4,943 results match your criteria Imaging in Crohn Disease


"Inflammatory Bowel Disease-Not Just the Bowel's Bane": Peripheral Arterial and Venous Thrombosis in a Patient With Crohn Disease.

Vasc Endovascular Surg 2020 Jul 8:1538574420939360. Epub 2020 Jul 8.

Department of Vascular Surgery, Westchester Medical Center, New York Medical College, Valhalla, NY, USA.

Introduction: Inflammatory bowel disease (IBD) is a chronic multisystem inflammatory condition with associated endothelial dysfunction and dysregulated coagulation. Although deep venous thrombosis (DVT) in IBD has been well described, arterial thrombosis and thromboembolism are less commonly appreciated.

Methods: A 63-year-old male with a known history of Crohn disease presented with acute-onset right arm pain. Read More

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http://dx.doi.org/10.1177/1538574420939360DOI Listing

Capsule endoscopy in inflammatory bowel disease: when and how.

Intest Res 2020 Jul 7. Epub 2020 Jul 7.

Center for Advanced IBD Research and Treatment, Kitasato University Kitasato Institute Hospital, Tokyo, Japan.

Capsule endoscopy (CE) is emerging as an important investigation in inflammatory bowel disease (IBD); common types include the standard small bowel CE and colon CE. More recently, the pan-enteric CE was developed to assess the large and small bowel in patients with Crohn's disease (CD). Emerging indications include noninvasive assessment for mucosal healing (both in the small bowel and the colon) and detection of postoperative recurrence in patients with CD. Read More

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http://dx.doi.org/10.5217/ir.2019.09165DOI Listing

Magnetic resonance imaging assessment of body composition parameters in Crohn's disease.

Dig Liver Dis 2020 Jul 1. Epub 2020 Jul 1.

Department of Radiology, Rouen University Hospital-Charles Nicolle, 1 rue de Germont, F-76031 Rouen cedex, France; UNIROUEN, Quantif-LITIS EA 4108, Normandie Université, Rouen University Hospital, France. Electronic address:

Background: Body composition, currently evaluated by computed tomography scan, is related to poor evolution and severity of Crohn's disease (CD). Few MRI studies have been performed, yet it is the most commonly used imaging modality for the surveillance of the disease.

Aim: Evaluate the feasibility of MRI body composition measurement and compare the variation according to the activity of the disease. Read More

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http://dx.doi.org/10.1016/j.dld.2020.06.024DOI Listing

Management of Primary Nonresponders and Partial Responders to Tumor Necrosis Factor-α Inhibitor Induction Therapy among Patients with Crohn's Disease.

Inflamm Intest Dis 2020 Jun 6;5(2):78-83. Epub 2020 Mar 6.

Center for Advanced IBD Research and Treatment, Kitasato University Kitasato Institute Hospital, Tokyo, Japan.

Induction therapy with tumor necrosis factor-α (TNF-α) inhibitors is highly effective for the treatment of Crohn's disease. However, there are primary nonresponders (PNR) of TNF-α inhibitors without clinical response during the induction period. In addition, there are partial responders (PR), who show some efficacy, but clinical remission is not achieved by induction therapy. Read More

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http://dx.doi.org/10.1159/000506337DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7315201PMC

Cerebral venous thrombosis: report of 2 cases of hemorrhagic venous infarction.

Radiol Case Rep 2020 Aug 18;15(8):1295-1300. Epub 2020 Jun 18.

Department of Radiology, University Hospital Gabriel Montpied, Clermont Ferrand, France.

Cerebral venous thrombosis (CVT), a rare but potentially severe cerebrovascular disease, is defined as the thrombosis of a cortical or deep cerebral vein, or a cerebral venous sinus. This article reports 2 cases of CVT. In the first case, the patient is a 40-year-old woman with a history of 2 miscarriages, using oral contraception and presenting intense headache, cervical irradiation, and drowsiness. Read More

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http://dx.doi.org/10.1016/j.radcr.2020.05.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7306535PMC

Fibrogenesis in chronic murine colitis is independent of innate lymphoid cells.

Immun Inflamm Dis 2020 Jun 21. Epub 2020 Jun 21.

Department of Microbiology, Immunology and Transplantation, Allergy and Clinical Immunology Research Group, KU Leuven, Leuven, Belgium.

Introduction: Insight in the pathogenesis of intestinal fibrosis is an unmet medical need in inflammatory bowel diseases. Studies in murine models and human organ fibrosis point to a potential role of innate lymphoid cells (ILC) in chronic intestinal inflammation and fibrosis.

Materials And Methods: Dextran sodium sulfate (DSS) in drinking water was used to induce chronic colitis and remodeling in C57Bl/6 wild type (WT), RAG-deficient, RAG common γ chain deficient and anti-CD90. Read More

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http://dx.doi.org/10.1002/iid3.321DOI Listing

Ulcer severity grading in video-capsule images of Crohn's disease patients: an ordinal neural network solution.

Gastrointest Endosc 2020 Jun 12. Epub 2020 Jun 12.

