637 results match your criteria Imaging in Bronchiolitis Obliterans Organizing Pneumonia

Integrated approach to bronchoalveolar lavage cytology to distinguish interstitial lung diseases.

Eur J Intern Med 2021 Apr 27. Epub 2021 Apr 27.

Department of Medical Sciences, Surgery and Neurosciences, Respiratory Disease and Lung Transplant Unit, Siena University, Siena, Italy.

Background: Broncho-alveolar lavage (BAL) is a safe diagnostic procedure, useful for differentiating fibrotic lung disorders and for excluding malignancy and infection. A recent multicenter study demonstrated a new, relatively sensitive, and specific index called Bronchoalveolar Cytology Threshold (BCT), useful for distinguishing healthy individuals from patients with lung diseases.

Objectives: In our study, BCT was applied for the first time to the analysis of interstitial lung diseases (ILDs), investigating its potential for differential diagnosis. Read More

View Article and Full-Text PDF

Interstitial lung abnormality (ILA) and nonspecific interstitial pneumonia (NSIP).

Eur J Radiol Open 2021 16;8:100336. Epub 2021 Mar 16.

Center for Pulmonary Functional Imaging, Department of Radiology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.

This review article aims to address mysteries existing between Interstitial Lung Abnormality (ILA) and Nonspecific Interstitial Pneumonia (NSIP). The concept and definition of ILA are based upon CT scans from multiple large-scale cohort studies, whereas the concept and definition of NSIP originally derived from pathology with evolution to multi-disciplinary diagnosis. NSIP is the diagnosis as Interstitial Lung Disease (ILD) with clinical significance, whereas only a part of subjects with ILA have clinically significant ILD. Read More

View Article and Full-Text PDF

Interstitial Lung Disease in Common Variable Immunodeficiency.

Front Immunol 2021 11;12:605945. Epub 2021 Mar 11.

Division of Clinical Immunology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, United States.

Interstitial lung disease (ILD) is a common complication in patients with common variable immunodeficiency (CVID) and often associated with other features, such as bronchiectasis and autoimmunity. As the ILD term encompasses different acute and chronic pulmonary conditions, the diagnosis is commonly made based on imaging features; histopathology is less frequently available. From a cohort of 637 patients with CVID followed at our center over 4 decades, we reviewed the data for 46 subjects (30 females, 16 males) who had lung biopsies with proven ILD. Read More

View Article and Full-Text PDF

A rare cause of secondary organising pneumonia.

BMJ Case Rep 2021 Mar 5;14(3). Epub 2021 Mar 5.

Pulmonology Department, Hospital Pedro Hispano, Matosinhos, Portugal.

Non-tuberculous mycobacterial pulmonary disease may have different clinical manifestations. We report a case of a 64-year-old woman presenting with persistent respiratory complaints, fever and radiological findings. Initially, she was diagnosed with community-acquired pneumonia, but after being submitted to an extensive investigation, including CT-guided transthoracic lung biopsy, a diagnosis of organising pneumonia (OP) was established. Read More

View Article and Full-Text PDF

Organizing pneumonia and COVID-19: A report of two cases.

Respir Med Case Rep 2021 31;32:101359. Epub 2021 Jan 31.

Department of Internal Medicine II at Santa Maria Hospital, Centro Hospitalar Universitário Lisboa Norte, EPE, Portugal.

Organizing pneumonia (OP) is a sub-acute process of pulmonary tissue repair secondary to lung injury, defined histopathologically by intra-alveolar buds of granulation tissue within the lumen of distal pulmonary airspaces. It can be either cryptogenic or secondary (SOP) to different clinical conditions, namely infections. Despite being nonspecific, its diagnosis can be made by the association of clinical and imaging criteria. Read More

View Article and Full-Text PDF
January 2021

Organizing pneumonia as a manifestation of coronavirus disease 2019.

Pathol Int 2021 03 27;71(3):210-212. Epub 2021 Jan 27.

Department of Pathology, University of Michigan, Ann Arbor, MI, USA.

View Article and Full-Text PDF

Disease-modifying antirheumatic drugs and organising pneumonia.

BMJ Case Rep 2021 Jan 6;14(1). Epub 2021 Jan 6.

