5,609 results match your criteria Imaging in Crohn Disease

Differentially Expressed miRNAs in Ulcerative Colitis and Crohn's Disease.

Front Immunol 2022 6;13:865777. Epub 2022 Jun 6.

Translational Type 1 Diabetes Research, Department of Clinical Research, Steno Diabetes Center Copenhagen, Gentofte, Denmark.

Differential microRNA (miRNA or miR) regulation is linked to the development and progress of many diseases, including inflammatory bowel disease (IBD). It is well-established that miRNAs are involved in the differentiation, maturation, and functional control of immune cells. miRNAs modulate inflammatory cascades and affect the extracellular matrix, tight junctions, cellular hemostasis, and microbiota. Read More

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Clinical utility of small bowel ultrasound assessment of Crohn's disease in adults: a systematic scoping review.

Frontline Gastroenterol 2022 23;13(4):280-286. Epub 2021 Jun 23.

NIHR Nottingham Biomedical Research Centre-Gastrointestinal and Liver Research Theme, School of Medicine, Nottingham, UK.

Background: Ultrasound (US) is an alternative to magnetic resonance enterography, and has the potential to significantly reduce waiting times, expedite clinical decision-making and improve patient experience. Point of care US is an advantage of the US imaging modality, where same day scanning, interpretation and treatment decisions can be made.

Aim: To systematically scope the literature on point of care US use in small bowel Crohn's disease, generating a comprehensive list of factors relating to the current understanding of clinical utility of this imaging modality. Read More

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Occult small bowel adenocarcinoma in a Crohn disease stricture.

Intern Med J 2022 Jun;52(6):1093-1094

Department of Gastroenterology and Hepatology, Princess Alexandra Hospital, Brisbane, Queensland, Australia.

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Patient-Friendly Summary of the ACR Appropriateness Criteria Crohn Disease-Child.

J Am Coll Radiol 2022 Jun 13. Epub 2022 Jun 13.

interim Chief, Body Imaging Division, Director of Ultrasound, and Associate Director, Body Imagin Fellowship, Department of Radiology, Stanford University School of Medicine, Stanford, California. Electronic address:

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The role of PET imaging in inflammatory bowel diseases: state-of-the-art review.

Q J Nucl Med Mol Imaging 2022 Jun 16. Epub 2022 Jun 16.

Division of Nuclear Medicine and Oncological Imaging, University Hospital CHU of Liège, Liège, Belgium.

Inflammatory bowel diseases (IBD), i.e. Crohn disease and ulcerative colitis, are autoimmune processes of undetermined origin characterized by the chronic inflammation of the digestive tract. Read More

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Usefulness of ultrasonography for small intestinal evaluations in pediatric Crohn's disease.

Pediatr Int 2022 Jan;64(1):e15206

Department of Pediatrics, Osaka Medical and Pharmaceutical University, Takatsuki, Osaka, Japan.

Background: Small bowel capsule endoscopy (SBCE) for Crohn's disease is useful; however, its use has some limitations, such as invasiveness when endoscopic assistance is required in patients who cannot swallow the capsule, and the burden of interpretation on a physician. In contrast, intestinal ultrasonography (IUS) is a non-invasive modality for children. The purpose of this study is to evaluate the accuracy of IUS for pediatric patients with established Crohn's disease. Read More

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January 2022

A Systematic Review of Artificial Intelligence and Machine Learning Applications to Inflammatory Bowel Disease, with Practical Guidelines for Interpretation.

Inflamm Bowel Dis 2022 Jun 14. Epub 2022 Jun 14.

Pfizer Inc, New York, NY, USA.

Background: Inflammatory bowel disease (IBD) is a gastrointestinal chronic disease with an unpredictable disease course. Computational methods such as machine learning (ML) have the potential to stratify IBD patients for the provision of individualized care. The use of ML methods for IBD was surveyed, with an additional focus on how the field has changed over time. Read More

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[Position paper on reporting of intestinal ultrasound findings in patients with inflammatory bowel disease].

