462 results match your criteria Imaging in Bronchopulmonary Dysplasia


Imaging Assessment of Partial Liquid Ventilation in Bronchopulmonary Dysplasia.

Curr Probl Diagn Radiol 2018 Dec 7. Epub 2018 Dec 7.

Department of Radiology, Children's Hospital of Philadelphia, Philadelphia, PA; Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA.

Partial liquid ventilation is proposed as an alternative ventilation strategy to reduce surface tension, increase alveolar recruitment, and decrease inflammation. Studied in acute respiratory distress and other indications, liquid ventilation is being revisited for infants with bronchopulmonary dysplasia. Perfluorooctyl bromide used for liquid ventilation is radiopaque, allowing radiographic visualization of lung liquid ventilation patterns that may provide additional insight into pulmonary pathophysiology. Read More

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http://dx.doi.org/10.1067/j.cpradiol.2018.12.005DOI Listing
December 2018
1 Read

Recent Advances in Pathology: The 2019 Annual Review Issue of the Journal of Pathology.

J Pathol 2019 Feb 8. Epub 2019 Feb 8.

RECAMO, Masaryk Memorial Cancer Institute, Brno, Czech Republic.

In this Annual Review Issue of The Journal of Pathology, we present 15 invited reviews on topical aspects of pathology, ranging from the impacts of the microbiome in human disease through mechanisms of cell death and autophagy to recent advances in immunity and the uses of genomics for understanding, classifying and treating human cancers. Each of the reviews is authored by experts in their fields and our intention is to provide comprehensive updates in specific areas of pathology in which there has been considerable recent progress. Read More

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http://doi.wiley.com/10.1002/path.5255
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http://dx.doi.org/10.1002/path.5255DOI Listing
February 2019
4 Reads

Third Trimester Cerebellar Metabolite Concentrations are Decreased in Very Premature Infants with Structural Brain Injury.

Sci Rep 2019 Feb 4;9(1):1212. Epub 2019 Feb 4.

Developing Brain Research Laboratory, Children's National Health System, Washington, D.C., USA.

Advanced neuroimaging techniques have improved our understanding of microstructural changes in the preterm supratentorial brain as well as the cerebellum and its association with impaired neurodevelopmental outcomes. However, the metabolic interrogation of the developing cerebellum during the early postnatal period after preterm birth remains largely unknown. Our study investigates the relationship between cerebellar neurometabolites measured by proton magnetic spectroscopy (H-MRS) in preterm infants with advancing post-menstrual age (PMA) and brain injury during ex-utero third trimester prior to term equivalent age (TEA). Read More

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http://dx.doi.org/10.1038/s41598-018-37203-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362247PMC
February 2019

LOCAL PULMONARY DRUG DELIVERY IN THE PRETERM RABBIT: FEASIBILITY AND EFFICACY OF DAILY INTRATRACHEAL INJECTIONS.

Am J Physiol Lung Cell Mol Physiol 2019 Jan 24. Epub 2019 Jan 24.

Development and Regeneration, KU Leuven.

Recent clinical trials in newborns have successfully used surfactant as a drug carrier for an active compound, in order to minimize systemic exposure. To investigate the translational potential of surfactant-compound mixtures and other local therapeutics, a relevant animal model is required where intratracheal (IT) administration for maximal local deposition is technically possible and well tolerated. Preterm rabbit pups (born at 28 days of gestation) were exposed to either hyperoxia or normoxia and randomized to receive daily IT surfactant, daily IT saline or no injections for 7 days. Read More

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http://dx.doi.org/10.1152/ajplung.00255.2018DOI Listing
January 2019
1 Read

Advanced pulmonary MRI to quantify alveolar and acinar duct abnormalities: Current status and future clinical applications.

J Magn Reson Imaging 2019 Jan 13. Epub 2019 Jan 13.

Department of Physics and Astronomy, University of Western Ontario, London, Canada.

There are serious clinical gaps in our understanding of chronic lung disease that require novel, sensitive, and noninvasive in vivo measurements of the lung parenchyma to measure disease pathogenesis and progressive changes over time as well as response to treatment. Until recently, our knowledge and appreciation of the tissue changes that accompany lung disease has depended on ex vivo biopsy and concomitant histological and stereological measurements. These measurements have revealed the underlying pathologies that drive lung disease and have provided important observations about airway occlusion, obliteration of the terminal bronchioles and airspace enlargement, or fibrosis and their roles in disease initiation and progression. Read More

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http://doi.wiley.com/10.1002/jmri.26623
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http://dx.doi.org/10.1002/jmri.26623DOI Listing
January 2019
3 Reads

Intraluminal Pulmonary Vein Stenosis in Children: A "New" Lesion.

Anesth Analg 2018 Nov 16. Epub 2018 Nov 16.

From the Department of Anesthesiology, Critical Care and Pain Medicine, Division of Cardiac Anesthesia, Boston Children's Hospital, Boston, Massachusetts.

Pulmonary vein stenosis (PVS) is a rare disorder that leads to progressive narrowing of the extrapulmonary veins. PVS has been reported in both children and adults and in its worse iteration leads to pulmonary hypertension, right ventricular failure, and death. Multiple etiologies of PVS have been described in children and adults. Read More

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http://dx.doi.org/10.1213/ANE.0000000000003924DOI Listing
November 2018
17 Reads

Diagnostic Value of Multi-Slice Spiral Computed Tomography for Bronchial Dysplasia in Premature Infants.

Med Sci Monit 2018 Oct 15;24:7375-7381. Epub 2018 Oct 15.

