1,667 results match your criteria Imaging in CNS Tuberculosis


Clinical features of aseptic meningitis with varicella zoster virus infection diagnosed by next-generation sequencing: case reports.

BMC Infect Dis 2020 Jun 22;20(1):435. Epub 2020 Jun 22.

Department of Neurology, Northern Jiangsu People's Hospital, Medical College of Yangzhou University, Yangzhou, 225001, China.

Background: The aseptic meningitis caused by varicella zoster virus (VZV) reactivation was less described in the literature, most of which were detected by means of polymerase chain reaction. The authors presented 4 adult immunocompetent patients with acute aseptic meningitis with VZV infection diagnosed by next-generation sequencing (NGS).

Case Presentation: Four patients were admitted to the hospital with headache and fever between March 2018 and August 2019. Read More

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http://dx.doi.org/10.1186/s12879-020-05155-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7309994PMC

Clinical analysis in immunocompetent and immunocompromised patients with pulmonary cryptococcosis in western China.

Sci Rep 2020 Jun 10;10(1):9387. Epub 2020 Jun 10.

Center of Infectious Disease, West China Hospital, Sichuan University, 37 Guoxue Lane, Chengdu, 610041, China.

Cryptococcosis is a systemic infection and it may occur in immunocompromised and immunocompetent hosts. In order to better understand the clinical characteristics of patients with PC in different immune status, we retrospectively investigated the clinical, radiological, and treatment profiles of immunocompetent and immunocompromised patients with PC during a 10-year period (2008-2017). As a result, out of 136 patients, 94 (69. Read More

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http://dx.doi.org/10.1038/s41598-020-66094-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7287058PMC
June 2020
5.078 Impact Factor

Preclinical models to optimize treatment of tuberculous meningitis - A systematic review.

Tuberculosis (Edinb) 2020 May 31;122:101924. Epub 2020 Mar 31.

Department of Pharmacy, Radboud Institute for Health Sciences, Radboud University Medical Center, Geert Grooteplein Zuid 10, 6525, GA, Nijmegen, the Netherlands. Electronic address:

Tuberculous meningitis (TBM) is the most devastating form of TB, resulting in death or neurological disability in up to 50% of patients affected. Treatment is similar to that of pulmonary TB, despite poor cerebrospinal fluid (CSF) penetration of the cornerstone anti-TB drug rifampicin. Considering TBM pathology, it is critical that optimal drug concentrations are reached in the meninges, brain and/or the surrounding CSF. Read More

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http://dx.doi.org/10.1016/j.tube.2020.101924DOI Listing

Vertebral tuberculosis as a paradoxical reaction to the treatment of pulmonary and meningeal tuberculosis in an immunocompetent patient: A case report.

Medicine (Baltimore) 2020 May;99(21):e20012

School of Medicine at Federal University of Mato Grosso do Sul, Campo Grande, Mato Grosso do Sul, Brazil.

Introduction: Paradoxical reaction in tuberculosis (TB) is defined as the reappearance of general symptoms, aggravation of pre-existing diseases, or appearance of new lesions despite adequate anti-TB therapy. It may result from the hyperactivity of the immune response, resulting in an intense inflammation. There are few cases of vertebral TB reported as paradoxical reaction, mainly among immunocompetents patients. Read More

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http://dx.doi.org/10.1097/MD.0000000000020012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7249907PMC

Challenges in the diagnosis of tuberculous meningitis.

J Clin Tuberc Other Mycobact Dis 2020 Aug 11;20:100164. Epub 2020 May 11.

Institute of Human Virology, University of Maryland School of Medicine, 725 W Lombard St, Baltimore, MD 21201, United States.

Tuberculosis (TB) continues to pose a significant public health problem. Tuberculous meningitis (TBM) is the most severe form of extra-pulmonary TB. TBM carries a high mortality rate, including for those receiving treatment for TB. Read More

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http://dx.doi.org/10.1016/j.jctube.2020.100164DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7240715PMC

Extra-central nervous system tuberculosis in HIV-uninfected patients of tuberculous meningitis: A prospective evaluation.

J Infect Public Health 2020 May 18. Epub 2020 May 18.

Department of Neurology, King George Medical University, Lucknow, Uttar Pradesh, 226003, India.