Department of Gastroenterology, Sheba Medical Center, Tel Hashomer, Israel, and Sackler Medical School, Tel Aviv University, Tel Aviv, Israel.

Background And Aims: Capsule endoscopy (CE) is an important modality for Crohn's disease (CD) diagnosis and follow-up. Endoscopic severity of ulcers is of much significance for prediction of CD course. Deep learning has been proven accurate in detecting ulcers on CE. Read More

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http://dx.doi.org/10.1016/j.gie.2020.05.066DOI Listing

Radiological outcomes in perianal fistulizing Crohn's disease: A systematic review and meta-analysis.

JGH Open 2020 Jun 30;4(3):340-344. Epub 2019 Dec 30.

Department of Gastroenterology St Vincent's Hospital Melbourne Victoria Australia.

Perianal fistulas are a common and debilitating manifestation of Crohn's disease. Since the advent of biological agents, patient outcomes appear to have improved. While rates of clinical response and remission are well characterized in literature, magnetic resonance imaging (MRI) outcomes remain less so. Read More

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http://dx.doi.org/10.1002/jgh3.12295DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7273731PMC

Panenteric capsule endoscopy versus ileocolonoscopy plus magnetic resonance enterography in Crohn's disease: a multicentre, prospective study.

BMJ Open Gastroenterol 2020 Jun;7(1)

Department of Radiology, Mayo Clinic, Rochester, Minnesota, USA.

Introduction: Crohn's disease diagnosis and monitoring remains a great clinical challenge and often requires multiple testing modalities. Assessing Crohn's disease activity in the entire gastrointestinal (GI) tract using a panenteric capsule endoscopy (CE) system could be used as an alternative to colonoscopy and cross-sectional imaging. This study assessed the accuracy and safety of panenteric CE in Crohn's disease as compared with ileocolonoscopy (IC) and/or magnetic resonance enterography (MRE). Read More

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http://dx.doi.org/10.1136/bmjgast-2019-000365DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7282309PMC

Emerging Roles of PET/MR in the Pediatric Hospital.

PET Clin 2020 Jul;15(3):253-269

Radiology Department, Children's Hospital of Philadelphia, 3401 Civic Center Boulevard, Philadelphia, PA 19104, USA; Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA; Section of Oncologic Imaging, Radiology Department, Children's Hospital of Philadelphia, 3401 Civic Center Boulevard, Philadelphia, PA 19104, USA. Electronic address:

Add "improving" before "detection"? PET/MR is beneficial particularly in pediatric patients who undergo recurrent imaging, such as those with cancer or chronic inflammatory disease. PET/MR has advantages compared with PET/computed tomography, including decreased radiation exposure and superior characterization of soft tissue. Ongoing challenges include reducing examination duration and costs and detection of pulmonary lesions. Read More

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http://dx.doi.org/10.1016/j.cpet.2020.03.005DOI Listing

Prevalence and clinical significance of incidental extra-intestinal findings in MR enterography: experience of a single University Centre.

Radiol Med 2020 Jun 3. Epub 2020 Jun 3.

Section of Diagnostic Imaging, Interdisciplinary Department of Medicine, University of Bari "Aldo Moro", Piazza Giulio Cesare, 11, 70123, Bari, Italy.

Purpose: To determine the incidence and clinical relevance of extra-intestinal incidental findings (IF) in a cohort of patients with proven or suspected Crohn disease (CD) examined with magnetic resonance enterography (MR-E) in a single University Centre.

Methods: Between January 2018 and June 2019, 182 patients with proven or suspected CD with a planned first MR-E examination, were retrospectively included in this study. Incidental findings were considered as any abnormality identified in the absence of previous clinically suspected or known disease. Read More

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http://dx.doi.org/10.1007/s11547-020-01235-6DOI Listing

FDG-PET-CT Enterography Helps Determine Clinical Significance of Suspected Ileocecal Thickening: A Prospective Study.

Dig Dis Sci 2020 Jun 1. Epub 2020 Jun 1.

Department of Gastroenterology, Postgraduate Institute of Medical Education and Research, Chandigarh, 160012, India.

Background: Ileocecal thickening (ICT) on imaging could result from diverse etiologies but may also be clinically insignificant.

Aim: Evaluation of role of combined 2-deoxy-2-fluorine-18-fluoro-D-glucose(F-FDG)-positron emission tomography and computed tomographic enterography (PET-CTE) for determination of clinical significance of suspected ICT.

Methods: This prospective study enrolled consecutive patients with suspected ICT on ultrasound. Read More

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http://dx.doi.org/10.1007/s10620-020-06361-9DOI Listing
June 2020
2.550 Impact Factor

Enterocutaneous Fistula: A Simplified Clinical Approach.

Cureus 2020 Apr 22;12(4):e7789. Epub 2020 Apr 22.

Surgery, Stanford University, Palo Alto, USA.

