1,566 results match your criteria Imaging in CNS Tuberculosis


[Recurrent vomiting and headaches in a 26-year-old male patient].

Internist (Berl) 2019 Apr 12. Epub 2019 Apr 12.

I. Medizinische Klinik und Poliklinik, Universitätsklinikum Hamburg-Eppendorf, Hamburg, Deutschland.

This article reports the case of a 26-year-old male patient with recurrent emesis and headache due to central nervous system tuberculosis. The thoracic computed tomography showed bilateral disseminated pulmonary micronodular infiltrates and a cavern connecting to the bronchial system. The cranial magnetic resonance imaging showed multiple supratentorial and infratentorial microabscesses with concomitant meningitis. Read More

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http://link.springer.com/10.1007/s00108-019-0597-4
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http://dx.doi.org/10.1007/s00108-019-0597-4DOI Listing
April 2019
1 Read

Case report: an area postrema syndrome revealing a neuromyelitis optica spectrum disorder associated with central nervous system tuberculosis in a young Togolese (black African) woman.

BMC Neurol 2019 Apr 10;19(1):58. Epub 2019 Apr 10.

Faculte des Sciences de la Sante, Universite de Lome, BP 1515, Lome, Togo.

Background: Area postrema syndrome (APS) is considered to be one of the most specific clinical presentations of neuromyelitis optica spectrum disorders (NMOSDs). In sub-Saharan Africa, NMOSDs and even more so those revealed by an APS, are rarely reported. However, studies among mixed populations have shown that NMOSDs disproportionately affect black people with relatively more frequent encephalic involvement. Read More

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http://dx.doi.org/10.1186/s12883-019-1287-5DOI Listing
April 2019
2 Reads

Think central nervous system tuberculosis, also in low-risk children: a Danish nationwide survey.

Infect Dis (Lond) 2019 Mar 25:1-5. Epub 2019 Mar 25.

a Department of Pediatrics and Adolescence , Rigshospitalet University of Copenhagen , Copenhagen , Denmark.

Background: Paediatric central nervous system (CNS) tuberculosis (TB) imposes a high risk of death and neurologic sequelae, particularly if the diagnosis is delayed. Children from non-TB endemic countries are particularly at risk of delayed or missed diagnosis. We aimed to investigate CNS TB in Denmark, a TB low-endemic country and where Bacillus Calmette-Guerin (BCG) vaccination is not a part of the vaccination schedule. Read More

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https://www.tandfonline.com/doi/full/10.1080/23744235.2019.1
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http://dx.doi.org/10.1080/23744235.2019.1588471DOI Listing
March 2019
4 Reads

Magnetic resonance imaging spectrum of intracranial tubercular lesions: one disease, many faces.

Pol J Radiol 2018 29;83:e524-e535. Epub 2018 Dec 29.

Jackson Memorial Hospital, Miami, USA.

Tuberculosis is a devastating disease and has shown resurgence in recent years with the advent of acquired immunodeficiency syndrome. Central nervous system involvement is the most devastating form of the disease, comprising 10% of all tuberculosis cases. The causative organism, , incites a granulomatous inflammatory response in the brain, the effects of which can be appreciated on magnetic resonance imaging (MRI), which can thus be used for diagnosis of the same. Read More

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http://dx.doi.org/10.5114/pjr.2018.81408DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6384409PMC
December 2018

Tonic Seizure as a Different Seizure Type Presented in Autoimmune Epilepsy Caused by Systemic Lupus Erythematosus.

J Nerv Ment Dis 2019 Mar;207(3):188-191

Department of Neurology, Department of Neurology and Neuroscience Center, The First Hospital of JiLin University, Changchun, People's Republic of China.

The diagnosis of autoimmune epilepsy is often challenging, and may be misdiagnosed as epileptic disorders or viral encephalitis. Autoimmune epilepsy has a strong association with other autoimmune diseases, especially systemic lupus erythematosus (SLE). In addition, autoimmune epilepsy was reported to present with complex partial seizure (CPS), simple partial seizure (SPS), and secondarily generalized tonic-clonic seizure (sGTCS). Read More

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http://dx.doi.org/10.1097/NMD.0000000000000946DOI Listing
March 2019
4 Reads

A young woman with headache and vomiting.

BMJ 2019 Jan 30;364:l216. Epub 2019 Jan 30.

Department of Neurosurgery, James Cook University Hospital, Middlesbrough, UK.

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http://dx.doi.org/10.1136/bmj.l216DOI Listing
January 2019
1 Read

Practice Trends in Treating Central Nervous System Tuberculosis and Outcomes at a Tertiary Care Hospital: A Cohort Study of 244 Cases.

