1,403 results match your criteria Imaging in Chordoma


The significance of intraoperative magnetic resonance imaging in resection of skull base chordomas.

World Neurosurg 2019 Apr 16. Epub 2019 Apr 16.

International Neuroscience Institute Rudolf-Pichlmayr-Straße 4 D - 30625 Hannover Germany.

Background: Skull base chordoma could be a challenging surgical entity due to its invasive nature.

Objective: In this study, we are evaluating the role of intraoperative magnetic resonance imaging to optimize the resection of skull base chordomas METHODS: We performed a retrospective analysis of the operated patients with skull base chordomas in the setting of iMRI. The clinical records, operative notes, radiological images, tumor volumetry, location of the residual tumor, and surgical outcome have been evaluated. Read More

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http://dx.doi.org/10.1016/j.wneu.2019.04.086DOI Listing

Imaging of Malignant Primitive Tumors of the Spine.

J Belg Soc Radiol 2018 Sep 6;102(1):56. Epub 2018 Sep 6.

Institut Kassab of Orthopaedics, TN.

Primary malignant tumors of the spine are rare and mainly include chordoma, chondrosarcoma, Ewing sarcoma or primitive neuroectodermal tumor, and osteosarcoma. The final diagnosis is based on the combination of patient age, topographic and histologic features of the tumor, and lesion pattern on computed tomography (CT) and magnetic resonance (MR) imaging. Imaging evaluation includes radiography, CT, bone scintigraphy, and MR imaging. Read More

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http://dx.doi.org/10.5334/jbsr.1410DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6425224PMC
September 2018
1 Read

Novel approach using ultrasonic bone curettage and transoral robotic surgery for en bloc resection of cervical spine chordoma: case report.

J Neurosurg Spine 2019 Mar 1:1-6. Epub 2019 Mar 1.

1University of Pennsylvania Perelman School of Medicine, Department of Neurological Surgery.

Chordomas are rare, locally aggressive neoplasms that develop from remnants of the notochord. The typical approach to chordomas of the clivus and axial cervical spine often limits successful en bloc resection. In this case report, authors describe the first-documented transoral approach using both transoral robotic surgery (TORS) for exposure and the Sonopet bone scalpel under navigational guidance to achieve en bloc resection of a cervical chordoma. Read More

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http://dx.doi.org/10.3171/2018.11.SPINE181162DOI Listing
March 2019
8 Reads

Maximizing Sacral Chordoma Resection by Precise 3-Dimensional Tumor Modeling in the Operating Room Using Intraoperative Computed Tomography Registration with Preoperative Magnetic Resonance Imaging Fusion and Intraoperative Neuronavigation: A Case Series.

World Neurosurg 2019 Feb 18. Epub 2019 Feb 18.

Warren Alpert Medical School of Brown University, Rhode Island Hospital, Providence, Rhode Island, USA. Electronic address:

Introduction: The primary treatment for patients with sacral chordoma is en bloc surgical resection with negative margins, which has been shown to reduce local recurrence and tumor-related morbidity. Here we describe the use of intraoperative neuronavigation using preoperative spine magnetic resonance imaging fused to intraoperative computed tomography (CT) to create 3-dimensional tumor reconstructions in the operating room for intraoperative identification of bone and soft-tissue margins for maximal safe tumor resection.

Methods: A single-institution retrospective chart review was completed to encompass our experience of 6 consecutive patients who had sacral chordoma resections using our described navigation protocol. Read More

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http://dx.doi.org/10.1016/j.wneu.2019.01.257DOI Listing
February 2019
2 Reads

A step towards international prospective trials in carbon ion radiotherapy: investigation of factors influencing dose distribution in the facilities in operation based on a case of skull base chordoma.

Radiat Oncol 2019 Feb 1;14(1):24. Epub 2019 Feb 1.

Service de Cancérologie-Radiothérapie, Hôpital A.Michallon, CHU de Grenoble, Grenoble, France.

Background: Carbon ion radiotherapy (CIRT) has been delivered to more than 20,000 patients worldwide. International trials have been recommended in order to emphasize the actual benefits. The ULICE program (Union of Light Ion Centers in Europe) addressed the need for harmonization of CIRT practices. Read More

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http://dx.doi.org/10.1186/s13014-019-1224-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6359776PMC
February 2019
3 Reads

Review of first clinical experiences with a 1.5 Tesla ceiling-mounted moveable intraoperative MRI system in Europe.

Bosn J Basic Med Sci 2019 Feb 12;19(1):24-30. Epub 2019 Feb 12.

Department of Neurosurgery, University of Tuebingen Medical Center, Germany.

High-field intraoperative MRI (iMRI) systems provide excellent imaging quality and are used for resection control and update of image guidance systems in a number of centers. A ceiling-mounted intraoperative MRI system has several advantages compared to a conventional iMRI system. In this article, we report on first clinical experience with using such a state-of-the-art, the 1. Read More

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http://dx.doi.org/10.17305/bjbms.2018.3777DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6387677PMC
February 2019
4 Reads

Radiation-Induced Moyamoya Syndrome After Proton Therapy in Child with Clival Chordoma: Natural History and Surgical Treatment.

