1,483 results match your criteria Imaging in Chordoma


Clival Chordoma in an Adolescent: A Perspective from Primary Care.

Korean J Fam Med 2020 May 22. Epub 2020 May 22.

Department of Primary Care Medicine, Faculty of Medicine, Universiti Teknologi MARA, Batu Caves, Selangor, Malaysia.

Clival chordoma is a rare malignant tumor of the brain that typically occurs in older adults. It has a high local recurrence rate and is hence associated with poor prognosis. Here, we report a case of an adolescent who presented with a 1-month history of worsening headache and blurring of vision, as well as a 6-month history of left-sided facial and body numbness. Read More

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http://dx.doi.org/10.4082/kjfm.19.0004DOI Listing

Experience With the Endoscopic Contralateral Transmaxillary Approach to the Petroclival Skull Base.

Laryngoscope 2020 May 15. Epub 2020 May 15.

Center for Cranial Base Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA.

Objectives/hypothesis: The contralateral transmaxillary (CTM) approach is a new surgical approach that improves the surgical trajectory relative to the petrous segment of the internal carotid artery (ICA). Here, we present our clinical experience with the CTM approach to the petroclival region of the skull base.

Study Design: Retrospective review. Read More

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http://dx.doi.org/10.1002/lary.28740DOI Listing

Chondromyxoid Fibroma of the Sacral Spine.

Int J Surg Pathol 2020 May 4:1066896920916784. Epub 2020 May 4.

Rutgers New Jersey Medical School, Newark, NJ, USA.

. Chondromyxoid fibromas are rare tumors of cartilaginous origin typically found in long bones. They usually present during the second and third decades of life. Read More

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http://dx.doi.org/10.1177/1066896920916784DOI Listing

Post-traumatic Sacral Epidermoid Cyst Masquerading as Chordoma on Imaging: A Case Report.

JNMA J Nepal Med Assoc 2020 Mar;58(223):192-194

Department of Critical Care Medicine, B & C Medical College Teaching Hospital & Research Center, Birtamode, Jhapa, Nepal.

Intradural spinal epidermoid cysts are rare, benign lesions either acquired from trauma, surgery, lumbar puncture or arise as congenital lesions, particularly associated with spinal dysraphism. Epidermoid cyst arising from the spine with expansile destruction of vertebrae has not been reported yet in the literature. We report a case of 36-years male presented with history of fall 8 years back with progressive symptoms of lower back pain, weakness of left lower limb and bladder/bowel incontinence. Read More

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Advances in the management of primary bone sarcomas of the skull base.

J Neurooncol 2020 Apr 18. Epub 2020 Apr 18.

Departments of Neurosurgery, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

Skull base primary malignancies represent a heterogeneous group of histologic diagnoses and sarcomas of the skull base are specific malignant tumors that arise from mesenchymal cells and can be classified by site of origin into bony and soft tissue sarcomas. The most common bony sarcomas include: chondrosarcoma, osteosarcoma, chordoma, Ewing's sarcoma. Given the relative rarity of each histologic diagnosis, especially in the skull base, there is limited published data to guide the management of patients with skull base sarcomas. Read More

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http://dx.doi.org/10.1007/s11060-020-03497-6DOI Listing

Comparative proton versus photon treatment planning for the Medicare Medical Treatment Overseas Program: The Royal Adelaide Hospital experience.

J Med Imaging Radiat Oncol 2020 Apr 3. Epub 2020 Apr 3.

Department of Radiation Oncology, Royal Adelaide Hospital, Adelaide, South Australia, Australia.

Introduction: Australia's first proton beam therapy (PBT) service, The Australian Bragg Centre for Proton Therapy and Research, is scheduled to open in the near future providing PBT for patients closer to home. Patients currently access Commonwealth funding for PBT via the Medicare Medical Treatment Overseas Program (MTOP). Proton versus photon treatment planning is a pre-requisite for the MTOP application. Read More

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http://dx.doi.org/10.1111/1754-9485.13018DOI Listing
April 2020
0.951 Impact Factor

Expanded transnasal approaches to the skull base in the Middle East: Where do we stand?

Ann Saudi Med 2020 Mar-Apr;40(2):94-104. Epub 2020 Apr 2.

From the Division of Neurosurgery, College of Medicine, King Saud University, Riyadh, Saudi Arabia.

Background: Endoscopic transnasal surgery has gained rapid global acceptance over the last two decades. The growing literature and understanding of anterior skull base endoscopic anatomy, in addition to new dedicated endoscopic instruments and tools, have helped to expand the use of the transnasal route in skull base surgery.