Ann Indian Acad Neurol 2019 Jan-Mar;22(1):37-46

Department of Neurology, AIIMS, New Delhi, India.

Introduction: Tubercular meningitis (TBM) is a common cause of chronic meningitis in India; however, there is a paucity of literature on optimum duration and choice of drug therapy.

Materials And Methods: This was an ambispective cohort study.

Results: Two hundred and forty-four patients of central nervous system tuberculosis (CNS TB) who were seronegative for HIV were studied of whom 198 had TBM and 46 patients had tuberculoma without meningitis. Read More

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http://dx.doi.org/10.4103/aian.AIAN_70_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6327709PMC
January 2019
2 Reads

[Intracranial tuberculomas in Nouakchott, Mauritania].

Pan Afr Med J 2018 9;30:269. Epub 2018 Aug 9.

Service de Neurochirurgie, Centre Hospitalier National de Nouakchott, Mauritanie.

Tuberculosis is a major public health problem in developing countries. Cerebral tuberculomas is a tuberculous granulation tissue mass restrained and limited by immune defenses of the host. This study aims to describe the characteristics and the evolutionary profile of intracranial tuberculomas in Mauritania. Read More

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http://dx.doi.org/10.11604/pamj.2018.30.269.15467DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6317400PMC
January 2019
13 Reads

Paediatric deaths in a tertiary government hospital setting, Malawi.

Paediatr Int Child Health 2018 Nov 19:1-9. Epub 2018 Nov 19.

g Centre for Medical Education , Queen's University , Belfast , UK.

Background: Malawisuccessfully achieved Millennium Development Goal (MDG) four by decreasing the under-5 mortality rate by two-thirds in 2012. Despite this progress child mortality is still high and in 2013, the leading causes of death in under-5s were malaria, acute respiratory infections and HIV/AIDS.

Aims: To determine the causes of inpatient child death including microbiological aetiologies in Malawi. Read More

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https://www.tandfonline.com/doi/full/10.1080/20469047.2018.1
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http://dx.doi.org/10.1080/20469047.2018.1536873DOI Listing
November 2018
19 Reads

Atypical Clinical Presentation and Imaging Findings of Central Nervous System Tuberculosis.

Can J Neurol Sci 2018 11;45(6):686-687

1Division of Neurology,Department of Medicine,University of Toronto,Toronto,Ontario,Canada.

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https://www.cambridge.org/core/product/identifier/S031716711
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http://dx.doi.org/10.1017/cjn.2018.356DOI Listing
November 2018
12 Reads

Cerebral tuberculomas in a 6-year-old girl causing central diabetes insipidus.

BMJ Case Rep 2018 Nov 12;2018. Epub 2018 Nov 12.

Consultant Paediatric Infectious Diseases and Immunology, Imperial College Healthcare NHS Trust, St Mary's Hospital, London, UK.

A 6-year-old girl presented acutely with worsening frontal headaches. She had a 3-month history of lethargy, reduced appetite, weight loss, cough and intermittent fevers. A chest X-ray showed a left upper lobe consolidation, and a CT head showed multiple enhancing lesions with significant surrounding oedema in both cerebral hemispheres. Read More

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http://casereports.bmj.com/lookup/doi/10.1136/bcr-2018-22659
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http://dx.doi.org/10.1136/bcr-2018-226590DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6254463PMC
November 2018
19 Reads

Perfusion magnetic resonance imaging in differentiation of neurocysticercosis and tuberculoma.

Neuroradiology 2019 Mar 30;61(3):257-263. Epub 2018 Oct 30.

Department of Pediatrics, Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, India.

Purpose: Tuberculoma and neurocysticercosis (NCC) are two of the most common intracranial infections in developing countries and cause of seizures or focal neurological deficit. They often present on neuroimaging as ring-enhancing lesions, and in absence of typical imaging features, can cause significant diagnostic dilemma. Differentiation is extremely important to avoid empirical exposure to anti-tubercular treatment or nonspecific treatment causing disease progression. Read More

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http://link.springer.com/10.1007/s00234-018-2118-x
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http://dx.doi.org/10.1007/s00234-018-2118-xDOI Listing
March 2019
21 Reads
2.485 Impact Factor

A case report of isolated distal upper extremity weakness due to cerebral metastasis involving the hand knob area.

BMC Cancer 2018 Oct 3;18(1):947. Epub 2018 Oct 3.

Department of Neurology, Semmelweis University, Balassa u. 6., H- 1083, Budapest, Hungary.

