571 results match your criteria Imaging in Bronchiolitis Obliterans Organizing Pneumonia


Cryptogenic Organizing Pneumonia Presenting as a Solitary Mass: Clinical, Imaging, and Pathologic Features.

Med Sci Monit 2019 Jan 16;25:466-474. Epub 2019 Jan 16.

Department of Radiology, Shanghai Dongfang Hospital, School of Medicine, Tongji University, Shanghai, China (mainland).

BACKGROUND Cryptogenic organizing pneumonia (COP), with a variety of radiologic findings, is a clinical pathological entity characterized by the presence of granulation tissue composed of fibroblasts/myofibroblasts and loose connective tissue in the alveoli and/or the distal bronchioles. Nevertheless, the presence of a solitary mass in COP is relatively rare. This study investigated the clinical, imaging, and pathologic features of COP with solitary mass form. Read More

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https://www.medscimonit.com/abstract/index/idArt/911655
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http://dx.doi.org/10.12659/MSM.911655DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6343522PMC
January 2019
7 Reads

Atoll sign: High resolution CT.

J Med Imaging Radiat Oncol 2018 Oct;62 Suppl 1:17

Department of Radiology, Concord Repatriation General Hospital, Concord, New South Wales, Australia.

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http://dx.doi.org/10.1111/1754-9485.05_12785DOI Listing
October 2018

Fatale immunmediierte organisierende Pneumonie unter Pembrolizumab – Therapie eines pulmonalen Adenokarzinoms.

Rofo 2018 Dec 4;190(12):1161-1163. Epub 2018 Sep 4.

Department of Respiratory and Critical Care Medicine and Ludwig-Boltzmann-Institute of COPD and Respiratory Epidemiology, Otto-Wagner-Spital, Vienna, Austria.

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http://dx.doi.org/10.1055/a-0640-3290DOI Listing
December 2018

Breast cancer and organising pneumonia: the importance of correlating the pathological findings with the clinical and radiological picture.

BMJ Case Rep 2018 Aug 29;2018. Epub 2018 Aug 29.

Department of Respiratory Medicine, Mid Cheshire Hospitals NHS Foundation Trust, Crewe, UK.

This case describes a female patient with a history of breast cancer who presented with a persistent cough and weight loss after a 17-year disease-free period. Radiologically there were new bilateral intrapulmonary nodules and areas of consolidation with a broad differential diagnosis. Brushings gained via bronchoscopy were suggestive of malignancy, but subsequent video-assisted thoracoscopic surgery wedge resection demonstrated organising pneumonia (OP) with no evidence of malignancy. Read More

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http://casereports.bmj.com/lookup/doi/10.1136/bcr-2018-22577
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http://dx.doi.org/10.1136/bcr-2018-225771DOI Listing
August 2018
10 Reads

Radiological findings of complications after lung transplantation.

Insights Imaging 2018 Oct 15;9(5):709-719. Epub 2018 Aug 15.

Division of Radiology, University Hospitals of Geneva, Rue Gabrielle-Perret-Gentil 4, Geneva, Switzerland.

Complications following lung transplantation may impede allograft function and threaten patient survival. The five main complications after lung transplantation are primary graft dysfunction, post-surgical complications, alloimmune responses, infections, and malignancy. Primary graft dysfunction, a transient ischemic/reperfusion injury, appears as a pulmonary edema in almost every patient during the first three days post-surgery. Read More

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http://dx.doi.org/10.1007/s13244-018-0647-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6206387PMC
October 2018
8 Reads

Bronchiolitis obliterans organising pneumonia as an initial manifestation in a patient with systemic lupus erythematosus: a rare presentation.

BMJ Case Rep 2018 May 26;2018. Epub 2018 May 26.

Wayne State University, Detroit, Michigan, USA.

Bronchiolitis obliterans organising pneumonia as an initial manifestation of systemic lupus erythematosus (SLE) is a rare and uncommon presentation. We describe a case of SLE presenting with shortness of breath, found to have pneumothorax, bilateral nodular infiltrates along with pleural effusions and pericardial effusion. Work-up suggested a diagnosis of active SLE with anaemia, thrombocytopenia, positive antinuclear antibodies (ANAs) and positive anti-double-stranded DNA. Read More

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http://dx.doi.org/10.1136/bcr-2017-224094DOI Listing
May 2018
3 Reads

Transient Asymptomatic Pulmonary Opacities During Osimertinib Treatment and its Clinical Implication.

