658 results match your criteria Imaging in Bronchiolitis Obliterans Organizing Pneumonia


Organizing Pneumonia: A Clinical Challenge in a Child With Previous Rhabdomyosarcoma.

J Investig Med High Impact Case Rep 2022 Jan-Dec;10:23247096221084840

Centro Hospitalar Universitário de São João, Porto, Portugal.

Organizing pneumonia is a pulmonary disease of undefined etiology, with few reported cases in children. It may be secondary to chemotherapy, radiation therapy, infectious agents, or hematopoietic cell transplantation. We present a case of an 18-year-old boy who presented to a follow-up consult with respiratory symptoms at the age of 11 years, 8 years after finishing treatment for a prostatic relapse of a pelvic rhabdomyosarcoma. Read More

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Cryptogenic Organizing Pneumonia.

N Engl J Med 2022 Mar;386(11):1058-1069

From the University of California, San Francisco (T.E.K.); and the University of Colorado Anschutz Medical Campus, Aurora (J.S.L.).

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Delayed-onset Organizing Pneumonia Emerging after Recovery from Coronavirus Disease 2019: A Report of Three Cases Diagnosed Using Transbronchial Cryobiopsy and a Review of the Literature.

Intern Med 2022 May 5;61(9):1403-1410. Epub 2022 Mar 5.

Department of Respiratory Medicine, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Japan.

We present three cases with an atypical clinical course of organizing pneumonia (OP) secondary to coronavirus disease 2019 (COVID-19). Three patients were discharged with satisfactory improvement after standard steroid therapy for COVID-19. Shortly after the completion of treatment, the patients experienced a flare-up of symptoms. Read More

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Organizing Pneumonia Secondary to Pulmonary Actinomycosis: A Case Report and Literature Review.

Cureus 2022 Jan 11;14(1):e21133. Epub 2022 Jan 11.

Pulmonary and Critical Care Medicine, University of Missouri Kansas City School of Medicine, Kansas City, USA.

Pulmonary actinomycosis is a common clinical infection caused by species. Although its treatment is very effective with Intravenous (IV) antibiotics, its diagnosis is challenging and easily missed. Organizing Pneumonia (OP) can be cryptogenic or secondary to different clinical diseases. Read More

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January 2022

Algorithmic Approach to the Diagnosis of Organizing Pneumonia: A Correlation of Clinical, Radiologic, and Pathologic Features.

Chest 2022 Jan 14. Epub 2022 Jan 14.

Northwell Health Lung Institute, and Zucker School of Medicine at Hofstra/Northwell, Hempstead, NY. Electronic address:

Organizing pneumonia (OP), characterized histopathologically by patchy filling of alveoli and bronchioles by loose plugs of connective tissue, may be seen in a variety of conditions. These include but are not limited to after an infection, drug reactions, radiation therapy, and collagen vascular diseases. When a specific cause is responsible for this entity, it is referred to as "secondary OP. Read More

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January 2022

Two cases of cryptogenic organizing pneumonia masquerading as tuberculosis (TB) in a TB endemic area.

Respirol Case Rep 2022 Jan 29;10(1):e0883. Epub 2021 Nov 29.

Respiratory Unit University Kebangsaan Malaysia Medical Centre Kuala Lumpur Malaysia.

Before the era of COVID-19 pandemic, organizing pneumonia (OP) is often underdiagnosed while tuberculosis (TB) is overdiagnosed especially in an endemic area. We report two patients with cryptogenic OP mimicking TB. First, a 56-year-old lady with right upper lobe air space opacity and, second, a 37-year-old lady with left upper lobe cavitary lesion. Read More

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January 2022

Organising pneumonia manifesting as a late-phase complication of COVID-19.

BMJ Case Rep 2021 Oct 29;14(10). Epub 2021 Oct 29.

Respiratory Unit, Department of Medicine, Pusat Perubatan Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia.