Z Gastroenterol 2022 Jun 7;60(6):978-990. Epub 2022 Jun 7.

Ambulanzzentrum Gastroenterologie, Klinik für Geriatrie, Klinikum Lüneburg, Lüneburg, Germany.

Background: Intestinal ultrasound is increasingly used for primary diagnosis, detection of complications and monitoring of patients with Crohn's disease and ulcerative colitis. Standardization of reporting is relevant to ensure quality of the methodology and to improve communication between different specialties. The current manuscript describes the features required for optimized reporting of intestinal ultrasound findings in inflammatory bowel disease (IBD). Read More

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Bone marrow adiposity in pediatric Crohn's disease.

Bone 2022 Jun 3;162:116453. Epub 2022 Jun 3.

Department of Pediatrics, Baylor College of Medicine, Houston, TX, United States of America.

Patients with Crohn's disease often have low bone mineral density and an increased risk of osteoporosis. Although decreased bone formation can be seen at diagnosis, the underlying pathophysiology of suboptimal bone accrual remains poorly understood. We sought to evaluate a novel mechanism affecting osteogenesis in patients with Crohn's disease. Read More

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[Advances in the management of inflammatory bowel diseases].

C Reenaers E Louis

Rev Med Liege 2022 May;77(5-6):323-329

Service de Gastroentérologie, CHU Liège, Belgique.

New therapeutic strategies and new molecules have been recently developed for the management of inflammatory bowel diseases. The treat-to-target strategy aims to define specific objectives based on the patient and the disease characteristics. A regular monitoring using biomarkers and imaging is required to assess the objectives' achievement. Read More

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Mucinous adenocarcinoma in perianal fistula in Crohn's disease: Case report and literature review.

Int J Surg Case Rep 2022 Jun 18;95:107211. Epub 2022 May 18.

Colorectal Surgery Unit, School of Medical Sciences, University of Campinas, Campinas, São Paulo, Brazil. Electronic address:

Introduction And Importance: Crohn's disease (CD) is a chronic bowel disease that, due to exacerbated inflammation, can lead to complications such as the development of perianal fistulas. The development of mucinous adenocarcinoma in perianal fistulas in patients with CD is rare and, consequently, few reports exist in the literature.

Case Presentation: We report the case of a 71-year-old man diagnosed 22 years ago with CD with perineal involvement, who came with complaints of intense perianal pain, a gluteal mass, and local bleeding. Read More

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Risankizumab as maintenance therapy for moderately to severely active Crohn's disease: results from the multicentre, randomised, double-blind, placebo-controlled, withdrawal phase 3 FORTIFY maintenance trial.

Lancet 2022 05;399(10340):2031-2046

AbbVie, Chicago, IL, USA.

Background: There is a great unmet need for new therapeutics with novel mechanisms of action for patients with Crohn's disease. The ADVANCE and MOTIVATE studies showed that intravenous risankizumab, a selective p19 anti-interleukin (IL)-23 antibody, was efficacious and well tolerated as induction therapy. Here, we report the efficacy and safety of subcutaneous risankizumab as maintenance therapy. Read More

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Risankizumab as induction therapy for Crohn's disease: results from the phase 3 ADVANCE and MOTIVATE induction trials.

Lancet 2022 05;399(10340):2015-2030

AbbVie, North Chicago, IL, USA.

Background: Risankizumab, an interleukin (IL)-23 p19 inhibitor, was evaluated for safety and efficacy as induction therapy in patients with moderately to severely active Crohn's disease.

Methods: ADVANCE and MOTIVATE were randomised, double-masked, placebo-controlled, phase 3 induction studies. Eligible patients aged 16-80 years with moderately to severely active Crohn's disease, previously showing intolerance or inadequate response to one or more approved biologics or conventional therapy (ADVANCE) or to biologics (MOTIVATE), were randomly assigned to receive a single dose of intravenous risankizumab (600 mg or 1200 mg) or placebo (2:2:1 in ADVANCE, 1:1:1 in MOTIVATE) at weeks 0, 4, and 8. Read More

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Intestinal fibrosis classification in patients with Crohn's disease using CT enterography-based deep learning: comparisons with radiomics and radiologists.

