1,750 results match your criteria Imaging in CNS Tuberculosis


Wiad Lek 2021 ;74(5):1274-1276


Objective: The aim: To pay attention of clinicians to possible lesions of the central nervous system (encephalitis) in patients with COVID-19.

Patients And Methods: Case presentation: A 44-year-old woman was admitted to our clinic because of 2-month-history of mild fever, bilateral lower lobe pneumonia, respiratory failure, generalized weakness, and some neurologic symptoms. SARS-CoV-2 RNA was detected in nasopharyngeal swab. Read More

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Acquired unilateral upper limb hypertrophy as a late complication of tuberculous meningitis complicated by Chiari 1 malformation and syringomyelia.

BMJ Case Rep 2021 May 25;14(5). Epub 2021 May 25.

Paediatrics and Child Health, Stellenbosch University Faculty of Medicine and Health Sciences, Cape Town, Western Cape, South Africa.

Syringomyelia associated with tuberculous meningitis (TBM) is an extremely rare condition. Only a few adult cases have been reported. A 12-year-old woman, who previously suffered TBM at the age of 6 months, presented with a long-standing history of right upper limb panhypertrophy, dissociate anaesthesia, frequent headaches, scoliosis and acquired macrocephaly. Read More

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Extrapulmonary tuberculosis.

Expert Rev Respir Med 2021 May 8. Epub 2021 May 8.

Department of Epidemiology and Biostatistics and Occupational Health, McGill International TB Centre, McGill University, Canada.

: Tuberculosis (TB) is a major cause of morbidity and mortality globally. Extrapulmonary TB (EPTB) constitutes about 15%-20% of all TB patients but accounts for 50% among HIV-coinfected. Confirmation of microbial diagnosis of EPTB is usually challenging. Read More

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Recurrent tuberculous cerebellar abscess: A case study and review of the literature.

Int J Surg Case Rep 2021 Apr 26;81:105832. Epub 2021 Mar 26.

Neurosurgery Department, Fann University Hospital Center, Dakar, Senegal.

Introduction And Importance: Tuberculous cerebellar abscess is a rare form of extra-pulmonary tuberculosis. The outcome is often favorable with well-managed treatment; however, they can continue to develop. We share in this article our experience on the management of this rare pathologie. Read More

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Encephalitis due to miliary tuberculosis in a patient with human immunodeficiency virus: A case report.

J Clin Tuberc Other Mycobact Dis 2021 May 19;23:100230. Epub 2021 Mar 19.

Duta Wacana Christian University School of Medicine, Yogyakarta, Indonesia.

Background: Miliary tuberculosis (TB) is a form of extrapulmonary tuberculosis due to hematogenous dissemination and occurs more frequently in immunocompromised patients. Clinical manifestations are non-specific and varied with the related organ, including central nervous system involvement. We report the first case of encephalitis associated with miliary TB in human immunodeficiency virus (HIV)-the infected patient. Read More

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Clinical and radiological aspects of bilateral temporal abnormalities: pictorial essay.

Radiol Bras 2021 Mar-Apr;54(2):115-122

Universidade Estadual de Campinas (Unicamp), Campinas, SP, Brazil.

The temporal lobes are vulnerable to several diseases, including infectious, immune-mediated, degenerative, vascular, metabolic, and neoplastic processes. Therefore, lesions in the temporal lobes can pose a diagnostic challenge for the radiologist. The temporal lobes are connected by structures such as the anterior commissure, corpus callosum, and hippocampal commissure. Read More

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Applicability of High-Frequency Ultrasound to the Early Diagnosis of Diabetic Peripheral Neuropathy.

Biomed Res Int 2021 18;2021:5529063. Epub 2021 Mar 18.

Department of Ultrasound, Qingdao Municipal Hospital, Qingdao, Shandong 266071, China.

This study investigated the applicability of high-frequency ultrasound (HFU) to the early diagnosis of diabetic peripheral neuropathy (DPN). Patients with type 2 diabetes ( = 60) were divided into diabetic nonperipheral neuropathy and DPN groups (group A and group B, respectively; = 30 each) based on electroneurophysiologic findings. Additionally, 30 nondiabetic patients were included as the healthy control group (group C). Read More

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Cerebrospinal Fluid Analysis.

Am Fam Physician 2021 04;103(7):422-428

Womack Army Medical Center, Fort Bragg, NC, USA.