A "fistula" is an abnormal connection between two epithelial surfaces. Fistulae are named based on the two surfaces or lumens they connect to. Fistulae form due to loss of wall integrity from an underlying insult, leading to the penetrance of an adjacent organ or epithelized surface. Read More

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http://dx.doi.org/10.7759/cureus.7789DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7243661PMC

Crohn's disease: prevalence, MR features, and clinical significance of enteric and colonic sinus tracts.

Eur Radiol 2020 May 26. Epub 2020 May 26.

Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Waehringer Guertel 18-20, 1090, Vienna, Austria.

Objectives: Enteric and colonic sinus tracts are inflammatory complications that precede intestinal fistulas in patients with Crohn's disease (CD). The aim of this study was to retrospectively determine the prevalence, morphologic features, and outcome of sinus tracts using MR imaging.

Methods: A consecutive cohort of 642 patients with known CD, referred for MR enterography or MR enteroclysis (study period 01/2014-09/2019), was evaluated retrospectively for the presence of sinus tracts, their locations, presence and length of coexisting strictures, bowel wall thickness, CDMI score, upstream dilation, and bowel distension. Read More

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http://dx.doi.org/10.1007/s00330-020-06935-1DOI Listing

Evolution of Inflammatory Bowel Disease Research From a Bird's-Eye Perspective: A Text-Mining Analysis of Publication Trends and Topics.

Inflamm Bowel Dis 2020 May 22. Epub 2020 May 22.

Department of Gastroenterology, Sheba Medical Center, Tel Hashomer, Israel.

Background And Aim: Inflammatory bowel disease (IBD) research is extensive and increasing, with topics varying and shifting foci over time. A comprehensive analysis of the trends in IBD publications may help us grasp knowledge gaps and map future areas of interest. The aim of our study was to create a map of IBD research for the last 25 years using computational text-mining techniques. Read More

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http://dx.doi.org/10.1093/ibd/izaa091DOI Listing

The Role of Citrullination in Inflammatory Bowel Disease: A Neglected Player in Triggering Inflammation and Fibrosis?

Inflamm Bowel Dis 2020 May 19. Epub 2020 May 19.

KU Leuven Department of Chronic Diseases, Metabolism and Ageing, Translational Research Center for Gastrointestinal Disorders, Leuven, Belgium.

Citrullination is a posttranslational modification of proteins mediated by a specific family of enzymes called peptidylarginine deiminases (PAD). Dysregulation of these enzymes is involved in the etiology of various diseases, from cancer to autoimmune disorders. In inflammatory bowel disease (IBD), data for a role of citrullination in the disease process are starting to accumulate at different experimental levels including gene expression analyses, RNA, and protein quantifications. Read More

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http://dx.doi.org/10.1093/ibd/izaa095DOI Listing

Cross-sectional imaging for assessing intestinal fibrosis in Crohn's disease.

J Dig Dis 2020 May 17. Epub 2020 May 17.

Department of Radiology, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China.

More than 30% of Crohn's disease (CD) patients develop fibrotic strictures in the bowel as the disease progresses. Excessive deposition of extracellular matrix components in the submucosa, and smooth muscle hypertrophy/ hyperplasia are the main features of fibrosis in CD. Cross-sectional imaging technology provides a wealth of information on the anatomy, histological composition, and physiological function, allowing for a non-invasive and complete evaluation of associated abnormalities. Read More

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http://dx.doi.org/10.1111/1751-2980.12881DOI Listing

Modified Van Assche magnetic resonance imaging-based score for assessing the clinical status of anal fistulas.

Medicine (Baltimore) 2020 May;99(19):e20075

Department of Integrated Traditional Chinese and Western Medicine, West China Hospital, Sichuan University.

The modified Van Assche magnetic resonance imaging (MRI)-based score is a feasible system to assess the clinical status of anal fistulas in Crohn disease. In this study, we evaluated this score's association with clinical status in patients with anal fistulas (AFs).We included all patients with AF who underwent contrast-enhanced pelvic MRI and surgery between January 2011 and December 2016. Read More

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http://dx.doi.org/10.1097/MD.0000000000020075DOI Listing

ACR Appropriateness Criteria® Crohn Disease.

J Am Coll Radiol 2020 May;17(5S):S81-S99

Specialty Chair, Virginia Commonwealth University Medical Center, Richmond, Virginia.

Three common clinical scenarios involving use of imaging in Crohn disease are covered. These include the initial evaluation of Crohn disease when the diagnosis has not been previously established, the evaluation for anticipated exacerbation of known disease, and the evaluation of disease activity during therapy monitoring. The appropriateness of a given imaging modality for each scenario is rated as one of three categories (usually appropriate, may be appropriate, usually not appropriate) to help guide evaluation. Read More

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http://dx.doi.org/10.1016/j.jacr.2020.01.030DOI Listing

MR enterography - Impact on image quality between single- versus split-dose Buscopan.

J Med Imaging Radiat Oncol 2020 Jun 28;64(3):331-337. Epub 2020 Apr 28.

Department of Medical Imaging, Royal Brisbane and Women's Hospital, Brisbane, Queensland, Australia.