Acute COVID-19 usually lasts 4 weeks from the onset of symptoms. We report two cases of COVID-19-associated organising pneumonia (OP) occurring beyond 4 weeks from the acute onset of symptoms. Both tested positive for SARS reverse transcription-PCR 2 months before presentation with a resolution of respiratory symptoms. Read More

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October 2021

Content-based Image Retrieval by Using Deep Learning for Interstitial Lung Disease Diagnosis with Chest CT.

Radiology 2022 01 12;302(1):187-197. Epub 2021 Oct 12.

From the Department of Radiology and Research Institute of Radiology (J.C., H.J.H., J.B.S., S.M.L., K.J., R.P., J.K., N.K.), Department of Convergence Medicine, Biomedical Engineering Research Center (J. Yun), and Department of Clinical Epidemiology and Biostatistics (M.J.K.), University of Ulsan College of Medicine, Asan Medical Center, 86 Asanbyeongwon-Gil, Songpa-Gu, Seoul 138-735, Korea; Department of Radiology, Soonchunhyang University Seoul Hospital, Soonchunhyang University College of Medicine, Seoul, Korea (J.J.); Department of Internal Medicine, Ajou University School of Medicine, Suwon, Korea (Y.L.); Department of Internal Medicine, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea (H.J.); and Coreline Soft, Seoul, Korea (J. Yi, D.Y., B.K.).

Background Evaluation of interstitial lung disease (ILD) at CT is a challenging task that requires experience and is subject to substantial interreader variability. Purpose To investigate whether a proposed content-based image retrieval (CBIR) of similar chest CT images by using deep learning can aid in the diagnosis of ILD by readers with different levels of experience. Materials and Methods This retrospective study included patients with confirmed ILD after multidisciplinary discussion and available CT images identified between January 2000 and December 2015. Read More

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January 2022

Acute fibrinous and organizing pfneumonia: two case reports and literature review.

Diagn Pathol 2021 Oct 10;16(1):90. Epub 2021 Oct 10.

Division of Pulmonary and Critical Care Medicine, the First Affiliated Hospital of Sun Yat-sen University, Institute of Pulmonary Diseases, Sun Yat-sen University, Province Guangdong, 510080, Guangzhou, People's Republic of China.

Background: Acute fibrinous and organizing pneumonia (AFOP) is a rare histologic interstitial pneumonia pattern characterized by the intra-alveolar fibrin deposition and organizing pneumonia. Its clinical characteristics are still not well known and there is no consensus on treatment yet.

Case Presentation: We report two female cases in their fifties diagnosed with AFOP confirmed by a second lung biopsy. Read More

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October 2021

Cryptogenic organising pneumonia: current understanding of an enigmatic lung disease.

Eur Respir Rev 2021 Sep 17;30(161). Epub 2021 Aug 17.

Dept of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.

Organising pneumonia (OP) is currently recognised as a nonspecific lung injury response that is associated with a variety of imaging patterns obtained with high-resolution computed tomography (HRCT) of the chest and is characterised histopathologically by the presence of inflammatory cells and a connective tissue matrix within distal airspaces of the lungs. OP is associated with many conditions that include connective tissue disorders, various infections, drug reactions, hypersensitivity pneumonitis and aspiration. When OP cannot be linked to an associated condition and appears to be idiopathic, it is termed cryptogenic organising pneumonia. Read More

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September 2021

[Update 2021: Pulmonary Sequelae of COVID-19 Pneumonia].

Dtsch Med Wochenschr 2021 Jul 13;146(13-14):927-932. Epub 2021 Jul 13.

Acute COVID-19 pneumonia may result in persistent changes with various imaging and histopathological patterns, including organizing pneumonia and pulmonary fibrosis. In addition, SARS-CoV-2 infection is associated with increased risk of pulmonary vascular endothelialitis and thrombosis. Herein, current findings on pulmonary consequences of COVID-19 with implications for clinical management are summarized based on a selective literature review. Read More

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Dyspnea in a 57-Year-Old Man With Recent Viral Illness.