J Thorac Oncol 2018 Aug;13(8):1106-1112

Division of Hematology-Oncology, Departments of Internal Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea. Electronic address:

Introduction: Osimertinib is an oral, potent, irreversible third-generation EGFR tyrosine kinase inhibitor approved for the treatment of T790M-positive NSCLC patients who failed first- or second-generation EGFR tyrosine kinase inhibitors. Interstitial lung disease (ILD) is a rare complication with osimertinib, occurring in 1% to 3% of patients. Recently, a relatively high incidence of transient asymptomatic pulmonary opacities (TAPOs), which are different from ILD, has been described. Read More

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http://dx.doi.org/10.1016/j.jtho.2018.04.038DOI Listing
August 2018
7 Reads

Rituximab in the Treatment of Interstitial Lung Disease Associated with Antisynthetase Syndrome: A Multicenter Retrospective Case Review.

J Rheumatol 2018 Jun 1;45(6):841-850. Epub 2018 Apr 1.

From the Departments of Medicine and Radiology, Brigham and Women's Hospital, Boston, Massachusetts; Departments of Medicine and Radiology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.

Objective: To assess clinical outcomes including imaging findings on computed tomography (CT), pulmonary function testing (PFT), and glucocorticoid (GC) use in patients with the antisynthetase syndrome (AS) and interstitial lung disease (ILD) treated with rituximab (RTX).

Methods: We retrospectively identified all patients at 2 institutions with AS-ILD who were treated with RTX. Baseline demographics, PFT, and chest CT were assessed before and after RTX. Read More

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http://dx.doi.org/10.3899/jrheum.170541DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5984657PMC
June 2018
21 Reads

Koinzidenz der kryptogen-organisierten Pneumonie und der perihepatischen Splenose – eine benigne Differenzialdiagnose zum metastasierten lepidischen Bronchialkarzinom.

Rofo 2018 07 7;190(7):640-642. Epub 2018 Mar 7.

Klinik und Poliklinik für Radiologie, Klinikum der Universität München, LMU München, Germany.

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http://dx.doi.org/10.1055/a-0576-1456DOI Listing
July 2018
9 Reads

Cryptogenic organizing pneumonia masquerading as lung carcinoma: A case report and review of the literature.

Exp Ther Med 2018 Jan 30;15(1):39-46. Epub 2017 Oct 30.

Department of Pharmacy, Beijing Tiantan Hospital Affiliated to Capital Medical University, Beijing 100050, P.R. China.

Cryptogenic organizing pneumonia (COP) is a rare pulmonary disorder of unknown etiology. COP with hemoptysis as the primary presenting symptom has rarely been reported. The present study reported a case of COP that resembled lung carcinoma with hemoptysis as the only clinical symptom. Read More

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http://www.spandidos-publications.com/10.3892/etm.2017.5393
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http://dx.doi.org/10.3892/etm.2017.5393DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5769272PMC
January 2018
4 Reads

[Clinical features of acute diffuse pulmonary exudative disorders].

Zhonghua Yi Xue Za Zhi 2017 Nov;97(44):3445-3449

Department of Respiratory and Critical Care Medicine, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020, China.

To analyze the clinical features of acute diffuse pulmonary exudative disorders. The data were collected from patients who were hospitalized in respiratory intensive care unit (RICU) of Beijing Chaoyang Hospital affiliated to the Capital Medical University during January 2009 to December 2011, and had acute clinical course with imaging findings of diffuse pulmonary infiltrated shadows (similar to acute respiratory distress syndrome (ARDS)). The causes of disease and clinical features were analyzed. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0376-2491.2017.44.002DOI Listing
November 2017
13 Reads

Cicatricial organising pneumonia mimicking a fibrosing interstitial pneumonia.

Histopathology 2018 Apr 29;72(5):846-854. Epub 2018 Jan 29.

Department of Radiology, Vancouver General Hospital and University of British Columbia, Vancouver, BC, Canada.

Aims: Organising pneumonia (OP) is composed of loose granulation tissue plugs in distal airspaces; these disappear with steroid treatment. Recently a variant labelled 'cicatricial' OP has been described in which the granulation tissue organised to much denser fibrous tissue but still retained the usual pattern of OP. Here we report 10 patients thought to have an interstitial lung disease, and who on biopsy had a variant of cicatricial OP characterised by linear bands or small nodular masses of dense fibrous tissue that does not resemble ordinary OP. Read More

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http://doi.wiley.com/10.1111/his.13443
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http://dx.doi.org/10.1111/his.13443DOI Listing
April 2018
8 Reads

Pathology-radiology correlation of common and uncommon computed tomographic patterns of organizing pneumonia.

Hum Pathol 2018 01 7;71:30-40. Epub 2017 Nov 7.

Department of Radiology, University of Texas Southwestern Medical Center, Dallas, TX, 75235.

