42 results match your criteria Imaging in Classic Osteosarcoma

Metastatic osteosarcoma tumor thrombus in a Cavalier King Charles Spaniel presenting with dyspnea.

J Vet Cardiol 2022 Mar 23;41:209-215. Epub 2022 Mar 23.

Langford Vets, University of Bristol, Stock Lane, Lower Langford, North Somerset, BS40 5DU, United Kingdom; Highcroft Veterinary Referrals, 615 Wells Road, Whitchurch, Bristol, Avon, BS14 9BE, United Kingdom. Electronic address:

A six-year-seven-month-old female neutered Cavalier King Charles Spaniel was referred for the investigation of progressive dyspnea and hyphema in the right eye with secondary glaucoma. Previous medical history included a high-grade soft tissue spindle cell sarcoma removed from the cranial sternal region one year before. On presentation at the referral hospital, the dog was tachypneic and dyspneic. Read More

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Solid-variant aneurysmal bone cysts in the craniofacial skeleton: the role of genomic analysis.

Childs Nerv Syst 2022 Jan 31. Epub 2022 Jan 31.

Division of Neurosurgery, Connecticut Children's, Hartford, CT, USA.

Background: Solid variant aneurysmal bone cysts (SVABCs) are a rare but well-described subtype of ABCs. While classic ABCs are readily identified radiographically, SVABCs lack these characteristic radiographic features and thus have a wide differential diagnosis on presentation (including Ewing sarcoma, Langerhans cell histiocytosis, osteosarcoma, metastasis, and giant cell tumor). Genomic/molecular analyses are often necessary for the diagnosis of SVABCs, with USP6 rearrangements being a characteristic finding. Read More

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January 2022

Medical guidelines for Li-Fraumeni syndrome 2019, version 1.1.

Int J Clin Oncol 2021 Dec 11;26(12):2161-2178. Epub 2021 Oct 11.

Saga International Heavy Ion Cancer Radiation Therapy Center, Saga, Japan.

Li-Fraumeni syndrome (LFS) is a hereditary tumor that exhibits autosomal dominant inheritance. LFS develops in individuals with a pathogenic germline variant of the cancer-suppressor gene, TP53 (individuals with TP53 pathogenic variant). The number of individuals with TP53 pathogenic variant among the general population is said to be 1 in 500 to 20,000. Read More

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December 2021

Skeletal EWSR1-NFATC2 sarcoma previously diagnosed as Ewing-like adamantinoma: A case report and literature review emphasizing its unique radiological features.

Pathol Int 2021 Sep 30;71(9):614-620. Epub 2021 Jun 30.

Department of Diagnostic Pathology, National Hospital Organization Saitama Hospital, Saitama, Japan.

Ewing-like adamantinoma (EAD) is a rare bone tumor. It remains unclear whether EAD belongs to adamantinoma, Ewing sarcoma (ES), or an independent category. Herein, we present a case of femoral sarcoma previously diagnosed as EAD in a 26-year-old woman. Read More

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September 2021

Calcified Adrenal Metastasis of High-Grade Osteosarcoma on FDG PET/CT.

Clin Nucl Med 2021 Mar;46(3):e176-e178

From the Departments of Nuclear Medicine.

Abstract: Classic type of high-grade osteosarcoma is the most common type of skeletal malignancy in children and adolescents. Metastasis of osteosarcoma frequently occurs in the lung. Adrenal metastasis of osteosarcoma is extremely rare, with only few reported case in the literature. Read More

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Bone Tumors Occurring in the Soft Tissues: A Review of the Clinical, Imaging, and Histopathologic Findings.

Curr Probl Diagn Radiol 2021 May-Jun;50(3):419-429. Epub 2020 Jun 26.

Temple University Hospital. Philadelphia, PA.