Background: Unilateral weakness of an upper extremity is most frequently caused by traumatic nerve injury or compression neuropathy. In rare cases, lesion of the central nervous system may result in syndromes suggesting peripheral nerve damage by the initial examination. Pseudoperipheral hand palsy is the best known of these, most frequently caused by a small lesion in the contralateral motor cortex of the brain. Read More

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https://bmccancer.biomedcentral.com/articles/10.1186/s12885-
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http://dx.doi.org/10.1186/s12885-018-4857-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6171188PMC
October 2018
9 Reads

Tuberculosis of the Central Nervous System.

Authors:
Joseph R Zunt

Continuum (Minneap Minn) 2018 10;24(5, Neuroinfectious Disease):1422-1438

Purpose Of Review: This article details the epidemiology and clinical manifestations of central nervous system (CNS) tuberculosis (TB), provides guidance for diagnostic imaging and CSF testing, and recommends treatment strategies for tuberculous meningitis and other forms of CNS TB, illustrating key aspects of diagnosis and management with case presentations.

Recent Findings: Although improvements in our understanding of the pathogenesis and management of CNS TB have occurred over the past 50 years, the emergence of multidrug-resistant and extensively drug-resistant TB, the advent of acquired immunodeficiency syndrome (AIDS), and the subsequent availability of highly active antiretroviral therapy that can produce the immune reconstitution inflammatory syndrome have complicated the diagnosis and treatment of CNS TB. Advances in diagnostic assays promise to increase the speed of diagnosis as well as the percentage of people with a confirmed rather than a presumptive diagnosis. Read More

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http://dx.doi.org/10.1212/CON.0000000000000648DOI Listing
October 2018
2 Reads

Validation of Mycobacterium tuberculosis real-time polymerase chain reaction for diagnosis of tuberculous meningitis using cerebrospinal fluid samples: a pilot study.

Clin Chem Lab Med 2019 Mar;57(4):556-564

Bacteriology Laboratory, Hospital de Clinicas, Universidade Federal do Paraná, Curitiba, Paraná, Brazil.

Background Timely diagnosis of tuberculous meningitis (TBM) remains challenging. Molecular diagnostic tools are necessary, particularly in low- and middle-income countries. There is no approved commercial polymerase chain reaction (PCR) assay that can be used to detect Mycobacterium tuberculosis in non-respiratory samples, such as the cerebrospinal fluid (CSF). Read More

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http://www.degruyter.com/view/j/cclm.ahead-of-print/cclm-201
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http://dx.doi.org/10.1515/cclm-2018-0524DOI Listing
March 2019
8 Reads

Central nervous system tuberculosis following delayed and initially missed lung miliary tuberculosis: a case report.

Infez Med 2018 Sep;26(3):270-275

Internal Medicine Master of Medicine, Chiclayo, Lambayeque, Peru; Emergency Department of Regional Hospital of Lambayeque, Chiclayo, Lambayeque, Peru.

Central nervous system (CNS) tuberculosis includes three clinical entities: tuberculous meningitis, intracranial tuberculoma, and spinal tuberculous arachnoiditis. All three categories are encountered frequently in regions of the world where the incidence of TB is high. Meningeal tuberculosis is a medical emergency: it is the most severe, lethal and disabling form of tuberculosis. Read More

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September 2018
5 Reads

Central Nervous System Tuberculosis : Etiology, Clinical Manifestations and Neuroradiological Features.

Clin Neuroradiol 2019 Mar 17;29(1):3-18. Epub 2018 Sep 17.

Department of Neurology, Sankt Katharinen Hospital, Teaching Hospital, Goethe University, Frankfurt, Germany.

Purpose: As a result of multilateral migration and globalization in times of humanitarian crises, western countries face a possible increase in the incidence of central nervous system tuberculosis (CNS TB). The diagnosis of CNS TB is challenging and often delayed due to the manifold and often non-specific presentation of the disease. The aim of this review is to analyze and summarize imaging features and correlated clinical findings of CNS TB. Read More

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http://dx.doi.org/10.1007/s00062-018-0726-9DOI Listing
March 2019
4 Reads

The Imaging of Localization Related Symptomatic Epilepsies: The Value of Arterial Spin Labelling Based Magnetic Resonance Perfusion.

Korean J Radiol 2018 Sep-Oct;19(5):965-977. Epub 2018 Aug 6.

Department of Imaging Sciences & Interventional Radiology, Sree Chitra Tirunal Institute for Medical Sciences & Technology (SCTIMST), Trivandrum 695011, India.

