4,586 results match your criteria Imaging in Crohn Disease


ANALYSIS OF THE CLINICAL CHARACTERISTICS OF PERIANAL FISTULISING CROHN'S DISEASE IN A SINGLE CENTER.

Arq Bras Cir Dig 2019 Feb 7;32(1):e1420. Epub 2019 Feb 7.

The First Clinical Medical College, Nanjing University of Chinese Medicine, Nanjing, Jiangsu, China.

Background: Clinical characteristics are keys to improve identification and treatment of Crohn´s disease (CD) so that large sample analysis is of great value.

Aim: To explore the clinical characteristics of perianal fistulising CD.

Methods: Analysis of 139 cases focused on their clinical data. Read More

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http://dx.doi.org/10.1590/0102-672020180001e1420DOI Listing
February 2019

MRI reveals different Crohn's disease phenotypes in children and adults.

Eur Radiol 2019 Feb 7. Epub 2019 Feb 7.

Department of Pediatrics and Pediatric Neuropsychiatry, Sapienza University of Rome, Policlinico Umberto I Hospital, Viale del Policlinico, 155, 00161, Rome, Italy.

Objectives: To identify differences between two cohorts of adult and pediatric patients affected by Crohn's disease (CD), with regard to lesion location in the small intestine and colon-rectum, lesion activity, and prevalence of perianal disease (PD), using MRI as the main diagnostic tool.

Methods: We retrospectively reviewed 350 consecutive MRI examinations performed between 2013 and 2016 in outpatients or inpatients with histologically proven CD, monitored by the Gastroenterology and Pediatric Units of our Hospital. The magnetic resonance enterography (MRE) protocol for adult and pediatric CD patients routinely includes evaluation of nine different intestinal segments (from jejunum to rectum) and of the anal canal. Read More

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http://dx.doi.org/10.1007/s00330-019-6006-5DOI Listing
February 2019
1 Read

Does fecal calprotectin equally and accurately measure disease activity in small bowel and large bowel Crohn's disease? - a systematic review.

Intest Res 2019 Feb 7. Epub 2019 Feb 7.

Nottingham Digestive Diseases Centre, University of Nottingham, Nottingham, UK.

Fecal calprotectin (FC) is a highly sensitive disease activity biomarker in inflammatory bowel disease. However, there are conflicting reports on whether the diagnostic accuracy in Crohn's disease is influenced by disease location. The aim of this study was to undertake a systematic review of the published literature. Read More

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http://dx.doi.org/10.5217/ir.2018.00114DOI Listing
February 2019
1 Read

Differentiating Crohn's disease from intestinal tuberculosis.

World J Gastroenterol 2019 Jan;25(4):418-432

Department of Gastroenterology, All India Institute of Medical Sciences, New Delhi 110029, India.

Differentiating Crohn's disease (CD) and intestinal tuberculosis (ITB) has remained a dilemma for most of the clinicians in the developing world, which are endemic for ITB, and where the disease burden of inflammatory bowel disease is on the rise. Although, there are certain clinical (diarrhea/hematochezia/perianal disease common in CD; fever/night sweats common in ITB), endoscopic (longitudinal/aphthous ulcers common in CD; transverse ulcers/patulous ileocaecal valve common in ITB), histologic (caseating/confluent/large granuloma common in ITB; microgranuloma common in CD), microbiologic (positive stain/culture for acid fast-bacillus in ITB), radiologic (long segment involvement/comb sign/skip lesions common in CD; necrotic lymph node/contiguous ileocaecal involvement common in ITB), and serologic differences between CD and ITB, the only exclusive features are caseation necrosis on biopsy, positive smear for acid-fast bacillus (AFB) and/or AFB culture, and necrotic lymph node on cross-sectional imaging in ITB. However, these exclusive features are limited by poor sensitivity, and this has led to the development of multiple multi-parametric predictive models. Read More

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http://dx.doi.org/10.3748/wjg.v25.i4.418DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350172PMC
January 2019
2 Reads

Absence of dentate nucleus resting-state functional connectivity changes in nonneurological patients with gadolinium-related hyperintensity on T -weighted images.

J Magn Reson Imaging 2019 Jan 25. Epub 2019 Jan 25.

Departmental Faculty of Medicine and Surgery, Università Campus Bio-Medico di Roma, Rome, Italy.

Background: The dentate nuclei of the cerebellum are the areas where gadolinium predominantly accumulates. It is not yet known whether gadolinium deposition affects brain functions.

Purpose/hypothesis: To assess whether gadolinium-dependent high signal intensity of the cerebellum on T -weighted images of nonneurological adult patients with Crohn's disease is associated with modifications of resting-state functional connectivity (RSFC) of the cerebellum and dentate nucleus. Read More

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http://dx.doi.org/10.1002/jmri.26669DOI Listing
January 2019
9 Reads

Mitochondrial neurogastrointestinal encephalopathy: a clinicopathological mimic of Crohn's disease.

BMC Gastroenterol 2019 Jan 15;19(1):11. Epub 2019 Jan 15.

Addenbrooke's Hospital, Cambridge University Hospitals NHS Foundation Trust, Cambridge, CB2 0QQ, UK.