Introduction: MR enterography (MRE) is the most common imaging modality used to assess small bowel pathology, particularly patients with suspected Crohn's disease. Spasmolytic agents, most commonly Buscopan, are routinely used to reduce or cease movement/bowel activity in order to reduce blurring of the images which would otherwise reduce its diagnostic quality. The purpose of this study was to determine if administering an evenly split dose of Buscopan would improve the quality of images obtained relative to the standard single dose performed at our institution. Read More

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http://dx.doi.org/10.1111/1754-9485.13033DOI Listing

Differentiation of fibrotic and inflammatory component of Crohn's disease-associated strictures.

Intest Res 2020 Apr 20;18(2):144-150. Epub 2020 Apr 20.

Department of Radiology, Hospital Clinic Barcelona, Barcelona, Spain.

Patients with Crohn's disease (CD) commonly develop bowel strictures, which may contain various degrees of inflammation and fibrosis. While predominantly inflammatory strictures may benefit from a medical anti-inflammatory treatment approach, fibrotic strictures would require endoscopic balloon dilation or surgery. Cross-sectional imaging surpasses endoscopy for characterization of stenotic segments and potentially may contribute to the optimal clinical management of these patients. Read More

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http://dx.doi.org/10.5217/ir.2020.00015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7206345PMC

Evaluating inflammatory activity in Crohn's disease by cross-sectional imaging techniques.

Radiol Bras 2020 Jan-Feb;53(1):38-46

Escola Paulista de Medicina da Universidade Federal de São Paulo (EPM-Unifesp), São Paulo, SP, Brazil.

The evaluation of inflammatory bowel activity in patients with Crohn's disease has traditionally been a challenge, mainly because of the difficulty in gaining endoscopic access to the small bowel. Historically, barium-based contrast studies were the only option for the evaluation of inflammatory activity in Crohn's disease. They were gradually replaced by cross-sectional imaging techniques, computed tomography enterography (CTE) and magnetic resonance enterography (MRE) now being the modalities of choice for such evaluations. Read More

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http://dx.doi.org/10.1590/0100-3984.2018.0096DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7159043PMC

Intestinal tuberculosis or Crohn's disease: a review of the diagnostic models designed to differentiate between these two gastrointestinal diseases.

Intest Res 2020 Apr 22. Epub 2020 Apr 22.

Division of Gastroenterology, Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.

Differentiating Crohn's disease (CD) from intestinal tuberculosis (ITB) is a diagnostic dilemma, particularly in regions where ITB is prevalent and CD incidence is increasing, because both diseases can present quite similarly, and diagnostic tests to identify Mycobacterium tuberculosis in tissue samples have rather poor sensitivity. Studies that were conducted to determine the factors that differentiate CD from ITB identified some significant characteristics, but none of those characteristics are exclusive to either ITB or CD. Many diagnostic models or scoring systems that use one to several diagnostic parameters have been proposed to help distinguish these two intestinal diseases. Read More

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http://dx.doi.org/10.5217/ir.2019.09142DOI Listing

British Society of Gastroenterology guidance for management of inflammatory bowel disease during the COVID-19 pandemic.

Gut 2020 06 17;69(6):984-990. Epub 2020 Apr 17.

University of Edinburgh, Edinburgh, UK

The COVID-19 pandemic is putting unprecedented pressures on healthcare systems globally. Early insights have been made possible by rapid sharing of data from China and Italy. In the UK, we have rapidly mobilised inflammatory bowel disease (IBD) centres in order that preparations can be made to protect our patients and the clinical services they rely on. Read More

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http://dx.doi.org/10.1136/gutjnl-2020-321244DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7211081PMC
June 2020
14.660 Impact Factor

Quantitative Inflammation Assessment for Crohn Disease Using Ultrasensitive Ultrasound Microvessel Imaging: A Pilot Study.

J Ultrasound Med 2020 Apr 16. Epub 2020 Apr 16.

Departments of Radiology, Mayo Clinic, Rochester, Minnesota, USA.

Objectives: Crohn disease (CD) is a chronic inflammation in the digestive tract that affects millions of Americans. Bowel vascularity has important diagnostic information because inflammation is associated with blood flow changes. We recently developed an ultrasensitive ultrasound microvessel imaging (UMI) technique with high vessel sensitivity. Read More

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http://dx.doi.org/10.1002/jum.15290DOI Listing

Comparison of small intestinal contrast ultrasound with magnetic resonance enterography in pediatric Crohn's disease.

JGH Open 2020 Apr 19;4(2):126-131. Epub 2019 Jul 19.

Centre for Medical Imaging University College London London UK.

Aim: To compare the diagnostic yield of small intestinal contrast ultrasonography (SICUS) with magnetic resonance enterography (MRE) in routine clinical practice in a cohort of pediatric patients investigated for Crohn's disease (CD) attending a UK tertiary center.

Methods And Results: Patients with suspected or established CD who underwent SICUS were identified retrospectively. SICUS was compared to conventional transabdominal ultrasound (TUS), ileocolonoscopy (IC), and MRE. Read More

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http://dx.doi.org/10.1002/jgh3.12228DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7144762PMC

Beyond Crohn Disease: Current Role of Radiologists in Diagnostic Imaging Assessment of Inflammatory Bowel Disease Transitioning from Pediatric to Adult Patients.