Respiratory Unit, Department of Medicine, Faculty of Medicine, Universiti Kebangsaan Malaysia Medical Centre, Cheras, Kuala Lumpur, Malaysia

Organising pneumonia (OP) in rheumatoid arthritis (RA) may be part of pulmonary manifestation (disease related) or disease-modifying antirheumatic drugs (DMARDs) related. We report a case series of RA patients with DMARDs related OP. A 65-year-old woman developed OP 3 weeks after initiation of methotrexate (MTX). Read More

View Article and Full-Text PDF
January 2021

A 65-year-old Woman With Persistent Dyspnea, Arthritis, and Raynaud's Phenomenon.

Am J Med Sci 2021 04 22;361(4):526-533. Epub 2020 Nov 22.

Department of Pulmonary and Critical Care Medicine, Albany Medical Center, New York.

Antisynthetase syndrome (AS) is a rare disease that affects patients with inflammatory myopathies such as polymyositis (PM) and dermatomyositis (DM). In patients with AS, up to 95% of patients develop antisynthetase syndrome-associated interstitial lung disease (AS-ILD). Although AS-ILD commonly occurs in patients with a well-established diagnosis of AS, it can be the first or only manifestation of an occult AS. Read More

View Article and Full-Text PDF

COVID-19 mimics on chest CT: a pictorial review and radiologic guide.

Br J Radiol 2021 Feb 9;94(1118):20200703. Epub 2020 Dec 9.

Department of Radiology, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.

Chest imaging is often used as a complementary tool in the evaluation of coronavirus disease 2019 (COVID-19) patients, helping physicians to augment their clinical suspicion. Despite not being diagnostic for COVID-19, chest CT may help clinicians to isolate high suspicion patients with suggestive imaging findings. However, COVID-19 findings on CT are also common to other pulmonary infections and non-infectious diseases, and radiologists and point-of-care physicians should be aware of possible mimickers. Read More

View Article and Full-Text PDF
February 2021

A Duck after Treatment for Extensive Organizing Pneumonia.

Intern Med 2021 May 7;60(9):1477-1478. Epub 2020 Dec 7.

Respiratory Medicine and Infectious Diseases, Oita University Faculty of Medicine, Japan.

View Article and Full-Text PDF

Content-Based Image Retrieval of Chest CT with Convolutional Neural Network for Diffuse Interstitial Lung Disease: Performance Assessment in Three Major Idiopathic Interstitial Pneumonias.

Korean J Radiol 2021 02 21;22(2):281-290. Epub 2020 Oct 21.

Department of Radiology and Research Institute of Radiology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.

Objective: To assess the performance of content-based image retrieval (CBIR) of chest CT for diffuse interstitial lung disease (DILD).

Materials And Methods: The database was comprised by 246 pairs of chest CTs (initial and follow-up CTs within two years) from 246 patients with usual interstitial pneumonia (UIP, n = 100), nonspecific interstitial pneumonia (NSIP, n = 101), and cryptogenic organic pneumonia (COP, n = 45). Sixty cases (30-UIP, 20-NSIP, and 10-COP) were selected as the queries. Read More

View Article and Full-Text PDF
February 2021

Bronchiolitis obliterans organizing pneumonia as the pulmonary manifestation of lupus: A review of three cases.

Lupus 2021 Feb 26;30(2):336-341. Epub 2020 Oct 26.

Department of Clinical Immunology and Rheumatology, Nizam's Institute of Medical Sciences (NIMS), Hyderabad, India.

Objective: Bronchiolitis obliterans organizing pneumonia (BOOP) is a clinico-patho-radiological diagnosis which rarely presents as a pulmonary manifestation of lupus. In this concise report, organizing pneumonia was found as the sole pulmonary manifestation of SLE in different age groups.

Method: All three patients diagnosed with SLE according to SLICC 2012 classification criteria, were admitted in rheumatology ward of NIMS hospital, Hyderabad, India from May to November, 2018. Read More

View Article and Full-Text PDF
February 2021

Radiographic features and poor prognostic factors of interstitial lung disease with nivolumab for non-small cell lung cancer.