Accurate identification of the epileptogenic zone is an important prerequisite in presurgical evaluation of refractory epilepsy since it affects seizure-free outcomes. Apart from structural magnetic resonance imaging (sMRI), delineation has been traditionally done with electroencephalography and nuclear imaging modalities. Arterial spin labelling (ASL) sequence is a non-contrast magnetic resonance perfusion technique capable of providing similar information. Read More

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http://dx.doi.org/10.3348/kjr.2018.19.5.965DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6082755PMC
April 2019
6 Reads

Isolated Oculomotor and Abducens Nerve Palsies as Initial Presentation of Cavernous Sinus Tuberculoma: Case Report and Literature Review.

World Neurosurg 2018 Sep 2;117:413-418. Epub 2018 Jul 2.

Department of Neurology, Tehran Medical Sciences Branch, Islamic Azad University, Tehran, Iran. Electronic address:

Background: Central nervous system tuberculoma is the most severe manifestation of extrapulmonary tuberculosis with high mortality. Cavernous sinus tuberculoma (CST) is a very rare central nervous system tuberculoma with few cases reported in the literature.

Case Description: A 57-year-old woman was admitted to our clinic with acute diplopia and headache limited to the right side. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S18788750183141
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http://dx.doi.org/10.1016/j.wneu.2018.06.203DOI Listing
September 2018
22 Reads

Diffuse large B-cell lymphoma with pulmonary and cerebral involvement: A case report.

Mol Clin Oncol 2018 Sep 16;9(3):264-268. Epub 2018 Jul 16.

Department of Infectious Diseases, Capital Medical University Affiliated Beijing You An Hospital, Beijing 100069, P.R. China.

Primary diffuse large B-cell lymphoma (DLBCL) is the most common type of non-Hodgkin lymphoma; however, the involvement of the lung and central nervous system (CNS) in patients with DLBCL is rare. Furthermore, patients with DLBCL rarely exhibit specific clinical symptoms, which may delay definitive diagnosis. The present study reports the case of a 42-year-old man suffering from primary DLBCL with concurrent pulmonary and cerebral involvement. Read More

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http://dx.doi.org/10.3892/mco.2018.1673DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6109671PMC
September 2018
10 Reads

Isolated Tuberculoma Mimicking Foramen Magnum Meningioma in the Absence of Primary Tuberculosis: A Case Report.

Neurospine 2018 Sep 28;15(3):277-282. Epub 2018 Aug 28.

Department of Neurosurgery, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.

Central nervous system tuberculosis is a devastating complication of systemic tuberculosis. Intradural extramedullary (IDEM) tuberculoma at the foramen magnum is rare, and mimics en plaque meningioma. We report the case of a 53-year-old woman who presented with dysesthesia of the tongue and lower cranial nerve (CN) palsy, with onset 4 months prior to admission. Read More

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http://e-neurospine.org/journal/view.php?doi=10.14245/ns.183
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http://dx.doi.org/10.14245/ns.1836034.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6226133PMC
September 2018
20 Reads

Delayed Diagnosis of Tuberculoma in a Child with Nephritis due to Systemic Lupus Erythematosus.

Turk Thorac J 2018 Jul 19;19(3):153-155. Epub 2018 Jun 19.

Department of Child Health, Padjadjaran University School of Medicine, Hasan Sadikin General Hospital, Bandung, Indonesia.

Tuberculoma is one of the manifestations of tuberculosis infection in the central nervous system. Even though its prevalence is only 1%, the mortality rate is high. Clinical presentation in immunocompromised patients with tuberculoma maybe different, thus making the diagnosis difficult. Read More

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http://dx.doi.org/10.5152/TurkThoracJ.2018.17033DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6077006PMC
July 2018
23 Reads

Intracranial tuberculous mass lesions treated with thalidomide in an immunocompetent child from a low tuberculosis endemic country: A case report.

Medicine (Baltimore) 2018 Jul;97(29):e11186

Department of Public Health and Infectious Diseases, Sapienza University of Rome, Rome.

Rationale: Tuberculous meningitis is a highly morbid, often fatal disease.

Patient Concern: We describe a case of an Italian child. DIAGNOSES:: we diagnosed early a Tuberculous meningitis complicated by the occurrence of hydrocephalus, stroke, and paradoxical reaction with brain pseudo-abscesses. Read More

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http://dx.doi.org/10.1097/MD.0000000000011186DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6086519PMC
July 2018
6 Reads

Evaluation of intracranial tuberculomas using diffusion-weighted imaging (DWI), magnetic resonance spectroscopy (MRS) and susceptibility weighted imaging (SWI).

Br J Radiol 2018 Nov 23;91(1091):20180342. Epub 2018 Jul 23.