Chest 2021 07;160(1):e19-e24

Department of Pulmonary and Critical Care, Albany Medical Center, Albany, NY.

Case Presentation: A 57-year-old man presented to the ED with a 1-month history of nonproductive cough and shortness of breath. The patient had been in his usual state of health until 2 months before presentation, when he experienced an episode of nonproductive cough and shortness of breath. He was diagnosed clinically with an upper respiratory tract infection; the symptoms resolved after 7 days with conservative therapy alone. Read More

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Organizing pneumonia in ALK+ lung adenocarcinoma treated with ceritinib: A case report and literature review.

Medicine (Baltimore) 2021 Jul;100(26):e26449

Department of Cardiothoracic Surgery.

Rationale: Anaplastic lymphoma kinase (ALK) inhibitors have been approved for patients with ALK-rearrangement lung cancer. The effect is superior to the standard first-line therapy of pemetrexed plus platinum-based chemotherapy. However, ALK inhibitors are associated with rare and sometimes fatal adverse events. Read More

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Integrated approach to bronchoalveolar lavage cytology to distinguish interstitial lung diseases.

Eur J Intern Med 2021 07 28;89:76-80. Epub 2021 Apr 28.

Department of Medical Sciences, Surgery and Neurosciences, Respiratory Disease and Lung Transplant Unit, Siena University, Siena, Italy.

Background: Broncho-alveolar lavage (BAL) is a safe diagnostic procedure, useful for differentiating fibrotic lung disorders and for excluding malignancy and infection. A recent multicenter study demonstrated a new, relatively sensitive, and specific index called Bronchoalveolar Cytology Threshold (BCT), useful for distinguishing healthy individuals from patients with lung diseases.

Objectives: In our study, BCT was applied for the first time to the analysis of interstitial lung diseases (ILDs), investigating its potential for differential diagnosis. Read More

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Epirubicin and Cyclophosphamide-induced Acute Fibrinous and Organizing Pneumonia.

Am J Respir Crit Care Med 2021 10;204(8):e92-e93

Department of Respiratory Medicine and Allergology, Sapporo Medical University School of Medicine, Sapporo, Japan.

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October 2021

The clinicopathological analysis of organising pneumonia in myelodysplastic syndrome: high frequency in der(1;7)(q10; p10).

Br J Haematol 2021 07 14;194(1):214-217. Epub 2021 Apr 14.

Division of Hematology and Oncology, Department of Internal Medicine, St. Marianna University School of Medicine, Kawasaki, Japan.

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Reversed halo sign in radiation induced organizing pneumonia: natural course of the underlying pathophysiology.

Pulmonology 2021 Sep-Oct;27(5):460-464. Epub 2021 Apr 11.

Interstital Lung Disease Unit, Athens Medical Center, Athens, Greece; First Academic Department of Pneumonology, Hospital for Diseases of the Chest, "Sotiria", Medical School, National and Kapodistrian University of Athens, Greece. Electronic address:

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Comparison of Chest CT Findings of COVID-19, Influenza, and Organizing Pneumonia: A Multireader Study.

AJR Am J Roentgenol 2021 Nov 14;217(5):1093-1102. Epub 2021 Apr 14.

Department of Radiology, Division of Thoracic Imaging and Intervention, Massachusetts General Hospital, Boston, MA.

Previous studies compared CT findings of COVID-19 pneumonia with those of other infections; however, to our knowledge, no studies to date have included noninfectious organizing pneumonia (OP) for comparison. The objectives of this study were to compare chest CT features of COVID-19, influenza, and OP using a multireader design and to assess the performance of radiologists in distinguishing between these conditions. This retrospective study included 150 chest CT examinations in 150 patients (mean [± SD] age, 58 ± 16 years) with a diagnosis of COVID-19, influenza, or non-infectious OP (50 randomly selected abnormal CT examinations per diagnosis). Read More

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November 2021

Interstitial lung abnormality (ILA) and nonspecific interstitial pneumonia (NSIP).