Objective: Report our early experience in expanded endoscopic transnasal surgery (EETS) and approach to skull base neoplasms. Read More

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http://dx.doi.org/10.5144/0256-4947.2020.94DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7118227PMC
April 2020
0.705 Impact Factor

Salvage Free Tissue Transfer for Clival Osteoradionecrosis After Repeat Proton Beam Therapy.

World Neurosurg 2020 Mar 27;138:485-490. Epub 2020 Mar 27.

Department of Neurological Surgery, The Ohio State University, Wexner Medical Center, Columbus, Ohio, USA.

Background: Craniocervical junction chordoma treated with surgery and Proton Beam Therapy evolved with Osteonecrosis and CSF leak. As the vascularization of the head was compromised, we harvested an Anterolateral thigh musculofascial flap to seal the leak.

Case Description: A 56-year-old man presented with a history of chronic headaches and dysarthria with tongue deviation to the right. Read More

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http://dx.doi.org/10.1016/j.wneu.2020.03.108DOI Listing

Predictive role of Apparent Diffusion Coefficient (ADC) from Diffusion Weighted MRI in patients with sacral chordoma treated with carbon ion radiotherapy (CIRT) alone.

Eur J Radiol 2020 May 3;126:108933. Epub 2020 Mar 3.

Radiotherapy Unit, National Center of Oncology Hadrontherapy (CNAO), Pavia, Italy.

Purpose: To evaluate if baseline ADC from DWI sequences could predict response to treatment in patients with sacral chordoma not suitable for surgery treated with carbon ion radiotherapy (CIRT) alone compared with volume changes.

Methods: Fifty-nine patients with sacral chordoma not suitable for surgery underwent one cycle of CIRT alone and a minimum of 12-months follow-up. All patients underwent MRI before treatment (baseline), every three months in the first two years after treatment, and every six months afterwards. Read More

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http://dx.doi.org/10.1016/j.ejrad.2020.108933DOI Listing

Partial Sacrectomy for Resection of a Sacral Chordoma: 2-Dimensional Operative Video.

Oper Neurosurg (Hagerstown) 2020 Feb 26. Epub 2020 Feb 26.

Unidad de Patología Espinal, Hospital Español, Mendoza, Argentina.

Sacral chordomas are infrequent tumors that arise from remnants of the notochord. They are most often found in the sacrum and skull-base.1,2 These lesions rarely metastasize and usually have an indolent and oligosymptomatic clinical course. Read More

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http://dx.doi.org/10.1093/ons/opaa024DOI Listing
February 2020

Total Penectomy for Recurrent Chordoma of the Corpus Cavernosum.

Case Rep Urol 2020 13;2020:5498069. Epub 2020 Feb 13.

Department of Urology, Ludwig-Maximilians-University, Munich, Germany.

Chordomas are rare low malignant neoplasm arising from remnants of the notochord with predilection site of the clivus or the os sacrum. Standard therapy is radical excision and adjuvant radiation. Due to invasive growth and adjacent to vital structures resection is often incomplete, and therefore, local recurrence is frequent. Read More

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http://dx.doi.org/10.1155/2020/5498069DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7040421PMC
February 2020

Chondrosarcoma of the dorsal spine - A rare case.

J Craniovertebr Junction Spine 2019 Oct-Dec;10(4):250-253. Epub 2020 Jan 23.

Department of Pathology, Seth GSMC, Mumbai, Maharashtra, India.

Chondrosarcomas of the spine are rare tumors and represent <10% of all chondrosarcomas. In the spine, they may arise from vertebral bodies or posterior elements. They may occur in patients ranging from 13 to 78 years of age. Read More

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http://dx.doi.org/10.4103/jcvjs.JCVJS_100_19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7008663PMC
January 2020

Chordoma with lung metastases at initial presentation of a pediatric patient.

Radiol Case Rep 2020 Apr 5;15(4):382-386. Epub 2020 Feb 5.

Department of Diagnostic Imaging and Radiology, University of Missouri Hospital/ Women's and Children's Hospital, Columbia, MO, USA.

Chordomas are rare, slow growing malignant tumors derived from notochord remnants that can arise anywhere along the neuronal axis. Chordomas are particularly rare in patients under 20 years of age and tend to be intracranial in location, as opposed to sacrococcygeal in adults. Metastasis at initial presentation is uncommon in all age groups and is exceedingly rare in the absence of local recurrence of the primary tumor. Read More

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http://dx.doi.org/10.1016/j.radcr.2020.01.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7005512PMC

Extreme Lateral Transodontoid Approach for Resection of Clival Chordoma: 2-Dimensional Operative Video.

Oper Neurosurg (Hagerstown) 2020 Jan 15. Epub 2020 Jan 15.

Department of Neurosurgery, Clinical Neurosciences Center, University of Utah, Salt Lake City, Utah.

