rapid cardiac magnetic resonance ( CMR ) with contrast in a developing nation, embedding it within clinical care along with training and mentoring. Methods and Results A cross-sectional study of CMR delivery and clinical impact assessment performed 2016-2017 in an upper middle-income country. Read More

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https://www.ahajournals.org/doi/10.1161/JAHA.118.008981
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http://dx.doi.org/10.1161/JAHA.118.008981DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6201420PMC
September 2018
8 Reads

A-Band Titin Truncation in Zebrafish Causes Dilated Cardiomyopathy and Hemodynamic Stress Intolerance.

Circ Genom Precis Med 2018 Aug;11(8):e002135

Molecular Cardiology and Biophysics Division (I.G.H., L.W.W., C.F.S., C.H., R.J., T.J.B., G.T., D.F.).

Background Truncating variants in the TTN gene ( TTNtv) are common in patients with dilated cardiomyopathy (DCM) but also occur in the general population. Whether TTNtv are sufficient to cause DCM or require a second hit for DCM manifestation is an important clinical issue. Methods We generated a zebrafish model of an A-band TTNtv identified in 2 human DCM families in which early-onset disease appeared to be precipitated by ventricular volume overload. Read More

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https://www.ahajournals.org/doi/10.1161/CIRCGEN.118.002135
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http://dx.doi.org/10.1161/CIRCGEN.118.002135DOI Listing
August 2018
13 Reads

Smoking aggravates ventricular arrhythmic events in non-ischemic dilated cardiomyopathy associated with a late gadolinium enhancement in cardiac MRI.

Sci Rep 2018 Oct 23;8(1):15609. Epub 2018 Oct 23.

Department of Cardiology, Internal medicine, Yonsei University Health System, Seoul, Korea.

Smoking is known to increase cardiovascular events, but the association and mechanisms between smoking and ventricular arrhythmic events in dilated cardiomyopathy (DCMP) are unknown. The purpose of this study is to investigate the hypothesis that smoking is associated with sudden cardiac death (SCD) and ventricular arrhythmia in DCMP patients. We enrolled 378 patients who underwent cardiovascular magnetic resonance imaging (cMRI) and were diagnosed with DCMP at two general hospitals in Korea. Read More

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http://dx.doi.org/10.1038/s41598-018-34145-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6199322PMC
October 2018
1 Read
5.080 Impact Factor

Usefulness of Focused Screening Echocardiography for Collegiate Athletes.

Am J Cardiol 2019 Jan 26;123(1):169-174. Epub 2018 Sep 26.

Division of Cardiovascular Medicine, Department of Medicine, University of Wisconsin, School of Medicine and Public Health, Madison, Wisconsin. Electronic address:

Sudden cardiac death in a young healthy athlete is a rare but catastrophic event. The American Heart Association preparticipation screening guidelines recommend a focused history and physical without routine imaging or electrocardiogram screening. We hypothesized that a focused echocardiogram can identify structural abnormalities that may lead to sudden cardiac death in athletes, which might otherwise go undetected by history and physical. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00029149183183
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http://dx.doi.org/10.1016/j.amjcard.2018.09.012DOI Listing
January 2019
7 Reads

Arrhythmogenic right ventricular dysplasia, cutaneous manifestations and desmoplakin mutation: Carvajal syndrome.

Pediatr Int 2018 Oct;60(10):987-989

Department of Pediatric Cardiology and Pediatric Dermatology, Marmara University Faculty of Medicine, Istanbul, Turkey.

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http://dx.doi.org/10.1111/ped.13683DOI Listing
October 2018
13 Reads

An unusual presentation of anomalous left coronary artery from the pulmonary artery (ALCAPA) syndrome in a 70-year-old man: a case report.

J Med Case Rep 2018 Oct 22;12(1):308. Epub 2018 Oct 22.

Department of Morphology, Surgery and Experimental Medicine, Section of Radiology, University of Ferrara, Via Ludovico Ariosto 35, 44121, Ferrara, Italy.

Background: We present a rare case of anomalous origin of the left coronary artery from the pulmonary artery syndrome in an elderly man, and we describe coronary computed tomographic angiographic imaging findings to improve diagnostic confidence for the evaluation of this uncommon coronary artery anomaly.