Although rare in everyday practice, malignancies that classically arise from bone or cartilage have been reported to arise de novo in various soft tissues in the body, resulting in a diagnostic challenge for the clinician, radiologist, and pathologist. Differential diagnoses of bone tumors often depend on anatomic location of the lesion. For example, the classic location of osteosarcoma is in the metaphysis of long bones about the knee. Read More

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October 2021

[The importance of radiology in bone sarcoma diagnostics : Initial and advanced diagnostics].

Volker Vieth

Orthopade 2019 Sep;48(9):727-734

Klinik für Radiologie, Klinikum Ibbenbüren, Große Straße 41, 49477, Ibbenbüren, Deutschland.

Background: Reliable diagnostic assessment of malignant bone lesions remains a challenge in all the medical disciplines involved. The high incidence of benign (mainly pediatric) bone lesions needs to be distinguished from the rare malignant counterparts. If clinical presentation and patient history are unable to exclude a malignant tumour, adequate imaging of the affected region is necessary. Read More

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September 2019

Conventional chondrosarcoma with focal clear cell change: a clinicopathological and molecular analysis.

Histopathology 2019 Dec 13;75(6):843-852. Epub 2019 Sep 13.

Department of Pathology, Leiden University Medical Centre, Leiden, The Netherlands.

Aims: Clear cell chondrosarcomas are known to occasionally contain areas of low-grade conventional chondrosarcoma; however, the opposite phenomenon has not yet been described. We identified five cases of conventional chondrosarcoma alongside clear cell chondrosarcoma. Here, we report on their clinicopathological and molecular characteristics, and investigate whether these hybrid lesions should be considered to be a collision tumour, conventional chondrosarcoma with clear cell change, or clear cell chondrosarcoma with extensive areas of conventional chondrosarcoma, as this has clinical implications. Read More

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December 2019

Diagnostic evaluation and treatment of primary breast osteosarcoma: A case report.

Breast J 2019 07 11;25(4):709-711. Epub 2019 May 11.

Department of Radiology, University of Texas Southwestern Medical Center, Dallas, Texas.

Primary breast osteosarcoma (PBO) is a rare tumor of the breast, with only case reports and small case series published in the literature. Classic imaging findings of sunburst calcifications, a rim of intermediate density, and intense uptake on bone scintigraphy can help make the correct diagnosis preoperatively, allowing for appropriate surgical and chemotherapeutic management. We present the imaging evaluation, treatment course, and follow-up of a case of PBO diagnosed in a 67-year-old patient. Read More

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A Time-lapse, Label-free, Quantitative Phase Imaging Study of Dormant and Active Human Cancer Cells.

J Vis Exp 2018 02 16(132). Epub 2018 Feb 16.

Vascular Biology Program, Boston Children's Hospital; Department of Surgery, Harvard Medical School and Boston Children's Hospital;

The acquisition of the angiogenic phenotype is an essential component of the escape from tumor dormancy. Although several classic in vitro assays (e.g. Read More

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February 2018

Malignant tumours of the foot and ankle.

EFORT Open Rev 2017 May 11;2(5):261-271. Epub 2017 May 11.

Laboratoire d'anatomie et cytologie pathologiques, Institut Universitaire du Cancer de Toulouse- Oncopole, 1 avenue Irène Joliot-Curie. 31059 Toulouse Cedex 9, France.

Most of tumours of the foot are tumour-like (synovial cyst, foreign body reactions and epidermal inclusion cyst) or benign conditions (tenosynovial giant cells tumours, planta fibromatosis). Malignant tumours of the soft-tissue and skeleton are very rare in the foot and their diagnosis is often delayed with referral to specialised teams after initial inappropriate procedures or unplanned excisions. The adverse effect of these misdiagnosed tumours is the increasing rate of amputation or local recurrences in the involved patients. Read More

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Therapy-Induced Neural Differentiation in Ewing's Sarcoma: A Case Report and Review of the Literature.

Turk Patoloji Derg 2019 ;35(2):139-143

Department of Pathology, Cukurova University Faculty of Medicine, ADANA, TURKEY.