Neonatal Intensive Care Unit, Women and Children Health Institute Futian, University of South China, Shenzhen, Guangdong, China (mainland).

BACKGROUND The aim of this study was to investigate the diagnostic value of multi-slice spiral computed tomography (MSCT) for bronchial dysplasia in premature infants. MATERIAL AND METHODS A retrospective analysis of 248 premature infants who were highly suspected to have bronchial dysplasia and were admitted to our hospital from 2015 onwards was conducted. We observed bronchus morphologies, sizes, and tissue characteristics using fiberoptic bronchoscopy (FB) as the criterion standard for diagnosis. Read More

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https://www.medscimonit.com/abstract/index/idArt/911749
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http://dx.doi.org/10.12659/MSM.911749DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6198711PMC
October 2018
4 Reads

Quantitative Assessment of Regional Dynamic Airway Collapse in Neonates via Retrospectively Respiratory-Gated H Ultrashort Echo Time MRI.

J Magn Reson Imaging 2019 Mar 25;49(3):659-667. Epub 2018 Sep 25.

Upper Airway Center, Division of Pulmonary Medicine, Cincinnati Children's Hospital, Cincinnati, Ohio, USA.

Background: Neonatal dynamic tracheal collapse (tracheomalacia, TM) is a common and serious comorbidity in infants, particularly those with chronic lung disease of prematurity (bronchopulmonary dysplasia, BPD) or congenital airway or lung-related conditions such as congenital diaphragmatic hernia (CDH), but the underlying pathology, impact on clinical outcomes, and response to therapy are not well understood. There is a pressing clinical need for an accurate, objective, and safe assessment of neonatal TM.

Purpose: To use retrospectively respiratory-gated ultrashort echo-time (UTE) MRI to noninvasively analyze moving tracheal anatomy for regional, quantitative evaluation of dynamic airway collapse in quiet-breathing, nonsedated neonates. Read More

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http://dx.doi.org/10.1002/jmri.26296DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6375762PMC
March 2019
11 Reads

Early breast milk exposure modifies brain connectivity in preterm infants.

Neuroimage 2019 01 18;184:431-439. Epub 2018 Sep 18.

MRC Centre for Reproductive Health, University of Edinburgh, EH16 4TJ, UK; Centre for Clinical Brain Sciences, Chancellor's Building, 49 Little France Crescent, University of Edinburgh, Edinburgh EH16 4SB, UK. Electronic address:

Preterm infants are at increased risk of alterations in brain structure and connectivity, and subsequent neurocognitive impairment. Breast milk may be more advantageous than formula feed for promoting brain development in infants born at term, but uncertainties remain about its effect on preterm brain development and the optimal nutritional regimen for preterm infants. We test the hypothesis that breast milk exposure is associated with improved markers of brain development and connectivity in preterm infants at term equivalent age. Read More

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http://dx.doi.org/10.1016/j.neuroimage.2018.09.045DOI Listing
January 2019
2 Reads

Structural and Functional Pulmonary Magnetic Resonance Imaging in Pediatrics-From the Neonate to the Young Adult.

Acad Radiol 2018 Sep 15. Epub 2018 Sep 15.

Center for Pulmonary Imaging Research, Division of Pulmonary Medicine and Department of Radiology, Cincinnati Children's Hospital Medical Center, 3333 Burnet Ave, Cincinnati, OH 45229; Departments of Radiology and Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH 45229. Electronic address:

The clinical imaging modalities available to investigate pediatric pulmonary conditions such as bronchopulmonary dysplasia, cystic fibrosis, and asthma are limited primarily to chest x-ray radiograph and computed tomography. As the challenges that historically limited the application of magnetic resonance imaging (MRI) to the lung have been overcome, its clinical potential has greatly expanded. In this review article, recent advances in pulmonary MRI including ultrashort echo time and hyperpolarized-gas MRI techniques are discussed with an emphasis on pediatric research and translational applications. Read More

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http://dx.doi.org/10.1016/j.acra.2018.08.006DOI Listing
September 2018
1 Read

Blast from the past: a novel complication of bronchopulmonary dysplasia.

BMJ Case Rep 2018 Jul 30;2018. Epub 2018 Jul 30.

Department of Pulmonology/Critical Care, Walter Reed National Military Medical Center, Bethesda, Maryland, USA.

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http://dx.doi.org/10.1136/bcr-2018-225005DOI Listing
July 2018
2 Reads

Urinary H-NMR Metabolomics in the First Week of Life Can Anticipate BPD Diagnosis.

Oxid Med Cell Longev 2018 28;2018:7620671. Epub 2018 Jun 28.

Department of Biomedical Sciences, University of Cagliari, Cagliari, Italy.

Despite the advancements in medical knowledge and technology, the etiopathogenesis of bronchopulmonary dysplasia (BPD) is not yet fully understood although oxidative stress seems to play a role, leading to a very demanding management of these patients by the neonatologist. In this context, metabolomics can be useful in understanding, diagnosing, and treating this illness since it is one of the newest omics science that analyzes the metabolome of an individual through the investigation of biological fluids such as urine and blood. In this study, 18 patients admitted to the Neonatal Intensive Care Unit of the Cagliari University Hospital were enrolled. Read More

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http://dx.doi.org/10.1155/2018/7620671DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6046120PMC
October 2018
1 Read

The cerebral hemodynamic response to phonetic changes of speech in preterm and term infants: The impact of postmenstrual age.

Neuroimage Clin 2018 15;19:599-606. Epub 2018 May 15.

Department of Pediatrics, Keio University School of Medicine, Shinjuku, Tokyo 160-8582, Japan.