World Neurosurg 2019 Mar 22;123:306-309. Epub 2018 Dec 22.

Department of Neurosurgery, IRCCS Istituto Giannina Gaslini, Via Gerolamo Gaslini, Genoa, Italy.

Background: Proton therapy has proven to be effective and safe in the treatment of radioresistant skull base tumors such as chordomas. Thanks to the peculiar physical properties of the proton beam, radiation energy is delivered in a narrow space called the Bragg peak and the surrounding normal tissues receive a minimal amount of the radiation dose. This is important to lower the risk of radiation-induced damage, especially in children. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S18788750183287
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http://dx.doi.org/10.1016/j.wneu.2018.12.048DOI Listing
March 2019
26 Reads

Giant sacrococcygeal chordoma: A case report.

Medicine (Baltimore) 2018 Dec;97(51):e13748

Department of Orthopedics, Artificial Joints Engineering and Technology Research Center of Jiangxi Province, The First Affiliated Hospital of Nanchang University, Nanchang.

Rationale: Chordoma is a relatively rare tumor that accounts for 1% to 4% of all malignant bone tumors, with an annual incidence of <0.1 per 100,000 people. Although chordoma is aligned with the axis of the spine and most commonly develops in the sacrum, to the best of our knowledge, giant sacrococcygeal chordoma is extremely rare. Read More

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http://Insights.ovid.com/crossref?an=00005792-201812210-0009
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http://dx.doi.org/10.1097/MD.0000000000013748DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6320187PMC
December 2018
5 Reads
5.723 Impact Factor

Predictive Value of Preoperative Magnetic Resonance Imaging Findings for Survival and Local Recurrence in Patients Undergoing En Bloc Resection of Sacral Chordomas.

Neurosurgery 2018 Dec 12. Epub 2018 Dec 12.

Department of Neurological Surgery, The University of Texas MD Anderson Cancer Center, Houston, Texas.

Background: Few studies have assessed the prognostic importance of preoperative magnetic resonance imaging (MRI) scan findings in patients undergoing en bloc resection of sacral chordomas.

Objective: To (1) report in-depth imaging characteristics of sacral chordomas, (2) describe the patterns of local and distant recurrence, and (3) determine imaging predictors of overall survival (OS) and local recurrence (LR).

Methods: This retrospective case series was obtained from a prospectively maintained spine database from 1995 to 2016. Read More

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https://academic.oup.com/neurosurgery/advance-article/doi/10
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http://dx.doi.org/10.1093/neuros/nyy578DOI Listing
December 2018
4 Reads

Chordoma of the corpus callosum: case report.

J Neurosurg 2018 Nov 1:1-7. Epub 2018 Nov 1.

Departments of1Neurosurgery.

Chordomas are neoplasms that typically arise from midline skeletal structures and rarely originate within the intradural compartment of the CNS. A chordoma arising from the corpus callosum has not been previously described. The authors report the surgical management of a chordoma originating within the splenium of the corpus callosum. Read More

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http://dx.doi.org/10.3171/2018.6.JNS181028DOI Listing
November 2018
25 Reads

Gamma Knife Management of Skull Base Chordomas: Is it a Choice?

Asian J Neurosurg 2018 Oct-Dec;13(4):1037-1041

Department of Neurosurgery, Mansoura University Hospital, Mansoura, International Medical Center, Cairo, Egypt.

Background: Skull base chordomas are locally invasive tumors which able to extend in different directions with skull base invasion. Although they are histologically benign, they have invasive nature makes total resection virtually impossible to achieve in most cases and this lead to residual tumors after surgery. To decrease postoperative surgical resection morbidity of these tumors, gamma knife radiosurgery (GKRS) was performed as alternative management for these residual chordomas to evaluate its safety and efficacy. Read More

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http://dx.doi.org/10.4103/ajns.AJNS_61_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6208200PMC
November 2018
23 Reads

A Novel MRI-Based Radiomics Model for Predicting Recurrence in Chordoma.

Conf Proc IEEE Eng Med Biol Soc 2018 07;2018:139-142

Chordoma is a rare primary malignant tumor. For evaluating the related factors of postoperative recurrence probability of chordoma before surgery, we retrospective collected 80 patients to analyze by using a novel radiomics method. A total of 620 3D imaging features used for radiomics analysis were extracted, and 5 features were selected from T2-weighted (T2-w) magnetic resonance imaging (MRI) that were most strongly associated with 4-year recurrence probability to build a radiomics signature. Read More

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https://ieeexplore.ieee.org/document/8512207/
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http://dx.doi.org/10.1109/EMBC.2018.8512207DOI Listing
July 2018
15 Reads

A Triple-Classification Radiomics Model for the Differentiation of Primary Chordoma, Giant Cell Tumor, and Metastatic Tumor of Sacrum Based on T2-Weighted and Contrast-Enhanced T1-Weighted MRI.