Eur Radiol 2022 May 26. Epub 2022 May 26.

Department of Radiology, The First Affiliated Hospital, Sun Yat-sen University, 58 Zhongshan II Road, Guangzhou, 510080, People's Republic of China.

Objectives: Accurate evaluation of bowel fibrosis in patients with Crohn's disease (CD) remains challenging. Computed tomography enterography (CTE)-based radiomics enables the assessment of bowel fibrosis; however, it has some deficiencies. We aimed to develop and validate a CTE-based deep learning model (DLM) for characterizing bowel fibrosis more efficiently. Read More

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Pediatric Inflammatory Bowel Disease: A Multicenter Study of Changing Trends in Argentina Over the Past 30 Years.

Pediatr Gastroenterol Hepatol Nutr 2022 May 9;25(3):218-227. Epub 2022 May 9.

Pediatric Gastroenterology, Hepatology and Liver Intestinal Transplantation Unit, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina.

Purpose: To analyze the characteristics of pediatric inflammatory bowel disease (IBD) over the past three decades in Argentina and determine if there are differences between the first two decades and the past decade.

Methods: We conducted a retrospective multicenter analytical study in children with IBD between 0 and 18 years of age diagnosed between 1987 and 2017 in three tertiary health centers in Argentina. The evaluation included clinical characterization, endoscopy, histology, and imaging data together with therapeutic strategies. Read More

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Inflammatory bowel disease biomarkers.

Med Res Rev 2022 May 23. Epub 2022 May 23.

Department of Chemistry, 788 Petit Science Center, Georgia State University, Atlanta, Georgia, USA.

Inflammatory bowel disease (IBD) is characterized as chronic inflammation in the gastrointestinal tract, which includes two main subtypes, Crohn's disease and ulcerative colitis. Endoscopy combined with biopsy is the most effective way to establish IBD diagnosis and disease management. Imaging techniques have also been developed to monitor IBD. Read More

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Tools for the Diagnosis and Management of Crohn's Disease.

Gastroenterol Clin North Am 2022 Jun 22;51(2):213-239. Epub 2022 Apr 22.

Division of Gastroenterology, Inflammatory Bowel Diseases Center, Washington University School of Medicine, 600 South Euclid Avenue, Campus Box 8124, Saint Louis, MO 63110, USA. Electronic address:

Numerous tools have emerged over recent decades to aid in the increasingly complex management of patients with Crohn's disease (CD) beyond endoscopy, including video capsule endoscopy, magnetic resonance enterography, computed tomography enterography, a variety of biomarkers, and even wearable biosensors and smartphone applications. These tools have allowed for a more sophisticated and less invasive complementary approach to the evaluation of disease activity and treatment response in patients with CD. This article details the characteristics, practical application, and limitations of these various modalities and discusses how updated guidelines are now incorporating many of them into a treat-to-target strategy. Read More

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Can visceral adipose tissue and skeletal muscle predict recurrence of newly diagnosed Crohn's disease in different treatments.

BMC Gastroenterol 2022 May 18;22(1):250. Epub 2022 May 18.

Department of Gastroenterology, The Third Xiangya Hospital of Central South University, 138 Tongzipo Road, Changsha, 410013, Hunan, China.

Background And Aims: It is crucial to manage the recurrence of Crohn's disease (CD). This study is aimed to explore whether visceral adipose tissue (VAT) and skeletal muscle (SM) are associated with the recurrence of CD upon different treatments.

Methods: All patients with a definite diagnosis of CD were retrospectively divided into three groups according to distinct treatment regimens: 5-amino salicylic acid group (Group A), steroids + azathioprine (Group B) and biologics (Group C). Read More

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Ultrasonographic scores for ileal Crohn's disease assessment: Better, worse or the same as contrast-enhanced ultrasound?

BMC Gastroenterol 2022 May 18;22(1):252. Epub 2022 May 18.