Higher brain dysfunction, such as language delay, is a major concern among preterm infants. Cerebral substrates of cognitive development in preterm infants remain elusive, partly because of limited methods. The present study focuses on hemodynamic response patterns for brain function by using near-infrared spectroscopy. Read More

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http://dx.doi.org/10.1016/j.nicl.2018.05.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6029566PMC
January 2019
8 Reads

Oral indomethacin versus oral ibuprofen for treatment of patent ductus arteriosus: a randomised controlled study in very low-birthweight infants.

Paediatr Int Child Health 2018 08 18;38(3):187-192. Epub 2018 Jun 18.

a Division of Neonatology, Department of Pediatrics , Faculty of Medicine , Chiang Mai University , Chiang Mai , Thailand.

Background: In low- and middle-income countries (LMIC), haemodynamically significant patent ductus arteriosus (hsPDA) is treated with oral indomethacin (IDC) and ibuprofen (IB) instead of intravenous formulations. No significant differences in efficacy have been reported. However, previous studies had small numbers of VLBW infants (<1500 g). Read More

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http://dx.doi.org/10.1080/20469047.2018.1483566DOI Listing
August 2018
16 Reads

Neonatal Pulmonary Magnetic Resonance Imaging of Bronchopulmonary Dysplasia Predicts Short-Term Clinical Outcomes.

Am J Respir Crit Care Med 2018 Nov;198(10):1302-1311

1 Center for Pulmonary Imaging Research, Division of Pulmonary Medicine and Department of Radiology.

Rationale: Bronchopulmonary dysplasia (BPD) is a serious neonatal pulmonary condition associated with premature birth, but the underlying parenchymal disease and trajectory are poorly characterized. The current National Institute of Child Health and Human Development (NICHD)/NHLBI definition of BPD severity is based on degree of prematurity and extent of oxygen requirement. However, no clear link exists between initial diagnosis and clinical outcomes. Read More

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http://dx.doi.org/10.1164/rccm.201711-2287OCDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6290936PMC
November 2018
21 Reads

Hybrid surgery in treatment of pulmonary sequestration with abdominal aorta feeding vessel: a case report.

J Cardiothorac Surg 2018 May 18;13(1):44. Epub 2018 May 18.

Department of Thoracic surgery, West China Hospital, Sichuan University, Chengdu, 610000, China.

Background: Pulmonary sequestration is a rare congenital pulmonary dysplasia, which requires surgical resection (either via open thoracotomy or video-assisted thoracoscopic surgery [VATS] or via endoluminal occlusion of the abnormal feeding vessel).

Case Presentation: We described a 51-year-old female patient with a history of recurrent cough and repeated pneumonia. She was referred to our hospital for further work-up of pulmonary sequestration. Read More

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http://dx.doi.org/10.1186/s13019-018-0733-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5960101PMC
May 2018
2 Reads

Postnatal Microstructural Developmental Trajectory of Corpus Callosum Subregions and Relationship to Clinical Factors in Very Preterm Infants.

Sci Rep 2018 May 15;8(1):7550. Epub 2018 May 15.

Perinatal Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, United States of America.

Our objectives were to define the microstructural developmental trajectory of six corpus callosum subregions and identify perinatal clinical factors that influence early development of these subregions in very preterm infants. We performed a longitudinal cohort study of very preterm infants (32 weeks gestational age or younger) (N = 36) who underwent structural MRI and diffusion tensor imaging serially at four time points - before 32, 32, 38, and 52 weeks postmenstrual age. We divided the corpus callosum into six subregions, performed probabilistic tractography, and used linear mixed effects models to evaluate the influence of antecedent clinical factors on its microstructural growth trajectory. Read More

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http://dx.doi.org/10.1038/s41598-018-25245-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5954149PMC
May 2018
5 Reads
5.080 Impact Factor

He diffusion MRI in human lungs.

J Magn Reson 2018 Jul 26;292:90-98. Epub 2018 Apr 26.

ABQMR, Inc., 2301 Yale Blvd. SE, Suite C2, Albuquerque, NM 87106, USA; Department of Physics, Washington University, One Brookings Drive, CB 1105, St Louis, MO 63130, USA. Electronic address:

Hyperpolarized He gas allows the air spaces of the lungs to be imaged via MRI. Imaging of restricted diffusion is addressed here, which allows the microstructure of the lung to be characterized through the physical restrictions to gas diffusion presented by airway and alveolar walls in the lung. Measurements of the apparent diffusion coefficient (ADC) of He at time scales of milliseconds and seconds are compared; measurement of acinar airway sizes by determination of the microscopic anisotropy of diffusion is discussed. Read More

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http://dx.doi.org/10.1016/j.jmr.2018.04.007DOI Listing
July 2018
7 Reads

Permissive Hypercapnia Results in Decreased Functional Vessel Density in the Skin of Extremely Low Birth Weight Infants.

Front Pediatr 2018 13;6:52. Epub 2018 Mar 13.

Divsion of Neonatology, University Hospital of Leipzig, Leipzig, Germany.

Background: Ventilator-induced lung injury with subsequent bronchopulmonary dysplasia remains an important issue in the care of extremely low-birth-weight infants. Permissive hypercapnia has been proposed to reduce lung injury. Hypercapnia changes cerebral perfusion, but its influence on the peripheral microcirculation is unknown. Read More

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http://journal.frontiersin.org/article/10.3389/fped.2018.000
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http://dx.doi.org/10.3389/fped.2018.00052DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5890181PMC
March 2018
8 Reads

Successful Establishment of Primary Type II Alveolar Epithelium with 3D Organotypic Coculture.

