1,643 results match your criteria Imaging in Chordoma


A Cystic Clival Chordoma with CT and MRI Unconventional Appearances.

Indian J Radiol Imaging 2022 Mar 28;32(1):127-131. Epub 2022 Feb 28.

UOC Radiodiagnostica e Neuroradiologia, Dipartimento di Diagnostica per Immagini, Radioterapia, Oncologia ed Ematologia, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.

We present the first case of clival cystic chordoma with extradural location, transdural transgression, and moderate bone involvement in a 10-year-old girl. Chordoma showed unconventional appearances on computed tomography (CT) and magnetic resonance imaging (MRI), due to cystic components, extradural space location with extensive intradural extension, moderate superficial bone involvement. Surgery confirmed the extradural location and histopathological examination revealed cystic chordoma. Read More

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Surgical Strategies and Outcomes for Intracranial Chondromas: A Retrospective Study of 17 Cases and Systematic Review.

Front Oncol 2022 26;12:865865. Epub 2022 May 26.

Department of Neurosurgery, Tangdu Hospital, Air Force Medical University, Xi'an, China.

Objective: To improve the diagnosis and treatment of intracranial chondromas (ICDs) by discussing the clinical manifestations and imaging characteristics of ICDs, as well as surgical methods and treatment strategies.

Methods: We retrospectively analyzed 17 patients diagnosed with ICDs who underwent microsurgery or endoscopic transsphenoidal surgery at the Tangdu Hospital of Air Force Military Medical University and the Mianyang Central Hospital from January 2010 to November 2021. Clinical manifestations, imaging examinations, surgical treatments, and prognosis of these patients were analyzed. Read More

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Radiographic appearance of a caudal vertebral chordoma in a domestic ferret (Mustela putorius furo).

Vet Radiol Ultrasound 2022 Jun 12. Epub 2022 Jun 12.

Department of Medical Imaging, Veterinary Medical Center at the Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, S7N 3Z1, Canada.

A 7-year-old spayed female ferret was presented to the Veterinary Teaching Hospital at the Western College of Veterinary Medicine for a slow-growing mass involving the base of the tail. Radiographs revealed a large, irregularly marginated mineralized mass centered on the fifth to seventh caudal vertebrae with osteolysis of the affected caudal vertebrae. A partial caudectomy was performed, and histopathology was consistent with a chordoma. Read More

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Preliminary study of monoexponential, biexponential, and stretched-exponential models of diffusion-weighted MRI and diffusion kurtosis imaging on differential diagnosis of spinal metastases and chordoma.

Eur Spine J 2022 Jun 1. Epub 2022 Jun 1.

Department of Radiology, Peking University Third Hospital, 49 North Garden Road, Haidian District, Beijing, 100191, People's Republic of China.

Purpose: Quantitative comparison of diffusion parameters from various models of diffusion-weighted (DWI) and diffusion kurtosis (DKI) imaging for distinguishing spinal metastases and chordomas.

Methods: DWI and DKI examinations were performed in 31 and 13 cases of spinal metastases and chordomas, respectively. DWI derived apparent diffusion coefficient (ADC), true diffusion coefficient (D), pseudo diffusion coefficient (D*), perfusion fraction (f), water molecular distributed diffusion coefficient (DDC), and intravoxel water diffusion heterogeneity (α). Read More

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Unilateral Compressive Optic Neuropathy As the Presenting Manifestation of Clival Chordoma: A Case Report.

Cureus 2022 Apr 24;14(4):e24440. Epub 2022 Apr 24.

Ophthalmology, Houston Methodist Hospital, Houston, USA.

The optic nerve(s) may be compressed by a number of intracranial and intraorbital masses. Compression may be isolated to the optic nerve or may involve other intracranial or intraorbital structures with variable presentation. A 26-year-old man presented with complaints of progressive painless visual loss in the right eye for eight months. Read More

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Radiological Diagnosis of a Rare Prepontine Lesion: Ecchordosis Physaliphora.

Cureus 2022 Apr 21;14(4):e24335. Epub 2022 Apr 21.

Radiology, Tata Main Hospital, Jamshedpur, IND.