Eur J Radiol Open 2021 16;8:100336. Epub 2021 Mar 16.

Center for Pulmonary Functional Imaging, Department of Radiology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.

This review article aims to address mysteries existing between Interstitial Lung Abnormality (ILA) and Nonspecific Interstitial Pneumonia (NSIP). The concept and definition of ILA are based upon CT scans from multiple large-scale cohort studies, whereas the concept and definition of NSIP originally derived from pathology with evolution to multi-disciplinary diagnosis. NSIP is the diagnosis as Interstitial Lung Disease (ILD) with clinical significance, whereas only a part of subjects with ILA have clinically significant ILD. Read More

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Diagnostic procedures and clinico-radiological findings of acute fibrinous and organizing pneumonia: a systematic review and pooled analysis.

Eur Radiol 2021 Oct 31;31(10):7283-7294. Epub 2021 Mar 31.

Department of Radiology, Seoul National University Hospital, Seoul National College of Medicine, Seoul, South Korea.

Objectives: To evaluate the clinico-radiological findings of acute fibrinous and organizing pneumonia (AFOP) in the literature according to whether a surgical or non-surgical biopsy was performed, as well as to identify prognostic predictors.

Methods: We searched the Embase and OVID-MEDLINE databases to identify studies that presented CT findings of AFOP and had extractable individual patient data. We compared the clinical and CT findings of the patients depending on whether a surgical or non-surgical biopsy was performed and identified survival predictors using a multivariate logistic regression analysis. Read More

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October 2021

Interstitial Lung Disease in Common Variable Immunodeficiency.

Front Immunol 2021 11;12:605945. Epub 2021 Mar 11.

Division of Clinical Immunology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, United States.

Interstitial lung disease (ILD) is a common complication in patients with common variable immunodeficiency (CVID) and often associated with other features, such as bronchiectasis and autoimmunity. As the ILD term encompasses different acute and chronic pulmonary conditions, the diagnosis is commonly made based on imaging features; histopathology is less frequently available. From a cohort of 637 patients with CVID followed at our center over 4 decades, we reviewed the data for 46 subjects (30 females, 16 males) who had lung biopsies with proven ILD. Read More

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A 69-Year-Old Woman With Ulcerative Colitis and Pulmonary Nodules.

Chest 2021 03;159(3):e147-e150

Department of Pulmonary and Critical Care, Ozarks Medical Center, West Plains, MO.

Case Presentation: A 69-year-old woman with a medical history significant for COPD, ulcerative colitis (UC), and tobacco dependence was referred to a pulmonologist for lung nodules found on routine annual low-dose CT scan for lung cancer screening. Her review of systems was negative for dyspnea, angina, hemoptysis, fever, night sweats, anorexia, and weight loss. She had a successful total proctocolectomy with ileal pouch-anal anastomosis performed 5 years ago because of acute fulminant UC refractory to corticosteroids and biologic agents. Read More

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A rare cause of secondary organising pneumonia.

BMJ Case Rep 2021 Mar 5;14(3). Epub 2021 Mar 5.

Pulmonology Department, Hospital Pedro Hispano, Matosinhos, Portugal.

Non-tuberculous mycobacterial pulmonary disease may have different clinical manifestations. We report a case of a 64-year-old woman presenting with persistent respiratory complaints, fever and radiological findings. Initially, she was diagnosed with community-acquired pneumonia, but after being submitted to an extensive investigation, including CT-guided transthoracic lung biopsy, a diagnosis of organising pneumonia (OP) was established. Read More

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Organizing pneumonia and COVID-19: A report of two cases.

Respir Med Case Rep 2021 31;32:101359. Epub 2021 Jan 31.

