4,629 results match your criteria Imaging in Crohn Disease


Abdominal ultrasonography with color Doppler analysis in the assessment of ileal Crohn's disease: comparison with magnetic resonance enterography.

Intest Res 2019 Apr 10. Epub 2019 Apr 10.

Serviço de Gastroenterologia, Departamento de Clínica Médica, Hospital Universitário Clementino Fraga Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.

Background/aims: Consistently defining disease activity remains a critical challenge in the follow-up of patients with Crohn's disease (CD). We investigated the potential applicability of abdominal ultrasonography with color Doppler (USCD) analysis for the detection of morphological alterations and inflammatory activity in CD.

Methods: Forty-three patients with CD ileitis/ileocolitis were evaluated using USCD analysis with measurements obtained on the terminal ileum and right colon. Read More

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http://dx.doi.org/10.5217/ir.2018.00124DOI Listing
April 2019
1 Read

Hepatobiliary and pancreatic manifestations in inflammatory bowel diseases: a referral center study.

BMC Gastroenterol 2019 Apr 3;19(1):48. Epub 2019 Apr 3.

Department of Gastroenterology and Hepatology, Medical school and University of Ioannina, Ioannina, Greece.

Background: Hepatobiliary and pancreatic manifestations have been reported in patients with Crohn's disease or ulcerative colitis. Our aim was to describe the prevalence of hepatobiliary and pancreatic manifestations in inflammatory bowel disease and their association with the disease itself and the medications used.

Methods: Data were retrospectively extracted from the clinical records of patients followed up at our tertiary IBD referral Center. Read More

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http://dx.doi.org/10.1186/s12876-019-0967-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6446300PMC
April 2019
2 Reads

Usefulness of Strain Elastography, ARFI Imaging, and Point Shear Wave Elastography for the Assessment of Crohn Disease Strictures.

J Ultrasound Med 2019 Mar 28. Epub 2019 Mar 28.

Department of Medical Ultrasound, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China.

Objectives: The aim of this study was to evaluate the diagnostic performance of strain elastography, acoustic radiation force impulse (ARFI) imaging and point shear wave elastography (p-SWE) for assessment of the predominant types of intestinal stenosis in Crohn disease.

Methods: Twenty-five patients were enrolled in this study, among whom 25 suspicious stenoses in 25 intestinal segments were studied using gray scale ultrasonography. All 3 elastography methods were performed, and all patients underwent endoscopy within 24 hours with pathologic biopsy. Read More

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http://dx.doi.org/10.1002/jum.14989DOI Listing
March 2019
1 Read

European Society of Paediatric Radiology abdominal imaging task force: statement on imaging in very early onset inflammatory bowel disease.

Pediatr Radiol 2019 Mar 27. Epub 2019 Mar 27.

Department of Radiology and Nuclear Medicine, Unit for Paediatric Radiology, Oslo University Hospital, Oslo, Norway.

Very early onset inflammatory bowel disease (VEO-IBD) is defined as disease presenting before the age of 6. These children require a tailored imaging approach because conventional imaging studies can be difficult to perform at such a young age. Unlike inflammatory bowel disease in older children and adults, colonic disease predominates in VEO-IBD, and small-bowel disease is rare. Read More

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http://dx.doi.org/10.1007/s00247-019-04375-8DOI Listing

MR Imaging Evaluation of Inflammatory Bowel Disease in Children:: Where Are We Now in 2019.

Magn Reson Imaging Clin N Am 2019 May 14;27(2):291-300. Epub 2019 Feb 14.

Division of Thoracic Imaging, Department of Radiology, Children's Hospital Boston, Harvard Medical School, 330 Longwood Avenue, Boston, MA 02115, USA; Department of Medicine, Pulmonary Division, Children's Hospital Boston, Harvard Medical School, 330 Longwood Avenue, Boston, MA 02115, USA.

Inflammatory bowel disease (IBD) is an important cause of abdominal pain in the pediatric population. Magnetic resonance enterography (MRE) plays a crucial role in assessment of disease severity, location, extent of disease, and assessment for associated complications. As MR imaging technology has advanced, new techniques have been brought into clinical practice. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10649689193000
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http://dx.doi.org/10.1016/j.mric.2019.01.007DOI Listing
May 2019
7 Reads

Comparison of three oral contrast preparations for magnetic resonance enterography in pediatric patients with known or suspected Crohn disease: a prospective randomized trial.

Pediatr Radiol 2019 Mar 9. Epub 2019 Mar 9.

Department of Radiology, Massachusetts General Hospital, 55 Fruit St., Boston, MA, 02114, USA.

Background: Oral contrast preparation is fundamental to ensuring diagnostic examination quality for magnetic resonance enterography (MRE), yet little is known about the relative palatability and tolerability of various oral contrast agents in pediatric patients with known or suspected inflammatory bowel disease.