Objective: Disseminated tuberculosis is characterized with involvement of two or more non-contiguous sites. In this work we evaluated patients of tuberculous meningitis for possible extra-central nervous system tuberculosis.

Method: This prospective observational study was performed at a tertiary care institute in Northern India. Read More

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http://dx.doi.org/10.1016/j.jiph.2020.04.011DOI Listing

Real-time polymerase chain reaction for Mycobacterium tuberculosis meningitis is more sensitive in patients with HIV co-infection.

Curr HIV Res 2020 May 4. Epub 2020 May 4.

Bacteriology Laboratory, Hospital de Clínicas, Universidade Federal do Paraná, Curitiba, Paraná. Brazil.

Background: Tuberculous meningitis (TbM) is the most severe complication of extrapulmonary tuberculosis (Tb). There is higher frequency of positive cerebrospinal fluid (CSF) cultures for Mycobacterium tuberculosis (MTb) in samples from human immunodeficiency virus (HIV) co-infected patients than in those from HIV-negative patients. We hypothesized that real time PCR assays for MTb (MTb qPCR) using CSF would be more sensitive in HIV co-infected patients owing to a greater MTb burden. Read More

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http://dx.doi.org/10.2174/1570162X18666200505083728DOI Listing

Management of intracranial tuberculous mass lesions: how long should we treat for?

Wellcome Open Res 2019 31;4:158. Epub 2019 Oct 31.

Wellcome Centre for Infectious Diseases Research in Africa, Institute of Infectious Disease and Molecular Medicine, Department of Medicine, University of Cape Town, Cape Town, 7925, South Africa.

Tuberculous intracranial mass lesions are common in settings with high tuberculosis (TB) incidence and HIV prevalence. The diagnosis of such lesions, which include tuberculoma and tuberculous abscesses, is often presumptive and based on radiological features, supportive evidence of TB elsewhere and response to TB treatment. However, the treatment response is unpredictable, with lesions frequently enlarging paradoxically or persisting for many years despite appropriate TB treatment and corticosteroid therapy. Read More

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http://dx.doi.org/10.12688/wellcomeopenres.15501.2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6996525.2PMC
October 2019

[Intramedullary Pott's abscess: a case study].

Pan Afr Med J 2019 6;34:186. Epub 2019 Dec 6.

Service de Neurochirurgie, Hôpital National de Niamey, Niamey, République du Niger.

Central Nervous System (CNS) Tuberculosis (TB) is rare. It manifests in many forms, but the association between intramedullary abscess and multifocal Pott's disease is exceptional. We report the case of a 23-year old female patient diagnosed with multifocal Pott's disease at L2-L3 and L4-L5 based on computed tomography (CT) scan of the spine. Read More

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http://dx.doi.org/10.11604/pamj.2019.34.186.20838DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7060905PMC
December 2019

Clinical, Imaging, and Laboratory Characteristics of Adult Mexican Patients with Tuberculous Meningitis: A Retrospective Cohort Study.

J Epidemiol Glob Health 2020 03;10(1):59-64

Department of Neurology and Psychiatry, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, México.

Tuberculous Meningitis (TBM) is the most common form of central nervous system Tuberculosis (TB), accounting for 5-6% of extrapulmonary TB cases. Nowadays, TBM continues to be a major topic in public health because of its high prevalence worldwide. This retrospective study aimed to describe the clinical, laboratory, and imaging characteristics at admission; and in-hospital outcome of adult Mexican patients with TBM. Read More

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http://dx.doi.org/10.2991/jegh.k.191023.001DOI Listing

Brain abscess in a patient with psoriatic arthritis treated with adalimumab: A case report.

Medicine (Baltimore) 2020 Mar;99(10):e18954

Department of Dermatology, China Medical University Hospital.

Rationale: In patients receiving biological therapies, serious infections are a major concern. Infections associated with anti-tumor necrosis factor antibody therapy include tuberculosis, viral, fungal, and bacterial infections. Likewise, severe infections of the upper and lower respiratory tract, lung, skin and soft tissue, urinary tract, gastrointestinal tract, joint, and bone have also been reported previously. Read More

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http://dx.doi.org/10.1097/MD.0000000000018954DOI Listing

Central nervous system tuberculoma with miliary tuberculosis in the elderly.