Am J Respir Cell Mol Biol 2018 08;59(2):158-166

2 Program in Cancer Biology.

Alveolar type II (AT2) epithelial cells are uniquely specialized to produce surfactant in the lung and act as progenitor cells in the process of repair after lung injury. AT2 cell injury has been implicated in several lung diseases, including idiopathic pulmonary fibrosis and bronchopulmonary dysplasia. The inability to maintain primary AT2 cells in culture has been a significant barrier in the investigation of pulmonary biology. Read More

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http://dx.doi.org/10.1165/rcmb.2017-0442MADOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6096337PMC
August 2018
55 Reads

Diagnostic value of chest CT combined with x-ray for premature infants with bronchopulmonary dysplasia.

Medicine (Baltimore) 2018 Mar;97(9):e9723

Pediatric Center of the First People's Hospital of Jining City, Jining City, Shandong Province, China.

Bronchopulmonary dysplasia (BPD) is a common chronic lung disease in the newborns. Staging of BPD severity does not have a high predictive value for the outcomes. This study was aimed to assess the diagnostic value of chest computed tomography (CT) combined with x-ray for premature infants with BPD. Read More

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http://dx.doi.org/10.1097/MD.0000000000009723DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5851751PMC
March 2018
6 Reads

A Shared Pattern of β-Catenin Activation in Bronchopulmonary Dysplasia and Idiopathic Pulmonary Fibrosis.

Am J Pathol 2018 04 31;188(4):853-862. Epub 2018 Jan 31.

Mildred Stahlman Division of Neonatology, Department of Pediatrics, Vanderbilt University, Nashville, Tennessee.

Wnt/β-catenin signaling is necessary for normal lung development, and abnormal Wnt signaling contributes to the pathogenesis of both bronchopulmonary dysplasia (BPD) and idiopathic pulmonary fibrosis (IPF), fibrotic lung diseases that occur during infancy and aging, respectively. Using a library of human normal and diseased human lung samples, we identified a distinct signature of nuclear accumulation of β-catenin phosphorylated at tyrosine 489 and epithelial cell cytosolic localization of β-catenin phosphorylated at tyrosine 654 in early normal lung development and fibrotic lung diseases BPD and IPF. Furthermore, this signature was recapitulated in murine models of BPD and IPF. Read More

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http://dx.doi.org/10.1016/j.ajpath.2017.12.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5866104PMC
April 2018
13 Reads

Quantitative CT scans of lung parenchymal pathology in premature infants ages 0-6 years.

Pediatr Pulmonol 2018 Mar 21;53(3):316-323. Epub 2017 Dec 21.

Division of Pulmonary Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.

Background: Bronchopulmonary dysplasia (BPD) is a common, heterogeneous disease in premature infants. We hypothesized that quantitative CT techniques could assess lung parenchymal heterogeneity in BPD patients across a broad age range and demonstrate how pathologies change over time.

Methods: A cross-sectional, retrospective study of children age 0-6 years with non-contrast chest CT scans was conducted. Read More

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http://dx.doi.org/10.1002/ppul.23921DOI Listing
March 2018
6 Reads

Long-term pulmonary and cardiovascular morbidities of neonatal hyperoxia exposure in mice.

Int J Biochem Cell Biol 2018 01 7;94:119-124. Epub 2017 Dec 7.

Section of Neonatology, Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA. Electronic address:

Pulmonary hypertension (PH) frequently occurs in infants with bronchopulmonary dysplasia (BPD), causing increased mortality and right ventricular (RV) dysfunction that persists into adulthood. A first step in developing better therapeutic options is identifying and characterizing an appropriate animal model. Previously, we characterized the short-term morbidities of a model in which C57BL/6J wild-type (WT) mice were exposed to 70% O (hyperoxia) during the neonatal period. Read More

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http://dx.doi.org/10.1016/j.biocel.2017.12.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5745292PMC
January 2018
5 Reads

Successful Reversal of Furosemide-Induced Secondary Hyperparathyroidism With Cinacalcet.

Pediatrics 2017 Dec;140(6)

Sections of Nephrology, Bone and Mineral Disorder Clinic, and

Secondary hyperparathyroidism (SHPT) is a rare complication of furosemide therapy that can occur in patients treated with the loop diuretic for a long period of time. We report a 6-month-old 28-weeks premature infant treated chronically with furosemide for his bronchopulmonary dysplasia, who developed hypocalcemia and severe SHPT, adversely affecting his bones. Discontinuation of the loop diuretic and the addition of supplemental calcium and calcitriol only partially reversed the SHPT, bringing serum parathyroid hormone level down from 553 to 238 pg/mL. Read More

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http://dx.doi.org/10.1542/peds.2016-3789DOI Listing
December 2017
16 Reads

Pulmonary Artery Pressures in School-Age Children Born Prematurely.

J Pediatr 2017 12;191:42-49.e3

Division of Asthma, Allergy and Lung Biology, Medical Research Council Centre for Allergic Mechanisms in Asthma, King's College London, London, United Kingdom; NIHR Biomedical Research Centre at Guy's & St Thomas NHS Foundation Trust and King's College London, London, United Kingdom. Electronic address:

Objectives: To test the hypothesis that pulmonary artery pressures were higher in school aged children born extremely premature than those born at term. We also wanted to assess whether pulmonary artery pressures differed between children born prematurely with or without bronchopulmonary dysplasia (BPD) or between those randomized in the neonatal period to different ventilation modes.