Cancer Sci 2021 Apr 24;112(4):1495-1505. Epub 2021 Feb 24.

The Jikei University School of Medicine, Tokyo, Japan.

Nivolumab can cause interstitial lung disease (ILD), which may be fatal; however, mortality risk factors have not been identified. This postmarketing study evaluated the poor prognostic factors of ILD in nivolumab-treated patients with non-small cell lung cancer (NSCLC) in Japan. Clinical and chest imaging findings for each ILD case were assessed by an expert central review committee, and prognosis was evaluated by radiographic findings, including the presence/absence of peritumoral ground-glass opacity (peritumoral-GGO). Read More

View Article and Full-Text PDF

Granulomatosis with polyangiitis complicated with refractory optic neuritis and maxillary osteomyelitis.

Mod Rheumatol Case Rep 2020 01 18;4(1):79-83. Epub 2019 Jul 18.

Research Center for Allergy and Clinical Immunology, Asahi General Hospital, Asahi, Chiba.

We report a case of a 61-year-old man with granulomatosis with polyangiitis (GPA) complicated with refractory optic neuritis and maxillary osteomyelitis. He had been treated with prednisolone (PSL) as cryptogenic organizing pneumonia in the respiratory department for 2 years. Afterward, he complained tenderness of paranasal sinuses and rapidly progressive visual loss of the left eye. Read More

View Article and Full-Text PDF
January 2020

Are there overlapping clinical features between thoracic radiotherapy side effects and covid-19 pneumonia? Radiation pneumonitis outside the radiation ports: Three case reports.

Clin Transl Radiat Oncol 2020 Nov 25;25:107-111. Epub 2020 Sep 25.

Radiation Oncology Unit, San Giuseppe Moscati Hospital, Strada per Martina Franca 74100, Taranto, Italy.

Respiratory involvement of COVID-19 infection, with presentations ranging from a mild flu-like illness to potentially lethal acute respiratory distress syndrome, is the main clinical manifestation in adults. Chest imaging shows a pictorial fashion of images due to the severity and stage of the disease, starting from focal nodular or mass-like opacities with air bronchogram to areas of ground glass consolidation or whited out lung. However, during the COVID-19 pandemic, CT findings could yield confounding reporting in the case of cancer patients previously treated with thoracic radiotherapy (tRT) due to atypical radiation pneumonitis occurring outside the radiation ports. Read More

View Article and Full-Text PDF
November 2020

SARS-CoV-2 organising pneumonia: 'Has there been a widespread failure to identify and treat this prevalent condition in COVID-19?'

BMJ Open Respir Res 2020 09;7(1)

School of Medicine and Public Health, University of Wisconsin-Madison, Madison, Wisconsin, USA.

Reviews of COVID-19 CT imaging along with postmortem lung biopsies and autopsies indicate that the majority of patients with COVID-19 pulmonary involvement have secondary organising pneumonia (OP) or its histological variant, acute fibrinous and organising pneumonia, both well-known complications of viral infections. Further, many publications on COVID-19 have debated the puzzling clinical characteristics of 'silent hypoxemia', 'happy hypoxemics' and 'atypical ARDS', all features consistent with OP. The recent announcement that RECOVERY, a randomised controlled trial comparing dexamethasone to placebo in COVID-19, was terminated early due to excess deaths in the control group further suggests patients present with OP given that corticosteroid therapy is the first-line treatment. Read More

View Article and Full-Text PDF
September 2020

Immune-related adverse events on body CT in patients with small-cell lung cancer treated with immune-checkpoint inhibitors.

Eur J Radiol 2020 Nov 10;132:109275. Epub 2020 Sep 10.

Department of Imaging, Dana-Farber Cancer Institute, 450 Brookline Ave, Boston, MA, 02215, USA; Department of Radiology, Brigham and Women's Hospital, 75 Francis Street, Boston, MA 02115, USA. Electronic address:

Purpose: Investigate the incidence and imaging characteristics of radiologically-evident immune-related adverse events (irAEs) on body CT in patients with small-cell lung cancer (SCLC) treated with immune-checkpoint inhibitors.