IDCases 2020 29;19:e00710. Epub 2020 Jan 29.

Department of Neurology, International University of Health and Welfare Hospital, 537-3, Iguchi, Nasushiobara, Tochigi, 329-2763, Japan.

The aging phenomenon of tuberculosis (TB) patients is recognized all over the world, but no country is as prominent as Japan. Central nervous system (CNS) TB includes clinical entities: tuberculous meningitis, intracranial tuberculoma, and clinical features of CNS TB in the elderly may be atypical, non-specific, and confused with concomitant age-related diseases. Atypical clinical manifestations of TB in older persons can result in delay in diagnosis and initiation of treatment. Read More

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http://dx.doi.org/10.1016/j.idcr.2020.e00710DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7005458PMC
January 2020

An unusual presentation of gross cerebral vascular dilatation in a TB/HIV co-infected individual.

Br J Neurosurg 2020 Feb 8:1-4. Epub 2020 Feb 8.

Department of Neurosurgery, Tygerberg Hospital, Cape Town, South Africa.

Aneurysmal dilatation secondary to HIV vasculitis is well described being more common in patients under 45 years of age with advanced stage HIV infection (CD4 < 200 cells/µl). Tuberculous meningitis is far more common than previously anticipated with centres in Cape Town publishing that more than half of all cases of adult meningitis were secondary to tuberculosis. But aneurysmal dilatation of the cerebral vessels is exceedingly rare complication in this population. Read More

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http://dx.doi.org/10.1080/02688697.2020.1725439DOI Listing
February 2020

Microbiological diagnosis of tuberculous meningitis: Phenotype to genotype.

Indian J Med Res 2019 11;150(5):448-457

Department of Neurology, King George Medical University, Lucknow, Uttar Pradesh, India.

Tuberculous meningitis (TBM) is a commonly encountered central nervous system infection. Characteristic clinical, imaging and cerebrospinal fluid parameters help clinicians to make a prompt presumptive diagnosis that enables them to start empirical anti-tuberculosis treatment. There are several close mimic to TBM, such as partially treated pyogenic meningitis, fungal meningitis, sarcoidosis, meningeal metastases and meningeal lymphomatosis. Read More

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http://dx.doi.org/10.4103/ijmr.IJMR_1145_19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6977359PMC
November 2019

Intensified adjunctive corticosteroid therapy for CNS tuberculomas.

Infection 2020 Apr 3;48(2):289-293. Epub 2020 Jan 3.

Division of Infectious Diseases, Department I of Internal Medicine, University of Cologne, Cologne, Germany.

Introduction: Central nervous system (CNS) tuberculomas are a challenging manifestation of extrapulmonary tuberculosis often leading to neurological complications and post-treatment sequelae. The role of adjunctive corticosteroid treatment is not fully understood. Most guidelines on management of tuberculosis do not distinguish between tuberculous meningitis and CNS tuberculomas in terms of corticosteroid therapy. Read More

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http://dx.doi.org/10.1007/s15010-019-01378-3DOI Listing

Mycobacterium tuberculosis and Pseudoramibacter alactolyticus coinfection in brain after dental extraction: A case report.

Medicine (Baltimore) 2019 Dec;98(50):e18289

Department of Infectious Diseases.

Introduction: More than 1200 different types of microbes were found in the human mouth, only some of these microorganisms were associated with intracranial bacterial infection. However, there are limited data available about the Pseudoramibacter alactolyticus (P alactolyticus) or Mycobacterium tuberculosis (MTB) intracranial infections oral origin.

Patient Concerns: Here, we reported a rarely case with P alactolyticus and MTB coinfection in central nervous after dental extraction. Read More

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http://dx.doi.org/10.1097/MD.0000000000018289DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6922595PMC
December 2019

Use of Ultra-Deep Sequencing in a Patient with Tuberculous Coxitis Shows Its Limitations in Extrapulmonary Tuberculosis Diagnostics: A Case Report.

Infect Drug Resist 2019 29;12:3739-3743. Epub 2019 Nov 29.

NHC Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, People's Republic of China.