J Magn Reson Imaging 2019 Mar 14;49(3):752-759. Epub 2018 Nov 14.

Department of Radiology, Peking University People's Hospital, Beijing, P. R. China.

Background: Preoperative differentiation between primary sacral chordoma (SC), sacral giant cell tumor (SGCT), and sacral metastatic tumor (SMT) is important for treatment decisions.

Purpose: To develop and validate a triple-classification radiomics model for the preoperative differentiation of SC, SGCT, and SMT based on T2-weighted fat saturation (T2w FS) and contrast-enhanced T1-weighted (CE T1w) MRI.

Study Type: Retrospective. Read More

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http://doi.wiley.com/10.1002/jmri.26238
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http://dx.doi.org/10.1002/jmri.26238DOI Listing
March 2019
10 Reads

Rare case of neglected large sacral Chordoma in a young female treated by wide En bloc resection and Sacrectomy.

BMC Cancer 2018 Nov 14;18(1):1112. Epub 2018 Nov 14.

Department of Orthopaedics, Hospital Sultan Ismail, Johor Bahru, Malaysia.

Background: Sacral chordoma is a locally aggressive malignant tumour originating from ectopic notochordal cells. The natural history of sacral chordoma is a slow growing tumour arising at the midline of the lower sacrum that can invade the sacrum and progressively increase in size expanding cranially and anteriorly. Metastasis is very rare even when the tumour is large. Read More

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http://dx.doi.org/10.1186/s12885-018-5012-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6234700PMC
November 2018
16 Reads

Differential Diagnosis and Treatment Modality of Parasellar Plasmacytoma: Clinical Series and Literature Review.

World Neurosurg 2019 Feb 7;122:e978-e988. Epub 2018 Nov 7.

Beijing Neurosurgical Institute, Capital Medical University, Beijing, China.

Background: Parasellar plasmacytomas are rare tumors arising from the sellar region that should be considered in the differential diagnosis of lesions involving the sella and clivus. Before surgical pathologic examination, parasellar plasmacytomas have often been misdiagnosed as invasive pituitary adenomas or chordomas owing to the similarity of the clinical presentation and imaging findings.

Methods: We retrospectively reviewed the data from 5 patients with parasellar plasmacytoma who underwent endonasal endoscopic tumor resection in Beijing Tiantan Hospital from January 2008 to January 2018. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S18788750183249
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http://dx.doi.org/10.1016/j.wneu.2018.10.183DOI Listing
February 2019
14 Reads

Giant Recurrent Sacral Chordoma.

World Neurosurg 2019 Feb 2;122:96-97. Epub 2018 Nov 2.

Department of Neurosurgery, Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua University, Beijing, China. Electronic address:

A 65-year-old man presented with a giant recurrent sacral chordoma after undergoing 7 surgical resections. Neurologic examination revealed urinary incontinence. Magnetic resonance imaging showed a huge mass lesion in the bilateral gluteal regions and multiple metastatic chordomas. Read More

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http://dx.doi.org/10.1016/j.wneu.2018.10.165DOI Listing
February 2019

Benign notochordal cell tumour: clinicopathology and molecular profiling of 13 cases.

J Clin Pathol 2019 Jan 24;72(1):66-74. Epub 2018 Oct 24.

Department of Neuropathology, Beijing Neurosurgical Institute, Beijing Tiantan Hospital, Capital Medical University, China National Clinical Research Center for Neurological Diseases (NCRC-ND), Center of Brain Tumor, Beijing Institute for Brain Disorders, Beijing Key Laboratory of Brain Tumor, Beijing, China

Aims: To study the clinicopathological and molecular features of benign notochordal cell tumours (BNCTs) and their differential diagnosis from chordoma.

Methods: 13 cases of BNCT were investigated. The genome-wide copy number imbalances were performed using Oncoscan CNV array in three cases and fluorescence in situ hybridisation (FISH) detection of epidermal growth factor receptor (EGFR)/chromosome 7 enumeration probe (CEP7), LSI1p36/1q21, LSI19p13/19q13, CEP3/CEP12 and Telvysion 6 P was performed in 13 cases. Read More

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http://dx.doi.org/10.1136/jclinpath-2018-205441DOI Listing
January 2019
7 Reads

Photopsia, an unusual manifestation of optic chiasm compression by sphenoid sinus chodorma.

Kaohsiung J Med Sci 2018 10 29;34(10):590-592. Epub 2018 Mar 29.

Department of Ophthalmology, Changhua Christian Hospital, Changhua city, Taiwan; Department of Optometry, Da-Yeh University, Changhua City, Taiwan. Electronic address:

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http://dx.doi.org/10.1016/j.kjms.2018.03.003DOI Listing
October 2018
3 Reads

Comparison of radiomics machine-learning classifiers and feature selection for differentiation of sacral chordoma and sacral giant cell tumour based on 3D computed tomography features.

Eur Radiol 2019 Apr 2;29(4):1841-1847. Epub 2018 Oct 2.

Department of Radiology, Peking University People's Hospital, 11 Xizhimen Nandajie, Xicheng District, Beijing, 100044, People's Republic of China.

