2,204 results match your criteria Imaging in Chiari I Malformation


Severe Cerebellar Degeneration and Chiari I Malformation - Speculative pathophysiology based on a systematic review.

Rev Assoc Med Bras (1992) 2020 Mar;66(3):375-379

. Professor de Neurocirurgia - Universidade de Campinas (UNICAMP), Campinas-SP Brasil.

Background: Symptomatic Chiari Type I Malformation (CM) is treated with posterior fossa decompression with or without duroplasty. We have noticed some cases with concomitant severe cerebellar ataxia due to cerebellar atrophy. The aim of this study is to review the literature of CM associated with severe cerebellar atrophy and discuss its potential physiopathology. Read More

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http://dx.doi.org/10.1590/1806-9282.66.3.375DOI Listing

Pathological and Incidental Findings in 403 Taiwanese Girls With Central Precocious Puberty at Initial Diagnosis.

Front Endocrinol (Lausanne) 2020 5;11:256. Epub 2020 May 5.

Department of Pediatrics, Chang Gung Memorial Hospital, Taoyuan, Taiwan.

Whether girls with central precocious puberty (CPP) should undergo routine brain magnetic resonance imaging (MRI) to identify potential intracranial pathologies is controversial. To evaluate the brain MRI results of girls with CPP and identify the clinical and endocrine predictors of brain abnormalities. This retrospective study obtained data from pediatric endocrine clinics at Chang Gung Children's Hospital. Read More

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http://dx.doi.org/10.3389/fendo.2020.00256DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7214687PMC

The impact of depression on surgical outcome in Chiari malformation type I: an assessment based on the Chicago Chiari Outcome Scale.

J Neurosurg Spine 2020 Apr 24:1-8. Epub 2020 Apr 24.

1Department of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore.

Objective: The effect of depression on outcomes in Chiari malformation type I (CM-1) is unclear. The authors sought to determine whether depression affects outcome in a surgical cohort of CM-1 patients by using a validated outcome assessment tool, the Chicago Chiari Outcome Scale (CCOS).

Methods: The authors performed a retrospective analysis of a prospectively maintained database of 149 adult CM-1 patients undergoing suboccipital decompression with duraplasty and cranioplasty. Read More

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http://dx.doi.org/10.3171/2020.2.SPINE2069DOI Listing

Occipital Condyle Screw Placement in Patients with Chiari Malformation: A Radiographic Feasibility Analysis and Cadaveric Demonstration.

World Neurosurg 2020 Apr;136:470-478

Department of Neurological Surgery, Weill Cornell Brain and Spine Center, New York-Presbyterian Hospital, Weill Cornell Medicine, New York, New York, USA. Electronic address:

Objective: Patients who undergo decompression surgery for Chiari malformation frequently require occipitocervical fixation. This is typically performed with occipital plates, which may cause intracranial injuries due to multiple fixation points. We undertook this study to assess the feasibility of occipital condyle (OC) screw placement as an alternative method of occipitocervical fixation in this patient population. Read More

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http://dx.doi.org/10.1016/j.wneu.2020.01.150DOI Listing

Neuroanatomic Correlates for the Neuropsychological Manifestations of Chiari Malformation Type I.

World Neurosurg 2020 Apr;136:462-469

Department of Neurological Surgery, Weill Cornell Medicine, New York, New York, USA. Electronic address:

Chiari malformation comprises a spectrum of congenital malformations characterized by a herniation of the cerebellar tonsils below the foramen magnum. Chiari malformation type I (CM-I) is the most prevalent subtype seen in clinical practice. This condition variably compresses the cerebellum and medulla-spinal cord junction secondary to malformation of the posterior fossa. Read More

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http://dx.doi.org/10.1016/j.wneu.2020.01.149DOI Listing

Persistent Syringomyelia After Posterior Fossa Decompression for Chiari Malformation.

World Neurosurg 2020 Apr;136:454-461.e1

Department of Neurosurgery, Weill Cornell Medicine, New York, New York, USA. Electronic address:

Background: Chiari malformation (CM) is often comorbid with syringomyelia. The treatment of CM via posterior fossa decompression (PFD) may not improve syringomyelia in up to 40% of patients, based on historical cohorts. Management of these patients is problematic, as both reoperation and syrinx shunting have high failure rates in the long term. Read More

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http://dx.doi.org/10.1016/j.wneu.2020.01.148DOI Listing

Ventrolateral Tonsillar Position Defines Novel Chiari 0.5 Classification.