Ewing's sarcoma (ES) is a small round cell tumor of adolescents or young adults that usually arises in the deep soft tissues of the extremities. The tumor cells have uniform round nuclei, fine powdery chromatin and indistinct nucleoli. CD99 (O13) is a product of the MIC 2 gene that is highly sensitive to ES but not specific. Read More

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September 2019

Primary intracranial Ewing's sarcoma with unusual features.

Int J Clin Exp Pathol 2015 1;8(1):260-74. Epub 2015 Jan 1.

Department of Pathology, University of Oklahoma Health Sciences Center Oklahoma City, OK 73104, USA ; Department of Pathology, Oklahoma City Veterans Administration Medical Center Oklahoma City, OK 73104, USA.

Pediatric primary "small round blue cell" tumors in the CNS represent several entities, some more common than others. Ewing sarcoma/peripheral primitive neuroectodermal tumor (ES/pPNET) is rare and must be distinguished from other tumors such as medulloblastoma [1, 2], atypical rhabdoid/teratoid tumor, ependymomal tumors, metastatic sarcomas, hematologic malignancies, and other mimics. Although therapy for ES/pPNET is effective, it brings severe side effects, including cardiac toxicity, making correct recognition important [3]. Read More

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December 2015

Sclerotic multiple myeloma with an unusual sunburst periosteal reaction occurring in the sternum.

Skeletal Radiol 2015 May 29;44(5):749-54. Epub 2014 Oct 29.

Department of Radiology, Third Hospital of Hebei Medical University, Hebei Province Biomechanical Key Laboratory of Orthopedics, 139 Ziqiang Road, Shijiazhuang City, 050051, Hebei Province, China,

Multiple myeloma is a disseminated neoplastic monoclonal gammopathy that usually affects the skull, clavicle, rib, pelvis, spinal column, and proximal portions of the humerus and femur. The initial manifestation of multiple myeloma in the sternum is rare. The classic radiological presentations of multiple myeloma are multiple "punched-out" areas of bone destruction, expansile lytic lesions, and generalized osteoporosis. Read More

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Cavernous hemangioma of the frontal bone: a case report.

J Med Case Rep 2014 Apr 9;8:121. Epub 2014 Apr 9.

Department of Neurosurgery, San Salvatore City Hospital, via Vetoio, Coppito, L'Aquila 67100, Italy.

Introduction: Cavernous hemangiomas are rare benign bone tumors and those at the level of the cranial bones are even rarer.

Case Presentation: A 50-year-old woman of Italian ethnicity presented with a frontal mass. A computed tomography scan showed an osteolytic lesion and a magnetic resonance imaging scan revealed a hypointense lesion on the T1-weighted image and a hyperintense lesion on the T2-weighted image. Read More

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Osteosarcoma: review of the various types with emphasis on recent advancements in imaging.

Semin Musculoskelet Radiol 2013 Apr 14;17(2):123-36. Epub 2013 May 14.

Department of Radiology and Medical Imaging, University of Virginia, Charlottesville, VA 22908, USA.

Osteosarcoma is the classic malignant osteoid-forming bone tumor. The typical clinical presentation, histology, imaging findings, treatment, and prognosis for each subtype of osteosarcoma is provided. Particular emphasis is placed on more current magnetic resonance imaging and nuclear medicine imaging techniques that may soon improve the ability to determine the most appropriate therapy and ultimately improve patient survival. Read More

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Primary Ewing's sarcoma/primitive neuroectodermal tumor (ES/PNET) of the penis: a report of an extraordinarily unusual site and a literature review of extraskeletal Ewing's sarcoma.

Int J Surg Pathol 2013 Feb 25;21(1):63-7. Epub 2012 Jul 25.

St Luke's-Roosevelt Hospital Center, New York, NY 10019, USA.