Objective: We aimed to identify optimal machine-learning methods for preoperative differentiation of sacral chordoma (SC) and sacral giant cell tumour (SGCT) based on 3D non-enhanced computed tomography (CT) and CT-enhanced (CTE) features.

Methods: A total of 95 patients were divided into a training set and a validation set. Three best feature selection methods (Relief, least absolute shrinkage and selection operator (LASSO) and Random Forest (RF)) and three classification methods, including generalised linear models (GLM), support vector machines (SVM) and RF, were compared for their performance in distinguishing SC and SGCT. Read More

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http://dx.doi.org/10.1007/s00330-018-5730-6DOI Listing
April 2019
4 Reads

Three-Dimensional Volume Imaging to Increase the Accuracy of Surgical Management in a Case of Recurrent Chordoma of the Clivus.

Am J Case Rep 2018 Oct 2;19:1168-1174. Epub 2018 Oct 2.

Department of Orthodontics and Radiology, School of Dentistry, University City of São Paulo (UNICID), São Paulo, SP, Brazil.

BACKGROUND The clivus is a depression in the anterior occipital bone of the skull base, posterior to the dorsum sellae, at the junction with the sphenoid bone. Chordoma is a rare tumor arising from embryonic remnants of the notochord and can be locally aggressive with a tendency to recur. The optimal management of this rare tumor remains controversial. Read More

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http://dx.doi.org/10.12659/AJCR.911592DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6180943PMC
October 2018
16 Reads

Primary sphenoid lymphoma: Focus on imaging.

Tumori 2018 Oct 1:300891618803501. Epub 2018 Oct 1.

1 Department of Medicine, Section of Hematology, University of Verona, Verona, Italy.

Primary lymphoma of the sphenoid is an extremely rare pathology, therefore it is difficult to hypothesize and the imaging characteristics are not well-known. Here we report the imaging features in computed tomography (CT), magnetic resonance imaging (MRI), and positron emission tomography (PET) scan of a 44-year-old patient who presented with severe headache. CT and MRI showed a sphenoid sinus mass that suggested rhinopharyngeal lesion or a chordoma. Read More

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http://journals.sagepub.com/doi/10.1177/0300891618803501
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http://dx.doi.org/10.1177/0300891618803501DOI Listing
October 2018
29 Reads

Endoscopic Endonasal Transclival Approach to Tumors of the Clivus and Anterior Region of the Posterior Cranial Fossa (Results of Surgical Treatment of 136 Patients).

World Neurosurg 2019 Jan 24;121:e246-e261. Epub 2018 Sep 24.

Department of Spine Pathology, N.N. Priorov Central Institute of Traumatology and Orthopedics, Moscow, Russia.

Introduction: With the introduction into the neurosurgical practice of minimally invasive methods using endoscopic techniques, it became possible to effectively remove hard-to-reach tumors, including central tumors of the anterior region of the posterior cranial fossa.

Objective: To analyze the results of surgical treatment of patients with various centrally located tumors of the base of the skull that extend into the anterior region of the posterior cranial fossa using the endoscopic endonasal transclival approach.

Methods: The personal surgical experience of the first author is 136 patients with various tumors (e. Read More

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http://dx.doi.org/10.1016/j.wneu.2018.09.090DOI Listing
January 2019
16 Reads

Surgical Treatment of Sacral Chordoma: En Bloc Resection with Negative Margins is a Determinant of the Long-Term Outcome.

Surg Technol Int 2018 Nov;33:343-348

Department of Orthopedic Surgery, Azienda Ospedaliero-Universitaria Pisana, Pisa, Italy.

Study Design: Retrospective case series.

Objective: To report the outcome of a series of patients with sacral chordoma who were surgically treated at a single center.

Summary: Chordomas are low-grade malignant tumors that arise from remnants of the notochord. Read More

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November 2018
5 Reads

Clival chordoma: long-term clinical outcome in a single center.

Medicine (Baltimore) 2018 Sep;97(36):e12207

Department of Orthopedics, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China.

The treatment of clival chordoma remains highly challenging. This difficulty is enhanced by the very small likelihood of a successful complete surgical resection or nonsurgical treatment of chordoma. Additionally, no effective means of interdisciplinary treatment for chordoma have been identified. Read More

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http://dx.doi.org/10.1097/MD.0000000000012207DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6133562PMC
September 2018
26 Reads

Four-Level Vertebrectomy for En Bloc Resection of a Cervical Chordoma.

World Neurosurg 2018 Oct 27;118:316-323. Epub 2018 Jul 27.

Department of Neurological Surgery, University of Texas Southwestern Medical Center, Dallas, Texas, USA.

Background: Chordomas are locally aggressive tumors that can involve multiple levels of the spine and are difficult to resect. We present our technique for 4-level en bloc cervical spondylectomy for a locally aggressive chordoma.