Cerebrospinal fluid (CSF) analysis is a diagnostic tool for many conditions affecting the central nervous system. Urgent indications for lumbar puncture include suspected central nervous system infection or subarachnoid hemorrhage. CSF analysis is not necessarily diagnostic but can be useful in the evaluation of other neurologic conditions, such as spontaneous intracranial hypotension, idiopathic intracranial hypertension, multiple sclerosis, Guillain-Barré syndrome, and malignancy. Read More

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Calcified intracranial tuberculomas as sequelae of pediatric neurotuberculosis.

Arq Neuropsiquiatr 2021 02;79(2):178

Universidade de São Paulo, Faculdade de Medicina, Departamento de Radiologia e Oncologia, São Paulo SP, Brazil.

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February 2021

Neuroradiology of infectious diseases.

Curr Opin Infect Dis 2021 Jun;34(3):228-237

Section of Infectious Diseases, UT Health McGovern Medical School, Houston, Texas, USA.

Purpose Of Review: Early diagnosis of central nervous system (CNS) infections is crucial given high morbidity and mortality. Neuroimaging in CNS infections is widely used to aid in the diagnosis, treatment and to assess the response to antibiotic and neurosurgical interventions.

Recent Findings: The Infectious Diseases Society of America (IDSA) guidelines have clear recommendations for obtaining a computerized tomography of the head (CTH) prior to lumbar puncture (LP) in suspected meningitis. Read More

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Meningeal tuberculoma: when to consider it?

Rev Soc Bras Med Trop 2021;54. Epub 2021 Mar 8.

Universidade Federal de Pernambuco, Centro de Ciências Médicas, Recife, PE, Brasil.

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Neurological issues during severe COVID-19 in a tertiary level hospital in Western India.

Neurosci Lett 2021 04 13;749:135692. Epub 2021 Feb 13.

Department of Medicine, Noble Hospital and Research Centre, Pune, Maharashtra, India.

Background: India has the second largest COVID-19 epidemic in the world as per current estimates. Central and peripheral nervous system involvement in COVID-19 (Neuro COVID-19) has been increasingly identified and reported. This letter is the first report of the spectrum of neurological disorders observed in patients with severe COVID-19 from a resource limited setting like India. Read More

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Giant Tuberculomas of Brain: Rare Neoplastic Mimic.

J Pediatr Neurosci 2020 Jul-Sep;15(3):204-213. Epub 2020 Nov 6.

Department of Radiodiagnosis, Sanjay Gandhi Postgraduate Institute of Medical Sciences (SGPGI), Lucknow, Uttar Pradesh, India.

Objective: Tuberculosis continues to be a major infectious disease in developing parts of the world. Primarily central nervous system tuberculosis manifests as meningitis, tuberculoma, or a brain abscess; however, rarely it may manifest as a large neoplastic mass such as lesion known as giant tuberculoma. Especially in central parts of India, the incidence of giant tuberculoma is quite high in pediatric population that too in posterior fossa of brain. Read More

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November 2020

Is cerebral salt wasting related to sympathetic dysregulation in tuberculous meningitis?

Neurosci Lett 2021 03 29;747:135671. Epub 2021 Jan 29.

Department of Neurology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, India. Electronic address:

Background: Cerebral Salt wasting (CSW) is common in Tuberculous Meningitis (TBM) and is suggested to be due to sympathetic dysregulation of renal blood supply but has not been proven.

Objective: To evaluate plasma Catecholamines in TBM patients with CSW and correlate with the markers of stress.

Materials And Methods: The diagnosis of TBM was based on clinical, CSF and MRI criteria. Read More

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Case 1-2021: A 76-Year-Old Woman with Lethargy and Altered Mental Status.

N Engl J Med 2021 Jan;384(2):166-176

From the Departments of Medicine (L.M.B., A.K.B.), Radiology (R.G.G.), and Pathology (M.N.A.), Massachusetts General Hospital, and the Departments of Medicine (L.M.B., A.K.B.), Radiology (R.G.G.), and Pathology (M.N.A.), Harvard Medical School - both in Boston.

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January 2021

Bilateral ptosis: An unusual presentation of mid brain tuberculoma.

Med J Armed Forces India 2021 Jan 2;77(1):96-100. Epub 2019 Apr 2.

Senior Advisor (Medicine&Oncology), Command Hospital (Air Force), Bengaluru, India.

Central nervous system tuberculoma can have different clinical manifestations like headache, seizures, papilledema or other signs of raised intracranial pressure depending up on the site and number of tuberculoma. We report a case of 56 year old female reported with history of bilateral asymmetric ptosis of one month duration,with no other neurological defecit. Magnetic resonance imaging (MRI) brain revealed well defined ring enhancing lesion in the medial aspect of left hemi midbrain with diffuse disproportionate perilessional edema. Read More

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January 2021

Intramedullary Conus Medullaris Tuberculoma: A Case Report and Review of the Literature.