Ecchordosis physaliphora (EP) is a notochordal remnant tissue rarely encountered during routine clinical practice. These lesions usually do not produce any significant symptoms as they are slow-growing and mostly small in size. Symptoms are due to mass effects on adjacent structures when they are large or extra-tumoral hemorrhage. Read More

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An Unusual Chordoma of the Odontoid Process: A Case Report and Literature Review.

J Am Acad Orthop Surg Glob Res Rev 2022 May 1;6(5). Epub 2022 May 1.

From the Department of Orthopaedics, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.

The aim of this study is to present a rare case of chordoma in the odontoid process in which the tumor involved the odontoid process and compressed the spinal cord at the craniocervical junction. We report on the effectiveness and successful outcome of anterior microscopic tumor resection combined with posterior occipitocervical fixation and review the current standard treatment. A 39-year-old man presented with sudden dyspnea and quadriparesis caused by an unknown tumor compression at C2. Read More

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Ecchordosis Physaliphora - Classical MRI Image.

Neurol India 2022 Mar-Apr;70(2):834-835

Department of Radiodiagnosis, Sree Balaji Medical College and Hospital; Consultant Radiologist, IVR Scans, Chennai, Tamil Nadu, India.

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Clinical Grading System, Surgical Outcomes and Prognostic Analysis of Cranial Base Chordomas.

J Korean Neurosurg Soc 2022 May 25;65(3):469-478. Epub 2022 Apr 25.

School of Medicine, Nankai University, Tianjin, China.

Objective: Cranial base chordomas are rare, but their treatment is challenging. Tumor recurrence is still common despite improvements in microsurgical techniques and postoperative radiotherapy. We retrospectively analyzed the course of treatment, overall survival, and recurrence/progression of chordomas over the past 10 years. Read More

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High dose image-guided, intensity modulated radiation therapy (IG-IMRT) for chordomas of the sacrum, mobile spine and skull base: preliminary outcomes.

J Neurooncol 2022 May 22;158(1):23-31. Epub 2022 Apr 22.

Department of Spine Surgery, Instituto do Câncer do Estado de São Paulo, Hospital das Clínicas da Faculdade de Medicina da USP, São Paulo, Brazil.

Purpose: To report preliminary outcomes of high dose image-guided intensity modulated radiotherapy (IG-IMRT) in the treatment of chordomas of the sacrum, mobile spine and skull base.

Methods: Retrospective analysis of chordoma patients treated with surgery and/or radiotherapy (RT) in a single tertiary cancer center. Initial treatment was categorized as (A) Adjuvant or definitive high-dose RT (78 Gy/39fx or 24 Gy/1fx) vs (B) surgery-only or low dose RT. Read More

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Ectopic Recurrence of Skull Base Chordoma after Proton Therapy.

Curr Oncol 2022 03 28;29(4):2364-2375. Epub 2022 Mar 28.

Department of Neurosurgery, Maastricht University Medical Center, 6229 HX Maastricht, The Netherlands.

Background: Chordoma are rare tumors of the axial skeleton. The treatment gold standard is surgery, followed by particle radiotherapy. Total resection is usually not achievable in skull base chordoma (SBC) and high recurrence rates are reported. Read More

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An unusual presentation of chordoma as a pyloric ring submucosal tumor: The first case report of a primary gastrointestinal lesion in humans.

Int J Surg Case Rep 2022 May 6;94:107032. Epub 2022 Apr 6.

Department of Pathology, Undergraduate School of Medicine, Shiga University of Medical Science, Otsu, Shiga 520-2192, Japan; Pathology Division, National Cancer Center Hospital, Tokyo 104-0045, Japan.

Introduction And Importance: Chordomas are rare malignant bone neoplasms that are presumed to arise from chordal remnants in the fetal stage and typically occur along the axial skeleton. The extra-skeletal chordomas reported to date include soft tissue of the extremities and nasopharynx. Chordoma arising from the gastrointestinal wall has not been previously described. Read More

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Chondrosarcoma and Chordoma of the Skull Base and Spine: Implication of Tumor Location on Patient Survival.

World Neurosurg 2022 Jun 24;162:e635-e639. Epub 2022 Mar 24.