Case Description: A 37-year-old woman presented with a 6-month history of dysphagia and a large indurated cervical mass. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S18788750183163
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http://dx.doi.org/10.1016/j.wneu.2018.07.153DOI Listing
October 2018
7 Reads
2.420 Impact Factor

Diagnostic accuracy of DW MR imaging in the differentiation of chordomas and chondrosarcomas of the skull base: A 3.0-T MRI study of 105 cases.

Eur J Radiol 2018 Aug 29;105:119-124. Epub 2018 May 29.

Department of Radiooncology, University of Heidelberg, Im Neuenheimer Feld 400, 69120 Heidelberg, Germany; Heidelberg Ion Therapy Center (HIT), Im Neuenheimer Feld 450, 69120 Heidelberg, Germany; German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), Im Neuenheimer Feld 280, 69120 Heidelberg, Germany.

Purpose: To determine the diagnostic accuracy of DW MR imaging with apparent diffusion coefficient (ADC) mapping for the distinction of skull base chordoma from skull base chondrosarcoma.

Patients And Methods: From October 2009 to April 2014, 105 consecutive patients (chordomas (n = 70), and chondrosarcomas (n = 35) who were planned to receive proton or heavy-ion beam therapy underwent DW MR imaging on a 3.0 T. Read More

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http://dx.doi.org/10.1016/j.ejrad.2018.05.026DOI Listing
August 2018
3 Reads

Computed tomography and magnetic resonance imaging features of cervical chordoma.

Oncol Lett 2018 Jul 16;16(1):861-865. Epub 2018 May 16.

Department of Radiology, Affiliated Hospital of Qingdao University, Qingdao, Shandong 266003, P.R. China.

Computed tomography (CT) and magnetic resonance imaging (MRI) scans of 11 patients with histologically proven cervical chordoma were retrospectively evaluated. Imaging features assessed included location, morphology, association with adjacent structures, vertebral destruction, status of cortical bone, periosteal reaction, attenuation and calcification by CT, and signal intensity and enhancement pattern by MRI. Of 7 cases with CT, 6 exhibited lytic-sclerotic bone destruction. Read More

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http://dx.doi.org/10.3892/ol.2018.8721DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6019881PMC

A giant lumbar chordoma: A case report.

Medicine (Baltimore) 2018 Jun;97(25):e11128

Department of Orthopaedics, The First Affiliated Hospital of Nanchang University, Nanchang Shi, Jiangxi Sheng, China.

Rationale: Chordomas are malignant neoplasms derived from incomplete regression of notochordal tissue along the craniococcygeal axis.It is rare for Chordoma arising from the lumbar spine and the traditional long-term prognosis is typically poor.

Patient Concerns: The persistent pain in the left side of the waist about 2 years. Read More

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http://Insights.ovid.com/crossref?an=00005792-201806220-0004
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http://dx.doi.org/10.1097/MD.0000000000011128DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6023704PMC
June 2018
5 Reads

Evidence-Based Optimization of Post-Treatment Surveillance for Skull Base Chordomas Based on Local and Distant Disease Progression.

Oper Neurosurg (Hagerstown) 2019 Jan;16(1):27-36

Department of Neurosurgery, The University of Texas MD Anderson Cancer Center, Houston, Texas.

Background: There are no guidelines regarding post-treatment surveillance specific to skull base chordomas.

Objective: To determine an optimal imaging surveillance schedule to detect both local and distant metastatic skull base chordoma recurrences.

Methods: A retrospective review of 91 patients who underwent treatment for skull base chordoma between 1993 and 2017 was conducted. Read More

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http://dx.doi.org/10.1093/ons/opy073DOI Listing
January 2019
2 Reads

Humeral metastasis of sacrococcygeal chordoma detected by fluorine-18 fluorodeoxyglucose positron emission tomography-computed tomography: A case report.

Radiol Case Rep 2018 Apr 7;13(2):449-452. Epub 2018 Mar 7.

Department of Nuclear Medicine, West China Hospital, Sichuan University, 37 Guoxue Lane, Wuhou District, Chengdu, Sichuan 610000, P.R. China.

Chordomas are rare, slow-growing, locally aggressive bone tumors arising from embryonic remnants of the notochord. Distant metastases most commonly involve the lung, liver, axial skeleton, skin, and lymph nodes. Humeral metastases are extremely rare. Read More

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http://dx.doi.org/10.1016/j.radcr.2018.01.026DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6000026PMC
April 2018
21 Reads

Prognostic Implications of Gadolinium Enhancement of Skull Base Chordomas.

AJNR Am J Neuroradiol 2018 Aug 14;39(8):1509-1514. Epub 2018 Jun 14.

From the Departments of Radiology (E.L., C.D.P.).

Background And Purpose: Skull base chordomas often demonstrate variable MR imaging characteristics, and there has been limited prior research investigating the potential clinical relevance of this variability. The purpose of this retrospective study was to assess the prognostic implications of signal intensity on standard imaging techniques for the biologic behavior of skull base chordomas.

Materials And Methods: Medical records were retrospectively reviewed for 22 patients with pathologically confirmed skull base chordomas. Read More

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http://dx.doi.org/10.3174/ajnr.A5714DOI Listing
August 2018
1 Read

Clival chordoma with drop metastases.