Objective: We prospectively compared three MRE oral preparations in pediatric patients with known or suspected Crohn disease with respect to patient-reported tolerability and radiologist-determined small-bowel distension and opacification.

Materials And Methods: Seventy-five pediatric patients (mean age 14. Read More

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http://dx.doi.org/10.1007/s00247-019-04378-5DOI Listing
March 2019
3 Reads

Ultrasonographic assessment of Crohn's disease patients: can be easier and more affordable for clinical practice?

J Gastrointestin Liver Dis 2019 03;28(1):130-131

Center of Gastroenterology and Hepatology, Fundeni Clinic Institute, University of Medicine "Carol-Davila", Bucharest, Romania.

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http://dx.doi.org/10.15403/jgld.2014.1121.281.crhDOI Listing
March 2019
1 Read

[Value of magnetic resonance diffusion-weighted imaging for evaluating the inflammatory activity of perianal Crohn's fistula].

Zhong Nan Da Xue Xue Bao Yi Xue Ban 2019 Feb;44(2):173-179

Department of Radiology, Jiangsu Cancer Hospital, Nanjing 210029, China.

Objective: To explore the value of magnetic resonance diffusion-weighted imaging (MR-DWI) for evaluating inflammatory activity of perianal Crohn's fistula.
 Methods: A total of 55 patients, who were diagnosed as perianal Crohn's fistula by surgery and/or endoscopy, were assessed retrospectively. All patients, underwent pelvic magnetic resonance imaging (MRI) before and 32 weeks after the treatment, were divided into 2 groups according to their response to treatment: an effective group (34 cases) and an ineffective group (21 cases). Read More

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http://dx.doi.org/10.11817/j.issn.1672-7347.2019.02.009DOI Listing
February 2019
1 Read

[The role of fecal calprotectin in the diagnosis and treatment of gastrointestinal diseases].

Orv Hetil 2019 Mar;160(9):322-328

I. Belgyógyászati Klinika, Semmelweis Egyetem, Általános Orvostudományi Kar Budapest, Korányi Sándor u. 2/a, 1083.

The diagnostics of gastrointestinal diseases have evolved significantly in the past few decades. Besides endoscopy and conventional imaging modalities, there is a growing interest for rapid point-of-care laboratory tests to help discriminate between diseases with similar clinical symptoms and/or help the follow-up of chronic conditions, predicting relapses. The fecal calprotectin testing is a routine diagnostic tool in many countries. Read More

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https://www.akademiai.com/doi/10.1556/650.2019.31289
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http://dx.doi.org/10.1556/650.2019.31289DOI Listing
March 2019
10 Reads

Efficacy of Injection of Freshly Collected Autologous Adipose Tissue Into Perianal Fistulas in Patients With Crohn's Disease.

Gastroenterology 2019 Feb 14. Epub 2019 Feb 14.

Department of Surgery, Pelvic Floor Unit, Aarhus University Hospital, Aarhus, Denmark.

Background And Aims: Perianal fistulas are common in patients with Crohn´s disease (CD). Injections of cultured autologous and allogeneic adipose tissue-derived stem cells have been shown to heal CD-associated fistulas. Unfortunately, this treatment is time-consuming and expensive. Read More

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http://dx.doi.org/10.1053/j.gastro.2019.02.005DOI Listing
February 2019
1 Read

Acute abdominal pain in patients with Crohn's disease: what urgent imaging tests should be done?

Radiologia 2019 Feb 13. Epub 2019 Feb 13.

Servicio de Radiología, Hospital Universitario Ramón y Cajal, Madrid, España.

Crohn's disease is an autoimmune disease that predominantly affects the gastrointestinal tract. Crohn's disease is diagnosed at a young age and runs a chronic course with acute flare-ups. When patients with Crohn's disease present with flare-ups at the emergency department, they are usually managed in a way similar to patients with acute abdomen; there is no consensus about the most appropriate imaging work-up for patients with flare-ups of Crohn's disease. Read More

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http://dx.doi.org/10.1016/j.rx.2018.12.003DOI Listing
February 2019
1 Read

A Validated Score Assessing the Risk for an Intra-Abdominal Abscess in Patients with Crohn's Disease Presenting at the Emergency Department.

J Crohns Colitis 2019 Feb 14. Epub 2019 Feb 14.

Institute of Gastroenterology and Liver Diseases, Department of Medicine, Hadassah - Hebrew University Medical Center, Jerusalem, Israel.

Background And Aims: A majority of acutely-ill Crohn's disease (CD) patients who present to Emergency Department (ED) will undergo an abdominal CT to rule out disease complications. We aimed to generate a simple non-invasive scoring model to predict the presence of an intra-abdominal abscess in CD patients in the ED.