Background: Mitochondrial neurogastrointestinal encephalopathy (MNGIE), due to mutations in TYMP, often presents with gastrointestinal symptoms. Two sisters, initially managed for Crohn's disease based upon clinical, imaging and pathological findings, were later found to have MNGIE. The cases provide novel clinicopathological insight, for two further reasons: both sisters remain ambulant and in employment in their late 20s and 30s; diagnosis in one sister was made after a suspected azathioprine-precipitated acute illness. Read More

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http://dx.doi.org/10.1186/s12876-018-0925-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6334462PMC
January 2019
5 Reads

Bowel Ultrasound State of the Art: Grayscale and Doppler Ultrasound, Contrast Enhancement, and Elastography in Crohn Disease.

J Ultrasound Med 2019 Feb 3;38(2):271-288. Epub 2019 Jan 3.

Department of Medicine, Division of Gastroenterology, University of Calgary, Calgary, Alberta, Canada.

Bowel ultrasound (US) is accurate for assessing bowel inflammation and complications in Crohn disease. Additionally, contrast-enhanced US provides a quantitative, objective measurement of inflammatory activity in inflammatory bowel disease, and shear wave elastography predicts the stiffness of bowel, an increase of which suggests less response to medical therapy, often necessitating surgery. Overall, bowel US is an excellent, safe, and repeatable choice for routine surveillance and for urgent imaging. Read More

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http://dx.doi.org/10.1002/jum.14920DOI Listing
February 2019
10 Reads

Backwash ileitis in ulcerative colitis: Are there MR enterographic features that distinguish it from Crohn disease?

Eur J Radiol 2019 Jan 1;110:212-218. Epub 2018 Dec 1.

Department of Internal Medicine, School of Medicine, Ankara University, Talatpaşa Bulvarı, Sıhhiye, 06100 Ankara, Turkey. Electronic address:

Objective: To reveal the MR enterography (MRE) findings that distinguish backwash ileitis (BWI) from terminal ileitis due to Crohn's disease (CD) and to determine the usability of barium studies manifestations (ileocecal valve (ICV) gaping, terminal ileum dilatation) in MRE for the diagnosis of BWI in ulcerative colitis (UC) patients by pointing at the diagnostic performance of these imaging findings.

Subjects-methods: The study population consisted of patients who were diagnosed as ulcerative colitis (UC), and underwent 1.5 T MRI between August 2011 and November 2017 to rule out small bowel involvement. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0720048X183042
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http://dx.doi.org/10.1016/j.ejrad.2018.11.027DOI Listing
January 2019
10 Reads

Differences in the imaging of Crohn's disease patients between North America and Europe: are we ready to bridge the divide?

Abdom Radiol (NY) 2018 Dec 22. Epub 2018 Dec 22.

Department of Radiology, Mayo Clinic, 200 First St SW, Rochester, MN, 55905, USA.

The emphasis of treatment in Crohn's disease has evolved from a reactive model to "treat-to-target" approaches. Cross-sectional imaging has rapidly evolved in parallel, with a growing evidence base supporting its abilities for diagnosis, monitoring and prognostication. Whilst there are differences in emphasis between Europe and North America, particularly around the type of imaging modalities and patterns of multidisciplinary care, there is increasing convergence. Read More

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http://dx.doi.org/10.1007/s00261-018-1872-xDOI Listing
December 2018
2 Reads

Does MR enterography offer added value after a recent CT in the evaluation of abdominal pain in Crohn's disease patients?

Clin Imaging 2018 Dec 10;54:78-83. Epub 2018 Dec 10.

Yale New Haven Hospital, Department of Radiology and Biomedical Imaging, 20 York Street, New Haven, CT 06520, United States of America. Electronic address:

Purpose: To determine if there is added value in performing MR enterography shortly after a contrast-enhanced CT of the abdomen and pelvis in patients with Crohn's disease presenting with acute abdominal pain.

Materials And Methods: A total of 45 consecutive patients who underwent MRE examination <7 days after a CT met our strict inclusion criteria. Independent and blinded review of both MRE and CT exams was performed by two abdominal radiologists. Read More

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http://dx.doi.org/10.1016/j.clinimag.2018.12.002DOI Listing
December 2018
2 Reads

IVIM with fractional perfusion as a novel biomarker for detecting and grading intestinal fibrosis in Crohn's disease.

Eur Radiol 2018 Dec 13. Epub 2018 Dec 13.

Department of Radiology, The First Affiliated Hospital, Sun Yat-Sen University, 58 Zhongshan II Road, Guangzhou, 510080, People's Republic of China.

Objectives: Intravoxel incoherent motion (IVIM) diffusion-weighted magnetic resonance imaging (MRI) provides information on both perfusion and diffusion and has been used to evaluate Crohn's disease (CD) activity and fibrosis in children; however, there are no reports on its use in adults. We aimed to determine its value for detecting and grading intestinal fibrosis in adults with CD compared with contrast-enhanced imaging and traditional diffusion-weighted imaging using surgical histopathology as a reference standard.

Methods: Twenty-four adults with CD underwent preoperative IVIM, traditional diffusion-weighted, and contrast-enhanced imaging. Read More

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http://dx.doi.org/10.1007/s00330-018-5848-6DOI Listing
December 2018
1 Read
4.014 Impact Factor

Fetal distress and urgent cesarean delivery due to new-onset peripartum Crohn's disease.

Taiwan J Obstet Gynecol 2018 Dec;57(6):901-902

Department of Gastroenterology, Shaare Zedek Medical Center, Hebrew University Medical School of Jerusalem, Jerusalem, Israel.

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http://dx.doi.org/10.1016/j.tjog.2018.10.025DOI Listing
December 2018

Comparison of MRI Activity Scoring Systems and Features for the Terminal Ileum in Patients With Crohn Disease.