Gastroenterology Department, Hospital da Senhora da Oliveira, Guimarães, Portugal.

Background: Intestinal ultrasound (IUS) is an increasingly used non-invasive tool to evaluate Crohn's disease (CD) activity. Recently, two IUS scores that evaluate inflammatory activity have emerged: the Simple Ultrasound Activity Score for CD (SUS-CD) and the International Bowel Ultrasound Segmental Activity Score (IBUS-SAS). We aimed to compare the accuracy of SUS-CD, IBUS-SAS and contrast-enhanced ultrasound (CEUS) in predicting inflammatory activity in the terminal ileum in ileocolonoscopy in CD patients. Read More

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Establishing a rabbit model of perianal fistulizing Crohn's disease.

World J Gastroenterol 2022 Apr;28(15):1536-1547

Gastroenterology Center, The Affiliated Changzhou Second People's Hospital of Nanjing Medical University, Changzhou 213000, Jiangsu Province, China.

Background: Crohn's disease (CD) is a chronic nonspecific intestinal inflammatory disease. The aetiology and pathogenesis of CD are still unclear. Anal fistula is the main complication of CD and is a difficult problem to solve at present. Read More

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ACR Appropriateness Criteria® Crohn Disease-Child.

J Am Coll Radiol 2022 05;19(5S):S19-S36

Specialty Chair, Department of Medical Imaging, Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, Illinois.

Crohn disease is an inflammatory condition of the gastrointestinal tract with episodes of exacerbation and remission occurring in children, adolescents, and adults. Crohn disease diagnosis and treatment depend upon a combination of clinical, laboratory, endoscopic, histological, and imaging findings. Appropriate use of imaging provides critical information in the settings of diagnosis, assessment of acute symptoms, disease surveillance, and therapy monitoring. Read More

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Seminal vesicle fistula: a rare pathology in complicated Crohn's disease.

BMJ Case Rep 2022 May 6;15(5). Epub 2022 May 6.

General Surgery Department, Queen Elizabeth University Hospital, Glasgow, UK.

This case report describes a patient with complicated Crohn's disease who presented to a routine gastroenterology clinic complaining of increasing white discharge from a chronic perianal abscess. MRI of the perineum established the diagnosis of a seminal vesicle fistula connecting to the perianal skin. He was treated conservatively, with optimisation of his Crohn's disease medication regime. Read More

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Surgical Management of Small Bowel Crohn's Disease.

Front Surg 2022 15;9:759668. Epub 2022 Apr 15.

Department of Surgery, Faculty of Medicine, University of Kelaniya, Ragama, Sri Lanka.

Crohn's disease in the small bowel could present itself as an inflammatory stricture, a fibrotic stricture as penetrating disease or a combination of both. It is pertinent to differentiate the disease process as well as its extent to effectively manage the disease. Currently, a combination of medical and surgical therapies forms part of the treatment plan while the debate of which therapy is better continues. Read More

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Anti TNF treatment of complex perianal fistulas in children without luminal Crohn's disease: Is it an option?

J Pediatr Surg 2022 Apr 4. Epub 2022 Apr 4.

Division of Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, University of Toronto, Toronto, ON, Canada; SickKids Inflammatory Bowel Disease Center, The Hospital for Sick Children, University of Toronto, Toronto, ON, Canada.

Objectives: Complex perianal fistulas (CPFs) in children even in the absence of luminal symptoms prompt evaluation for Crohn's disease (CD). Reports of isolated CPF in children, however, are sparse. In perianal CD, antitumor necrosis factor α (anti TNF) therapy is recommended. Read More

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Pen Foreign Body Ingestion Mimicking Crohn's Disease in a Pediatric Patient.

R I Med J (2013) 2022 May 2;105(4):41-43. Epub 2022 May 2.

Department of Pediatrics, Hasbro Children's Hospital and the Warren Alpert Medical School of Brown University, Providence RI.