World Neurosurg 2020 Apr;136:444-453

Department of Neurological Surgery, New York-Presbyterian Hospital/Weill Cornell Medical Center, New York, New York, USA. Electronic address:

Background: Cervicomedullary compression in young children has been described in the context of Chiari type 1 malformation, with symptoms associated with the extent of tonsillar herniation below McRae line. Historically, Chiari type 1 malformation has been defined by tonsillar herniation of at least 5 mm. However, in certain populations, including very young children, Chiari symptoms may be present without this finding. Read More

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http://dx.doi.org/10.1016/j.wneu.2020.01.147DOI Listing

Cerebrospinal fluid area and syringogenesis in Chiari malformation type I.

J Neurosurg 2020 Feb 21:1-6. Epub 2020 Feb 21.

1Department of Neurological Surgery, University of Virginia Health System, Charlottesville, Virginia; and.

Objective: Syringogenesis in Chiari malformation type I (CM-I) is thought to occur secondary to impaction of the cerebellar tonsils within the foramen magnum (FM). However, the correlation between the CSF area and syringogenesis has yet to be elucidated. The authors sought to determine whether the diminution in subarachnoid space is associated with syringogenesis. Read More

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http://dx.doi.org/10.3171/2019.11.JNS191439DOI Listing
February 2020

Arnold-Chiari malformation type I and the posterior dislocation of the odontoid process aggravate prolonged weaning in a patient with severe viral pneumonia: a case report.

BMC Pulm Med 2020 Feb 11;20(1):37. Epub 2020 Feb 11.

Department of Intensive Care, The First Hospital of China Medical University, Nanjing Bei Street 155, Shenyang, 110001, Liaoning Province, People's Republic of China.

Background: Prolonged and difficult weaning is associated with higher rates of complications and mortality. Therefore, it is important to identify the associated factors.

Case Presentation: We describe our experience with a 37-year-old man diagnosed with severe viral pneumonia (influenza A). Read More

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http://dx.doi.org/10.1186/s12890-020-1078-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7014774PMC
February 2020

CSF goes astray no matter what is in the way: occipital intradiploic pseudomeningocele and de novo syringomyelia following foramen magnum decompression for Chiari I malformation in a pediatric patient.

J Neurosurg Pediatr 2020 Feb 7:1-6. Epub 2020 Feb 7.

1Department of Pediatric Neurosurgery, Oxford University Hospitals NHS Foundation Trust, John Radcliffe Hospital, Oxford, United Kingdom; and.

Nontraumatic intradiploic pseudomeningoceles and de novo syringomyelia formation are very rare entities. The authors have previously reported the case of a 4-year-old girl who underwent foramen magnum decompression without dural closure for Chiari I malformation. Three years after the operation an intradiploic pseudomeningocele was documented, but the patient was lost to follow-up without undergoing revision surgery. Read More

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http://dx.doi.org/10.3171/2019.12.PEDS19427DOI Listing
February 2020

"Two-Birds-One-Stone" Approach for Treating an Infant with Chiari I Malformation and Hydrocephalus: Is Cerebrospinal Fluid Diversion as Sole Treatment Enough?

World Neurosurg 2020 05 3;137:174-177. Epub 2020 Feb 3.

Department of Neurosurgery, Ochsner Clinic Foundation, New Orleans, Louisiana, USA.

Background: Chiari I malformation (CIM) is a disorder characterized by caudal displacement of the cerebellar tonsils below the foramen magnum. It is often associated with syringomyelia and occasionally with hydrocephalus. CIM is commonly treated by posterior fossa decompression with or without removal of the posterior arch of C1 and duraplasty, but the treatment for infants with symptomatic CIM is not well established. Read More

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http://dx.doi.org/10.1016/j.wneu.2020.01.188DOI Listing
May 2020
2.417 Impact Factor

Postnatal Intracranial Findings Following Fetal Repair of Spinal Dysraphisms.

J Comput Assist Tomogr 2020 Jan/Feb;44(1):65-69

From the Division of Neuroradiology, Department of Diagnostic and Interventional Imaging.

Objective: Our objective is to document the imaging appearance in the intracranial compartment at the time of the infants' first postnatal brain MR imaging after fetal repair for spinal dysraphisms.

Methods: Twenty-nine patients were evaluated on fetal and postnatal magnetic resonance imaging for a series of features of Chiari II malformation.

Results: Of the 29 infants, 55% had resolution of tonsillar ectopia, and 62% showed a dorsal outpouching of the near the foramen magnum on postnatal magnetic resonance imaging. Read More

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http://dx.doi.org/10.1097/RCT.0000000000000962DOI Listing
January 2020

Acute traumatic presentation of Chiari I malformation with central cord syndrome and presyrinx in an infant.

Surg Neurol Int 2019 27;10:253. Epub 2019 Dec 27.