Methods: We performed a retrospective case control study at four Israeli hospitals from January-1 st-2010 to May-30 th-2018. Read More

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http://dx.doi.org/10.1093/ecco-jcc/jjz043DOI Listing
February 2019
1 Read

ANALYSIS OF THE CLINICAL CHARACTERISTICS OF PERIANAL FISTULISING CROHN'S DISEASE IN A SINGLE CENTER.

Arq Bras Cir Dig 2019 Feb 7;32(1):e1420. Epub 2019 Feb 7.

The First Clinical Medical College, Nanjing University of Chinese Medicine, Nanjing, Jiangsu, China.

Background: Clinical characteristics are keys to improve identification and treatment of Crohn´s disease (CD) so that large sample analysis is of great value.

Aim: To explore the clinical characteristics of perianal fistulising CD.

Methods: Analysis of 139 cases focused on their clinical data. Read More

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http://dx.doi.org/10.1590/0102-672020180001e1420DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6368168PMC
February 2019
2 Reads

MRI reveals different Crohn's disease phenotypes in children and adults.

Eur Radiol 2019 Feb 7. Epub 2019 Feb 7.

Department of Pediatrics and Pediatric Neuropsychiatry, Sapienza University of Rome, Policlinico Umberto I Hospital, Viale del Policlinico, 155, 00161, Rome, Italy.

Objectives: To identify differences between two cohorts of adult and pediatric patients affected by Crohn's disease (CD), with regard to lesion location in the small intestine and colon-rectum, lesion activity, and prevalence of perianal disease (PD), using MRI as the main diagnostic tool.

Methods: We retrospectively reviewed 350 consecutive MRI examinations performed between 2013 and 2016 in outpatients or inpatients with histologically proven CD, monitored by the Gastroenterology and Pediatric Units of our Hospital. The magnetic resonance enterography (MRE) protocol for adult and pediatric CD patients routinely includes evaluation of nine different intestinal segments (from jejunum to rectum) and of the anal canal. Read More

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http://dx.doi.org/10.1007/s00330-019-6006-5DOI Listing
February 2019
4 Reads

Pulmonary involvement in Crohn's disease.

J Bras Pneumol 2018 Nov-Dec;44(6):519-521

. Divisão de Pneumologia, Instituto do Coração - InCor - Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo, São Paulo (SP) Brasil.

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http://dx.doi.org/10.1590/S1806-37562018000000055DOI Listing
March 2019
2 Reads

Does fecal calprotectin equally and accurately measure disease activity in small bowel and large bowel Crohn's disease? - a systematic review.

Intest Res 2019 Feb 7. Epub 2019 Feb 7.

Nottingham Digestive Diseases Centre, University of Nottingham, Nottingham, UK.

Fecal calprotectin (FC) is a highly sensitive disease activity biomarker in inflammatory bowel disease. However, there are conflicting reports on whether the diagnostic accuracy in Crohn's disease is influenced by disease location. The aim of this study was to undertake a systematic review of the published literature. Read More

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http://dx.doi.org/10.5217/ir.2018.00114DOI Listing
February 2019
2 Reads

Differentiating Crohn's disease from intestinal tuberculosis.

World J Gastroenterol 2019 Jan;25(4):418-432

Department of Gastroenterology, All India Institute of Medical Sciences, New Delhi 110029, India.

Differentiating Crohn's disease (CD) and intestinal tuberculosis (ITB) has remained a dilemma for most of the clinicians in the developing world, which are endemic for ITB, and where the disease burden of inflammatory bowel disease is on the rise. Although, there are certain clinical (diarrhea/hematochezia/perianal disease common in CD; fever/night sweats common in ITB), endoscopic (longitudinal/aphthous ulcers common in CD; transverse ulcers/patulous ileocaecal valve common in ITB), histologic (caseating/confluent/large granuloma common in ITB; microgranuloma common in CD), microbiologic (positive stain/culture for acid fast-bacillus in ITB), radiologic (long segment involvement/comb sign/skip lesions common in CD; necrotic lymph node/contiguous ileocaecal involvement common in ITB), and serologic differences between CD and ITB, the only exclusive features are caseation necrosis on biopsy, positive smear for acid-fast bacillus (AFB) and/or AFB culture, and necrotic lymph node on cross-sectional imaging in ITB. However, these exclusive features are limited by poor sensitivity, and this has led to the development of multiple multi-parametric predictive models. Read More

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http://dx.doi.org/10.3748/wjg.v25.i4.418DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350172PMC
January 2019
11 Reads
2.369 Impact Factor

Absence of dentate nucleus resting-state functional connectivity changes in nonneurological patients with gadolinium-related hyperintensity on T -weighted images.

J Magn Reson Imaging 2019 Jan 25. Epub 2019 Jan 25.

Departmental Faculty of Medicine and Surgery, Università Campus Bio-Medico di Roma, Rome, Italy.

Background: The dentate nuclei of the cerebellum are the areas where gadolinium predominantly accumulates. It is not yet known whether gadolinium deposition affects brain functions.