Study Design: Transthoracic echocardiography was performed on 193 children born extremely premature (106 had BPD) and 110 children born at term when they were 11-14 years of age. Read More

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http://dx.doi.org/10.1016/j.jpeds.2017.08.034DOI Listing
December 2017
4 Reads

An Echocardiographic Screening Program Helps to Identify Pulmonary Hypertension in Extremely Low Birthweight Infants with and without Bronchopulmonary Dysplasia: A Single-Center Experience.

Neonatology 2018 8;113(1):81-88. Epub 2017 Nov 8.

Division of Neonatology, Children's Hospital, University of Cologne, Cologne, Germany.

Background: Pulmonary hypertension (PH) affects 1 in 6 infants with a birthweight <1,000 g (extremely low birthweight; ELBW) and is frequently associated with bronchopulmonary dysplasia (BPD). If untreated, the mortality rates of the disease are high.

Objectives: The aim of this study was to characterize risk factors for PH in ELBW infants and to describe the timing of onset of the disease by setting up a screening program. Read More

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http://dx.doi.org/10.1159/000480694DOI Listing
August 2018
2 Reads

Human amnion cells reverse acute and chronic pulmonary damage in experimental neonatal lung injury.

Stem Cell Res Ther 2017 Nov 10;8(1):257. Epub 2017 Nov 10.

The Ritchie Centre, Hudson Institute of Medical Research, Clayton, VIC, Australia.

Background: Despite advances in neonatal care, bronchopulmonary dysplasia (BPD) remains a significant contributor to infant mortality and morbidity. While human amnion epithelial cells (hAECs) have shown promise in small and large animal models of BPD, there is scarce information on long-term benefit and clinically relevant questions surrounding administration strategy remain unanswered. In assessing the therapeutic potential of hAECs, we investigated the impact of cell dosage, administration routes and timing of treatment in a pre-clinical model of BPD. Read More

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http://dx.doi.org/10.1186/s13287-017-0689-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5681809PMC
November 2017
20 Reads

Asymmetry of cerebral glucose metabolism in very low-birth-weight infants without structural abnormalities.

PLoS One 2017 2;12(11):e0186976. Epub 2017 Nov 2.

Department of Nuclear Medicine, Keimyung University Dongsan Medical Center, Daegu, Republic of Korea.

Methods: Thirty-six VLBW infants who underwent F-18 fluorodeoxyglucose (F-18 FDG) brain PET and MRI were prospectively enrolled, while infants with evidence of parenchymal brain injury on MRI were excluded. The regional glucose metabolic ratio and asymmetry index were calculated. The asymmetry index more than 10% (right > left asymmetry) or less than -10% (left > right asymmetry) were defined as abnormal. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0186976PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5667759PMC
December 2017
14 Reads

Progression of Right Ventricular Systolic Dysfunction Detected by Myocardial Deformation Imaging in Asymptomatic Preterm Children.

J Cardiovasc Ultrasound 2017 Sep 29;25(3):98-104. Epub 2017 Sep 29.

Department of Diagnostic Laboratory Medicine, CHA Bundang Medical Center, CHA University School of Medicine, Seongnam, Korea.

Background: To detect progression of right ventricular (RV) systolic dysfunction (RVSD) in asymptomatic preterm children from infancy to 24-month corrected age, using velocity vector imaging (VVI).

Methods: Retrospective study comparing sequential RV longitudinal peak systolic strain (LPSS) from 24 children born at < 33 weeks of gestational age and 10 term infants recruited as controls, obtained at a mean of 4-month (first exam) and 24-month corrected age (second exam).

Results: In 7/24 (29. Read More

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http://dx.doi.org/10.4250/jcu.2017.25.3.98DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5658295PMC
September 2017
6 Reads

[Readmission of children with bronchopulmonary dysplasia in the first 2 years of life: a clinical analysis of 121 cases].

Zhongguo Dang Dai Er Ke Za Zhi 2017 Oct;19(10):1056-1060

Department of Respiratory Diseases, Children's Hospital of Chongqing Medical University/Ministry of Education Key Laboratory of Child Development and Disorders/China International Science and Technology Cooperation Base of Child Development and Critical Disorders/Chongqing Engineering Research Center of Stem Cell Therapy, Chongqing 400014, China.

Objective: To investigate the clinical features of readmitted children with bronchopulmonary dysplasia (BPD) in the first 2 years of life.

Methods: A retrospective analysis was performed for the clinical data of 242 children with BPD who were readmitted due to recurrent lower respiratory tract infection (LRTI) in the first 2 years of life.

Results: Among all the 242 children with BPD, 115(47. Read More

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October 2017
15 Reads

Bronchopulmonary dysplasia-associated pulmonary hypertension: clues from placental pathology.

J Perinatol 2017 12 7;37(12):1310-1314. Epub 2017 Sep 7.

Monash Newborn, Monash University Neonatologist, Monash Children's Hospital, Melbourne, VIC, Australia.

Objectives: Bronchopulmonary dysplasia (BPD) and the associated complication of pulmonary hypertension (PH) leads to increased mortality and a longer length of stay among survivors. Placental histopathology may give early clues of subsequent events. The objective was to evaluate the relationship of maternal vascular underperfusion (MVU) changes on placental histopathology with subsequent development of BPD-associated PH in a cohort of extremely premature infants. Read More

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http://dx.doi.org/10.1038/jp.2017.130DOI Listing
December 2017
1 Read

Pessary or Progesterone to Prevent Preterm delivery in women with short cervical length: the Quadruple P randomised controlled trial.

BMC Pregnancy Childbirth 2017 Sep 4;17(1):284. Epub 2017 Sep 4.