1 Department of Radiodiagnosis, Sher-i-Kashmir Institute of Medical Sciences , Srinagar , India.

Objective:: The present study was aimed to evaluate patients of suspected intracranial tuberculomas with diffusion-weighted imaging (DWI), magnetic resonance spectroscopy (MRS) and susceptibility-weighted imaging (SWI).

Methods:: The present study evaluated 116 patients known or suspected of having central nervous system tuberculosis with advanced MRI techniques comprising of DWI, MRS and SWI in addition to the conventional MRI.

Results:: Apparent diffusion coefficient value of tuberculomas was not significantly different (p > 0. Read More

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http://dx.doi.org/10.1259/bjr.20180342DOI Listing
November 2018
10 Reads

Late-onset paradoxical reactions 10 years after treatment for tuberculous meningitis in an HIV-negative patient: a case report.

BMC Infect Dis 2018 07 6;18(1):313. Epub 2018 Jul 6.

Department of Neurology, Tsuchiura Kyodo General Hospital, 4-1-1Otsuno, Tsuchiura-shi, Ibaraki, 300-0028, Japan.

Background: Although paradoxical reactions (PRs) to anti-tuberculosis (anti-TB) therapy during treatment are well-established occurrences, PRs presenting as a new lesion after the completion of treatment are extremely rare, and little is known about the management of such cases, particularly of central nervous system (CNS) tuberculosis.

Case Presentation: A 27-year-old female, with a past medical history of tuberculous meningitis 10 years ago and who completed the anti-TB treatment with asymptomatic remnant tuberculomas in the basal cistern, was admitted to our hospital because of a headache and the worsening of pre-existing visual disturbance. Contrast-enhanced T1-weighted brain magnetic resonance imaging (MRI) revealed new tuberculomas in the left sylvian fissure with a diffuse low signal around it. Read More

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http://dx.doi.org/10.1186/s12879-018-3229-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6035426PMC
July 2018
4 Reads

Multiple tuberculomas invading the central nervous system as a paradoxical reaction in a kidney transplantation recipient.

Saudi J Kidney Dis Transpl 2018 May-Jun;29(3):719-722

Department of Internal Medicine, Keimyung University School of Medicine, Keimyung University Kidney Institution, Daegu, Korea.

A paradoxical reaction during anti-tuberculosis (anti-TB) therapy is commonly reported in patients with human immunodeficiency virus (HIV). However, a similar reaction to anti-TB therapy can also occur in patients without HIV, especially in patients who have undergone solid organ transplantation. A 65-year-old woman who underwent kidney transplantation six months prior presented to our emergency room with progressive paraparesis. Read More

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http://dx.doi.org/10.4103/1319-2442.235190DOI Listing
July 2018
20 Reads

Multifocal Brain Lesions With Extensive Perilesional Edema in a Young Boy Returning From Kenya.

Semin Pediatr Neurol 2018 07 1;26:132-134. Epub 2017 Apr 1.

Division of Child Neurology, Nationwide Children's Hospital, Columbus, OH.

We report the case of an 8-year-old boy who presented with headaches, optic disc edema, and left eye esotropia. He had recently returned to the United States after living in Kenya for approximately 3 years. His brain magnetic resonance imaging showed multifocal lesions with significant perilesional edema seemingly out of proportion to his neurologic examination findings. Read More

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http://dx.doi.org/10.1016/j.spen.2017.03.021DOI Listing

Weber syndrome secondary to brain stem tuberculoma.

Indian J Ophthalmol 2018 07;66(7):1036-1039

Department of Radiodiagnosis, All India Institute of Medical Sciences, Bhubaneswar, Odisha, India.

This case report describes a rare presentation of presumed brain stem tuberculoma in a 28-year-old male who presented with acute onset of third cranial nerve palsy with contralateral hemiparesis (Weber syndrome) and upgaze palsy. Isolated midbrain tuberculoma is rare, presenting with varied clinical manifestations and radiological findings posing as a diagnostic dilemma. Weber syndrome is commonly caused by midbrain infarct secondary to occlusion of branches of the posterior cerebral artery and rarely from a tuberculoma. Read More

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http://dx.doi.org/10.4103/ijo.IJO_1040_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6032746PMC
July 2018
12 Reads

[Cerebral tuberculosis without meningitis in a immunocompetent child].

Rev Chilena Infectol 2018 04;35(2):207-212

Clínica Las Américas, Medellín, Colombia.

Cerebral tuberculosis TB (tuberculomas) without meningitis is an uncommon disease with a high morbidity and mortality. We report on a case that illustrates the complexity of this clinical presentation. An 11 month old, previously healthy male infant was brought to the clinic due to fever present during the last 1. Read More

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http://dx.doi.org/10.4067/s0716-10182018000200207DOI Listing
April 2018
14 Reads

Paradoxical Reaction in a Patient with Co-Occurring Tuberculous Meningitis and Pott's Disease.