AJR Am J Roentgenol 2019 Feb 12;212(2):W25-W31. Epub 2018 Dec 12.

1 Department of Radiology and Nuclear Medicine, Amsterdam UMC, University of Amsterdam, Meibergdreef 9, 1105AZ, Amsterdam, The Netherlands.

Objective: The purpose of this study was to evaluate four previously validated MRI activity scoring systems for diagnosis and grading of Crohn disease (CD) in the terminal ileum against an endoscopic and histopathologic reference standard.

Subjects And Methods: Ethics approval and written informed consent were obtained. Subjects with known or suspected CD were prospectively recruited between December 2011 and August 2014. Read More

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https://www.ajronline.org/doi/10.2214/AJR.18.19876
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http://dx.doi.org/10.2214/AJR.18.19876DOI Listing
February 2019
10 Reads

The role of intravenous Contrast Agent in the Sonographic Assessment of Crohn's Disease Activity: Is Contrast Agent Injection Necessary?

J Crohns Colitis 2018 Dec 8. Epub 2018 Dec 8.

Department of Radiology, Valencia (SPAIN).

Background: the literature shows that contrast-enhanced ultrasound (CEUS) is superior to wall thickness or color Doppler imaging (CDI) in predicting disease activity using endoscopy as the reference standard.

Objective: to determine in patients with Crohn´s disease (CD) whether the evaluation of wall thickness or CDI before CEUS examination could help decide when the injection of contrast agent is justified as a means for detecting disease activity as determined at endoscopy, without reducing the accuracy of ultrasound.

Material & Methods: 180 patients with CD underwent both colonoscopy and US, including mural thickness, CDI and CEUS evaluation, prospectively as part of clinical care. Read More

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http://dx.doi.org/10.1093/ecco-jcc/jjy204DOI Listing
December 2018
1 Read

Fecal calprotectin correlates with active colonic inflammatory bowel disease but not with small intestinal Crohn's disease activity.

JGH Open 2018 Oct 17;2(5):201-206. Epub 2018 Jul 17.

Division of Gastroenterology, Department of Medicine, Zane Cohen Center, Mount Sinai Hospital University of Toronto Toronto Ontario Canada.

Background: The utility of fecal calprotectin (FC) in small intestinal Crohn's disease (CD) is unclear. We examined how reliably FC reflects clinical and mucosal disease activity in small intestinal CD, colonic CD, and ulcerative colitis (UC).

Methods: A total of 72 Inflammatory Bowel Disease (IBD) patients (23 colonic CD, 14 isolated small intestinal CD, and 35 UC) were included. Read More

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http://dx.doi.org/10.1002/jgh3.12068DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6207015PMC
October 2018
11 Reads

An acute neurological complication of Crohn's disease.

Funct Neurol 2018 Jul/Sept;33(3):165-166

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November 2018
3 Reads

Ultrasound findings in extragenital endometriosis.

J Ultrason 2018 ;18(74):247-254

Medizinische Klinik 2, Caritas-Krankenhaus Bad Mergentheim, Bad Mergentheim, Germany.

We present a report on ultrasound findings in extragenital endometriosis and a literature review accompanied by illustrations. Intestinal endometriosis should be considered in female patients of reproductive age who present with constipation, gastrointestinal bleeding, nausea, vomiting, cramp-like abdominal pain, diarrhoea and pelvic pain. Although definitive preoperative diagnosis of endometriosis is difficult, clinical suspicion and appropriate imaging might prevent extensive surgical procedures with higher morbidity. Read More

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http://jultrason.pl/index.php/issues/volume-18-no-74/ultraso
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http://dx.doi.org/10.15557/JoU.2018.0036DOI Listing
January 2018
12 Reads

Paediatric bowel ultrasound in inflammatory bowel disease.

Eur J Radiol 2018 Nov 10;108:21-27. Epub 2018 Sep 10.

Department of Imaging, Royal Free Hospital, Royal Free London NHS Foundation Trust, London, UK.

Ultrasound has long been favoured as first line when imaging children, primarily due to it being a non-invasive, relatively low cost, easily accessible modality. The many advantages of ultrasound evaluation in paediatric inflammatory bowel disease (IBD) vastly outweighs its limitations in both initial assessment and long term follow up. High frequency ultrasound provides excellent spatial resolution, and Doppler evaluation and compression sonography aids in providing real-time dynamic assessment in IBD where other modalities cannot. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0720048X183030
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http://dx.doi.org/10.1016/j.ejrad.2018.09.004DOI Listing
November 2018
10 Reads

Curved planar reformatting and convolutional neural network-based segmentation of the small bowel for visualization and quantitative assessment of pediatric Crohn's disease from MRI.

J Magn Reson Imaging 2018 Oct 24. Epub 2018 Oct 24.

Computational Radiology Laboratory, Department of Radiology, Children's Hospital Boston, Harvard Medical School, Boston, Massachusetts, USA.

Background: Contrast-enhanced MRI of the small bowel is an effective imaging sequence for the detection and characterization of disease burden in pediatric Crohn's disease (CD). However, visualization and quantification of disease burden requires scrolling back and forth through 3D images to follow the anatomy of the bowel, and it can be difficult to fully appreciate the extent of disease.

Purpose: To develop and evaluate a method that offers better visualization and quantitative assessment of CD from MRI. Read More

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http://dx.doi.org/10.1002/jmri.26330DOI Listing
October 2018
5 Reads

Coronary artery ectasia in Crohn's disease.