Radiol Clin North Am 2020 May;58(3):517-527

Department of Radiology, Boston Children's Hospital, Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115, USA.

Inflammatory bowel disease (IBD) has a rising prevalence in children and an increasing number of adults living with IBD were diagnosed in childhood. This chronic disorder requires frequent cross-sectional imaging for evaluating disease progression. Radiologists must be vigilant to detect and understand imaging manifestations of acute and chronic, alimentary, and extraintestinal findings of IBD. Read More

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http://dx.doi.org/10.1016/j.rcl.2020.01.007DOI Listing

Thromboembolic events in inflammatory bowel disease.

J Med Vasc 2020 Apr 29;45(2):67-71. Epub 2020 Jan 29.

Gastroenterology department, Sahloul University Hospital, Sousse, Tunisia.

Goal Of The Study: Inflammatory bowel disease (IBD) is associated with an increased risk of thromboembolic events (TEE) during outbreaks, increasing morbidity and mortality. The aim of our study was to specify the prevalence of TEE in IBD patients and to determine their epidemiological, clinical and evolutionary characteristics.

Materiel And Methods: This is a retrospective study collecting all patients with IBD, who had a thromboembolic complication confirmed by imagery, between January 2012 and December 2018. Read More

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http://dx.doi.org/10.1016/j.jdmv.2020.01.148DOI Listing

Crohn's Disease Activity Quantified by Iodine Density Obtained From Dual-Energy Computed Tomography Enterography.

J Comput Assist Tomogr 2020 Mar/Apr;44(2):242-247

From the NYU Langone Health Departments of Radiology and Gastroenterology New York, NY.

Objective: The objective of this study was to assess if bowel wall iodine density obtained from dual-source, dual-energy computed tomography enterography (DECTE) could be a biomarker of Crohn's disease activity.

Methods: Twenty-two patients with Crohn's disease imaged with DECTE from February 2016 to May 2018 were retrospectively identified by departmental report search. Iodine maps were created with commercial software (Syngovia). Read More

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http://dx.doi.org/10.1097/RCT.0000000000000986DOI Listing

Idiopathic acute pancreatitis in patients with inflammatory bowel disease: A multicenter cohort study.

Pancreatology 2020 Apr 19;20(3):331-337. Epub 2020 Feb 19.

Gastroenterology and Hepatology Department, Hospital Universitario Ramón y Cajal, Universidad de Alcalá, Instituto Ramón y Cajal de Investigación Biosanitaria (IRYCIS), Madrid, Spain.

Background: Idiopathic acute pancreatitis (IAP) in patients with inflammatory bowel disease (IBD) is not well characterized. Our purpose was to better understand this condition and its natural history.

Methods: Retrospective cohort study conducted at nine Spanish IBD referral centers. Read More

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http://dx.doi.org/10.1016/j.pan.2020.02.007DOI Listing

Increased Postoperative Use of Computed Tomography Following Emergency Surgery for Ileocaecal Crohn Disease.

Surg Laparosc Endosc Percutan Tech 2020 Jun;30(3):214-217

Portsmouth Hospitals NHS Trust.

Introduction: Multiple imaging modalities are often required for the relapsing nature of Crohn disease (CD). Computed tomography (CT) offers a rapid acquisition of images and shows high specificity and sensitivity. However, CT imaging exposes to a higher dose of ionizing radiation than other abdominal imaging modalities. Read More

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http://dx.doi.org/10.1097/SLE.0000000000000778DOI Listing

Allogeneic hematopoietic stem cell transplantation for Crohn disease complicated with myelodysplastic syndrome: A case report.

Medicine (Baltimore) 2020 Mar;99(10):e19450

Department of Hepatology, The First Hospital of Jilin University, Chang chun, China.

Rationale: Myelodysplastic syndrome (MDS) can be complicated with Crohn disease (CD). Irritable bowel disease (IBD) associated with MDS has already been reported in the past; however, hematopoietic stem cell transplantation (HSCT) is rarely performed. Herein, we report a case of CD with MDS for HSCT. Read More

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http://dx.doi.org/10.1097/MD.0000000000019450DOI Listing

Successful Therapy of Crohn's Disease-Associated Pulmonary Necrobiotic Nodules on Ustekinumab Therapy.

Am J Gastroenterol 2020 04;115(4):632-634

Department of Medicine 1, University Hospital, Friedrich-Alexander-Universität Erlangen-Nürnberg, Germany.

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http://dx.doi.org/10.14309/ajg.0000000000000571DOI Listing

FDG-PET/CT in Inflammatory Bowel Disease: Is There a Future?