J Radiol Case Rep 2018 Mar 31;12(3):1-9. Epub 2018 Mar 31.

Division of Oncologic Imaging, National Cancer Center Singapore, Singapore, Singapore.

Chordoma is a rare midline malignant tumor arising from embryonic remnants of the primitive notochord. The base of the skull is the second most common site of disease after the sacrococcygeal region. Intracranial chordoma constitutes about 30-35% of chordoma cases. Read More

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http://dx.doi.org/10.3941/jrcr.v12i3.3281DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5965400PMC

Robot-assisted sacral tumor resection: a preliminary study.

BMC Musculoskelet Disord 2018 Jun 6;19(1):186. Epub 2018 Jun 6.

Department of Musculoskeletal Oncology, First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, 510080, China.

Background: Few studies have been done on robot-assisted sacral surgery. This study aims to evaluate the outcomes of seven patients with benign sacral or presacral tumors treated with a robotic surgical system at a single center.

Methods: All patients with benign sacral or presacral tumors who underwent transperitoneal resection (between June 2015 and June 2016) using the da Vinci Si HD robotic surgical system (Intuitive Surgical Inc. Read More

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http://dx.doi.org/10.1186/s12891-018-2084-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5991456PMC
June 2018
24 Reads

[Endoscopic transnasal approach for surgical treatment of skull base clival area chordomas (Report of 2 cases)].

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2018 Feb;32(3):230-232

The case 1 performanced submandibular trauma because of the faint Suddenly. There were no obvious abnormality in physical examination. CT result showed that the tumour located in the lower clivus, and the atlas was infringed. Read More

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http://dx.doi.org/10.13201/j.issn.1001-1781.2018.03.019DOI Listing
February 2018
3 Reads

Evolution of the graded repair of CSF leaks and skull base defects in endonasal endoscopic tumor surgery: trends in repair failure and meningitis rates in 509 patients.

J Neurosurg 2018 05;130(3):861-875

Pacific Pituitary Disorders Center, John Wayne Cancer Institute, Providence Saint John's Health Center, Santa Monica, California.

Objective: The authors previously described a graded approach to skull base repair following endonasal microscopic or endoscope-assisted tumor surgery. In this paper they review their experience with skull base reconstruction in the endoscopic era.

Methods: A retrospective review of a single-institution endonasal endoscopic patient database (April 2010–April 2017) was undertaken. Read More

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http://thejns.org/doi/10.3171/2017.11.JNS172141
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http://dx.doi.org/10.3171/2017.11.JNS172141DOI Listing
May 2018
14 Reads

Role of the Apparent Diffusion Coefficient as a Predictor of Tumor Progression in Patients with Chordoma.

AJNR Am J Neuroradiol 2018 Jul 3;39(7):1316-1321. Epub 2018 May 3.

Asahikawa Medical University (T.S., S.I., A.O., M.T., K.T.), Asahikawa, Hokkaido, Japan.

Background And Purpose: Diffusion-weighted imaging may aid in distinguishing aggressive chordoma from nonaggressive chordoma. This study explores the prognostic role of the apparent diffusion coefficient in chordomas.

Materials And Methods: Sixteen patients with residual or recurrent chordoma were divided postoperatively into those with an aggressive tumor, defined as a growing tumor having a doubling time of <1 year, and those with a nonaggressive tumor on follow-up MR images. Read More

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http://dx.doi.org/10.3174/ajnr.A5664DOI Listing
July 2018
4 Reads

Pituitary fossa chondrosarcoma: An unusual cause of a sellar suprasellar mass masquerading as pituitary adenoma.

Surg Neurol Int 2018 9;9:76. Epub 2018 Apr 9.

Department of Neuro-Surgery, Govind Ballav Pant Institute of Postgraduate Medical Education and Research (GIPMER), New Delhi, India.

Background: Chondrosarcoma is a mesenchymal malignant tumor composed of tumor cells producing cartilage. It is more commonly found in older age group and usually affects the axial skeleton. Intracranial chondrosarcoma is extremely rare, and chondrosarcoma arising from the sellar region are even rarer with only a few cases described in the literature. Read More

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http://dx.doi.org/10.4103/sni.sni_455_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5909095PMC
April 2018
20 Reads

Initial Experience with Intraoperative Phosphorous-32 Brachytherapy During Resection of Malignant Spinal Tumors.

World Neurosurg 2018 07 24;115:e785-e793. Epub 2018 Apr 24.

Department of Neurological Surgery, University of California, San Francisco, San Francisco, California, USA. Electronic address:

Introduction: Brachytherapy is a major adjuvant modality for neoplasms, but few have trialed its use for spinal tumors. This study examines perioperative and oncologic outcomes of patients with malignant spinal tumors who underwent resection with intraoperative phosphorous-32 (P32) brachytherapy.