BMJ Case Rep 2018 Oct 21;2018. Epub 2018 Oct 21.

Third Department of Cardiology, Hygeia Hospital, Athens, Attica, Greece.

Coronary artery ectasia (CAE) can be ascribed, in the majority of cases, to coronary atherosclerosis. Nevertheless, the presence of isolated ectatic lesions without obstructive coronary artery disease and the association of CAE with several autoimmune diseases characterised by systemic vascular involvement suggest that the pathogenesis of CAE may extend beyond coronary atherosclerosis. We herein report the case of a 56-year-old male patient with Crohn's disease and isolated CAE, who has been found positive for IgM and IgA antiendothelial cell antibodies, and discuss a potential pathogenic mechanism. Read More

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http://dx.doi.org/10.1136/bcr-2018-226813DOI Listing
October 2018

The Clinical and Cost-Effectiveness of 4 Enzyme-Linked Immunosorbent Assay Kits for Monitoring Infliximab in Crohn Disease Patients: Protocol for a Validation Study.

JMIR Res Protoc 2018 Oct 19;7(10):e11218. Epub 2018 Oct 19.

Department of Gastroenterology, Guy's & St Thomas' National Health Service Trust, London, United Kingdom.

Background: Currently, treatment decisions for people with Crohn disease are based on clinical judgment and trial and error. Consequently, people may continue to receive high drug dosages and experience unnecessary toxicity when it is possible to reduce or discontinue without a detrimental effect on clinical outcomes. Therapeutic drug monitoring (TDM) involves regularly testing blood samples for drug and antibody levels that could help clinicians identify the optimal treatment strategy and pre-empt treatment failure. Read More

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http://www.researchprotocols.org/2018/10/e11218/
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http://dx.doi.org/10.2196/11218DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6231806PMC
October 2018
9 Reads

Reduced Imaging Radiation Exposure and Costs Associated with Anti-Tumor Necrosis Factor Therapy in Crohn's Disease.

Dig Dis Sci 2019 01 11;64(1):60-67. Epub 2018 Oct 11.

University of Maryland, 685 W. Baltimore St., Suite 8-00, Baltimore, MD, 21201, USA.

Background: Radiation exposure from diagnostic imaging may increase cancer risk of Crohn's disease (CD) patients, who are already at increased risk of certain cancers.

Aim: To compare imaging radiation exposure and associated costs in CD patients during the year pre- and post-initiation of anti-tumor necrosis factor (anti-TNF) agents or corticosteroids.

Methods: Adults were identified from a large US claims database between 1/1/2005 and 12/31/2009 with ≥ 1 abdominal imaging scan and 12 months of enrollment before and after initiating therapy with anti-TNF or corticosteroids. Read More

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http://dx.doi.org/10.1007/s10620-018-5322-yDOI Listing
January 2019
5 Reads

Ram's Horn Sign: Gastric antrum in Crohn's disease.

J Med Imaging Radiat Oncol 2018 Oct;62 Suppl 1:101

Department of Radiology, Concord Repatriation General Hospital, Concord, New South Wales, Australia.

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http://dx.doi.org/10.1111/1754-9485.45_12784DOI Listing
October 2018
1 Read

Cerebral granulomatosis as a manifestation of Crohn's disease.

BMC Neurol 2018 Oct 3;18(1):161. Epub 2018 Oct 3.

Department of Neurology and Neuroscience, Medical Center, University of Freiburg, Breisacher Straße 64, D-79106, Freiburg, Germany.

Background: Crohn's disease (CD) is associated with a variety of extra-intestinal manifestations. Most commonly these involve the eye, skin, joints, coagulation system and liver. Cerebral manifestations of CD have been reported to a far lesser extent. Read More

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http://dx.doi.org/10.1186/s12883-018-1163-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6169107PMC
October 2018
11 Reads

Posterior Reversible Encephalopathy Syndrome following Ustekinumab Induction for Crohn's Disease.

Case Rep Gastroenterol 2018 May-Aug;12(2):521-527. Epub 2018 Aug 29.

Division of Gastroenterology and Hepatology, Rutgers-Robert Wood Johnson Medical School, New Brunswick, New Jersey, USA.

Biological agents are frequently used in the management of inflammatory bowel disease, and it is important to understand the potential adverse effects of these therapies. Ustekinumab is a human monoclonal antibody that interferes with interleukin-12 and -23 cytokine signaling and is approved for the treatment of moderate to severe Crohn's disease. We report 2 cases of neurological adverse events, one of which is consistent with posterior reversible encephalopathy syndrome (PRES), in the setting of ustekinumab therapy for Crohn's disease. Read More

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http://dx.doi.org/10.1159/000492462DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6167711PMC
August 2018
13 Reads

Creeping Fat Assessed by Small Bowel MRI Is Linked to Bowel Damage and Abdominal Surgery in Crohn's Disease.

Dig Dis Sci 2019 01 1;64(1):204-212. Epub 2018 Oct 1.

Department of Gastroenterology and Hepatology, Berufsgenossenschaftliches Universitätsklinikum Bergmannsheil gGmbH, Ruhr-University Bochum, Bürkle-de-la-Camp-Platz 1, 44789, Bochum, Germany.

Background: Crohn's disease (CD) leads to bowel damage and surgery in a significant proportion of patients.

Aims: The aim of the study was to evaluate the predictive value of creeping fat assessed by small bowel MRI in CD patients.