Organizing pneumonia (OP) is a common pattern of lung injury that can be associated with a wide range of etiologies. Typical and not-so-typical imaging features of OP occur, as both common and rare lung pathologies can mimic the same imaging pattern as that of OP. This article will attempt to describe the difference between confusing terminologies that have been used in the past for OP and existence of primary versus secondary OP. Read More

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http://dx.doi.org/10.1016/j.humpath.2017.10.028DOI Listing
January 2018
6 Reads

High-resolution computed tomography findings in chronic eosinophilic vs. cryptogenic organising pneumonia.

Int J Tuberc Lung Dis 2017 11;21(11):1181-1186

Tracheal Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Background: The similar clinical and computed tomography (CT) characteristics of cryptogenic organising pneumonia (COP) and chronic eosinophilic pneumonia (CEP) make precise diagnosis challenging.

Objectives: To help differentiate between COP and CEP using high-resolution CT (HRCT).

Design: Clinical data and HRCT images of COP and CEP patients referred to Masih Daneshvari Hospital, Tehran, Iran, from 2007 to 2015 were reviewed. Read More

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http://dx.doi.org/10.5588/ijtld.16.0723DOI Listing
November 2017
2 Reads

Successful treatment of suspected organizing pneumonia in a patient without typical imaging and pathological characteristic: A case report.

Respir Med Case Rep 2017 18;22:246-250. Epub 2017 Sep 18.

Department of Pulmonary Diseases, Weihai Municipal Hospital, Weihai, Shandong, PR China.

Introduction: Organizing pneumonia (OP) is a clinicopathological entity characterized by granulation tissue plugs in the lumen of small airways, alveolar ducts, and alveoli. Diagnosis of OP needs the combination of clinical features, imaging and pathology. But it occurs often that there are no typical pathological features to support the diagnosis, which poses a challenge for clinicians' diagnosis and treatment. Read More

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http://dx.doi.org/10.1016/j.rmcr.2017.09.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5608601PMC
September 2017
12 Reads

Serial chest CT in cryptogenic organizing pneumonia: Evolutional changes and prognostic determinants.

Respirology 2018 03 27;23(3):325-330. Epub 2017 Sep 27.

Department of Radiology and Center for Imaging Science, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.

Background And Objective: Cryptogenic organizing pneumonia (COP) is corticosteroid responsive but residual computed tomography (CT) chest changes are often noted. The present study examined clinical and HRCT features of COP in which there was incomplete resolution.

Methods: We studied 93 patients with histopathologically confirmed COP and serial HRCT imaging. Read More

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http://dx.doi.org/10.1111/resp.13188DOI Listing
March 2018
4 Reads

Late-occurring nivolumab-induced cryptogenic organising pneumonia mimicking lung progression in a patient with metastatic non-small cell lung cancer.

Eur J Cancer 2017 11 13;85:155-157. Epub 2017 Sep 13.

Drug Development Department (DITEP), Gustave Roussy, and University Paris-Sud, Villejuif, France; INSERM U981, Gustave Roussy, University Paris XI, Villejuif, France.

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http://dx.doi.org/10.1016/j.ejca.2017.07.049DOI Listing
November 2017
31 Reads

Acute fibrinous and organising pneumonia.

BMJ Case Rep 2017 Sep 7;2017. Epub 2017 Sep 7.

Serviço de Medicina Interna B, Centro Hospitalar e Universitário de Coimbra, Coimbra, Portugal.

Acute fibrinous and organising pneumonia (AFOP) is a rare histological pattern of interstitial lung disease. The authors describe a 60-year-old woman admitted to the hospital for sustained fever, presenting with an alveolar opacity on chest X-ray, with the presumed diagnosis of community-acquired pneumonia and the onset of antibiotics. Since serological results suggested that was the infectious agent, she was discharged on levofloxacin. Read More

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http://dx.doi.org/10.1136/bcr-2016-218802DOI Listing
September 2017
11 Reads

Serological and morphological prognostic factors in patients with interstitial pneumonia with autoimmune features.

BMC Pulm Med 2017 Aug 14;17(1):111. Epub 2017 Aug 14.

Department of Respiratory Medicine, Kurashiki Central Hospital, Kurashiki, Japan.

Background: To identify the prognostic factors for survival in patients with interstitial pneumonia with autoimmune features (IPAF) who meet the serological domain of the IPAF criteria.

Methods: We retrospectively analysed 99 IPAF patients who met the serological domain and were hospitalised at the Respiratory Medicine Unit of Kurashiki Central Hospital from 1999 to 2015. The high-resolution computed tomography findings were usual interstitial pneumonia (UIP; n = 1), non-specific interstitial pneumonia (NSIP; n = 63), NSIP with organizing pneumonia (OP) overlap (n = 15), and OP (n = 20). Read More

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http://dx.doi.org/10.1186/s12890-017-0453-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5554971PMC
August 2017
24 Reads

Organizing Pneumonia in an Adult With Chronic Recurrent Noninfectious Osteomyelitis: A Case Report and Literature Review.