Purpose/hypothesis: To assess whether gadolinium-dependent high signal intensity of the cerebellum on T -weighted images of nonneurological adult patients with Crohn's disease is associated with modifications of resting-state functional connectivity (RSFC) of the cerebellum and dentate nucleus. Read More

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http://dx.doi.org/10.1002/jmri.26669DOI Listing
January 2019
13 Reads

Mitochondrial neurogastrointestinal encephalopathy: a clinicopathological mimic of Crohn's disease.

BMC Gastroenterol 2019 Jan 15;19(1):11. Epub 2019 Jan 15.

Addenbrooke's Hospital, Cambridge University Hospitals NHS Foundation Trust, Cambridge, CB2 0QQ, UK.

Background: Mitochondrial neurogastrointestinal encephalopathy (MNGIE), due to mutations in TYMP, often presents with gastrointestinal symptoms. Two sisters, initially managed for Crohn's disease based upon clinical, imaging and pathological findings, were later found to have MNGIE. The cases provide novel clinicopathological insight, for two further reasons: both sisters remain ambulant and in employment in their late 20s and 30s; diagnosis in one sister was made after a suspected azathioprine-precipitated acute illness. Read More

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http://dx.doi.org/10.1186/s12876-018-0925-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6334462PMC
January 2019
10 Reads
2.365 Impact Factor

Bowel Ultrasound State of the Art: Grayscale and Doppler Ultrasound, Contrast Enhancement, and Elastography in Crohn Disease.

J Ultrasound Med 2019 Feb 3;38(2):271-288. Epub 2019 Jan 3.

Department of Medicine, Division of Gastroenterology, University of Calgary, Calgary, Alberta, Canada.

Bowel ultrasound (US) is accurate for assessing bowel inflammation and complications in Crohn disease. Additionally, contrast-enhanced US provides a quantitative, objective measurement of inflammatory activity in inflammatory bowel disease, and shear wave elastography predicts the stiffness of bowel, an increase of which suggests less response to medical therapy, often necessitating surgery. Overall, bowel US is an excellent, safe, and repeatable choice for routine surveillance and for urgent imaging. Read More

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http://dx.doi.org/10.1002/jum.14920DOI Listing
February 2019
15 Reads

Backwash ileitis in ulcerative colitis: Are there MR enterographic features that distinguish it from Crohn disease?

Eur J Radiol 2019 Jan 1;110:212-218. Epub 2018 Dec 1.

Department of Internal Medicine, School of Medicine, Ankara University, Talatpaşa Bulvarı, Sıhhiye, 06100 Ankara, Turkey. Electronic address:

Objective: To reveal the MR enterography (MRE) findings that distinguish backwash ileitis (BWI) from terminal ileitis due to Crohn's disease (CD) and to determine the usability of barium studies manifestations (ileocecal valve (ICV) gaping, terminal ileum dilatation) in MRE for the diagnosis of BWI in ulcerative colitis (UC) patients by pointing at the diagnostic performance of these imaging findings.

Subjects-methods: The study population consisted of patients who were diagnosed as ulcerative colitis (UC), and underwent 1.5 T MRI between August 2011 and November 2017 to rule out small bowel involvement. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0720048X183042
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http://dx.doi.org/10.1016/j.ejrad.2018.11.027DOI Listing
January 2019
16 Reads

Modulation of faecal metagenome in Crohn's disease: Role of microRNAs as biomarkers.

World J Gastroenterol 2018 Dec;24(46):5223-5233

Department of Digestive Diseases, Valme University Hospital, UGC Digestive Disease and CIBERehd, Servicio Andaluz de Salud, Seville E-41014, Spain.

Background: The gut microbiota plays a key role in the maintenance of intestinal homeostasis and the development and activation of the host immune system. It has been shown that commensal bacterial species can regulate the expression of host genes. 16S rRNA gene sequencing has shown that the microbiota in inflammatory bowel disease (IBD) is abnormal and characterized by reduced diversity. Read More

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http://dx.doi.org/10.3748/wjg.v24.i46.5223DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6295834PMC
December 2018
10 Reads

Differences in the imaging of Crohn's disease patients between North America and Europe: are we ready to bridge the divide?

Abdom Radiol (NY) 2018 Dec 22. Epub 2018 Dec 22.

Department of Radiology, Mayo Clinic, 200 First St SW, Rochester, MN, 55905, USA.

The emphasis of treatment in Crohn's disease has evolved from a reactive model to "treat-to-target" approaches. Cross-sectional imaging has rapidly evolved in parallel, with a growing evidence base supporting its abilities for diagnosis, monitoring and prognostication. Whilst there are differences in emphasis between Europe and North America, particularly around the type of imaging modalities and patterns of multidisciplinary care, there is increasing convergence. Read More

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http://dx.doi.org/10.1007/s00261-018-1872-xDOI Listing
December 2018
2 Reads

Case of steroid-resistant Crohn's-associated bronchiolitis in the setting of quiescent gastrointestinal disease treated with infliximab.