Methods: CD patients undergoing small bowel MRI were included in a retrospective observational cohort study. Read More

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http://dx.doi.org/10.1007/s10620-018-5303-1DOI Listing
January 2019
4 Reads

Neurotransmitter alterations in the anterior cingulate cortex in Crohn's disease patients with abdominal pain: A preliminary MR spectroscopy study.

Neuroimage Clin 2018 18;20:793-799. Epub 2018 Sep 18.

Department of Radiology, The First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, China. Electronic address:

Purpose: Crohn's disease (CD) has been known to cause both abdominal pain alongside functional and structural alterations in the central nervous system (CNS) in affected patients. This study seeks to determine the alternations of metabolites in the bilateral anterior cingulate cortex (ACC) of CD patients with abdominal pain by using proton magnetic resonance spectroscopy (H-MRS) to further explore the neural mechanism.

Methods: Sixteen CD patients with abdominal pain and 13 CD patients without abdominal pain, were recruited alongside 20 healthy controls (HCs) for this study. Read More

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http://dx.doi.org/10.1016/j.nicl.2018.09.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6169252PMC
January 2019
3 Reads

Management of inflammatory bowel disease.

Med J Aust 2018 Sep;209(7):318-323

St Vincent's Hospital Melbourne, Melbourne, VIC.

Australia has one of the highest incidence rates of inflammatory bowel disease (IBD) in the world. Early diagnosis and treatment for IBD is critical. For Crohn disease, in particular, this may change the natural history of disease and reduce disability. Read More

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September 2018
6 Reads

When IBD is not IBD.

Scand J Gastroenterol 2018 Sep 26;53(9):1085-1088. Epub 2018 Sep 26.

a Department of Gastroenterology and Hepatology , University Hospitals Leuven, KU Leuven , Leuven , Belgium.

Entamoeba histolytica colitis can mimic Crohn's disease. However, a fulminant infection can be life-threatening, especially after exposure to systemic steroids. We present a case of the patient who was initially diagnosed with ileocolonic Crohn's disease, but developed a hepatic E histolytica abscess while undergoing anti-TNF therapy. Read More

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http://dx.doi.org/10.1080/00365521.2018.1500637DOI Listing
September 2018
15 Reads

Daikenchuto (Da-Jian-Zhong-Tang) ameliorates intestinal fibrosis by activating myofibroblast transient receptor potential ankyrin 1 channel.

World J Gastroenterol 2018 Sep;24(35):4036-4053

Department of Physiology, Graduate School of Medical Sciences, Fukuoka University, Fukuoka 8140180, Japan.

Aim: To investigate the anti-fibrotic effects of the traditional oriental herbal medicine Daikenchuto (DKT) associated with transient receptor potential ankyrin 1 (TRPA1) channels in intestinal myofibroblasts.

Methods: Inflammatory and fibrotic changes were detected in a 2,4,6-trinitrobenzenesulfonic acid (TNBS) chronic colitis model of wild-type and TRPA1-knockout (TRPA1-KO) mice pathological staining and immunoblotting analysis. Ca imaging experiments examined the effects of DKT and its components/ingredients on intestinal myofibroblast (InMyoFib) cell TRPA1 channel function. Read More

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http://dx.doi.org/10.3748/wjg.v24.i35.4036DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6148431PMC
September 2018
5 Reads

Endoscopy in inflammatory bowel disease: Role in diagnosis, management, and treatment.

World J Gastroenterol 2018 Sep;24(35):4014-4020

Division of Gastroenterology and Hepatology, University of North Carolina, Charlotte, NC 28204, United States.

Endoscopy plays a fundamental role in the diagnosis, management, and treatment of inflammatory bowel disease (IBD). Colonoscopy, flexible sigmoidoscopy, and esophagogastroduodenoscopy have long been used in the care of patients with IBD. As endoscopic technologies have progressed, tools such as endoscopic ultrasound, capsule endoscopy, and balloon-assisted enteroscopy have expanded the role of endoscopy in IBD. Read More

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http://dx.doi.org/10.3748/wjg.v24.i35.4014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6148432PMC
September 2018
14 Reads

Treatment of Active Crohn's Disease with Exclusive and Partial Enteral Nutrition: A Pilot Study in Adults.

Inflamm Intest Dis 2018 Jul 26;2(4):219-227. Epub 2018 Jun 26.

Department of Paediatrics, University of Otago Christchurch, Christchurch, New Zealand.

Background And Aim: Enteral nutrition (EN) is not commonly used for the treatment of adults with active Crohn's disease (CD), despite patient interest in nutrition-based alternatives to corticosteroids and evidence of efficacy in paediatric CD. The aim of this study was to assess the impact of 2 different EN regimens on disease symptoms, nutrition and inflammatory markers in young adults with active CD.

Methods: A prospective non-randomized pilot study of adults aged 16-40 years with active CD on endoscopy or imaging was undertaken. Read More

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http://dx.doi.org/10.1159/000489630DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6135224PMC

Imaging and Surgical Management of Anorectal Vaginal Fistulas.

Radiographics 2018 Sep-Oct;38(5):1385-1401

From the Department of Radiology (W.M.V., S.P.S., M.C.W., J.G.F.), Department of Surgery (A.L.L.), and School of Medicine (S.T.K.), Mayo Clinic, 200 First St SW, Rochester, MN 55905; and Department of Radiology, Mayo Clinic, Scottsdale, Ariz (C.O.M.).