Case Presentation: A 70-year-old Caucasian man came to our hospital with slight limitation of physical activity (New York Heart Association class II). He was asymptomatic for angina, syncope, and palpitations. Read More

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https://jmedicalcasereports.biomedcentral.com/articles/10.11
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http://dx.doi.org/10.1186/s13256-018-1851-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6196447PMC
October 2018
10 Reads

Left atrial longitudinal strain in dilated cardiomyopathy patients: is there a discrimination threshold for atrial fibrillation?

Int J Cardiovasc Imaging 2018 Oct 19. Epub 2018 Oct 19.

Faculty of Medicine and Health Sciences, Jan Kochanowski University, Kielce, Poland.

To determine the left atrial longitudinal strain discrimination threshold of atrial fibrillation (AF) in patients with dilated cardiomyopathy (DCM). A total of 100 DCM patients and LVEF < 25% were included. Of them, 50 had sinus rhythm (SR), and 50 had AF. Read More

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http://dx.doi.org/10.1007/s10554-018-1466-2DOI Listing
October 2018
2 Reads

Epicardial adipose tissue volume in patients with coronary artery disease or non-ischaemic dilated cardiomyopathy: evaluation with cardiac magnetic resonance imaging.

Clin Radiol 2019 Jan 15;74(1):81.e1-81.e7. Epub 2018 Oct 15.

Unit of Radiology, IRCCS Policlinico San Donato, Via Morandi 30, 20097, San Donato Milanese, Milan, Italy; Department of Biomedical Sciences for Health, Università degli Studi di Milano, Via Morandi 30, 20097, San Donato Milanese, Milan, Italy.

Aim: To compare the amount of epicardial adipose tissue (EAT) in patients with coronary artery disease (CAD) or non-ischaemic dilated cardiomyopathy (NIDCM) with that in patients with negative cardiac magnetic resonance imaging (CMR).

Materials And Methods: One hundred and fifty patients (median age 57 years, interquartile range [IQR] 46-66 years) who underwent CMR were evaluated retrospectively: 50 with CAD, 50 with NIDCM, and 50 with negative CMR. For each patient, the EAT mass index (EATMI) to body surface area, end-diastolic volume index (EDVI), end-systolic volume index (ESVI), stroke volume (SV), ejection fraction (EF) for both ventricles, and left ventricle (LV) mass index were estimated. Read More

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http://dx.doi.org/10.1016/j.crad.2018.09.006DOI Listing
January 2019
2 Reads

Strain Values of Left Ventricular Segments Reduce Non-homogeneously in Dilated Cardiomyopathy with Moderately and Severely Deteriorated Heart Function Assessed by MRI Tissue Tracking Imaging.

Int Heart J 2018 Nov 10;59(6):1312-1319. Epub 2018 Oct 10.

Department of Cardiology, Shanghai Jiao Tong University Affiliated Sixth People's Hospital.

Changes of global and segmental ventricular strain at different deterioration levels of cardiac function in patients with dilated cardiomyopathy (DCM) using cardiac magnetic resonance (CMR) have not yet been explored. In total, 101 patients diagnosed with DCM consecutively underwent CMR. They were categorized according to the reduction in left ventricular ejection fraction (LVEF) into the following groups: moderately reduced (n = 43) and severely reduced group (n = 58). Read More

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https://www.jstage.jst.go.jp/article/ihj/advpub/0/advpub_17-
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http://dx.doi.org/10.1536/ihj.17-558DOI Listing
November 2018
3 Reads

Preoperative CT of cardiac veins for planning left ventricular lead placement in cardiac resynchronization therapy.

Acta Radiol 2018 Oct 10:284185118803796. Epub 2018 Oct 10.

2 Department of Clinical Sciences, Arrhythmia Section, Lund University, Skane University Hospital, Lund, Sweden.

Background Successful cardiac resynchronization therapy (CRT) requires appropriate left ventricular (LV) lead placement on a suitable segment of the free LV wall. Current guidelines suggest targeted lead placement, but the individual anatomy of the cardiac veins is often a limiting factor. Purpose To map cardiac veins with multidetector computed tomography (MDCT) and plot the veins in cardiac segments to facilitate successful CRT implantation. Read More

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http://journals.sagepub.com/doi/10.1177/0284185118803796
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http://dx.doi.org/10.1177/0284185118803796DOI Listing
October 2018
4 Reads
1.350 Impact Factor

Timing of Left Ventricular Remodeling in Nonischemic Dilated Cardiomyopathy.