This 15-yr-old girl presented with nasal obstruction and dysphagia of duration 3 mo and 8 to 10 pounds of weight loss. On examination, she had a hoarse voice and left tongue deviation without weakness or myelopathy. Computed tomography (CT) demonstrated an erosive lesion arising from the clivus and left occipital condyle. Read More

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http://dx.doi.org/10.1093/ons/opz411DOI Listing
January 2020

A 72-year-old woman with periorbital swelling.

Allergy Asthma Proc 2020 01;41(1):e33-e36

As allergists, we are frequently consulted to evaluate patients with swelling presumed to be angioedema. Patients with presumed angioedema can have multiple possible underlying triggers. We present the case of a hospitalized 72-year-old woman with a history of hypertension and metastatic chordoma who developed marked periorbital swelling that precluded eye opening 2 days after a neurosurgical operation (chordoma resection and T10-11 hardware repair). Read More

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http://dx.doi.org/10.2500/aap.2020.41.190004DOI Listing
January 2020

Rectum Dose Constraints for Carbon Ion Therapy: Relative Biological Effectiveness Model Dependence in Relation to Clinical Outcomes.

Cancers (Basel) 2019 Dec 21;12(1). Epub 2019 Dec 21.

Clinical Department, Centro Nazionale di Adroterapia Oncologica, 27100, Pavia, Italy.

The clinical application of different relative biological effectiveness (RBE) models for carbon ion RBE-weighted dose calculation hinders a global consensus in defining normal tissue constraints. This work aims to update the local effect model (LEM)-based constraints for the rectum using microdosimetric kinetic model (mMKM)-defined values, relying on RBE translation and the analysis of long-term clinical outcomes. LEM-optimized plans of treated patients, having suffered from prostate adenocarcinoma ( = 22) and sacral chordoma ( = 41), were recalculated with the mMKM using an in-house developed tool. Read More

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http://dx.doi.org/10.3390/cancers12010046DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7016830PMC
December 2019

Aggressive, Multidisciplinary Staged Microsurgical Resection of a Giant Cervicomedullary Junction Chordoma.

J Neurol Surg B Skull Base 2019 Dec 4;80(Suppl 4):S378-S379. Epub 2019 Oct 4.

Department of Neurological Surgery, University of Wisconsin Medical School, Madison, Wisconsin, United States.

Chordomas of the cranial base are locally destructive tumors since they are surrounded by significant complex neurovascular structures. Thus, their surgical removal is challenging, recurrence rates are high, and their therapeutic strategies remain controversial. In this video, we present a 47-year-old man with a recent onset of swallowing difficulties, hoarseness, and weight loss for several weeks. Read More

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http://dx.doi.org/10.1055/s-0039-1695062DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6900546PMC
December 2019

C3-C5 Chordoma Resection and Reconstruction with a Three-Dimensional Printed Titanium Patient-Specific Implant.

World Neurosurg 2020 Apr 4;136:226-233. Epub 2019 Dec 4.

Faculty of Medicine, University of New South Wales, Sydney, Australia; Surgical and Orthopaedic Research Laboratories, Prince of Wales Clinical School, University of New South Wales, Sydney, Australia; NeuroSpine Surgery Research Group, Sydney, Australia; Department of Neurosurgery, Prince of Wales Private Hospital, Sydney, Australia.

Background: With this case report, we aim to add to the clinical literature on the use of three-dimensional printed patient-specific implants in spinal surgery, show the current state of the art in patient-specific implant device design, present thorough clinical and radiographic outcomes, and discuss the suitability of titanium alloy as an implant material for patients with cancer.

Case Description: A 45-year-old man presented with neck and left arm pain combined with shoulder weakness. Imaging revealed significant destruction of the C3-C5 vertebrae, and chordoma diagnosis was confirmed by biopsy. Read More

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http://dx.doi.org/10.1016/j.wneu.2019.11.167DOI Listing
April 2020
2.417 Impact Factor

The preliminary results of proton and carbon ion therapy for chordoma and chondrosarcoma of the skull base and cervical spine.

Radiat Oncol 2019 Nov 21;14(1):206. Epub 2019 Nov 21.

Department of Radiation Oncology, Shanghai Proton and Heavy Ion Center, 4365 Kangxin Road, Shanghai, 201315, China.

Purpose: To evaluate the short-term outcomes in terms of tumor control and toxicity of patients with skull base or cervical spine chordoma and chondrosarcoma treated with intensity-modulated proton or carbon-ion radiation therapy.

Methods: Between 6/2014 and 7/2018, a total of 91 patients were treated in our Center. The median age was 38 (range, 4-70) years. Read More

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http://dx.doi.org/10.1186/s13014-019-1407-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6869181PMC
November 2019
4 Reads
2.546 Impact Factor

Radial Forearm Free Tissue Transfer to Clival Defect.