Chest 2017 08;152(2):e21-e24

Department of Medicine, University of British Columbia, Vancouver, Canada; Centre for Heart Lung Innovation, University of British Columbia, Vancouver, Canada.

Chronic recurrent multifocal osteomyelitis (CRMO) is an idiopathic inflammatory disorder primarily of children and adolescents that is characterized by multifocal nonpyogenic relapsing and remitting inflammatory bone lesions. Pulmonary abnormalities are rarely associated with CRMO, with two reported cases of consolidation on chest CT that occurred in children. We present a case of organizing pneumonia in an adult patient with CRMO. Read More

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http://dx.doi.org/10.1016/j.chest.2017.04.172DOI Listing
August 2017
9 Reads

[Cryptogenic organising pneumonia as a cause of chronic cough].

Semergen 2018 Mar 16;44(2):148-150. Epub 2017 Jun 16.

Centro de Salud Manzanares, Manzanares el Real, Madrid, España.

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https://linkinghub.elsevier.com/retrieve/pii/S11383593173014
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http://dx.doi.org/10.1016/j.semerg.2017.05.003DOI Listing
March 2018
1 Read

Retrospective evaluation of patients with organizing pneumonia: is cryptogenic organizing pneumonia different from secondary organizing pneumonia?

Tuberk Toraks 2017 Mar;65(1):1-8

Clinic of Chest Diseases, Ankara Ataturk Chest Diseases and Chest Surgery Training and Research Hospital, Ankara, Turkey.

Introduction: Organizing pneumonia (OP) is an uncommon clinic opathological situation among lung diseases. If no underlying cause can be detected, it is named as cryptogenic OP (COP). In this study, the etiologic and clinical characteristics of patients diagnosed as OP in our hospital in the last ten years were evaluated retrospectively. Read More

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March 2017
34 Reads

Detection of high serum levels of β-D-Glucan in disseminated nocardial infection: a case report.

BMC Infect Dis 2017 Apr 13;17(1):272. Epub 2017 Apr 13.

Second Department of Internal Medicine, Nagasaki University Hospital, 1-7-1 Sakamoto-machi, Nagasaki, Japan.

Background: β-D-glucan (BDG) is a helpful diagnostic marker for many invasive fungal infections, but not for nocardiosis. Here, we reported the first case of nocardial infection with high serum level of BDG.

Case Presentation: A 73-year-old man was hospitalized because of fever, headache, and appetite loss after 10 months of steroid and immunosuppressive therapy for cryptogenic organizing pneumonia. Read More

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http://dx.doi.org/10.1186/s12879-017-2370-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5390473PMC
April 2017
3 Reads
1 Citation
2.613 Impact Factor

"White-Out" After Lung Transplantation: A Multicenter Cohort Description of Late Acute Graft Failure.

Am J Transplant 2017 Jul 11;17(7):1905-1911. Epub 2017 Apr 11.

Department of Respiratory Medicine, Hannover Medical School, Hannover, Germany.

Graft failure represents a leading cause of mortality after organ transplantation. Acute late-onset graft failure has not been widely reported. The authors describe the demographics, CT imaging-pathology findings, and treatment of patients presenting with the latter. Read More

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http://dx.doi.org/10.1111/ajt.14268DOI Listing

Chest CT Signs in Pulmonary Disease: A Pictorial Review.

Chest 2017 06 16;151(6):1356-1374. Epub 2017 Feb 16.

Respiratory Institute, Cleveland Clinic, Cleveland, OH. Electronic address:

CT scanning of the chest is one of the most important imaging modalities available to a pulmonologist. The advent of high-resolution CT scanning of the chest has led to its increasing use. Although chest radiographs are still useful as an initial test, their utility is limited in the diagnosis of lung diseases that depend on higher resolution images such as interstitial lung diseases and pulmonary vascular diseases. Read More

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http://dx.doi.org/10.1016/j.chest.2016.12.033DOI Listing
June 2017
7 Reads

[Pulmonary intravascular large B-cell lymphomamanifesting as interstitial pneumonias: report of 2 cases and review of literature].

Zhonghua Jie He He Hu Xi Za Zhi 2017 Feb;40(2):108-113

Department of Respiratory Medicine, the Affiliated Drum Tower Hospital of Nanjing University, Nanjing 210008, China.