Department of Neurosurgery, Oklahoma University Health Sciences Center, Oklahoma City, Oklahoma, USA. Electronic address:

Background: Chondrosarcoma and chordoma are often grouped together because of their similar anatomic locations, clinical presentations, histopathological and radiological findings, and growth patterns. In the present study, we investigated the clinical and prognostic differences of chondrosarcomas and chordomas of the skull base and spine.

Methods: We accessed the Surveillance, Epidemiology, and End Results database to search for patients from 2000 to 2018 with chondrosarcomas and chordomas of the skull base and spine for inclusion in the present study. Read More

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MRI enhancement patterns in 28 cases of clival chordomas.

J Clin Neurosci 2022 May 9;99:117-122. Epub 2022 Mar 9.

Mayo Clinic, Department of Radiology. Rochester, MN, USA.

Clival chordomas are classically thought of as locally aggressive tumors of the skull base and differentiate themselves from their benign counterparts by demonstrating moderate to marked contrast enhancement, reported as 95-100% in prior studies. The purpose of this review was to evaluate the imaging characteristics of lesions from a single institution classified as clival chordomas with an emphasis of highlighting lesions that do not follow the prevalent current description for chordoma. We searched our institutional databases for all patients with pathologically proven clival chordomas from 1997 to 2017 who had pre-operative imaging available. Read More

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Isolated Hypoglossal Nerve Palsy as an Early Symptom of a Granular Cell Tumor.

Int J Environ Res Public Health 2022 02 25;19(5). Epub 2022 Feb 25.

Department of Oral and Maxillofacial Surgery, Ruhr University Knappschaftskrankenhaus Bochum, 44892 Bochum, Germany.

Background: Hypoglossal nerve palsy (HNP) is rather common as a neurological disease. However, as an isolated nerve palsy it is an exceedingly rare phenomenon and points at local pathologies along the peripheral course of the nerve. In this communication we report a granular cell tumor (GCT) arising in the submandibular segment of the hypoglossal nerve. Read More

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February 2022

The mini-combined transpetrosal approach: an anatomical study and comparison with the combined transpetrosal approach.

Acta Neurochir (Wien) 2022 04 1;164(4):1079-1093. Epub 2022 Mar 1.

Department of Neurosurgery, Lariboisière Hospital, Assistance Publique - Hôpitaux de Paris, Paris, France.

Background: The combined transpetrosal approach (CTPA) is a versatile technique suitable for challenging skull base pathologies. Despite the advantages provided by a wide surgical exposure, the soft tissue trauma, complex and time-consuming bony work, and cosmetic issues make it far from patient expectations. In this study, the authors describe a less invasive modification of the CTPA, the mini-combined transpetrosal approach (mini-CTPA), and perform a quantitative comparison between these two approaches. Read More

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Multimodal Intraoperative Image-Driven Surgery for Skull Base Chordomas and Chondrosarcomas.

Cancers (Basel) 2022 Feb 15;14(4). Epub 2022 Feb 15.

Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.

Given the difficulty and importance of achieving maximal resection in chordomas and chondrosarcomas, all available tools offered by modern neurosurgery are to be deployed for planning and resection of these complex lesions. As demonstrated by the review of our series of skull base chordoma and chondrosarcoma resections in the Advanced Multimodality Image-Guided Operating (AMIGO) suite, as well as by the recently published literature, we describe the use of advanced multimodality intraoperative imaging and neuronavigation as pivotal to successful radical resection of these skull base lesions while preventing and managing eventual complications. Read More

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February 2022

Coexpression of HHLA2 and PD-L1 on Tumor Cells Independently Predicts the Survival of Spinal Chordoma Patients.

Front Immunol 2021 25;12:797407. Epub 2022 Jan 25.

Department of Spine Surgery, The First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, China.

Background: Immunotherapy only achieves efficacy in some cancer patients, and less is known about other immune checkpoint molecules in chordoma. Here, we aimed to determine the expression of PD-L1, HHLA2, B7H3, IDO-1 and Galectin-9 in spinal chordoma and evaluated their association with tumor infiltrating lymphocytes (TILs), clinicopathological characteristics and survival of patients.

Methods: Using multiplexed quantitative immunofluorescence (QIF), we simultaneously measured the levels of five different immune checkpoint molecules and major TIL subsets in 92 human spinal chordoma samples. Read More

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February 2022

Spinal Dysraphisms: A New Anatomical-Clinicoradiological Classification.