J Neurol Surg B Skull Base 2019 Dec 31;80(Suppl 4):S380-S381. Epub 2019 Oct 31.

Department of Otolaryngology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States.

 Reconstruction of craniocervical junction (CCJ) defects after endoscopic endonasal skull base surgery (ESBS) remains challenging, despite advancements in vascularized intranasal and regional flaps. Microvascular free tissue transfers have revolutionized reconstruction in open skull base surgery but have been utilized rarely in ESBS. We describe the use of a radial forearm free flap (RFFF) for reconstruction of a recalcitrant CCJ defect after resection of a clival chordoma. Read More

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http://dx.doi.org/10.1055/s-0039-1700890DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6864404PMC
December 2019

Chordoma of the Craniocervical Junction: Endoscopic Endonasal Approach.

J Neurol Surg B Skull Base 2019 Dec 22;80(Suppl 4):S372-S374. Epub 2019 Oct 22.

Service de Neurochirurgie de Prof. Froelich, Université Paris Diderot, Hôpital Lariboisière, Assistance Publique-Hôpitaux de Paris, Paris, France.

 This study was aimed to achieve gross-total removal of a chordoma of the craniocervical junction via an endonasal approach ( Fig. 1 ). Fig. Read More

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http://dx.doi.org/10.1055/s-0039-1697979DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6864403PMC
December 2019

From the Occipital Condyle to the Sphenoid Sinus: Extradural Extension of the Far Lateral Transcondylar Approach with Endoscopic Assistance.

World Neurosurg 2020 Feb 14;134:e771-e782. Epub 2019 Nov 14.

Department of Neurosurgery, Lariboisière Hospital, Paris VII-Diderot University, Paris, France.

Background: Surgical management of extensive skull base tumors, such as chordoma and chondrosarcoma, remains very challenging. The need for gross total removal to improve survival must be weighed against the risk of injury to neurovascular structures and the loss of stability at the craniovertebral junction. In cases of tumors that are already compromising craniovertebral junction stability, the occipital condyle can be exploited as a deep keyhole to reach the clivus, petrous apex, and sphenoid sinus. Read More

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http://dx.doi.org/10.1016/j.wneu.2019.10.190DOI Listing
February 2020

Spontaneous regression of a clival chordoma. Case report.

Acta Neurochir (Wien) 2020 02 12;162(2):433-436. Epub 2019 Nov 12.

Department of Neurosurgery, Weill Cornell Medicine, New York Presbyterian Hospital, 525 East 68th St., Box 99, New York, NY, 10065, USA.

In this case report, we present a rare and previously unreported case of spontaneous regression of a histologically consistent clival chordoma. At the time of diagnosis, imaging demonstrated a T2 hyperintense and T1 isointense midline skull base mass, centered in the nasopharynx, with scalloping of the ventral clivus consistent with a chordoma measuring 3.1 × 1. Read More

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http://dx.doi.org/10.1007/s00701-019-04107-9DOI Listing
February 2020
4 Reads

Pharmacokinetic Analysis of [18F]FAZA Dynamic PET Imaging Acquisitions for Highlighting Sacrum Tumor Profiles.

Clin Nucl Med 2020 Jan;45(1):e36-e38

From the Department of Medical Imaging, Nuclear Medicine, Institut Curie, Saint-Cloud.

A patient enrolled in a clinical trial (NCT02802969) with suspicion of chordoma underwent an [F]FAZA PET/CT, a radiolabeled nitroimidazole analog of hypoxia PET imaging. The patient's images showed a different tumor profile compared to those observed in other hypoxic or nonhypoxic chordoma patients. The motivation for using [F]FAZA pharmacokinetic imaging was to compare this profile with histologically confirmed cases of chordoma. Read More

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http://dx.doi.org/10.1097/RLU.0000000000002813DOI Listing
January 2020

Radiomic signature: A novel magnetic resonance imaging-based prognostic biomarker in patients with skull base chordoma.

Radiother Oncol 2019 12 25;141:239-246. Epub 2019 Oct 25.

Engineering Research Center of Molecular and Neuro Imaging of Ministry of Education, School of Life Science and Technology, Xidian University, Xi'an, China; CAS Key Laboratory of Molecular Imaging, Institute of Automation, Chinese Academy of Sciences, Beijing, China; School of Artificial Intelligence, University of Chinese Academy of Sciences, Beijing, China; Beijing Advanced Innovation Center for Big Data-Based Precision Medicine, School of Medicine, Beihang University, Beijing, China. Electronic address:

Background And Purpose: We used radiomic analysis to establish a radiomic signature based on anatomical magnetic resonance imaging (MRI) sequences and explore its effectiveness as a novel prognostic biomarker for skull base chordoma (SBC).