Anorectal vaginal fistulas (ARVFs) can result in substantial morbidity and potentially embarrassing symptoms in adult women of all ages. Despite having what may be obvious clinical manifestations, the fistulas themselves can be difficult to identify with imaging. MRI is the modality of choice for the diagnosis and characterization of ARVFs. Read More

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http://dx.doi.org/10.1148/rg.2018170167DOI Listing
December 2018
3 Reads

[Intraperitoneal cystic lymphangioma and Crohn's disease: an exceptional association].

Pan Afr Med J 2018 18;30:48. Epub 2018 May 18.

Service de Gastroentérologie A, Hôpital la Rabta, Tunis, Tunisie.

Cystic lymphangioma is a rare benign malformative tumor of the lymphatic vessels which may occur in various locations. Intra-abdominal cystic lymphangioma is less frequent than cervicoaxillary cystic lymphangioma. Clinical presentation is polymorphic. Read More

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http://dx.doi.org/10.11604/pamj.2018.30.48.14601DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6125285PMC
September 2018
2 Reads

From bench to bedside: Fecal calprotectin in inflammatory bowel diseases clinical setting.

World J Gastroenterol 2018 Sep;24(33):3681-3694

Department of General Surgery and Gastroenterology, Gastroenterology Unit, Azienda Ospedaliero Universitaria Pisana, Pisa 56124, Italy.

Fecal calprotectin (FC) has emerged as one of the most useful tools for clinical management of inflammatory bowel diseases (IBD). Many different methods of assessment have been developed and different cut-offs have been suggested for different clinical settings. We carried out a comprehensive literature review of the most relevant FC-related topics: the role of FC in discriminating between IBD and irritable bowel syndrome (IBS) and its use in managing IBD patients In patients with intestinal symptoms, due to the high negative predictive value a normal FC level reliably rules out active IBD. Read More

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http://www.wjgnet.com/1007-9327/full/v24/i33/3681.htm
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http://dx.doi.org/10.3748/wjg.v24.i33.3681DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6127662PMC
September 2018
17 Reads

Visceral fat area measured with computed tomography does not predict postoperative course in Crohn´s disease patients.

PLoS One 2018 22;13(8):e0202220. Epub 2018 Aug 22.

Department of Surgery, Medical University of Vienna, Vienna, Austria.

The role of visceral fat measured by computer tomography is yet not well defined in patients with Crohn's disease. Therefore, the present study was designed to assess the impact of visceral fat area on postoperative short-term outcome and surgical characteristics. We analyzed 95 patients, who underwent intestinal resection for symptomatic Crohn's disease at an academic tertiary referral center between 2003 and 2008. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0202220PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6104989PMC
August 2018
1 Read

Quantified Terminal Ileal Motility during MR Enterography as a Biomarker of Crohn Disease Activity: Prospective Multi-Institution Study.

Radiology 2018 Nov 21;289(2):428-435. Epub 2018 Aug 21.

From the Centre for Medical Imaging, University College London, Charles Bell House, 43-45 Foley Street, 2nd Floor, London W1W 7TS, England (A.M., A.A.P., J.M., D.P., D.A., G.B., S.A.T.) and Department of Histopathology/Research Pathology, University College London Hospitals/University College London Cancer Institute, Rockefeller Building, 21 University Street, London WC1E 6DE, England (M.R.J.); Department of Radiology and Nuclear Medicine, Academic Medical Center, Amsterdam, the Netherlands (C.P., C.E.T.N., J.T., F.V., J.S.); Department of Pathology, UMC Utrecht, Utrecht, the Netherlands (L.A.B.); and Department of Quantitative Imaging, Technical University Delft, Delft, the Netherlands (F.V.).

Purpose To evaluate the accuracy of MRI-quantified small bowel motility for Crohn disease activity against endoscopic and histopathologic reference standards. Materials and Methods For this prospective study, 82 participants (median age, 31 years; range, 16 to 70 years; 42 males [median age, 31 years; range, 17 to 70 years] and 40 females [median age, 31 years; range, 16 to 63 years) underwent colonoscopy and MR enterography within 14 days (from October 2011 to March 2014) at two centers. The Crohn disease endoscopic index of severity (CDEIS), histopathologic activity score (endoscopic biopsy acute histologic inflammatory score [EAIS]), and MR index of activity (MaRIA) were scored in the terminal ileum. Read More

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http://dx.doi.org/10.1148/radiol.2018180100DOI Listing
November 2018
11 Reads

Magnetic resonance enterography, small bowel ultrasound and colonoscopy to diagnose and stage Crohn's disease: patient acceptability and perceived burden.

Eur Radiol 2019 Mar 20;29(3):1083-1093. Epub 2018 Aug 20.

Centre for Medical Imaging, University College London, Charles Bell House, 43-45, Foley Street, London, W1W 7TS, UK.

Objectives: To compare patient acceptability and burden of magnetic resonance enterography (MRE) and ultrasound (US) to each other, and to other enteric investigations, particularly colonoscopy.

Methods: 159 patients (mean age 38, 94 female) with newly diagnosed or relapsing Crohn's disease, prospectively recruited to a multicentre diagnostic accuracy study comparing MRE and US completed an experience questionnaire on the burden and acceptability of small bowel investigations between December 2013 and September 2016. Acceptability, recovery time, scan burden and willingness to repeat the test were analysed using the Wilcoxon signed rank and McNemar tests; and group differences in scan burden with Mann-Whitney U and Kruskal-Wallis tests. Read More

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http://dx.doi.org/10.1007/s00330-018-5661-2DOI Listing
March 2019
4 Reads

Inter-radiologist agreement using Society of Abdominal Radiology-American Gastroenterological Association (SAR-AGA) consensus nomenclature for reporting CT and MR enterography in children and young adults with small bowel Crohn disease.