Unbiased metagenomic next-generation sequencing (mNGS) has been widely applied in clinical microbiology for infectious disease diagnostics. Some successful applications in central nervous system infections and respiratory tract infections have proved it to be a promising tool for pathogen detection. Here, mNGS was used to confirm the infectious etiology in a case of tuberculous coxitis, which is a common type of extrapulmonary tuberculosis (TB). Read More

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http://dx.doi.org/10.2147/IDR.S226518DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6890184PMC
November 2019

18FDG-PET is sensitive tool for detection of extracranial tuberculous foci in central nervous system tuberculosis - Preliminary observations from a tertiary care center in northern India.

J Neurol Sci 2020 Feb 27;409:116585. Epub 2019 Nov 27.

Department of Neurology, Postgraduate Institute of Medical Education and Research, Chandigarh 160012, India.

Purpose: To study the role of 18FDG- PET (Flourodeoxyglucose positron emission tomography) in a) determining the extent of cranial and extra-cranial disease and b) diagnosis as well as prognosis of CNS TB (central nervous system tuberculosis) including TBM (tuberculous meningitis).

Patients And Methods: This prospective observational study (n = 70) was carried out at a tertiary care institute in Northern India from 1.1. Read More

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http://dx.doi.org/10.1016/j.jns.2019.116585DOI Listing
February 2020

Folate receptor-targeted positron emission tomography of experimental autoimmune encephalomyelitis in rats.

J Neuroinflammation 2019 Dec 3;16(1):252. Epub 2019 Dec 3.

Turku PET Centre, University of Turku, Turku, Finland.

Background: Folate receptor-β (FR-β) is a cell surface receptor that is significantly upregulated on activated macrophages during inflammation and provides a potential target for folate-based therapeutic and diagnostic agents. FR-β expression in central nervous system inflammation remains relatively unexplored. Therefore, we used focally induced acute and chronic phases of experimental autoimmune encephalomyelitis (EAE) to study patterns of FR-β expression and evaluated its potential as an in vivo imaging target. Read More

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http://dx.doi.org/10.1186/s12974-019-1612-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6892159PMC
December 2019

Tuberculous encephalopathy without meningitis: A rare manifestation of disseminated tuberculosis.

Int J Mycobacteriol 2019 Oct-Dec;8(4):406-408

Department of Medicine, VMMC and Safdarjung Hospital, Delhi, India.

Tuberculous (TB) encephalopathy is a rare presentation of the central nervous system tuberculosis. Its pathophysiology is believed to have an immune mechanism without any direct invasion by the tubercular bacilli. The clinical presentation is highly variable from mild illness to a potentially fatal one. Read More

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http://dx.doi.org/10.4103/ijmy.ijmy_131_19DOI Listing

Sigmoid Sinus Thrombosis with Cerebellar Tuberculous Abscess: A Rare Case of Chronic Headache with Vision Loss.

J Coll Physicians Surg Pak 2019 Dec;29(12):S109-S111

Department of Neurology, Rajshahi Medical College Hospital, Rajshahi, Bangladesh.

Cerebral venous sinus thrombosis (CVST) is a rare form of brain stroke which is often misdiagnosed. We present a case of CVST due to cerebellar tuberculous abscess. A 41-year female patient was admitted with chronic occipital headache, diminished vision, and fever. Read More

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http://dx.doi.org/10.29271/jcpsp.2019.12.S109DOI Listing
December 2019
0.318 Impact Factor

Diagnosis and management of intracranial tuberculomas: about 2 cases and a review of the literature.

Pan Afr Med J 2019 11;34:23. Epub 2019 Sep 11.

Neurosurgery Department, Ibn-Tofail Hospital, Marrakech, Morocco.

Central nervous system tuberculosis is a major cause of morbidity and mortality in developing countries. Intracranial tuberculoma is rare and is one of the most severe cases of tuberculosis. We present two cases. Read More

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http://dx.doi.org/10.11604/pamj.2019.34.23.17587DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6859027PMC
December 2019

Multiple Cranial Tuberculomas Without Meningitis in Two Infants With Miliary Tuberculosis.

Pediatr Infect Dis J 2019 12;38(12):e337-e339

Section of Pediatric Infectious Diseases, Baylor College of Medicine.

Magnetic resonance imaging may detect central nervous system involvement even when cerebrospinal fluid is normal and tests to detect Mycobacterium tuberculosis are negative. We describe 2 cases of miliary tuberculosis in young children with clinically unexpected central nervous system involvement. Magnetic resonance imaging of the brain should be considered part of the initial diagnostic workup for miliary tuberculosis in very young children. Read More

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http://dx.doi.org/10.1097/INF.0000000000002464DOI Listing
December 2019

Extrapulmonary Tuberculosis: Pathophysiology and Imaging Findings.