Foreign body ingestion is common in pediatrics, particularly in children with psychiatric illness. Foreign bodies present for extended periods of time can trigger a local inflammatory reaction causing weight loss, abdominal pain, and elevated inflammatory markers, mimicking inflammatory bowel disease (IBD). We report a case of intentional pen ingestion in a 13-year-old, whose clinical presentation with elevated inflammatory markers and terminal ileitis suggested on imaging was initially suspicious for Crohn's disease but was found on colonoscopy to be due to foreign body reaction from ingestion of a pen. Read More

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Correlation Among Body Composition Parameters and Long-Term Outcomes in Crohn's Disease After Anti-TNF Therapy.

Front Nutr 2022 1;9:765209. Epub 2022 Apr 1.

Gastroenterology and Endoscopy, Division of Metabolism and Biosystemic Science, Gastroenterology and Hematology/Oncology, Department of Medicine, Asahikawa Medical University, Asahikawa, Japan.

Background: The impact of the body composition on the pathophysiology and clinical course of Crohn's disease (CD) has not been fully elucidated.

Aims: To reveal the correlations among body composition and long-term outcomes in CD after anti-TNF therapy.

Methods: patients who received anti-TNF therapy as their first biologic treatment were enrolled. Read More

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Short-term anti-TNF therapy with surgical closure versus anti-TNF therapy in the treatment of perianal fistulas in Crohn's disease (PISA-II): a patient preference randomised trial.

Lancet Gastroenterol Hepatol 2022 Jul 12;7(7):617-626. Epub 2022 Apr 12.

Department of Surgery, Amsterdam University Medical Centre, University of Amsterdam, Amsterdam, Netherlands. Electronic address:

Background: Guidelines on Crohn's perianal fistulas recommend anti-tumour necrosis factor (TNF) treatment and suggest considering surgical closure for patients with surgically amenable disease. However, long-term outcomes following these two strategies have not been directly compared. The aim of this study was to assess radiological healing in patients who received short-term anti-TNF treatment and surgical closure compared with those who received anti-TNF treatment alone. Read More

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Artificial Intelligence Algorithm-Based Differential Diagnosis of Crohn's Disease and Ulcerative Colitis by CT Image.

Comput Math Methods Med 2022 4;2022:3871994. Epub 2022 Apr 4.

Department of Gastroenterology, The Third Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, Hunan 421001, China.

The aim of this study was to investigate the effect of low-dose CT enterography (CTE) based on modified guided image filtering (GIF) algorithm in the differential diagnosis of ulcerative colitis (UC) and Crohn's disease (CD). . One hundred and twenty patients with suspected diagnosis of IBD were studied. Read More

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Prevalence and predictors of non-alcoholic liver disease on MRI among patients with Crohn's disease.

BMC Gastroenterol 2022 Apr 12;22(1):183. Epub 2022 Apr 12.

Division of Gastroenterology and Hepatology; Shanghai Institute of Digestive Disease; NHC Key Laboratory of Digestive Diseases; Inflammatory Bowel Disease Center, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, 160 Pu Jian Road, Shanghai, 200127, China.

Background: It has been documented that Crohn's disease (CD) patients were prone to develop non-alcoholic liver fatty liver disease (NAFLD) with less metabolic factors. Our purpose is to investigate the prevalence, clinical characteristics and possible indicators for NAFLD in a cohort of Chinese patients with CD.

Methods: Established CD patients who underwent magnetic resonance enterography (MRE) at the gastroenterology unit of our hospital were consecutively enrolled between June 2018 and May 2020. Read More

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Basilar artery stroke in Crohn's disease treated with endovascular thromboembolectomy.

BMJ Case Rep 2022 Apr 11;15(4). Epub 2022 Apr 11.

Radiology and Neurological Surgery, University of Illinois College of Medicine at Peoria, Peoria, Illinois, USA

We describe a girl in middle childhood with newly diagnosed Crohn's disease, who presented with seizures and altered mental status. MRI showed an abnormal vascular signal at the basilar artery, but no evidence of acute ischaemia. Her weakness worsened over the next 8 hours to dense quadriplegia. Read More

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