Materials And Methods: In this retrospective study, radiomic analysis was performed using preoperative axial T FLAIR, T-weighted, and enhanced T FLAIR from a single hospital. The primary clinical endpoint was progression-free survival. Read More

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http://dx.doi.org/10.1016/j.radonc.2019.10.002DOI Listing
December 2019
2 Reads

Primary Chordoma of the Nasopharynx: A Rare Case Report and Review of the Literatures.

Case Rep Pathol 2019 23;2019:3826521. Epub 2019 Sep 23.

Department of Pathology and Laboratory Medicine, Istishari Hospital, Amman, Jordan.

Primary chordoma of the nasopharynx is an extremely rare malignant tumor of notochordal origin in the extra-osseous axial skeleton. It presents as a soft tissue mass without involvement of the skull base bone (clivus) and may mimic other lesions of the nasopharynx. A 26-year-old male patient is presented with nasal obstruction and congestion for the last 3 years. Read More

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http://dx.doi.org/10.1155/2019/3826521DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6778900PMC
September 2019

Peculiar pathological, radiological and clinical features of skull-base de-differentiated chordomas. Results from a referral centre case-series and literature review.

Histopathology 2020 Apr 10;76(5):731-739. Epub 2020 Mar 10.

Department of Biomedical and Neuromotor Sciences (DIBINEM), University of Bologna, Bologna, Italy.

Aims: De-differentiated chordoma is an uncommon and incompletely characterised aggressive neoplasm. Only a few cases originating from the skull base have been reported.

Methods And Results: All consecutive cases of skull-base de-differentiated chordomas treated surgically in a referral centre from January 1990 to June 2019 were retrospectively evaluated to assess peculiar pathological, radiological and clinical features. Read More

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http://dx.doi.org/10.1111/his.14024DOI Listing

[Anesthesia management of cervical chordoma resection: A case report].

Beijing Da Xue Xue Bao Yi Xue Ban 2019 Oct;51(5):981-983

Department of Anaesthesiology, Peking University Third Hospital, Beijing 100191, China.

Chordoma is a slow-growing, locally invasive, lowgrade malignant tumor with a prevalence of one in 100 000, accounting for 1%-4% of all malignant bone tumors. At present, it is considered that chordoma originates from ectopic embryonic chordal tissue and can occur in any part of the spine from the skull base to the sacrum. About 50% of chordoma occurs in the sacrococcygeal region, about 30% in the skull base, and the rest occurs in the active spinal region. Read More

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October 2019
5 Reads

Development and Validation of Single Field Multi-Ion Particle Therapy Treatments.

Int J Radiat Oncol Biol Phys 2020 01 11;106(1):194-205. Epub 2019 Oct 11.

Heidelberg Ion-Beam Therapy Center (HIT), Department of Radiation Oncology, Heidelberg University Hospital, Heidelberg, Germany; National Centre of Oncological Hadrontherapy (CNAO), Medical Physics, Pavia, Italy. Electronic address:

Purpose: To develop and validate combined ion-beam with constant relative biological effectiveness (RBE) (CICR) particle therapy in single field arrangements for improved treatment efficacy, robustness, and normal tissue sparing.

Methods And Materials: The PRECISE (PaRticle thErapy using single and Combined Ion optimization StratEgies) treatment planning system was developed to investigate clinical viability of CICR treatments. Single-field uniform dose (SFUD) with a single ion (proton [p], helium [He], or carbon [C]) and CICR (C-p and C-He) treatments were generated for 3 patient cases with a clinically prescribed dose of 3 Gy (RBE) per fraction. Read More

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http://dx.doi.org/10.1016/j.ijrobp.2019.10.008DOI Listing
January 2020

Extensive sphenoid chordoma mimicking a prolactinoma.

Pan Afr Med J 2019 24;33:138. Epub 2019 Jun 24.

Internal Medicine Department « A », University of Tunis El Manar, Tunis, Tunisia.

The chordoma is a benign cartilaginous tumor whose sphenoidale localization is exceptional. This tumor has considerable difficulties of both diagnosis and treatment. We report the observation of a Tunisian adult who presented features of hypopituitarism set wrongly on account of a prolactinoma. Read More

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http://dx.doi.org/10.11604/pamj.2019.33.138.12897DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6754828PMC
October 2019
2 Reads

Benign notochordal cell tumor of the clivus with chordoma component: report of 2 cases.

J Neurosurg 2019 Sep 13:1-5. Epub 2019 Sep 13.

Departments of1Neurosurgery.