Department of Neurological Surgery, University of Washington, WA, United States.

Background: Chiari I malformation (CM-I) typically presents in late childhood and early adulthood. Often these lesions are asymptomatic and discovered incidentally. Patients typically present with tussive headaches and focal neurological findings, especially when associated with syringomyelia. Read More

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http://dx.doi.org/10.25259/SNI_256_2019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6935965PMC
December 2019

Chiari Malformation and Syringomyelia Associated with Hirayama Disease.

World Neurosurg 2020 Mar 24;135:241-244. Epub 2019 Dec 24.

Department of Neurosurgery, King Edward Memorial Hospital and Seth Gordhandas Sunderdas Medical College, Mumbai, India.

Background: To the best of our knowledge, the presence of Chiari formation and Hirayama disease in the same patient has not been previously reported. On the basis of the presented case, we have attempted to identify the common pathogenesis of both of these clinical entities.

Case Description: We have reported a case of a 23-year-old male patient who had presented with complaints of pain in the nape of neck and shoulders of 9 months' duration, weakness and stiffness in all 4 limbs, and wasting and weakness of muscles of both hands of 6 months' duration. Read More

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http://dx.doi.org/10.1016/j.wneu.2019.12.101DOI Listing

Spinal cord infarction with resultant paraplegia after Chiari I decompression: case report.

J Neurosurg Spine 2019 Dec 20:1-7. Epub 2019 Dec 20.

Departments of1Neurosurgery and.

Paraplegia after posterior fossa surgery is a rare and devastating complication. The authors reviewed a case of paraplegia following Chiari decompression and surveyed the literature to identify strategies to reduce the occurrence of such events.An obese 44-year-old woman had progressive left arm pain, weakness, and numbness and tussive headaches. Read More

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http://dx.doi.org/10.3171/2019.10.SPINE19921DOI Listing
December 2019

Neurosurgical Management of Lateral Meningocele Syndrome: A Clinical Update for the Pediatric Neurosurgeon.

Pediatr Neurosurg 2020 13;55(1):2-11. Epub 2019 Dec 13.

Carilion Clinic, Section of Neurosurgery, Roanoke, Virginia, USA.

Background: Lateral meningocele syndrome (LMS) is an exceedingly rare connective tissue disease with phenotypic anomalies similar to those seen in Marfan syndrome, Ehler-Danlos syndrome, and Loeys-Dietz syndrome. However, this syndrome is invariably associated with the presence of multiple lateral thoracolumbar spinal meningoceles: a distinct point of phenotypic divergence from other connective tissue disorders. The etiopathogenesis of this syndrome has recently been linked to truncating mutations within exon 33 of NOTCH3. Read More

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http://dx.doi.org/10.1159/000504060DOI Listing
December 2019

The Fetal Posterior Fossa on Prenatal Ultrasound Imaging: Normal Longitudinal Development and Posterior Fossa Anomalies.

Ultraschall Med 2019 Dec 3;40(6):692-721. Epub 2019 Dec 3.

Institute of Human Genetics, Medical University Graz, Austria.

Fetal neurosonography and the assessment of the posterior fossa have gained in importance during the last 2 decades primarily due to the development of high-resolution ultrasound probes and the introduction of 3 D sonography. The anatomical development of the posterior fossa can be visualized well with the newest ultrasound technologies. This allows better knowledge of the anatomical structures and helps with understanding of the development of malformations of the posterior fossa. Read More

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http://dx.doi.org/10.1055/a-1015-0157DOI Listing
December 2019

Electroconvulsive Therapy With Chiari Malformation.

J ECT 2019 12;35(4):e58-e59

University of Minnesota Medical School Minneapolis, MN University of Minnesota Minneapolis, MN Regions Hospital St Paul, MN University of Louisville School of Medicine Louisville, KY.

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http://dx.doi.org/10.1097/YCT.0000000000000631DOI Listing
December 2019

Comparison of Radiological Features and Clinical Characteristics in Scoliosis Patients With Chiari I Malformation and Idiopathic Syringomyelia: A Matched Study.

Spine (Phila Pa 1976) 2019 Dec;44(23):1653-1660

Department of Orthopedics, Peking Union Medical College Hospital and Graduate School of Peking Union Medical College, Peking Union Medical College, Chinese Academy of Medical Science, Beijing, China.

Study Design: Retrospective study.

Objective: To compare syrinx characteristics, scoliotic parameters, and neurological deficits between Chiari I malformation (CIM) and idiopathic syringomyelia (IS) in the scoliotic population.