PET Clin 2020 Apr;15(2):153-162

Department of Radiology and Nuclear Medicine, Hospital of Southwest Jutland, Finsensgade 35, Esbjerg Dk-6700, Denmark; Department of Regional Health Research, University of Southern Denmark, Odense, Denmark. Electronic address:

FDG-PET/CT has potential in inflammatory bowel disease. The literature generally presents good sensitivity and specificity in various settings. At present, the most promising roles are assessment of early treatment response and stricture characterization, whereas general use in the initial diagnostic workup should be reserved for equivocal cases for the time being. Read More

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http://dx.doi.org/10.1016/j.cpet.2019.11.006DOI Listing

Brain Resting-State Network Alterations Associated With Crohn's Disease.

Front Neurol 2020 18;11:48. Epub 2020 Feb 18.

IBD Clinical and Research Centre, University of Manitoba, Winnipeg, MB, Canada.

Inflammatory bowel disease (IBD) is a chronic disease that is associated with aspects of brain anatomy and activity. In this preliminary MRI study, we investigated differences in brain structure and in functional connectivity (FC) of brain regions in 35 participants with Crohn's disease (CD) and 21 healthy controls (HC). Voxel-based morphometry (VBM) analysis was performed to contrast CD and HC structural images. Read More

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http://dx.doi.org/10.3389/fneur.2020.00048DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7040490PMC
February 2020

Comparison of Three Magnetization Transfer Ratio Parameters for Assessment of Intestinal Fibrosis in Patients with Crohn's Disease.

Korean J Radiol 2020 Mar;21(3):290-297

Department of Radiology, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China.

Objective: To establish a novel standardized magnetization transfer ratio (MTR) parameter which considers the element of the normal bowel wall and to compare the efficacy of the MTR, normalized MTR, and standardized MTR in evaluating intestinal fibrosis in Crohn's disease (CD).

Materials And Methods: Abdominal magnetization transfer imaging from 20 consecutive CD patients were analyzed before performing elective operations. MTR parameters were calculated by delineating regions of interest in specified segments on MTR maps. Read More

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http://dx.doi.org/10.3348/kjr.2019.0217DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7039729PMC

Can diffusion weighted imaging be used as an alternative to contrast-enhanced imaging on magnetic resonance enterography for the assessment of active inflammation in Crohn disease?

Medicine (Baltimore) 2020 Feb;99(8):e19202

Karadeniz Technical University, Faculty of Medicine, Department of Gastroenterology, Trabzon, Turkey.

The present study aimed to investigate the potential use of T2-weighted sequences with diffusion weighted imaging (DWI) in magnetic resonance (MR) enterography instead of conventional contrast-enhanced MR imaging (MRI) sequences for the evaluation of active inflammation in Crohn disease.Two-hundred thirteen intestinal segments of 43 patients, who underwent colonoscopy within 2 weeks before or after MR enterography were evaluated in this retrospective study. DWI sequences, T2-weighted sequences, and contrast-enhanced T1-weighted sequences were acquired in the MR enterography scan after cleaning of the bowel and using an oral contrast agent. Read More

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http://dx.doi.org/10.1097/MD.0000000000019202DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7034637PMC
February 2020

Quantitative evaluation of Crohn's disease using dynamic contrast-enhanced MRI in children and young adults.

Eur Radiol 2020 Jun 20;30(6):3168-3177. Epub 2020 Feb 20.

Department of Radiology, Seoul National University Hospital, 101 Daehak-ro, Jongno-gu, Seoul, 03080, Republic of Korea.

Objectives: To evaluate the clinical usefulness of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) in children and young adults with Crohn's disease.

Methods: From August 2017 to October 2018, 30 patients with Crohn's disease (21 males and 9 females; mean age 15.1 ± 2. Read More

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http://dx.doi.org/10.1007/s00330-020-06684-1DOI Listing
June 2020
4.014 Impact Factor

Observer agreement for small bowel ultrasound in Crohn's disease: results from the METRIC trial.

Abdom Radiol (NY) 2020 Feb 10. Epub 2020 Feb 10.

Centre for Medical Imaging, University College London, London, UK.

Purpose: To prospectively evaluate interobserver agreement for small bowel ultrasound (SBUS) in newly diagnosed and relapsing Crohn's disease.

Methods: A subset of patients recruited to a prospective trial comparing the diagnostic accuracy of MR enterography and SBUS underwent a second SBUS performed by one of a pool of six practitioners, who recorded the presence, activity and location of small bowel and colonic disease. Detailed segmental mural and extra-mural observations were also scored. Read More

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http://dx.doi.org/10.1007/s00261-020-02405-wDOI Listing
February 2020

Crohn's disease activity before and after medical therapy evaluated by MaRIA score and others parameters in MR Enterography.

Clin Imaging 2020 Jun 27;62:1-9. Epub 2020 Jan 27.

Fondazione Policlinico Universitario A. Gemelli IRCCS, UOC di Radiologia Diagnostica e Interventistica Generale, Dipartimento di Diagnostica per Immagini, Radioterapia Oncologica ed Ematologia, Largo Francesco Vito, 1, 00168 Roma, Italy; Università Cattolica del Sacro Cuore, Istituto di Radiologia, Largo Francesco Vito, 1, 00168 Roma, Italy.