Benign notochordal cell tumors (BNCTs) are considered to be benign intraosseous lesions of notochord origin; however, recent spine studies have suggested the possibility that some chordomas arise from BNCTs. Here, the authors describe two cases demonstrating histological features of BNCT and concomitant chordoma involving the clivus, which, to the best of the authors' knowledge, have not been previously documented at this anatomical site.An 18-year-old female presented with an incidentally discovered clival mass. Read More

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https://thejns.org/view/journals/j-neurosurg/aop/article-10.
Publisher Site
http://dx.doi.org/10.3171/2019.6.JNS19529DOI Listing
September 2019
2 Reads

Long and Very-Long-Chain Ceramides Correlate with A More Aggressive Behavior in Skull Base Chordoma Patients.

Int J Mol Sci 2019 Sep 11;20(18). Epub 2019 Sep 11.

Department of Neurosurgery, Fondazione IRCCS Istituto Neurologico "Carlo Besta", 20133 Milan, Italy.

Background: Skull base chordomas are rare tumors arising from notochord. Sphingolipids analysis is a promising approach in molecular oncology, and it has never been applied in chordomas. Our aim is to investigate chordoma behavior and the role of ceramides. Read More

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http://dx.doi.org/10.3390/ijms20184480DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6769603PMC
September 2019
2.862 Impact Factor

The Relationship Between Tumor-Stroma Ratio, the Immune Microenvironment, and Survival in Patients With Spinal Chordoma.

Neurosurgery 2019 12;85(6):E1095-E1110

Department of Spine Surgery, The Second Xiangya Hospital, Central South, University, Changsha, China.

Background: Currently, little is known about the clinical relevance of tumor-stroma ratio (TSR) in chordoma and data discussing the relationship between TSR and immune status of chordoma are lacking.

Objective: To characterize TSR distribution in spinal chordoma, and investigated its correlation with clinicopathologic or immunological features of patients and outcome.

Methods: TSR was assessed visually on hematoxylin and eosin-stained sections from 54 tumor specimens by 2 independent pathologists. Read More

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http://dx.doi.org/10.1093/neuros/nyz333DOI Listing
December 2019
5 Reads
3.620 Impact Factor

Surgical treatment of giant chordoma in the thoracic spine combining thoracoscopic and posterior spinal surgery: A case report.

Medicine (Baltimore) 2019 Aug;98(35):e16990

Department of Orthopaedic Surgery, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences.

Rationale: Giant thoracic chordoma is a highly unusual disease with no standard curative managements yet. The objective of this study is to report a very rare case of giant thoracic chordoma successfully operated by combination of thoracoscopic surgery together with posterior spinal surgery. The management of these unique cases has yet to be well-documented. Read More

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http://dx.doi.org/10.1097/MD.0000000000016990DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6736088PMC
August 2019
1 Read

Clivus Intraosseous Meningioma Mimicking Chordoma.

J Craniofac Surg 2019 Nov-Dec;30(8):e755-e757

Department of Accident and Emergency, Faculty of Medicine, Jordan University of Science and Technology, Irbid, Jordan.

A 78-year-old woman with progressive worsening vertigo and new onset of diplopia. Neurological examination revealed bilateral abducens nerve paralysis and gait disturbance with truncal ataxia. Neuroimaging revealed a mass lesion within the clivus with brain stem compression. Read More

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http://dx.doi.org/10.1097/SCS.0000000000005843DOI Listing
January 2020
3 Reads

Primary maxillofacial chordoma: a rare case report and literature review.

J Int Med Res 2019 Sep 23;47(9):4575-4579. Epub 2019 Aug 23.

Department of Otolaryngology Head and Neck Surgery, the First Hospital of Jilin University, Changchun, P. R. China.

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http://dx.doi.org/10.1177/0300060519866280DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6753576PMC
September 2019
1 Read

Radiomic analysis of multiparametric magnetic resonance imaging for differentiating skull base chordoma and chondrosarcoma.

Eur J Radiol 2019 Sep 5;118:81-87. Epub 2019 Jul 5.

CAS Key Laboratory of Molecular Imaging, Institute of Automation, Chinese Academy of Sciences, Beijing, 100190, China; University of Chinese Academy of Sciences, Beijing, 100080, China; School of Life Science and Technology, Xidian University, Xi'an, Shaanxi, 710071, China; Beijing Advanced Innovation Center for Big Data-Based Precision Medicine, School of Medicine, Beihang University, Beijing, China. Electronic address:

Purpose: Patients with skull base chordoma and chondrosarcoma have different prognoses and are not readily differentiated preoperatively on imaging. Multiparametric magnetic resonance imaging (MRI) is a routine diagnostic tool that can noninvasively characterize the salient characteristics of tumors. In the present study, we developed and validated a preoperative multiparametric MRI-based radiomic signature for differentiating these tumors. Read More

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http://dx.doi.org/10.1016/j.ejrad.2019.07.006DOI Listing
September 2019
4 Reads

The impact of proton LET/RBE modeling and robustness analysis on base-of-skull and pediatric craniopharyngioma proton plans relative to VMAT.