Summary Of Background Data: CIM and IS are common in neuromuscular scoliosis patients; however, differences in syrinx characteristics, scoliotic parameters, and neurological deficits between CIM and IS are unclear. Read More

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http://dx.doi.org/10.1097/BRS.0000000000003140DOI Listing
December 2019
3 Reads
2.297 Impact Factor

Presyrinx Associated with Post-Traumatic Hydrocephalus Successfully Treated by Ventriculoperitoneal Shunt.

Korean J Neurotrauma 2019 Oct 11;15(2):187-191. Epub 2019 Sep 11.

Department of Neurosurgery, Soonchunhyang University Bucheon Hospital, Bucheon, Korea.

Presyrinx consists of reversible spinal cord swelling without frank cavitation, as observed on T2 weighted magnetic resonance imaging (MRI). The condition may evolve into syringomyelia, but timely surgical interventions have achieved meaningful results. Here, we report the case of a 27-year-old woman who presented with headache, dizziness, and diplopia 2 months after suffering a mild head trauma. Read More

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http://dx.doi.org/10.13004/kjnt.2019.15.e22DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6826087PMC
October 2019

Cerebrospinal Fluid Flowmetry in Pediatric Patients with Chiari Malformation I with Surgical Implications.

World Neurosurg 2020 Mar 5;135:e83-e86. Epub 2019 Nov 5.

Department of Neurosurgery, Bangur Institute of Neurosciences, Institute of Post Graduate Medical Education and Research, Kolkata, India.

Background: Chiari malformations include a large spectrum of anomalies of hindbrain formation that appear at different stages of development of the central nervous system. Chiari described these malformations as congenital anomalies of the hindbrain characterized by downward elongation of the brain stem and cerebellum into the cervical portion of spinal cord. Much research regarding Chiari malformation I (CMI) has focused on the cerebrospinal fluid (CSF) dynamics rather than the anatomic relationships of the tonsils and brainstem. Read More

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http://dx.doi.org/10.1016/j.wneu.2019.10.184DOI Listing

Systematic review and meta-analysis of imaging characteristics in Chiari I malformation: does anything really matter?

Childs Nerv Syst 2020 Mar 7;36(3):525-534. Epub 2019 Nov 7.

Division of Pediatric Neurosurgery, Children's of Alabama-University of Alabama at Birmingham, Lowder Bldg., Suite 400, 1600 7th Ave. S, Birmingham, AL, 35233, USA.

Purpose: Previous studies have attempted to evaluate the utility of preoperative magnetic resonance imaging (MRI) parameters in predicting outcomes in Chiari I malformation. We performed a systematic review and meta-analysis to determine what preoperative imaging features (if any) predict (1) presence of preoperative symptoms or associated findings, (2) need for surgical decompression, or (3) improvement after surgical decompression.

Methods: All publications through June 2018 on PubMed, Embase, and Cochrane Library databases were searched using the keywords "Chiari I malformation" AND "decompression" OR "imaging. Read More

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http://dx.doi.org/10.1007/s00381-019-04398-4DOI Listing

Chiari malformation and syringomyelia.

J Neurosurg Spine 2019 Nov;31(5):619-628

Chiari malformation was first described over a century ago, and consists of posterior fossa anomalies that generally share the feature of cerebellar tonsillar descent through the foramen magnum. Our understanding of this disorder was initially based on autopsy studies, and has been greatly enhanced by the advent of MRI. The surgical management of Chiari anomalies has also evolved in a parallel fashion. Read More

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http://dx.doi.org/10.3171/2019.7.SPINE181139DOI Listing
November 2019
1 Read

Intraoperative Phase Contrast MRI Analysis of Cerebrospinal Fluid Velocities During Posterior Fossa Decompression for Chiari I Malformation.

J Magn Reson Imaging 2020 May 30;51(5):1463-1470. Epub 2019 Oct 30.

Department of Neurosurgery, University of Michigan, Ann Arbor, Michigan, USA.

Background: Cerebrospinal fluid (CSF) velocity at the craniovertebral junction (CVJ) is known to be altered in patients with Chiari I malformation (CMI), and normalization of CSF velocities is associated with symptom resolution. However, preoperative and intraoperative prediction methods have thus far failed to identify patients in whom CSF velocities can be normalized with posterior fossa decompression (PFD) without duraplasty. Phase contrast MRI (PC-MRI) may assist not only in diagnosis of CMI but also in guiding the intraoperative decision to perform duraplasty during PFD. Read More

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http://dx.doi.org/10.1002/jmri.26953DOI Listing

Precocious puberty and Chiari I malformation with syrinx: a case report of an unusual presentation of Costello syndrome.

Int J Pediatr Endocrinol 2019 22;2019. Epub 2019 Oct 22.