Radiographics 2019 Nov-Dec;39(7):2023-2037

From the Department of Radiology, Fundación Valle del Lili-Universidad Icesi, Carrera 98 #18-49, Cali, Colombia.

Extrapulmonary tuberculosis (TB) represents approximately 15% of all TB infections. It is difficult to diagnose on the basis of imaging characteristics and clinical symptoms, and biopsy is required in many cases. Radiologists must be aware of the imaging findings of extrapulmonary TB to identify the condition in high-risk patients, even in the absence of active pulmonary infection. Read More

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http://dx.doi.org/10.1148/rg.2019190109DOI Listing
November 2019

Central Nervous System involvement in tuberculosis: An MRI study considering differences between patients with and without Human Immunodeficiency Virus 1 infection.

J Neuroradiol 2019 Sep 17. Epub 2019 Sep 17.

NESMOS Department University of Rome Sapienza. Azienda Ospedaliero-Universitaria Sant'Andrea, Roma, Italy.

Background: Magnetic resonance imaging (MRI) is largely used in the diagnosis of central nervous system involvement of tuberculosis (CNSTB), yet there is no MRI comparison study between HIV+ and HIV- patients with CNSTB. The aim of the present study was to identify MRI differences in CNSTB between HIV+ and HIV- patients and possibly find early characteristics that could raise the suspect of this disease.

Methods: We included all patients admitted in our institution between 2011 and 2018 with confirmed diagnosis of CNSTB, and MRI performed in the first week. Read More

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http://dx.doi.org/10.1016/j.neurad.2019.07.008DOI Listing
September 2019
1 Read

Infectious Etiologies of Stroke.

Semin Neurol 2019 08 18;39(4):482-494. Epub 2019 Sep 18.

Boston University School of Medicine, Boston University, Boston, Massachusetts.

Central nervous system (CNS) infections are a frequently underappreciated potential etiology of cerebrovascular disease. Highlighted in this review are a selection of infectious agents that lead to cerebrovascular complications through various mechanisms including multifocal vasculopathy, focal infiltrative vasculitis and vasospasm, and direct vessel wall invasion and thrombus formation. Diagnosis of stroke due to underlying CNS infection requires a high index of clinical suspicion and careful consideration of neuroimaging, serum, and cerebrospinal fluid studies in addition to a detailed history and neurologic examination. Read More

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http://www.thieme-connect.de/DOI/DOI?10.1055/s-0039-1687915
Publisher Site
http://dx.doi.org/10.1055/s-0039-1687915DOI Listing
August 2019
4 Reads

Neurotuberculosis: A Clinical Review.

Authors:
Jerome H Chin

Semin Neurol 2019 08 18;39(4):456-461. Epub 2019 Sep 18.

Department of Neurology, NYU Langone Health, New York, New York.

In September 2018, the United Nations General Assembly held the first ever meeting to discuss the global epidemic of tuberculosis (TB) and adopted a political declaration titled "United to end tuberculosis: an urgent global response to a global epidemic." The timing of the meeting was prescient but overdue since surpassed the human immunodeficiency virus as the world's leading infectious killer in 2014. Infection of the central nervous system by , herein referred to as neurotuberculosis, is the most feared and dangerous form of tuberculosis, requiring a high level of suspicion and clinical experience for prompt diagnosis and treatment. Read More

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http://dx.doi.org/10.1055/s-0039-1687840DOI Listing

Primary Pituitary Tubercular Abscess: A Case Report.

JNMA J Nepal Med Assoc 2019 May-Jun;57(217):206-208

Department of Pathology, Neuro Cardio and MultiSpeciality Hospital, Biratnagar, Nepal.

Primary pituitary tubercular abscess is a very rare disease. It may present clinically with visual loss, headache, seizure, hormonal abnormalities or with cranial nerve palsies. MRI is the diagnostic modality and shows a cystic-solid mass in the sellar and suprasellar region, isointense on T1 and T2W images with heterogeneous areas and ring enhancement on contrast. Read More

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February 2020
0.174 Impact Factor

Intracerebral tuberculomas: A rare cause of seizure in an immunocompetent young male.