Acta Oncol 2019 Dec 20;58(12):1765-1774. Epub 2019 Aug 20.

Department of Medical Physics and Biomedical Engineering, University College London, London, United Kingdom.

Pediatric craniopharyngioma, adult base-of-skull sarcoma and chordoma cases are all regarded as priority candidates for proton therapy. In this study, a dosimetric comparison between volumetric modulated arc therapy (VMAT) and intensity modulated proton therapy (IMPT) was first performed. We then investigated the impact of physical and biological uncertainties. Read More

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http://dx.doi.org/10.1080/0284186X.2019.1653496DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6882303PMC
December 2019
4 Reads

Role of diffusion-weighted imaging in monitoring treatment response following high-intensity focused ultrasound ablation of recurrent sacral chordoma.

Radiol Case Rep 2019 Oct 1;14(10):1197-1201. Epub 2019 Aug 1.

Department of Neurosurgery, John Radcliffe Hospital, Headley Way, Oxford, UK.

Chordoma is the most common malignant tumor of the sacrum and is associated with significant neurologic morbidity. Local recurrence is very common, and the long-term prognosis is poor. High-intensity focused ultrasound (HIFU) is a noninvasive and nonionising ablative therapy that has been successful in treating other tumor types and is being evaluated as a new therapy for sacral chordoma. Read More

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http://dx.doi.org/10.1016/j.radcr.2019.07.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6698304PMC
October 2019
6 Reads

Systematic Review of Clinical, Radiologic, and Histologic Features of Benign Notochordal Cell Tumors: Implications for Patient Management.

World Neurosurg 2019 Oct 14;130:13-23. Epub 2019 Jun 14.

Victor Horsley Department of Neurosurgery, The National Hospital for Neurology and Neurosurgery, Queen Square, London.

Background: There are no absolute defining criteria for benign notochordal cell tumors; the diagnosis is usually based on small size and the absence of aggressive features. Therefore, by definition, the diagnosis is subjective and usually determined by multidisciplinary consensus. A benign notochordal cell tumor should not grow during surveillance, and this may be used to confirm the diagnosis, but is a tautologic definition. Read More

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http://dx.doi.org/10.1016/j.wneu.2019.06.009DOI Listing
October 2019

Clinical-radiomics nomograms for pre-operative differentiation of sacral chordoma and sacral giant cell tumor based on 3D computed tomography and multiparametric magnetic resonance imaging.

Br J Radiol 2019 Sep 9;92(1101):20190155. Epub 2019 Jul 9.

1Department of Radiology, Peking University People's Hospital, 11 Xizhimen Nandajie, Xicheng District, Beijing, 100044, PR China.

Objective: To develop and validate clinical-radiomics nomograms based on three-dimensional CT and multiparametric MRI (mpMRI) for pre-operative differentiation of sacral chordoma (SC) and sacral giant cell tumor (SGCT).

Methods: A total of 83 SC and 54 SGCT patients diagnosed through surgical pathology were retrospectively analyzed. We built six models based on CT, CT enhancement (CTE), weighted, weighted, diffusion-weighted imaging (DWI), and contrast-enhanced weighted features, two radiomics nomograms and two clinical-radiomics nomograms combined radiomics mixed features with clinical data. Read More

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http://dx.doi.org/10.1259/bjr.20190155DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6732930PMC
September 2019
6 Reads

The Degree of Middle and Lower Clivus Invasion by Chordoma is Linked to Patient Prognosis Via Ki-67 Value.

World Neurosurg 2019 Oct 29;130:e620-e626. Epub 2019 Jun 29.

Department of Neurosurgery, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning, People's Republic of China. Electronic address:

Objective: The aim of this study was to discuss the relationship between Ki-67 values and the degree to which chordoma invade the clivus and to certify that the prognosis of chordoma is worse when it invades the middle and lower clivus than when it does not.

Methods: We collected 56 cases of first-time chordoma illness in which patients received no treatment before surgery. Patients underwent craniocerebral magnetic resonance imaging and skull-base 3-dimensional computed tomography scans before the operation. Read More

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http://dx.doi.org/10.1016/j.wneu.2019.06.173DOI Listing
October 2019
19 Reads

An unusual presentation of clival chordoma: a case report and review of the literature.

Br J Neurosurg 2019 Jun 21:1-3. Epub 2019 Jun 21.

b Department of Neurosurgery , Aberdeen Royal Infirmary , Aberdeen , UK.