Department of Internal Medicine II at Santa Maria Hospital, Centro Hospitalar Universitário Lisboa Norte, EPE, Portugal.

Organizing pneumonia (OP) is a sub-acute process of pulmonary tissue repair secondary to lung injury, defined histopathologically by intra-alveolar buds of granulation tissue within the lumen of distal pulmonary airspaces. It can be either cryptogenic or secondary (SOP) to different clinical conditions, namely infections. Despite being nonspecific, its diagnosis can be made by the association of clinical and imaging criteria. Read More

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January 2021

Organizing pneumonia as a manifestation of coronavirus disease 2019.

Pathol Int 2021 03 27;71(3):210-212. Epub 2021 Jan 27.

Department of Pathology, University of Michigan, Ann Arbor, MI, USA.

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Disease-modifying antirheumatic drugs and organising pneumonia.

BMJ Case Rep 2021 Jan 6;14(1). Epub 2021 Jan 6.

Respiratory Unit, Department of Medicine, Faculty of Medicine, Universiti Kebangsaan Malaysia Medical Centre, Cheras, Kuala Lumpur, Malaysia

Organising pneumonia (OP) in rheumatoid arthritis (RA) may be part of pulmonary manifestation (disease related) or disease-modifying antirheumatic drugs (DMARDs) related. We report a case series of RA patients with DMARDs related OP. A 65-year-old woman developed OP 3 weeks after initiation of methotrexate (MTX). Read More

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January 2021

A 65-year-old Woman With Persistent Dyspnea, Arthritis, and Raynaud's Phenomenon.

Am J Med Sci 2021 04 22;361(4):526-533. Epub 2020 Nov 22.

Department of Pulmonary and Critical Care Medicine, Albany Medical Center, New York.

Antisynthetase syndrome (AS) is a rare disease that affects patients with inflammatory myopathies such as polymyositis (PM) and dermatomyositis (DM). In patients with AS, up to 95% of patients develop antisynthetase syndrome-associated interstitial lung disease (AS-ILD). Although AS-ILD commonly occurs in patients with a well-established diagnosis of AS, it can be the first or only manifestation of an occult AS. Read More

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COVID-19 mimics on chest CT: a pictorial review and radiologic guide.

Br J Radiol 2021 Feb 9;94(1118):20200703. Epub 2020 Dec 9.

Department of Radiology, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.

Chest imaging is often used as a complementary tool in the evaluation of coronavirus disease 2019 (COVID-19) patients, helping physicians to augment their clinical suspicion. Despite not being diagnostic for COVID-19, chest CT may help clinicians to isolate high suspicion patients with suggestive imaging findings. However, COVID-19 findings on CT are also common to other pulmonary infections and non-infectious diseases, and radiologists and point-of-care physicians should be aware of possible mimickers. Read More

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February 2021

A Duck after Treatment for Extensive Organizing Pneumonia.

Intern Med 2021 May 7;60(9):1477-1478. Epub 2020 Dec 7.

Respiratory Medicine and Infectious Diseases, Oita University Faculty of Medicine, Japan.

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Content-Based Image Retrieval of Chest CT with Convolutional Neural Network for Diffuse Interstitial Lung Disease: Performance Assessment in Three Major Idiopathic Interstitial Pneumonias.

Korean J Radiol 2021 02 21;22(2):281-290. Epub 2020 Oct 21.

Department of Radiology and Research Institute of Radiology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.

Objective: To assess the performance of content-based image retrieval (CBIR) of chest CT for diffuse interstitial lung disease (DILD).

Materials And Methods: The database was comprised by 246 pairs of chest CTs (initial and follow-up CTs within two years) from 246 patients with usual interstitial pneumonia (UIP, n = 100), nonspecific interstitial pneumonia (NSIP, n = 101), and cryptogenic organic pneumonia (COP, n = 45). Sixty cases (30-UIP, 20-NSIP, and 10-COP) were selected as the queries. Read More

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February 2021