2Division of Pediatric Endocrinology & Diabetes, Children's Hospital at Montefiore, Albert Einstein College of Medicine, 3415 Bainbridge Ave, Bronx, NY 10467 USA.

Background: Costello syndrome (CS) is a rare RASopathy causing developmental delays, short stature and classically, delayed puberty. We present a patient with CS and central precocious puberty (CPP).

Case Presentation: A female patient with CS presented at 6 years 10 months of age with breast development. Read More

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http://dx.doi.org/10.1186/s13633-019-0067-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6805387PMC
October 2019

Incidence of Asymptomatic Chiari Malformation

Ir Med J 2019 08 1;112(7):972. Epub 2019 Aug 1.

Department of Radiology, Tallaght Hospital, Dublin

Aim The aim of this study is to define the incidence of asymptomatic Chiari malformation in an Irish population. Methods MRIs performed over 24 months were analysed. Exclusion criteria include: space occupying lesion, hydrocephalus, Chiari symptoms and inadequate views. Read More

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Reversible Progressive Multiple Cranial Nerve Paresis in the Isolated Fourth Ventricle following Placement of Fourth Ventricle Shunt: Case Report and Review of the Literature.

Pediatr Neurosurg 2019 9;54(6):405-410. Epub 2019 Oct 9.

Division of Neurosurgery, Department of Surgery, University of Texas Medical Branch at Galveston, Galveston, Texas, USA,

Background/aims: Multiple lower cranial nerve paresis occurring after placement of a fourth ventricle shunt for an isolated fourth ventricle is an uncommon complication in the postoperative period. Of the various etiologies, direct brain stem injury by the catheter and rapid decompression of the fourth ventricle by the shunt causing traction on the cranial nerves have been reported in the literature.

Methods: We report the case of a 9-year-old girl with an isolated fourth ventricle who developed bilateral facial and multiple lower cranial nerve paresis with bilateral internuclear ophthalmoplegia a month after placement of a ventriculoperitoneal shunt. Read More

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http://dx.doi.org/10.1159/000503088DOI Listing

«A case of a pharmacoresistant tachyarrhythmia associated with Arnold-Chiari malformation».

Br J Neurosurg 2019 Dec 26;33(6):671-672. Epub 2019 Sep 26.

Republican Cardiology Center Ufa, Ufa, Russian.

Arnold-Chiari malformation is a group of congenital malformations of the hindbrain. Common symptoms include cephalgia, vestibular, cerebral and cochlear disorders We present a case of pharmacoresistant tachyarrhythmia associated with Arnold-Chiari malformation. A 49-year-old female patient had an Arnold-Chiari malformation (ACM), syringomyelia, a retrocerebellar cyst and a 6 year history of tachyarrhythmia. Read More

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http://dx.doi.org/10.1080/02688697.2019.1668540DOI Listing
December 2019
1 Read

Using machine learning to understand neuromorphological change and image-based biomarker identification in Cavalier King Charles Spaniels with Chiari-like malformation-associated pain and syringomyelia.

J Vet Intern Med 2019 Nov 24;33(6):2665-2674. Epub 2019 Sep 24.

CVSSP, Centre for Vision, Speech and Signal Processing, University of Surrey, Guildford, United Kingdom.

Background: Chiari-like malformation (CM) is a complex malformation of the skull and cranial cervical vertebrae that potentially results in pain and secondary syringomyelia (SM). Chiari-like malformation-associated pain (CM-P) can be challenging to diagnose. We propose a machine learning approach to characterize morphological changes in dogs that may or may not be apparent to human observers. Read More

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http://dx.doi.org/10.1111/jvim.15621DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6872629PMC
November 2019
3 Reads

Determination of Normal Values of the Basal Angle in the Era of Magnetic Resonance Imaging.

World Neurosurg 2019 Dec 18;132:363-367. Epub 2019 Sep 18.

Department of Neurosurgery, Hospital do Servidor Público do Estado de São Paulo, São Paulo, Brazil. Electronic address:

Background: The flexion of the skull base (basal angle [BA]) is the inclination between the anterior fossae and the basilar ramp of the occipital and sphenoid bones. An increased BA, termed platybasia, is usually associated with basilar invagination. BA reference values in the magnetic resonance imaging (MRI) era and the diagnosis of platybasia are of clinical importance. Read More

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http://dx.doi.org/10.1016/j.wneu.2019.09.056DOI Listing
December 2019
1 Read

Acquired Chiari I malformation due to lumboperitoneal shunt: A case report and review of literature.

Surg Neurol Int 2019 10;10:78. Epub 2019 May 10.