Chordomas are rare bone tumours that are aggressive and locally invasive. When arising from the clivus, they typically present with cranial nerve deficits and headache. We report a case of a 58-year-old male who presented acutely with hydrocephalus and suspected encephalitis. Read More

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http://dx.doi.org/10.1080/02688697.2019.1630548DOI Listing
June 2019
6 Reads

Unexpected benefit from an 'old' metronomic chemotherapy regimen in advanced chordoma.

BMJ Case Rep 2019 Jun 2;12(6). Epub 2019 Jun 2.

Medical Oncology, Universita Campus Bio-Medico di Roma, Roma, Lazio, Italy.

In this case report, we describe an older adult man affected by advanced chordoma progressing after treatment with cisplatin and imatinib. The patient was symptomatic for uncontrolled pain. We decided to treat the patient with metronomic cyclophosphamide, unexpectedly achieving long-lasting clinical and radiological benefit. Read More

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http://dx.doi.org/10.1136/bcr-2018-228728DOI Listing
June 2019
11 Reads

A Rare Presentation of Axial Chordoma and the Approach to Management.

Am J Case Rep 2019 Jun 1;20:773-775. Epub 2019 Jun 1.

Department of Plastic Surgery, Hamad Medical Corporation, Doha, Qatar.

BACKGROUND Chordoma is a primary bone tumor that most commonly arises in the sacrococcygeal vertebrae and the spheno-occipital areas. Chordoma is a malignant tumor that should be distinguished from benign notochordal cell tumor (BNCT) of the spine. This report is of a rare case of axial chordoma and describes the challenging approach to diagnosis and management. Read More

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http://dx.doi.org/10.12659/AJCR.913678DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6561141PMC
June 2019
6 Reads

Occasionally report of sacral chordoma; treatment and review of literature.

G Chir 2019 Mar-Apr;40(2):132-136

Introduction: Brain notochordal cell tumors (BTCN) are lesions arising from notochordal differentiation which affect the axial skeleton.

Presentation Of Case: We report a case of a patient treated in our General Surgery Unit of the University Hospital of Bari, Italy, with occasional finding of sacral chordoma at the histological examination.

Discussion: Because of their location, sacral chordomas can affect bowel and bladder with organ specific symptoms. Read More

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January 2020
11 Reads

Chordoma located in the jugular foramen: Case report.

Medicine (Baltimore) 2019 May;98(21):e15713

Department of Otorhinolaryngology Head and Neck Surgery.

Rationale: Chordomas are rare malignant neoplasms arised from residual embryonic notochordal tissue, mostly located in the axial midline. Tumors along extra-axial locations in the head and neck are rare. Chordomas located in the jugular foramen are extremely rare, with a low incidence of 0. Read More

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http://dx.doi.org/10.1097/MD.0000000000015713DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6571403PMC
May 2019
10 Reads

Carbon ions therapy as single treatment in chordoma of the sacrum. Histologic and metabolic outcome studies.

Eur Rev Med Pharmacol Sci 2019 May;23(9):4002-4009

Oncologic and Degenerative Spine Surgery Unit, IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy.

Objective: Even though carbon ions treatment (CIRT) of sacral chordoma (SC) substantially reduces tumor mass, tumor remnants are observed in most patients. Differentiating tumor remnants from necrosis is challenging, expensive in terms of imaging and time-consuming. So far, there has not been a systematic histological and metabolic analysis of post-CIRT lesions. Read More

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http://dx.doi.org/10.26355/eurrev_201905_17830DOI Listing
May 2019
2 Reads

Intra-articular extra-axial chordoma of the wrist: a case report with review of the current literature.

Skeletal Radiol 2019 Dec 18;48(12):2015-2020. Epub 2019 May 18.

Department of Diagnostic and Interventional Radiology, Technical University of Munich, Ismaninger Strasse 22, 81675, Munich, Germany.

Chordomas are rare bone malignancies that are thought to arise from remnants of the notochord and usually are located in the axial skeleton. Immunophenotypical matching neoplasms primarily found in appendicular locations, referred to as extra-axial chordoma, are rarely encountered by radiologists, surgeons, and pathologists. Only a few of these cases have been described in the literature with only one intra-articular case with involvement of the knee joint. Read More

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http://dx.doi.org/10.1007/s00256-019-03228-7DOI Listing
December 2019
17 Reads

Proton therapy for brain tumours in the area of evidence-based medicine.

Br J Radiol 2020 Mar 20;93(1107):20190237. Epub 2019 May 20.

Center for Proton Therapy, Paul Scherrer Institute, Villigen, Switzerland.

Advances In Knowledge: This review details the indication of brain tumors for proton therapy and give a list of the open prospective trials for these challenging tumors. Read More

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http://dx.doi.org/10.1259/bjr.20190237DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7066950PMC
March 2020
1 Read
1.533 Impact Factor