Am J Case Rep 2018 Jun 16;19:699-704. Epub 2018 Jun 16.

Department of Internal Medicine, Section of Infectious Disease, Yale University School of Medicine, New Haven, CT, USA.

BACKGROUND Paradoxical reactions to tuberculosis (TB) are clinical or radiological worsening of prior tuberculous lesions or the development of new lesions upon treatment with appropriate anti-tuberculosis therapy (ATT). This phenomenon has been described in both HIV-seropositive and HIV-seronegative patients. Although historically estimated to occur in 6-30% of HIV-seronegative patients with TB, the phenomenon is often under-recognized in the current era, particularly in countries of low TB prevalence. Read More

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http://dx.doi.org/10.12659/AJCR.909194DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6034555PMC
June 2018
2 Reads

Central nervous system blast crisis of chronic myeloid leukaemia misdiagnosed as tubercular meningitis.

BMJ Case Rep 2018 Jun 12;2018. Epub 2018 Jun 12.

Department of Neurology, Sawai Mansingh Medical College and Hospital, Jaipur, Rajasthan, India.

Chronic Myeloid Leukaemia (CML) presenting with isolated Central Nervous System (CNS) blast crisis is an uncommon entity. A 22-year-old man, diagnosed with chronic phase CML in 2011 and was in haematological and cytogenetic remission until July 2016, had acute onset headache and vomiting with meningeal signs and was admitted elsewhere, investigated by brain imaging and cerebrospinal fluid (CSF) analysis and suspected to have tubercular meningitis, for which steroids and antitubercular medications were started. The patient's sensorium further deteriorated, and Ventriculoperitoneal shunt surgery was done for hydrocephalus by a neurosurgeon. Read More

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http://dx.doi.org/10.1136/bcr-2017-223923DOI Listing
June 2018
4 Reads

Unusual case of cerebral demyelination and bilateral optic neuritis in an infant with suppurative BCG lymphadenitis.

BMJ Case Rep 2018 May 30;2018. Epub 2018 May 30.

Paediatric Neurology, Hospital Kuala Lumpur, Kuala Lumpur, Malaysia.

Cerebral demyelination and optic neuritis are often seen in children with acute disseminated encephalomyelitis following various infections and immunisations. An eight month old girl presented with a left axillary lymph node swelling and an erythematous lace-like rash over her cheeks and trunk. She then developed acute encephalopathy, bilateral nystagmus, right hemiparesis and left facial nerve palsy. Read More

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http://casereports.bmj.com/lookup/doi/10.1136/bcr-2018-22449
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http://dx.doi.org/10.1136/bcr-2018-224496DOI Listing
May 2018
13 Reads

Role of Immuno-Polymerase Chain Reaction (I-PCR) in Resolving Diagnostic Dilemma Between Tuberculoma and Neurocysticercosis: A Case Report.

Am J Case Rep 2018 May 24;19:599-603. Epub 2018 May 24.

Centre for Biotechnology, Maharshi Dayanand University (MDU), Rohtak, Haryana, India.

BACKGROUND Tuberculoma and neurocysticercosis (NCC) often show similar clinical and neuroimaging features. Differential diagnosis of these 2 diseases is imperative, as tuberculoma is an active infection that requires immediate anti-tubercular therapy (ATT). CASE REPORT We present the case of a 17-year-old Indian girl with fever, severe headache, and right 6th cranial nerve palsy. Read More

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http://dx.doi.org/10.12659/AJCR.908624DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5994961PMC
May 2018
7 Reads

Enhanced brain penetration of pretomanid by intranasal administration of an oil-in-water nanoemulsion.

Nanomedicine (Lond) 2018 05 23;13(9):997-1008. Epub 2018 May 23.

Catalysis & Peptide Research Unit, School of Health Sciences, University of KwaZulu-Natal, Westville Campus, Durban 4000, South Africa.

Aim: To enhance the drug delivery to the brain with an oil-in-water nanoemulsion of pretomanid via intranasal (IN) administration.

Materials & Methods: The study involved 70 male Sprague-Dawley rats (160-180 g) that received either 20 mg/kg body weight (b.w. Read More

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http://dx.doi.org/10.2217/nnm-2017-0365DOI Listing
May 2018
5 Reads
5.413 Impact Factor

Behçet's Syndrome and Nervous System Involvement.

Curr Neurol Neurosci Rep 2018 May 23;18(7):35. Epub 2018 May 23.