Department of Neurosurgery, Burns and Trauma Center, Ben Arous, Tunis, Tunisia.

Background: The Type I malformations are supposed to be the result of mesodermal defects that create a congenitally small posterior fossa. However, Chiari malformation could be also "iatrogenic" and then called "acquired" Chiari I malformation. In this study, the authors report the clinical feature of a patient who developed a Chiari I malformation after lumboperitoneal shunt. Read More

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http://dx.doi.org/10.25259/SNI-234-2019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6744799PMC
May 2019
3 Reads

Fourth Ventricle Enlargement in Chiari Malformation Type I.

World Neurosurg 2020 Jan 9;133:e259-e266. Epub 2019 Sep 9.

Departments of Neurosurgery, University of Iowa Hospitals and Clinics, University of Iowa Stead Family Children's Hospital, Iowa City, Iowa, USA; Pappajohn Biomedical Institute, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA; Iowa Neuroscience Institute, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA. Electronic address:

Objective: How Chiari malformation type I (CM-I) affects posterior fossa brain structures and produces various symptoms remains unclear. The fourth ventricle is surrounded by critical structures required for normal function. The foramen of Magendie can be obstructed in CM-I; therefore, fourth ventricle changes may occur. Read More

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http://dx.doi.org/10.1016/j.wneu.2019.08.230DOI Listing
January 2020
1 Read

The Clinical Utility of Flexion-extension Cervical Spine MRI in 22q11.2 Deletion Syndrome.

J Pediatr Orthop 2019 Oct;39(9):e674-e679

The Children's Hospital of Philadelphia, Philadelphia, PA.

Background: Our goal is to correlate the findings on flexion and extension radiographs with dynamic magnetic resonance imaging (MRI), and the clinical history, in a nonrandomly selected cohort of patients with 22q11.2 deletion syndrome (22q).

Methods: All patients with the 22q who had a dynamic MRI from January 2004 to March 2015 were included. Read More

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http://Insights.ovid.com/crossref?an=01241398-201910000-0000
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http://dx.doi.org/10.1097/BPO.0000000000000994DOI Listing
October 2019
2 Reads

Effects of growth hormone therapy in pediatric patients with growth hormone deficiency and Chiari I malformation: a retrospective study.

Childs Nerv Syst 2020 Apr 9;36(4):835-839. Epub 2019 Sep 9.

Division of Neurosurgery, Arkansas Children's Hospital, Little Rock, AR, USA.

Purpose: The safety and efficacy of growth hormone replacement therapy (GHRT) on pediatric patients with growth hormone deficiency (GHD) and Chiari I malformation (CIM) are not well investigated within the current body of literature. With no clear indication of the effects of GHRT on CIM disease progression, we sought to determine the effect of GHRT on tonsillar herniation and progression of CIM symptomatology.

Methods: From a previously established database of 465 patients with radiologically confirmed CIM defined as > 5 mm of tonsillar descent on head magnetic resonance imaging (MRI), we identified 20 patients who also had GHD. Read More

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http://dx.doi.org/10.1007/s00381-019-04370-2DOI Listing

Extradural Compressive Spinal Cerebrospinal Fluid Leak in Ehlers-Danlos Syndrome.

World Neurosurg 2019 Dec 31;132:67-68. Epub 2019 Aug 31.

Victor Horsley Department of Neurosurgery, National Hospital for Neurology and Neurosurgery, Queen Square, London, England.

Ehlers-Danlos syndrome can be associated with cerebrospinal fluid (CSF) disturbances including recurrent CSF leak and Chiari I malformations. Persistent pseudomeningoceles are known to be associated with raised intracranial pressure. We present an unusual case of a compressive epidural CSF collection occurring after a computed tomography-guided L5 nerve root block and describe an effective management strategy. Read More

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http://dx.doi.org/10.1016/j.wneu.2019.08.163DOI Listing
December 2019
5 Reads

The Chiari I malformation.

J Neurosurg Pediatr 2019 09;24(3):217-226

As with many pathologies, the course of our understanding of the Chiari I malformation (CIM) has developed extensively over time. The early descriptions of the Chiari malformations by Hans Chiari in 1891 opened the door for future classification and research on this topic. However, even over a long timeframe, our understanding of the pathophysiology and, more importantly, treatment, remained in its infancy. Read More

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http://dx.doi.org/10.3171/2019.5.PEDS18382DOI Listing
September 2019
7 Reads

Fetal myelomeningocele repair.

Semin Pediatr Surg 2019 Aug 18;28(4):150823. Epub 2019 Jul 18.

Division of Pediatric General, Thoracic and Fetal Surgery, University of California Davis Medical Center, 2335 Stockton Blvd, Room 5107, Sacramento, CA 95817, USA.