Aim: Aim of this retrospective study is to evaluate the response to therapy in Crohn's disease (CD) patients studied by MR Enterography (MRE) in comparison with Harvey Bradshaw Index (HBI).

Methods: One hundred and sixty patients with histological proved CD have undergone MRE in the last years. Forty-six patients who repeated MRE after medical therapy within six months were selected for the study. Read More

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http://dx.doi.org/10.1016/j.clinimag.2020.01.020DOI Listing

Transmural Histological Scoring Systems in Crohn's Disease: A Systematic Review With Assessment of Methodological Quality and Operating Properties.

J Crohns Colitis 2020 Jul;14(6):743-756

Department of Biomedicine, Unit of Pharmacology and Therapeutics, University of Porto, Porto, Portugal.

Background: The relative proportion of inflammation and fibrosis in a stricture is highly relevant in defining the clinical approach for Crohn's disease [CD] patients. Whereas transmural inflammation in CD can be accurately estimated by cross-sectional imaging, evaluating the extent and severity of fibrosis still requires surgical pathology of intestinal resection specimens. This study systematically reviewed all existing transmural histopathological scoring systems developed for the assessment of inflammation and/or fibrosis in CD. Read More

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http://dx.doi.org/10.1093/ecco-jcc/jjz178DOI Listing

Duodenal Crohn's Disease Complicated by Pancreatitis and Common Bile Duct Obstruction.

GE Port J Gastroenterol 2020 Jan 23;27(1):33-36. Epub 2019 May 23.

Gastroenterology Department, Centro Hospitalar de Vila Nova de Gaia e Espinho, Vila Nova de Gaia, Portugal.

Introduction: Crohn's disease (CD) is characterized by segmental and transmural involvement of any portion of the gastrointestinal tract from the mouth to the anus. Duodenal CD is a rare clinical entity, with the majority of the patients being symptomless - its diagnosis requires a high level of clinical suspicion.

Case Presentation: We present the case of a 29-year-old male patient with a 2-month history of weight loss, epigastric pain and postprandial vomiting. Read More

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http://dx.doi.org/10.1159/000499767DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6959094PMC
January 2020

Small Bowel Crohn Disease at CT and MR Enterography: Imaging Atlas and Glossary of Terms.

Radiographics 2020 Mar-Apr;40(2):354-375. Epub 2020 Jan 17.

From the Department of Radiology, Thomas Jefferson University Hospital, 132 S 10th St, Philadelphia, PA 19107 (F.F.G.); Department of Radiology, Thomas Jefferson University Hospital, 132 S 10th St, Philadelphia, PA 19107 (F.F.G.); Department of Radiology, Children's Hospital of Philadelphia and University of Pennsylvania, Philadelphia, Pa (S.A.A., K.D.); Department of Radiology (J.G.F., J.L.F.) and Division of Gastroenterology and Hepatology (D.H.B.), Mayo Clinic, Rochester, Minn.; Department of Radiology, University of Michigan Health System, Ann Arbor, Mich (M.M.A.); Department of Radiology, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio (J.R.D.); Department of Radiology, Rhode Island Hospital, Providence, R.I. (D.J.G.); Department of Radiology, Icahn School of Medicine at Mount Sinai, New York, NY (M.C.); Imaging Institute, Cleveland Clinic, Cleveland, Ohio (N.S.G.); Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, Mass (M.S.G.); Department of Radiology, University of Florida College of Medicine, Gainesville, Fla (J.R.G.); Department of Radiology, New York University Langone Health, New York, N.Y. (C.H.); Department of Radiology, Duke University Medical Center, Durham, N.C. (T.A.J.); Department of Radiology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, South Korea (S.H.P.); Department of Radiology, Hospital Clínic of Barcelona, Barcelona, Spain (J.R.); Department of Radiology, Boston University Medical Center, Boston, Mass (J.A.S.); Department of Radiology, Icahn School of Medicine at Mount Sinai, New York, NY (B.T.); Centre for Medical Imaging, University College London, London, United Kingdom (S.A.T.); and Imaging Institute, Cleveland Clinic, Cleveland, Ohio (M.E.B.).

Representatives from the Society of Abdominal Radiology Crohn's Disease-Focused Panel, the Society for Pediatric Radiology, the American Gastroenterological Association, and other international experts recently reported consensus recommendations for standardized nomenclature for the interpretation and reporting of CT enterography and MR enterography findings of small bowel Crohn disease. The consensus recommendations included CT enterography and MR enterography bowel wall findings that are associated with Crohn disease, findings that occur with penetrating Crohn disease, and changes that occur in the mesentery related to Crohn disease. Also included were recommended radiology report impression statements that summarize the findings of small bowel Crohn disease at CT enterography and MR enterography. Read More

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http://dx.doi.org/10.1148/rg.2020190091DOI Listing
January 2020

Microscopic features of small bowel mucosa of patients with Crohn's disease.

BMC Gastroenterol 2019 Dec 30;19(1):232. Epub 2019 Dec 30.