IDCases 2019 7;18:e00599. Epub 2019 Aug 7.

Grand Strand Medical Center, United States.

Central nervous system (CNS) involvement occurs in about 1% of all tuberculosis (TB) cases, classically presenting as a meningitis. Intracerebral tuberculomas are a much rarer manifestation. We describe the case of a young black male who presented with new-onset seizure. Read More

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http://dx.doi.org/10.1016/j.idcr.2019.e00599DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6704045PMC
August 2019
1 Read

Extranodal natural killer/T-cell lymphoma nasal type with central nervous system involvement mimicked tuberculous meningitis: A case report.

Medicine (Baltimore) 2019 Aug;98(34):e16747

Department of Neurology, First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.

Rationale: Neurologic deficits are rare in patients with extranodal natural killer/T-cell lymphoma (NKTL), nasal type. We present a case that was initially suspected as tuberculous meningitis, but later diagnosed as central nervous system metastasis of NKTL, nasal type, which has never been published previously.

Patient Concerns: A 55-year-old Chinese man presented with persistent headache and fever. Read More

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http://dx.doi.org/10.1097/MD.0000000000016747DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6716710PMC
August 2019
5 Reads

Central Nervous System Tuberculoma Complicated with Spinal Arachnoiditis in Immunocompetent Patient.

Open Access Maced J Med Sci 2019 Jun 30;7(12):2002-2005. Epub 2019 Jun 30.

Neurosurgery Departement Faculty of Medicine Udayana University, Sanglah Hospital Denpasar, Bali, Indonesia.

Background: Central nervous system (CNS) tuberculosis (TB) can manifest as meningitis, abscess, tuberculoma or other manifestations. CNS TB is a rare TB complication, and its diagnosis remains a challenge since it has clinical and imaging features that resemble other diseases. The antituberculosis treatment has a significant role in determining a patient's outcome and prevent complications and mortality. Read More

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http://dx.doi.org/10.3889/oamjms.2019.272DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6684426PMC
June 2019
12 Reads

The Utility of CSF Xpert MTB/RIF in Diagnosis of Tubercular Meningitis in Children.

Indian J Pediatr 2019 12 19;86(12):1089-1093. Epub 2019 Jul 19.

Department of Pediatrics, Karnataka Institute of Medical Sciences, Hubli, Karnataka, 580021, India.

Objective: To determine the utility of CSF Xpert MTB/RIF (GeneXpert) in diagnosis of tubercular meningitis in children in the age group of 2 mo to 12 y.

Methods: This hospital based prospective observational study was conducted at Department of Pediatrics, Karnataka Institute of Medical Sciences (KIMS), Hubli from December 2015 through November 2016. All children with clinically suspected tuberculous meningitis (TBM) were included in the study. Read More

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http://dx.doi.org/10.1007/s12098-019-03032-0DOI Listing
December 2019
2 Reads

[A case of tuberculous meningitis with pleural effusion as a manifestation of a paradoxical reaction during anti-tuberculosis therapy].

Rinsho Shinkeigaku 2019 Aug 23;59(8):541-544. Epub 2019 Jul 23.

Department of Respiratory Medicine, Seirei Mikatahara General Hospital.

We present a case of tuberculous meningitis (TBM), wherein pleural effusion developed as a manifestation of paradoxical reaction during anti-tuberculosis therapy. An 87-year-old diabetic man was referred to our clinic for fever and impaired consciousness. He did not obey vocal commands. Read More

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http://dx.doi.org/10.5692/clinicalneurol.cn-001309DOI Listing
August 2019
9 Reads

Multiple cerebral sinus venous thrombosis and venous infarct: rare complication of tuberculous meningitis in a child.

BMJ Case Rep 2019 Jul 22;12(7). Epub 2019 Jul 22.

Radiodiagnosis and Imaging, Post Graduate Institute of Medical Education and Research, Chandigarh, India.

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http://dx.doi.org/10.1136/bcr-2019-231419DOI Listing
July 2019
4 Reads

Early Syringomyelia in Tubercular Meningitis.

J Assoc Physicians India 2018 Oct;66(10):90-91

Senior Resident Neurosurgery, N.S.C.B. Medical College Jabalpur, Madhya Pradesh.