Myelomeningocele is a congenital malformation that causes a spectrum of morbidity. With the standard of care now being in utero repair, the spectrum of morbidity has changed. The purpose of this article is to review the diagnosis, workup and treatment options of fetal myelomeningocele. Read More

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http://dx.doi.org/10.1053/j.sempedsurg.2019.07.006DOI Listing
August 2019
1 Read

Cerebellar atrophy with Chiari malformation: An example of trans-synaptic degeneration?

J Clin Neurosci 2019 Nov 22;69:279-280. Epub 2019 Aug 22.

Neurosciences Department, Monash Medical Centre, Clayton, Australia; Department of Medicine, School of Clinical Sciences, Monash University, Clayton, Australia.

A 23-year old man was found to have a Chiari Type 1 malformation and cerebellar atrophy. While this association has previously been described, the remote cerebellar atrophy is difficult to explain. We believe the answer lies with our finding of signal hyperintensity on MR imaging at the level of the inferior olives. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09675868193104
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http://dx.doi.org/10.1016/j.jocn.2019.08.005DOI Listing
November 2019
1 Read

Reversible Central Hypoventilation Syndrome in Basilar Invagination.

World Neurosurg 2019 Nov 7;131:120-125. Epub 2019 Aug 7.

Department of Spine Services, Indian Spinal Injuries Centre, New Delhi, India.

Background: A noninvasive approach for basilar invagination (BI) and moreover, cervical traction to reduce odontoid invagination, has not been thoroughly described in the literature. We report a case of BI with Arnold-Chiari malformation in which preoperative reduction using Gardner well cervical traction was attempted and the patient developed central hypoventilation syndrome.

Case Description: A 15-year-old boy presented with a 6-month history of progressive cervical myelopathy signs and symptoms, modified Japanese orthopedic association score 12 of 18. Read More

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http://dx.doi.org/10.1016/j.wneu.2019.07.236DOI Listing
November 2019
6 Reads
2.417 Impact Factor

Hydrocephalus after foramen magnum decompression for Chiari I malformation successfully treated with the aspiration of pseudomeningocele: a case report.

J Med Case Rep 2019 Aug 6;13(1):243. Epub 2019 Aug 6.

Department of Orthopedic Surgery, Akita University Graduate School of Medicine, 1-1-1 Hondo, Akita, 010-8543, Japan.

Background: Pseudomeningocele or cerebrospinal fluid leakage is one of the most common complications of foramen magnum decompression with duraplasty for Chiari I malformation. Usually, cerebrospinal fluid leakage is treated with lumbar drainage and/or secondary suture. However, if hydrocephalus occurs, spinal drainage may cause brain herniation. Read More

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http://dx.doi.org/10.1186/s13256-019-2191-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6683535PMC
August 2019
4 Reads

Chiari I malformation in children-the natural history.

Childs Nerv Syst 2019 10 30;35(10):1793-1799. Epub 2019 Jul 30.

Department of Neurological Surgery, University of Virginia Health System, P.O. Box 800212, Charlottesville, VA, 22908-0711, USA.

Purpose: To review the natural history of asymptomatic and symptomatic pediatric Chiari I malformations with and without syringomyelia.

Materials And Methods: We reviewed the literature for case reports and case series describing the natural history of asymptomatic and symptomatic children with Chiari I malformations with and without syringomyelia. Our review included approximately 700 asymptomatic children without syringomyelia, 100 symptomatic children without syringomyelia, 22 asymptomatic children with syringomyelia, and 11 symptomatic children with syringomyelia. Read More

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http://dx.doi.org/10.1007/s00381-019-04310-0DOI Listing
October 2019
2 Reads

Spontaneous Resolution of Syringomyelia with a 16-Year Serial Magnetic Resonance Imaging Follow-Up: A Case Report and Literature Review.

World Neurosurg 2019 Oct 24;130:432-438. Epub 2019 Jul 24.

Department of Neurosurgery, Xuanwu Hospital of Capital Medical University, Beijing, China. Electronic address:

Background: The natural course of syringomyelia is unpredictable. Only a few cases of adults with spontaneous resolution of syringomyelia associated with Chiari malformation type I (CM-I) have been reported. The timing of surgical intervention for syringomyelia remains controversial. Read More

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http://dx.doi.org/10.1016/j.wneu.2019.07.138DOI Listing
October 2019
2 Reads

Intraoperative neurophysiological monitoring in paediatric Chiari surgery-help or hindrance?

Childs Nerv Syst 2019 10 25;35(10):1769-1776. Epub 2019 Jul 25.