Methods: The study included 53 patients with relapsed/refractory SCLC (27 men, 26 women) treated with PD-1/PD-L1 inhibitors alone or in combination with CTLA-4 inhibition, who had baseline and at least one follow-up body CT during therapy. Body CT scans were reviewed to detect and characterize organ-specific irAEs including thyroiditis, pneumonitis, hepatitis, pancreatitis, enteritis, and colitis. Read More

View Article and Full-Text PDF
November 2020

E-cigarette-induced lung disease: from acute to chronic.

Lancet 2020 08;396(10250):564

Institute of Radiology, University Medical Center Regensburg, Regensburg, Germany.

View Article and Full-Text PDF

What lies beneath: poking a hole in the diagnosis.

Thorax 2020 11 20;75(11):1017-1019. Epub 2020 Aug 20.

Pulmonary, Critical Care and Sleep Medicine, Westchester Medical Center Health Network, Valhalla, New York, USA.

View Article and Full-Text PDF
November 2020

Clinical and radiological features of immune checkpoint inhibitor-related pneumonitis in lung cancer and non-lung cancers.

Br J Radiol 2020 Nov 12;93(1115):20200409. Epub 2020 Aug 12.

Department of Radiology, Tenri Hospital, Nara, Japan.

Objective: To investigate the clinical and radiological features of immune checkpoint inhibitor-related pneumonitis (ICI-P), a rare but serious pulmonary complication of cancer immunotherapy and to evaluate key differences between lung cancer (LC) and non-LC patients.

Methods: 247 patients (LC, = 151) treated with ICI for malignancies were retrospectively screened in a single institute. The number of patients, history of other immune-related adverse events (irAE), the onset, serum KL-6 levels, and chest CT features (types of pneumonitis, symmetry, laterality, location) were recorded for the ICI-P population and compared for LC and non-LC groups. Read More

View Article and Full-Text PDF
November 2020

[Analysis of clinical characteristics of 21 cases of acute fibrinous and organizing pneumonia].

Zhonghua Jie He He Hu Xi Za Zhi 2020 Aug;43(8):670-676

Department of Pulmonary and Critical Care Medcine, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China.

To summarize the clinical features of 21 cases of acute fibrinous and organizing pneumonia (AFOP) confirmed by pathology, thereby improving clinicians' understanding of this disease and avoiding misdiagnosis in clinical practice. Twenty-one patients diagnosed pathologically with AFOP from January 2016 to April 2019 were analyzed retrospectively. The clinical symptoms, laboratory examination results, imaging features, treatments and outcomes were analyzed comprehensively. Read More

View Article and Full-Text PDF

Secondary organizing pneumonia associated with sertraline: A case report.

Respir Med Case Rep 2020 2;31:101141. Epub 2020 Jul 2.

Division of Pneumology, CHU UCL Namur (Godinne Site), Université Catholique de Louvain (UCL), Avenue Gaston Therasse, 1 - 5530, Yvoir, Belgium.

Cryptogenic organizing pneumonia is a rare idiopathic interstitial lung disease, with a well-defined clinical-radiological and pathological entity. It may also be secondary to several causes. Rapid clinical and imaging improvement is usually obtained with corticosteroid therapy. Read More

View Article and Full-Text PDF

Analysis of the clinical characteristics of 176 patients with pathologically confirmed cryptogenic organizing pneumonia.

Ann Transl Med 2020 Jun;8(12):763

Department of Respiratory Medicine, Shanghai Pulmonary Hospital, Tongji University, School of Medicine, Shanghai, China.

Background: Cryptogenic organizing pneumonia (COP), is a form of idiopathic interstitial pneumonia (IIP) and is diagnosed by clinical-radiologic-pathologic (CRP) diagnosis. To summarize the clinical, imaging, pathological, and prognostic characteristics of 176 patients with confirmed COP.

Methods: Patients who were diagnosed with organizing pneumonia (OP) by lung biopsy between January 1, 2000, and December 31, 2013, in our hospital were retrospectively analyzed and followed up until 12/31/2017. Read More

View Article and Full-Text PDF

Diagnostic Accuracy of Multidetector CT in Detection of Early Interstitial Lung Disease With Its Role in Characterization.

Cureus 2020 May 23;12(5):e8253. Epub 2020 May 23.