Tubercular meningitis (TBM) can have various complications. Sometimes syringomyelia can also occur as a late complication of tubercular meningitis. Although syrinx formation in early stage of TBM is very rare. Read More

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October 2018
5 Reads

Symptomatic central nervous system tuberculoma, a case report in the United States and literature review.

IDCases 2019 25;17:e00582. Epub 2019 Jun 25.

Division of Infectious Diseases, Indiana University School of Medicine, Indianapolis, IN, USA.

Intracranial tuberculoma is one of the rare central nervous system manifestations of (MTB), seen in only 1% of tuberculosis patients. It can manifest as single or multiple lesions, most commonly located in the frontal and parietal lobes. Clinical features are similar to any space-occupying lesion in the brain and can present in the absence of MTB symptoms in other parts of the body. Read More

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http://dx.doi.org/10.1016/j.idcr.2019.e00582DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6610223PMC
June 2019
2 Reads

[Cerebral tuberculoma a diagnostic challenge: case study and update].

Pan Afr Med J 2019 10;32:176. Epub 2019 Apr 10.

Service de Neurochirurgie, CHU Ibn Sina, Rabat, Maroc.

Central nervous system (CNS) tuberculosis is the second most common presentation after tuberculous meningitis. It is a major cause of morbidity and mortality in the developing countries, accounting for 10-30% of intracranial expansive lesions in these countries against 0.2% in some Western countries. Read More

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http://dx.doi.org/10.11604/pamj.2019.32.176.16623DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6607260PMC
July 2019
3 Reads

TB or not TB?

Pract Neurol 2019 Oct 10;19(5):451-455. Epub 2019 Jul 10.

Manchester Centre for Clinical Neurosciences, Salford Royal NHS Foundation Trust, Salford, UK.

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http://dx.doi.org/10.1136/practneurol-2019-002258DOI Listing
October 2019
3 Reads

The susceptibility ring.

Br J Radiol 2019 08 9;92(1100):20190034. Epub 2019 Jul 9.

1 Department of Radiology, Kokilaben Dhirubhai Ambani Hospital, Mumbai, India.

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http://dx.doi.org/10.1259/bjr.20190034DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6724626PMC

Rare and unusual case of hepatic and disseminated tuberculosis in an immunocompetent patient.

BMJ Case Rep 2019 Jun 22;12(6). Epub 2019 Jun 22.

Department of Infection, Hull and East Yorkshire Hospitals NHS Trust, Hull, UK.

complex disease (tuberculosis (TB)) of the liver is rare and liver abscesses as a result are even rarer. In an immunocompetent individual, the disease tends to be localised. To the best of our knowledge, we report one of the most severe TB involvements of the liver in an immunocompetent individual. Read More

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http://dx.doi.org/10.1136/bcr-2019-229384DOI Listing
June 2019
19 Reads

Pineal Region Tuberculoma Caused by Mycobacterium bovis as a Complication of Bacille Calmette-Guérin Vaccine: Case Report and Review of the Literature.

World Neurosurg 2020 Jan 8;133:416-418. Epub 2019 Jun 8.

Skull Base Research Center, Loghman Hakim Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Background: Brain tuberculoma is a rare manifestation of tuberculosis especially in immunosuppressed patients. The definitive diagnosis may be difficult owing to mimicking brain tumors and the absence of the common presentation. Bacille Calmette-Guérin (BCG) vaccine is used for protection against tuberculous meningitis and miliary disease, more so in children, and also for the treatment of bladder cancer. Read More

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http://dx.doi.org/10.1016/j.wneu.2019.04.008DOI Listing
January 2020
9 Reads
2.417 Impact Factor

Tuberculosis Meningitis in a 10-Month-Old Living in an Immigrant Township.

Clin Pediatr (Phila) 2019 10 6;58(11-12):1341-1344. Epub 2019 Jun 6.

University of Texas, Houston, TX, USA.

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http://dx.doi.org/10.1177/0009922819852997DOI Listing
October 2019
5 Reads

[Tuberculoma of the right frontal lobe with epileptic seizures].

Zh Nevrol Psikhiatr Im S S Korsakova 2019 ;119(4):60-65

Almazov National Medical Research Center, St.-Petersburg, Russia.