Ewing's sarcomas/primitive neuroectodermal tumors (ES/PNETs) arise from a multipotent progenitor cell and are considered to be of neuroectodermal derivation. Most tumors commonly arise in the skeletal system, which are the classic ES/PNET and occasionally occur in the soft tissue of extraskeletal sites, which are named extraskeletal Ewing's sarcomas (EES/PNET). This study reports a case of a 28-year-old man with primary EES/PNET of the penis. Read More

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February 2013

Localized extraosseous Ewing's sarcoma of the chest wall resected by video-assisted thoracoscopic surgery.

Gen Thorac Cardiovasc Surg 2010 Dec 18;58(12):647-50. Epub 2010 Dec 18.

Department of Surgery, Kagawa Prefectural Central Hospital, 5-4-16 Ban-cho, Takamatsu, Kagawa, 760-8557, Japan.

Extraosseous Ewing's sarcoma (ES) is a small round cell tumor arising in soft tissue that was undifferentiated histologically from classic ES of bone. It frequently affects children and adolescents, with an unfavorable prognosis. Herein, we report a case of localized extraosseous ES of the chest wall resected by video-assisted thoracoscopic surgery (VATS). Read More

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December 2010

Small cell osteosarcoma: cytopathologic characteristics and differential diagnosis.

Am J Clin Pathol 2010 May;133(5):756-61

Department of Pathology, The Johns Hopkins Hospital, 600 N Wolfe St, Path 406, Baltimore, MD 21287, USA.

Small cell osteosarcoma may present a challenging primary diagnosis on cytologic assessment owing to its rarity and its morphologic similarity to other small round blue cell tumors. Five cases of small cell osteosarcoma from our cytopathology archives were identified and reviewed and cytologic features elaborated. Three cases were fine-needle aspirations from bony lesions in the classic location for osteosarcoma (2 distal femur and 1 proximal tibia), and 2 aspirations were from metastases. Read More

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Osteosarcoma of the lumbar vertebra: case report and a review of the literature: rare localization with long survival.

Arch Orthop Trauma Surg 2009 Dec 14;129(12):1701-5. Epub 2009 May 14.

Department of Orthopaedic Surgery and Traumatology, Trakya University, 22030, Edirne, Turkey.

Classic osteosarcoma (OS) is a highly malignant sarcoma with the production of osteoid matrix. The most common sites of origin are the metaphyseal regions of the distal femur, proximal tibia, and proximal humerus, although the tumor can develop in any bone. Flat bone involvement is very rare (8%). Read More

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December 2009

Dedifferentiated chromophobe renal cell carcinoma with massive osteosarcoma-like divergent differentiation: a singular entity in the spectrum of retroperitoneal calcifying tumors.

Int J Surg Pathol 2010 Oct 18;18(5):419-23. Epub 2008 Dec 18.

Department of Clinical Sciences, University of Parma, Parma, Italy.

Sarcomatoid change in renal cell carcinoma is the result of the dedifferentiation of the "parent" tumor into a high-grade malignancy characterized by sarcoma-like features and associated with an accelerated clinical course and poorer prognosis. Any of the renal cell carcinoma subtypes can undergo sarcomatoid dedifferentiation, with the chromophobe variant being the most prone. The present report describes the case of a woman affected by a classic chromophobe renal cell carcinoma that developed dedifferentiation accompanied by a very rare osteosarcoma-like divergent differentiation, which constituted about 90% of the entire retroperitoneal mass. Read More

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October 2010

Malignant tumours of the heart: a review of tumour type, diagnosis and therapy.

Clin Oncol (R Coll Radiol) 2007 Dec 10;19(10):748-56. Epub 2007 Aug 10.

Department of Surgery, University Hospitals of Cleveland, Case Western Reserve University, School of Medicine, Cleveland, OH 44106, USA.

Primary cardiac neoplasms are rare and occur less commonly than metastatic disease of the heart. In this overview, current published studies concerning malignant neoplasms of the heart are reviewed, together with some insights into their aetiology, diagnosis and management. We searched medline using the subject 'cardiac neoplasms'. Read More

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December 2007

Aggressive osteogenic desmoplastic melanoma: a case report.