To investigate the clinical, radiographic characteristics and prognosis of pulmonary intravascular large B-cell lymphoma(IVLBCL) manifesting as interstitial pneumonias on HRCT. A retrospective analysis was carried out on clinical data of 2 patients with pulmonary IVLBCL admitted to the Affiliated Drum Tower Hospital of Nanjing University from March 2010 to May 2012. A literature research was performed with "pulmonary intravascular lymphoma" as the key word in Wanfang Database, China Knowledge Resource Integrated Database and Pubmed. Read More

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http://dx.doi.org/10.3760/cma.j.issn.1001-0939.2017.02.006DOI Listing
February 2017
11 Reads

Radio-pathological correlation of organizing pneumonia (OP): a pictorial review.

Br J Radiol 2017 Mar 17;90(1071):20160723. Epub 2017 Feb 17.

4 Department of Pathology, Chronic Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Since the description of cryptogenic organizing pneumonia in 1983 by Davison et al and the subsequent report on bronchiolitis obliterans organizing pneumonia by Epler et al, some reports have been published regarding the imaging features of organizing pneumonia (OP). In this pictorial review, we aimed to describe and illustrate different manifestations of OP on high-resolution CT (HRCT) accompanied by their histopathological correlations for a better comprehension of pathomechanism of the radiological findings. The main HRCT findings in OP include: consolidation, ground-glass opacification, perilobular opacity, reversed halo opacity, nodule or mass, parenchymal bands, bronchial wall thickening, bronchial dilatation, mediastinal lymphadenopathy and pleural effusion. Read More

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http://dx.doi.org/10.1259/bjr.20160723DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5601538PMC
March 2017
3 Reads
1.533 Impact Factor

High-resolution computed tomography to differentiate chronic diffuse infiltrative lung diseases with chronic multifocal consolidation patterns using logical analysis of data.

Sarcoidosis Vasc Diffuse Lung Dis 2016 Dec 23;33(4):355-371. Epub 2016 Dec 23.

Department of Radiology, Hôpital Saint-Louis, Assistance Publique-Hôpitaux de Paris, Université Paris 7 Denis Diderot, Sorbonne Paris-Cité, Paris, France.

Background: Chronic lung consolidation has a limited number of differential diagnoses requiring distinct managements. The aim of the study was to investigate how logical analysis of data (LAD) can support their diagnosis at HRCT (high-resolution computed tomography).

Methods: One hundred twenty-four patients were retrospectively included and classified into 8 diagnosis categories: sarcoidosis (n=35), connective tissue disease (n=21), adenocarcinoma (n=17), lymphoma (n=13), cryptogenic organizing pneumonia (n=11), drug-induced lung disease (n=9), chronic eosinophilic pneumonia (n =7) and miscellaneous (n=11). Read More

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December 2016
13 Reads

Clarithromycin Decreases IL-6 Concentration in Serum and BAL Fluid in Patients with Cryptogenic Organizing Pneumonia.

Adv Clin Exp Med 2016 Sep-Oct;25(5):871-878

Third Department of Lung Disease, National Tuberculosis and Lung Disease Research Institute, Warszawa, Poland.

Background: Inflammatory cytokines are involved in the development of cryptogenic organizing pneumonia (COP). It has been shown that macrolides inhibit cytokine production in the alveolar macrophages of COP patients.

Objectives: The aim of the study was to assess the concentrations of interleukin 1β (IL-1β), IL-6, IL-8 and transforming growth factor β (TGF-β) in serum and in bronchoalveolar lavage fluid (BAL-f) in COP patients treated with clarithromycin (CAM). Read More

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http://dx.doi.org/10.17219/acem/61953DOI Listing
June 2017
6 Reads

Possible relationship between organizing pneumonia and chronic pulmonary aspergillosis: A case report and literature review.

Respir Investig 2017 Jan 31;55(1):74-78. Epub 2016 Aug 31.

Department of Respiratory Medicine, National Center for Global Health and Medicine Kohnodai Hospital, 1-7-1 Kohnodai ichikawa-shi, Chiba 272-8516, Japan. Electronic address:

Organizing pneumonia (OP) is a nonspecific response to various forms of lung injury and has been reported in association with several infectious agents. However, little is known about the relationship between OP and chronic pulmonary aspergillosis, and the mechanism of this linkage has not been elucidated. Here, we present a case of chronic pulmonary aspergillosis that led to the development of OP, which was successfully treated with corticosteroid and surgical intervention. Read More

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http://dx.doi.org/10.1016/j.resinv.2016.07.004DOI Listing
January 2017
6 Reads

Giant bulla formation in the lung because of a check-valve mechanism.

Respir Investig 2017 Jan 11;55(1):63-68. Epub 2016 Nov 11.