BMJ Case Rep 2018 Nov 28;11(1). Epub 2018 Nov 28.

Department of Respiratory Medicine, Western General Hospital, Edinburgh, UK.

A fit, 36-year-old man with a history of Crohn's disease previously treated with azathioprine, presented acutely with progressive shortness of breath on exertion and pleuritic chest pain. At the time of presentation, his Crohn's disease was quiescent, supported by a normal faecal calprotectin. The initial chest CT suggested the presence of a diffuse inflammatory disorder and he was subsequently started on high dose oral steroids. Read More

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http://dx.doi.org/10.1136/bcr-2018-226934DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6301768PMC
November 2018
1 Read

Does MR enterography offer added value after a recent CT in the evaluation of abdominal pain in Crohn's disease patients?

Clin Imaging 2019 Mar - Apr;54:78-83. Epub 2018 Dec 10.

Yale New Haven Hospital, Department of Radiology and Biomedical Imaging, 20 York Street, New Haven, CT 06520, United States of America. Electronic address:

Purpose: To determine if there is added value in performing MR enterography shortly after a contrast-enhanced CT of the abdomen and pelvis in patients with Crohn's disease presenting with acute abdominal pain.

Materials And Methods: A total of 45 consecutive patients who underwent MRE examination <7 days after a CT met our strict inclusion criteria. Independent and blinded review of both MRE and CT exams was performed by two abdominal radiologists. Read More

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http://dx.doi.org/10.1016/j.clinimag.2018.12.002DOI Listing
December 2018
2 Reads

IVIM with fractional perfusion as a novel biomarker for detecting and grading intestinal fibrosis in Crohn's disease.

Eur Radiol 2018 Dec 13. Epub 2018 Dec 13.

Department of Radiology, The First Affiliated Hospital, Sun Yat-Sen University, 58 Zhongshan II Road, Guangzhou, 510080, People's Republic of China.

Objectives: Intravoxel incoherent motion (IVIM) diffusion-weighted magnetic resonance imaging (MRI) provides information on both perfusion and diffusion and has been used to evaluate Crohn's disease (CD) activity and fibrosis in children; however, there are no reports on its use in adults. We aimed to determine its value for detecting and grading intestinal fibrosis in adults with CD compared with contrast-enhanced imaging and traditional diffusion-weighted imaging using surgical histopathology as a reference standard.

Methods: Twenty-four adults with CD underwent preoperative IVIM, traditional diffusion-weighted, and contrast-enhanced imaging. Read More

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http://dx.doi.org/10.1007/s00330-018-5848-6DOI Listing
December 2018
1 Read
4.014 Impact Factor

Fetal distress and urgent cesarean delivery due to new-onset peripartum Crohn's disease.

Taiwan J Obstet Gynecol 2018 Dec;57(6):901-902

Department of Gastroenterology, Shaare Zedek Medical Center, Hebrew University Medical School of Jerusalem, Jerusalem, Israel.

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http://dx.doi.org/10.1016/j.tjog.2018.10.025DOI Listing
December 2018
2 Reads

Comparison of MRI Activity Scoring Systems and Features for the Terminal Ileum in Patients With Crohn Disease.

AJR Am J Roentgenol 2019 Feb 12;212(2):W25-W31. Epub 2018 Dec 12.

1 Department of Radiology and Nuclear Medicine, Amsterdam UMC, University of Amsterdam, Meibergdreef 9, 1105AZ, Amsterdam, The Netherlands.

Objective: The purpose of this study was to evaluate four previously validated MRI activity scoring systems for diagnosis and grading of Crohn disease (CD) in the terminal ileum against an endoscopic and histopathologic reference standard.

Subjects And Methods: Ethics approval and written informed consent were obtained. Subjects with known or suspected CD were prospectively recruited between December 2011 and August 2014. Read More

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https://www.ajronline.org/doi/10.2214/AJR.18.19876
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http://dx.doi.org/10.2214/AJR.18.19876DOI Listing
February 2019
19 Reads

The role of intravenous Contrast Agent in the Sonographic Assessment of Crohn's Disease Activity: Is Contrast Agent Injection Necessary?

J Crohns Colitis 2018 Dec 8. Epub 2018 Dec 8.

Department of Radiology, Valencia (SPAIN).

Background: the literature shows that contrast-enhanced ultrasound (CEUS) is superior to wall thickness or color Doppler imaging (CDI) in predicting disease activity using endoscopy as the reference standard.

Objective: to determine in patients with Crohn´s disease (CD) whether the evaluation of wall thickness or CDI before CEUS examination could help decide when the injection of contrast agent is justified as a means for detecting disease activity as determined at endoscopy, without reducing the accuracy of ultrasound.