Tuberculosis remains a serious global health issue. Tuberculosis of the central nervous system is the most frequent cause of chronic infection. Presented is a case of a 17 year-old patient with simple partial seizures with secondary generalization and increased intracranial pressure. Read More

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http://dx.doi.org/10.17116/jnevro201911904160DOI Listing
August 2019
15 Reads

Neuroimaging Findings in Tuberculosis: A Single-Center Experience in 559 Cases.

J Neuroimaging 2019 09 21;29(5):657-668. Epub 2019 May 21.

Department of Neurology, The Aga Khan University Hospital, Karachi, Pakistan.

Background And Purpose: There is a paucity of literature related to the neuroimaging of CNS tuberculosis (TB) and largely covers pediatric CNS TB. The objective of this study was to determine the frequency of different forms of CNS TB and its associated complications and to study longitudinal disease course using computed tomography (CT) and MRI.

Methods: Retrospective chart and imaging review of patients diagnosed with CNS TB in a tertiary care hospital in Pakistan over a 10-year period. Read More

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http://dx.doi.org/10.1111/jon.12627DOI Listing
September 2019
7 Reads
1.818 Impact Factor

Cerebral hemiatrophy: A delayed sequalae of multidrug-resistant tuberculous meningitis.

Neurol India 2019 Mar-Apr;67(2):614-615

Department of Neurology, King George Medical University, Lucknow, Uttar Pradesh, India.

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http://dx.doi.org/10.4103/0028-3886.257985DOI Listing
December 2019
6 Reads

Tuberculous meningoencephalitis in patient with HIV-infection.

QJM 2019 Dec;112(12):932-933

Saint-Petersburg State Research Institute of Phthisiopulmonology of the Ministry of Healthcare of the Russian Federation, Saint-Petersburg, Russia.

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http://dx.doi.org/10.1093/qjmed/hcz104DOI Listing
December 2019

Comments on 'magnetic resonance venographic findings in tuberculous meningitis'.

Magn Reson Imaging 2019 09 7;61:231-232. Epub 2019 May 7.

Department of Pediatrics, Maharishi Markandeshwar Institute of Medical Sciences and Research, Mullana, Ambala 133207, India. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S0730725X193018
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http://dx.doi.org/10.1016/j.mri.2019.05.010DOI Listing
September 2019
17 Reads
2.022 Impact Factor

Management of tuberculosis of the central nervous system: Our experience.

Authors:
P N Tandon

Natl Med J India 2018 May-Jun;31(3):151-155

Department of Neurosurgery, All India Institute of Medical Sciences, Ansari Nagar, New Delhi 110029; National Brain Research Society, Manesar, Haryana, India.

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http://dx.doi.org/10.4103/0970-258X.255758DOI Listing
October 2019
2 Reads

Acute ischemic stroke in young adults with tuberculous meningitis.

BMC Infect Dis 2019 Apr 30;19(1):362. Epub 2019 Apr 30.

Department of Neurology, Qianfoshan Hospital, Shandong University, Jinan, 250014, China.

Background: Ischemic stroke is a common complication in patients with tuberculous meningitis (TBM), which is associated with poor clinical outcome. However, risk factors of stroke in TBM patients were not fully understood, especially in those young adults. Therefore, the aim of our study was to identify risk factors for acute ischemic stroke in young adults with TBM. Read More

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https://bmcinfectdis.biomedcentral.com/articles/10.1186/s128
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http://dx.doi.org/10.1186/s12879-019-4004-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6492375PMC
April 2019
14 Reads

A case report of intraventricular and intrathecal tigecycline infusions for an extensively drug-resistant intracranial Acinetobacter baumannii infection.

Medicine (Baltimore) 2019 Apr;98(15):e15139

Department of Infectious Disease.

Rationale: The treatment of intracranial Acinetobacter baumannii infections is made difficult by multidrug-resistance poor drug penetration through the blood-brain barrier (BBB). Although tigecycline appears to be effective against A baumannii, it is only administered intravenously because it does not readily cross the BBB. The addition of intraventricular (IVT) or intrathecal infusions of tigecycline could revolutionize clinical therapy for intracranial A baumannii infections. Read More

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http://dx.doi.org/10.1097/MD.0000000000015139DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6485835PMC
April 2019
21 Reads