J Cutan Pathol 2007 May;34(5):423-6

Department of Dermatopathology, Mount Sinai Medical Center, New York, NY, USA.

A case of an osteogenic desmoplastic melanoma occurring on the sole of the foot of a 60-year-old African American man is described. The tumor measured 4.8 cm in greatest dimension, invaded to a thickness of 2. Read More

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Osteosarcoma (osteogenic sarcoma).

Piero Picci

Orphanet J Rare Dis 2007 Jan 23;2. Epub 2007 Jan 23.

Rizzoli Orthopaedic Institute, Scientific Institution for Research Hospitalization and Health Care, Bologna, Italy.

Osteosarcoma is a primary malignant tumour of the skeleton characterised by the direct formation of immature bone or osteoid tissue by the tumour cells. The classic osteosarcoma is a rare (0.2% of all malignant tumours) highly malignant tumour, with an estimated incidence of 3 cases/million population/year. Read More

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January 2007

Radiology quiz case 2. Classic osteosarcoma of the temporal bone.

Arch Otolaryngol Head Neck Surg 2005 Oct;131(10):922, 926

Diyarbakir Military Hospital, Diyarbakir, Turkey.

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October 2005

Ewing's sarcoma of the cavernous sinus: case report.

Neurosurgery 2005 Jun;56(6):E1375; discussion E1375

Department of Neurosurgery, University of Minnesota, Minneapolis, Minnesota 55455, USA.

Objective And Importance: The Ewing's sarcoma (ES) family of tumors is a relatively rare entity, presenting most commonly in children. While the most common sites for this group of tumors are the trunk and the extremities, this case is unique in that we describe a long-term follow-up with an ES presenting in the cavernous sinus.

Clinical Presentation: We report the case of a 13-year-old girl presenting with the symptoms of classic orbital apex syndrome. Read More

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Radiographic features of Ewing's sarcoma of the bones of the hands and feet.

Skeletal Radiol 2001 Mar;30(3):121-6

Department of Radiology, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA.

The radiographic features of Ewing's sarcoma of the bones of the hands and feet are reviewed utilizing cases obtained from the Mayo Clinic patient files and the consultation files of Drs. D.C. Read More

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Juxtacortical osteosarcoma. A distinct malignant bone neoplasm.

Adv Clin Path 2000 Jul;4(3):127-31

Anatomy Department, Faculty of Health and Caring Professions, Technological Educational Institution, Athens. Greece.

The purpose of this report is the study of a malignant bone tumor of similar histological picture with conventional (intramedullary) osteosarcoma. Contributing factors in the study of juxtacortical osteosarcoma are the clinical, X-ray and histologic pictures. A case of parosteal osteosarcoma in a 28-year-old male is reported. Read More

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[Primary chemotherapy with the Rosen T10 protocol before conservative surgery in limb primitive osteosarcomas: results about 56 cases].

Bull Cancer 2000 Feb;87(2):183-8

Institut Salah Azaïz, Tunis, Tunisie.

We report the results of a prospective Tunisian study using primary chemotherapy followed by conservative surgery in primitive limb osteosarcoma. From January 1988 to January 1998, 56 patients affected by limb osteosarcoma entered in a prospective study of neoadjuvant chemotherapy with the T10 protocol before surgery with a conservative intent. Initial work-up include: clinical exam with tumor measurements, chest and limb X-rays, limb CT-scan or MRI, chest CT-scan, bone scintigraphy and hematological and renal biological exams. Read More

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February 2000

Malignant tumors of the osteogenic matrix.

Eur J Radiol 1998 May;27 Suppl 1:S98-109

Institute of Radiology of the University of Modena, Policlinico, Italy.

This article focuses on major clinical and imaging features that are of practical interest in the diagnosis and management of osteosarcoma, a malignant tumor arising from the osteogenic matrix. The current histologic classification of this tumor is also reported. Different types of osteosarcoma are described, each of them with a definite clinical and radiographic pattern. Read More

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