Abdom Radiol (NY) 2018 Aug 17. Epub 2018 Aug 17.

Department of Radiology, Cincinnati Children's Hospital Medical Center, 3333 Burnet Ave, Cincinnati, OH, 45229, USA.

Purpose: To assess inter-radiologist agreement using the Society of Abdominal Radiology-American Gastroenterological Association (SAR-AGA) consensus recommendations for reporting CT/MR enterography exams in pediatric and young adult small bowel Crohn disease (CD).

Methods: Institutional review board approval was obtained for this HIPAA-compliant retrospective investigation; the requirement for informed consent was waived. 25 CT and 25 MR enterography exams performed in children and young adults (age range: 6-23 years) between January 2015 and April 2017 with a distribution of ileal CD severity (phenotype) were identified: normal or chronic CD without active inflammation (40%), active inflammatory CD (20%), stricturing CD (20%), and penetrating CD (20%). Read More

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http://dx.doi.org/10.1007/s00261-018-1743-5DOI Listing
August 2018
2 Reads

Interdisciplinary Updates in Crohn's Disease Reporting Nomenclature, and Cross-Sectional Disease Monitoring.

Radiol Clin North Am 2018 Sep;56(5):691-707

Division of Gastroenterology and Hepatology, Department of Internal Medicine, Mayo Clinic, 200 First Street Southwest, Rochester, MN 55905, USA.

Computed tomography enterography and magnetic resonance enterography are essential in the evaluation and treatment of patients with Crohn's disease. As such, examination reporting must use standardized nomenclature for effective communication. This report documents an interdisciplinary consensus of the Society of Abdominal Radiology, the Society of Pediatric Radiology, and the American Gastroenterology Association on the computed tomography enterography/magnetic resonance enterography imaging findings and imaging-based morphologic phenotypes. Read More

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http://dx.doi.org/10.1016/j.rcl.2018.04.010DOI Listing
September 2018

Magnetic Resonance Enterography for Inflammatory and Noninflammatory Conditions of the Small Bowel.

Radiol Clin North Am 2018 Sep 11;56(5):671-689. Epub 2018 Jul 11.

Department of Radiology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA. Electronic address:

Magnetic resonance enterography (MRE) is an effective noninvasive tool for evaluation of inflammatory and noninflammatory conditions of the small bowel. MRE allows for repeated evaluation of patients with Crohn disease without exposure to ionizing radiation, and can be used to assess disease status and direct management. MRE also allows evaluation of neoplastic and other nonneoplastic conditions of the small bowel. Read More

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http://dx.doi.org/10.1016/j.rcl.2018.04.003DOI Listing
September 2018
3 Reads

Computed Tomography and Magnetic Resonance Small Bowel Enterography: Current Status and Future Trends Focusing on Crohn's Disease.

Gastroenterol Clin North Am 2018 Sep 7;47(3):475-499. Epub 2018 Jul 7.

Department of Radiology, Mayo Clinic, 200 First Street, Southwest, Rochester, MN 55905, USA.

Computed tomography enterography (CTE) and magnetic resonance enterography (MRE) are presently state-of-the-art radiologic tests used to examine the small bowel for various indications. This article focuses on CTE and MRE for the evaluation of Crohn disease. The article describes recent efforts to achieve more standardized interpretation of CTE and MRE, summarizes recent research studies investigating the role and impact of CTE and MRE more directly for several different clinical and research issues beyond general diagnostic accuracy, and provides an update on progress in imaging techniques. Read More

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http://dx.doi.org/10.1016/j.gtc.2018.04.002DOI Listing
September 2018
7 Reads

Comparison of contrast-enhanced and diffusion-weighted MRI in assessment of the terminal ileum in Crohn's disease patients.

Abdom Radiol (NY) 2018 Aug 14. Epub 2018 Aug 14.

Department of Radiology and Nuclear Medicine, Amsterdam UMC, University of Amsterdam, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands.

Purpose: The purpose of the study was to compare the performance of contrast-enhanced (CE)-MRI and diffusion-weighted imaging (DW)-MRI in grading Crohn's disease activity of the terminal ileum.

Methods: Three readers evaluated CE-MRI, DW-MRI, and their combinations (CE/DW-MRI and DW/CE-MRI, depending on which protocol was used at the start of evaluation). Disease severity grading scores were correlated to the Crohn's Disease Endoscopic Index of Severity (CDEIS). Read More

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http://dx.doi.org/10.1007/s00261-018-1734-6DOI Listing
August 2018
9 Reads

Standardization of mesenchymal stromal cell therapy for perianal fistulizing Crohn's disease.

Eur J Gastroenterol Hepatol 2018 10;30(10):1148-1154

Surgery, Leiden University Medical Center, Leiden, The Netherlands.

Background: Local administration of mesenchymal stromal cells (MSCs) into the fistula tract seems to improve patient outcome in perianal fistulas due to Crohn's disease (CD). In this paper we propose a standardized and validated protocol for the local administration of MSCs for CD perianal fistulas to be able to reliably assess efficacy.

Materials And Methods: A working group consisting of gastroenterologists and surgeons with expertise in the treatment of perianal CD developed a consensus perianal fistula treatment protocol for local MSC treatment of perianal fistulizing CD. Read More

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http://dx.doi.org/10.1097/MEG.0000000000001208DOI Listing
October 2018
10 Reads

Intestinal Behçet Disease: Evaluation With MR Enterography-A Case-Control Study.