Department of Obstetrics and Gynaecology, Academic Medical Center (AMC), Meibergdreef 9, 1105, AZ, Amsterdam, The Netherlands.

Background: Preterm birth is in quantity and in severity the most important topic in obstetric care in the developed world. Progestogens and cervical pessaries have been studied as potential preventive treatments with conflicting results. So far, no study has compared both treatments. Read More

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http://dx.doi.org/10.1186/s12884-017-1454-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5584011PMC
September 2017
35 Reads

Medical Progress Series: Bronchopulmonary Dysplasia at 50 Years-An Introduction.

Authors:
Steven H Abman

J Pediatr 2017 09;188:18-18.e1

Department of Pediatrics University of Colorado School of Medicine and Children's Hospital Colorado Aurora, Colorado. Electronic address:

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http://dx.doi.org/10.1016/j.jpeds.2017.07.004DOI Listing
September 2017
1 Read

Diagnostic Approach to Pulmonary Hypertension in Premature Neonates.

Children (Basel) 2017 Aug 24;4(9). Epub 2017 Aug 24.

Division of Neonatology, Department of Pediatrics, The Women & Children's Hospital of Buffalo, University at Buffalo, 219 Bryant Street, Buffalo, NY 14222-2006, USA.

Bronchopulmonary dysplasia (BPD) is a form of chronic lung disease in premature infants following respiratory distress at birth. With increasing survival of extremely low birth weight infants, alveolar simplification is the defining lung characteristic of infants with BPD, and along with pulmonary hypertension, increasingly contributes to both respiratory morbidity and mortality in these infants. Growth restricted infants, infants born to mothers with oligohydramnios or following prolonged preterm rupture of membranes are at particular risk for early onset pulmonary hypertension. Read More

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http://dx.doi.org/10.3390/children4090075DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5615265PMC
August 2017
9 Reads

Neurological consequences of systemic inflammation in the premature neonate.

Neural Regen Res 2017 Jun;12(6):890-896

OMNI Academic Service Line and Division of Neonatology, Department of Pediatrics, Kentucky Children's Hospital, College of Medicine, University of Kentucky, Lexington, KY, USA.

Despite substantial progress in neonatal care over the past two decades leading to improved survival of extremely premature infants, extreme prematurity continues to be associated with long term neurodevelopmental impairments. Cerebral white matter injury is the predominant form of insult in preterm brain leading to adverse neurological consequences. Such brain injury pattern and unfavorable neurologic sequelae is commonly encountered in premature infants exposed to systemic inflammatory states such as clinical or culture proven sepsis with or without evidence of meningitis, prolonged mechanical ventilation, bronchopulmonary dysplasia, necrotizing enterocolitis and chorioamnionitis. Read More

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http://dx.doi.org/10.4103/1673-5374.208547DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5514858PMC
June 2017
4 Reads

Fetal Doppler velocimetry and bronchopulmonary dysplasia risk among growth-restricted preterm infants: an observational study.

BMJ Open 2017 Jul 20;7(7):e015232. Epub 2017 Jul 20.

Division of Neonatology, Fondazione Policlinico Universitario A. Gemelli-Università Cattolica del Sacro Cuore, Rome, Italy.

Objective: To investigate whether fetal growth restriction (FGR) diagnosis, based on pathological prenatal fetal Doppler velocimetry, is associated with bronchopulmonary dysplasia (BPD) independently of being small for gestational age (SGA) per se at birth among very preterm infants.

Design: Prospective, observational study. FGR was defined as failing fetal growth in utero and fetal Doppler velocimetry abnormalities. Read More

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http://dx.doi.org/10.1136/bmjopen-2016-015232DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5541508PMC
July 2017
15 Reads

Imaging Bronchopulmonary Dysplasia-A Multimodality Update.

Front Med (Lausanne) 2017 29;4:88. Epub 2017 Jun 29.

Great Ormond Street Hospital, London, United Kingdom.

Bronchopulmonary dysplasia is the most common form of infantile chronic lung disease and results in significant health-care expenditure. The roles of chest radiography and computed tomography (CT) are well documented but numerous recent advances in imaging technology have paved the way for newer imaging techniques including structural pulmonary assessment lung magnetic resonance imaging (MRI), functional assessment ventilation, and perfusion MRI and quantitative imaging techniques using both CT and MRI. New applications for ultrasound have also been suggested. Read More

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http://dx.doi.org/10.3389/fmed.2017.00088DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5497953PMC
June 2017
6 Reads

Structural and functional ventilatory impairment in infants with severe bronchopulmonary dysplasia.

Pediatr Pulmonol 2017 08 3;52(8):1029-1037. Epub 2017 Jul 3.

Division of Pediatric Respiratory Medicine, Department of Pediatrics, Erasmus MC-Sophia, University Medical Center Rotterdam, Rotterdam, the Netherlands.

Background: Bronchopulmonary dysplasia (BPD) is the most frequent serious complication in preterm infants. We aimed to describe lung structure and ventilatory function of preterm infants with severe BPD and explored the association between early postnatal growth and these outcomes.

Methods: We included preterm infants born ≤32 weeks gestational age (GA) with severe BPD. Read More

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http://dx.doi.org/10.1002/ppul.23696DOI Listing
August 2017
10 Reads

Association between early echocardiography, therapy for patent ductus arteriosus, and outcomes in very low birth weight infants.

Cardiol Young 2017 Nov 19;27(9):1732-1739. Epub 2017 Jun 19.

3Department of Pediatrics,Duke University School of Medicine,Durham,North Carolina,United States of America.