Material & Methods: 180 patients with CD underwent both colonoscopy and US, including mural thickness, CDI and CEUS evaluation, prospectively as part of clinical care. Read More

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http://dx.doi.org/10.1093/ecco-jcc/jjy204DOI Listing
December 2018
2 Reads

Integrated Care for Crohn's Disease: A Plea for the Development of Clinical Decision Support Systems.

J Crohns Colitis 2018 Nov;12(12):1499-1504

UCL: Université Catholique de Louvain - Institute of Health and Society, Belgium.

Evolution in the management of Crohn's disease [CD] has been characterized by recent paradigm changes. First, new biological therapies induce intestinal healing and full disease control in a substantial number of patients, particularly when introduced early in the disease course. However, they are expensive and associated with potentially severe side effects, raising the question of optimal treatment duration. Read More

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http://dx.doi.org/10.1093/ecco-jcc/jjy128DOI Listing
November 2018
3 Reads

Fecal calprotectin correlates with active colonic inflammatory bowel disease but not with small intestinal Crohn's disease activity.

JGH Open 2018 Oct 17;2(5):201-206. Epub 2018 Jul 17.

Division of Gastroenterology, Department of Medicine, Zane Cohen Center, Mount Sinai Hospital University of Toronto Toronto Ontario Canada.

Background: The utility of fecal calprotectin (FC) in small intestinal Crohn's disease (CD) is unclear. We examined how reliably FC reflects clinical and mucosal disease activity in small intestinal CD, colonic CD, and ulcerative colitis (UC).

Methods: A total of 72 Inflammatory Bowel Disease (IBD) patients (23 colonic CD, 14 isolated small intestinal CD, and 35 UC) were included. Read More

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http://dx.doi.org/10.1002/jgh3.12068DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6207015PMC
October 2018
11 Reads

An acute neurological complication of Crohn's disease.

Funct Neurol 2018 Jul/Sept;33(3):165-166

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February 2019
5 Reads

Ultrasound findings in extragenital endometriosis.

J Ultrason 2018 ;18(74):247-254

Medizinische Klinik 2, Caritas-Krankenhaus Bad Mergentheim, Bad Mergentheim, Germany.

We present a report on ultrasound findings in extragenital endometriosis and a literature review accompanied by illustrations. Intestinal endometriosis should be considered in female patients of reproductive age who present with constipation, gastrointestinal bleeding, nausea, vomiting, cramp-like abdominal pain, diarrhoea and pelvic pain. Although definitive preoperative diagnosis of endometriosis is difficult, clinical suspicion and appropriate imaging might prevent extensive surgical procedures with higher morbidity. Read More

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http://jultrason.pl/index.php/issues/volume-18-no-74/ultraso
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http://dx.doi.org/10.15557/JoU.2018.0036DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6442214PMC
January 2018
16 Reads

Paediatric bowel ultrasound in inflammatory bowel disease.

Eur J Radiol 2018 Nov 10;108:21-27. Epub 2018 Sep 10.

Department of Imaging, Royal Free Hospital, Royal Free London NHS Foundation Trust, London, UK.

Ultrasound has long been favoured as first line when imaging children, primarily due to it being a non-invasive, relatively low cost, easily accessible modality. The many advantages of ultrasound evaluation in paediatric inflammatory bowel disease (IBD) vastly outweighs its limitations in both initial assessment and long term follow up. High frequency ultrasound provides excellent spatial resolution, and Doppler evaluation and compression sonography aids in providing real-time dynamic assessment in IBD where other modalities cannot. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0720048X183030
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http://dx.doi.org/10.1016/j.ejrad.2018.09.004DOI Listing
November 2018
17 Reads

[Definition, epidemiology and risk factors of obstetric anal sphincter injuries: CNGOF Perineal Prevention and Protection in Obstetrics Guidelines].

Gynecol Obstet Fertil Senol 2018 12 29;46(12):913-921. Epub 2018 Oct 29.

Service de gynécologie-obstétrique, hôpitaux de Nantes, CHU Hôtel-Dieu, 38, boulevard Jean-Monnet, 44000 Nantes, France; Université de Nantes, 1, rue Gaston-Veil, 44000 Nantes, France.

Objectives: The aim of this review was to agree on a definition of the obstetric anal sphincter injuries (OASIS), to determine the prevalence and risk factors.

Methods: A comprehensive review of the literature on the obstetric anal sphincter injuries (OASIS), establishment of levels of evidence (NP), and grades of recommendation according to the methodology of the recommendations for clinical practice.

Results: To classify obstetric anal sphincter injuries (OASIS), we have used the WHO-RCOG classification, which lists 4 degrees of severity. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S24687189183028
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http://dx.doi.org/10.1016/j.gofs.2018.10.028DOI Listing
December 2018
9 Reads

Curved planar reformatting and convolutional neural network-based segmentation of the small bowel for visualization and quantitative assessment of pediatric Crohn's disease from MRI.