AJR Am J Roentgenol 2018 Oct 7;211(4):767-775. Epub 2018 Aug 7.

2 Department of Internal Medicine-Rheumatology, School of Medicine, Ankara University, Ankara, Turkey.

Objective: The purposes of this study were to discern imaging findings that distinguish Behçet disease from small-bowel Crohn disease, to find initial performance estimates for these findings, and to evaluate the diagnostic value of MR enterography (MRE) for detecting intestinal Behçet disease.

Materials And Methods: The MRE examinations of 30 consecutively registered patients with established intestinal Behçet disease were reviewed by two blinded readers. The frequencies of MRE findings were compared with those obtained for 30 control subjects with small-bowel Crohn disease who were matched for sex and age. Read More

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http://dx.doi.org/10.2214/AJR.17.19174DOI Listing
October 2018
7 Reads

Magnetic resonance enterography evaluation of Crohn disease activity and mucosal healing in young patients.

Pediatr Radiol 2018 08 4;48(9):1273-1279. Epub 2018 Aug 4.

Department of Radiology, Division of Abdominal Imaging, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.

MR enterography (MRE) has become the primary imaging modality for assessing Crohn disease in young patients because of its lack of ionizing radiation, superior soft-tissue contrast, and cross-sectional capability to evaluate disease activity as well as extraluminal and extra-intestinal complications. MRE has been extensively validated against both histological and endoscopic references as a noninvasive imaging biomarker of Crohn disease activity. More recent studies have also validated MRE as a noninvasive biomarker of mucosal healing, an important endpoint of Crohn disease therapy. Read More

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http://dx.doi.org/10.1007/s00247-018-4107-yDOI Listing
August 2018
2 Reads

Persistent Enhancement on Contrast-Enhanced Ultrasound Studies of Severe Crohn's Disease: Stuck Bubbles?

Ultrasound Med Biol 2018 11 31;44(11):2189-2198. Epub 2018 Jul 31.

Department of Radiology, University of Calgary, Calgary, Alberta, Canada; Department of Medicine, Division of Gastroenterology, University of Calgary, Calgary, Alberta, Canada. Electronic address:

A small population of patients with severe Crohn's disease (CD) exhibit atypical lack of intensity decline on intestinal contrast-enhanced ultrasound. From a retrospective CD cohort examined with contrast-enhanced ultrasound, 104 patients were identified. Twenty study patients with severe active disease exhibited high peak enhancement (>23 dB) and minimal decline. Read More

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http://dx.doi.org/10.1016/j.ultrasmedbio.2018.06.018DOI Listing
November 2018

Assessment of normal jejunum with diffusion-weighted imaging on MRE in children.

Pediatr Radiol 2018 11 31;48(12):1763-1770. Epub 2018 Jul 31.

Department of Radiology, The Children's Hospital of Philadelphia, 3401 Civic Center Blvd., Philadelphia, PA, 19104, USA.

Background: Diffusion restriction has been utilized as a marker for bowel inflammation on magnetic resonance enterography (MRE). However, diffusion restriction has been seen in otherwise normal appearing small bowel in patients without active inflammation, with little published data on this subject.

Objective: Assess diffusion restriction in normal loops of jejunum and to determine if there is a correlation to luminal distention, age, magnet field strength, slice thickness, and bowel segment location. Read More

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http://dx.doi.org/10.1007/s00247-018-4200-2DOI Listing
November 2018
3 Reads

Creeping fat in patients with ileo-colonic Crohn's disease correlates with disease activity and severity of inflammation: A preliminary study using energy spectral computed tomography.

J Dig Dis 2018 Aug 9;19(8):475-484. Epub 2018 Sep 9.

Department of Radiology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.

Objective: To investigate the relationship between creeping fat and inflammatory activity as well as the prognosis of ileo-colonic Crohn's disease (CD), based on a quantitative analysis of energy spectral computed tomography (CT).

Methods: A total of 40 patients with CD and 40 with other gastrointestinal diseases who underwent an energy spectral CT scanning between March 2014 and March 2015 were retrospectively enrolled. The endoscopic severity of CD was evaluated by the simple endoscopic score for Crohn's disease (SES-CD). Read More

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http://dx.doi.org/10.1111/1751-2980.12652DOI Listing
August 2018
12 Reads

Advanced parametric imaging for evaluation of Crohn's disease using dual-energy computed tomography enterography.

Radiol Case Rep 2018 Jun 24;13(3):709-712. Epub 2018 Apr 24.

Department of Diagnostic Radiology, Faculty of Life Sciences, Kumamoto University, 1-1-1 Honjyo, Chuo-ku, Kumamoto, 860-8556, Japan.

We describe a case of small bowel Crohn's disease in which dual-energy computed tomography enterography using dual-layer spectral detector scanner contributed to quantitative assessment, and provided a higher degree of confidence pertaining to the diagnosis. Dual-layer spectral detector computed tomography enables retrospective analysis including virtual monochromatic imaging, iodine mapping, and determining the effective atomic number Z with routine scan protocols. These advanced parametric dual-energy imaging holds promising potential as an imaging biomarker for diagnosis, risk-stratification, monitoring of disease progression and therapy, and outcome prediction. Read More

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http://dx.doi.org/10.1016/j.radcr.2018.04.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6057867PMC
June 2018
1 Read