Cerrahpaşa School of Medicine, Department of Neurology, Istanbul University, Istanbul, Turkey.

Purpose Of Review: Although Behçet's syndrome (BS) is classified as a rare disease in European countries and the USA, its neurologic involvement "neuro-Behçet's syndrome (NBS)" is commonly included in the differential diagnosis of many inflammatory and vascular central nervous system (CNS) disorders. Clinical and neuroimaging findings support two major forms of NBS: parenchymal NBS (p-NBS) and an extra-parenchymal form that presents with cerebral venous sinus thrombosis (CVST). The present review summarizes recent findings on the etiopathogenesis and clinico-radiological features of this disorder as well as its treatment options. Read More

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http://dx.doi.org/10.1007/s11910-018-0843-5DOI Listing
May 2018
12 Reads

Management of Pediatric Posterior Circulation Aneurysms-12-Year Single-Institution Experience.

World Neurosurg 2018 Aug 17;116:e624-e633. Epub 2018 May 17.

Department of Neurosurgery, All India Institute of Medical Sciences, New Delhi, India.

Background: Pediatric posterior circulation aneurysms are rare, complex, poorly understood lesions on which only limited literature is currently available. We report our 12-year experience of managing this condition to enhance knowledge of this rare entity.

Methods: Patients <18 years old with posterior circulation aneurysms managed at our institution from January 2005 to April 2017 were included. Read More

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http://dx.doi.org/10.1016/j.wneu.2018.05.056DOI Listing
August 2018
5 Reads

The first case of bacillus Calmette-Guérin-induced small-vessel central nervous system vasculitis.

Clin Rheumatol 2018 Aug 9;37(8):2297-2302. Epub 2018 May 9.

Department of Rheumatology, Centre Intégré Universitaire de Santé et de Services Sociaux de l'Estrie, Centre Hospitalier Universitaire de Sherbrooke, 3001 12e Avenue Nord, Sherbrooke, QC, J1H 5N4, Canada.

To present an unrecognized vascular complication of bacillus Calmette-Guérin (BCG) therapy administered for superficial bladder carcinoma. We also review the potential mimickers for primary angiitis of the central nervous system (PACNS) as well as complications of intravesical BCG therapy. An 89-year-old Caucasian man with a history of relapsing high-grade bladder carcinoma treated with intravesical BCG presented with recurring episodes of right upper limb paresthesia with clumsiness and dysarthria. Read More

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http://link.springer.com/10.1007/s10067-018-4136-9
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http://dx.doi.org/10.1007/s10067-018-4136-9DOI Listing
August 2018
15 Reads
1.770 Impact Factor

Cyclophosphamide immunomodulation of TB-associated cerebral vasculitis.

Infect Dis (Lond) 2018 10 28;50(10):779-782. Epub 2018 Apr 28.

a Tropical and Infectious Diseases Unit Department , Padua University Hospital , Padua , Italy.

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http://dx.doi.org/10.1080/23744235.2018.1467038DOI Listing
October 2018
3 Reads

Use of Linezolid in a Child With Tuberculous Meningitis.

Pediatr Infect Dis J 2018 05;37(5):499

Department of Pediatrics, Infectious Diseases Unit, Regina Margherita Children's Hospital, University of Turin, Italy Child and Adolescent Neurology and Psychiatry Division, Regina Margherita Children's Hospital, University of Turin, Italy Department of Pediatric Neurosurgery, Regina Margherita Children's Hospital, University of Turin, Italy Department of Pediatrics, Infectious Diseases Unit, Regina Margherita Children's Hospital, University of Turin, Italy.

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http://dx.doi.org/10.1097/INF.0000000000001801DOI Listing
May 2018
1 Read

[Optochiasmatic tuberculomas as a paradoxical reaction to treatment for meningeal tuberculosis].

Rev Neurol 2018 Apr;66(8):286-288

Hospital de Especialidades Centro Medico Nacional Siglo XXI. IMSS, Mexico DF, Mexico.

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April 2018
2 Reads

Hypovolemia due to cerebral salt wasting may contribute to stroke in tuberculous meningitis.

QJM 2018 Jul;111(7):455-460

Department of Radiology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow 226014, India.

Background: Both stroke and cerebral salt wasting (CSW) are common in tuberculous meningitis (TBM), but there is paucity of studies evaluating their combined effect.

Aim: The present study has been undertaken to evaluate the spectrum of stroke in TBM and its relation to CSW.

Design: Hospital-based prospective cohort study. Read More

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http://dx.doi.org/10.1093/qjmed/hcy072DOI Listing
July 2018
2 Reads

Chiari malformation and tuberculous meningitis: aetiology and management.