State Key Laboratory for Oncogenes and Related Genes, Key Laboratory of Gastroenterology and Hepatology, Ministry of Health, Division of Gastroenterology and Hepatology, Shanghai Institute of Digestive Disease, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, 145 Middle Shandong Road, Shanghai, 200001, China.

Background: Double-balloon enteroscopy enables performing numerous small bowel biopsies for pathologic analysis. However, most histopathological characteristics of Crohn's disease are non-specific characteristics. We aimed to explore the small bowel mucosal histopathologic characters of Crohn's disease and identify some disease-specific changes. Read More

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http://dx.doi.org/10.1186/s12876-019-1138-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6937864PMC
December 2019

Comparison of small bowel findings using capsule endoscopy between Crohn's disease and intestinal tuberculosis in Korea.

Yeungnam Univ J Med 2020 Apr 22;37(2):98-105. Epub 2019 Nov 22.

Department of Physiology, Soonchunhyang University College of Medicine, Cheonan, Korea.

Background: Little is known about capsule endoscopy (CE) findings in patients with intestinal tuberculosis who exhibit small bowel lesions. The aim of the present study was to distinguish between Crohn's disease (CD) and intestinal tuberculosis based on CE findings.

Methods: Findings from 55 patients, who underwent CE using PillCam SB CE (Given Imaging, Yoqneam, Israel) between February 2003 and June 2015, were retrospectively analyzed. Read More

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http://dx.doi.org/10.12701/yujm.2019.00374DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7142034PMC

Facing Crohn's: A Rare Association.

Gastroenterology 2020 03 13;158(4):829-830. Epub 2019 Dec 13.

Department of Medicine, Division of Gastroenterology, NYU Langone Health, New York, New York.

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http://dx.doi.org/10.1053/j.gastro.2019.11.300DOI Listing

Enteropathic spondyloarthritis: Results from a large nationwide database analysis.

Autoimmun Rev 2020 Feb 12;19(2):102457. Epub 2019 Dec 12.

Rheumatology, Allergology and Clinical Immunology, Department of Medicina dei Sistemi, University of Rome Tor Vergata, Rome, Italy.

Introduction: Spondyloarthrits (SpA) share clinical, genetic and immunological features with Inflammatory Bowel Diseases (IBD), and enteropathic SpA (eSpA) represent the clinical evidence of the association between gut and joint diseases. This cross-sectional study aimed to report data of eSpA patients collected from the first Italian database.

Patients And Methods: A specific web-based interface has been created to insert and collect the main clinical, serologic and imaging data from patients with eSpA, as well as disease activity, comorbidities and treatment, in a real-life scenario. Read More

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http://dx.doi.org/10.1016/j.autrev.2019.102457DOI Listing
February 2020

Ileocecal thickening: Clinical approach to a common problem.

JGH Open 2019 Dec 22;3(6):456-463. Epub 2019 Apr 22.

Department of Gastroenterology Postgraduate Institute of Medical Education and Research Chandigarh India.

Ileocecal thickening (ICT) is a common finding on radiological imaging. It can be caused by a variety of inflammatory, infectious, or neoplastic conditions, and evaluating a patient of ICT can be a challenging task. Intestinal tuberculosis (ITB), Crohn's disease (CD), and adenocarcinoma are the most common causes. Read More

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http://dx.doi.org/10.1002/jgh3.12186DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6891021PMC
December 2019

Acute Intermittent Porphyria - an Unexpected Association in a Patient with Newly Diagnosed Crohn's Disease.

J Gastrointestin Liver Dis 2019 Dec 9;28(4):509-512. Epub 2019 Dec 9.

Regional Institute of Gastroenterology and Hepatology, Cluj-Napoca, Romania.

The association of Crohn's disease (CD) with acute intermittent porphyria (AIP), both without a family or personal pathological history, is a very rare clinical possibility. We present the case of a 23-year-old male diagnosed on the same admission with ileal CD and with an AIP crisis. The diagnosis was challenging as the symptoms overlapped. Read More

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http://dx.doi.org/10.15403/jgld-547DOI Listing
December 2019

Evaluation of the modified Van Assche index for assessing response to anti-TNF therapy with MRI in perianal fistulizing Crohn's disease.

Clin Imaging 2020 Feb 22;59(2):179-187. Epub 2019 Nov 22.

Amsterdam UMC, University of Amsterdam, Department of Radiology and Nuclear Medicine, Meibergdreef 9, Amsterdam, the Netherlands.

Background: Structured evaluation of magnetic resonance imaging (MRI) is important to guide clinical decisions of perianal fistulas in Crohn's disease (CD) patients.

Purpose: To evaluate the recently developed modified Van Assche index to assess clinical responses to anti-tumor necrosis factor (TNF) therapy in patients with perianal fistulizing CD.

Methods: A search of medical records identified patients with fistulizing perianal CD who underwent baseline and follow-up MRI while receiving anti-TNF treatment. Read More

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http://dx.doi.org/10.1016/j.clinimag.2019.10.007DOI Listing
February 2020
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