Indian J Radiol Imaging 2021 Oct 11;31(4):809-829. Epub 2022 Jan 11.

Department of Radiodiagnosis, Government Stanley Medical College, Chennai, Tamil Nadu, India.

 Spinal dysraphisms refer to the congenital abnormalities of the spine and spinal cord due to aberrations in the processes of gastrulation, primary neurulation, and secondary neurulation. Embryology of many complex spinal dysraphisms are yet poorly understood and there is no agreeable anatomical-clinicoradiological classification with inclusion of recently documented and complex spinal dysraphisms.  The main objective of this study was to review the imaging features of spinal dysraphisms with a better understanding of embryological abnormalities and propose a new classification inclusive of all complex and unusual dysraphisms based on anatomical and clinicoradiological correlation. Read More

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October 2021

[Minimally invasive and O-arm assisted en bloc spinal tumor resections].

Ideggyogy Sz 2022 Jan;75(1-02):65-72

Pécsi Tudományegyetem, Idegsebészeti Klinika, Pécs.

Background And Purpose: The en bloc resection of spinal tumors is required in primary spine tumors and in selected cases of secondary spine tumors, where the primary disease is under control and long survival time is expected. Three cases are presented, applying O-arm assisted navigation or minimally invasive anterior approaches for en bloc tumor removal.

Methods: O-arm navigation assisted osteotomies were carried out to remove a Th. Read More

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January 2022

Poorly Differentiated Chordoma of the Clivus With Loss of SMARCB1 Expression in a Pediatric Patient: A Case Report.

J Pediatr Hematol Oncol 2022 Jan 28. Epub 2022 Jan 28.

Department of Pediatrics, Gifu University Graduate School of Medicine Department of Pathology, Gifu University Hospital, Gifu Depertment of Hematology and Oncology, Children's Cancer Center Depertment of Neurosurgery, Childhood Cancer Medical Center, Hyogo Prefectural Kobe Children's Hospital Department of Radiation Oncology, Hyogo Ion Beam Medical Center Kobe Proton Center, Kobe, Japan.

Poorly differentiated chordoma (PDC) is a rare, aggressive subtype of chordoma. A two-year-old girl presented with cervical pain, limb paralysis and respiratory failure. Magnetic resonance imaging and positron emission tomography-computed tomography revealed a tumor compressing the pons at the clivus and osteoblastic metastatic lesions of the left upper arm and right iliac bone. Read More

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January 2022

Intraoperative Magnetic Resonance Imaging Assisted Endoscopic Endonasal Resection of Clival Chordomas.

Front Oncol 2021 10;11:733088. Epub 2022 Jan 10.

Department of Neurosurgery, Gazi University Faculty of Medicine, Ankara, Turkey.

Background: Cranial base chordomas are typically indolent and usually appear as encapsulated tumors. They slowly grow by infiltrating the bone, along with the lines of least resistance. Due to its relationship with important neurovascular structures, skull base chordoma surgery is challenging. Read More

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January 2022

Oral extrusion of a vertebral body replacement device after chordoma tumor growth and radiation: case report and review.

BMC Surg 2022 Jan 22;22(1):22. Epub 2022 Jan 22.

Department of Neurosurgery, "Puerta de Hierro" University Hospital, C/. Joaquin Rodrigo 2, 28222, Majadahonda, Madrid, Spain.

Background: Screw migration following anterior cervical discectomy and fusion is a very rare complication and it is often related to device failure. Even more exceptional is the extrusion of an intervertebral graft.

Case Presentation: We report the second case of migration and extrusion through the oral cavity of a cervical vertebral body replacement device (expandable cylinder) in a patient that had undergone cervical corpectomy due to a vertebral chordoma. Read More

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January 2022

Metastatic chordoma with pancreatic disease and response to imatinib.

BMJ Case Rep 2022 Jan 19;15(1). Epub 2022 Jan 19.

Department of Radiology, NHS Greater Glasgow and Clyde, Glasgow, UK.

A 45-year-old woman presented with a left-sided neck swelling following treatment a year prior for cervical spine chordoma. She had initially been managed surgically with a cervical vertebrectomy and a course of proton beam therapy. Although there had been a degree of residual tissue, her disease remained stable radiologically and clinically. Read More

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January 2022

Long-term outcome of adjunctive Gamma Knife radiosurgery in skull-base chordomas and chondrosarcomas: An Indian experience.