BMJ Case Rep 2018 Apr 5;2018. Epub 2018 Apr 5.

Department of Neurosciences, University of the Philippines-Philippine General Hospital, Manila, Philippines.

This is the first reported case of a Chiari 1 malformation in association with tuberculous (TB) meningitis. We present a case of a 23-year-old woman with a 2-week history nocturnal fever, vertigo, headache and projectile vomiting. She had nystagmus, scanning speech, bilateral papilloedema and ataxia. Read More

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http://dx.doi.org/10.1136/bcr-2018-224245DOI Listing
April 2018
23 Reads

[A case of histoplasmosis with chronic basilar meningitis diagnosed relatively early].

Rinsho Shinkeigaku 2018 Apr 31;58(4):241-244. Epub 2018 Mar 31.

Department of Neurology, The Jikei University Kashiwa Hospital.

A 41-year-old man left for Mexico in May 2015. Right pulmonary nodule was detected at a health examination in May 2016, and he subsequently showed headache and slight fever. Contrast-enhanced magnetic resonance imaging of the brain revealed basilar meningitis, so he was admitted to our hospital. Read More

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https://www.jstage.jst.go.jp/article/clinicalneurol/58/4/58_
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http://dx.doi.org/10.5692/clinicalneurol.cn-001136DOI Listing
April 2018
5 Reads

Acute brainstem compression.

BMJ Case Rep 2018 Mar 30;2018. Epub 2018 Mar 30.

Neurosurgery, Universita Cattolica del Sacro Cuore Sede di Roma, Rome, Italy.

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http://dx.doi.org/10.1136/bcr-2018-224706DOI Listing
March 2018
2 Reads

Unique case of midbrain tuberculoma presenting as isolated inferior rectus palsy with nystagmus.

Indian J Ophthalmol 2018 04;66(4):599-602

Department of Neuro Ophthalmology, Aravind Eye Hospitals and Postgraduate Institute of Ophthalmology, Madurai, Tamil Nadu, India.

Isolated brain stem tuberculoma constitutes about 5% of all intracranial tuberculomas. A case of isolated inferior rectus palsy with downbeat nystagmus due to presumed midbrain tuberculoma in an immunocompetent patient is described here. This report documents a rare entity of a combination of partial third nerve palsy with pupil involvement along with downbeat nystagmus. Read More

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http://dx.doi.org/10.4103/ijo.IJO_470_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5892078PMC
April 2018
6 Reads

Progress on Diagnosis of Tuberculous Meningitis.

Methods Mol Biol 2018 ;1754:375-386

Department of Neurology, Tianjin Medical University General Hospital, Tianjin, P.R. China.

Central nervous system (CNS) disease caused by Mycobacterium tuberculosis (MTB) is highly devastating. Tuberculous meningitis (TBM) is the most common form of CNS tuberculosis (TB). Rapid, sensitive, and affordable diagnostic tests are not available. Read More

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http://dx.doi.org/10.1007/978-1-4939-7717-8_20DOI Listing
January 2019
22 Reads

A 27-Year-Old Female with Multiple Intracranial Lesions.

Brain Pathol 2018 03;28(2):303-305

Department of Neurosurgery, Ibn Alhaytham Hospital, Amman, Jordan.

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http://dx.doi.org/10.1111/bpa.12590DOI Listing
March 2018
4 Reads

Diagnosis of Chronic Leptomeningitis by Using Meningeal Biopsy: A Case Report of Tuberculous Meningitis.

Acta Neurol Taiwan 2017 Sep;26(3):133-137

Department of Neurology, Shuang Ho Hospital, Taipei Medical University, New Taipei City, Taiwan.

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September 2017

[A pregnant woman with headache and fever].

Tidsskr Nor Laegeforen 2018 02 19;138(4). Epub 2018 Feb 19.

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http://dx.doi.org/10.4045/tidsskr.17.0383DOI Listing
February 2018
2 Reads

Facial Weakness, Diplopia, and Fever in a 31-Year-Old: An Atypical Case of Tuberculous Meningitis.

Cureus 2017 Dec 7;9(12):e1918. Epub 2017 Dec 7.

Department of Medicine, Northwell Long Island Jewish Medical Center, New York, United States.

Tuberculous meningitis (TBM) is an infection of the central nervous system (CNS) meninges that carries high morbidity and mortality. It is important to recognize, as patients may present with atypical symptoms. We describe the case of a 31-year-old man with a history of diabetes who presented with a sub-acute onset of right-sided facial weakness and right gaze difficulty with diplopia. Read More

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http://dx.doi.org/10.7759/cureus.1918DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5802756PMC
December 2017
5 Reads