Infect Dis Rep 2021 Jan 15;13(1):82-88. Epub 2021 Jan 15.

Department of Medicine, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand.

Intramedullary tuberculoma (IMT) of the conus medullaris is extremely rare. We present a case of intramedullary conus medullaris tuberculoma in which the diagnosis was based on there being very high levels of adenosine deaminase (ADA) in the patient's cerebrospinal fluid (CSF) and improvement with antituberculous therapy. A 78-year-old man presented after having had a dull ache in both thighs and progressive paraparesis. Read More

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January 2021

Acute development of syringomyelia following TBM in a pediatric case.

BMC Pediatr 2021 01 14;21(1):36. Epub 2021 Jan 14.

Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, Chengdu, China.

Background: Syringomyelia secondary to tuberculous meningitis (TBM) is rarely reported, and is usually a late complication. Acute development of syringomyelia following TBM is an exceedingly rare condition with only a few cases published in adults and no previous reports in children.

Case Presentation: We present a case of syringomyelia as an acute complication of TBM in a 12-year-old boy despite appropriate chemotherapy. Read More

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January 2021

FDG PET/CT in Disseminated Intracranial and Intramedullary Spinal Cord Tuberculomas.

Clin Nucl Med 2021 03;46(3):266-269

Nuclear Medicine, Changhai Hospital, Navy Military Medical University, Shanghai, China.

Abstract: A 54-year-old woman was referred because of dizziness with fatigue for 2 months. MRI of the head and spinal cord revealed multiple ring or homogeneous enhancing nodules in the brain and spinal cord, concerning for metastases. FDG PET/CT showed multiple hypermetabolic nodules in the brain and spinal cord corresponding to the gadolinium-enhanced nodules and diffuse FDG uptake in the bilateral lower lobes of the lungs. Read More

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A woman with disseminated tuberculosis experienced preterm delivery, fallopian tube pregnancy, and delivered successfully following in vitro fertilization: a case report.

BMC Pregnancy Childbirth 2021 Jan 7;21(1):27. Epub 2021 Jan 7.

Department of Reproductive Medicine, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing, 100026, China.

Background: Disseminated tuberculosis (TB) is a fatal disease resulting from hematogenous dissemination of Mycobacterium tuberculosis. Spontaneous pregnancy rate of women with TB is low; furthermore, live birth, spontaneous abortion or ectopic pregnancy may be the outcomes even if pregnancy occurs.

Case Presentation: We report a case of a woman with disseminated TB who had a series of complications including preterm delivery with congenital TB and infant death of pulmonary TB, fallopian tube pregnancy. Read More

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January 2021

Paraplegia from spinal intramedullary tuberculosis: A case report.

World J Clin Cases 2020 Dec;8(24):6353-6357

Department of Neurosurgery, The First Hospital of Jilin University, Changchun 130021, Jilin Province, China.

Background: Tuberculosis (TB) mostly attacks the lungs, and extrapulmonary TB involving the central nervous system is uncommon; among these cases, spinal intramedullary TB is even more rare. The clinical manifestations of spinal intramedullary TB are similar to those of intramedullary spinal cord tumors. Therefore, it is necessary to make a careful differential diagnosis of spinal intramedullary lesions to achieve the appropriate treatment and favorable prognosis. Read More

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December 2020

Central nervous system tuberculosis.

Sarosh M Katrak

J Neurol Sci 2021 Feb 25;421:117278. Epub 2020 Dec 25.

Prof. Emeritus, Grant Medical College & Sir JJ Group of Hospitals, Emeritus Director, Jaslok Hospital & Research Centre, Mumbai, India. Electronic address:

The purpose of this article is to review the many facets of central nervous system tuberculosis (CNS-TB). The entities described are tuberculous meningitis (TBM) and its complications, spinal cord disorders, tuberculomas and co-infection with the human immune-deficiency virus (HIV). The latter has become a common problem worldwide becoming a more fulminant disease. Read More

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February 2021

Burkitt lymphoma associated with human immunodeficiency virus infection and pulmonary tuberculosis: A case report.

Medicine (Baltimore) 2020 Dec;99(52):e23853

Department of Radiology and Medical Imaging, Academic Emergency Hospital Sibiu, Sibiu, Romania.