J Magn Reson Imaging 2018 Oct 24. Epub 2018 Oct 24.

Computational Radiology Laboratory, Department of Radiology, Children's Hospital Boston, Harvard Medical School, Boston, Massachusetts, USA.

Background: Contrast-enhanced MRI of the small bowel is an effective imaging sequence for the detection and characterization of disease burden in pediatric Crohn's disease (CD). However, visualization and quantification of disease burden requires scrolling back and forth through 3D images to follow the anatomy of the bowel, and it can be difficult to fully appreciate the extent of disease.

Purpose: To develop and evaluate a method that offers better visualization and quantitative assessment of CD from MRI. Read More

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http://dx.doi.org/10.1002/jmri.26330DOI Listing
October 2018
5 Reads

HPV papilloma in the lung in a Crohn's disease patient treated with Infliximab.

Acta Gastroenterol Belg 2018 Jul-Sep;81(3):439-440

Department of Internal Medicine, Sint-Trudoziekenhuis, Sint-Truiden.

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February 2019

Coronary artery ectasia in Crohn's disease.

BMJ Case Rep 2018 Oct 21;2018. Epub 2018 Oct 21.

Third Department of Cardiology, Hygeia Hospital, Athens, Attica, Greece.

Coronary artery ectasia (CAE) can be ascribed, in the majority of cases, to coronary atherosclerosis. Nevertheless, the presence of isolated ectatic lesions without obstructive coronary artery disease and the association of CAE with several autoimmune diseases characterised by systemic vascular involvement suggest that the pathogenesis of CAE may extend beyond coronary atherosclerosis. We herein report the case of a 56-year-old male patient with Crohn's disease and isolated CAE, who has been found positive for IgM and IgA antiendothelial cell antibodies, and discuss a potential pathogenic mechanism. Read More

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http://dx.doi.org/10.1136/bcr-2018-226813DOI Listing
October 2018
1 Read

The Clinical and Cost-Effectiveness of 4 Enzyme-Linked Immunosorbent Assay Kits for Monitoring Infliximab in Crohn Disease Patients: Protocol for a Validation Study.

JMIR Res Protoc 2018 Oct 19;7(10):e11218. Epub 2018 Oct 19.

Department of Gastroenterology, Guy's & St Thomas' National Health Service Trust, London, United Kingdom.

Background: Currently, treatment decisions for people with Crohn disease are based on clinical judgment and trial and error. Consequently, people may continue to receive high drug dosages and experience unnecessary toxicity when it is possible to reduce or discontinue without a detrimental effect on clinical outcomes. Therapeutic drug monitoring (TDM) involves regularly testing blood samples for drug and antibody levels that could help clinicians identify the optimal treatment strategy and pre-empt treatment failure. Read More

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http://www.researchprotocols.org/2018/10/e11218/
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http://dx.doi.org/10.2196/11218DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6231806PMC
October 2018
25 Reads

Reduced Imaging Radiation Exposure and Costs Associated with Anti-Tumor Necrosis Factor Therapy in Crohn's Disease.

Dig Dis Sci 2019 01 11;64(1):60-67. Epub 2018 Oct 11.

University of Maryland, 685 W. Baltimore St., Suite 8-00, Baltimore, MD, 21201, USA.

Background: Radiation exposure from diagnostic imaging may increase cancer risk of Crohn's disease (CD) patients, who are already at increased risk of certain cancers.

Aim: To compare imaging radiation exposure and associated costs in CD patients during the year pre- and post-initiation of anti-tumor necrosis factor (anti-TNF) agents or corticosteroids.

Methods: Adults were identified from a large US claims database between 1/1/2005 and 12/31/2009 with ≥ 1 abdominal imaging scan and 12 months of enrollment before and after initiating therapy with anti-TNF or corticosteroids. Read More

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http://dx.doi.org/10.1007/s10620-018-5322-yDOI Listing
January 2019
5 Reads

Ram's Horn Sign: Gastric antrum in Crohn's disease.

J Med Imaging Radiat Oncol 2018 Oct;62 Suppl 1:101

Department of Radiology, Concord Repatriation General Hospital, Concord, New South Wales, Australia.

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http://dx.doi.org/10.1111/1754-9485.45_12784DOI Listing
October 2018
3 Reads

Cerebral granulomatosis as a manifestation of Crohn's disease.

BMC Neurol 2018 Oct 3;18(1):161. Epub 2018 Oct 3.

Department of Neurology and Neuroscience, Medical Center, University of Freiburg, Breisacher Straße 64, D-79106, Freiburg, Germany.