Department of Respiratory Medicine, Kyorin University School of Medicine, 6-20-2 Shinkawa, Mitaka City, Tokyo 181-8611, Japan. Electronic address:

The pathogenesis of bulla formation has not yet been demonstrated in pathologic examinations or through direct visualization during thoracotomy or thoracoscopic surgery. We present two cases of giant bulla formation after pneumothorax because of cryptogenic organizing pneumonia and lung abscess. The case findings suggested that the pathogenesis was attributable to a check-valve mechanism, secondary to bronchiolitis obliterans, or the presence of an obstructing air leakage due to a lung fistula. Read More

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http://dx.doi.org/10.1016/j.resinv.2016.10.006DOI Listing
January 2017
8 Reads

[Clinical manifestations of organizing pneumonia].

Medicina (B Aires) 2016;76(6):338-342

Servicio de Clínica Médica, Instituto de Investigaciones Médicas Alfredo Lanari, Universidad de Buenos Aires, Argentina.

Organizing pneumonia is a clinical entity asociated with nonspecific symptoms and radiological findings and abnormalities in pulmonary function tests. It is defined by the characteristic histopathological pattern: filling of alveoli and respiratory bronchioles by plugs of granulation tissue. It can be idiopathic (COP) or secondary to other causes (SOP). Read More

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August 2017
4 Reads

Patterns of interstitial lung disease and mortality in rheumatoid arthritis.

Rheumatology (Oxford) 2017 03;56(3):344-350

Division of Rheumatology.

Objective: To characterize a cohort of patients with RA who have interstitial lung disease (ILD) and to assess the utility of previously developed mortality staging systems [gender, age, lung physiology (GAP) and ILD-GAP].

Methods: All patients with RA and ILD seen at the Mayo Clinic from 1998 to 2014 were identified and manually screened for study inclusion. RA disease characteristics and pulmonary findings including high-resolution CT and pulmonary function testing were evaluated. Read More

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http://dx.doi.org/10.1093/rheumatology/kew391DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6251572PMC
March 2017
28 Reads

Acute Fibrinous and Organizing Pneumonia with Myelodysplastic Syndrome: Corticosteroid Monotherapy Led to Successful Ventilator Weaning.

Intern Med 2016;55(21):3155-3159. Epub 2016 Nov 1.

Tokyo Metropolitan Tama Medical Center, Japan.

A 62-year-old man with myelodysplastic syndrome (MDS) presented to our hospital with a high fever. Although treatment with broad-spectrum antibiotics was initiated, his respiratory status worsened to the point that he required mechanical ventilation. However, he was successfully treated with a corticosteroid without immunosuppression. Read More

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http://dx.doi.org/10.2169/internalmedicine.55.6864DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5140866PMC
January 2017
7 Reads

[Reversed halo sign: chest CT findings in 5 patients and cause analysis].

Zhonghua Jie He He Hu Xi Za Zhi 2016 Oct;39(10):757-762

Department of Respiratory Medicine, Peking University Third Hospital, Beijing 100191, China.

To describe diseases that may present with the reversed halo sign (RHS) on high-resolution CT, and therefore to improve the recognition of this thoracic radiological feature. We retrospectively reviewed the HRCT scans and medical records of 5 patients who presented with RHS on chest CT from Peking University Third Hospital. With "reversed halo sign, fairy ring, atoll sign" as the Chinese and English keywords, 420 cases from the literatures were also reviewed through PubMed, Wanfang and CNKI databases until August 2015. Read More

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http://dx.doi.org/10.3760/cma.j.issn.1001-0939.2016.10.003DOI Listing
October 2016
7 Reads

Organizing pneumonia and pulmonary tuberculosis: Coexistent or associated diseases.

Arch Bronconeumol 2016 Nov 4;52(11):570-571. Epub 2016 May 4.

Servicio de Neumología, Hospital San Jorge, Huesca, España.

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http://dx.doi.org/10.1016/j.arbres.2016.03.009DOI Listing
November 2016
3 Reads

Synchronous Pneumatocele and Organizing Pneumonia in the Course of a Staphylococcus aureus Infection.

Arch Bronconeumol 2016 Nov 17;52(11):561. Epub 2016 Feb 17.

Servicio de Neumología, Hospital Sousa Martins, ULS Guarda, Guarda, Portugal; Facultad de Ciencias de la Salud, Universidad de Beira Interior, Covilhã, Portugal.

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http://dx.doi.org/10.1016/j.arbres.2015.12.005DOI Listing
November 2016
1 Read

Computed Tomographic Appearance of Organizing Pneumonia in an Oncologic Patient Population.

J Comput Assist Tomogr 2017 May/Jun;41(3):437-441

From the Departments of *Radiology, †Medicine, and ‡Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY.

Objective: The aims of this study were to describe the computed tomographic features of organizing pneumonia (OP) in an oncologic patient population and to also identify features associated with lung cancer and patients undergoing hematopoietic stem cell transplant (HSCT).