Methods: Consecutive adult patients who underwent P32 brachytherapy during malignant spinal tumor resection were retrospectively identified from 2014 to 2015. Read More

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http://dx.doi.org/10.1016/j.wneu.2018.04.105DOI Listing
July 2018
7 Reads

A cavernous sinus lesion clinically responsive to steroids.

J Clin Neurosci 2018 Jul 21;53:239-240. Epub 2018 Apr 21.

Mayo Clinic, 200 1st Street SW, Rochester, MN 55905, USA. Electronic address:

Tolosa Hunt syndrome (THS) is characterized by painful ophthalmoplegia secondary to idiopathic granulomatous inflammation of the cavernous sinus. The characteristic finding on MRI is an enhancing T1 isointense and T2 hypo- or hyperintense cavernous sinus mass lesion, which may result in focal narrowing of the ipsilateral internal carotid artery. Although the incidence is quite rare, it is a common diagnostic consideration in cases that present with multiple cranial neuropathies. Read More

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http://dx.doi.org/10.1016/j.jocn.2018.04.020DOI Listing
July 2018
19 Reads

Clival Chordoma: Case Report and Review of Recent Developments in Surgical and Adjuvant Treatments.

Pol J Radiol 2017 17;82:670-675. Epub 2017 Nov 17.

Department of Internal Medicine, Sinai-Grace Hospital/Detroit Medical Center, Detroit, MI, U.S.A.

Chordomas are rare tumors that can develop anywhere along the craniospinal axis. These tumors present challenges with respect to diagnosis and treatment due to a high rate of recurrence, even after multiple surgeries, and the propensity to involve any region within the craniospinal axis. New developments in radiation therapy have improved recurrence-free survival in patients with chordomas. Read More

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http://dx.doi.org/10.12659/PJR.902008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5894024PMC
November 2017
2 Reads

State-of-the-Art Imaging in Human Chordoma of the Skull Base.

Curr Radiol Rep 2018 3;6(5):16. Epub 2018 Apr 3.

1Department of Radiology, Maastricht University Medical Center, P. Debyelaan 25, 6229 HX Maastricht, The Netherlands.

Purpose Of Review: Chordoma are rare tumours of the axial skeleton which occur most often at the base of the skull and in the sacrum. Although chordoma are generally slow-growing lesions, the recurrence rate is high and the location makes it often difficult to treat. Both computed tomography (CT) and magnetic resonance imaging (MRI) are crucial in the initial diagnosis, treatment planning and post-treatment follow-up. Read More

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http://dx.doi.org/10.1007/s40134-018-0275-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5882758PMC
April 2018
4 Reads

Poorly Differentiated Chordomas Showing Loss of INI1/SMARCB1: A Report of 2 Rare Cases With Diagnostic Implications.

Int J Surg Pathol 2018 Oct 6;26(7):637-643. Epub 2018 Apr 6.

2 Hacettepe University, Ankara, Turkey.

Poorly differentiated chordomas are rare musculoskeletal tumors. Case 1. A 42-year-old lady presented with quadriparesis of 2 months' duration. Read More

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http://dx.doi.org/10.1177/1066896918768043DOI Listing
October 2018
6 Reads

The importance of preoperative tissue sampling for mobile spine chordomas: literature review and report of two cases.

Spinal Cord Ser Cases 2018 13;4:21. Epub 2018 Mar 13.

1Division of Neurosurgery, Department of Surgery, Sunnybrook Health Sciences Centre, University of Toronto, ON, Canada.

Introduction: Pre-operative biopsy and diagnosis of chordomas of the mobile spine is indicated as en bloc resections improve outcomes. This review of the management of mobile spine chordomas includes two cases of unexpected mobile spine chordomas where a preoperative tissue diagnosis was decided against and may have altered surgical decision-making.

Case Presentation: Two lumbar spine chordomas thought to be metastatic and primary bony lesions preoperatively were not biopsied before surgery and eventual pathology revealed chordoma. Read More

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http://dx.doi.org/10.1038/s41394-018-0061-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5849678PMC
March 2018
4 Reads

What Is the Effect of High-dose Radiation on Bone in Patients With Sacral Chordoma? A CT Study.

Clin Orthop Relat Res 2018 03;476(3):520-528

O. van Wulfften Palthe, Massachusetts General Hospital, Boston, MA, USA K.-W. Jee, Y.-L. E. Chen, Department of Radiation Oncology, Massachusetts General Hospital-Harvard Medical School, Boston, MA, USA J. A. M. Bramer, Department of Orthopaedic Surgery, Academic Medical Center, Amsterdam, Amsterdam, The Netherlands F. J. Hornicek, Harvard Medical School, Orthopaedic Oncology Service, Massachusetts General Hospital-Harvard Medical School, Boston, MA, USA J. H. Schwab, Department of Orthopaedic Surgery, Orthopaedic Oncology Service, Spine Surgery Service, Massachusetts General Hospital-Harvard Medical School, Boston, MA, USA.

Background: Effects of high-dose radiation using protons and photons on bone are relatively unexplored, but high rates of insufficiency fractures are reported, and the causes of this are incompletely understood. Imaging studies with pre- and postradiation scans can help one understand the effect of radiation on bone.