Background: Crohn's disease (CD) is associated with a variety of extra-intestinal manifestations. Most commonly these involve the eye, skin, joints, coagulation system and liver. Cerebral manifestations of CD have been reported to a far lesser extent. Read More

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http://dx.doi.org/10.1186/s12883-018-1163-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6169107PMC
October 2018
18 Reads

Posterior Reversible Encephalopathy Syndrome following Ustekinumab Induction for Crohn's Disease.

Case Rep Gastroenterol 2018 May-Aug;12(2):521-527. Epub 2018 Aug 29.

Division of Gastroenterology and Hepatology, Rutgers-Robert Wood Johnson Medical School, New Brunswick, New Jersey, USA.

Biological agents are frequently used in the management of inflammatory bowel disease, and it is important to understand the potential adverse effects of these therapies. Ustekinumab is a human monoclonal antibody that interferes with interleukin-12 and -23 cytokine signaling and is approved for the treatment of moderate to severe Crohn's disease. We report 2 cases of neurological adverse events, one of which is consistent with posterior reversible encephalopathy syndrome (PRES), in the setting of ustekinumab therapy for Crohn's disease. Read More

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http://dx.doi.org/10.1159/000492462DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6167711PMC
August 2018
20 Reads

Creeping Fat Assessed by Small Bowel MRI Is Linked to Bowel Damage and Abdominal Surgery in Crohn's Disease.

Dig Dis Sci 2019 01 1;64(1):204-212. Epub 2018 Oct 1.

Department of Gastroenterology and Hepatology, Berufsgenossenschaftliches Universitätsklinikum Bergmannsheil gGmbH, Ruhr-University Bochum, Bürkle-de-la-Camp-Platz 1, 44789, Bochum, Germany.

Background: Crohn's disease (CD) leads to bowel damage and surgery in a significant proportion of patients.

Aims: The aim of the study was to evaluate the predictive value of creeping fat assessed by small bowel MRI in CD patients.

Methods: CD patients undergoing small bowel MRI were included in a retrospective observational cohort study. Read More

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http://dx.doi.org/10.1007/s10620-018-5303-1DOI Listing
January 2019
5 Reads

Neurotransmitter alterations in the anterior cingulate cortex in Crohn's disease patients with abdominal pain: A preliminary MR spectroscopy study.

Neuroimage Clin 2018 18;20:793-799. Epub 2018 Sep 18.

Department of Radiology, The First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, China. Electronic address:

Purpose: Crohn's disease (CD) has been known to cause both abdominal pain alongside functional and structural alterations in the central nervous system (CNS) in affected patients. This study seeks to determine the alternations of metabolites in the bilateral anterior cingulate cortex (ACC) of CD patients with abdominal pain by using proton magnetic resonance spectroscopy (H-MRS) to further explore the neural mechanism.

Methods: Sixteen CD patients with abdominal pain and 13 CD patients without abdominal pain, were recruited alongside 20 healthy controls (HCs) for this study. Read More

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http://dx.doi.org/10.1016/j.nicl.2018.09.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6169252PMC
January 2019
4 Reads

Lower Subcutaneous or Visceral Adiposity Assessed by Abdominal Computed Tomography Could Predict Adverse Outcome in Patients With Crohn's Disease.

J Crohns Colitis 2018 Nov;12(12):1429-1437

Rouen University Hospital, Department of Radiology, Rouen cedex, France.

Background And Aims: Changes in body composition have been described in patients with Crohn's disease, but their predictive performances on disease evolution remain undefined. The aims of our study were to assess, in patients with Crohn's disease requiring abdominal computed tomography, body composition by computed tomography, and to study the outcome according to various body composition parameters at the time of the computed tomography.

Methods: Patients with Crohn's disease who underwent abdominal computed tomography for suspected complications were retrospectively included. Read More

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http://dx.doi.org/10.1093/ecco-jcc/jjy124DOI Listing
November 2018
2 Reads

Management of inflammatory bowel disease.

Med J Aust 2018 Sep;209(7):318-323

St Vincent's Hospital Melbourne, Melbourne, VIC.

Australia has one of the highest incidence rates of inflammatory bowel disease (IBD) in the world. Early diagnosis and treatment for IBD is critical. For Crohn disease, in particular, this may change the natural history of disease and reduce disability. Read More

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September 2018
7 Reads

When IBD is not IBD.

Scand J Gastroenterol 2018 Sep 26;53(9):1085-1088. Epub 2018 Sep 26.

a Department of Gastroenterology and Hepatology , University Hospitals Leuven, KU Leuven , Leuven , Belgium.

Entamoeba histolytica colitis can mimic Crohn's disease. However, a fulminant infection can be life-threatening, especially after exposure to systemic steroids. We present a case of the patient who was initially diagnosed with ileocolonic Crohn's disease, but developed a hepatic E histolytica abscess while undergoing anti-TNF therapy. Read More

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http://dx.doi.org/10.1080/00365521.2018.1500637DOI Listing
September 2018
18 Reads
2.329 Impact Factor