Methods: In retrospective computed tomographies from 151 patients with pathologically confirmed OP between January 2009 and September 2014, number of lesions, location, size, margin type, and consistency, as well as volume of lymphadenopathy and the presence and size of pleural effusions, were recorded. Associated malignancy was noted. Read More

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http://dx.doi.org/10.1097/RCT.0000000000000520DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5469368PMC
July 2017
38 Reads

Utility of Transbronchial vs Surgical Lung Biopsy in the Diagnosis of Suspected Fibrotic Interstitial Lung Disease.

Chest 2017 02 8;151(2):389-399. Epub 2016 Oct 8.

Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Michigan Health System, Ann Arbor, MI.

Background: Surgical lung biopsy (SLB) is invasive and not possible in all patients with undiagnosed interstitial lung disease (ILD). We hypothesized that transbronchial biopsy (TBB) findings combined with clinical and high-resolution CT (HRCT) data leads to a confident diagnosis congruent to SLB and therefore avoids the need for SLB in some patients.

Methods: We evaluated 33 patients being investigated for suspected ILD who underwent HRCT, TBB, and SLB. Read More

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http://dx.doi.org/10.1016/j.chest.2016.09.028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5310128PMC
February 2017
23 Reads

A case report of acute fibrinous and organizing pneumonia with pneumothorax and avian exposure history.

Clin Respir J 2018 Feb 23;12(2):811-815. Epub 2016 Sep 23.

Department of Pathology, First Affiliated Hospital of Guangzhou Medical Collage, Guangzhou, Guangdong, CN.

Acute fibrinous and organizing pneumonia (AFOP) is an uncommon variant of acute lung injury. Here, we report a patient with AFOP and a previously unreported condition, pneumothorax. After our experience with this case, we suggest that exposure to birds may be associated with AFOP; pneumothorax can develop in patients with AFOP; and glucocorticoids are very effective for treating AFOP. Read More

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http://dx.doi.org/10.1111/crj.12553DOI Listing
February 2018
9 Reads

Successful Treatment of Fibrosing Organising Pneumonia Causing Respiratory Failure with Mycophenolic Acid.

Respiration 2016 9;92(4):279-282. Epub 2016 Sep 9.

Division of Respirology, Western University, London, Ont., Canada.

Organising pneumonia (OP) is usually promptly responsive to corticosteroid treatment. We describe a series of 3 cases of severe, progressive, biopsy-proven fibrosing OP causing respiratory failure. All cases presented with peribronchial and subpleural consolidations, had a fibro-inflammatory infiltrative component in the alveolar septa, and only had a partial and unsatisfactory response to corticosteroids. Read More

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http://dx.doi.org/10.1159/000448846DOI Listing
September 2017
4 Reads

Subacute pneumonia as a manifestation of acute fibrinous and organizing pneumonia.

Arch Bronconeumol 2017 Mar 1;53(3):167-168. Epub 2016 Aug 1.

Servicio de Neumología, Instituto de Investigación Biomédica de A Coruña (INIBIC), Complejo Hospitalario Universitario de A Coruña (CHUAC), Sergas, Universidade de A Coruña (UDC), A Coruña, España. Electronic address:

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http://dx.doi.org/10.1016/j.arbres.2016.07.001DOI Listing
March 2017
3 Reads

Haemoptysis as a primary manifestation of cryptogenic organizing pneumonia (COP).

Pneumologia 2015 Oct-Dec;64(4):37-40

Cryptogenic organizing pneumonia (COP), previously called bronchiolitis obliterans organizing pneumonia (BOOP) is a clinicopathological disorder of unknown aetiology but increasingly reported. It usually presents with symptoms of dyspnea, cough, fever, weight loss accompanied by the presence of alveolar opacities on chest radiograph. Haemoptysis, described as blood streaking has only rarely been reported as primary presentation of COP. Read More

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August 2016
4 Reads

[Bronchitis obliterans associated with bronchiolitis obliterans with organizing pneumonia in a child and literature review].

Zhonghua Er Ke Za Zhi 2016 Jul;54(7):523-6

Department of Respiratory Diseases, Nanjing Children's Hospital Affiliated to Nanjing Medical University, Nanjing 210008, China.

Objective: To investigate the clinical-radiologic-pathologic features of bronchitis obliterans that complicated with bronchiolitis obliterans with organizing pneumonia (BOOP).

Method: The clinical manifestations, characteristic imaging and pathology of a case with pediatric Mycoplasma pneumoniae pneumonia (MPP) complicated with bronchitis obliterans and BOOP were summarized and relative articles were reviewed.