Background: In very low birth weight infants, persistence of a patent ductus arteriosus results in morbidity and mortality. Therapies to close the ductus are effective, but clinical outcomes may depend on the accuracy of diagnosis and the timing of administration. The objective of the present study was to characterise the association between early echocardiography, therapy for patent ductus arteriosus, and outcomes in very low birth weight infants. Read More

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https://www.cambridge.org/core/product/identifier/S104795111
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http://dx.doi.org/10.1017/S1047951117001081DOI Listing
November 2017
26 Reads

Interstitial pneumonia pattern on day 7 chest radiograph predicts bronchopulmonary dysplasia in preterm infants.

BMC Pediatr 2017 05 15;17(1):125. Epub 2017 May 15.

Department of Pediatrics, Seoul National University College of Medicine, Seoul, Republic of Korea.

Background: Early identification of infants at higher risk of developing bronchopulmonary dysplasia (BPD) may enable a targeted approach to reduce BPD. We aimed to evaluate the hypothesis that the interstitial pneumonia pattern on the day 7 chest radiograph predicts BPD or death before 36 weeks postmenstrual age (PMA).

Methods: A retrospective cohort study was performed on 336 preterm infants (birth weight < 1500 g and gestational age < 32 postmenstrual weeks) who were admitted to a single tertiary academic center between January 2008 and December 2014. Read More

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http://dx.doi.org/10.1186/s12887-017-0881-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5433188PMC
May 2017
18 Reads

Maturational Patterns of Systolic Ventricular Deformation Mechanics by Two-Dimensional Speckle-Tracking Echocardiography in Preterm Infants over the First Year of Age.

J Am Soc Echocardiogr 2017 Jul 19;30(7):685-698.e1. Epub 2017 Apr 19.

Department of Pediatrics, Washington University School of Medicine, St. Louis, Missouri.

Background: The aim of this study was to determine the maturational changes in systolic ventricular strain mechanics by two-dimensional speckle-tracking echocardiography in extremely preterm neonates from birth to 1 year of age and discern the impact of common cardiopulmonary abnormalities on the deformation measures.

Methods: In a prospective multicenter study of 239 extremely preterm infants (<29 weeks gestation at birth), left ventricular (LV) global longitudinal strain (GLS) and global longitudinal systolic strain rate (GLSRs), interventricular septal wall (IVS) GLS and GLSRs, right ventricular (RV) free wall longitudinal strain and strain rate, and segmental longitudinal strain in the RV free wall, LV free wall, and IVS were serially measured on days 1, 2, and 5 to 7, at 32 and 36 weeks postmenstrual age, and at 1 year corrected age (CA). Premature infants who developed bronchopulmonary dysplasia or had echocardiographic findings of pulmonary hypertension were analyzed separately. Read More

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http://dx.doi.org/10.1016/j.echo.2017.03.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5495609PMC
July 2017
48 Reads

Reliability of Echocardiographic Indicators of Pulmonary Vascular Disease in Preterm Infants at Risk for Bronchopulmonary Dysplasia.

J Pediatr 2017 07 12;186:29-33. Epub 2017 Apr 12.

Section of Critical Care, Department of Pediatrics, University of Colorado School of Medicine, Aurora, CO; The Pediatric Heart-Lung Center, Department of Pediatrics, University of Colorado School of Medicine, Aurora, CO.

Objectives: To determine the assessment and inter-rater reliability of echocardiographic evaluations of pulmonary vascular disease (PVD) in preterm infants at risk for bronchopulmonary dysplasia.

Study Design: We prospectively studied echocardiograms from preterm infants (birthweights 500-1250 g) at 7 days of age and 36 weeks postmenstrual age (PMA). Echocardiograms were assessed by both a cardiologist on clinical service and a single research cardiologist. Read More

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http://dx.doi.org/10.1016/j.jpeds.2017.03.027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5493442PMC
July 2017
19 Reads

Velocity vector imaging shows normal cardiac systolic function in survivors of severe bronchopulmonary dysplasia at six to 16 years of age.

Acta Paediatr 2017 Jul 26;106(7):1136-1141. Epub 2017 Apr 26.

Department of Pediatrics, Tampere University Hospital, Tampere, Finland.

Aim: This study evaluated global myocardial function and associations between cardiac function and lung function in very low birth weight (VLBW) children, with and without severe radiographic bronchopulmonary dysplasia (BPD), at six to 14 years of age.

Methods: We studied 34 VLBW and 19 term-born controls, and the VLBW group was further divided into a BPD group with severe radiographic BPD and those without radiographic BPD in infancy. Detailed right and left ventricular myocardial functions were analysed by velocity vector imaging, and the left ventricular mass was calculated. Read More

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http://doi.wiley.com/10.1111/apa.13860
Publisher Site
http://dx.doi.org/10.1111/apa.13860DOI Listing
July 2017
17 Reads

Evaluation of left ventricular function in preterm infants with bronchopulmonary dysplasia using various echocardiographic techniques.

Echocardiography 2017 Apr 31;34(4):567-576. Epub 2017 Mar 31.

Perinatal Cardiology Unit, Medical University of Warsaw, Warsaw, Poland.

Aim: Echocardiographic evaluation of left ventricular function in preterm infants with and without bronchopulmonary dysplasia.

Methods: In 82 preterm infants (32 in no-bronchopulmonary-dysplasia group, 35 in mild-bronchopulmonary-dysplasia group, and 15 in severe-bronchopulmonary-dysplasia group), echocardiography was performed on the first day of life, at 28 days of life, and at 36 weeks postconceptional age.