Am J Med Sci 2018 Sep 8;356(3):262-267. Epub 2018 Jun 8.

Division of Cardiovascular Medicine and. Electronic address:

Background: Mineralocorticoid receptor antagonist (MRA) treatment produces beneficial left ventricular (LV) remodeling in nonischemic dilated cardiomyopathy (NIDCM). This study addressed the timing of maximal beneficial LV remodeling in NIDCM when adding MRA.

Materials And Methods: We studied 12 patients with NIDCM on stable β-blocker and angiotensin-converting enzyme inhibitor/angiotensin receptor-blocking therapy who underwent cardiac magnetic resonance imaging before and after 6-31 months of continuous MRA therapy. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00029629183021
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http://dx.doi.org/10.1016/j.amjms.2018.06.003DOI Listing
September 2018
2 Reads

Narrowing of the QRS complex, elimination of late gadolinium enhancement and remarkable reverse remodeling achieved by optimal medical treatment in non-ischemic dilated cardiomyopathy.

J Cardiol Cases 2018 Feb 26;17(2):59-62. Epub 2017 Oct 26.

Department of Cardiology and Nephrology, Mie University Graduate School of Medicine, Tsu, Japan.

A 67-year-old woman presented with exertional dyspnea. An electrocardiogram showed complete left bundle branch block. Cardiac magnetic resonance imaging revealed left ventricular (LV) dilatation with reduced ejection fraction, no evidence of myocardial ischemia and late gadolinium enhancement (LGE) in the inferior LV wall. Read More

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http://dx.doi.org/10.1016/j.jccase.2017.09.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6149558PMC
February 2018
1 Read

Circulating markers of collagen types I, III, and IV in patients with dilated cardiomyopathy: relationships with myocardial collagen expression.

ESC Heart Fail 2018 12 1;5(6):1044-1051. Epub 2018 Oct 1.

Department of Cardiovascular Center, Osaka Red Cross Hospital, Osaka, Japan.

Aims: Collagen-derived peptides such as collagen I C-terminal telopeptide (CITP) and procollagen III N-terminal propeptide (PIIINP) have been conventionally used as markers of cardiac fibrosis. Collagen IV 7S domain (P4NP 7S) has been recently reported to be correlated with haemodynamics in patients with acute heart failure. We investigated whether these markers reflect cardiac remodelling and myocardial collagen expression. Read More

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http://dx.doi.org/10.1002/ehf2.12360DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6301156PMC
December 2018
3 Reads

Uhl's anomaly: rare but does exist.

Asian Cardiovasc Thorac Ann 2018 Sep 9;26(7):563-565. Epub 2016 Oct 9.

3 Department of Pediatric Cardiology, Fortis Hospital, Jaipur, India.

A 17-year-old boy presented with facial puffiness and swelling in the lower limbs for 6 months and one episode of syncope 15 days earlier. Transthoracic echocardiography showed a dilated right atrium and right ventricle with right ventricular systolic dysfunction. The free wall of the right ventricle was thinned out and devoid of myocardium and trabeculations. Read More

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http://dx.doi.org/10.1177/0218492316674859DOI Listing
September 2018
9 Reads

A new approach to assess myocardial work by non-invasive left ventricular pressure-strain relations in hypertension and dilated cardiomyopathy.

Eur Heart J Cardiovasc Imaging 2019 01;20(1):31-39

Department of Cardiology, The Prince Charles Hospital, Rode Road, Brisbane, Queensland, Australia.

Aims: Non-invasive left ventricular (LV) pressure-strain loop (PSL) provides a novel method of quantifying myocardial work (MW) with potential advantages over conventional global longitudinal strain (GLS) by incorporating measurements of myocardial deformation and LV pressure. We investigated different patterns of LV PSL and global MW index (GWI) in patients with hypertension (HTN) and dilated cardiomyopathy (CMP).

Methods And Results: Seventy-four patients underwent transthoracic echocardiography and strain analysis before coronary angiography. Read More

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http://dx.doi.org/10.1093/ehjci/jey131DOI Listing
January 2019
7 Reads