Introduction: The association of human immunodeficiency virus (HIV) infection with Burkitt lymphoma is related to the presence of Epstein Barr virus infection and the impact of the HIV antigen on the expansion of B-polyclonal cells. In Southeast Europe, the association is rare, and recognizing this is important in the therapeutic decision to increase patient survival rate. The association of HIV with Burkitt lymphoma and tuberculosis is even more rarely described in the literature. Read More

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December 2020

Diagnostic characteristics of Xpert MTB/RIF assay for the diagnosis of tuberculous meningitis and rifampicin resistance in Southern Brazil.

Arq Neuropsiquiatr 2020 11;78(11):700-707

Universidade Federal do Paraná, Hospital de Clínicas, Laboratório de Bacteriologia, Curitiba PR, Brazil.

Background: The timely diagnosis of tuberculous meningitis (TBM) is challenging. Molecular diagnostic tools are necessary for TBM, particularly in low- and middle-income countries.

Objectives: We aimed to calculate the diagnostics characteristics of Xpert MTB/RIF for the detection of Mycobacterium tuberculosis in the cerebrospinal fluid (CSF) and the frequency of rifampicin (RIF)-resistance in the CSF samples. Read More

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November 2020

Role of cerebrospinal fluid C-reactive protein in tuberculous meningitis.

Int J Mycobacteriol 2020 Oct-Dec;9(4):422-428

Department of Internal Medicine, Unit V, Christian Medical College, Vellore, Tamil Nadu, India.

Background: Tuberculosis (TB) is still a significant health problem worldwide. Central nervous system TB amounts to 10% of all cases of TB. Despite advances in the pharmacological management of TB, the overall outcomes remain poor with significant mortality and morbidity. Read More

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December 2020

Miliary Brain Tuberculomas and Meningitis: Tuberculosis Beyond the Lungs.

Eur J Case Rep Intern Med 2020 14;7(12):001931. Epub 2020 Sep 14.

Internal Medicine Department, Centro Hospitalar Tâmega e Sousa, Penafiel, Portugal.

Tuberculosis remains one of the most common infectious diseases. Miliary presentation is a rare and possibly lethal form, resulting from massive lymphohaematogenous dissemination of bacilli. The authors describe the case of a 47-year-old immunocompetent woman, diagnosed with miliary tuberculosis, with both lung and central nervous system involvement, who showed total recovery after starting anti-tuberculous drugs. Read More

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September 2020

Autoimmune glial fibrillary acidic protein astrocytopathy manifesting as subacute meningoencephalitis with descending myelitis: a case report.

BMC Neurol 2020 Dec 10;20(1):443. Epub 2020 Dec 10.

Department of Neurology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, 100730, China.

Background: Glial fibrillary acidic protein (GFAP) autoimmune astrocytopathy is characterized by GFAP autoantibody positive encephalitis, meningoencephalitis or meningoencephalomyelitis. The initial clinical presentation may be similar to central nervous system infections making early diagnosis challenging.

Case Presentation: A Chinese female patient presented with subacute meningitis with symptoms of headache, vomiting, and fever. Read More

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December 2020

High-Resolution Vessel Wall MRI as a Complementary Investigation for CNS Tuberculosis.

Can J Neurol Sci 2020 Dec 4:1-2. Epub 2020 Dec 4.

Department of Radiology, Faculty of Medical Sciences, State University of Campinas (UNICAMP), Campinas, SP, Brazil.

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December 2020

Rare Presentation of Pneumonitis in the Absence of Neurological Symptoms in an AIDS Patient and Use of Next-Generation Sequencing for Diagnosis.

Eur J Case Rep Intern Med 2020 4;7(11):001862. Epub 2020 Sep 4.

Department of Internal Medicine, Section of Infectious Diseases, University of Illinois College of Medicine, Peoria, Illinois, USA.

is a known cause of encephalitis in human immunodeficiency virus/acquired immunodeficiency syndrome (HIV/AIDS) patients. pneumonitis is a manifestation of extracerebral toxoplasmosis and can be clinically indistinguishable from other opportunistic infections including pneumonia (PJP) and miliary tuberculosis. In this case report, pneumonitis and disseminated toxoplasmosis was diagnosed using next-generation sequencing (NGS) and polymerase chain reaction (PCR) assessment. Read More

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September 2020

Isolated Oculomotor Nerve Palsy - A Rare Initial Manifestation of Tuberculous Meningitis.

J Assoc Physicians India 2020 Nov;68(11):73-74

Junior Resident, Sarojini Naidu Medical College, Agra, Uttar Pradesh.

Tuberculous meningitis (TBM) is a sub-acute / chronic meningitis known for its diverse manifestations which may lead to delayed diagnosis. An isolated oculomotor nerve palsy as an initial presentation of TB meningitis is quite rare. One such case has presented here; A 18 year female presented to us with ptosis of the left eye. Read More

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November 2020