Result: A 10-year-old girl complained of recurrent paroxysmal cough and episodes of wheezing with exercise, productive of yellowish sputum, irregular fever for 1 month presented with lower breath sounds of left lower lobe and localized tubular breath sounds. Read More

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http://doi.med.wanfangdata.com.cn/10.3760/cma.j.issn.0578-13
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http://dx.doi.org/10.3760/cma.j.issn.0578-1310.2016.07.010DOI Listing
July 2016
3 Reads

Ochronosis of the knee with secondary osteoarthritis requiring total knee replacement in a patient with cryptogenic organising pneumonia.

BMJ Case Rep 2016 May 20;2016. Epub 2016 May 20.

Department of Orthopedics, Alrijne Ziekenhuis, Leiderdorp, The Netherlands.

Ochronosis is a rare autosomal recessive metabolic disease caused by homogentisic acid oxidase enzyme deficiency. High homogentisic acid levels will eventually result in black deposits in skin, sclerae, connective tissues and urine (alkaptonuria). It can lead to early degeneration of connective tissues and cartilage. Read More

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http://dx.doi.org/10.1136/bcr-2016-215412DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4885480PMC
May 2016
6 Reads

'Crazy-paving' pattern: an exceptional presentation of cryptogenic organising pneumonia associated with chronic obstructive pulmonary disease.

BMJ Case Rep 2016 May 6;2016. Epub 2016 May 6.

Department of Pulmonary Medicine, Vallabhbhai Patel Chest Institute, University of Delhi, Delhi, India.

Organising pneumonia (OP) is a distinct but uncommon entity with characteristic clinicoradiological features and histological findings. When the aetiology of OP remains unknown, it is termed as cryptogenic OP (COP). COP is seen in the majority of patients with OP and usually observed in non/former smokers. Read More

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http://dx.doi.org/10.1136/bcr-2016-215445DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4885474PMC
May 2016
6 Reads

Resolution of organizing pneumonia following immunosuppressive therapy for large granular lymphocytic leukemia.

Ann Hematol 2016 Aug 2;95(8):1357-9. Epub 2016 May 2.

Faculdade de Medicina de Campos, Hospital Escola Álvaro Alvim, Campos dos Goytacazes, Rio de Janeiro, Brazil.

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http://link.springer.com/10.1007/s00277-016-2687-x
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http://dx.doi.org/10.1007/s00277-016-2687-xDOI Listing
August 2016
5 Reads

Chest CT for suspected pulmonary complications of oncologic therapies: how I review and report.

Authors:
Stefan Diederich

Cancer Imaging 2016 Apr 11;16. Epub 2016 Apr 11.

Department of Diagnostic and Interventional Radiology, Marien Hospital, Academic Teaching Hospital, Rochusstr. 2, D- 40479, Düsseldorf, Germany.

In cancer patient during or following oncologic therapies with respiratory symptoms and pulmonary pathology at chest CT the differential diagnosis includes infection, therapy-induced disease and tumour progression.Although CT morphology may be typical or even pathognomonic in some conditions the diagnosis is usually made by a synopsis of imaging, clinical and laboratory features.Close communication with referring colleagues and a good knowledge of potential side effects of therapeutic concepts, their time course and CT morphology is crucial in the differential diagnosis. Read More

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http://dx.doi.org/10.1186/s40644-016-0066-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4828781PMC
April 2016
8 Reads

Acute fibrinous and organising pneumonia: a rare histopathological variant of chemotherapy-induced lung injury.

BMJ Case Rep 2016 Apr 6;2016. Epub 2016 Apr 6.

University of Texas Southwestern Medical Center, Dallas, Texas, USA.

Bleomycin-induced lung injury is the most common chemotherapy-associated lung disease, and is linked with several histopathological patterns. Acute fibrinous and organising pneumonia (AFOP) is a relatively new and rare histological pattern of diffuse lung injury. We report the first known case of bleomycin-induced AFOP. Read More

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http://casereports.bmj.com/content/2016/bcr-2016-214721.full
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http://dx.doi.org/10.1136/bcr-2016-214721DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4840647PMC
April 2016
3 Reads

Spontaneous resolution of cryptogenic organizing pneumonia in pediatrics: A case report.

Arch Pediatr 2016 May 24;23(5):519-22. Epub 2016 Mar 24.

Department of radiology Hôtel-Dieu de France hospital, boulevard Alfred Naccach, Achrafieh, PO Box 166830, Beirut, Lebanon.

Cryptogenic organizing pneumonia (COP) is a rare entity in childhood, particularly in previously healthy children. Moreover, the spontaneous remission of the disease is exceptional. We report on the case of a previously healthy 10-year-old girl who consulted her doctor for a 2-month history of mild pyrexia, fatigue, weight loss, and exertional dyspnea with no response to amoxicillin. Read More

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http://dx.doi.org/10.1016/j.arcped.2016.02.021DOI Listing
May 2016
1 Read