Consultant Paediatric Neurosurgeon, Great Ormond Street Hospital for Children NHS Foundation Trust, London, WC1N 3JH, UK.

Introduction: The role of intraoperative neurophysiological monitoring (IONM) during surgery for Chiari I malformation has not been fully elucidated. Questions remain regarding its utility as an adjunct to foramen magnum decompression surgery, specifically, does IONM improve the safety profile of foramen magnum decompression surgery and can IONM parameters help in intraoperative surgical decision-making. This study aimed to describe a single institution experience of IOM during paediatric Chiari I surgery. Read More

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http://dx.doi.org/10.1007/s00381-019-04312-yDOI Listing
October 2019

Magnetic resonance imaging findings in a patient with cryopyrin-associated periodic syndrome: A rare hereditary multi-system inflammatory disorder.

Neuroradiol J 2019 Dec 24;32(6):420-425. Epub 2019 Jul 24.

Ann and Robert H. Lurie Children's Hospital of Chicago, USA.

Cryopyrin-associated periodic syndrome is a hereditary inflammatory disorder encompassing a wide spectrum of clinical phenotypes. This disorder has been associated with mutation of the gene coding for cryopyrin, which leads to overproduction of interleukin-1. The condition causes relapsing bouts of inflammation involving multiple organ systems, including the central nervous system, and, if untreated, can lead to long-term debilitating effects. Read More

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http://dx.doi.org/10.1177/1971400919863712DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6856997PMC
December 2019
2 Reads

Significance of Modified Clivoaxial Angles in the Treatment of Adult Chiari Malformation Type I.

World Neurosurg 2019 Oct 12;130:e1004-e1014. Epub 2019 Jul 12.

Department of Neurosurgery, Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan Province, People's Republic of China.

Objective: To investigate the influence of modified clivoaxial angle (MCAA) on the surgical planning and outcome in adult patients with Chiari malformation type I.

Methods: Clinical data of 268 adult patients undergoing posterior fossa decompression without (PFD) or with duraplasty (PFDD) or with resection of tonsils (RT) for Chiari malformation type I over 10 years were reviewed retrospectively, with outcome evaluated by Chicago Chiari Outcome Scale (CCOS) score. By means of receiver operating characteristic curve, the threshold of MCAA was calculated to stratify the patients. Read More

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http://dx.doi.org/10.1016/j.wneu.2019.07.060DOI Listing
October 2019
3 Reads
2.417 Impact Factor

Behavioral and clinical signs of Chiari-like malformation-associated pain and syringomyelia in Cavalier King Charles spaniels.

J Vet Intern Med 2019 Sep 9;33(5):2138-2150. Epub 2019 Jul 9.

School of Veterinary Medicine, Faculty of Health & Medical Sciences, University of Surrey, Surrey, United Kingdom.

Background: Diagnosis of Chiari-like malformation-associated pain (CM-P) or clinically relevant syringomyelia (SM) is challenging. We sought to determine common signs.

Animals: One hundred thirty client-owned Cavalier King Charles spaniels with neuroaxis magnetic resonance imaging (MRI) and diagnosis of CM-P/SM. Read More

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http://dx.doi.org/10.1111/jvim.15552DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6766577PMC
September 2019
2 Reads

Teaching Video NeuroImages: Cerebellar esotropia: A pitfall in ophthalmology and neurology.

Neurology 2019 07;93(1):e114-e115

From the Department of Ophthalmology (A.-C.C.), Centre Hospitalier, University of Liege, Belgium; Department of Neuro-ophthalmology (G.T.P.), National Hospital for Neurology and Neurosurgery, London; and Department of Clinical and Motor Neurosciences (D.K.), University College London, UK.

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http://dx.doi.org/10.1212/WNL.0000000000007729DOI Listing
July 2019
1 Read

Spinal Dysraphia, Chiari 2 Malformation, Unified Theory, and Advances in Fetoscopic Repair.

Neuroimaging Clin N Am 2019 Aug 30;29(3):357-366. Epub 2019 Apr 30.

Edward B. Singleton Department of Radiology, Texas Children's Hospital, 6701 Fannin Street, Suite 470, Houston, TX 77030, USA.

Fetal spina bifida, the most common nonlethal birth defect of the central nervous system, results in substantial neurologic morbidity. The unified theory describes the complex relationship between local spinal lesions and development of Chiari 2 malformation, contributing to hydrocephalus. Prenatal ultrasonography reliably allows diagnosis, but fetal MR imaging is an important complement to identify additional brain abnormalities. Read More

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http://dx.doi.org/10.1016/j.nic.2019.03.002DOI Listing
August 2019
5 Reads