Radiodiagnosis, Era's Lucknow Medical College and Hospital, Lucknow, IND.

Background Multidetector CT (MDCT) has emerged as a useful option for early diagnosis of interstitial lung disease (ILD) with adequate accuracy. Methods A total of 80 patients with restricted pulmonary functions and clinical suspicion of ILD were enrolled in the study. MDCT evaluation was done using Siemens Somatom Force 384 slice multidetector computer tomography machine. Read More

View Article and Full-Text PDF

Chemotherapy-induced pulmonary complications in cancer: Significance of clinicoradiological correlation.

Indian J Radiol Imaging 2020 Jan-Mar;30(1):20-26. Epub 2020 Mar 30.

Department of Radiodiagnosis, Dr B.R.A. Institute Rotary Cancer Hospital, All India Institute of Medical Sciences, New Delhi, India.

Chemotherapy while revolutionizing cancer management by improving survival and quality of life; is also associated with several adverse effects. Lung is the most common organ affected in chemotherapy-related complications, due to either drug toxicity or more commonly due to infections caused by immunosuppression and less commonly due to immune-mediated injury. Radiology, when used in combination with clinical and lab data, can help reach the specific diagnosis or narrow down the differentials. Read More

View Article and Full-Text PDF

Radiographic patterns of symptomatic radiation pneumonitis in lung cancer patients: Imaging predictors for clinical severity and outcome.

Lung Cancer 2020 07 30;145:132-139. Epub 2020 Apr 30.

Department of Imaging, Dana Farber Cancer Institute, 450 Brookline Ave, Boston, MA, 02215, USA; Department of Radiology, Brigham and Women's Hospital, 75 Francis Street, Boston, MA 02115, USA. Electronic address:

Objective: Investigate the spectrum of radiographic patterns of radiation pneumonitis (RP) in lung cancer patients and identify imaging markers for high-grade RP and RP-related death.

Methods: Eighty-two patients with lung cancer treated with conventional chest radiotherapy who had symptomatic RP were identified from the radiation oncology database. The imaging features of RP were studied for association with high-grade RP (Grade ≥3) and RP-related death (Grade 5). Read More

View Article and Full-Text PDF

Clinical and imaging characteristics of hematologic disease complicated by air leak syndrome: A STROBE-compliment observational study.

Medicine (Baltimore) 2020 May;99(20):e19948

Department of Radiology, State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College.

There are limited systematic studies on hematologic disease complicated by air leak syndrome (ALS). Physicians in radiology departments and hematology departments have a limited awareness of ALS.The aim of this study was to explore the similarities and differences in clinical data between the clinical group and imaging group in patients with hematologic disease complicated by ALS. Read More

View Article and Full-Text PDF

[Chest High-resolution Computed Tomography Imaging Features of Lung Involvement in Rheumatoid Arthritis].

Zhongguo Yi Xue Ke Xue Yuan Xue Bao 2020 Apr;42(2):202-208

Department of Radiology, PUMC Hospital,CAMS and PUMC,Beijing 100730,China.

To explore the chest high-resolution computed tomography (HRCT) features in patients with rheumatoid arthritis (RA) complicated with pulmonary involvement. Totally 161 patients with RA with lung involvement were collected from June 2014 to May 2018. The chest HRCT findings were retrospectively analyzed. Read More

View Article and Full-Text PDF

Machine Learning Algorithms to Differentiate Among Pulmonary Complications After Hematopoietic Cell Transplant.

Chest 2020 09 25;158(3):1090-1103. Epub 2020 Apr 25.

Department of Medicine, the Division of Pulmonary, Allergy, and Critical Care Medicine, Stanford University School of Medicine, Stanford, CA. Electronic address:

Background: Pulmonary complications, including infections, are highly prevalent in patients after hematopoietic cell transplantation with chronic graft-vs-host disease. These comorbid diseases can make the diagnosis of early lung graft-vs-host disease (bronchiolitis obliterans syndrome) challenging. A quantitative method to differentiate among these pulmonary diseases can address diagnostic challenges and facilitate earlier and more targeted therapy. Read More

View Article and Full-Text PDF
September 2020