J Clin Neurosci 2022 Feb 11;96:90-100. Epub 2022 Jan 11.

Department of Pathology, P D Hinduja National Hospital, Mumbai 400016, India.

Skull-base chordomas (CD) and chondrosarcomas (CS) are locally-invasive tumors, have similar clinical presentations, while differing in their nature of growth and outcomes. In this study, we compare the long-term outcomes of Gamma Knife Radiosurgery (GKRS) as an adjunctive treatment modality for residual skull-base CD and CS. A retrospective analysis of clinico-radiological, pathological, radiotherapeutic and outcome data was carried out in patients who underwent adjunctive GKRS for residual skull-base CD and CS at P D Hinduja Hospital, Mumbai, between 1997 and 2020. Read More

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February 2022

Endoscopic Endonasal Pituitary Hemi-Rotation Approach to the Upper Clivus: Anatomical Study and Clinical Report.

Turk Neurosurg 2022 ;32(2):315-322

University of Insubria, Department of Biotechnology and Life Sciences, Division of Neurosurgery; Ospedale di Circolo e Fondazione Macchi, Varese, Italy.

Aim: To report on the endoscopic endonasal pituitary hemi-rotation approach (EPHRA) in a preclinical setting and in a preliminary clinical experience.

Material And Methods: EPHRA was performed in five fresh-frozen head and neck specimens (a total of 10 sides) and in a selected case of a right-sided dorsum sellae chordoma.

Results: The approach described allowed exposure of the lateral part of the upper clivus in all the specimens and in the case reported. Read More

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Imaging features of cartilaginous tumors of the head and neck.

J Clin Imaging Sci 2021 4;11:66. Epub 2021 Dec 4.

Department of Radiology, Mayo Clinic Arizona, Phoenix, Arizona, United States.

There is a wide spectrum of head and neck cartilaginous lesions which include both neoplastic and nonneoplastic processes. Cartilaginous tumors of the head and neck are uncommon, posing a diagnostic challenge. Benign cartilaginous tumors that may occur in the head and neck include chondroma, chondroblastoma, chondromyxoid fibroma, osteochondroma, and synovial chondromatosis. Read More

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December 2021

[Pediatric SMARCB1/INI1-deficient poorly differentiated chordoma of the skull base: report of five cases and review of literature].

Zhonghua Bing Li Xue Za Zhi 2022 Jan;51(1):33-38

Department of Pathology, Sanbo Brain Institute, Capital Medical University, Beijing 100093, China.

To investigate the clinicopathological characteristics and differential diagnosis of pediatric SMARCB1/INI1-deficient poorly differentiated chordoma (PDC) of the skull base. Five cases of SMARCB1/INI1-deficient PDC were identified in 139 cases of chordoma diagnosed in Sanbo Brain Institute, Capital Medical University, Beijing, China from March 2017 to March 2021. The clinical and imaging data of the 5 PDCs were collected. Read More

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January 2022

Primary histiocytic sarcoma of the clivus with focal extension into central nervous system and neurologic manifestations: First description at an unusual site with an overwhelming and rapid progression.

Clin Neuropathol 2022 Mar-Apr;41(2):74-82

Histiocytic sarcoma (HS) is a rare malignant neoplasm of macrophage-dendritic cell lineage that can occur at any site. Primary base of skull involvement is exceedingly rare. We present the case of a previously healthy 56-year-old man who complained of headaches and showed localized neurologic symptoms. Read More

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Analysis of tumour microstructure estimation from conventional diffusion MRI and application to skull-base chordoma.

Annu Int Conf IEEE Eng Med Biol Soc 2021 11;2021:3761-3764

Skull-base chordoma (SBC) is a rare tumour whose molecular and radiological characteristics are still being investigated. In neuro-oncology microstructural imaging techniques, like diffusion-weighted MRI (DW-MRI), have been widely investigated, with the apparent diffusion coefficient (ADC) being one of the most used DW-MRI parameters due to its ease of acquisition and computation. ADC is a potential biomarker without a clear link to microstructure. Read More

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November 2021