Results: The mean E/A ratio at 36 PCA was 0. Read More

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http://dx.doi.org/10.1111/echo.13488DOI Listing
April 2017
2 Reads

Two-Year Follow-Up Outcomes of Premature Infants Enrolled in the Phase I Trial of Mesenchymal Stem Cells Transplantation for Bronchopulmonary Dysplasia.

J Pediatr 2017 06 21;185:49-54.e2. Epub 2017 Mar 21.

Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea; Department of Health Sciences and Technology, Samsung Advanced Institute for Health Sciences & Technology, Sungkyunkwan University, Seoul, Republic of Korea; Stem Cell and Regenerative Medicine Institute, Samsung Medical Center, Seoul, Republic of Korea. Electronic address:

Objective: To determine the long-term safety and outcomes of mesenchymal stem cells (MSCs) for bronchopulmonary dysplasia in premature infants enrolled in a previous phase I clinical trial up to 2 years of corrected age (CA).

Study Design: We assessed serious adverse events, somatic growth, and respiratory and neurodevelopmental outcomes at visit 1 (4-6 months of CA), visit 2 (8-12 months of CA), and visit 3 (18-24 months of CA) in a prospective longitudinal follow-up study up to 2 years' CA of infants who received MSCs (MSC group). We compared these data with those from a historical case-matched comparison group. Read More

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http://dx.doi.org/10.1016/j.jpeds.2017.02.061DOI Listing
June 2017
19 Reads

Echocardiographic evaluation of right ventricular function in preterm infants with bronchopulmonary dysplasia.

Echocardiography 2017 Apr 23;34(4):577-586. Epub 2017 Feb 23.

Perinatal Cardiology Unit, Medical University of Warsaw, Warsaw, Poland.

Aim: To evaluate right ventricular function in preterm infants with and without bronchopulmonary dysplasia.

Methods: Eighty-nine preterm infants (<32 weeks) were divided into three groups: (1) no-bronchopulmonary dysplasia (n=32); (2) mild-bronchopulmonary dysplasia (n=35); (3) severe-bronchopulmonary dysplasia (n=15). Right ventricular echocardiographic parameters included the following: (1) pulsed-wave Doppler through the tricuspid valve (E/A ratio), pulmonary artery acceleration time, right ventricular ejection time, right ventricular velocity-time integral; (2) tissue Doppler measurements of myocardial velocities and atrioventricular conduction times; (3) pulsed-wave Doppler and tissue Doppler evaluation of myocardial performance index and E/E' ratio; and (4) M-mode detection of right ventricular end-diastolic wall diameter. Read More

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http://dx.doi.org/10.1111/echo.13489DOI Listing
April 2017
2 Reads

Hyperpolarized Helium-3 Diffusion-weighted Magnetic Resonance Imaging Detects Abnormalities of Lung Structure in Children With Bronchopulmonary Dysplasia.

J Thorac Imaging 2017 Sep;32(5):323-332

*Department of Radiology, University of Virginia School of Medicine ‡Department of Pediatrics, University of Virginia Health System §Public Health Science, School of Medicine, University of Virginia, Charlottesville, VA †Department of Radiology, University of Missouri School of Medicine, Columbia, MO.

Purpose: The aim of the study was to determine whether hyperpolarized He diffusion-weighted magnetic resonance imaging detects abnormalities in the lungs in children with bronchopulmonary dysplasia (BPD) as compared with age-matched normal children.

Materials And Methods: All experiments were compliant with Health Insurance Portability and Accountability Act (HIPAA) and performed with Food and Drug Administration approval under an IND application. The protocol was approved by our Institutional Review Board, and written informed consent was obtained. Read More

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http://dx.doi.org/10.1097/RTI.0000000000000244DOI Listing
September 2017
2 Reads

Pulmonary hypertension in preterm infants: results of a prospective screening program.

J Perinatol 2017 05 16;37(5):572-577. Epub 2017 Feb 16.

Department of Pediatrics, Section of Neonatal-Perinatal Medicine, Yale University School of Medicine, New Haven, CT, USA.

Objective: Determine prevalence and associations with pulmonary hypertension (PH) in preterm infants.

Study Design: Prospective institutional echocardiographic PH screening at 36 to 38 weeks' corrected gestational age (GA) for infants born <32 weeks' GA who had bronchopulmonary dysplasia (BPD; group BPD), and infants without BPD who had a birth weight (BW) <750 g, or clinical suspicion for PH (group NoBPD).

Results: Two hundred and four infants were screened (GA 25. Read More

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http://dx.doi.org/10.1038/jp.2016.255DOI Listing
May 2017
11 Reads

Fetal and neonatal outcomes of preterm infants born before 32 weeks of gestation according to antenatal vs postnatal assessments of restricted growth.

Am J Obstet Gynecol 2017 05 8;216(5):516.e1-516.e10. Epub 2017 Feb 8.

Inserm UMR 1153, Obstetrical, Perinatal and Pediatric Epidemiology Research Team (Epopé), Center for Epidemiology and Statistics Sorbonne Paris Cité, DHU Risks in Pregnancy, Paris Descartes University, Paris, France.

Background: Fetal growth restriction is defined using ultrasound parameters during pregnancy or as a low birthweight for gestational age after birth, but these definitions are not always concordant.

Objective: The purpose of this study was to investigate fetal and neonatal outcomes based on antenatal vs postnatal assessments of growth restriction.

Study Design: From the EPIPAGE 2 population-based prospective study of very preterm births in France in 2011, we included 2919 singleton nonanomalous infants 24-31 weeks gestational age. Read More

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http://dx.doi.org/10.1016/j.ajog.2017.02.001DOI Listing
May 2017
22 Reads