Questions/purposes: The purpose of this study was to assess the effects of high-dose radiation on the trabecular density of bone in the sacrum using CT-derived Hounsfield units (HU). Read More

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http://dx.doi.org/10.1007/s11999.0000000000000063DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6260039PMC
March 2018
3 Reads

Chordomas of the Skull Base, Mobile Spine, and Sacrum: An Epidemiologic Investigation of Presentation, Treatment, and Survival.

World Neurosurg 2018 May 25;113:e618-e627. Epub 2018 Feb 25.

Department of Neurosurgery, Memorial Sloan-Kettering Cancer Center, New York, New York, USA; Department of Neurological Surgery, Weill Cornell Medical College, New York, New York, USA.

Background: Chordomas are rare primary bone tumors that arise from the axial skeleton. Our objective was to analyze trends in radiation and surgery over time and determine location-based survival predictors for chordomas of the skull base, mobile spine, and sacrum.

Methods: A retrospective cohort study of the SEER (Surveillance Epidemiology and End Results) database from 1973 to 2013 was conducted. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S18788750183038
Publisher Site
http://dx.doi.org/10.1016/j.wneu.2018.02.109DOI Listing
May 2018
8 Reads

Cardiac Metastasis from Clivus Chordoma.

World Neurosurg 2018 May 14;113:103-107. Epub 2018 Feb 14.

Department of Neurosurgery, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.

Background: Chordomas are rare tumors showing locally aggressive nature and high rates of local recurrences. Distant metastases are infrequently reported and cardiac metastases are extremely rare.

Case Description: A 32-year-old woman had been diagnosed with a large chordoma involving the clivus. Read More

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http://dx.doi.org/10.1016/j.wneu.2018.02.041DOI Listing
May 2018
2 Reads

[Chordoma cutis, an unusual clinical presentation of a rare neoplasm: Chordoma].

Ann Pathol 2018 Apr 12;38(2):126-130. Epub 2018 Feb 12.

Service d'anatomie pathologique et neuropathologie, CHU Timone, 264, rue Saint-Pierre, 13005 Marseille cedex 5, France.

Chordoma cutis represents an unusual clinical presentation of a rare neoplasm. The involvement of skin or sub-cutaneous soft tissues can be the consequence of local infiltration or metastasis; the latter may occur several years following the initial diagnosis of chordoma and therefore, may pose a diagnosis challenge when the clinical history of the patient is unknown. The clinical forms, morphology, immuno-histochemical profile and the main differential diagnoses of chordoma cutis are presented here through an anatomoclinical case. Read More

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http://dx.doi.org/10.1016/j.annpat.2018.01.004DOI Listing
April 2018
4 Reads

Differentiating skull base chordomas and invasive pituitary adenomas with conventional MRI.

Acta Radiol 2018 Nov 15;59(11):1358-1364. Epub 2018 Feb 15.

Department of Magnetic Resonance, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, PR China.

Background It is difficult to distinguish between invasive pituitary adenomas (IPAs) and skull base chordomas based on tumor location and clinical manifestations. Purpose To investigate the value of the apparent diffusion coefficient (ADC), T2-weighted (T2W) imaging, and dynamic contrast enhancement (DCE) in differentiating skull base chordomas and IPAs. Material and Methods Data for 21 patients with skull base chordomas and 27 patients with IPAs involving the paranasal sinus were retrospectively reviewed, and all diagnoses were pathologically confirmed. Read More

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http://dx.doi.org/10.1177/0284185118757576DOI Listing
November 2018
7 Reads

The Sellar Tumor: Metastasis or Chordoma?

J Craniofac Surg 2018 May;29(3):e259-e261

Department of Neurosurgery, Shanghai Tenth People's Hospital, Tongji University School of Medicine.

Chordomas are uncommon, locally invasive chordate tumors, which are mostly observed in the axial skeleton. Numerous papers have described similar patients around different anatomic locations; however, rare document previously reported that intracranial chordoma was associated with clear cell renal cell carcinoma (ccRCC). The authors report a 51-year-old male patient with a history of right radical nephrectomy for ccRCC presented to us with progressive blurred vision. Read More

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http://dx.doi.org/10.1097/SCS.0000000000004284DOI Listing
May 2018
3 Reads
0.680 Impact Factor

Diagnosis of benign notochordal cell tumor of the spine: is a biopsy necessary?

Clin Case Rep 2018 01 24;6(1):63-67. Epub 2017 Nov 24.

Department of Orthopaedic Surgery Faculty of Medicine Tohoku Medical and Pharmaceutical University Sendai Japan.

Benign notochordal cell tumor is a benign intraosseous lesion, demonstrates characteristic imaging features. The lesion demonstrates low-signal intensity in T1-weighted images, high-signal intensity in T2-weighted images, and no enhancement with contrast medium in MRI and slight osteosclerosis in CT. If typical imaging findings are identified, biopsy is not necessary. Read More

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http://dx.doi.org/10.1002/ccr3.1287DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5771900PMC
January 2018
2 Reads